HNRNPDL

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: This gene belongs to the subfamily of ubiquitously expressed heterogeneous nuclear ribonucleoproteins (hnRNPs). The hnRNPs are RNA binding proteins and they complex with heterogeneous nuclear RNA (hnRNA). These proteins are associated with pre-mRNAs in the nucleus and appear to influence pre-mRNA processing and other aspects of mRNA metabolism and transport. While all of the hnRNPs are present in the nucleus, some seem to shuttle between the nucleus and the cytoplasm. The hnRNP proteins have distinct nucleic acid binding properties. The protein encoded by this gene has two RRM domains that bind to RNAs. Three alternatively spliced transcript variants have been described for this gene. One of the variants is probably not translated because the transcript is a candidate for nonsense-mediated mRNA decay. The protein isoforms encoded by this gene are similar to its family member HNRPD. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1DNA unwinding involved in DNA replication (GO:0006268)4.82810989
2negative regulation of mRNA splicing, via spliceosome (GO:0048025)4.71686893
3mitotic sister chromatid cohesion (GO:0007064)4.43458471
4negative regulation of RNA splicing (GO:0033119)4.42768544
5negative regulation of mRNA processing (GO:0050686)4.21537783
6DNA double-strand break processing (GO:0000729)3.79848559
7protein localization to kinetochore (GO:0034501)3.73740720
8DNA ligation (GO:0006266)3.71382586
9pyrimidine nucleobase catabolic process (GO:0006208)3.70121152
10nuclear pore organization (GO:0006999)3.68017871
11kinetochore organization (GO:0051383)3.66061061
12nuclear pore complex assembly (GO:0051292)3.65238159
13negative regulation of mRNA metabolic process (GO:1903312)3.64663314
14mitotic chromosome condensation (GO:0007076)3.62896705
15pre-miRNA processing (GO:0031054)3.62172935
16DNA damage response, detection of DNA damage (GO:0042769)3.54807112
17presynaptic membrane assembly (GO:0097105)3.52451124
18DNA strand elongation involved in DNA replication (GO:0006271)3.45984781
19mRNA splice site selection (GO:0006376)3.45713792
20mRNA splicing, via spliceosome (GO:0000398)3.39149072
21RNA splicing, via transesterification reactions with bulged adenosine as nucleophile (GO:0000377)3.39149072
22establishment of integrated proviral latency (GO:0075713)3.38368562
23DNA topological change (GO:0006265)3.36616800
24DNA replication-independent nucleosome assembly (GO:0006336)3.35942507
25DNA replication-independent nucleosome organization (GO:0034724)3.35942507
26termination of RNA polymerase II transcription (GO:0006369)3.34946473
27RNA splicing, via transesterification reactions (GO:0000375)3.34927763
28DNA replication initiation (GO:0006270)3.33990566
29regulation of single stranded viral RNA replication via double stranded DNA intermediate (GO:00450913.33006791
30histone H2A acetylation (GO:0043968)3.32627409
31negative regulation of histone methylation (GO:0031061)3.32599729
32regulation of sister chromatid cohesion (GO:0007063)3.30712078
33mitotic metaphase plate congression (GO:0007080)3.30032108
34sister chromatid segregation (GO:0000819)3.27994206
35DNA duplex unwinding (GO:0032508)3.26983946
36DNA strand elongation (GO:0022616)3.26694738
37presynaptic membrane organization (GO:0097090)3.25315495
38DNA geometric change (GO:0032392)3.24546746
39DNA replication-dependent nucleosome assembly (GO:0006335)3.23517258
40DNA replication-dependent nucleosome organization (GO:0034723)3.23517258
41negative regulation of DNA-dependent DNA replication (GO:2000104)3.21954139
42kinetochore assembly (GO:0051382)3.19463101
43chromatin remodeling at centromere (GO:0031055)3.16081515
44CENP-A containing nucleosome assembly (GO:0034080)3.15696685
45metaphase plate congression (GO:0051310)3.14124390
46protein localization to chromosome, centromeric region (GO:0071459)3.11323824
47mitotic nuclear envelope disassembly (GO:0007077)3.11129011
48peptidyl-arginine omega-N-methylation (GO:0035247)3.09931351
49ATP-dependent chromatin remodeling (GO:0043044)3.07997409
50regulation of RNA export from nucleus (GO:0046831)3.07803104
51alternative mRNA splicing, via spliceosome (GO:0000380)3.06824553
52regulation of alternative mRNA splicing, via spliceosome (GO:0000381)3.06512661
53telomere maintenance via semi-conservative replication (GO:0032201)3.06501552
54limb bud formation (GO:0060174)3.06240524
55regulation of attachment of spindle microtubules to kinetochore (GO:0051988)3.05938712
56chromatin assembly or disassembly (GO:0006333)3.04896000
57mitotic recombination (GO:0006312)3.02754086
58spindle assembly checkpoint (GO:0071173)3.02133526
59regulation of histone H3-K9 methylation (GO:0051570)3.00383094
60RNA export from nucleus (GO:0006405)2.99823593
61negative regulation of DNA recombination (GO:0045910)2.99572219
62mitotic spindle assembly checkpoint (GO:0007094)2.98612458
63peptidyl-arginine methylation (GO:0018216)2.97577170
64peptidyl-arginine N-methylation (GO:0035246)2.97577170
65negative regulation of chromosome segregation (GO:0051985)2.96949505
66negative regulation of mitotic metaphase/anaphase transition (GO:0045841)2.96741425
67negative regulation of sister chromatid segregation (GO:0033046)2.96741425
68negative regulation of mitotic sister chromatid separation (GO:2000816)2.96741425
69negative regulation of mitotic sister chromatid segregation (GO:0033048)2.96741425
70mitotic sister chromatid segregation (GO:0000070)2.96583060
71spindle checkpoint (GO:0031577)2.96372956
72mRNA export from nucleus (GO:0006406)2.96348560
73translesion synthesis (GO:0019985)2.95221911
74membrane disassembly (GO:0030397)2.95066654
75nuclear envelope disassembly (GO:0051081)2.95066654
76mitotic spindle checkpoint (GO:0071174)2.94815724
77positive regulation of intracellular steroid hormone receptor signaling pathway (GO:0033145)2.93230595
78regulation of mRNA splicing, via spliceosome (GO:0048024)2.87910140
79negative regulation of metaphase/anaphase transition of cell cycle (GO:1902100)2.87751541
80histone exchange (GO:0043486)2.86901155
81regulation of chromosome segregation (GO:0051983)2.86358963
82regulation of helicase activity (GO:0051095)2.85913592
83regulation of spindle organization (GO:0090224)2.85772752
84dosage compensation (GO:0007549)2.85122445
85regulation of development, heterochronic (GO:0040034)2.83430932
86nucleobase catabolic process (GO:0046113)2.83136148
87regulation of mitotic spindle checkpoint (GO:1903504)2.82952132
88regulation of mitotic cell cycle spindle assembly checkpoint (GO:0090266)2.82952132
89regulation of centriole replication (GO:0046599)2.82667758
90paraxial mesoderm development (GO:0048339)2.82387580
91centriole replication (GO:0007099)2.81882345
92regulation of mitotic metaphase/anaphase transition (GO:0030071)2.81602779
93DNA replication checkpoint (GO:0000076)2.80668067
94peptidyl-lysine dimethylation (GO:0018027)2.80562205
95telomere maintenance via recombination (GO:0000722)2.80205765
96establishment of chromosome localization (GO:0051303)2.76846657
97regulation of DNA endoreduplication (GO:0032875)2.75508857
98mRNA transport (GO:0051028)2.75108085
99regulation of metaphase/anaphase transition of cell cycle (GO:1902099)2.75000110
100microtubule depolymerization (GO:0007019)2.74168630
101neural tube formation (GO:0001841)2.73935677
102regulation of nuclear cell cycle DNA replication (GO:0033262)2.73921394
103DNA conformation change (GO:0071103)2.73771472
104glucocorticoid receptor signaling pathway (GO:0042921)2.72951201
105protein-DNA complex disassembly (GO:0032986)2.71683568
106nucleosome disassembly (GO:0006337)2.71683568
107regulation of DNA damage checkpoint (GO:2000001)2.71677231
108regulation of sister chromatid segregation (GO:0033045)2.71658458
109regulation of mitotic sister chromatid separation (GO:0010965)2.71658458
110regulation of mitotic sister chromatid segregation (GO:0033047)2.71658458
111non-recombinational repair (GO:0000726)2.69647435
112double-strand break repair via nonhomologous end joining (GO:0006303)2.69647435
113forebrain neuron differentiation (GO:0021879)2.69601195
114replication fork processing (GO:0031297)2.68473399
115organelle disassembly (GO:1903008)2.68270963
116resolution of meiotic recombination intermediates (GO:0000712)2.66821535
117RNA splicing (GO:0008380)2.66379104
118attachment of spindle microtubules to kinetochore (GO:0008608)2.66345462
119protein localization to chromosome (GO:0034502)2.66123005
120histone H4-K8 acetylation (GO:0043982)2.65705623
121histone H4-K5 acetylation (GO:0043981)2.65705623
122neuron cell-cell adhesion (GO:0007158)2.64659434
123meiotic chromosome segregation (GO:0045132)2.64069663
124nucleotide-excision repair, DNA gap filling (GO:0006297)2.63521901
125histone mRNA metabolic process (GO:0008334)2.63469260
126spliceosomal tri-snRNP complex assembly (GO:0000244)2.62935423
127regulation of RNA splicing (GO:0043484)2.62100910
128intraciliary transport (GO:0042073)2.60616716
129somite development (GO:0061053)2.59748368
130nonmotile primary cilium assembly (GO:0035058)2.58502536
131spliceosomal snRNP assembly (GO:0000387)2.55270119
132spermatid nucleus differentiation (GO:0007289)2.55126114
133cullin deneddylation (GO:0010388)2.54382589
134DNA catabolic process, exonucleolytic (GO:0000738)2.53535160
135positive regulation of RNA splicing (GO:0033120)2.53107959
136establishment of protein localization to mitochondrial membrane (GO:0090151)2.51950845
137olfactory bulb development (GO:0021772)2.50687466
138DNA-templated transcription, termination (GO:0006353)2.49052894
139negative regulation of translation, ncRNA-mediated (GO:0040033)2.47854993
140regulation of translation, ncRNA-mediated (GO:0045974)2.47854993
141negative regulation of translation involved in gene silencing by miRNA (GO:0035278)2.47854993
142maintenance of fidelity involved in DNA-dependent DNA replication (GO:0045005)2.47800066
143regulation of mRNA processing (GO:0050684)2.47303254
144ribonucleoprotein complex disassembly (GO:0032988)2.47261593
145somatic hypermutation of immunoglobulin genes (GO:0016446)2.46324052
146somatic diversification of immune receptors via somatic mutation (GO:0002566)2.46324052
147V(D)J recombination (GO:0033151)2.45348316
148positive regulation of mRNA processing (GO:0050685)2.41139918
149microtubule anchoring (GO:0034453)2.41111299
150establishment of viral latency (GO:0019043)2.39587823
151exonucleolytic nuclear-transcribed mRNA catabolic process involved in deadenylation-dependent decay 2.38025937

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1FOXM1_23109430_ChIP-Seq_U2OS_Human5.52513026
2E2F4_17652178_ChIP-ChIP_JURKAT_Human4.45738068
3MYC_18555785_ChIP-Seq_MESCs_Mouse3.85504532
4FOXM1_25889361_ChIP-Seq_OE33_AND_U2OS_Human3.41629499
5EGR1_19374776_ChIP-ChIP_THP-1_Human3.13489485
6KDM5B_21448134_ChIP-Seq_MESCs_Mouse2.94941764
7MYC_19079543_ChIP-ChIP_MESCs_Mouse2.87938392
8TP63_19390658_ChIP-ChIP_HaCaT_Human2.74128813
9ZNF274_21170338_ChIP-Seq_K562_Hela2.57022244
10IGF1R_20145208_ChIP-Seq_DFB_Human2.51063076
11EKLF_21900194_ChIP-Seq_ERYTHROCYTE_Mouse2.47313731
12MYC_19030024_ChIP-ChIP_MESCs_Mouse2.46232024
13CIITA_25753668_ChIP-Seq_RAJI_Human2.40035087
14HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse2.39654970
15POU3F2_20337985_ChIP-ChIP_501MEL_Human2.38316195
16TAF15_26573619_Chip-Seq_HEK293_Human2.37795758
17E2F1_21310950_ChIP-Seq_MCF-7_Human2.37373852
18MYC_22102868_ChIP-Seq_BL_Human2.34390116
19XRN2_22483619_ChIP-Seq_HELA_Human2.29673970
20RBPJ_22232070_ChIP-Seq_NCS_Mouse2.26512406
21HCFC1_20581084_ChIP-Seq_MESCs_Mouse2.24864128
22AR_21909140_ChIP-Seq_LNCAP_Human2.24106489
23GLI1_17442700_ChIP-ChIP_MESCs_Mouse2.23144305
24SALL1_21062744_ChIP-ChIP_HESCs_Human2.22345734
25YY1_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse2.14693052
26NELFA_20434984_ChIP-Seq_ESCs_Mouse2.10618779
27E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse2.06154785
28MYBL2_22936984_ChIP-ChIP_MESCs_Mouse2.02197153
29MYC_18358816_ChIP-ChIP_MESCs_Mouse2.00214130
30E2F7_22180533_ChIP-Seq_HELA_Human10.1360817
31ZFP57_27257070_Chip-Seq_ESCs_Mouse1.98427904
32CEBPD_23245923_ChIP-Seq_MEFs_Mouse1.89945637
33MYCN_18555785_ChIP-Seq_MESCs_Mouse1.88589448
34TTF2_22483619_ChIP-Seq_HELA_Human1.88554443
35MYBL1_21750041_ChIP-ChIP_SPERMATOCYTES_Mouse1.85217194
36GBX2_23144817_ChIP-Seq_PC3_Human1.83837856
37EST1_17652178_ChIP-ChIP_JURKAT_Human1.78788754
38NR4A2_19515692_ChIP-ChIP_MN9D_Mouse1.76360629
39CDKN2AIP_20523734_ChIP-Seq_CORTICAL_Neurons1.75760845
40VDR_22108803_ChIP-Seq_LS180_Human1.74268007
41HOXD13_18407260_ChIP-ChIP_DEVELOPING-LIMBS_Mouse1.73424655
42CTBP2_25329375_ChIP-Seq_LNCAP_Human1.72366685
43ETS1_20019798_ChIP-Seq_JURKAT_Human1.70617489
44EZH2_22144423_ChIP-Seq_EOC_Human1.70279864
45P300_19829295_ChIP-Seq_ESCs_Human1.69755147
46CHD1_19587682_ChIP-ChIP_MESCs_Mouse1.62649928
47PPARG_23326641_ChIP-Seq_C3H10T1-2_Mouse1.60713607
48ZFP281_18358816_ChIP-ChIP_MESCs_Mouse1.59254231
49MYCN_21190229_ChIP-Seq_SHEP-21N_Human1.58004642
50ZFX_18555785_ChIP-Seq_MESCs_Mouse1.57399798
51CBX2_27304074_Chip-Seq_ESCs_Mouse1.56752888
52CREB1_23762244_ChIP-Seq_HIPPOCAMPUS_Rat1.56630430
53FLI1_27457419_Chip-Seq_LIVER_Mouse1.56466375
54KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human1.55546076
55VDR_23849224_ChIP-Seq_CD4+_Human1.55059699
56CTBP1_25329375_ChIP-Seq_LNCAP_Human1.54906399
57THAP11_20581084_ChIP-Seq_MESCs_Mouse1.54016848
58CREB1_15753290_ChIP-ChIP_HEK293T_Human1.53489689
59RNF2_27304074_Chip-Seq_NSC_Mouse1.52797715
60SOX2_18555785_ChIP-Seq_MESCs_Mouse1.49842876
61KDM5A_27292631_Chip-Seq_BREAST_Human1.43675281
62TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.43472418
63CCND1_20090754_ChIP-ChIP_RETINA_Mouse1.42899023
64CREM_20920259_ChIP-Seq_GC1-SPG_Mouse1.41666115
65GABP_17652178_ChIP-ChIP_JURKAT_Human1.41554980
66FOXP3_21729870_ChIP-Seq_TREG_Human1.40183677
67GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.39570690
68GABP_19822575_ChIP-Seq_HepG2_Human1.37724433
69POU5F1_18555785_ChIP-Seq_MESCs_Mouse1.35372047
70DMRT1_21621532_ChIP-ChIP_FETAL_Ovary1.34872206
71KLF4_19030024_ChIP-ChIP_MESCs_Mouse1.33799363
72DCP1A_22483619_ChIP-Seq_HELA_Human1.32672522
73PKCTHETA_26484144_Chip-Seq_BREAST_Human1.30154984
74SMARCA4_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.28786550
75MEIS1_26253404_ChIP-Seq_OPTIC_CUPS_Mouse1.28546138
76NUCKS1_24931609_ChIP-Seq_HEPATOCYTES_Mouse1.27912252
77OLIG2_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.25525173
78SOX2_16153702_ChIP-ChIP_HESCs_Human1.25342075
79ZFP42_18358816_ChIP-ChIP_MESCs_Mouse1.24056724
80NANOG_18555785_ChIP-Seq_MESCs_Mouse1.23863705
81NANOG_21062744_ChIP-ChIP_HESCs_Human1.23622010
82MYC_20876797_ChIP-ChIP_MEDULLOBLASTOMA_Human1.23531575
83E2F1_18555785_ChIP-Seq_MESCs_Mouse1.22689131
84ELK1_19687146_ChIP-ChIP_HELA_Human1.21845645
85FOXP2_21765815_ChIP-ChIP_NEURO2A_Mouse1.21155417
86TCF3_18467660_ChIP-ChIP_MESCs_Mouse1.21126496
87SALL4_18804426_ChIP-ChIP_MESCs_Mouse1.20729197
88PCGF2_27294783_Chip-Seq_ESCs_Mouse1.20022988
89FOXO3_22982991_ChIP-Seq_MACROPHAGES_Mouse1.19181607
90E2F4_21247883_ChIP-Seq_LYMPHOBLASTOID_Human1.19113716
91CNOT3_19339689_ChIP-ChIP_MESCs_Mouse1.17316431
92TOP2B_26459242_ChIP-Seq_MCF-7_Human1.16604634
93PADI4_21655091_ChIP-ChIP_MCF-7_Human1.16538915
94SMAD3_21741376_ChIP-Seq_EPCs_Human1.16148303
95TAL1_20887958_ChIP-Seq_HPC-7_Mouse1.14657604
96POU5F1_16153702_ChIP-ChIP_HESCs_Human1.14625199
97RCOR1_19997604_ChIP-ChIP_NEURONS_Mouse1.14445500
98SMAD1_18555785_ChIP-Seq_MESCs_Mouse1.13921044
99UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human1.13881067
100POU5F1_26923725_Chip-Seq_MESODERM_Mouse1.12671655
101TEAD4_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.12671655
102IRF1_19129219_ChIP-ChIP_H3396_Human1.12671238
103SOX2_19030024_ChIP-ChIP_MESCs_Mouse1.12555834
104PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human1.12275933
105ASXL1_24218140_ChIP-Seq_BMDM_Mouse1.11998783
106DMRT1_23473982_ChIP-Seq_TESTES_Mouse1.11075299
107JARID1A_20064375_ChIP-Seq_MESCs_Mouse1.10547082
108ZFP322A_24550733_ChIP-Seq_MESCs_Mouse1.09394492
109NOTCH1_21737748_ChIP-Seq_TLL_Human1.09299011
110ZFP281_27345836_Chip-Seq_ESCs_Mouse1.08446502
111CREB1_20920259_ChIP-Seq_GC1-SPG_Mouse1.07796339
112ZFP281_18757296_ChIP-ChIP_E14_Mouse1.07690163
113BMI1_23680149_ChIP-Seq_NPCS_Mouse1.07536086
114AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human1.07422426
115DACH1_20351289_ChIP-Seq_MDA-MB-231_Human1.07334828
116SMARCD1_25818293_ChIP-Seq_ESCs_Mouse1.07208871
117GRHL2_25758223_ChIP-Seq_PLACENTA_Mouse1.05914608
118VDR_21846776_ChIP-Seq_THP-1_Human1.05828226
119PRDM5_23873026_ChIP-Seq_MEFs_Mouse1.05713693
120SMAD2/3_21741376_ChIP-Seq_EPCs_Human1.04451108
121CHD1_26751641_Chip-Seq_LNCaP_Human1.04293728
122SOX9_26525672_Chip-Seq_HEART_Mouse1.03522738
123IRF4_20064451_ChIP-Seq_CD4+T_Mouse1.02901985
124CBP_20019798_ChIP-Seq_JUKART_Human1.02901985
125EWS_26573619_Chip-Seq_HEK293_Human1.02665939
126PCGF2_27294783_Chip-Seq_NPCs_Mouse1.02486423
127KLF4_18555785_ChIP-Seq_MESCs_Mouse1.01965529
128SMAD4_21799915_ChIP-Seq_A2780_Human1.00801583
129NOTCH1_17114293_ChIP-ChIP_T-ALL_Human1.00622139
130POU5F1_18358816_ChIP-ChIP_MESCs_Mouse0.99999149
131FOXM1_26100407_CHIP-SEQ_Hek293_flp-in_Human0.98882373
132PIAS1_25552417_ChIP-Seq_VCAP_Human0.98280094
133NANOG_18555785_Chip-Seq_ESCs_Mouse0.96505321
134KLF5_20875108_ChIP-Seq_MESCs_Mouse0.96386229
135TCFCP2L1_18555785_Chip-Seq_ESCs_Mouse0.96221928
136STAT6_21828071_ChIP-Seq_BEAS2B_Human0.95854394
137WT1_19549856_ChIP-ChIP_CCG9911_Human0.95664527
138TRIM28_19339689_ChIP-ChIP_MESCs_Mouse0.95183586
139HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human0.94523632
140ZIC3_20872845_ChIP-ChIP_MESCs_Mouse0.92578362
141SOX9_22984422_ChIP-ChIP_TESTIS_Rat0.91222305
142MYC_18940864_ChIP-ChIP_HL60_Human0.88093844
143ELF1_17652178_ChIP-ChIP_JURKAT_Human0.86762301
144FUS_26573619_Chip-Seq_HEK293_Human0.84551873
145TCF7_22412390_ChIP-Seq_EML_Mouse0.83545420
146HOXB4_20404135_ChIP-ChIP_EML_Mouse0.82298355
147NANOG_16153702_ChIP-ChIP_HESCs_Human0.82255040
148WT1_20215353_ChIP-ChIP_NEPHRON_PROGENITOR_Mouse0.82152869
149POU5F1_18347094_ChIP-ChIP_MESCs_Mouse0.81265059
150KDM2B_26808549_Chip-Seq_DND41_Human0.80736775
151SPI1_22790984_ChIP-Seq_ERYTHROLEUKEMIA_Mouse0.80655832
152YY1_21170310_ChIP-Seq_MESCs_Mouse0.80405425

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0010094_abnormal_chromosome_stability3.30531694
2MP0003693_abnormal_embryo_hatching3.29948591
3MP0003111_abnormal_nucleus_morphology3.05714145
4MP0008057_abnormal_DNA_replication3.04525984
5MP0003880_abnormal_central_pattern2.84940747
6MP0000537_abnormal_urethra_morphology2.84904704
7MP0004957_abnormal_blastocyst_morpholog2.81857097
8MP0003077_abnormal_cell_cycle2.79406349
9MP0003123_paternal_imprinting2.71157174
10MP0003121_genomic_imprinting2.59269654
11MP0001529_abnormal_vocalization2.40173880
12MP0008058_abnormal_DNA_repair2.37135407
13MP0001188_hyperpigmentation2.14512571
14MP0008007_abnormal_cellular_replicative2.09220999
15MP0008877_abnormal_DNA_methylation2.06653236
16MP0010030_abnormal_orbit_morphology2.06463525
17MP0002102_abnormal_ear_morphology2.05646117
18MP0003890_abnormal_embryonic-extraembry2.05640806
19MP0006292_abnormal_olfactory_placode2.02911045
20MP0003122_maternal_imprinting1.90992356
21MP0001730_embryonic_growth_arrest1.89214534
22MP0000350_abnormal_cell_proliferation1.84700177
23MP0003787_abnormal_imprinting1.83047971
24MP0008932_abnormal_embryonic_tissue1.81398574
25MP0002084_abnormal_developmental_patter1.74448368
26MP0002085_abnormal_embryonic_tissue1.71718835
27MP0008995_early_reproductive_senescence1.71410818
28MP0003119_abnormal_digestive_system1.68355132
29MP0001293_anophthalmia1.67417561
30MP0005076_abnormal_cell_differentiation1.66681666
31MP0009053_abnormal_anal_canal1.62728754
32MP0000569_abnormal_digit_pigmentation1.61258034
33MP0001984_abnormal_olfaction1.59010331
34MP0004197_abnormal_fetal_growth/weight/1.58832592
35MP0001697_abnormal_embryo_size1.55421456
36MP0002938_white_spotting1.52290261
37MP0002653_abnormal_ependyma_morphology1.51541597
38MP0005380_embryogenesis_phenotype1.50883237
39MP0001672_abnormal_embryogenesis/_devel1.50883237
40MP0003937_abnormal_limbs/digits/tail_de1.50658050
41MP0005423_abnormal_somatic_nervous1.50064033
42MP0000049_abnormal_middle_ear1.47055469
43MP0008789_abnormal_olfactory_epithelium1.46052884
44MP0004859_abnormal_synaptic_plasticity1.43854624
45MP0000428_abnormal_craniofacial_morphol1.42746269
46MP0003861_abnormal_nervous_system1.42039115
47MP0003984_embryonic_growth_retardation1.38642990
48MP0003567_abnormal_fetal_cardiomyocyte1.38197191
49MP0002088_abnormal_embryonic_growth/wei1.36400418
50MP0004808_abnormal_hematopoietic_stem1.34704625
51MP0002736_abnormal_nociception_after1.34363811
52MP0002396_abnormal_hematopoietic_system1.32201505
53MP0005253_abnormal_eye_physiology1.31208021
54MP0001177_atelectasis1.30720527
55MP0003283_abnormal_digestive_organ1.30254776
56MP0006276_abnormal_autonomic_nervous1.29747691
57MP0001486_abnormal_startle_reflex1.29573909
58MP0004885_abnormal_endolymph1.29539641
59MP0002080_prenatal_lethality1.29397436
60MP0002638_abnormal_pupillary_reflex1.29249667
61MP0010352_gastrointestinal_tract_polyps1.28585633
62MP0003935_abnormal_craniofacial_develop1.28544998
63MP0005394_taste/olfaction_phenotype1.28499080
64MP0005499_abnormal_olfactory_system1.28499080
65MP0002184_abnormal_innervation1.25254821
66MP0009672_abnormal_birth_weight1.24990207
67MP0003755_abnormal_palate_morphology1.24190938
68MP0000778_abnormal_nervous_system1.22893941
69MP0002086_abnormal_extraembryonic_tissu1.22813700
70MP0000955_abnormal_spinal_cord1.21479685
71MP0002822_catalepsy1.18299669
72MP0009703_decreased_birth_body1.17923718
73MP0003136_yellow_coat_color1.15919006
74MP0003635_abnormal_synaptic_transmissio1.15883878
75MP0005187_abnormal_penis_morphology1.15212540
76MP0003115_abnormal_respiratory_system1.14712826
77MP0004270_analgesia1.14290158
78MP0002932_abnormal_joint_morphology1.12623448
79MP0002116_abnormal_craniofacial_bone1.12323924
80MP0003315_abnormal_perineum_morphology1.10608425
81MP0006054_spinal_hemorrhage1.09667246
82MP0003938_abnormal_ear_development1.08546969
83MP0001286_abnormal_eye_development1.08220313
84MP0002272_abnormal_nervous_system1.07790742
85MP0003385_abnormal_body_wall1.07079949
86MP0009745_abnormal_behavioral_response1.05207248
87MP0002092_abnormal_eye_morphology1.05095929
88MP0002063_abnormal_learning/memory/cond1.04541794
89MP0000631_abnormal_neuroendocrine_gland1.04415016
90MP0003942_abnormal_urinary_system1.03895038
91MP0001968_abnormal_touch/_nociception1.03395212
92MP0002557_abnormal_social/conspecific_i1.03351299
93MP0002735_abnormal_chemical_nociception1.03314924
94MP0000383_abnormal_hair_follicle1.02345513
95MP0002734_abnormal_mechanical_nocicepti1.01923904
96MP0000432_abnormal_head_morphology1.01105211
97MP0004811_abnormal_neuron_physiology1.00705018
98MP0002234_abnormal_pharynx_morphology1.00031310
99MP0002210_abnormal_sex_determination0.99910898
100MP0005645_abnormal_hypothalamus_physiol0.99632995
101MP0009046_muscle_twitch0.98765687
102MP0002009_preneoplasia0.97954978
103MP0000733_abnormal_muscle_development0.96965743
104MP0000313_abnormal_cell_death0.96063013
105MP0002572_abnormal_emotion/affect_behav0.95807534
106MP0002081_perinatal_lethality0.95732268
107MP0000566_synostosis0.95671139
108MP0001485_abnormal_pinna_reflex0.95394458
109MP0010307_abnormal_tumor_latency0.95077463
110MP0004142_abnormal_muscle_tone0.94294092
111MP0002752_abnormal_somatic_nervous0.94026937
112MP0002233_abnormal_nose_morphology0.94001569
113MP0002114_abnormal_axial_skeleton0.93835191
114MP0001299_abnormal_eye_distance/0.93244500
115MP0010678_abnormal_skin_adnexa0.92537484
116MP0002751_abnormal_autonomic_nervous0.91907718
117MP0003221_abnormal_cardiomyocyte_apopto0.91355421
118MP0002111_abnormal_tail_morphology0.90657191
119MP0002249_abnormal_larynx_morphology0.90503235
120MP0002697_abnormal_eye_size0.90238287
121MP0004133_heterotaxia0.89114534
122MP0002882_abnormal_neuron_morphology0.88730626
123MP0000516_abnormal_urinary_system0.88692711
124MP0005367_renal/urinary_system_phenotyp0.88692711
125MP0000647_abnormal_sebaceous_gland0.87560127
126MP0003786_premature_aging0.87342489
127MP0005551_abnormal_eye_electrophysiolog0.86992520
128MP0001929_abnormal_gametogenesis0.86797291
129MP0002067_abnormal_sensory_capabilities0.86504047
130MP0004742_abnormal_vestibular_system0.85890882
131MP0000703_abnormal_thymus_morphology0.85498435
132MP0000534_abnormal_ureter_morphology0.85169905
133MP0004233_abnormal_muscle_weight0.83438523
134MP0001145_abnormal_male_reproductive0.82642162
135MP0006072_abnormal_retinal_apoptosis0.81477594
136MP0009250_abnormal_appendicular_skeleto0.80058112
137MP0002925_abnormal_cardiovascular_devel0.78687295
138MP0002152_abnormal_brain_morphology0.78428063
139MP0001849_ear_inflammation0.76333232
140MP0002177_abnormal_outer_ear0.75245352
141MP0009278_abnormal_bone_marrow0.70401583
142MP0000490_abnormal_crypts_of0.69806797
143MP0005391_vision/eye_phenotype0.69785644
144MP0002282_abnormal_trachea_morphology0.69629561
145MP0000653_abnormal_sex_gland0.68949912
146MP0010234_abnormal_vibrissa_follicle0.67027349

Predicted human phenotypes

RankGene SetZ-score
1Volvulus (HP:0002580)3.94820463
2Short 4th metacarpal (HP:0010044)3.46383069
3Aplasia/Hypoplasia of the 4th metacarpal (HP:0010042)3.46383069
4Colon cancer (HP:0003003)3.18777781
5Selective tooth agenesis (HP:0001592)3.11129968
6Ependymoma (HP:0002888)3.04445700
7Increased nuchal translucency (HP:0010880)3.01145651
8Medulloblastoma (HP:0002885)2.88796694
9Abnormality of the labia minora (HP:0012880)2.75915526
10Abnormal number of incisors (HP:0011064)2.72322556
11Cortical dysplasia (HP:0002539)2.72097417
12Renal duplication (HP:0000075)2.70671550
13Birth length less than 3rd percentile (HP:0003561)2.55480724
14Abnormality of the astrocytes (HP:0100707)2.51062032
15Astrocytoma (HP:0009592)2.51062032
16Aplasia/Hypoplasia of the sternum (HP:0006714)2.50238420
17Patellar aplasia (HP:0006443)2.49938354
18True hermaphroditism (HP:0010459)2.48877570
19Abnormality of the 4th metacarpal (HP:0010012)2.43455590
20Short middle phalanx of the 5th finger (HP:0004220)2.41277775
21Long eyelashes (HP:0000527)2.37283533
22Hepatoblastoma (HP:0002884)2.36263522
23Aplasia/Hypoplasia of the patella (HP:0006498)2.36166813
24Medial flaring of the eyebrow (HP:0010747)2.35573730
25Proximal placement of thumb (HP:0009623)2.35431001
26Septo-optic dysplasia (HP:0100842)2.34525239
27Facial hemangioma (HP:0000329)2.29144106
28Abnormality of the fingertips (HP:0001211)2.26674278
29Glioma (HP:0009733)2.25883385
30Pancreatic cysts (HP:0001737)2.25279873
31Nephronophthisis (HP:0000090)2.23667134
32Oligodactyly (HP:0012165)2.22703020
33Gait imbalance (HP:0002141)2.22062992
34Atresia of the external auditory canal (HP:0000413)2.21932501
35Pancreatic fibrosis (HP:0100732)2.21925544
36Deviation of the thumb (HP:0009603)2.19147590
37Molar tooth sign on MRI (HP:0002419)2.18268066
38Abnormality of midbrain morphology (HP:0002418)2.18268066
39Drooling (HP:0002307)2.17890209
40Hyperacusis (HP:0010780)2.13923889
41Obsessive-compulsive behavior (HP:0000722)2.13686614
42Congenital primary aphakia (HP:0007707)2.12980271
43Supernumerary spleens (HP:0009799)2.11991325
44Ectopic kidney (HP:0000086)2.11912069
45Overriding aorta (HP:0002623)2.07224562
46Genital tract atresia (HP:0001827)2.06548885
47Neoplasm of the oral cavity (HP:0100649)2.04310116
48Broad thumb (HP:0011304)2.02952869
49Trigonocephaly (HP:0000243)2.02616606
50Optic nerve hypoplasia (HP:0000609)2.02152119
51Vaginal atresia (HP:0000148)2.00975595
52Abnormal lung lobation (HP:0002101)1.98772170
53Focal motor seizures (HP:0011153)1.97767626
54Abnormality of chromosome segregation (HP:0002916)1.97755895
55Neoplasm of striated muscle (HP:0009728)1.96748685
56Triphalangeal thumb (HP:0001199)1.94846616
57Excessive salivation (HP:0003781)1.93523675
58Prominent nose (HP:0000448)1.92296681
59Gastrointestinal atresia (HP:0002589)1.92178396
60Nephrogenic diabetes insipidus (HP:0009806)1.91825548
61Abnormality of the corticospinal tract (HP:0002492)1.91117568
62Rhabdomyosarcoma (HP:0002859)1.90831236
63Renovascular hypertension (HP:0100817)1.89560625
64Hypoplastic labia majora (HP:0000059)1.88091298
65Broad alveolar ridges (HP:0000187)1.87879155
66Gonadotropin excess (HP:0000837)1.87481748
67High anterior hairline (HP:0009890)1.86834064
68Reticulocytopenia (HP:0001896)1.86528202
69Abnormality of the renal medulla (HP:0100957)1.85319241
70Atrophy/Degeneration involving the corticospinal tracts (HP:0007372)1.83630543
71Degeneration of the lateral corticospinal tracts (HP:0002314)1.83630543
72Sacral dimple (HP:0000960)1.82740845
73Pointed chin (HP:0000307)1.82448799
74Nephroblastoma (Wilms tumor) (HP:0002667)1.82045950
75Preaxial hand polydactyly (HP:0001177)1.81748057
76Abnormality of the septum pellucidum (HP:0007375)1.81139735
77Chromsome breakage (HP:0040012)1.81002712
78Postaxial hand polydactyly (HP:0001162)1.80691088
79Sloping forehead (HP:0000340)1.79653280
80Narrow forehead (HP:0000341)1.79491589
81Supernumerary ribs (HP:0005815)1.79435680
82Limb dystonia (HP:0002451)1.79028352
83Aplasia/Hypoplasia of the optic nerve (HP:0008058)1.78635448
84Anophthalmia (HP:0000528)1.78194959
85Postaxial foot polydactyly (HP:0001830)1.77965780
86Elfin facies (HP:0004428)1.77849596
87Absent septum pellucidum (HP:0001331)1.77726363
88Aplasia/Hypoplasia of the uvula (HP:0010293)1.77357650
89Renal hypoplasia (HP:0000089)1.76941703
90Hyperglycinemia (HP:0002154)1.76608832
91Short 5th finger (HP:0009237)1.76400867
92Abnormality of the duodenum (HP:0002246)1.75646222
93Basal cell carcinoma (HP:0002671)1.75517142
94Missing ribs (HP:0000921)1.75342744
95Papillary thyroid carcinoma (HP:0002895)1.75179612
96Malignant gastrointestinal tract tumors (HP:0006749)1.74991914
97Gastrointestinal carcinoma (HP:0002672)1.74991914
98Broad phalanges of the hand (HP:0009768)1.74808985
99Abnormality of chromosome stability (HP:0003220)1.74390284
100Rib fusion (HP:0000902)1.73215050
101Duodenal stenosis (HP:0100867)1.72942506
102Small intestinal stenosis (HP:0012848)1.72942506
103Degeneration of anterior horn cells (HP:0002398)1.72532501
104Abnormality of the anterior horn cell (HP:0006802)1.72532501
105Abdominal situs inversus (HP:0003363)1.72457590
106Abnormality of abdominal situs (HP:0011620)1.72457590
107Acute lymphatic leukemia (HP:0006721)1.72429256
108Shallow orbits (HP:0000586)1.71547128
109Oligodactyly (hands) (HP:0001180)1.71247019
110Meckel diverticulum (HP:0002245)1.71130439
111Abnormality of the ileum (HP:0001549)1.71128364
112Insomnia (HP:0100785)1.70667303
113Aplasia/Hypoplasia of the 5th finger (HP:0006262)1.70629277
114Esophageal atresia (HP:0002032)1.70321180
115Aqueductal stenosis (HP:0002410)1.70086844
116Embryonal renal neoplasm (HP:0011794)1.69868450
117Overlapping toe (HP:0001845)1.69155627
118Ankyloglossia (HP:0010296)1.68263535
119Amyotrophic lateral sclerosis (HP:0007354)1.68207846
120Abnormality of the columella (HP:0009929)1.68092804
121Specific learning disability (HP:0001328)1.67745876
122Abnormality of the labia majora (HP:0012881)1.67141324
123Abnormality of the carotid arteries (HP:0005344)1.66856878
124Supernumerary bones of the axial skeleton (HP:0009144)1.66730389
125Bifid tongue (HP:0010297)1.66376586
126Skin tags (HP:0010609)1.66237901
127Absent radius (HP:0003974)1.66066432
128Abnormality of the diencephalon (HP:0010662)1.65499988
12911 pairs of ribs (HP:0000878)1.65358169
130Long clavicles (HP:0000890)1.65130730
131Intestinal atresia (HP:0011100)1.65004909
132Broad-based gait (HP:0002136)1.64499310
133Retinal dysplasia (HP:0007973)1.63299396
134Broad foot (HP:0001769)1.63217240
135Dandy-Walker malformation (HP:0001305)1.62989820
136Poor coordination (HP:0002370)1.62960810
137Aplasia involving forearm bones (HP:0009822)1.62601004
138Absent forearm bone (HP:0003953)1.62601004
139Abnormality of the preputium (HP:0100587)1.62447116
140Chromosomal breakage induced by crosslinking agents (HP:0003221)1.61678422
141Heterotopia (HP:0002282)1.61517912
142Anal stenosis (HP:0002025)1.61138720
143Anencephaly (HP:0002323)1.60985251
144Neoplasm of the pancreas (HP:0002894)1.60773493
145Cafe-au-lait spot (HP:0000957)1.60586340
146Midline defect of the nose (HP:0004122)1.60266556
147Hemivertebrae (HP:0002937)1.60165480
148Pendular nystagmus (HP:0012043)1.59939562
149Lissencephaly (HP:0001339)1.59923813
150Broad finger (HP:0001500)1.59662181
151Decreased testicular size (HP:0008734)1.59503663
152Abnormality of the metopic suture (HP:0005556)1.59284651
153Aplasia/Hypoplasia of the middle phalanx of the 5th finger (HP:0009161)1.59050919
154Flat cornea (HP:0007720)1.58793956
155Small hand (HP:0200055)1.58687370
156Myelodysplasia (HP:0002863)1.58561635
157Atrophy/Degeneration involving motor neurons (HP:0007373)1.58395758
158Progressive inability to walk (HP:0002505)1.58290948
159Optic nerve coloboma (HP:0000588)1.58181431
160Acute necrotizing encephalopathy (HP:0006965)1.57805689
161Methylmalonic acidemia (HP:0002912)1.57386787
162Bilateral microphthalmos (HP:0007633)1.56801738
163Increased hepatocellular lipid droplets (HP:0006565)1.56611769
164Abnormality of the lower motor neuron (HP:0002366)1.55927342
165Split foot (HP:0001839)1.55584504
166Cupped ear (HP:0000378)1.55347040
167Micropenis (HP:0000054)1.54832207
168Tubulointerstitial nephritis (HP:0001970)1.54329853
169Embryonal neoplasm (HP:0002898)1.54171436

Predicted kinase interactions (KEA)

RankGene SetZ-score
1CDC75.38533526
2WEE12.84409441
3CDK122.77800320
4MKNK12.73306066
5ACVR1B2.67112298
6WNK32.60847196
7SRPK12.60637697
8BRD42.57230020
9NEK22.54409826
10BUB12.37697406
11TNIK2.36797800
12TRIM282.32120713
13PASK2.25722305
14DYRK32.16145180
15CASK2.11270869
16MKNK22.09143277
17PNCK2.05955322
18KSR11.95808617
19TTK1.91048846
20ATR1.90865269
21MAP3K101.84085048
22NEK11.69197283
23MAP4K21.66444819
24PLK31.63288485
25ERBB31.56475561
26BRSK21.53381253
27PLK11.52839865
28CDK71.50824463
29NUAK11.49248193
30MAP2K71.49200078
31TGFBR11.49056705
32CHEK11.45653582
33MARK11.45118867
34AURKB1.42409972
35TAF11.38345986
36VRK11.36306942
37RPS6KA41.33530492
38CHEK21.32045839
39BMPR1B1.30914040
40TSSK61.30417471
41CDK191.27538087
42CDK41.23761676
43CCNB11.23551617
44EIF2AK31.22949691
45EEF2K1.22473209
46BRSK11.21887275
47ATM1.19647783
48UHMK11.17657912
49CDK21.15952333
50ZAK1.15794527
51CDK61.14752933
52ALK1.11787198
53TYRO31.10169770
54MINK11.04854756
55SCYL21.00186525
56CDK11.00021002
57CDK30.99783510
58PINK10.98689334
59CDK80.97306579
60FGFR10.96915605
61RPS6KB20.94228712
62SIK20.90885156
63PLK20.90757898
64PAK40.89890356
65TESK20.87235783
66MELK0.83056637
67NTRK20.82848950
68MAP3K80.82267604
69CSNK1A1L0.81756193
70LATS10.79303736
71PLK40.79097292
72PBK0.74933470
73DYRK1A0.74900340
74PRKDC0.74750623
75MTOR0.73762316
76EIF2AK20.73740885
77EPHB20.73623647
78BCR0.73132833
79PRKCG0.71888611
80DYRK20.71359609
81CLK10.71081385
82EIF2AK10.70442845
83PDGFRA0.70270865
84AURKA0.68723131
85CSNK1E0.67892738
86ERBB20.67812523
87FGFR20.67536911
88NTRK30.66881103
89TLK10.60760538
90AKT30.60560260
91YES10.60189672
92MAPK140.60157500
93STK38L0.59409303
94CSNK1G30.58220464
95CSNK1G10.57384641
96MAPK90.57212939
97GSK3B0.56847267
98CSNK1D0.56353667
99STK100.55983032
100VRK20.54930214
101PKN20.54231588
102MAP2K40.52849955
103CSNK2A20.52165938
104MAPK100.51381373
105SIK30.50913352
106CAMK1G0.50491149
107EPHA40.50054685
108CSNK1G20.49788834
109HIPK20.49193212
110STK30.49047706
111AKT20.48395656
112MAPK80.46245942
113NME10.45451085
114FRK0.44437178
115PAK30.44209242
116SGK20.43613031
117OXSR10.43351588
118PAK20.43266290
119STK390.42393021
120CDK180.41907685
121NLK0.41458265
122CDK90.40640661
123AKT10.40352205
124MAPK130.40055934
125MAP3K40.40033041
126CDK140.39735119
127CDK11A0.39706811
128STK40.39446485
129TAOK20.39316786
130DYRK1B0.38629549
131PRKCI0.38611888
132CSNK2A10.37924995
133CDK150.37907953
134PRKCE0.36517193
135MAPK150.34517106
136INSRR0.33807328
137CDC42BPA0.33691283

Predicted pathways (KEGG)

RankGene SetZ-score
1DNA replication_Homo sapiens_hsa030303.69696372
2Spliceosome_Homo sapiens_hsa030403.57021720
3Protein export_Homo sapiens_hsa030603.33210812
4Mismatch repair_Homo sapiens_hsa034303.24016602
5RNA transport_Homo sapiens_hsa030132.71412585
6Cell cycle_Homo sapiens_hsa041102.67989834
7mRNA surveillance pathway_Homo sapiens_hsa030152.62855842
8Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030082.62217878
9Base excision repair_Homo sapiens_hsa034102.53059598
10Synthesis and degradation of ketone bodies_Homo sapiens_hsa000722.32942269
11Terpenoid backbone biosynthesis_Homo sapiens_hsa009002.20274394
12Nicotine addiction_Homo sapiens_hsa050332.14231500
13Homologous recombination_Homo sapiens_hsa034402.10962130
14Steroid biosynthesis_Homo sapiens_hsa001002.07255575
15Nucleotide excision repair_Homo sapiens_hsa034202.04134054
16RNA polymerase_Homo sapiens_hsa030201.88607107
17Fanconi anemia pathway_Homo sapiens_hsa034601.82722981
18Basal cell carcinoma_Homo sapiens_hsa052171.79404906
19RNA degradation_Homo sapiens_hsa030181.79166966
20Non-homologous end-joining_Homo sapiens_hsa034501.70482206
21Propanoate metabolism_Homo sapiens_hsa006401.69695915
22Ribosome_Homo sapiens_hsa030101.68560530
23Basal transcription factors_Homo sapiens_hsa030221.60009429
24Oocyte meiosis_Homo sapiens_hsa041141.53695011
25Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa009701.48980223
26Taurine and hypotaurine metabolism_Homo sapiens_hsa004301.48960190
27Parkinsons disease_Homo sapiens_hsa050121.47857988
28Progesterone-mediated oocyte maturation_Homo sapiens_hsa049141.46426828
29Oxidative phosphorylation_Homo sapiens_hsa001901.41955315
30Ubiquitin mediated proteolysis_Homo sapiens_hsa041201.40902721
31Colorectal cancer_Homo sapiens_hsa052101.37244068
32Hedgehog signaling pathway_Homo sapiens_hsa043401.33185391
33One carbon pool by folate_Homo sapiens_hsa006701.32127906
34Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005631.31428418
35MicroRNAs in cancer_Homo sapiens_hsa052061.30455876
36Hippo signaling pathway_Homo sapiens_hsa043901.28538967
37Pyrimidine metabolism_Homo sapiens_hsa002401.26919932
38Notch signaling pathway_Homo sapiens_hsa043301.25338680
39Wnt signaling pathway_Homo sapiens_hsa043101.22741422
40Phototransduction_Homo sapiens_hsa047441.22127762
41Butanoate metabolism_Homo sapiens_hsa006501.19727138
42p53 signaling pathway_Homo sapiens_hsa041151.19127731
43Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa045501.19054278
44Huntingtons disease_Homo sapiens_hsa050161.17835007
45HTLV-I infection_Homo sapiens_hsa051661.16001897
46Cysteine and methionine metabolism_Homo sapiens_hsa002701.05968430
47Epstein-Barr virus infection_Homo sapiens_hsa051691.02202683
48Herpes simplex infection_Homo sapiens_hsa051681.01474663
49Chronic myeloid leukemia_Homo sapiens_hsa052201.01022481
50Taste transduction_Homo sapiens_hsa047421.00516112
51GABAergic synapse_Homo sapiens_hsa047271.00068469
52Transcriptional misregulation in cancer_Homo sapiens_hsa052020.99439834
53Thyroid cancer_Homo sapiens_hsa052160.95205610
54Alcoholism_Homo sapiens_hsa050340.95039865
55Viral carcinogenesis_Homo sapiens_hsa052030.93045959
56Selenocompound metabolism_Homo sapiens_hsa004500.91611983
57Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001300.90234956
58TGF-beta signaling pathway_Homo sapiens_hsa043500.90233169
59Retrograde endocannabinoid signaling_Homo sapiens_hsa047230.88421369
60Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006300.87578575
61Valine, leucine and isoleucine degradation_Homo sapiens_hsa002800.86775583
62Glutamatergic synapse_Homo sapiens_hsa047240.86335770
63Endometrial cancer_Homo sapiens_hsa052130.86010225
64Systemic lupus erythematosus_Homo sapiens_hsa053220.85556136
65mTOR signaling pathway_Homo sapiens_hsa041500.85356693
66Morphine addiction_Homo sapiens_hsa050320.83427098
67Glycine, serine and threonine metabolism_Homo sapiens_hsa002600.83171253
68Lysine degradation_Homo sapiens_hsa003100.81723824
69Axon guidance_Homo sapiens_hsa043600.81619829
70Thyroid hormone signaling pathway_Homo sapiens_hsa049190.81215677
71Neuroactive ligand-receptor interaction_Homo sapiens_hsa040800.80694645
72Adherens junction_Homo sapiens_hsa045200.80615033
73Small cell lung cancer_Homo sapiens_hsa052220.79796610
74Melanogenesis_Homo sapiens_hsa049160.77613740
75Other types of O-glycan biosynthesis_Homo sapiens_hsa005140.77600086
76Non-small cell lung cancer_Homo sapiens_hsa052230.75596300
77Pathways in cancer_Homo sapiens_hsa052000.74074301
78Pathogenic Escherichia coli infection_Homo sapiens_hsa051300.72997419
79Pantothenate and CoA biosynthesis_Homo sapiens_hsa007700.70560651
80Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002500.69953662
81Alzheimers disease_Homo sapiens_hsa050100.67510638
82Proteoglycans in cancer_Homo sapiens_hsa052050.67367347
83Viral myocarditis_Homo sapiens_hsa054160.67013626
84Purine metabolism_Homo sapiens_hsa002300.66924228
85Long-term potentiation_Homo sapiens_hsa047200.66788612
86Proteasome_Homo sapiens_hsa030500.66625141
87Regulation of autophagy_Homo sapiens_hsa041400.66223645
88Olfactory transduction_Homo sapiens_hsa047400.66075220
89Neurotrophin signaling pathway_Homo sapiens_hsa047220.64306961
90Glioma_Homo sapiens_hsa052140.64305602
91Cardiac muscle contraction_Homo sapiens_hsa042600.64002748
92Prostate cancer_Homo sapiens_hsa052150.63343838
93Gap junction_Homo sapiens_hsa045400.61685514
94Hepatitis B_Homo sapiens_hsa051610.60902158
95Pancreatic cancer_Homo sapiens_hsa052120.60201271
96Renal cell carcinoma_Homo sapiens_hsa052110.58959294
97Pyruvate metabolism_Homo sapiens_hsa006200.58851123
98ErbB signaling pathway_Homo sapiens_hsa040120.57497129
99T cell receptor signaling pathway_Homo sapiens_hsa046600.55907389
100Bacterial invasion of epithelial cells_Homo sapiens_hsa051000.55558920
101Fc epsilon RI signaling pathway_Homo sapiens_hsa046640.54550641
102Dopaminergic synapse_Homo sapiens_hsa047280.54290378
103Antigen processing and presentation_Homo sapiens_hsa046120.53984016
104Vasopressin-regulated water reabsorption_Homo sapiens_hsa049620.53694132
105Bladder cancer_Homo sapiens_hsa052190.51674259
106Serotonergic synapse_Homo sapiens_hsa047260.51537298
107Ether lipid metabolism_Homo sapiens_hsa005650.50836005
108FoxO signaling pathway_Homo sapiens_hsa040680.50588497
109Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006010.50037345
110Estrogen signaling pathway_Homo sapiens_hsa049150.49816515
111Folate biosynthesis_Homo sapiens_hsa007900.49176162
112Acute myeloid leukemia_Homo sapiens_hsa052210.47625814
113Tight junction_Homo sapiens_hsa045300.46887307
114VEGF signaling pathway_Homo sapiens_hsa043700.46336110
115Maturity onset diabetes of the young_Homo sapiens_hsa049500.45841497
116MAPK signaling pathway_Homo sapiens_hsa040100.44694914
117B cell receptor signaling pathway_Homo sapiens_hsa046620.44331581
118Fc gamma R-mediated phagocytosis_Homo sapiens_hsa046660.44290884
119Shigellosis_Homo sapiens_hsa051310.43570480
120Amphetamine addiction_Homo sapiens_hsa050310.42435323
121Fatty acid elongation_Homo sapiens_hsa000620.42234543
122Long-term depression_Homo sapiens_hsa047300.41330247
123Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010400.41211322
124Cholinergic synapse_Homo sapiens_hsa047250.40259550
125Choline metabolism in cancer_Homo sapiens_hsa052310.40035921
126GnRH signaling pathway_Homo sapiens_hsa049120.38840897
127Longevity regulating pathway - mammal_Homo sapiens_hsa042110.38664529
128Central carbon metabolism in cancer_Homo sapiens_hsa052300.37986726
129Longevity regulating pathway - multiple species_Homo sapiens_hsa042130.36661716
130AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa049330.36458389
131Rap1 signaling pathway_Homo sapiens_hsa040150.36457260
132Vitamin B6 metabolism_Homo sapiens_hsa007500.35614296
133Arrhythmogenic right ventricular cardiomyopathy (ARVC)_Homo sapiens_hsa054120.35059715
134Nitrogen metabolism_Homo sapiens_hsa009100.34801378
135Oxytocin signaling pathway_Homo sapiens_hsa049210.34135360
136N-Glycan biosynthesis_Homo sapiens_hsa005100.33776086
137Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa005340.33252768
138Adrenergic signaling in cardiomyocytes_Homo sapiens_hsa042610.33115051
139Dorso-ventral axis formation_Homo sapiens_hsa043200.33067453
140PI3K-Akt signaling pathway_Homo sapiens_hsa041510.31635746
141Insulin secretion_Homo sapiens_hsa049110.31302851
142Circadian entrainment_Homo sapiens_hsa047130.31144444
143Circadian rhythm_Homo sapiens_hsa047100.30377297
144Prolactin signaling pathway_Homo sapiens_hsa049170.29600156
145Cocaine addiction_Homo sapiens_hsa050300.29501657
146Metabolic pathways_Homo sapiens_hsa011000.28838739
147beta-Alanine metabolism_Homo sapiens_hsa004100.26439403
148Peroxisome_Homo sapiens_hsa041460.23712976
149Linoleic acid metabolism_Homo sapiens_hsa005910.22729310
150cAMP signaling pathway_Homo sapiens_hsa040240.22421770
151Fatty acid metabolism_Homo sapiens_hsa012120.22263038
152Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049320.21578928

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