ARCHS4

Functional Annotation Prediction

Predicted biological processes (GO)

Rank	Gene Set	Z-score
1	glomerulus development (GO:0032835)	5.75470589
2	positive regulation of phosphoprotein phosphatase activity (GO:0032516)	5.40355651
3	epithelial cilium movement involved in determination of left/right asymmetry (GO:0060287)	5.34070993
4	motile cilium assembly (GO:0044458)	5.24641406
5	DNA deamination (GO:0045006)	4.54458753
6	epithelial to mesenchymal transition involved in endocardial cushion formation (GO:0003198)	4.52895385
7	negative regulation of mast cell activation (GO:0033004)	4.40532835
8	platelet dense granule organization (GO:0060155)	4.36136396
9	establishment of protein localization to mitochondrial membrane (GO:0090151)	4.29119618
10	axonemal dynein complex assembly (GO:0070286)	4.16244926
11	head development (GO:0060322)	4.15219771
12	eosinophil chemotaxis (GO:0048245)	4.09831466
13	positive regulation of cytosolic calcium ion concentration involved in phospholipase C-activating G-	4.07553625
14	ribosomal small subunit assembly (GO:0000028)	4.07300505
15	protein-cofactor linkage (GO:0018065)	4.06915789
16	ATP synthesis coupled proton transport (GO:0015986)	3.96322649
17	energy coupled proton transport, down electrochemical gradient (GO:0015985)	3.96322649
18	kidney mesenchyme development (GO:0072074)	3.96234184
19	mitochondrial ATP synthesis coupled proton transport (GO:0042776)	3.95950679
20	metallo-sulfur cluster assembly (GO:0031163)	3.90200132
21	iron-sulfur cluster assembly (GO:0016226)	3.90200132
22	retinal cone cell development (GO:0046549)	3.89279599
23	sulfation (GO:0051923)	3.86449028
24	cytidine metabolic process (GO:0046087)	3.76795980
25	cytidine catabolic process (GO:0006216)	3.76795980
26	cytidine deamination (GO:0009972)	3.76795980
27	positive regulation of T cell apoptotic process (GO:0070234)	3.74916419
28	regulation of single stranded viral RNA replication via double stranded DNA intermediate (GO:0045091	3.72959855
29	behavioral response to nicotine (GO:0035095)	3.72371790
30	establishment of tissue polarity (GO:0007164)	3.68323042
31	establishment of planar polarity (GO:0001736)	3.68323042
32	eosinophil migration (GO:0072677)	3.67693149
33	atrial cardiac muscle cell action potential (GO:0086014)	3.64669499
34	nephron epithelium morphogenesis (GO:0072088)	3.61534757
35	nephron tubule morphogenesis (GO:0072078)	3.61534757
36	mitochondrial electron transport, NADH to ubiquinone (GO:0006120)	3.59162510
37	cardiac epithelial to mesenchymal transition (GO:0060317)	3.58224523
38	L-fucose catabolic process (GO:0042355)	3.56827002
39	fucose catabolic process (GO:0019317)	3.56827002
40	L-fucose metabolic process (GO:0042354)	3.56827002
41	cellular response to electrical stimulus (GO:0071257)	3.56069597
42	positive regulation of inositol phosphate biosynthetic process (GO:0060732)	3.42599651
43	replicative senescence (GO:0090399)	3.41450592
44	pyrimidine ribonucleoside catabolic process (GO:0046133)	3.37859057
45	regulation of cellular respiration (GO:0043457)	3.37051593
46	respiratory electron transport chain (GO:0022904)	3.32087600
47	renal tubule morphogenesis (GO:0061333)	3.30959851
48	electron transport chain (GO:0022900)	3.29042309
49	regulation of activation of Janus kinase activity (GO:0010533)	3.25238612
50	mesenchymal cell development (GO:0014031)	3.25236682
51	cochlea development (GO:0090102)	3.23841780
52	protein complex biogenesis (GO:0070271)	3.21532836
53	GTP biosynthetic process (GO:0006183)	3.21327863
54	cardiac right ventricle morphogenesis (GO:0003215)	3.19153727
55	nonmotile primary cilium assembly (GO:0035058)	3.16791753
56	pattern specification involved in kidney development (GO:0061004)	3.16322495
57	regulation of sensory perception of pain (GO:0051930)	3.13248947
58	regulation of sensory perception (GO:0051931)	3.13248947
59	enteric nervous system development (GO:0048484)	3.12689869
60	epithelial cilium movement (GO:0003351)	3.11324102
61	mitochondrial respiratory chain complex I assembly (GO:0032981)	3.10640315
62	NADH dehydrogenase complex assembly (GO:0010257)	3.10640315
63	mitochondrial respiratory chain complex I biogenesis (GO:0097031)	3.10640315
64	G-protein coupled glutamate receptor signaling pathway (GO:0007216)	3.07882552
65	cardiac left ventricle morphogenesis (GO:0003214)	3.06820065
66	cilium movement (GO:0003341)	3.05366882
67	metanephric mesenchyme development (GO:0072075)	3.05057684
68	positive regulation of interleukin-8 secretion (GO:2000484)	3.04469590
69	spinal cord development (GO:0021510)	3.03159398
70	endoderm formation (GO:0001706)	2.99312520
71	rRNA catabolic process (GO:0016075)	2.92392649
72	mitochondrial respiratory chain complex assembly (GO:0033108)	2.92268373
73	DNA demethylation (GO:0080111)	2.92088025
74	sperm motility (GO:0030317)	2.91802449
75	positive regulation of lymphocyte apoptotic process (GO:0070230)	2.91345275
76	positive regulation of gastrulation (GO:2000543)	2.90960178
77	stem cell development (GO:0048864)	2.90691860
78	positive regulation of protein homodimerization activity (GO:0090073)	2.89040760
79	viral transcription (GO:0019083)	2.88520720
80	negative regulation of cytosolic calcium ion concentration (GO:0051481)	2.87031688
81	translational termination (GO:0006415)	2.78657201
82	regulation of chromatin binding (GO:0035561)	2.77229403
83	pyrimidine deoxyribonucleotide catabolic process (GO:0009223)	2.76884950
84	regulation of cilium movement (GO:0003352)	2.75226933
85	tRNA methylation (GO:0030488)	2.75129239
86	atrioventricular valve morphogenesis (GO:0003181)	2.74810807
87	regulation of transcription initiation from RNA polymerase II promoter (GO:0060260)	2.74386181
88	anterograde synaptic vesicle transport (GO:0048490)	2.74043014
89	dopamine transport (GO:0015872)	2.73189689
90	negative regulation of smooth muscle cell differentiation (GO:0051151)	2.71747840
91	cilium or flagellum-dependent cell motility (GO:0001539)	2.71624768
92	adaptation of signaling pathway (GO:0023058)	2.71546000
93	ubiquinone biosynthetic process (GO:0006744)	2.70550567
94	negative regulation of transcription regulatory region DNA binding (GO:2000678)	2.68424733
95	intracellular protein transmembrane import (GO:0044743)	2.67929339
96	positive regulation of uterine smooth muscle contraction (GO:0070474)	2.63575888
97	auditory receptor cell differentiation (GO:0042491)	2.62402269
98	positive regulation of histone H3-K4 methylation (GO:0051571)	2.62287652
99	negative regulation of T cell differentiation in thymus (GO:0033085)	2.61607734
100	UTP biosynthetic process (GO:0006228)	2.58664431

Predicted upstream transcription factors (ChEA)

Rank	Gene Set	Z-score
1	EZH2_22144423_ChIP-Seq_EOC_Human	6.46167609
2	FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse	5.15817661
3	VDR_22108803_ChIP-Seq_LS180_Human	2.69381056
4	EWS_26573619_Chip-Seq_HEK293_Human	2.65266202
5	EST1_17652178_ChIP-ChIP_JURKAT_Human	2.57789093
6	HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human	2.45406881
7	GABP_17652178_ChIP-ChIP_JURKAT_Human	2.25732896
8	AR_21572438_ChIP-Seq_LNCaP_Human	2.19795665
9	BMI1_23680149_ChIP-Seq_NPCS_Mouse	2.17347990
10	FUS_26573619_Chip-Seq_HEK293_Human	2.02787361
11	TAF15_26573619_Chip-Seq_HEK293_Human	2.01755156
12	EED_16625203_ChIP-ChIP_MESCs_Mouse	1.90865858
13	KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human	1.90402870
14	IGF1R_20145208_ChIP-Seq_DFB_Human	1.90151945
15	RNF2_27304074_Chip-Seq_NSC_Mouse	1.89167084
16	SUZ12_16625203_ChIP-ChIP_MESCs_Mouse	1.87427720
17	SUZ12_18555785_ChIP-Seq_MESCs_Mouse	1.84579644
18	CBX2_27304074_Chip-Seq_ESCs_Mouse	1.83884634
19	NR4A2_19515692_ChIP-ChIP_MN9D_Mouse	1.79738500
20	POU5F1_16153702_ChIP-ChIP_HESCs_Human	1.79729023
21	NOTCH1_17114293_ChIP-ChIP_T-ALL_Human	1.73892979
22	GBX2_23144817_ChIP-Seq_PC3_Human	1.71628167
23	EZH2_27304074_Chip-Seq_ESCs_Mouse	1.71298288
24	PPARD_23208498_ChIP-Seq_MDA-MB-231_Human	1.69648709
25	ELK1_19687146_ChIP-ChIP_HELA_Human	1.69477106
26	JARID2_20064375_ChIP-Seq_MESCs_Mouse	1.69196358
27	SUZ12_18692474_ChIP-Seq_MESCs_Mouse	1.68577065
28	SUZ12_27294783_Chip-Seq_ESCs_Mouse	1.67367475
29	CTBP1_25329375_ChIP-Seq_LNCAP_Human	1.66661673
30	TP63_19390658_ChIP-ChIP_HaCaT_Human	1.65375505
31	EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human	1.64832404
32	ETS1_20019798_ChIP-Seq_JURKAT_Human	1.64564536
33	ZFP57_27257070_Chip-Seq_ESCs_Mouse	1.57377905
34	ER_23166858_ChIP-Seq_MCF-7_Human	1.57325337
35	EZH2_27294783_Chip-Seq_ESCs_Mouse	1.55377415
36	TDRD3_21172665_ChIP-Seq_MCF-7_Human	1.51460867
37	BCAT_22108803_ChIP-Seq_LS180_Human	1.50164133
38	FOXA1_25329375_ChIP-Seq_VCAP_Human	1.46845608
39	FOXA1_27270436_Chip-Seq_PROSTATE_Human	1.46845608
40	FLI1_27457419_Chip-Seq_LIVER_Mouse	1.45930080
41	CEBPA_26348894_ChIP-Seq_LIVER_Mouse	1.44792743
42	RUNX1_26923725_Chip-Seq_MACROPHAGESS_Mouse	1.44498476
43	GLI1_17442700_ChIP-ChIP_MESCs_Mouse	1.42733391
44	TP53_22573176_ChIP-Seq_HFKS_Human	1.41701851
45	GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse	1.40926860
46	FOXP2_21765815_ChIP-ChIP_NEURO2A_Mouse	1.40691201
47	VDR_23849224_ChIP-Seq_CD4+_Human	1.39280327
48	IRF4_20064451_ChIP-Seq_CD4+T_Mouse	1.35583368
49	CBP_20019798_ChIP-Seq_JUKART_Human	1.35583368
50	STAT6_21828071_ChIP-Seq_BEAS2B_Human	1.35389819
51	RNF2_16625203_ChIP-ChIP_MESCs_Mouse	1.34594516
52	GRHL2_25758223_ChIP-Seq_PLACENTA_Mouse	1.33808554
53	THAP11_20581084_ChIP-Seq_MESCs_Mouse	1.31183912
54	JARID2_20075857_ChIP-Seq_MESCs_Mouse	1.30330879
55	HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse	1.28348731
56	E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse	1.25726794
57	YY1_21170310_ChIP-Seq_MESCs_Mouse	1.24357936
58	TP53_20018659_ChIP-ChIP_R1E_Mouse	1.24326656
59	PHC1_16625203_ChIP-ChIP_MESCs_Mouse	1.23727192
60	AUTS2_25519132_ChIP-Seq_293T-REX_Human	1.22286988
61	NANOG_20526341_ChIP-Seq_ESCs_Human	1.22073561
62	PRDM14_20953172_ChIP-Seq_ESCs_Human	1.20823038
63	NOTCH1_21737748_ChIP-Seq_TLL_Human	1.20365289
64	MYCN_21190229_ChIP-Seq_SHEP-21N_Human	1.19178990
65	RNF2_18974828_ChIP-Seq_MESCs_Mouse	1.18603951
66	EZH2_18974828_ChIP-Seq_MESCs_Mouse	1.18603951
67	AR_20517297_ChIP-Seq_VCAP_Human	1.17328462
68	TCF3/E2A_22897851_ChIP-Seq_JUKARTE6-1_Human	1.17194655
69	NCOR_22424771_ChIP-Seq_293T_Human	1.16588647
70	SUZ12_18974828_ChIP-Seq_MESCs_Mouse	1.16099870
71	UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human	1.14757452
72	ERA_21632823_ChIP-Seq_H3396_Human	1.13937058
73	RING1B_27294783_Chip-Seq_ESCs_Mouse	1.11939089
74	CTCF_20526341_ChIP-Seq_ESCs_Human	1.09011584
75	TOP2B_26459242_ChIP-Seq_MCF-7_Human	1.08487937
76	EBNA1_20929547_Chip-Seq_RAJI-cells_Human	1.05401574
77	MYC_18940864_ChIP-ChIP_HL60_Human	1.05213118
78	SUZ12_18692474_ChIP-Seq_MEFs_Mouse	1.04907731
79	NANOG_19829295_ChIP-Seq_ESCs_Human	1.03828759
80	SOX2_19829295_ChIP-Seq_ESCs_Human	1.03828759
81	PCGF2_27294783_Chip-Seq_ESCs_Mouse	1.03769645
82	P53_21459846_ChIP-Seq_SAOS-2_Human	1.03011387
83	SMAD2/3_21741376_ChIP-Seq_EPCs_Human	1.02605226
84	REST_21632747_ChIP-Seq_MESCs_Mouse	1.01216121
85	STAT1_20625510_ChIP-Seq_HELA_Human	1.00841255
86	JARID1A_20064375_ChIP-Seq_MESCs_Mouse	1.00398262
87	RNF2_27304074_Chip-Seq_ESCs_Mouse	0.98550931
88	KLF5_20875108_ChIP-Seq_MESCs_Mouse	0.97914226
89	CTBP2_25329375_ChIP-Seq_LNCAP_Human	0.97076148
90	ERG_20517297_ChIP-Seq_VCAP_Human	0.92705905
91	PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human	0.92614150
92	SMAD3_21741376_ChIP-Seq_ESCs_Human	0.92558273
93	FLI1_21867929_ChIP-Seq_TH2_Mouse	0.92462275
94	TCF4_23295773_ChIP-Seq_U87_Human	0.92049542
95	MTF2_20144788_ChIP-Seq_MESCs_Mouse	0.91630868
96	NFYA_21822215_ChIP-Seq_K562_Human	0.89946320
97	EBNA2_21746931_ChIP-Seq_IB4-LCL_Human	0.88742515
98	JUN_21703547_ChIP-Seq_K562_Human	0.88694415
99	HOXB7_26014856_ChIP-Seq_BT474_Human	0.88278421
100	GATA6_21074721_ChIP-Seq_CACO-2_Mouse	0.88239701

Predicted mouse phenotypes (MGI)

Rank	Gene Set	Z-score
1	MP0002653_abnormal_ependyma_morphology	3.66288523
2	MP0006292_abnormal_olfactory_placode	2.91341425
3	MP0003693_abnormal_embryo_hatching	2.90685433
4	MP0009379_abnormal_foot_pigmentation	2.72287288
5	MP0009384_cardiac_valve_regurgitation	2.66914890
6	MP0004885_abnormal_endolymph	2.53131954
7	MP0005671_abnormal_response_to	2.41856309
8	MP0001485_abnormal_pinna_reflex	2.40618752
9	MP0003119_abnormal_digestive_system	2.32726988
10	MP0000516_abnormal_urinary_system	2.22974595
11	MP0005367_renal/urinary_system_phenotyp	2.22974595
12	MP0004742_abnormal_vestibular_system	2.13175804
13	MP0002938_white_spotting	2.11592978
14	MP0002272_abnormal_nervous_system	2.01860401
15	MP0005377_hearing/vestibular/ear_phenot	1.98202148
16	MP0003878_abnormal_ear_physiology	1.98202148
17	MP0009046_muscle_twitch	1.90017831
18	MP0001486_abnormal_startle_reflex	1.82324236
19	MP0001502_abnormal_circadian_rhythm	1.81948089
20	MP0005551_abnormal_eye_electrophysiolog	1.69235078
21	MP0003283_abnormal_digestive_organ	1.63526562
22	MP0004145_abnormal_muscle_electrophysio	1.59517643
23	MP0003880_abnormal_central_pattern	1.57018563
24	MP0002736_abnormal_nociception_after	1.56861725
25	MP0003942_abnormal_urinary_system	1.55529005
26	MP0002733_abnormal_thermal_nociception	1.54135792
27	MP0003786_premature_aging	1.52444802
28	MP0001293_anophthalmia	1.51872458
29	MP0009745_abnormal_behavioral_response	1.51562781
30	MP0002160_abnormal_reproductive_system	1.47997909
31	MP0002638_abnormal_pupillary_reflex	1.45853537
32	MP0001968_abnormal_touch/_nociception	1.45759416
33	MP0000372_irregular_coat_pigmentation	1.45208765
34	MP0003646_muscle_fatigue	1.44409304
35	MP0003890_abnormal_embryonic-extraembry	1.43552134
36	MP0008995_early_reproductive_senescence	1.42814054
37	MP0005423_abnormal_somatic_nervous	1.37271159
38	MP0003938_abnormal_ear_development	1.33573061
39	MP0005187_abnormal_penis_morphology	1.32418126
40	MP0000049_abnormal_middle_ear	1.28124237
41	MP0001963_abnormal_hearing_physiology	1.25332781
42	MP0002234_abnormal_pharynx_morphology	1.22972847
43	MP0005195_abnormal_posterior_eye	1.20079240
44	MP0000026_abnormal_inner_ear	1.19635635
45	MP0004142_abnormal_muscle_tone	1.16546362
46	MP0005645_abnormal_hypothalamus_physiol	1.13548914
47	MP0005389_reproductive_system_phenotype	1.13066972
48	MP0005164_abnormal_response_to	1.13009429
49	MP0001970_abnormal_pain_threshold	1.12192191
50	MP0003763_abnormal_thymus_physiology	1.12141456
51	MP0002557_abnormal_social/conspecific_i	1.08983255
52	MP0004147_increased_porphyrin_level	1.08337707
53	MP0005646_abnormal_pituitary_gland	1.08025118
54	MP0003635_abnormal_synaptic_transmissio	1.04019560
55	MP0000230_abnormal_systemic_arterial	1.03576024
56	MP0005253_abnormal_eye_physiology	1.02759911
57	MP0000778_abnormal_nervous_system	1.02551416
58	MP0001986_abnormal_taste_sensitivity	1.02362203
59	MP0002063_abnormal_learning/memory/cond	1.02154861
60	MP0000631_abnormal_neuroendocrine_gland	1.01725348
61	MP0005387_immune_system_phenotype	1.01275203
62	MP0001790_abnormal_immune_system	1.01275203
63	MP0001119_abnormal_female_reproductive	0.97264477
64	MP0001800_abnormal_humoral_immune	0.94591724
65	MP0002572_abnormal_emotion/affect_behav	0.93090674
66	MP0005620_abnormal_muscle_contractility	0.92944726
67	MP0002098_abnormal_vibrissa_morphology	0.91921021
68	MP0000538_abnormal_urinary_bladder	0.90341171
69	MP0002277_abnormal_respiratory_mucosa	0.90145158
70	MP0008569_lethality_at_weaning	0.89213477
71	MP0005410_abnormal_fertilization	0.88962148
72	MP0006072_abnormal_retinal_apoptosis	0.87733885
73	MP0002127_abnormal_cardiovascular_syste	0.87094491
74	MP0001919_abnormal_reproductive_system	0.86818660
75	MP0002210_abnormal_sex_determination	0.85768285
76	MP0001984_abnormal_olfaction	0.85749224
77	MP0004924_abnormal_behavior	0.85372638
78	MP0005386_behavior/neurological_phenoty	0.85372638
79	MP0006054_spinal_hemorrhage	0.84768685
80	MP0002752_abnormal_somatic_nervous	0.84756214
81	MP0005391_vision/eye_phenotype	0.84255300
82	MP0001286_abnormal_eye_development	0.82582871
83	MP0000343_altered_response_to	0.82213696
84	MP0002064_seizures	0.81972736
85	MP0002734_abnormal_mechanical_nocicepti	0.81903531
86	MP0005623_abnormal_meninges_morphology	0.80960694
87	MP0004085_abnormal_heartbeat	0.80850091
88	MP0009643_abnormal_urine_homeostasis	0.80823378
89	MP0003252_abnormal_bile_duct	0.80466727
90	MP0002184_abnormal_innervation	0.78205254
91	MP0002735_abnormal_chemical_nociception	0.77364059
92	MP0003936_abnormal_reproductive_system	0.77218534
93	MP0009780_abnormal_chondrocyte_physiolo	0.76753901
94	MP0009053_abnormal_anal_canal	0.73714658
95	MP0002067_abnormal_sensory_capabilities	0.69722374
96	MP0005084_abnormal_gallbladder_morpholo	0.69411958
97	MP0000534_abnormal_ureter_morphology	0.68685101
98	MP0000653_abnormal_sex_gland	0.67896987
99	MP0000955_abnormal_spinal_cord	0.65856553
100	MP0008872_abnormal_physiological_respon	0.65316174

Predicted human phenotypes

Rank	Gene Set	Z-score
1	Dynein arm defect of respiratory motile cilia (HP:0012255)	7.16618733
2	Absent/shortened dynein arms (HP:0200106)	7.16618733
3	Respiratory insufficiency due to defective ciliary clearance (HP:0200073)	6.62949368
4	Chronic bronchitis (HP:0004469)	5.26807878
5	Abnormal ciliary motility (HP:0012262)	4.06420794
6	Abnormal respiratory motile cilium physiology (HP:0012261)	3.97393871
7	Absent rod-and cone-mediated responses on ERG (HP:0007688)	3.92403292
8	Abnormal respiratory epithelium morphology (HP:0012253)	3.81668820
9	Abnormal respiratory motile cilium morphology (HP:0005938)	3.81668820
10	Stomatitis (HP:0010280)	3.55509262
11	Acute necrotizing encephalopathy (HP:0006965)	3.46652882
12	Congenital stationary night blindness (HP:0007642)	3.24556285
13	Abnormal rod and cone electroretinograms (HP:0008323)	3.17514804
14	Rhinitis (HP:0012384)	3.15761938
15	Progressive macrocephaly (HP:0004481)	3.11049986
16	Reticulocytopenia (HP:0001896)	3.09952568
17	Abnormal mitochondria in muscle tissue (HP:0008316)	2.84610354
18	Pendular nystagmus (HP:0012043)	2.80034404
19	Mitochondrial inheritance (HP:0001427)	2.78982073
20	Acute encephalopathy (HP:0006846)	2.75698567
21	Elevated erythrocyte sedimentation rate (HP:0003565)	2.63722704
22	Nausea (HP:0002018)	2.62783398
23	Abnormality of the renal collecting system (HP:0004742)	2.61330318
24	Severe Myopia (HP:0011003)	2.60678399
25	Increased CSF lactate (HP:0002490)	2.56813386
26	Optic disc pallor (HP:0000543)	2.52732942
27	Bronchitis (HP:0012387)	2.50367781
28	Duplicated collecting system (HP:0000081)	2.45755887
29	Decreased central vision (HP:0007663)	2.41986699
30	Molar tooth sign on MRI (HP:0002419)	2.41487012
31	Abnormality of midbrain morphology (HP:0002418)	2.41487012
32	Hepatocellular necrosis (HP:0001404)	2.41099557
33	Nephronophthisis (HP:0000090)	2.41058868
34	Keratoconus (HP:0000563)	2.39876372
35	Increased corneal curvature (HP:0100692)	2.39876372
36	Inability to walk (HP:0002540)	2.37931493
37	Congenital, generalized hypertrichosis (HP:0004540)	2.29856520
38	Rib fusion (HP:0000902)	2.26218230
39	Hepatic necrosis (HP:0002605)	2.23608735
40	Constricted visual fields (HP:0001133)	2.18582090
41	Hemiplegia (HP:0002301)	2.18551957
42	Decreased circulating renin level (HP:0003351)	2.16469077
43	Increased hepatocellular lipid droplets (HP:0006565)	2.14614904
44	Abnormality of alanine metabolism (HP:0010916)	2.11899764
45	Hyperalaninemia (HP:0003348)	2.11899764
46	Abnormality of pyruvate family amino acid metabolism (HP:0010915)	2.11899764
47	Cerebral edema (HP:0002181)	2.09557892
48	Bronchiectasis (HP:0002110)	2.09543682
49	Nasal polyposis (HP:0100582)	2.08529645
50	Renal cortical cysts (HP:0000803)	2.06895837
51	Focal motor seizures (HP:0011153)	2.02556336
52	Absent thumb (HP:0009777)	2.02124903
53	Recurrent sinusitis (HP:0011108)	2.00678308
54	Anencephaly (HP:0002323)	1.99937153
55	Medial flaring of the eyebrow (HP:0010747)	1.96847614
56	Leukodystrophy (HP:0002415)	1.96488306
57	Abnormality of the renal medulla (HP:0100957)	1.95967557
58	Pancreatic fibrosis (HP:0100732)	1.94696034
59	Type II lissencephaly (HP:0007260)	1.92274459
60	Chromsome breakage (HP:0040012)	1.88221045
61	Birth length less than 3rd percentile (HP:0003561)	1.87725165
62	Abnormality of the pons (HP:0007361)	1.87326432
63	Shawl scrotum (HP:0000049)	1.85487666
64	Pancreatic cysts (HP:0001737)	1.83598725
65	Decreased activity of cytochrome C oxidase in muscle tissue (HP:0003688)	1.83503949
66	Microretrognathia (HP:0000308)	1.82780451
67	True hermaphroditism (HP:0010459)	1.82748168
68	Increased serum lactate (HP:0002151)	1.81154463
69	Abnormality of the renal cortex (HP:0011035)	1.79373073
70	Female pseudohermaphroditism (HP:0010458)	1.79002492
71	Hypoplasia of the pons (HP:0012110)	1.78316891
72	Methylmalonic acidemia (HP:0002912)	1.77194660
73	Genetic anticipation (HP:0003743)	1.76946463
74	Dysphonia (HP:0001618)	1.76448179
75	Chromosomal breakage induced by crosslinking agents (HP:0003221)	1.76356380
76	Abnormality of the fovea (HP:0000493)	1.74885066
77	Confusion (HP:0001289)	1.74651710
78	Lipid accumulation in hepatocytes (HP:0006561)	1.73886989
79	Abnormality of renal resorption (HP:0011038)	1.73360983
80	Congenital sensorineural hearing impairment (HP:0008527)	1.72517032
81	Renal Fanconi syndrome (HP:0001994)	1.71860739
82	Narrow forehead (HP:0000341)	1.70305945
83	Decreased electroretinogram (ERG) amplitude (HP:0000654)	1.68433481
84	Dysdiadochokinesis (HP:0002075)	1.66967822
85	Progressive cerebellar ataxia (HP:0002073)	1.66644989
86	Homocystinuria (HP:0002156)	1.64879129
87	Abnormality of homocysteine metabolism (HP:0010919)	1.64879129
88	Abnormality of serum amino acid levels (HP:0003112)	1.63676301
89	Pancytopenia (HP:0001876)	1.63146519
90	Bony spicule pigmentary retinopathy (HP:0007737)	1.62951676
91	Short hallux (HP:0010109)	1.62809407
92	Supernumerary spleens (HP:0009799)	1.62685239
93	Genu varum (HP:0002970)	1.60851680
94	Hypoplasia of the fovea (HP:0007750)	1.60568940
95	Aplasia/Hypoplasia of the fovea (HP:0008060)	1.60568940
96	Absent septum pellucidum (HP:0001331)	1.59603377
97	Delayed CNS myelination (HP:0002188)	1.59544043
98	Aplasia/Hypoplasia of the optic nerve (HP:0008058)	1.59236901
99	Adrenal hypoplasia (HP:0000835)	1.58449008
100	Long nose (HP:0003189)	1.57811208

Predicted kinase interactions (KEA)

Rank	Gene Set	Z-score
1	TXK	4.68703052
2	MUSK	4.07359627
3	VRK2	4.03364187
4	MAPK15	3.86534658
5	MST4	3.48227903
6	WNK4	3.14907291
7	TLK1	2.78004481
8	VRK1	2.75448720
9	TAF1	2.40461998
10	DYRK3	2.32034393
11	MAP4K1	2.29010936
12	PDK2	2.12887001
13	STK39	2.10081467
14	ADRBK2	2.07179415
15	TSSK6	2.05157783
16	NUAK1	1.78578197
17	PINK1	1.57059571
18	TIE1	1.56337127
19	GRK1	1.53023604
20	ZAK	1.51429743
21	WNK3	1.48514518
22	FRK	1.40827364
23	TNIK	1.39256469
24	CDC7	1.38582988
25	ADRBK1	1.36015566
26	PLK3	1.34391773
27	NME1	1.29218319
28	WNK1	1.29035642
29	OXSR1	1.22284885
30	CSK	1.20417236
31	BTK	1.17337817
32	MAPKAPK5	1.14083702
33	EIF2AK1	1.11274143
34	MAPKAPK3	1.09028312
35	KIT	0.96643931
36	PAK3	0.90240420
37	NEK2	0.85560405
38	DYRK2	0.85026557
39	KDR	0.80571297
40	MAP3K11	0.70299809
41	EIF2AK3	0.69610914
42	AURKA	0.67993226
43	ACVR1B	0.66882543
44	BMPR1B	0.63391232
45	IKBKE	0.62863056
46	IRAK2	0.62551539
47	ERBB3	0.62324832
48	ITK	0.60770589
49	IRAK4	0.60492678
50	PNCK	0.57047835
51	SYK	0.56998145
52	CAMK2A	0.56108770
53	CSNK1A1	0.55769495
54	TEC	0.55689598
55	AKT3	0.54978670
56	PRKG1	0.54948214
57	NEK1	0.54835455
58	BUB1	0.53784984
59	STK11	0.53698691
60	MAPK12	0.53089741
61	MAPK13	0.52540347
62	CAMK1	0.51975433
63	MKNK2	0.49802017
64	RPS6KA4	0.48786882
65	PRKCG	0.47574423
66	PASK	0.46939678
67	CSNK2A1	0.44641647
68	RPS6KA5	0.43748090
69	ZAP70	0.43631905
70	NME2	0.42756001
71	CSNK2A2	0.40288770
72	CASK	0.40113740
73	AURKB	0.39902792
74	PRKACA	0.39675190
75	TYRO3	0.39613419
76	HCK	0.39361706
77	EIF2AK2	0.39239684
78	LYN	0.39032471
79	CHEK2	0.38900214
80	PLK1	0.38793539
81	TGFBR1	0.37130805
82	MAP2K1	0.36529725
83	ABL2	0.36449770
84	PRKCA	0.35870539
85	MAP2K7	0.34973482
86	PRKCZ	0.32887362
87	NEK9	0.32525309
88	PRKCQ	0.30819748
89	LATS1	0.29900084
90	INSRR	0.29826104
91	PRKCE	0.29721480
92	AKT2	0.28712378
93	IRAK1	0.27196498
94	DDR2	0.27172226
95	SGK2	0.27106497
96	PRKCD	0.26963082
97	MAP3K12	0.26281101
98	GRK5	0.24493585
99	PRKD3	0.23012964
100	SGK223	0.22402643

Predicted pathways (KEGG)

Rank	Gene Set	Z-score
1	Oxidative phosphorylation_Homo sapiens_hsa00190	3.88425912
2	Parkinsons disease_Homo sapiens_hsa05012	3.62113676
3	Ribosome_Homo sapiens_hsa03010	3.60516205
4	Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa00533	3.27220026
5	Huntingtons disease_Homo sapiens_hsa05016	3.02919759
6	Sulfur relay system_Homo sapiens_hsa04122	2.70608533
7	Sulfur metabolism_Homo sapiens_hsa00920	2.69509266
8	Cardiac muscle contraction_Homo sapiens_hsa04260	2.65341689
9	Terpenoid backbone biosynthesis_Homo sapiens_hsa00900	2.58296355
10	Phototransduction_Homo sapiens_hsa04744	2.36198644
11	Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa00603	2.32093665
12	RNA polymerase_Homo sapiens_hsa03020	2.22968364
13	Basal transcription factors_Homo sapiens_hsa03022	2.22644010
14	Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa04932	2.21873432
15	Alzheimers disease_Homo sapiens_hsa05010	2.17656832
16	Proteasome_Homo sapiens_hsa03050	2.11635703
17	Ribosome biogenesis in eukaryotes_Homo sapiens_hsa03008	1.80667438
18	Primary immunodeficiency_Homo sapiens_hsa05340	1.67549645
19	Neuroactive ligand-receptor interaction_Homo sapiens_hsa04080	1.63383759
20	Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa00601	1.63069905
21	Homologous recombination_Homo sapiens_hsa03440	1.62752085
22	Folate biosynthesis_Homo sapiens_hsa00790	1.49830843
23	Peroxisome_Homo sapiens_hsa04146	1.45252866
24	Linoleic acid metabolism_Homo sapiens_hsa00591	1.33127098
25	Olfactory transduction_Homo sapiens_hsa04740	1.29925878
26	One carbon pool by folate_Homo sapiens_hsa00670	1.27765942
27	Taste transduction_Homo sapiens_hsa04742	1.17997385
28	RNA degradation_Homo sapiens_hsa03018	1.06686078
29	T cell receptor signaling pathway_Homo sapiens_hsa04660	1.02852213
30	Antigen processing and presentation_Homo sapiens_hsa04612	1.02468722
31	Basal cell carcinoma_Homo sapiens_hsa05217	1.01925618
32	Hematopoietic cell lineage_Homo sapiens_hsa04640	0.97279255
33	Cytosolic DNA-sensing pathway_Homo sapiens_hsa04623	0.95701143
34	Fanconi anemia pathway_Homo sapiens_hsa03460	0.95553100
35	alpha-Linolenic acid metabolism_Homo sapiens_hsa00592	0.95542018
36	Tryptophan metabolism_Homo sapiens_hsa00380	0.94769729
37	Purine metabolism_Homo sapiens_hsa00230	0.93292812
38	Nicotine addiction_Homo sapiens_hsa05033	0.91896316
39	Natural killer cell mediated cytotoxicity_Homo sapiens_hsa04650	0.90642310
40	Calcium signaling pathway_Homo sapiens_hsa04020	0.90177780
41	Glycine, serine and threonine metabolism_Homo sapiens_hsa00260	0.88016725
42	Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa00563	0.85146916
43	Dorso-ventral axis formation_Homo sapiens_hsa04320	0.82873696
44	Intestinal immune network for IgA production_Homo sapiens_hsa04672	0.82539784
45	Notch signaling pathway_Homo sapiens_hsa04330	0.78883712
46	Nitrogen metabolism_Homo sapiens_hsa00910	0.78202832
47	Cytokine-cytokine receptor interaction_Homo sapiens_hsa04060	0.76618857
48	Synthesis and degradation of ketone bodies_Homo sapiens_hsa00072	0.74094717
49	Systemic lupus erythematosus_Homo sapiens_hsa05322	0.71802432
50	Morphine addiction_Homo sapiens_hsa05032	0.71184051
51	Pyrimidine metabolism_Homo sapiens_hsa00240	0.67707455
52	Graft-versus-host disease_Homo sapiens_hsa05332	0.67452067
53	Steroid biosynthesis_Homo sapiens_hsa00100	0.63330695
54	Primary bile acid biosynthesis_Homo sapiens_hsa00120	0.63219103
55	Collecting duct acid secretion_Homo sapiens_hsa04966	0.62646006
56	Fat digestion and absorption_Homo sapiens_hsa04975	0.62518959
57	Cysteine and methionine metabolism_Homo sapiens_hsa00270	0.62139378
58	Wnt signaling pathway_Homo sapiens_hsa04310	0.62074133
59	ABC transporters_Homo sapiens_hsa02010	0.59126372
60	Caffeine metabolism_Homo sapiens_hsa00232	0.58907906
61	Renin secretion_Homo sapiens_hsa04924	0.58773643
62	Ether lipid metabolism_Homo sapiens_hsa00565	0.57829234
63	Taurine and hypotaurine metabolism_Homo sapiens_hsa00430	0.56090118
64	Glutamatergic synapse_Homo sapiens_hsa04724	0.54083662
65	Protein export_Homo sapiens_hsa03060	0.52707242
66	Propanoate metabolism_Homo sapiens_hsa00640	0.52485451
67	Glycerolipid metabolism_Homo sapiens_hsa00561	0.50606247
68	Mucin type O-Glycan biosynthesis_Homo sapiens_hsa00512	0.50047553
69	Salivary secretion_Homo sapiens_hsa04970	0.49171897
70	Selenocompound metabolism_Homo sapiens_hsa00450	0.48216500
71	cAMP signaling pathway_Homo sapiens_hsa04024	0.46352029
72	Cyanoamino acid metabolism_Homo sapiens_hsa00460	0.44680967
73	Metabolic pathways_Homo sapiens_hsa01100	0.44312017
74	Spliceosome_Homo sapiens_hsa03040	0.43514552
75	Vitamin digestion and absorption_Homo sapiens_hsa04977	0.41592139
76	Retrograde endocannabinoid signaling_Homo sapiens_hsa04723	0.41084572
77	Axon guidance_Homo sapiens_hsa04360	0.40514754
78	Melanoma_Homo sapiens_hsa05218	0.39592973
79	Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa04960	0.39124947
80	Chemical carcinogenesis_Homo sapiens_hsa05204	0.38735767
81	Insulin secretion_Homo sapiens_hsa04911	0.38636391
82	Asthma_Homo sapiens_hsa05310	0.38364474
83	Retinol metabolism_Homo sapiens_hsa00830	0.36484711
84	Maturity onset diabetes of the young_Homo sapiens_hsa04950	0.34443422
85	Porphyrin and chlorophyll metabolism_Homo sapiens_hsa00860	0.34436195
86	Long-term depression_Homo sapiens_hsa04730	0.34354230
87	cGMP-PKG signaling pathway_Homo sapiens_hsa04022	0.30455783
88	Drug metabolism - cytochrome P450_Homo sapiens_hsa00982	0.30033422
89	Nucleotide excision repair_Homo sapiens_hsa03420	0.29852591
90	Regulation of autophagy_Homo sapiens_hsa04140	0.28389599
91	GABAergic synapse_Homo sapiens_hsa04727	0.26978438
92	Serotonergic synapse_Homo sapiens_hsa04726	0.26245717
93	HTLV-I infection_Homo sapiens_hsa05166	0.25861037
94	ECM-receptor interaction_Homo sapiens_hsa04512	0.25227906
95	Protein digestion and absorption_Homo sapiens_hsa04974	0.24951336
96	Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa00980	0.24864499
97	Hedgehog signaling pathway_Homo sapiens_hsa04340	0.24072278
98	Mineral absorption_Homo sapiens_hsa04978	0.23435160
99	Long-term potentiation_Homo sapiens_hsa04720	0.22742384
100	Alcoholism_Homo sapiens_hsa05034	0.21839047

HNRNPDP1

Functional Annotation Prediction

Predicted biological processes (GO)

Predicted upstream transcription factors (ChEA)

Predicted mouse phenotypes (MGI)

Predicted human phenotypes

Predicted kinase interactions (KEA)

Predicted pathways (KEGG)

Most similar genes based on co-expression Upload to Enrichr

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