HNRNPF

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: This gene belongs to the subfamily of ubiquitously expressed heterogeneous nuclear ribonucleoproteins (hnRNPs). The hnRNPs are RNA binding proteins that complex with heterogeneous nuclear RNA (hnRNA). These proteins are associated with pre-mRNAs in the nucleus and regulate alternative splicing, polyadenylation, and other aspects of mRNA metabolism and transport. While all of the hnRNPs are present in the nucleus, some seem to shuttle between the nucleus and the cytoplasm. The hnRNP proteins have distinct nucleic acid binding properties. The protein encoded by this gene has three repeats of quasi-RRM domains that bind to RNAs which have guanosine-rich sequences. This protein is very similar to the family member hnRPH. Multiple alternatively spliced variants, encoding the same protein, have been identified. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1DNA unwinding involved in DNA replication (GO:0006268)5.18185238
2establishment of integrated proviral latency (GO:0075713)4.83960364
3DNA strand elongation involved in DNA replication (GO:0006271)4.75047803
4DNA replication initiation (GO:0006270)4.52691878
5DNA strand elongation (GO:0022616)4.52521837
6telomere maintenance via semi-conservative replication (GO:0032201)4.30074157
7protein localization to kinetochore (GO:0034501)4.17170512
8ribosomal small subunit assembly (GO:0000028)4.05508919
9nuclear pore organization (GO:0006999)4.05212199
10nuclear pore complex assembly (GO:0051292)3.96624845
11nucleobase biosynthetic process (GO:0046112)3.94562763
12telomere maintenance via recombination (GO:0000722)3.89721117
13formation of translation preinitiation complex (GO:0001731)3.85644842
14IMP biosynthetic process (GO:0006188)3.85333058
15mitotic nuclear envelope disassembly (GO:0007077)3.83666445
16establishment of viral latency (GO:0019043)3.82805777
17mitotic recombination (GO:0006312)3.80867990
18folic acid-containing compound biosynthetic process (GO:0009396)3.77838550
19maturation of SSU-rRNA (GO:0030490)3.75199771
20DNA replication checkpoint (GO:0000076)3.73093097
21regulation of translational fidelity (GO:0006450)3.67903167
22DNA replication-dependent nucleosome assembly (GO:0006335)3.62222408
23DNA replication-dependent nucleosome organization (GO:0034723)3.62222408
24protein localization to chromosome, centromeric region (GO:0071459)3.56428723
25purine nucleobase biosynthetic process (GO:0009113)3.55754177
26nuclear envelope disassembly (GO:0051081)3.54384096
27membrane disassembly (GO:0030397)3.54384096
28telomere maintenance via telomere lengthening (GO:0010833)3.48795619
29IMP metabolic process (GO:0046040)3.46930844
30mitotic metaphase plate congression (GO:0007080)3.46906544
31protein complex localization (GO:0031503)3.46039658
32mitotic chromosome condensation (GO:0007076)3.42591361
33DNA duplex unwinding (GO:0032508)3.41578611
34DNA geometric change (GO:0032392)3.39724185
35nucleotide-excision repair, DNA gap filling (GO:0006297)3.35513245
36viral transcription (GO:0019083)3.34503681
37CENP-A containing nucleosome assembly (GO:0034080)3.33948659
38chromatin remodeling at centromere (GO:0031055)3.32475062
39translational termination (GO:0006415)3.32361721
40regulation of transcription involved in G1/S transition of mitotic cell cycle (GO:0000083)3.31113791
41DNA replication-independent nucleosome assembly (GO:0006336)3.27283211
42DNA replication-independent nucleosome organization (GO:0034724)3.27283211
43cellular protein complex localization (GO:0034629)3.25227082
44translesion synthesis (GO:0019985)3.20029496
45regulation of single stranded viral RNA replication via double stranded DNA intermediate (GO:00450913.19745362
46metaphase plate congression (GO:0051310)3.19571629
47regulation of spindle organization (GO:0090224)3.18844134
48regulation of translational termination (GO:0006449)3.17241031
49proline biosynthetic process (GO:0006561)3.17140722
50pore complex assembly (GO:0046931)3.15305342
51ribosome assembly (GO:0042255)3.14000061
52negative regulation of mRNA metabolic process (GO:1903312)3.13986087
53nucleobase-containing small molecule interconversion (GO:0015949)3.12184258
54double-strand break repair via nonhomologous end joining (GO:0006303)3.11370105
55non-recombinational repair (GO:0000726)3.11370105
56translational elongation (GO:0006414)3.10167850
57attachment of spindle microtubules to kinetochore (GO:0008608)3.09084845
58ribosome biogenesis (GO:0042254)3.07717356
59kinetochore organization (GO:0051383)3.06113437
60translational initiation (GO:0006413)3.04538304
61negative regulation of mRNA splicing, via spliceosome (GO:0048025)3.03629816
62spliceosomal tri-snRNP complex assembly (GO:0000244)3.03569312
63DNA ligation (GO:0006266)2.99469579
64somatic hypermutation of immunoglobulin genes (GO:0016446)2.98963991
65somatic diversification of immune receptors via somatic mutation (GO:0002566)2.98963991
66Golgi transport vesicle coating (GO:0048200)2.98564438
67COPI coating of Golgi vesicle (GO:0048205)2.98564438
68nuclear-transcribed mRNA catabolic process, nonsense-mediated decay (GO:0000184)2.98135385
69negative regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051436)2.97725744
70ribonucleoprotein complex biogenesis (GO:0022613)2.97247463
71establishment of chromosome localization (GO:0051303)2.97120910
72tRNA aminoacylation for protein translation (GO:0006418)2.96695901
73mitotic sister chromatid cohesion (GO:0007064)2.96143328
74heterochromatin organization (GO:0070828)2.95542303
75ribosomal large subunit biogenesis (GO:0042273)2.94372427
76chromosome condensation (GO:0030261)2.93570429
77sister chromatid segregation (GO:0000819)2.93324066
78postreplication repair (GO:0006301)2.91721584
79DNA deamination (GO:0045006)2.91624537
80telomere maintenance (GO:0000723)2.91525351
81anaphase-promoting complex-dependent proteasomal ubiquitin-dependent protein catabolic process (GO:02.91171366
82negative regulation of RNA splicing (GO:0033119)2.90584160
83telomere organization (GO:0032200)2.90581565
84mitotic sister chromatid segregation (GO:0000070)2.90077342
85regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051439)2.89703466
86proteasome assembly (GO:0043248)2.89647406
87amino acid activation (GO:0043038)2.89325408
88tRNA aminoacylation (GO:0043039)2.89325408
89dosage compensation (GO:0007549)2.89040675
90ribosomal small subunit biogenesis (GO:0042274)2.88649372
91regulation of attachment of spindle microtubules to kinetochore (GO:0051988)2.88549227
92regulation of histone H3-K9 methylation (GO:0051570)2.86614978
93DNA conformation change (GO:0071103)2.85464166
94chromatin assembly or disassembly (GO:0006333)2.83161834
95histone exchange (GO:0043486)2.82531237
96negative regulation of ubiquitin-protein transferase activity (GO:0051444)2.82307645
97negative regulation of ligase activity (GO:0051352)2.82307645
98SRP-dependent cotranslational protein targeting to membrane (GO:0006614)2.82287862
99negative regulation of mitotic sister chromatid separation (GO:2000816)2.81480447
100negative regulation of sister chromatid segregation (GO:0033046)2.81480447
101negative regulation of mitotic metaphase/anaphase transition (GO:0045841)2.81480447
102negative regulation of metaphase/anaphase transition of cell cycle (GO:1902100)2.81480447
103negative regulation of mitotic sister chromatid segregation (GO:0033048)2.81480447
104nuclear envelope organization (GO:0006998)2.78181452
105regulation of RNA export from nucleus (GO:0046831)2.77378364
106DNA topological change (GO:0006265)2.76555177
107peptidyl-arginine omega-N-methylation (GO:0035247)2.76311920
108L-serine metabolic process (GO:0006563)2.75978272
109chromosome segregation (GO:0007059)2.75536925
110positive regulation of chromosome segregation (GO:0051984)2.75378825
111termination of RNA polymerase II transcription (GO:0006369)2.75356150
112rRNA processing (GO:0006364)2.75243270
113mitotic spindle checkpoint (GO:0071174)2.74910277
114viral mRNA export from host cell nucleus (GO:0046784)2.74090030
115protein targeting to ER (GO:0045047)2.72512543
116cotranslational protein targeting to membrane (GO:0006613)2.72302365
117mismatch repair (GO:0006298)2.71756715
118protein localization to chromosome (GO:0034502)2.70818218
119rRNA metabolic process (GO:0016072)2.66619852
120* RNA splicing, via transesterification reactions with bulged adenosine as nucleophile (GO:0000377)2.65734940
121* mRNA splicing, via spliceosome (GO:0000398)2.65734940
122ATP-dependent chromatin remodeling (GO:0043044)2.65544750
123* RNA splicing, via transesterification reactions (GO:0000375)2.65406749
124regulation of mitotic spindle organization (GO:0060236)2.64670469
125meiotic chromosome segregation (GO:0045132)2.63714998
126negative regulation of histone methylation (GO:0031061)2.63278209
127regulation of centrosome cycle (GO:0046605)2.62786893
128regulation of chromosome segregation (GO:0051983)2.62654306
129base-excision repair (GO:0006284)2.62296491
130viral life cycle (GO:0019058)2.61170579
131negative regulation of mRNA processing (GO:0050686)2.60704907
132spliceosomal snRNP assembly (GO:0000387)2.58854788
133establishment of protein localization to endoplasmic reticulum (GO:0072599)2.58390090
134G1/S transition of mitotic cell cycle (GO:0000082)2.57408210
135cell cycle G1/S phase transition (GO:0044843)2.57408210
136nuclear-transcribed mRNA catabolic process (GO:0000956)2.57233826
137cellular protein complex disassembly (GO:0043624)2.56904651
138negative regulation of chromosome segregation (GO:0051985)2.55057451

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1E2F7_22180533_ChIP-Seq_HELA_Human9.32478708
2FOXM1_23109430_ChIP-Seq_U2OS_Human4.01585506
3MYC_18555785_ChIP-Seq_MESCs_Mouse3.77912727
4E2F4_17652178_ChIP-ChIP_JURKAT_Human3.55211632
5EKLF_21900194_ChIP-Seq_ERYTHROCYTE_Mouse3.48932966
6* FOXM1_25889361_ChIP-Seq_OE33_AND_U2OS_Human2.96045102
7EGR1_19374776_ChIP-ChIP_THP-1_Human2.75456215
8MYC_19079543_ChIP-ChIP_MESCs_Mouse2.63973792
9MYC_19030024_ChIP-ChIP_MESCs_Mouse2.47109582
10MYC_18358816_ChIP-ChIP_MESCs_Mouse2.37018858
11EST1_17652178_ChIP-ChIP_JURKAT_Human2.32482302
12KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human2.22501173
13* MYC_22102868_ChIP-Seq_BL_Human2.20518196
14NELFA_20434984_ChIP-Seq_ESCs_Mouse2.18927927
15AR_21909140_ChIP-Seq_LNCAP_Human2.17674450
16GABP_17652178_ChIP-ChIP_JURKAT_Human2.15880519
17ETS1_20019798_ChIP-Seq_JURKAT_Human2.11420518
18XRN2_22483619_ChIP-Seq_HELA_Human2.07423906
19CREB1_15753290_ChIP-ChIP_HEK293T_Human2.05361020
20E2F1_21310950_ChIP-Seq_MCF-7_Human2.03310809
21JARID1A_20064375_ChIP-Seq_MESCs_Mouse1.99761053
22ELF1_17652178_ChIP-ChIP_JURKAT_Human1.97994022
23MYBL1_21750041_ChIP-ChIP_SPERMATOCYTES_Mouse1.95683652
24VDR_23849224_ChIP-Seq_CD4+_Human1.95602583
25* SPI1_22790984_ChIP-Seq_ERYTHROLEUKEMIA_Mouse1.89637930
26HCFC1_20581084_ChIP-Seq_MESCs_Mouse1.82486725
27CHD1_19587682_ChIP-ChIP_MESCs_Mouse1.80234098
28FOXP3_21729870_ChIP-Seq_TREG_Human1.77638793
29TAL1_20887958_ChIP-Seq_HPC-7_Mouse1.75480264
30MYBL2_22936984_ChIP-ChIP_MESCs_Mouse1.72610772
31KDM5B_21448134_ChIP-Seq_MESCs_Mouse1.70131080
32CIITA_25753668_ChIP-Seq_RAJI_Human1.67894624
33E2F1_18555785_ChIP-Seq_MESCs_Mouse1.67470331
34MYCN_18555785_ChIP-Seq_MESCs_Mouse1.67148342
35ASXL1_24218140_ChIP-Seq_BMDM_Mouse1.65511762
36DCP1A_22483619_ChIP-Seq_HELA_Human1.63530221
37PPARG_23326641_ChIP-Seq_C3H10T1-2_Mouse1.60420171
38ZNF263_19887448_ChIP-Seq_K562_Human1.58501332
39* GABP_19822575_ChIP-Seq_HepG2_Human1.56573940
40TTF2_22483619_ChIP-Seq_HELA_Human1.52572945
41POU5F1_18555785_ChIP-Seq_MESCs_Mouse1.52463240
42NOTCH1_17114293_ChIP-ChIP_T-ALL_Human1.50690210
43SOX9_22984422_ChIP-ChIP_TESTIS_Rat1.49007016
44HOXB4_20404135_ChIP-ChIP_EML_Mouse1.48750591
45ZFX_18555785_ChIP-Seq_MESCs_Mouse1.48697177
46ELK1_19687146_ChIP-ChIP_HELA_Human1.47221594
47NANOG_18555785_ChIP-Seq_MESCs_Mouse1.44160545
48SPI1_22096565_ChIP-ChIP_GC-B_Mouse1.42060025
49FOXO3_22982991_ChIP-Seq_MACROPHAGES_Mouse1.41237675
50* SFPI1_20887958_ChIP-Seq_HPC-7_Mouse1.39824305
51* VDR_21846776_ChIP-Seq_THP-1_Human1.39425863
52* KDM5A_27292631_Chip-Seq_BREAST_Human1.35665766
53ERG_20887958_ChIP-Seq_HPC-7_Mouse1.34568820
54YY1_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse1.30278987
55* FLI1_20887958_ChIP-Seq_HPC-7_Mouse1.28771205
56NUCKS1_24931609_ChIP-Seq_HEPATOCYTES_Mouse1.28202796
57PRDM5_23873026_ChIP-Seq_MEFs_Mouse1.25050302
58E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse1.22932581
59THAP11_20581084_ChIP-Seq_MESCs_Mouse1.21879814
60TFEB_21752829_ChIP-Seq_HELA_Human1.21765890
61CCND1_20090754_ChIP-ChIP_RETINA_Mouse1.21023008
62HSF1_23293686_ChIP-Seq_STHDH_STRIATAL_Mouse1.20076861
63* SPI1_23547873_ChIP-Seq_NB4_Human1.20052786
64IRF8_22096565_ChIP-ChIP_GC-B_Mouse1.19170035
65STAT3_1855785_ChIP-Seq_MESCs_Mouse1.18728331
66KLF4_18555785_ChIP-Seq_MESCs_Mouse1.16615720
67HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human1.14676846
68NOTCH1_21737748_ChIP-Seq_TLL_Human1.13887453
69POU5F1_18700969_ChIP-ChIP_MESCs_Mouse1.11578869
70* E2F4_21247883_ChIP-Seq_LYMPHOBLASTOID_Human1.10261483
71ZFP42_18358816_ChIP-ChIP_MESCs_Mouse1.09371026
72PDX1_19855005_ChIP-ChIP_MIN6_Mouse1.08754053
73* MECOM_23826213_ChIP-Seq_KASUMI_Mouse1.08041845
74MYB_26560356_Chip-Seq_TH2_Human1.07793537
75CHD1_26751641_Chip-Seq_LNCaP_Human1.07301922
76TP63_19390658_ChIP-ChIP_HaCaT_Human1.06197054
77MYB_21317192_ChIP-Seq_ERMYB_Mouse1.06193355
78PADI4_21655091_ChIP-ChIP_MCF-7_Human1.06172486
79ESR1_15608294_ChIP-ChIP_MCF-7_Human1.05859818
80SMAD1_18555785_ChIP-Seq_MESCs_Mouse1.05721183
81BCL3_23251550_ChIP-Seq_MUSCLE_Mouse1.03896356
82ZFP281_18358816_ChIP-ChIP_MESCs_Mouse1.03883700
83IRF8_22096565_ChIP-ChIP_GC-B_Human1.02590158
84MYB_26560356_Chip-Seq_TH1_Human1.02405345
85* GFI1B_20887958_ChIP-Seq_HPC-7_Mouse1.01691971
86* MAF_26560356_Chip-Seq_TH1_Human1.01435862
87SCL_19346495_ChIP-Seq_HPC-7_Human1.00710292
88DACH1_20351289_ChIP-Seq_MDA-MB-231_Human1.00163575
89CEBPB_23403033_ChIP-Seq_LIVER_Mouse1.00071683
90SMAD4_19686287_ChIP-ChIP_HaCaT_Human0.98662504
91SRF_21415370_ChIP-Seq_HL-1_Mouse0.98436352
92YY1_21170310_ChIP-Seq_MESCs_Mouse0.98187272
93CIITA_18437201_ChIP-ChIP_Raji_B_and_iDC_Human0.98098183
94* UTX_26944678_Chip-Seq_JUKART_Human0.97985828
95CLOCK_20551151_ChIP-Seq_293T_Human0.96466495
96TCFAP2C_20176728_ChIP-ChIP_TROPHOBLAST_STEM_CELLS_Mouse0.95971565
97CREB1_23762244_ChIP-Seq_HIPPOCAMPUS_Rat0.95868239
98CEBPA_23403033_ChIP-Seq_LIVER_Mouse0.94669131
99TBP_23326641_ChIP-Seq_C3H10T1-2_Mouse0.93989389
100KLF6_26769127_Chip-Seq_PDAC-Cell_line_Human0.93278296
101RBPJ_22232070_ChIP-Seq_NCS_Mouse0.92849370
102MYCN_21190229_ChIP-Seq_SHEP-21N_Human0.92346214
103NR1H3_23393188_ChIP-Seq_ATHEROSCLEROTIC-FOAM_Human0.92065770
104* CREM_20920259_ChIP-Seq_GC1-SPG_Mouse0.91571662
105CNOT3_19339689_ChIP-ChIP_MESCs_Mouse0.91112732
106TRP63_18441228_ChIP-ChIP_KERATINOCYTES_Mouse0.90555225
107RUNX1_22412390_ChIP-Seq_EML_Mouse0.88825467
108SOX2_18555785_ChIP-Seq_MESCs_Mouse0.88725115
109SOX17_20123909_ChIP-Seq_XEN_Mouse0.88317089
110PPARG_19300518_ChIP-PET_3T3-L1_Mouse0.87899522
111DMRT1_21621532_ChIP-ChIP_FETAL_Ovary0.87473838
112STAT4_19710469_ChIP-ChIP_TH1__Mouse0.87024021
113CUX1_19635798_ChIP-ChIP_MULTIPLE_HUMAN_CANCER_TYPES_Human0.85164967
114FOXP3_17237761_ChIP-ChIP_TREG_Mouse0.84646695
115POU5F1_18358816_ChIP-ChIP_MESCs_Mouse0.84202503
116KLF4_19030024_ChIP-ChIP_MESCs_Mouse0.83761515
117SMARCA4_20176728_ChIP-ChIP_TSCs_Mouse0.83512310
118KLF4_18358816_ChIP-ChIP_MESCs_Mouse0.83475517
119* CREB1_20920259_ChIP-Seq_GC1-SPG_Mouse0.82905758
120BRD4_27068464_Chip-Seq_AML-cells_Mouse0.82475416
121RUNX1_20887958_ChIP-Seq_HPC-7_Mouse0.81859687
122HNF4A_19761587_ChIP-ChIP_CACO-2_Human0.81735478

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0003693_abnormal_embryo_hatching4.28456388
2MP0010094_abnormal_chromosome_stability4.02503554
3MP0004957_abnormal_blastocyst_morpholog3.56016399
4MP0003111_abnormal_nucleus_morphology3.55268779
5MP0008057_abnormal_DNA_replication3.47945729
6MP0003077_abnormal_cell_cycle3.36942480
7MP0002396_abnormal_hematopoietic_system2.98211930
8MP0008058_abnormal_DNA_repair2.70868312
9MP0010352_gastrointestinal_tract_polyps2.70627592
10MP0008007_abnormal_cellular_replicative2.58611811
11MP0003941_abnormal_skin_development2.16788978
12MP0001730_embryonic_growth_arrest2.06410495
13MP0010307_abnormal_tumor_latency2.04944496
14MP0004808_abnormal_hematopoietic_stem2.01526677
15MP0000350_abnormal_cell_proliferation1.99133818
16MP0002796_impaired_skin_barrier1.97591009
17MP0003763_abnormal_thymus_physiology1.95621894
18MP0008932_abnormal_embryonic_tissue1.92448119
19MP0000490_abnormal_crypts_of1.87305859
20MP0006054_spinal_hemorrhage1.80559804
21MP0005397_hematopoietic_system_phenotyp1.65246237
22MP0001545_abnormal_hematopoietic_system1.65246237
23MP0005451_abnormal_body_composition1.63815398
24MP0005501_abnormal_skin_physiology1.60524249
25MP0003123_paternal_imprinting1.59996251
26MP0009333_abnormal_splenocyte_physiolog1.59453135
27MP0002398_abnormal_bone_marrow1.57448075
28MP0004185_abnormal_adipocyte_glucose1.56637509
29MP0008877_abnormal_DNA_methylation1.55879203
30MP0002019_abnormal_tumor_incidence1.52952928
31MP0003786_premature_aging1.50917061
32MP0001697_abnormal_embryo_size1.49547483
33MP0001672_abnormal_embryogenesis/_devel1.48810711
34MP0005380_embryogenesis_phenotype1.48810711
35MP0001835_abnormal_antigen_presentation1.48415315
36MP0005076_abnormal_cell_differentiation1.47873832
37MP0000703_abnormal_thymus_morphology1.44083520
38MP0002080_prenatal_lethality1.41061134
39MP0002722_abnormal_immune_system1.40717774
40MP0003984_embryonic_growth_retardation1.40299935
41MP0002088_abnormal_embryonic_growth/wei1.37149503
42MP0000689_abnormal_spleen_morphology1.37006354
43MP0002086_abnormal_extraembryonic_tissu1.34820407
44MP0009697_abnormal_copulation1.34641908
45MP0002009_preneoplasia1.34330047
46MP0000685_abnormal_immune_system1.32942322
47MP0000313_abnormal_cell_death1.32049182
48MP0004197_abnormal_fetal_growth/weight/1.30826390
49MP0002166_altered_tumor_susceptibility1.29670852
50MP0009278_abnormal_bone_marrow1.28647874
51MP0004233_abnormal_muscle_weight1.28363615
52MP0003567_abnormal_fetal_cardiomyocyte1.24231601
53MP0002085_abnormal_embryonic_tissue1.23871706
54MP0002084_abnormal_developmental_patter1.22047501
55MP0001800_abnormal_humoral_immune1.21076111
56MP0002429_abnormal_blood_cell1.20491270
57MP0005671_abnormal_response_to1.20109143
58MP0008260_abnormal_autophagy1.18430777
59MP0000716_abnormal_immune_system1.16451997
60MP0003705_abnormal_hypodermis_morpholog1.13690829
61MP0006035_abnormal_mitochondrial_morpho1.12310498
62MP0002006_tumorigenesis1.10748166
63MP0002420_abnormal_adaptive_immunity1.10391948
64MP0002452_abnormal_antigen_presenting1.09573964
65MP0001819_abnormal_immune_cell1.08481841
66MP0003566_abnormal_cell_adhesion1.07591897
67MP0003453_abnormal_keratinocyte_physiol1.07526947
68MP0005023_abnormal_wound_healing1.07328785
69MP0000858_altered_metastatic_potential1.05460963
70MP0001293_anophthalmia1.04683453
71MP0001853_heart_inflammation1.04506111
72MP0003315_abnormal_perineum_morphology1.03285431
73MP0002405_respiratory_system_inflammati1.02396256
74MP0003221_abnormal_cardiomyocyte_apopto1.02391602
75MP0000465_gastrointestinal_hemorrhage1.00748148
76MP0010155_abnormal_intestine_physiology0.98727106
77MP0001881_abnormal_mammary_gland0.97321170
78MP0002723_abnormal_immune_serum0.96122590
79MP0003806_abnormal_nucleotide_metabolis0.94778693
80MP0001873_stomach_inflammation0.94527562
81MP0001216_abnormal_epidermal_layer0.93277965
82MP0001727_abnormal_embryo_implantation0.90513139
83MP0001346_abnormal_lacrimal_gland0.89848295
84MP0001915_intracranial_hemorrhage0.88988949
85MP0000627_abnormal_mammary_gland0.87933562
86MP0002210_abnormal_sex_determination0.87852145
87MP0002060_abnormal_skin_morphology0.86125891
88MP0002254_reproductive_system_inflammat0.85653025
89MP0003436_decreased_susceptibility_to0.85072362
90MP0004782_abnormal_surfactant_physiolog0.84836788
91MP0009785_altered_susceptibility_to0.84672360
92MP0000477_abnormal_intestine_morphology0.83244097
93MP0005408_hypopigmentation0.82839607
94MP0005025_abnormal_response_to0.82438153
95MP0005000_abnormal_immune_tolerance0.81628684
96MP0003186_abnormal_redox_activity0.80502406
97MP0001145_abnormal_male_reproductive0.80087759
98MP0000537_abnormal_urethra_morphology0.79387290
99MP0001661_extended_life_span0.77340926
100MP0003121_genomic_imprinting0.76492955
101MP0009703_decreased_birth_body0.76408852
102MP0010030_abnormal_orbit_morphology0.74805041
103MP0004947_skin_inflammation0.73885380
104MP0005464_abnormal_platelet_physiology0.73161963
105MP0005621_abnormal_cell_physiology0.72305017
106MP0003943_abnormal_hepatobiliary_system0.72226257
107MP0000678_abnormal_parathyroid_gland0.72009153
108MP0003300_gastrointestinal_ulcer0.71328835
109MP0009053_abnormal_anal_canal0.71162629
110MP0003448_altered_tumor_morphology0.70463097
111MP0003890_abnormal_embryonic-extraembry0.70405519
112MP0005384_cellular_phenotype0.70282926
113MP0002098_abnormal_vibrissa_morphology0.70171813
114MP0000358_abnormal_cell_content/0.70093672
115MP0006036_abnormal_mitochondrial_physio0.70092815
116MP0001849_ear_inflammation0.69950746
117MP0002132_abnormal_respiratory_system0.69793945
118MP0004264_abnormal_extraembryonic_tissu0.69248762
119MP0002092_abnormal_eye_morphology0.69018591
120MP0000377_abnormal_hair_follicle0.68619703
121MP0001790_abnormal_immune_system0.68356222
122MP0005387_immune_system_phenotype0.68356222
123MP0001929_abnormal_gametogenesis0.67401555
124MP0002697_abnormal_eye_size0.66843440
125MP0009672_abnormal_birth_weight0.66671614
126MP0002877_abnormal_melanocyte_morpholog0.66441699
127MP0010234_abnormal_vibrissa_follicle0.64271450
128MP0002095_abnormal_skin_pigmentation0.64204219
129MP0000653_abnormal_sex_gland0.64192080
130MP0003718_maternal_effect0.63891331
131MP0002111_abnormal_tail_morphology0.62892939
132MP0009931_abnormal_skin_appearance0.62342269
133MP0003699_abnormal_female_reproductive0.57249081
134MP0000467_abnormal_esophagus_morphology0.56722425

Predicted human phenotypes

RankGene SetZ-score
1Reticulocytopenia (HP:0001896)3.90035445
2Birth length less than 3rd percentile (HP:0003561)3.81524811
3Abnormality of cells of the erythroid lineage (HP:0012130)3.49722242
4Microvesicular hepatic steatosis (HP:0001414)3.44020947
5Colon cancer (HP:0003003)3.38707488
6Abnormal number of erythroid precursors (HP:0012131)3.35850391
7Progressive muscle weakness (HP:0003323)3.21802789
8Selective tooth agenesis (HP:0001592)3.18670743
9Thrombocytosis (HP:0001894)3.17639822
10Oral leukoplakia (HP:0002745)3.06585932
11Chromsome breakage (HP:0040012)3.01011995
12Progressive external ophthalmoplegia (HP:0000590)2.99340444
13Ependymoma (HP:0002888)2.93178846
14Medulloblastoma (HP:0002885)2.92664091
15Agnosia (HP:0010524)2.91862964
16Aplastic anemia (HP:0001915)2.90154916
17IgM deficiency (HP:0002850)2.85946914
18Abnormality of the anterior horn cell (HP:0006802)2.83338025
19Degeneration of anterior horn cells (HP:0002398)2.83338025
20Abnormality of glycolysis (HP:0004366)2.78803642
2111 pairs of ribs (HP:0000878)2.78787181
22Abnormality of chromosome stability (HP:0003220)2.74243394
23Chromosomal breakage induced by crosslinking agents (HP:0003221)2.68564781
24Myelodysplasia (HP:0002863)2.68507187
25Basal cell carcinoma (HP:0002671)2.63622458
26Aplasia/Hypoplasia of the sacrum (HP:0008517)2.62307218
27Breast hypoplasia (HP:0003187)2.60100782
28Abnormal gallbladder physiology (HP:0012438)2.54573804
29Cholecystitis (HP:0001082)2.54573804
30Nephroblastoma (Wilms tumor) (HP:0002667)2.53058122
31Amaurosis fugax (HP:0100576)2.49530499
32Increased serum pyruvate (HP:0003542)2.47216679
33Neoplasm of the pancreas (HP:0002894)2.43546369
34Patellar aplasia (HP:0006443)2.43211457
35Proximal placement of thumb (HP:0009623)2.43145948
36Abnormality of the preputium (HP:0100587)2.41626160
37Deviation of the thumb (HP:0009603)2.40769846
38Lymphoma (HP:0002665)2.36360691
39Meckel diverticulum (HP:0002245)2.35350748
40Rhabdomyosarcoma (HP:0002859)2.30579516
41Embryonal renal neoplasm (HP:0011794)2.29664829
42Abnormality of the umbilical cord (HP:0010881)2.29229974
43Absent thumb (HP:0009777)2.27518559
44Aplasia/Hypoplasia of the patella (HP:0006498)2.26478121
45Abnormality of the ileum (HP:0001549)2.23088608
46Increased nuchal translucency (HP:0010880)2.23024754
47Abnormality of T cells (HP:0002843)2.21199939
48Septate vagina (HP:0001153)2.20825748
49Pallor (HP:0000980)2.19927041
50Recurrent bronchitis (HP:0002837)2.18624228
51Rough bone trabeculation (HP:0100670)2.18277241
52Short 4th metacarpal (HP:0010044)2.17036326
53Aplasia/Hypoplasia of the 4th metacarpal (HP:0010042)2.17036326
54Premature ovarian failure (HP:0008209)2.16973460
55Recurrent viral infections (HP:0004429)2.16177528
56Ragged-red muscle fibers (HP:0003200)2.15572583
57T lymphocytopenia (HP:0005403)2.15076079
58Aplasia/Hypoplasia of the uvula (HP:0010293)2.13927102
59Bone marrow hypocellularity (HP:0005528)2.13610212
60Microretrognathia (HP:0000308)2.12866205
61Macrocytic anemia (HP:0001972)2.12396218
62Abnormal umbilical cord blood vessels (HP:0011403)2.11327304
63Single umbilical artery (HP:0001195)2.11327304
64Abnormality of the fetal cardiovascular system (HP:0010948)2.11327304
65Cortical dysplasia (HP:0002539)2.11056990
66Duodenal stenosis (HP:0100867)2.09113913
67Small intestinal stenosis (HP:0012848)2.09113913
68Spastic diplegia (HP:0001264)2.08075506
69Overlapping toe (HP:0001845)2.07405178
70Premature graying of hair (HP:0002216)2.06909974
71Multiple enchondromatosis (HP:0005701)2.06095279
72Abnormality of T cell physiology (HP:0011840)2.06015217
73High pitched voice (HP:0001620)2.05258188
74Missing ribs (HP:0000921)2.04324303
75Squamous cell carcinoma (HP:0002860)2.03176231
76Ectopic kidney (HP:0000086)2.02494400
77Abnormality of methionine metabolism (HP:0010901)2.01755775
78Prominent nose (HP:0000448)2.01686748
79Microglossia (HP:0000171)2.01084197
80Acute myeloid leukemia (HP:0004808)2.01004481
81Carpal bone hypoplasia (HP:0001498)2.00979228
82Chronic otitis media (HP:0000389)1.98867006
83Abnormality of T cell number (HP:0011839)1.98240707
84Ankyloglossia (HP:0010296)1.97861276
85Cellular immunodeficiency (HP:0005374)1.97340296
86Deep philtrum (HP:0002002)1.96488842
87Abnormality of the calcaneus (HP:0008364)1.96420793
88Horseshoe kidney (HP:0000085)1.95801828
89Abnormal number of incisors (HP:0011064)1.94870847
90Volvulus (HP:0002580)1.93736896
91Atresia of the external auditory canal (HP:0000413)1.93412859
92Sloping forehead (HP:0000340)1.92766358
93Cutaneous melanoma (HP:0012056)1.92462736
94Impulsivity (HP:0100710)1.91243218
95Abnormal trabecular bone morphology (HP:0100671)1.90780048
96Choanal atresia (HP:0000453)1.90477397
97Biliary tract neoplasm (HP:0100574)1.89938208
98Sparse eyelashes (HP:0000653)1.89291302
99Trismus (HP:0000211)1.88532921
100Abnormalities of placenta or umbilical cord (HP:0001194)1.86987233
101IgG deficiency (HP:0004315)1.86809657
102Poikiloderma (HP:0001029)1.86060262
103IgA deficiency (HP:0002720)1.85978310
104Secondary amenorrhea (HP:0000869)1.85974284
105Hyperacusis (HP:0010780)1.84606110
106Neoplasm of the colon (HP:0100273)1.84475607
107Facial cleft (HP:0002006)1.84318275
108Tracheoesophageal fistula (HP:0002575)1.82999700
109B lymphocytopenia (HP:0010976)1.81755036
110Abnormality of B cell number (HP:0010975)1.81755036
111Pancytopenia (HP:0001876)1.80335237
112Cafe-au-lait spot (HP:0000957)1.78323979
113Abnormality of oral frenula (HP:0000190)1.78114447
114Abnormality of the fingertips (HP:0001211)1.78044444
115Abnormality of reticulocytes (HP:0004312)1.77873692
116Entropion (HP:0000621)1.77836780
117Reduced antithrombin III activity (HP:0001976)1.77697713
118Slender long bone (HP:0003100)1.77125060
119Abnormality of the salivary glands (HP:0010286)1.76920142
120Shoulder girdle muscle weakness (HP:0003547)1.75698581
121Glossoptosis (HP:0000162)1.75312609
122Absent radius (HP:0003974)1.74909432
123Asymmetry of the thorax (HP:0001555)1.74297855
124Petechiae (HP:0000967)1.73087714
125Abnormality of the carotid arteries (HP:0005344)1.72675547
126Progressive hearing impairment (HP:0001730)1.72469105
127Pili torti (HP:0003777)1.72072786
128Abnormality of cells of the lymphoid lineage (HP:0012140)1.71684126
129Optic nerve coloboma (HP:0000588)1.71226056
130Aplasia involving forearm bones (HP:0009822)1.71171818
131Absent forearm bone (HP:0003953)1.71171818
132Neoplasm of the oral cavity (HP:0100649)1.69854593
133Abnormality of the duodenum (HP:0002246)1.69842606
134Abnormality of DNA repair (HP:0003254)1.69498254
135Abnormal lung lobation (HP:0002101)1.69336765
136Abnormality of homocysteine metabolism (HP:0010919)1.68563621
137Homocystinuria (HP:0002156)1.68563621
138Gout (HP:0001997)1.68414754
139Sparse lateral eyebrow (HP:0005338)1.68397749
140Cleft eyelid (HP:0000625)1.68195692
141Insidious onset (HP:0003587)1.68028415
142Termporal pattern (HP:0011008)1.68028415
143Ankle contracture (HP:0006466)1.68026642
144Ovarian neoplasm (HP:0100615)1.67430771
145Abnormality of the astrocytes (HP:0100707)1.66995355
146Astrocytoma (HP:0009592)1.66995355
147Combined immunodeficiency (HP:0005387)1.66315264
148Malignant gastrointestinal tract tumors (HP:0006749)1.65631413
149Gastrointestinal carcinoma (HP:0002672)1.65631413
150Megaloblastic anemia (HP:0001889)1.64970847
151Elevated erythrocyte sedimentation rate (HP:0003565)1.64172121
152Abnormality of pyrimidine metabolism (HP:0004353)1.64146300
153Bicuspid aortic valve (HP:0001647)1.64106781
154Neoplasm of striated muscle (HP:0009728)1.63896135
155Lymphopenia (HP:0001888)1.63887051
156Micronodular cirrhosis (HP:0001413)1.59968819
157Orthostatic hypotension (HP:0001278)1.59093018
158Aplasia/Hypoplasia involving the carpal bones (HP:0006502)1.58470678

Predicted kinase interactions (KEA)

RankGene SetZ-score
1CDC73.90200038
2WEE13.67473249
3SMG13.33971402
4BUB13.29403572
5PBK2.89848044
6VRK22.69732306
7EEF2K2.64978453
8NEK22.58319956
9ACVR1B2.27419210
10TSSK62.26484253
11EIF2AK12.22679975
12MAP4K12.09209992
13PASK2.03495726
14RPS6KB21.97212684
15STK101.92498794
16BRSK21.79624232
17TTK1.77117654
18PKN21.75747308
19SRPK11.75664672
20TGFBR11.74570487
21TAF11.73150804
22RPS6KA41.72603429
23MAP3K101.71938195
24NME21.70232537
25NEK11.69505673
26CDK121.66297663
27ATR1.63394585
28FLT31.62219859
29TESK21.60542628
30MKNK11.54478192
31SCYL21.53889673
32CDK71.50165881
33CDK41.47532163
34PLK11.47328653
35AURKB1.47107034
36EIF2AK31.44694542
37DYRK31.41925647
38MAP3K81.40973045
39PLK41.30374147
40LRRK21.29263902
41PRPF4B1.25843883
42IRAK31.24966607
43PAK41.18955157
44VRK11.16998193
45BTK1.10492802
46MST1R1.10102383
47NME11.09229855
48STK41.08785660
49JAK31.08383480
50CHEK11.06936316
51MAP2K31.06650014
52PIM11.06330119
53PLK31.05835758
54ZAP701.04916648
55CCNB11.04849576
56STK161.00420988
57KDR0.99846956
58CHEK20.97583569
59BRD40.96721047
60EPHA20.93391592
61CDK60.92728673
62FGFR40.88532301
63EIF2AK20.87937097
64ICK0.85158766
65BRSK10.84901716
66TEC0.84739069
67MKNK20.84700323
68TRIB30.82496625
69PIM20.81828672
70MAPKAPK30.81446704
71ATM0.79681089
72TLK10.79330506
73TYK20.78669282
74KIT0.75181260
75TESK10.74535284
76CSF1R0.73049730
77PDK20.72213851
78CLK10.71568175
79MST40.71094094
80TXK0.70747713
81AURKA0.70601806
82CDK20.70147679
83ITK0.67130499
84STK30.66892220
85ALK0.65496973
86MAP3K30.65336858
87GRK60.63288856
88MAP3K140.62235742
89MELK0.57589365
90CDK90.57528391
91TAOK20.56981193
92CDK80.56892641
93ERBB40.56044616
94CSNK2A20.55384481
95DAPK10.54965827
96BRAF0.50406700
97TTN0.49355038
98CSNK2A10.47500765
99RAF10.47156185
100NLK0.47154126
101NEK90.47054982
102PAK20.46906226
103LATS20.46213971
104CDK10.45619371
105MTOR0.45008429
106PAK10.44916528
107LCK0.44851912
108CHUK0.44750313
109ERN10.44183838
110STK240.43995427
111TRIM280.43562325
112PTK60.41825212
113ARAF0.41685422
114AKT20.41459147
115PRKCI0.40570341
116KSR20.38710807
117ZAK0.38272209
118MARK30.36718497
119RPS6KA50.36703034
120IKBKB0.36346064
121MAPK110.35694315
122BMX0.34841304
123YES10.34080006
124BLK0.34048549
125LYN0.33724762
126ILK0.33245531
127FGFR10.33182434
128TBK10.33151992
129MAP3K110.33061797
130MAPKAPK20.30674175
131SIK10.30213565
132PRKDC0.26522355
133NEK60.26482963

Predicted pathways (KEGG)

RankGene SetZ-score
1DNA replication_Homo sapiens_hsa030304.98625697
2Mismatch repair_Homo sapiens_hsa034304.07262866
3Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030083.11957583
4Spliceosome_Homo sapiens_hsa030403.05468015
5Base excision repair_Homo sapiens_hsa034103.02246812
6RNA transport_Homo sapiens_hsa030132.79221460
7Ribosome_Homo sapiens_hsa030102.68770937
8Cell cycle_Homo sapiens_hsa041102.66604828
9Nucleotide excision repair_Homo sapiens_hsa034202.66165217
10Homologous recombination_Homo sapiens_hsa034402.64086981
11One carbon pool by folate_Homo sapiens_hsa006702.60088894
12Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa009702.31438121
13Proteasome_Homo sapiens_hsa030502.31198698
14RNA polymerase_Homo sapiens_hsa030202.24893509
15Non-homologous end-joining_Homo sapiens_hsa034502.12464461
16Pyrimidine metabolism_Homo sapiens_hsa002402.04463183
17Fanconi anemia pathway_Homo sapiens_hsa034601.91132221
18RNA degradation_Homo sapiens_hsa030181.72043636
19Antigen processing and presentation_Homo sapiens_hsa046121.64698341
20p53 signaling pathway_Homo sapiens_hsa041151.64013015
21mRNA surveillance pathway_Homo sapiens_hsa030151.56303974
22Basal transcription factors_Homo sapiens_hsa030221.49494190
23Primary immunodeficiency_Homo sapiens_hsa053401.42367073
24Herpes simplex infection_Homo sapiens_hsa051681.29618337
25Epstein-Barr virus infection_Homo sapiens_hsa051691.23923213
26Pyruvate metabolism_Homo sapiens_hsa006201.20533065
27Viral carcinogenesis_Homo sapiens_hsa052031.16676286
28Cytosolic DNA-sensing pathway_Homo sapiens_hsa046231.11329806
29Systemic lupus erythematosus_Homo sapiens_hsa053221.09549456
30Selenocompound metabolism_Homo sapiens_hsa004501.03601291
31Vitamin B6 metabolism_Homo sapiens_hsa007501.03349339
32Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006301.01749522
33Butirosin and neomycin biosynthesis_Homo sapiens_hsa005240.97494716
34HTLV-I infection_Homo sapiens_hsa051660.97036206
35Purine metabolism_Homo sapiens_hsa002300.96206659
36Legionellosis_Homo sapiens_hsa051340.96089479
37Pentose phosphate pathway_Homo sapiens_hsa000300.94506905
38Measles_Homo sapiens_hsa051620.93694758
39Small cell lung cancer_Homo sapiens_hsa052220.93190602
40Pathogenic Escherichia coli infection_Homo sapiens_hsa051300.92240138
41Fructose and mannose metabolism_Homo sapiens_hsa000510.90900955
42NF-kappa B signaling pathway_Homo sapiens_hsa040640.87630471
43Thyroid cancer_Homo sapiens_hsa052160.86931058
44Transcriptional misregulation in cancer_Homo sapiens_hsa052020.79772186
45Ubiquitin mediated proteolysis_Homo sapiens_hsa041200.78760161
46Terpenoid backbone biosynthesis_Homo sapiens_hsa009000.76988926
47Biosynthesis of amino acids_Homo sapiens_hsa012300.75011608
48MicroRNAs in cancer_Homo sapiens_hsa052060.74339486
49Apoptosis_Homo sapiens_hsa042100.73393975
50Drug metabolism - other enzymes_Homo sapiens_hsa009830.73255595
51Steroid biosynthesis_Homo sapiens_hsa001000.70193508
52Cyanoamino acid metabolism_Homo sapiens_hsa004600.70113415
53Chronic myeloid leukemia_Homo sapiens_hsa052200.69814952
54Shigellosis_Homo sapiens_hsa051310.69115132
55Progesterone-mediated oocyte maturation_Homo sapiens_hsa049140.68704437
56Hematopoietic cell lineage_Homo sapiens_hsa046400.67616142
57Galactose metabolism_Homo sapiens_hsa000520.67109140
58Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004000.66735711
59Hepatitis B_Homo sapiens_hsa051610.66490315
60Cysteine and methionine metabolism_Homo sapiens_hsa002700.65610964
61Fatty acid elongation_Homo sapiens_hsa000620.64607045
62Protein processing in endoplasmic reticulum_Homo sapiens_hsa041410.63614100
63Viral myocarditis_Homo sapiens_hsa054160.63223412
64Leishmaniasis_Homo sapiens_hsa051400.63156291
65Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa005200.62050949
66Glycine, serine and threonine metabolism_Homo sapiens_hsa002600.61526316
67Folate biosynthesis_Homo sapiens_hsa007900.61126597
68B cell receptor signaling pathway_Homo sapiens_hsa046620.59461473
69N-Glycan biosynthesis_Homo sapiens_hsa005100.59346893
70Bacterial invasion of epithelial cells_Homo sapiens_hsa051000.57895228
71Intestinal immune network for IgA production_Homo sapiens_hsa046720.57240132
72Oocyte meiosis_Homo sapiens_hsa041140.56838398
73Colorectal cancer_Homo sapiens_hsa052100.56731562
74Influenza A_Homo sapiens_hsa051640.56701036
75Leukocyte transendothelial migration_Homo sapiens_hsa046700.52974886
76Acute myeloid leukemia_Homo sapiens_hsa052210.52900298
77Notch signaling pathway_Homo sapiens_hsa043300.52027423
78NOD-like receptor signaling pathway_Homo sapiens_hsa046210.50562290
79T cell receptor signaling pathway_Homo sapiens_hsa046600.49652007
80RIG-I-like receptor signaling pathway_Homo sapiens_hsa046220.47945380
81Toxoplasmosis_Homo sapiens_hsa051450.45936526
82Inflammatory bowel disease (IBD)_Homo sapiens_hsa053210.45141070
83Sulfur relay system_Homo sapiens_hsa041220.45105943
84Jak-STAT signaling pathway_Homo sapiens_hsa046300.43334684
85Adherens junction_Homo sapiens_hsa045200.41893912
86Huntingtons disease_Homo sapiens_hsa050160.40484682
87Pancreatic cancer_Homo sapiens_hsa052120.39599858
88Natural killer cell mediated cytotoxicity_Homo sapiens_hsa046500.39479807
89Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002500.38621185
90Protein export_Homo sapiens_hsa030600.38562408
91TGF-beta signaling pathway_Homo sapiens_hsa043500.38225039
92Carbon metabolism_Homo sapiens_hsa012000.37246759
93Vitamin digestion and absorption_Homo sapiens_hsa049770.35330838
94Central carbon metabolism in cancer_Homo sapiens_hsa052300.34740900
95Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008600.34229898
96Pathways in cancer_Homo sapiens_hsa052000.33731540
97HIF-1 signaling pathway_Homo sapiens_hsa040660.33576398
98Glutathione metabolism_Homo sapiens_hsa004800.32743191
99Endometrial cancer_Homo sapiens_hsa052130.32389217
100Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa045500.32116801
101Fc gamma R-mediated phagocytosis_Homo sapiens_hsa046660.30723864
102Bladder cancer_Homo sapiens_hsa052190.30588388
103Propanoate metabolism_Homo sapiens_hsa006400.29937566
104Fc epsilon RI signaling pathway_Homo sapiens_hsa046640.29232343
105Hippo signaling pathway_Homo sapiens_hsa043900.29103070
106Prostate cancer_Homo sapiens_hsa052150.28197946
107Glycolysis / Gluconeogenesis_Homo sapiens_hsa000100.27702300
108Allograft rejection_Homo sapiens_hsa053300.27674009
109Fatty acid metabolism_Homo sapiens_hsa012120.27170857
110Osteoclast differentiation_Homo sapiens_hsa043800.26849587
111Non-small cell lung cancer_Homo sapiens_hsa052230.26583016
112Metabolic pathways_Homo sapiens_hsa011000.25800515
113Renin-angiotensin system_Homo sapiens_hsa046140.25646040
114Citrate cycle (TCA cycle)_Homo sapiens_hsa000200.25354142
115Arginine biosynthesis_Homo sapiens_hsa002200.25168505
116Basal cell carcinoma_Homo sapiens_hsa052170.23920122
1172-Oxocarboxylic acid metabolism_Homo sapiens_hsa012100.22536268
118Lysine degradation_Homo sapiens_hsa003100.22407131
119Pantothenate and CoA biosynthesis_Homo sapiens_hsa007700.21580111
120Hepatitis C_Homo sapiens_hsa051600.21097328
121Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010400.20534491
122Phenylalanine metabolism_Homo sapiens_hsa003600.19927146
123Arginine and proline metabolism_Homo sapiens_hsa003300.17071271

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