ARCHS4

Functional Annotation Prediction

Predicted biological processes (GO)

Rank	Gene Set	Z-score
1	regulation of DNA endoreduplication (GO:0032875)	7.16777636
2	male meiosis I (GO:0007141)	6.59239454
3	synapsis (GO:0007129)	6.23442092
4	DNA methylation involved in gamete generation (GO:0043046)	6.09349025
5	piRNA metabolic process (GO:0034587)	6.03080961
6	histone H3-K36 demethylation (GO:0070544)	5.75675588
7	male meiosis (GO:0007140)	5.73332505
8	negative regulation of gene silencing (GO:0060969)	5.45931803
9	meiosis I (GO:0007127)	5.39862374
10	chromosome organization involved in meiosis (GO:0070192)	5.37711926
11	response to pheromone (GO:0019236)	5.22912030
12	positive regulation of protein ubiquitination involved in ubiquitin-dependent protein catabolic proc	5.01586757
13	regulation of transcription from RNA polymerase I promoter (GO:0006356)	4.94442045
14	regulation of histone H3-K9 methylation (GO:0051570)	4.88853116
15	regulation of meiosis I (GO:0060631)	4.78847708
16	meiotic nuclear division (GO:0007126)	4.78643676
17	meiotic chromosome segregation (GO:0045132)	4.76998299
18	sister chromatid cohesion (GO:0007062)	4.69910115
19	acrosome reaction (GO:0007340)	4.56643878
20	histone H3-K9 demethylation (GO:0033169)	4.46617634
21	microtubule depolymerization (GO:0007019)	4.44857505
22	growth hormone receptor signaling pathway (GO:0060396)	4.42069921
23	synaptonemal complex assembly (GO:0007130)	4.39352047
24	DNA packaging (GO:0006323)	4.27393685
25	sperm motility (GO:0030317)	4.26221646
26	chromosome condensation (GO:0030261)	4.25330068
27	positive regulation of mitochondrial fission (GO:0090141)	4.05569017
28	negative regulation of DNA-dependent DNA replication (GO:2000104)	4.04214807
29	synaptonemal complex organization (GO:0070193)	4.02601763
30	protein polyglutamylation (GO:0018095)	4.01955737
31	resolution of meiotic recombination intermediates (GO:0000712)	4.00082039
32	spermatid development (GO:0007286)	3.92549120
33	cellular response to growth hormone stimulus (GO:0071378)	3.85006826
34	meiotic cell cycle process (GO:1903046)	3.82226217
35	binding of sperm to zona pellucida (GO:0007339)	3.56437382
36	regulation of centriole replication (GO:0046599)	3.56074081
37	regulation of skeletal muscle contraction (GO:0014819)	3.50972602
38	signal complex assembly (GO:0007172)	3.47558851
39	sperm-egg recognition (GO:0035036)	3.42294530
40	cerebral cortex neuron differentiation (GO:0021895)	3.39959765
41	regulation of protein ubiquitination involved in ubiquitin-dependent protein catabolic process (GO:2	3.35296251
42	spermatid nucleus differentiation (GO:0007289)	3.32881369
43	male gamete generation (GO:0048232)	3.31917670
44	spermatogenesis (GO:0007283)	3.31751319
45	sulfation (GO:0051923)	3.31088261
46	fusion of sperm to egg plasma membrane (GO:0007342)	3.29955906
47	sex differentiation (GO:0007548)	3.28101920
48	head development (GO:0060322)	3.23948451
49	regulation of chromatin silencing (GO:0031935)	3.23475871
50	genitalia morphogenesis (GO:0035112)	3.23361931
51	negative regulation of inclusion body assembly (GO:0090084)	3.20790691
52	gamete generation (GO:0007276)	3.19568992
53	microtubule polymerization or depolymerization (GO:0031109)	3.18164539
54	response to gravity (GO:0009629)	3.16921704
55	positive regulation of meiosis (GO:0045836)	3.15227767
56	positive regulation of mitotic sister chromatid separation (GO:1901970)	3.10797129
57	positive regulation of mitotic metaphase/anaphase transition (GO:0045842)	3.10797129
58	positive regulation of metaphase/anaphase transition of cell cycle (GO:1902101)	3.10797129
59	protein refolding (GO:0042026)	3.09718676
60	negative regulation of Rho protein signal transduction (GO:0035024)	3.06528951
61	muscle atrophy (GO:0014889)	2.99906179
62	positive regulation of meiotic cell cycle (GO:0051446)	2.98402047
63	DNA damage response, signal transduction by p53 class mediator resulting in transcription of p21 cla	2.95820434
64	regulation of NFAT protein import into nucleus (GO:0051532)	2.93452277
65	striatum development (GO:0021756)	2.92947279
66	histone H4-K12 acetylation (GO:0043983)	2.91332315
67	single strand break repair (GO:0000012)	2.89225680
68	germ cell development (GO:0007281)	2.86080978
69	regulation of Arp2/3 complex-mediated actin nucleation (GO:0034315)	2.85442210
70	limb development (GO:0060173)	2.84414173
71	appendage development (GO:0048736)	2.84414173
72	gene silencing by RNA (GO:0031047)	2.84186747
73	retrograde transport, vesicle recycling within Golgi (GO:0000301)	2.81546170
74	regulation of transcription involved in cell fate commitment (GO:0060850)	2.80933535
75	DNA damage response, signal transduction resulting in transcription (GO:0042772)	2.79596675
76	cell proliferation in forebrain (GO:0021846)	2.76982748
77	fat-soluble vitamin catabolic process (GO:0042363)	2.73508470
78	vitamin catabolic process (GO:0009111)	2.73508470
79	embryonic forelimb morphogenesis (GO:0035115)	2.72074213
80	meiotic cell cycle (GO:0051321)	2.71797502
81	embryonic body morphogenesis (GO:0010172)	2.71305903
82	coronary vasculature morphogenesis (GO:0060977)	2.68457737
83	positive regulation of response to oxidative stress (GO:1902884)	2.66123696
84	positive regulation of cellular response to oxidative stress (GO:1900409)	2.66123696
85	protein targeting to Golgi (GO:0000042)	2.64377696
86	microtubule nucleation (GO:0007020)	2.64146177
87	response to muscle activity (GO:0014850)	2.63596940
88	mismatch repair (GO:0006298)	2.62624758
89	reciprocal DNA recombination (GO:0035825)	2.62241791
90	reciprocal meiotic recombination (GO:0007131)	2.62241791
91	regulation of mitochondrial fission (GO:0090140)	2.60586306
92	cilium or flagellum-dependent cell motility (GO:0001539)	2.59888445
93	cellular ketone body metabolic process (GO:0046950)	2.59746125
94	histone H4-K5 acetylation (GO:0043981)	2.59737330
95	histone H4-K8 acetylation (GO:0043982)	2.59737330
96	peptidyl-threonine dephosphorylation (GO:0035970)	2.58026144
97	nuclear-transcribed mRNA poly(A) tail shortening (GO:0000289)	2.56720570
98	cell-cell recognition (GO:0009988)	2.55967236
99	establishment of nucleus localization (GO:0040023)	2.54324414
100	positive regulation of protein homodimerization activity (GO:0090073)	2.53948239

Predicted upstream transcription factors (ChEA)

Rank	Gene Set	Z-score
1	FUS_26573619_Chip-Seq_HEK293_Human	3.57762739
2	TAF15_26573619_Chip-Seq_HEK293_Human	3.53026616
3	VDR_22108803_ChIP-Seq_LS180_Human	3.45408909
4	STAT6_21828071_ChIP-Seq_BEAS2B_Human	2.89364655
5	RBPJ_22232070_ChIP-Seq_NCS_Mouse	2.70596284
6	ZNF274_21170338_ChIP-Seq_K562_Hela	2.67151455
7	SALL1_21062744_ChIP-ChIP_HESCs_Human	2.37938383
8	MYBL1_21750041_ChIP-ChIP_SPERMATOCYTES_Mouse	2.34840906
9	IGF1R_20145208_ChIP-Seq_DFB_Human	2.32017999
10	EWS_26573619_Chip-Seq_HEK293_Human	2.28757052
11	EZH2_22144423_ChIP-Seq_EOC_Human	2.26882772
12	CTBP2_25329375_ChIP-Seq_LNCAP_Human	2.20001071
13	CTBP1_25329375_ChIP-Seq_LNCAP_Human	2.15519242
14	ER_23166858_ChIP-Seq_MCF-7_Human	2.11729484
15	RNF2_27304074_Chip-Seq_NSC_Mouse	2.10509558
16	EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human	1.95935024
17	IRF4_20064451_ChIP-Seq_CD4+T_Mouse	1.95224958
18	CBP_20019798_ChIP-Seq_JUKART_Human	1.95224958
19	CBX2_27304074_Chip-Seq_ESCs_Mouse	1.94418890
20	BMI1_23680149_ChIP-Seq_NPCS_Mouse	1.90650104
21	POU3F2_20337985_ChIP-ChIP_501MEL_Human	1.88272217
22	GLI1_17442700_ChIP-ChIP_MESCs_Mouse	1.88125482
23	CEBPD_23245923_ChIP-Seq_MEFs_Mouse	1.83872446
24	GBX2_23144817_ChIP-Seq_PC3_Human	1.82962793
25	ZFP57_27257070_Chip-Seq_ESCs_Mouse	1.82942858
26	RNF2_16625203_ChIP-ChIP_MESCs_Mouse	1.82264936
27	UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human	1.80941099
28	P300_19829295_ChIP-Seq_ESCs_Human	1.77618059
29	GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse	1.75286718
30	TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse	1.69283138
31	STAT3_23295773_ChIP-Seq_U87_Human	1.57766328
32	EED_16625203_ChIP-ChIP_MESCs_Mouse	1.56950277
33	SMAD_19615063_ChIP-ChIP_OVARY_Human	1.56022366
34	MYCN_21190229_ChIP-Seq_SHEP-21N_Human	1.55101934
35	PHC1_16625203_ChIP-ChIP_MESCs_Mouse	1.53884295
36	POU5F1_18555785_ChIP-Seq_MESCs_Mouse	1.49525690
37	SMAD4_21799915_ChIP-Seq_A2780_Human	1.46268005
38	KDM5B_21448134_ChIP-Seq_MESCs_Mouse	1.45189629
39	POU5F1_26923725_Chip-Seq_MESODERM_Mouse	1.45115240
40	TEAD4_26923725_Chip-Seq_HEMANGIOBLAST_Mouse	1.45115240
41	AUTS2_25519132_ChIP-Seq_293T-REX_Human	1.42968409
42	SMARCD1_25818293_ChIP-Seq_ESCs_Mouse	1.39041672
43	AR_25329375_ChIP-Seq_VCAP_Human	1.37281989
44	PKCTHETA_26484144_Chip-Seq_BREAST_Human	1.37272353
45	TP63_19390658_ChIP-ChIP_HaCaT_Human	1.35983442
46	PCGF2_27294783_Chip-Seq_NPCs_Mouse	1.35735587
47	TDRD3_21172665_ChIP-Seq_MCF-7_Human	1.34887199
48	EZH2_27304074_Chip-Seq_ESCs_Mouse	1.34796219
49	SMAD2/3_21741376_ChIP-Seq_EPCs_Human	1.33673420
50	SOX9_22984422_ChIP-ChIP_TESTIS_Rat	1.33318945
51	AR_21572438_ChIP-Seq_LNCaP_Human	1.32761783
52	WDR5_24793694_ChIP-Seq_LNCAP_Human	1.30446847
53	SMAD3_21741376_ChIP-Seq_EPCs_Human	1.30193505
54	ZFP322A_24550733_ChIP-Seq_MESCs_Mouse	1.29471092
55	PCGF2_27294783_Chip-Seq_ESCs_Mouse	1.27442318
56	KLF5_20875108_ChIP-Seq_MESCs_Mouse	1.25872895
57	TCF4_23295773_ChIP-Seq_U87_Human	1.25555783
58	PRDM16_22522345_ChIP-ChIP_PALATE_MESENCHYMAL_Mouse	1.24345796
59	FLI1_27457419_Chip-Seq_LIVER_Mouse	1.23341258
60	SMAD4_21741376_ChIP-Seq_EPCs_Human	1.23015846
61	EBNA1_20929547_Chip-Seq_RAJI-cells_Human	1.22033664
62	PADI4_21655091_ChIP-ChIP_MCF-7_Human	1.21679772
63	MYC_20876797_ChIP-ChIP_MEDULLOBLASTOMA_Human	1.21611720
64	RUNX2_22187159_ChIP-Seq_PCA_Human	1.20667673
65	YY1_22570637_ChIP-Seq_MALME-3M_Human	1.20660061
66	NR4A2_19515692_ChIP-ChIP_MN9D_Mouse	1.20409119
67	CREM_20920259_ChIP-Seq_GC1-SPG_Mouse	1.18023453
68	TOP2B_26459242_ChIP-Seq_MCF-7_Human	1.16613571
69	AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human	1.16569971
70	RCOR1_19997604_ChIP-ChIP_NEURONS_Mouse	1.16185833
71	LMO2_26923725_Chip-Seq_MACROPHAGESS_Mouse	1.15140441
72	GRHL2_25758223_ChIP-Seq_PLACENTA_Mouse	1.11765152
73	ERA_21632823_ChIP-Seq_H3396_Human	1.11279662
74	RXR_22108803_ChIP-Seq_LS180_Human	1.11063271
75	MEIS1_26253404_ChIP-Seq_OPTIC_CUPS_Mouse	1.09370449
76	NANOG_18555785_Chip-Seq_ESCs_Mouse	1.08940283
77	FOXP2_21765815_ChIP-ChIP_NEURO2A_Mouse	1.08692063
78	KDM2B_26808549_Chip-Seq_REH_Human	1.06681281
79	GATA1_26923725_Chip-Seq_HPCs_Mouse	1.05723970
80	POU5F1_16153702_ChIP-ChIP_HESCs_Human	1.05621931
81	E2F4_17652178_ChIP-ChIP_JURKAT_Human	1.02926928
82	JARID2_20064375_ChIP-Seq_MESCs_Mouse	1.02355247
83	CEBPA_26348894_ChIP-Seq_LIVER_Mouse	1.02099663
84	PPARG_23326641_ChIP-Seq_C3H10T1-2_Mouse	1.01024336
85	P53_22127205_ChIP-Seq_FIBROBLAST_Human	1.00158131
86	FOXA1_21572438_ChIP-Seq_LNCaP_Human	0.99857735
87	MYC_18940864_ChIP-ChIP_HL60_Human	0.99804290
88	TAL1_26923725_Chip-Seq_HPCs_Mouse	0.99765308
89	HOXB7_26014856_ChIP-Seq_BT474_Human	0.99402933
90	GABP_17652178_ChIP-ChIP_JURKAT_Human	0.99140952
91	HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse	0.97488319
92	YY1_21170310_ChIP-Seq_MESCs_Mouse	0.96316561
93	TCFCP2L1_18555785_Chip-Seq_ESCs_Mouse	0.95943229
94	FOXH1_21741376_ChIP-Seq_EPCs_Human	0.94364488
95	SOX9_26525672_Chip-Seq_HEART_Mouse	0.93205783
96	CRX_20693478_ChIP-Seq_ADULT_RETINA_Mouse	0.93144874
97	JARID2_20075857_ChIP-Seq_MESCs_Mouse	0.92135470
98	TP53_22573176_ChIP-Seq_HFKS_Human	0.91675114
99	CIITA_18437201_ChIP-ChIP_Raji_B_and_iDC_Human	0.90666072
100	E2F1_18555785_Chip-Seq_ESCs_Mouse	0.90401373

Predicted mouse phenotypes (MGI)

Rank	Gene Set	Z-score
1	MP0008877_abnormal_DNA_methylation	5.38715941
2	MP0005410_abnormal_fertilization	3.24137404
3	MP0000049_abnormal_middle_ear	2.96380852
4	MP0002160_abnormal_reproductive_system	2.94540040
5	MP0000569_abnormal_digit_pigmentation	2.90067401
6	MP0002102_abnormal_ear_morphology	2.84278138
7	MP0003937_abnormal_limbs/digits/tail_de	2.66943173
8	MP0005409_darkened_coat_color	2.61022309
9	MP0003698_abnormal_male_reproductive	2.57923418
10	MP0001929_abnormal_gametogenesis	2.57767587
11	MP0000383_abnormal_hair_follicle	2.56642754
12	MP0002210_abnormal_sex_determination	2.52254227
13	MP0002249_abnormal_larynx_morphology	2.43460799
14	MP0003119_abnormal_digestive_system	2.21445766
15	MP0010678_abnormal_skin_adnexa	2.19277567
16	MP0003646_muscle_fatigue	2.18532735
17	MP0002138_abnormal_hepatobiliary_system	2.15731919
18	MP0001145_abnormal_male_reproductive	1.93652957
19	MP0000427_abnormal_hair_cycle	1.89707290
20	MP0002089_abnormal_postnatal_growth/wei	1.88336707
21	MP0000678_abnormal_parathyroid_gland	1.84910801
22	MP0005389_reproductive_system_phenotype	1.83838771
23	MP0003693_abnormal_embryo_hatching	1.82334848
24	MP0000653_abnormal_sex_gland	1.77750614
25	MP0008789_abnormal_olfactory_epithelium	1.75644399
26	MP0005670_abnormal_white_adipose	1.74837768
27	MP0001188_hyperpigmentation	1.71798003
28	MP0005174_abnormal_tail_pigmentation	1.70461223
29	MP0003938_abnormal_ear_development	1.63763913
30	MP0004885_abnormal_endolymph	1.59754399
31	MP0001984_abnormal_olfaction	1.41661598
32	MP0004036_abnormal_muscle_relaxation	1.34320344
33	MP0008058_abnormal_DNA_repair	1.31961119
34	MP0002184_abnormal_innervation	1.31841602
35	MP0002161_abnormal_fertility/fecundity	1.31741049
36	MP0000013_abnormal_adipose_tissue	1.30863625
37	MP0005084_abnormal_gallbladder_morpholo	1.28729862
38	MP0000747_muscle_weakness	1.25462253
39	MP0000015_abnormal_ear_pigmentation	1.24899092
40	MP0003115_abnormal_respiratory_system	1.24328730
41	MP0005499_abnormal_olfactory_system	1.23556585
42	MP0005394_taste/olfaction_phenotype	1.23556585
43	MP0002177_abnormal_outer_ear	1.21778391
44	MP0002233_abnormal_nose_morphology	1.21397108
45	MP0002084_abnormal_developmental_patter	1.21002603
46	MP0000647_abnormal_sebaceous_gland	1.20297143
47	MP0006292_abnormal_olfactory_placode	1.20083749
48	MP0001486_abnormal_startle_reflex	1.17318562
49	MP0002282_abnormal_trachea_morphology	1.16637448
50	MP0000778_abnormal_nervous_system	1.16452893
51	MP0000631_abnormal_neuroendocrine_gland	1.16265672
52	MP0008995_early_reproductive_senescence	1.14529647
53	MP0001485_abnormal_pinna_reflex	1.07445299
54	MP0002928_abnormal_bile_duct	1.07401852
55	MP0001879_abnormal_lymphatic_vessel	1.06103411
56	MP0006035_abnormal_mitochondrial_morpho	1.05418908
57	MP0003755_abnormal_palate_morphology	1.02509705
58	MP0002272_abnormal_nervous_system	1.01348499
59	MP0005253_abnormal_eye_physiology	1.00950420
60	MP0003861_abnormal_nervous_system	0.99761919
61	MP0008057_abnormal_DNA_replication	0.97527638
62	MP0006072_abnormal_retinal_apoptosis	0.97447650
63	MP0001661_extended_life_span	0.95795790
64	MP0010368_abnormal_lymphatic_system	0.91133060
65	MP0002095_abnormal_skin_pigmentation	0.90139156
66	MP0005379_endocrine/exocrine_gland_phen	0.88666069
67	MP0003136_yellow_coat_color	0.86567526
68	MP0003936_abnormal_reproductive_system	0.86335898
69	MP0004859_abnormal_synaptic_plasticity	0.85905936
70	MP0003935_abnormal_craniofacial_develop	0.84135322
71	MP0002269_muscular_atrophy	0.83789276
72	MP0002127_abnormal_cardiovascular_syste	0.83521728
73	MP0000613_abnormal_salivary_gland	0.83110086
74	MP0001919_abnormal_reproductive_system	0.81111742
75	MP0002234_abnormal_pharynx_morphology	0.81046875
76	MP0001119_abnormal_female_reproductive	0.80108139
77	MP0004742_abnormal_vestibular_system	0.79830435
78	MP0003959_abnormal_lean_body	0.78352079
79	MP0001968_abnormal_touch/_nociception	0.78310978
80	MP0000026_abnormal_inner_ear	0.78240766
81	MP0010094_abnormal_chromosome_stability	0.78047954
82	MP0000955_abnormal_spinal_cord	0.74991109
83	MP0009053_abnormal_anal_canal	0.74848526
84	MP0003077_abnormal_cell_cycle	0.74559894
85	MP0002085_abnormal_embryonic_tissue	0.74115837
86	MP0010234_abnormal_vibrissa_follicle	0.73466644
87	MP0002938_white_spotting	0.72374081
88	MP0002116_abnormal_craniofacial_bone	0.71550873
89	MP0001697_abnormal_embryo_size	0.70651734
90	MP0005551_abnormal_eye_electrophysiolog	0.69296897
91	MP0001529_abnormal_vocalization	0.68657771
92	MP0003786_premature_aging	0.68023448
93	MP0002163_abnormal_gland_morphology	0.66396786
94	MP0004142_abnormal_muscle_tone	0.66008866
95	MP0002114_abnormal_axial_skeleton	0.65539583
96	MP0002109_abnormal_limb_morphology	0.64681573
97	MP0004957_abnormal_blastocyst_morpholog	0.64510980
98	MP0002152_abnormal_brain_morphology	0.64426032
99	MP0003718_maternal_effect	0.64082339
100	MP0003635_abnormal_synaptic_transmissio	0.63996845

Predicted human phenotypes

Rank	Gene Set	Z-score
1	Horizontal nystagmus (HP:0000666)	4.55616634
2	Shoulder girdle muscle weakness (HP:0003547)	4.21498776
3	Type I transferrin isoform profile (HP:0003642)	3.71762810
4	Hyperkalemia (HP:0002153)	3.40719999
5	Abnormal protein glycosylation (HP:0012346)	3.39709515
6	Abnormal glycosylation (HP:0012345)	3.39709515
7	Abnormal isoelectric focusing of serum transferrin (HP:0003160)	3.39709515
8	Abnormal protein N-linked glycosylation (HP:0012347)	3.39709515
9	Volvulus (HP:0002580)	3.26143380
10	Gonadotropin excess (HP:0000837)	3.25485834
11	Nephronophthisis (HP:0000090)	3.16193927
12	Progressive inability to walk (HP:0002505)	3.09977057
13	Severe visual impairment (HP:0001141)	3.07728005
14	Conjunctival hamartoma (HP:0100780)	3.03036974
15	Abnormality of the lower motor neuron (HP:0002366)	3.00578749
16	Attenuation of retinal blood vessels (HP:0007843)	2.86297828
17	Abnormality of the renal medulla (HP:0100957)	2.75403640
18	Abnormal rod and cone electroretinograms (HP:0008323)	2.74698134
19	Rimmed vacuoles (HP:0003805)	2.62191241
20	Long clavicles (HP:0000890)	2.58989255
21	Pendular nystagmus (HP:0012043)	2.50194750
22	Hypoplastic pelvis (HP:0008839)	2.49790311
23	Intellectual disability, moderate (HP:0002342)	2.49324138
24	Osteomalacia (HP:0002749)	2.48837793
25	Inability to walk (HP:0002540)	2.45958279
26	Tubulointerstitial nephritis (HP:0001970)	2.35466309
27	Amyotrophic lateral sclerosis (HP:0007354)	2.33566869
28	Small hand (HP:0200055)	2.29447652
29	Abnormality of the proximal phalanges of the hand (HP:0009834)	2.27359569
30	Hypoplastic iliac wings (HP:0002866)	2.27092496
31	Absent rod-and cone-mediated responses on ERG (HP:0007688)	2.22701839
32	Abnormality of chloride homeostasis (HP:0011422)	2.20975954
33	Oligodactyly (hands) (HP:0001180)	2.17884015
34	Aplasia/Hypoplasia of the 1st metacarpal (HP:0010026)	2.14976709
35	Short 1st metacarpal (HP:0010034)	2.14976709
36	Progressive cerebellar ataxia (HP:0002073)	2.14733337
37	Short 4th metacarpal (HP:0010044)	2.11980304
38	Aplasia/Hypoplasia of the 4th metacarpal (HP:0010042)	2.11980304
39	Aplasia/Hypoplasia of the sternum (HP:0006714)	2.09947630
40	Intestinal atresia (HP:0011100)	2.08628017
41	Ectopic kidney (HP:0000086)	2.07465241
42	Pancreatic cysts (HP:0001737)	2.06765833
43	Hamartoma of the eye (HP:0010568)	2.02583100
44	Palpebral edema (HP:0100540)	2.02150439
45	Mesomelia (HP:0003027)	1.97195360
46	Abnormality of the phalanges of the 2nd finger (HP:0009541)	1.96063801
47	Bony spicule pigmentary retinopathy (HP:0007737)	1.94743583
48	Oligodactyly (HP:0012165)	1.93277925
49	2-3 toe syndactyly (HP:0004691)	1.91438616
50	Poor eye contact (HP:0000817)	1.88859222
51	Abnormality of potassium homeostasis (HP:0011042)	1.88791997
52	Aplasia/Hypoplasia involving the pelvis (HP:0009103)	1.88683209
53	Optic nerve hypoplasia (HP:0000609)	1.87472221
54	Aplasia/Hypoplasia of the fibula (HP:0006492)	1.87144060
55	Delayed CNS myelination (HP:0002188)	1.86428047
56	Short phalanx of the thumb (HP:0009660)	1.86276201
57	Short femoral neck (HP:0100864)	1.85047176
58	Absent phalangeal crease (HP:0006109)	1.84034093
59	Absent/shortened dynein arms (HP:0200106)	1.82549214
60	Dynein arm defect of respiratory motile cilia (HP:0012255)	1.82549214
61	Abnormality of the 1st metacarpal (HP:0010009)	1.82409471
62	Abolished electroretinogram (ERG) (HP:0000550)	1.81318536
63	Persistence of primary teeth (HP:0006335)	1.80446728
64	Abnormal finger flexion creases (HP:0006143)	1.79780281
65	Limb-girdle muscle weakness (HP:0003325)	1.79116623
66	Hypoplasia of the pons (HP:0012110)	1.78384923
67	Abnormality of the middle phalanges of the toes (HP:0010183)	1.77112933
68	Esotropia (HP:0000565)	1.75123684
69	Bulbous nose (HP:0000414)	1.74797555
70	Aplasia/Hypoplasia of the optic nerve (HP:0008058)	1.72599898
71	Hepatoblastoma (HP:0002884)	1.72386218
72	Truncal obesity (HP:0001956)	1.71868717
73	Preaxial hand polydactyly (HP:0001177)	1.70259374
74	Abnormality of DNA repair (HP:0003254)	1.66541993
75	Pancreatic fibrosis (HP:0100732)	1.66461485
76	Decreased central vision (HP:0007663)	1.65883017
77	Abnormality of macular pigmentation (HP:0008002)	1.65445446
78	Fibular aplasia (HP:0002990)	1.65314524
79	Mask-like facies (HP:0000298)	1.64534641
80	Menstrual irregularities (HP:0000858)	1.64437410
81	Drooling (HP:0002307)	1.64301020
82	Furrowed tongue (HP:0000221)	1.63043946
83	Embryonal renal neoplasm (HP:0011794)	1.62321978
84	Fibular hypoplasia (HP:0003038)	1.61892001
85	Abnormal lung lobation (HP:0002101)	1.61886900
86	Neonatal respiratory distress (HP:0002643)	1.61644923
87	Nephroblastoma (Wilms tumor) (HP:0002667)	1.61390170
88	Epileptic encephalopathy (HP:0200134)	1.61280683
89	Molar tooth sign on MRI (HP:0002419)	1.60605857
90	Abnormality of midbrain morphology (HP:0002418)	1.60605857
91	Febrile seizures (HP:0002373)	1.60236190
92	Azoospermia (HP:0000027)	1.59341918
93	Disinhibition (HP:0000734)	1.58474264
94	Decreased circulating renin level (HP:0003351)	1.57236593
95	Abnormal respiratory motile cilium morphology (HP:0005938)	1.56383950
96	Abnormal respiratory epithelium morphology (HP:0012253)	1.56383950
97	True hermaphroditism (HP:0010459)	1.56269192
98	Cystic liver disease (HP:0006706)	1.54883538
99	Abnormality of the shoulder girdle musculature (HP:0001435)	1.54768868
100	Abnormality of chromosome segregation (HP:0002916)	1.54373651

Predicted kinase interactions (KEA)

Rank	Gene Set	Z-score
1	PNCK	8.35539236
2	MET	4.62177574
3	CAMK1G	3.85048074
4	PTK2B	2.89099224
5	PLK2	2.88130287
6	FGR	2.42889099
7	PLK4	2.33447794
8	CSF1R	2.26682313
9	DYRK3	2.26087942
10	NME2	2.25762665
11	BMX	2.23106425
12	CDK19	2.04190593
13	SRPK1	2.01964514
14	TRIM28	2.00090023
15	TAF1	1.93060046
16	NEK1	1.79017541
17	CASK	1.71222950
18	MAP4K2	1.70804214
19	NEK9	1.58739352
20	INSRR	1.43378007
21	NUAK1	1.36621286
22	RPS6KA4	1.27304459
23	WNK1	1.22547440
24	BRD4	1.22390784
25	PRKD3	1.21289065
26	TNIK	1.20090842
27	TSSK6	1.18687476
28	AKT3	1.18086736
29	BCR	1.15538500
30	TLK1	1.14375047
31	OXSR1	1.14255501
32	PDGFRB	1.08999232
33	DDR2	1.04236896
34	LATS1	1.00647389
35	STK38L	0.99775089
36	MAPK13	0.93787836
37	ADRBK2	0.92695379
38	RET	0.91462603
39	SGK2	0.89373871
40	EPHA4	0.75721347
41	CSNK1G2	0.75281065
42	MST1R	0.74509194
43	CSNK1A1L	0.70528589
44	SGK494	0.70256849
45	SGK223	0.70256849
46	ATR	0.70156673
47	CSNK1G3	0.68051718
48	CDK12	0.67956443
49	MAP3K4	0.65887217
50	STK16	0.64872294
51	CHEK1	0.59028813
52	VRK1	0.58762226
53	WNK4	0.58313818
54	PTK2	0.57647768
55	TIE1	0.56460063
56	CDK9	0.56254617
57	IRAK1	0.55723217
58	CSNK1G1	0.54485495
59	SGK3	0.52978108
60	PLK1	0.52722914
61	BRAF	0.52354955
62	EGFR	0.50651791
63	AURKA	0.50198378
64	PHKG2	0.49525412
65	PHKG1	0.49525412
66	PRKCE	0.49096386
67	CAMK1	0.48986987
68	ZAK	0.48698162
69	PLK3	0.48296870
70	CDK7	0.46800902
71	MAP3K9	0.45309515
72	MINK1	0.44140551
73	MST4	0.42042225
74	PRKCI	0.41855664
75	CHEK2	0.40855807
76	NEK2	0.40253806
77	TYRO3	0.35172826
78	CDK6	0.33891765
79	SGK1	0.33205369
80	MAP2K2	0.32026130
81	MKNK2	0.31403266
82	MAPK7	0.31087833
83	PASK	0.29557183
84	RPS6KA5	0.28612770
85	NEK6	0.28367861
86	DAPK2	0.28118621
87	MAP3K10	0.27676164
88	PRKCZ	0.26780546
89	YES1	0.26521176
90	CAMK1D	0.25418316
91	CSNK1E	0.25384049
92	STK38	0.23302610
93	ATM	0.22821372
94	ROCK1	0.22563264
95	RPS6KB1	0.22534976
96	TESK1	0.22437846
97	MAP2K7	0.20929428
98	CDK1	0.20866317
99	IGF1R	0.20673782
100	OBSCN	0.20031678

Predicted pathways (KEGG)

Rank	Gene Set	Z-score
1	Synthesis and degradation of ketone bodies_Homo sapiens_hsa00072	4.32362927
2	Basal transcription factors_Homo sapiens_hsa03022	3.17930300
3	RNA transport_Homo sapiens_hsa03013	2.87508260
4	mRNA surveillance pathway_Homo sapiens_hsa03015	2.85417696
5	Regulation of autophagy_Homo sapiens_hsa04140	2.66092671
6	Ribosome biogenesis in eukaryotes_Homo sapiens_hsa03008	2.65897350
7	Hedgehog signaling pathway_Homo sapiens_hsa04340	2.44894144
8	RNA degradation_Homo sapiens_hsa03018	2.44349247
9	Ubiquitin mediated proteolysis_Homo sapiens_hsa04120	2.43292122
10	Fanconi anemia pathway_Homo sapiens_hsa03460	2.38970423
11	Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa00534	2.30704098
12	Olfactory transduction_Homo sapiens_hsa04740	2.14624547
13	Spliceosome_Homo sapiens_hsa03040	2.11052161
14	Oocyte meiosis_Homo sapiens_hsa04114	1.91820772
15	Phototransduction_Homo sapiens_hsa04744	1.80016528
16	Taurine and hypotaurine metabolism_Homo sapiens_hsa00430	1.71753740
17	Nucleotide excision repair_Homo sapiens_hsa03420	1.67364550
18	Nicotine addiction_Homo sapiens_hsa05033	1.64003474
19	Maturity onset diabetes of the young_Homo sapiens_hsa04950	1.63887422
20	Butanoate metabolism_Homo sapiens_hsa00650	1.59807336
21	Tight junction_Homo sapiens_hsa04530	1.53185049
22	Cell cycle_Homo sapiens_hsa04110	1.52656821
23	Dorso-ventral axis formation_Homo sapiens_hsa04320	1.52396448
24	Morphine addiction_Homo sapiens_hsa05032	1.48425522
25	Homologous recombination_Homo sapiens_hsa03440	1.35577227
26	Progesterone-mediated oocyte maturation_Homo sapiens_hsa04914	1.33101443
27	Selenocompound metabolism_Homo sapiens_hsa00450	1.31039642
28	Nitrogen metabolism_Homo sapiens_hsa00910	1.28554076
29	Mismatch repair_Homo sapiens_hsa03430	1.25569551
30	Basal cell carcinoma_Homo sapiens_hsa05217	1.16101502
31	Taste transduction_Homo sapiens_hsa04742	1.13964725
32	Renin secretion_Homo sapiens_hsa04924	1.13951317
33	Neuroactive ligand-receptor interaction_Homo sapiens_hsa04080	1.09115086
34	RNA polymerase_Homo sapiens_hsa03020	1.08168351
35	Wnt signaling pathway_Homo sapiens_hsa04310	1.06355885
36	Fatty acid biosynthesis_Homo sapiens_hsa00061	1.05802505
37	Circadian entrainment_Homo sapiens_hsa04713	1.02900347
38	N-Glycan biosynthesis_Homo sapiens_hsa00510	0.96064124
39	Alcoholism_Homo sapiens_hsa05034	0.95963765
40	Axon guidance_Homo sapiens_hsa04360	0.95248125
41	Sulfur metabolism_Homo sapiens_hsa00920	0.94220065
42	ErbB signaling pathway_Homo sapiens_hsa04012	0.91490226
43	Gastric acid secretion_Homo sapiens_hsa04971	0.87992081
44	Circadian rhythm_Homo sapiens_hsa04710	0.87619677
45	MAPK signaling pathway_Homo sapiens_hsa04010	0.87421039
46	Transcriptional misregulation in cancer_Homo sapiens_hsa05202	0.86659338
47	Systemic lupus erythematosus_Homo sapiens_hsa05322	0.84470282
48	Calcium signaling pathway_Homo sapiens_hsa04020	0.82253654
49	Insulin secretion_Homo sapiens_hsa04911	0.80663621
50	Herpes simplex infection_Homo sapiens_hsa05168	0.78197208
51	alpha-Linolenic acid metabolism_Homo sapiens_hsa00592	0.77464228
52	Long-term potentiation_Homo sapiens_hsa04720	0.75486670
53	Adherens junction_Homo sapiens_hsa04520	0.73428854
54	DNA replication_Homo sapiens_hsa03030	0.71037038
55	Viral carcinogenesis_Homo sapiens_hsa05203	0.70491553
56	Purine metabolism_Homo sapiens_hsa00230	0.68732988
57	Retrograde endocannabinoid signaling_Homo sapiens_hsa04723	0.68437283
58	Glutamatergic synapse_Homo sapiens_hsa04724	0.67393620
59	Melanoma_Homo sapiens_hsa05218	0.64996448
60	Long-term depression_Homo sapiens_hsa04730	0.64648539
61	Fat digestion and absorption_Homo sapiens_hsa04975	0.62932768
62	Oxytocin signaling pathway_Homo sapiens_hsa04921	0.62077834
63	GABAergic synapse_Homo sapiens_hsa04727	0.59400744
64	Lysine degradation_Homo sapiens_hsa00310	0.59332017
65	Terpenoid backbone biosynthesis_Homo sapiens_hsa00900	0.59181813
66	Linoleic acid metabolism_Homo sapiens_hsa00591	0.58717268
67	Salivary secretion_Homo sapiens_hsa04970	0.57407077
68	Longevity regulating pathway - multiple species_Homo sapiens_hsa04213	0.57106586
69	Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa00250	0.56957631
70	Cardiac muscle contraction_Homo sapiens_hsa04260	0.56363482
71	Thyroid hormone signaling pathway_Homo sapiens_hsa04919	0.55316318
72	mTOR signaling pathway_Homo sapiens_hsa04150	0.53610991
73	Hippo signaling pathway_Homo sapiens_hsa04390	0.52985999
74	Non-homologous end-joining_Homo sapiens_hsa03450	0.51567844
75	Valine, leucine and isoleucine degradation_Homo sapiens_hsa00280	0.50463995
76	Proximal tubule bicarbonate reclamation_Homo sapiens_hsa04964	0.47662052
77	Estrogen signaling pathway_Homo sapiens_hsa04915	0.44621886
78	Huntingtons disease_Homo sapiens_hsa05016	0.43956654
79	Dopaminergic synapse_Homo sapiens_hsa04728	0.43058170
80	Ether lipid metabolism_Homo sapiens_hsa00565	0.42859739
81	cAMP signaling pathway_Homo sapiens_hsa04024	0.40870430
82	Epstein-Barr virus infection_Homo sapiens_hsa05169	0.40276180
83	cGMP-PKG signaling pathway_Homo sapiens_hsa04022	0.39415165
84	Protein processing in endoplasmic reticulum_Homo sapiens_hsa04141	0.39039756
85	Pyrimidine metabolism_Homo sapiens_hsa00240	0.38431142
86	Prostate cancer_Homo sapiens_hsa05215	0.37314925
87	Arginine biosynthesis_Homo sapiens_hsa00220	0.35715199
88	Melanogenesis_Homo sapiens_hsa04916	0.34567418
89	Retinol metabolism_Homo sapiens_hsa00830	0.33566946
90	Antigen processing and presentation_Homo sapiens_hsa04612	0.33302327
91	Base excision repair_Homo sapiens_hsa03410	0.32196361
92	Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa00601	0.32017782
93	Arginine and proline metabolism_Homo sapiens_hsa00330	0.31285644
94	Gap junction_Homo sapiens_hsa04540	0.30826938
95	Type II diabetes mellitus_Homo sapiens_hsa04930	0.30089849
96	Cholinergic synapse_Homo sapiens_hsa04725	0.29385575
97	Regulation of actin cytoskeleton_Homo sapiens_hsa04810	0.28439310
98	beta-Alanine metabolism_Homo sapiens_hsa00410	0.27791334
99	TGF-beta signaling pathway_Homo sapiens_hsa04350	0.27653794
100	Small cell lung cancer_Homo sapiens_hsa05222	0.24227735

HNRNPH1P3

Functional Annotation Prediction

Predicted biological processes (GO)

Predicted upstream transcription factors (ChEA)

Predicted mouse phenotypes (MGI)

Predicted human phenotypes

Predicted kinase interactions (KEA)

Predicted pathways (KEGG)

Most similar genes based on co-expression Upload to Enrichr

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