HNRNPH2

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: This gene belongs to the subfamily of ubiquitously expressed heterogeneous nuclear ribonucleoproteins (hnRNPs). The hnRNPs are RNA binding proteins and they complex with heterogeneous nuclear RNA (hnRNA). These proteins are associated with pre-mRNAs in the nucleus and appear to influence pre-mRNA processing and other aspects of mRNA metabolism and transport. While all of the hnRNPs are present in the nucleus some seem to shuttle between the nucleus and the cytoplasm. The hnRNP proteins have distinct nucleic acid binding properties. The protein encoded by this gene has three repeats of quasi-RRM domains that binds to RNAs. It is very similar to the family member HNRPH1. This gene is thought to be involved in Fabray disease and X-linked agammaglobulinemia phenotype. Alternative splicing results in multiple transcript variants encoding the same protein. Read-through transcription between this locus and the ribosomal protein L36a gene has been observed. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1synaptic vesicle docking involved in exocytosis (GO:0016081)5.31648132
2positive regulation of mitochondrial fission (GO:0090141)4.15300840
3cholesterol biosynthetic process (GO:0006695)4.03218841
4synaptic vesicle exocytosis (GO:0016079)4.03104756
5fatty acid elongation (GO:0030497)3.78952477
6neurotransmitter-gated ion channel clustering (GO:0072578)3.76628996
7regulation of N-methyl-D-aspartate selective glutamate receptor activity (GO:2000310)3.71150878
8sterol biosynthetic process (GO:0016126)3.70318811
9histone H2A acetylation (GO:0043968)3.67853660
10regulation of synaptic vesicle exocytosis (GO:2000300)3.67134075
11L-methionine biosynthetic process from methylthioadenosine (GO:0019509)3.62359813
12negative regulation of DNA recombination (GO:0045910)3.60051052
13presynaptic membrane assembly (GO:0097105)3.54196487
14dosage compensation (GO:0007549)3.52963896
15cullin deneddylation (GO:0010388)3.51293402
16transferrin transport (GO:0033572)3.51273688
17proteasome assembly (GO:0043248)3.50148460
18replication fork processing (GO:0031297)3.48192054
19positive regulation of synapse maturation (GO:0090129)3.41206163
20protein deneddylation (GO:0000338)3.36983837
21positive regulation of intracellular steroid hormone receptor signaling pathway (GO:0033145)3.36728234
22DNA damage response, detection of DNA damage (GO:0042769)3.35466683
23ribosome assembly (GO:0042255)3.31990069
24maturation of 5.8S rRNA (GO:0000460)3.25665696
25trivalent inorganic cation transport (GO:0072512)3.24807284
26ferric iron transport (GO:0015682)3.24807284
27regulation of DNA endoreduplication (GO:0032875)3.24333207
28ribonucleoprotein complex disassembly (GO:0032988)3.23841878
29negative regulation of mast cell activation (GO:0033004)3.23180311
30DNA topological change (GO:0006265)3.22978328
31negative regulation of synaptic transmission, GABAergic (GO:0032229)3.22764232
32establishment of integrated proviral latency (GO:0075713)3.21448231
33postsynaptic membrane organization (GO:0001941)3.18108824
34protein localization to cilium (GO:0061512)3.17441029
35regulation of alpha-amino-3-hydroxy-5-methyl-4-isoxazole propionate selective glutamate receptor act3.16800005
36regulation of cofactor metabolic process (GO:0051193)3.14909678
37regulation of coenzyme metabolic process (GO:0051196)3.14909678
38viral mRNA export from host cell nucleus (GO:0046784)3.14717443
39DNA double-strand break processing (GO:0000729)3.13917851
40L-serine transport (GO:0015825)3.13651520
41regulation of single stranded viral RNA replication via double stranded DNA intermediate (GO:00450913.12851611
42negative regulation of mRNA splicing, via spliceosome (GO:0048025)3.12033226
43presynaptic membrane organization (GO:0097090)3.11838441
44regulation of synaptic vesicle transport (GO:1902803)3.08860839
45glutamate secretion (GO:0014047)3.08042279
46pyrimidine nucleobase catabolic process (GO:0006208)3.07692820
47isoprenoid biosynthetic process (GO:0008299)3.05909580
48vocalization behavior (GO:0071625)3.05875793
49positive regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051437)3.05508046
50regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051439)3.05335228
51long-term synaptic potentiation (GO:0060291)3.04534615
52negative regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051436)3.04457494
53branched-chain amino acid catabolic process (GO:0009083)3.03464720
54platelet dense granule organization (GO:0060155)3.01557306
55L-methionine biosynthetic process (GO:0071265)3.01122966
56amino acid salvage (GO:0043102)3.01122966
57L-methionine salvage (GO:0071267)3.01122966
58negative regulation of dendrite morphogenesis (GO:0050774)3.00715324
59organelle disassembly (GO:1903008)2.99965922
60definitive hemopoiesis (GO:0060216)2.99742590
61regulation of acetyl-CoA biosynthetic process from pyruvate (GO:0010510)2.97116448
62phagosome maturation (GO:0090382)2.94110392
63peptidyl-cysteine modification (GO:0018198)2.93887962
64regulation of acyl-CoA biosynthetic process (GO:0050812)2.91913691
65negative regulation of neurological system process (GO:0031645)2.91449072
66double-strand break repair via nonhomologous end joining (GO:0006303)2.91051106
67non-recombinational repair (GO:0000726)2.91051106
68neuron cell-cell adhesion (GO:0007158)2.91001720
69protein K11-linked ubiquitination (GO:0070979)2.89150699
70startle response (GO:0001964)2.88421165
71DNA integration (GO:0015074)2.87258005
72intraciliary transport (GO:0042073)2.86982062
73ATP hydrolysis coupled proton transport (GO:0015991)2.86956000
74energy coupled proton transmembrane transport, against electrochemical gradient (GO:0015988)2.86956000
75regulation of glutamate receptor signaling pathway (GO:1900449)2.86108340
76vesicle docking involved in exocytosis (GO:0006904)2.84950879
77regulation of synapse maturation (GO:0090128)2.84845779
78regulation of cellular amino acid metabolic process (GO:0006521)2.84081583
79mitochondrial genome maintenance (GO:0000002)2.82503082
80preassembly of GPI anchor in ER membrane (GO:0016254)2.81082948
81regulation of respiratory system process (GO:0044065)2.80729676
82regulation of sulfur metabolic process (GO:0042762)2.77667543
83gamma-aminobutyric acid signaling pathway (GO:0007214)2.76605809
84vesicle docking (GO:0048278)2.76545489
85regulation of ER to Golgi vesicle-mediated transport (GO:0060628)2.76179472
86negative regulation of phagocytosis (GO:0050765)2.76030414
87sister chromatid segregation (GO:0000819)2.76000230
88membrane budding (GO:0006900)2.75846169
89maintenance of fidelity involved in DNA-dependent DNA replication (GO:0045005)2.75759809
90lipid particle organization (GO:0034389)2.73057731
91negative regulation of ubiquitin-protein transferase activity (GO:0051444)2.72882549
92negative regulation of ligase activity (GO:0051352)2.72882549
93ubiquinone metabolic process (GO:0006743)2.72274791
94mRNA splice site selection (GO:0006376)2.72095787
95anaphase-promoting complex-dependent proteasomal ubiquitin-dependent protein catabolic process (GO:02.71344058
96iron-sulfur cluster assembly (GO:0016226)2.71204326
97metallo-sulfur cluster assembly (GO:0031163)2.71204326
98histone mRNA metabolic process (GO:0008334)2.70789594
99DNA ligation (GO:0006266)2.70481211
100protein localization to synapse (GO:0035418)2.69404990
101establishment of viral latency (GO:0019043)2.69342721
102glycosphingolipid biosynthetic process (GO:0006688)2.68804290
103GPI anchor metabolic process (GO:0006505)2.68054143
104C-terminal protein lipidation (GO:0006501)2.67971636
105regulation of oxidative stress-induced neuron death (GO:1903203)2.67327263
106positive regulation of dendritic spine morphogenesis (GO:0061003)2.64848967
107nucleobase catabolic process (GO:0046113)2.63884117
108positive regulation of ubiquitin-protein transferase activity (GO:0051443)2.63518687
109synaptic vesicle endocytosis (GO:0048488)2.63427264
110mitotic sister chromatid segregation (GO:0000070)2.63170533
111sleep (GO:0030431)2.62832705
112anterograde synaptic vesicle transport (GO:0048490)2.62770147
113COPI coating of Golgi vesicle (GO:0048205)2.62105793
114Golgi transport vesicle coating (GO:0048200)2.62105793
115negative regulation of RNA splicing (GO:0033119)2.61881672
116positive regulation of protein homodimerization activity (GO:0090073)2.59930896
117neuron-neuron synaptic transmission (GO:0007270)2.59863198
118regulation of short-term neuronal synaptic plasticity (GO:0048172)2.59511122
119respiratory chain complex IV assembly (GO:0008535)2.59362221
120magnesium ion transport (GO:0015693)2.59235828
121regulation of Arp2/3 complex-mediated actin nucleation (GO:0034315)2.59216991
122GPI anchor biosynthetic process (GO:0006506)2.58976277
123positive regulation of excitatory postsynaptic membrane potential (GO:2000463)2.57007207
124C-terminal protein amino acid modification (GO:0018410)2.55728241
125exonucleolytic nuclear-transcribed mRNA catabolic process involved in deadenylation-dependent decay 2.54936219
126DNA strand renaturation (GO:0000733)2.54343318
127positive regulation of actin filament depolymerization (GO:0030836)2.54001162
128regulation of mitotic cell cycle spindle assembly checkpoint (GO:0090266)2.53033544
129regulation of mitotic spindle checkpoint (GO:1903504)2.53033544
130postreplication repair (GO:0006301)2.52915103
131RNA phosphodiester bond hydrolysis, exonucleolytic (GO:0090503)2.52738951
132regulation of mitochondrial fission (GO:0090140)2.52610349
133positive regulation of mitochondrial membrane permeability involved in apoptotic process (GO:19021102.52334164
134mitochondrial outer membrane permeabilization involved in programmed cell death (GO:1902686)2.52334164
135peroxisome organization (GO:0007031)2.51875805
136neurotransmitter secretion (GO:0007269)2.51448698
137regulation of helicase activity (GO:0051095)2.51007084
138nuclear-transcribed mRNA catabolic process, exonucleolytic (GO:0000291)2.50987133
139positive regulation of ligase activity (GO:0051351)2.50964404
140NADH metabolic process (GO:0006734)2.50552192
141somatic diversification of immune receptors via somatic mutation (GO:0002566)2.50532424
142somatic hypermutation of immunoglobulin genes (GO:0016446)2.50532424
143de novo protein folding (GO:0006458)2.50231303
144glycolipid biosynthetic process (GO:0009247)2.49059940
145cerebellar granule cell differentiation (GO:0021707)2.48833730
146DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest (GO:002.47681544
147succinate metabolic process (GO:0006105)2.46055309
148tricarboxylic acid cycle (GO:0006099)2.45434163
149IMP biosynthetic process (GO:0006188)2.43435759
150mitotic spindle checkpoint (GO:0071174)2.42338357
151synaptic vesicle maturation (GO:0016188)2.42002414
152positive regulation of neurotransmitter secretion (GO:0001956)2.41631096
153de novo posttranslational protein folding (GO:0051084)2.41482555
154signal transduction involved in mitotic DNA damage checkpoint (GO:1902402)2.40660261
155signal transduction involved in mitotic cell cycle checkpoint (GO:0072413)2.40660261
156signal transduction involved in mitotic DNA integrity checkpoint (GO:1902403)2.40660261
157metaphase plate congression (GO:0051310)2.40538968
158purine nucleobase biosynthetic process (GO:0009113)2.40489851
159protein neddylation (GO:0045116)2.40387951
160melanosome transport (GO:0032402)2.39748267
161nonmotile primary cilium assembly (GO:0035058)2.39097267
162inositol phosphate catabolic process (GO:0071545)2.37209798
163synaptic vesicle transport (GO:0048489)2.35134347
164establishment of synaptic vesicle localization (GO:0097480)2.35134347
165negative regulation of histone acetylation (GO:0035067)2.32055773
166regulation of mRNA splicing, via spliceosome (GO:0048024)2.31859527
167synaptic transmission, glutamatergic (GO:0035249)2.31719302
168positive regulation of neurotransmitter transport (GO:0051590)2.30495603
169negative regulation of mRNA processing (GO:0050686)2.27624559
170positive regulation of cellular response to oxidative stress (GO:1900409)2.27417036
171positive regulation of response to oxidative stress (GO:1902884)2.27417036
172response to histamine (GO:0034776)2.27176593
173DNA catabolic process, exonucleolytic (GO:0000738)2.27167709
174telomere maintenance via semi-conservative replication (GO:0032201)2.26443052
175peptidyl-arginine methylation (GO:0018216)2.26277749
176peptidyl-arginine N-methylation (GO:0035246)2.26277749
177phagocytosis, engulfment (GO:0006911)2.26184769
178glucocorticoid receptor signaling pathway (GO:0042921)2.24641992
179regulation of respiratory gaseous exchange by neurological system process (GO:0002087)2.23748284
180base-excision repair, AP site formation (GO:0006285)2.23472469
181multi-organism localization (GO:1902579)2.21579644
182multi-organism intracellular transport (GO:1902583)2.21579644
183transport of virus (GO:0046794)2.21579644
184intracellular transport of virus (GO:0075733)2.21579644
185multi-organism transport (GO:0044766)2.21579644
186DNA unwinding involved in DNA replication (GO:0006268)2.20286808
187mitochondrial fragmentation involved in apoptotic process (GO:0043653)2.19512073
188neuronal action potential propagation (GO:0019227)2.19441187
189mRNA export from nucleus (GO:0006406)2.19124440

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1E2F7_22180533_ChIP-Seq_HELA_Human5.57393578
2IGF1R_20145208_ChIP-Seq_DFB_Human3.17831026
3GBX2_23144817_ChIP-Seq_PC3_Human3.05269063
4ZNF274_21170338_ChIP-Seq_K562_Hela2.68776095
5E2F4_17652178_ChIP-ChIP_JURKAT_Human2.66086613
6SMAD_19615063_ChIP-ChIP_OVARY_Human2.50679378
7RBPJ_22232070_ChIP-Seq_NCS_Mouse2.50470264
8FOXP3_17237761_ChIP-ChIP_TREG_Mouse2.46816537
9ELK1_19687146_ChIP-ChIP_HELA_Human2.38236043
10EST1_17652178_ChIP-ChIP_JURKAT_Human2.32600622
11YY1_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse2.28160698
12SALL1_21062744_ChIP-ChIP_HESCs_Human2.27602005
13NOTCH1_17114293_ChIP-ChIP_T-ALL_Human2.26114717
14HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse2.25992412
15HOXB4_20404135_ChIP-ChIP_EML_Mouse2.25015225
16ELF1_17652178_ChIP-ChIP_JURKAT_Human2.23626438
17PPARG_23326641_ChIP-Seq_C3H10T1-2_Mouse2.21366141
18CIITA_18437201_ChIP-ChIP_Raji_B_and_iDC_Human2.20621825
19TAF15_26573619_Chip-Seq_HEK293_Human2.14043128
20EKLF_21900194_ChIP-Seq_ERYTHROCYTE_Mouse2.09149040
21THAP11_20581084_ChIP-Seq_MESCs_Mouse2.06891246
22HCFC1_20581084_ChIP-Seq_MESCs_Mouse2.06853345
23FUS_26573619_Chip-Seq_HEK293_Human2.03498141
24KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human2.02992839
25KDM5B_21448134_ChIP-Seq_MESCs_Mouse2.02590152
26E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse2.01610265
27FOXM1_23109430_ChIP-Seq_U2OS_Human2.00134158
28IRF8_22096565_ChIP-ChIP_GC-B_Mouse1.99141740
29IRF8_21731497_ChIP-ChIP_J774_Mouse1.97303104
30GABP_17652178_ChIP-ChIP_JURKAT_Human1.96702473
31MYCN_21190229_ChIP-Seq_SHEP-21N_Human1.96580022
32EGR1_19374776_ChIP-ChIP_THP-1_Human1.96493889
33POU3F2_20337985_ChIP-ChIP_501MEL_Human1.92080846
34FLI1_27457419_Chip-Seq_LIVER_Mouse1.91878412
35PDX1_19855005_ChIP-ChIP_MIN6_Mouse1.88117138
36MYC_18555785_ChIP-Seq_MESCs_Mouse1.84244821
37VDR_23849224_ChIP-Seq_CD4+_Human1.82790398
38SMARCA4_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.80709895
39EWS_26573619_Chip-Seq_HEK293_Human1.79289151
40CEBPD_23245923_ChIP-Seq_MEFs_Mouse1.75967610
41JARID1A_20064375_ChIP-Seq_MESCs_Mouse1.74217274
42HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human1.73786925
43PADI4_21655091_ChIP-ChIP_MCF-7_Human1.70954557
44FOXO3_22982991_ChIP-Seq_MACROPHAGES_Mouse1.69223015
45STAT6_20620947_ChIP-Seq_CD4_POS_T_Human1.67016320
46CTBP2_25329375_ChIP-Seq_LNCAP_Human1.66155684
47SPI1_22096565_ChIP-ChIP_GC-B_Mouse1.65394943
48ASXL1_24218140_ChIP-Seq_BMDM_Mouse1.62796817
49CREB1_15753290_ChIP-ChIP_HEK293T_Human1.62331992
50DMRT1_21621532_ChIP-ChIP_FETAL_Ovary1.61306001
51MECOM_23826213_ChIP-Seq_KASUMI_Mouse1.59932722
52SPI1_22790984_ChIP-Seq_ERYTHROLEUKEMIA_Mouse1.58367358
53VDR_22108803_ChIP-Seq_LS180_Human1.54964510
54RCOR1_19997604_ChIP-ChIP_NEURONS_Mouse1.54292097
55RUNX1_17652178_ChIP-ChIP_JURKAT_Human1.53713261
56FOXP3_21729870_ChIP-Seq_TREG_Human1.50872498
57SRF_21415370_ChIP-Seq_HL-1_Mouse1.49250771
58NELFA_20434984_ChIP-Seq_ESCs_Mouse1.47890743
59MYC_19030024_ChIP-ChIP_MESCs_Mouse1.46642323
60PCGF2_27294783_Chip-Seq_ESCs_Mouse1.43364414
61MYBL1_21750041_ChIP-ChIP_SPERMATOCYTES_Mouse1.42652742
62POU5F1_16153702_ChIP-ChIP_HESCs_Human1.42492282
63E2F1_21310950_ChIP-Seq_MCF-7_Human1.41563750
64PRDM5_23873026_ChIP-Seq_MEFs_Mouse1.41310181
65ETS1_20019798_ChIP-Seq_JURKAT_Human1.39995930
66MYC_20876797_ChIP-ChIP_MEDULLOBLASTOMA_Human1.38542572
67FOXM1_25889361_ChIP-Seq_OE33_AND_U2OS_Human1.36245762
68WT1_19549856_ChIP-ChIP_CCG9911_Human1.35168779
69P300_19829295_ChIP-Seq_ESCs_Human1.34827332
70AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human1.34766671
71MEIS1_26253404_ChIP-Seq_OPTIC_CUPS_Mouse1.33544767
72* TFEB_21752829_ChIP-Seq_HELA_Human1.32578951
73GFI1B_20887958_ChIP-Seq_HPC-7_Mouse1.30744884
74NANOG_18700969_ChIP-ChIP_MESCs_Mouse1.30013655
75IRF4_20064451_ChIP-Seq_CD4+T_Mouse1.28081659
76CBP_20019798_ChIP-Seq_JUKART_Human1.28081659
77ZFP57_27257070_Chip-Seq_ESCs_Mouse1.27587476
78GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.27359775
79CREB1_23762244_ChIP-Seq_HIPPOCAMPUS_Rat1.26632493
80ZFP281_18358816_ChIP-ChIP_MESCs_Mouse1.25833925
81CTBP1_25329375_ChIP-Seq_LNCAP_Human1.24218588
82MYC_18940864_ChIP-ChIP_HL60_Human1.23632655
83GLI1_17442700_ChIP-ChIP_MESCs_Mouse1.23433271
84DCP1A_22483619_ChIP-Seq_HELA_Human1.22645656
85EZH2_27294783_Chip-Seq_NPCs_Mouse1.21382689
86HTT_18923047_ChIP-ChIP_STHdh_Human1.20687945
87CCND1_20090754_ChIP-ChIP_RETINA_Mouse1.20054766
88CHD7_19251738_ChIP-ChIP_MESCs_Mouse1.19638002
89POU5F1_18555785_ChIP-Seq_MESCs_Mouse1.19560250
90NR4A2_19515692_ChIP-ChIP_MN9D_Mouse1.18262201
91MYBL2_22936984_ChIP-ChIP_MESCs_Mouse1.18211648
92SOX9_26525672_Chip-Seq_HEART_Mouse1.17997512
93FLI1_20887958_ChIP-Seq_HPC-7_Mouse1.17435426
94TP63_19390658_ChIP-ChIP_HaCaT_Human1.16824080
95ER_23166858_ChIP-Seq_MCF-7_Human1.14371311
96RARB_27405468_Chip-Seq_BRAIN_Mouse1.12699215
97SALL4_22934838_ChIP-ChIP_CD34+_Human1.12225667
98E2F1_18555785_ChIP-Seq_MESCs_Mouse1.11619760
99CHD1_19587682_ChIP-ChIP_MESCs_Mouse1.10896723
100MYC_18358816_ChIP-ChIP_MESCs_Mouse1.10356154
101SOX2_16153702_ChIP-ChIP_HESCs_Human1.09387137
102ZFP42_18358816_ChIP-ChIP_MESCs_Mouse1.08525799
103CIITA_25753668_ChIP-Seq_RAJI_Human1.08361563
104GABP_19822575_ChIP-Seq_HepG2_Human1.07960672
105MYCN_18555785_ChIP-Seq_MESCs_Mouse1.06482650
106NANOG_18555785_Chip-Seq_ESCs_Mouse1.06258758
107KLF5_20875108_ChIP-Seq_MESCs_Mouse1.06065455
108OLIG2_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.06064659
109UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human1.05045979
110IRF1_19129219_ChIP-ChIP_H3396_Human1.03729109
111SUZ12_27294783_Chip-Seq_NPCs_Mouse1.02840751
112* SFPI1_20887958_ChIP-Seq_HPC-7_Mouse1.01695593
113ESR1_15608294_ChIP-ChIP_MCF-7_Human1.00573816
114TAL1_20887958_ChIP-Seq_HPC-7_Mouse0.99904007
115TCFCP2L1_18555785_Chip-Seq_ESCs_Mouse0.99811377
116SMAD4_21799915_ChIP-Seq_A2780_Human0.99150483
117CDKN2AIP_20523734_ChIP-Seq_CORTICAL_Neurons0.98808085
118EBF1_22473956_ChIP-Seq_BONE_MARROW_Mouse0.98643584
119TOP2B_26459242_ChIP-Seq_MCF-7_Human0.98573661
120REST_18959480_ChIP-ChIP_MESCs_Mouse0.98505431
121FOXP2_21765815_ChIP-ChIP_NEURO2A_Mouse0.98007170
122YY1_21170310_ChIP-Seq_MESCs_Mouse0.97789085
123TAL1_26923725_Chip-Seq_HPCs_Mouse0.96966825
124SMAD2/3_21741376_ChIP-Seq_EPCs_Human0.96835268
125* SPI1_23547873_ChIP-Seq_NB4_Human0.96610997
126SMARCD1_25818293_ChIP-Seq_ESCs_Mouse0.96571092
127CREB1_20920259_ChIP-Seq_GC1-SPG_Mouse0.96566988
128TP53_22573176_ChIP-Seq_HFKS_Human0.95835486
129ERG_20887958_ChIP-Seq_HPC-7_Mouse0.94143497
130MYB_21317192_ChIP-Seq_ERMYB_Mouse0.93638533
131ZFX_18555785_ChIP-Seq_MESCs_Mouse0.93492047
132GRHL2_25758223_ChIP-Seq_PLACENTA_Mouse0.93385268
133SMAD3_21741376_ChIP-Seq_EPCs_Human0.93103155
134CRX_20693478_ChIP-Seq_RETINA_Mouse0.92053452
135NANOG_16153702_ChIP-ChIP_HESCs_Human0.91834066
136TTF2_22483619_ChIP-Seq_HELA_Human0.90866076
137FOXA1_21572438_ChIP-Seq_LNCaP_Human0.90620775
138KDM5A_27292631_Chip-Seq_BREAST_Human0.90423155
139SOX2_19030024_ChIP-ChIP_MESCs_Mouse0.89919511
140MYC_22102868_ChIP-Seq_BL_Human0.89917204
141JUN_21703547_ChIP-Seq_K562_Human0.89456137
142SOX2_19829295_ChIP-Seq_ESCs_Human0.87878615
143NANOG_19829295_ChIP-Seq_ESCs_Human0.87878615
144P53_22387025_ChIP-Seq_ESCs_Mouse0.87608755
145PIAS1_25552417_ChIP-Seq_VCAP_Human0.87524197
146NFE2_27457419_Chip-Seq_LIVER_Mouse0.87325406
147TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse0.86596523

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0003880_abnormal_central_pattern3.78644993
2MP0002102_abnormal_ear_morphology3.14322455
3MP0004859_abnormal_synaptic_plasticity2.93240890
4MP0003787_abnormal_imprinting2.72201496
5MP0003221_abnormal_cardiomyocyte_apopto2.65471509
6MP0008877_abnormal_DNA_methylation2.50056296
7MP0005171_absent_coat_pigmentation2.45396142
8MP0003635_abnormal_synaptic_transmissio2.41728442
9MP0002736_abnormal_nociception_after2.41173199
10MP0001188_hyperpigmentation2.40340829
11MP0009046_muscle_twitch2.38218201
12MP0001968_abnormal_touch/_nociception2.32176492
13MP0002064_seizures2.26663696
14MP0002063_abnormal_learning/memory/cond2.25505623
15MP0009745_abnormal_behavioral_response2.18441907
16MP0004270_analgesia2.11577578
17MP0005367_renal/urinary_system_phenotyp2.10181497
18MP0000516_abnormal_urinary_system2.10181497
19MP0008789_abnormal_olfactory_epithelium2.09378380
20MP0002909_abnormal_adrenal_gland1.97017859
21MP0005646_abnormal_pituitary_gland1.92725765
22MP0005394_taste/olfaction_phenotype1.91781690
23MP0005499_abnormal_olfactory_system1.91781690
24MP0002572_abnormal_emotion/affect_behav1.88170363
25MP0005084_abnormal_gallbladder_morpholo1.88088554
26MP0002837_dystrophic_cardiac_calcinosis1.87762329
27MP0010234_abnormal_vibrissa_follicle1.86412731
28MP0005253_abnormal_eye_physiology1.85570324
29MP0003123_paternal_imprinting1.85151361
30MP0010094_abnormal_chromosome_stability1.83510453
31MP0002735_abnormal_chemical_nociception1.83355078
32MP0008057_abnormal_DNA_replication1.83062558
33MP0002822_catalepsy1.82840503
34MP0006072_abnormal_retinal_apoptosis1.80969010
35MP0006054_spinal_hemorrhage1.79056167
36MP0003122_maternal_imprinting1.74828863
37MP0005248_abnormal_Harderian_gland1.71348509
38MP0002272_abnormal_nervous_system1.69318185
39MP0003121_genomic_imprinting1.64933521
40MP0002090_abnormal_vision1.64818511
41MP0001529_abnormal_vocalization1.64066263
42MP0003183_abnormal_peptide_metabolism1.63175571
43MP0004808_abnormal_hematopoietic_stem1.57043046
44MP0008007_abnormal_cellular_replicative1.55474136
45MP0009780_abnormal_chondrocyte_physiolo1.51699943
46MP0006036_abnormal_mitochondrial_physio1.50084527
47MP0003943_abnormal_hepatobiliary_system1.49268393
48MP0000681_abnormal_thyroid_gland1.48921873
49MP0003879_abnormal_hair_cell1.48121337
50MP0005397_hematopoietic_system_phenotyp1.48070174
51MP0001545_abnormal_hematopoietic_system1.48070174
52MP0004147_increased_porphyrin_level1.44483780
53MP0001501_abnormal_sleep_pattern1.44391534
54MP0002067_abnormal_sensory_capabilities1.44072159
55MP0005671_abnormal_response_to1.43034970
56MP0000647_abnormal_sebaceous_gland1.42279867
57MP0010678_abnormal_skin_adnexa1.41323642
58MP0006035_abnormal_mitochondrial_morpho1.37362951
59MP0006292_abnormal_olfactory_placode1.36227638
60MP0003806_abnormal_nucleotide_metabolis1.35585610
61MP0004811_abnormal_neuron_physiology1.35213368
62MP0001835_abnormal_antigen_presentation1.33538781
63MP0004215_abnormal_myocardial_fiber1.33010369
64MP0002751_abnormal_autonomic_nervous1.31750357
65MP0000372_irregular_coat_pigmentation1.30640118
66MP0008569_lethality_at_weaning1.28567048
67MP0003077_abnormal_cell_cycle1.27606972
68MP0008058_abnormal_DNA_repair1.27501264
69MP0003195_calcinosis1.26863133
70MP0009785_altered_susceptibility_to1.25925380
71MP0002396_abnormal_hematopoietic_system1.24584339
72MP0003724_increased_susceptibility_to1.23969163
73MP0001764_abnormal_homeostasis1.19742200
74MP0003718_maternal_effect1.19060704
75MP0002398_abnormal_bone_marrow1.15568440
76MP0004924_abnormal_behavior1.14771687
77MP0005386_behavior/neurological_phenoty1.14771687
78MP0001177_atelectasis1.13772585
79MP0000465_gastrointestinal_hemorrhage1.09524280
80MP0000383_abnormal_hair_follicle1.07889945
81MP0006276_abnormal_autonomic_nervous1.07165554
82MP0002876_abnormal_thyroid_physiology1.06564806
83MP0002734_abnormal_mechanical_nocicepti1.06189020
84MP0005075_abnormal_melanosome_morpholog1.05945585
85MP0004133_heterotaxia1.05697833
86MP0003011_delayed_dark_adaptation1.05649922
87MP0000427_abnormal_hair_cycle1.05066842
88MP0005551_abnormal_eye_electrophysiolog1.05052411
89MP0004484_altered_response_of1.04933085
90MP0004957_abnormal_blastocyst_morpholog1.04761582
91MP0000358_abnormal_cell_content/1.04624915
92MP0004233_abnormal_muscle_weight1.04085944
93MP0009278_abnormal_bone_marrow1.03805573
94MP0001970_abnormal_pain_threshold1.02951890
95MP0005187_abnormal_penis_morphology1.00165545
96MP0000015_abnormal_ear_pigmentation0.98203822
97MP0002233_abnormal_nose_morphology0.97736726
98MP0001986_abnormal_taste_sensitivity0.96928609
99MP0009333_abnormal_splenocyte_physiolog0.93304669
100MP0002877_abnormal_melanocyte_morpholog0.92080288
101MP0002420_abnormal_adaptive_immunity0.91970411
102MP0001819_abnormal_immune_cell0.90045715
103MP0001727_abnormal_embryo_implantation0.89748017
104MP0001502_abnormal_circadian_rhythm0.88078699
105MP0003119_abnormal_digestive_system0.87726557
106MP0001293_anophthalmia0.87566304
107MP0003693_abnormal_embryo_hatching0.87410417
108MP0000778_abnormal_nervous_system0.86907550
109MP0009697_abnormal_copulation0.85926738
110MP0000013_abnormal_adipose_tissue0.85207557
111MP0000689_abnormal_spleen_morphology0.84232300
112MP0010386_abnormal_urinary_bladder0.83571538
113MP0002234_abnormal_pharynx_morphology0.83517878
114MP0008260_abnormal_autophagy0.83478032
115MP0004782_abnormal_surfactant_physiolog0.82209797
116MP0002184_abnormal_innervation0.80833279
117MP0001905_abnormal_dopamine_level0.80429229
118MP0005391_vision/eye_phenotype0.80172148
119MP0002419_abnormal_innate_immunity0.79690725
120MP0002452_abnormal_antigen_presenting0.78912420
121MP0002557_abnormal_social/conspecific_i0.78880894
122MP0003633_abnormal_nervous_system0.78784059
123MP0003786_premature_aging0.78056134
124MP0003656_abnormal_erythrocyte_physiolo0.77673082
125MP0000703_abnormal_thymus_morphology0.77464848
126MP0000350_abnormal_cell_proliferation0.77076866
127MP0005000_abnormal_immune_tolerance0.76818280
128MP0001486_abnormal_startle_reflex0.76597529
129MP0000716_abnormal_immune_system0.76324381
130MP0002429_abnormal_blood_cell0.75941760
131MP0008995_early_reproductive_senescence0.75484552
132MP0002733_abnormal_thermal_nociception0.75462474
133MP0002095_abnormal_skin_pigmentation0.74992433
134MP0002148_abnormal_hypersensitivity_rea0.74535041
135MP0002722_abnormal_immune_system0.73038939
136MP0002653_abnormal_ependyma_morphology0.71701269
137MP0002723_abnormal_immune_serum0.69535502
138MP0003567_abnormal_fetal_cardiomyocyte0.69338281
139MP0003631_nervous_system_phenotype0.68879782
140MP0010307_abnormal_tumor_latency0.68845141
141MP0001800_abnormal_humoral_immune0.68809916
142MP0010352_gastrointestinal_tract_polyps0.68393914
143MP0005423_abnormal_somatic_nervous0.68335540
144MP0002066_abnormal_motor_capabilities/c0.68324163
145MP0000631_abnormal_neuroendocrine_gland0.68180399
146MP0003186_abnormal_redox_activity0.67290132
147MP0002069_abnormal_eating/drinking_beha0.66726858
148MP0001542_abnormal_bone_strength0.65810330
149MP0005645_abnormal_hypothalamus_physiol0.65534991
150MP0003111_abnormal_nucleus_morphology0.64702841
151MP0005220_abnormal_exocrine_pancreas0.64076573
152MP0002277_abnormal_respiratory_mucosa0.63252213
153MP0002928_abnormal_bile_duct0.62987155
154MP0001984_abnormal_olfaction0.62487817
155MP0002229_neurodegeneration0.62310622
156MP0008932_abnormal_embryonic_tissue0.60975137
157MP0003890_abnormal_embryonic-extraembry0.59929575
158MP0002009_preneoplasia0.59379218

Predicted human phenotypes

RankGene SetZ-score
1Abnormal hair whorl (HP:0010721)5.58884107
2Focal motor seizures (HP:0011153)4.98893751
3Atonic seizures (HP:0010819)4.98116939
4Epileptic encephalopathy (HP:0200134)4.78870084
5Febrile seizures (HP:0002373)4.49245212
6Hyperventilation (HP:0002883)3.75188503
7Birth length less than 3rd percentile (HP:0003561)3.61192802
8Methylmalonic acidemia (HP:0002912)3.02987747
9Papillary thyroid carcinoma (HP:0002895)2.96392713
10Hyperglycinemia (HP:0002154)2.90955746
11Thyroid carcinoma (HP:0002890)2.89193389
12Absence seizures (HP:0002121)2.86194381
13Agnosia (HP:0010524)2.85094618
14Focal seizures (HP:0007359)2.83002916
15Amyotrophic lateral sclerosis (HP:0007354)2.77964993
16Dialeptic seizures (HP:0011146)2.72350174
17Rectal fistula (HP:0100590)2.69815354
18Rectovaginal fistula (HP:0000143)2.69815354
19Visual hallucinations (HP:0002367)2.69202021
20Cortical dysplasia (HP:0002539)2.67507172
21Medulloblastoma (HP:0002885)2.66647940
22Genital tract atresia (HP:0001827)2.64920468
23Protruding tongue (HP:0010808)2.64721666
24Short tibia (HP:0005736)2.63882023
25Hypothermia (HP:0002045)2.58316070
26Exercise-induced muscle cramps (HP:0003710)2.56274150
27Resting tremor (HP:0002322)2.55355830
28Abnormality of the hip-girdle musculature (HP:0001445)2.49166640
29Abnormality of the musculature of the pelvis (HP:0001469)2.49166640
30Vaginal atresia (HP:0000148)2.48463191
31Intestinal fistula (HP:0100819)2.47230184
32Volvulus (HP:0002580)2.44158818
33Methylmalonic aciduria (HP:0012120)2.41381827
34Abnormality of the labia minora (HP:0012880)2.39128664
35Neoplasm of the adrenal gland (HP:0100631)2.34324852
36Spinal canal stenosis (HP:0003416)2.31852551
37Heterochromia iridis (HP:0001100)2.29244126
38Degeneration of anterior horn cells (HP:0002398)2.29080819
39Abnormality of the anterior horn cell (HP:0006802)2.29080819
40Hypoglycemic seizures (HP:0002173)2.27023240
41Fetal akinesia sequence (HP:0001989)2.26634396
42Abnormality of serine family amino acid metabolism (HP:0010894)2.25974378
43Abnormality of glycine metabolism (HP:0010895)2.25974378
44Aplasia/Hypoplasia of the tibia (HP:0005772)2.24944486
45Poor suck (HP:0002033)2.23549083
46Congenital primary aphakia (HP:0007707)2.22071606
47Growth hormone excess (HP:0000845)2.21026200
48Shoulder girdle muscle weakness (HP:0003547)2.20737051
49Abnormality of alanine metabolism (HP:0010916)2.20583113
50Hyperalaninemia (HP:0003348)2.20583113
51Abnormality of pyruvate family amino acid metabolism (HP:0010915)2.20583113
52Nephrogenic diabetes insipidus (HP:0009806)2.19166744
53Hyperinsulinemic hypoglycemia (HP:0000825)2.19033815
54Neoplasm of the peripheral nervous system (HP:0100007)2.17706085
55Neuroendocrine neoplasm (HP:0100634)2.17559578
56Annular pancreas (HP:0001734)2.12758091
57Polyphagia (HP:0002591)2.12507911
58Unilateral renal agenesis (HP:0000122)2.12368033
59Type 2 muscle fiber atrophy (HP:0003554)2.11627482
60Broad-based gait (HP:0002136)2.11199719
61Tongue fasciculations (HP:0001308)2.10938456
62Tubulointerstitial nephritis (HP:0001970)2.10779841
63Renal cortical cysts (HP:0000803)2.10377683
64Drooling (HP:0002307)2.09611540
65Excessive salivation (HP:0003781)2.09611540
66Gait imbalance (HP:0002141)2.09146716
67Progressive inability to walk (HP:0002505)2.08241329
68Abnormality of serum amino acid levels (HP:0003112)2.08164339
69Pancreatic fibrosis (HP:0100732)2.07965931
70Abnormality of the metopic suture (HP:0005556)2.06945454
71Increased IgM level (HP:0003496)2.06788575
72Medial flaring of the eyebrow (HP:0010747)2.05781507
73Colon cancer (HP:0003003)2.05548347
74Narrow nasal bridge (HP:0000446)2.05429672
75True hermaphroditism (HP:0010459)2.05416209
76Hypoglycemic coma (HP:0001325)2.03281157
77Vaginal fistula (HP:0004320)2.03108311
78Pancreatic islet-cell hyperplasia (HP:0004510)2.02400457
79Spastic diplegia (HP:0001264)2.02132056
80Generalized myoclonic seizures (HP:0002123)2.01683583
81Menstrual irregularities (HP:0000858)1.99190550
82Failure to thrive in infancy (HP:0001531)1.98779303
83Gaze-evoked nystagmus (HP:0000640)1.98690166
84Pheochromocytoma (HP:0002666)1.98365169
85Muscular hypotonia of the trunk (HP:0008936)1.98352016
86Large hands (HP:0001176)1.95544584
87Atrophy/Degeneration involving motor neurons (HP:0007373)1.95256754
88Pelvic girdle muscle weakness (HP:0003749)1.94258186
89Truncal ataxia (HP:0002078)1.93477906
90Decreased testicular size (HP:0008734)1.93235714
91Postaxial foot polydactyly (HP:0001830)1.90476548
92Hyperglycinuria (HP:0003108)1.90103187
93Abnormality of vitamin B metabolism (HP:0004340)1.89863102
94Prominent metopic ridge (HP:0005487)1.89611551
95Intestinal atresia (HP:0011100)1.89507261
96IgG deficiency (HP:0004315)1.89485582
97Abnormal activity of mitochondrial respiratory chain (HP:0011922)1.88847401
98Decreased activity of mitochondrial respiratory chain (HP:0008972)1.88847401
99Sensorimotor neuropathy (HP:0007141)1.88259302
100Poor eye contact (HP:0000817)1.88228232
101Gonadotropin excess (HP:0000837)1.87622771
102Pancreatic cysts (HP:0001737)1.87292309
103Autoamputation (HP:0001218)1.86811895
104Postaxial hand polydactyly (HP:0001162)1.85763322
105Muscle fiber atrophy (HP:0100295)1.84860606
106Fair hair (HP:0002286)1.84396822
107Generalized tonic-clonic seizures (HP:0002069)1.84148164
108Breast carcinoma (HP:0003002)1.83327011
109Aplasia/Hypoplasia of the tongue (HP:0010295)1.82548487
110Spinal cord lesions (HP:0100561)1.81127542
111Syringomyelia (HP:0003396)1.81127542
112Progressive macrocephaly (HP:0004481)1.80592147
113Poor coordination (HP:0002370)1.80481881
114Ketoacidosis (HP:0001993)1.80399130
115Ependymoma (HP:0002888)1.79211526
116Orthostatic hypotension (HP:0001278)1.77759963
117Abnormal glycosylation (HP:0012345)1.77606819
118Abnormal isoelectric focusing of serum transferrin (HP:0003160)1.77606819
119Abnormal protein N-linked glycosylation (HP:0012347)1.77606819
120Abnormal protein glycosylation (HP:0012346)1.77606819
121Generalized hypopigmentation of hair (HP:0011358)1.77243432
122Biliary tract neoplasm (HP:0100574)1.76628250
123Abnormality of the vitamin B12 metabolism (HP:0004341)1.75786513
124CNS hypomyelination (HP:0003429)1.75640904
125Acute necrotizing encephalopathy (HP:0006965)1.74631874
126Abnormality of the pancreatic islet cells (HP:0006476)1.74056176
127Abnormality of endocrine pancreas physiology (HP:0012093)1.74056176
128Abnormality of aspartate family amino acid metabolism (HP:0010899)1.73479903
129Intention tremor (HP:0002080)1.73392729
130Papilledema (HP:0001085)1.73216372
131Increased CSF lactate (HP:0002490)1.73184521
132Absent speech (HP:0001344)1.72892626
133Mediastinal lymphadenopathy (HP:0100721)1.72857197
134IgM deficiency (HP:0002850)1.72714062
135Rhabdomyosarcoma (HP:0002859)1.71614652
136Glioma (HP:0009733)1.71085828
137Oligomenorrhea (HP:0000876)1.70089962
138Acute encephalopathy (HP:0006846)1.69564382
139Renal hypoplasia (HP:0000089)1.69428072
140Ovarian neoplasm (HP:0100615)1.69276133
141Mutism (HP:0002300)1.69175794
142Abnormality of glycolysis (HP:0004366)1.68561273
143Increased serum pyruvate (HP:0003542)1.68561273
144Osteomyelitis (HP:0002754)1.67531842
145Myelodysplasia (HP:0002863)1.65068092
146Anteriorly placed anus (HP:0001545)1.64258451
147Downturned corners of mouth (HP:0002714)1.63098885
148Aplastic anemia (HP:0001915)1.62484141
149Thrombocytosis (HP:0001894)1.61741190
150Myositis (HP:0100614)1.61377249
151Progressive cerebellar ataxia (HP:0002073)1.60311378
152Stereotypic behavior (HP:0000733)1.58937696
153Broad foot (HP:0001769)1.58686764
154Labial hypoplasia (HP:0000066)1.57530826
155Septate vagina (HP:0001153)1.57162823
156Epileptiform EEG discharges (HP:0011182)1.57096328
157Impaired pain sensation (HP:0007328)1.56826364
158Abnormality of pain sensation (HP:0010832)1.56826364
159Inappropriate behavior (HP:0000719)1.56636886
160Pulmonary fibrosis (HP:0002206)1.55556736
161Amaurosis fugax (HP:0100576)1.54721098
162Abnormality of the nasal septum (HP:0000419)1.54617698
163Postnatal microcephaly (HP:0005484)1.54321819
164Abnormality of salivation (HP:0100755)1.53113991
165Muscle fibrillation (HP:0010546)1.53109611
166Eczematoid dermatitis (HP:0000976)1.51127619
167Abnormal mitochondria in muscle tissue (HP:0008316)1.50992141
168Freckling (HP:0001480)1.49884006
169Optic neuritis (HP:0100653)1.49832524
170Retrobulbar optic neuritis (HP:0100654)1.49832524
171Inability to walk (HP:0002540)1.49401682
172Upper motor neuron abnormality (HP:0002127)1.49146009
173Specific learning disability (HP:0001328)1.48485921
174Panhypogammaglobulinemia (HP:0003139)1.47679000
175Thin upper lip vermilion (HP:0000219)1.46555951

Predicted kinase interactions (KEA)

RankGene SetZ-score
1CASK4.89897204
2MAP4K24.45527710
3MAP3K124.26394536
4TRIM284.19423311
5TSSK63.58891219
6WNK33.16836286
7AKT33.11590420
8CDK192.94412190
9PLK22.90488525
10DAPK12.87554585
11CCNB12.85589490
12SIK32.67985951
13MAP2K72.47093996
14PRPF4B2.28110771
15EIF2AK12.20060971
16MKNK22.09887730
17CDK82.09616250
18MKNK12.04396432
19CSNK1G32.04307949
20YES12.01645287
21ERBB31.96155388
22BCKDK1.88810682
23CSNK1G21.85566798
24TIE11.85053318
25BUB11.83949317
26CSNK1G11.83438772
27CSNK1A1L1.71760414
28MAP3K41.67939271
29NTRK31.63750472
30RPS6KA41.60497250
31FRK1.59858994
32EPHA31.55520043
33EPHA41.50098530
34BRD41.46357214
35SGK21.36013979
36RIPK41.34367094
37PBK1.33833455
38PLK31.33550820
39DYRK31.31246018
40CDC71.30887352
41CAMKK21.30340403
42TXK1.28893141
43MAP3K51.17770314
44NEK11.16844880
45TNIK1.12425916
46TRPM71.12038104
47PDK21.03886051
48MARK11.02551892
49NUAK11.01674010
50TESK11.01025864
51FER1.00763928
52MINK10.99933231
53TTK0.96211288
54PINK10.89134053
55DAPK20.88578882
56TEC0.87662054
57BRSK10.86448848
58MATK0.85975951
59BMPR1B0.83767875
60SGK30.82492129
61STK38L0.81977829
62UHMK10.81196147
63MAP3K60.76983973
64MAP2K40.76977781
65SGK4940.76527893
66SGK2230.76527893
67PRKCG0.76177571
68ACVR1B0.73722791
69OXSR10.70544876
70TAOK20.70283886
71SCYL20.69470455
72CDK180.69082312
73SRPK10.68561271
74MST40.67974857
75STK160.66909189
76KSR10.66103069
77SYK0.65803409
78DYRK20.65200660
79PAK30.64534021
80EIF2AK20.64410663
81TGFBR10.63929475
82ADRBK20.61986474
83PAK60.61955719
84TESK20.61760851
85IRAK40.60245539
86KIT0.60129141
87RPS6KB10.59929825
88MAP3K140.59602414
89BRSK20.57803588
90ZAK0.56368689
91BMPR20.55642129
92FGFR10.55499881
93DYRK1A0.55335696
94WEE10.54946614
95CDK140.54131646
96ADRBK10.53052579
97CDK60.52999053
98CDK150.52275038
99FGFR20.52131302
100EIF2AK30.50950188
101LYN0.48803111
102ATR0.48166618
103VRK10.48073425
104CDK11A0.47448244
105CLK10.47296662
106RPS6KA60.47065440
107PIM20.45624228
108MYLK0.45494232
109BRAF0.43380634
110GRK50.42811484
111PRKCE0.41109914
112NEK90.39323405
113GRK60.38755719
114ALK0.37923073
115PLK10.37601947
116RAF10.37169056
117CAMK40.37101769
118BCR0.36984565
119LIMK10.36121914
120CAMKK10.35751053
121CDK50.35502587
122FGR0.33525315
123CAMK2B0.33438055
124ATM0.32902126
125CAMK2A0.32820128
126GRK70.32157821
127NEK60.32059210
128FES0.31584083
129MAPK130.30572864
130RPS6KC10.30232431
131RPS6KL10.30232431
132PLK40.29346880
133EGFR0.29291440
134CSNK1D0.29200711
135CSNK2A10.29168361
136PRKACB0.29090056
137ARAF0.29060390
138DDR20.28291096
139CSNK1A10.26869630
140CAMK2D0.26358681
141DYRK1B0.26129556
142LMTK20.23565161

Predicted pathways (KEGG)

RankGene SetZ-score
1Protein export_Homo sapiens_hsa030603.86457889
2Terpenoid backbone biosynthesis_Homo sapiens_hsa009003.66857936
3Synthesis and degradation of ketone bodies_Homo sapiens_hsa000723.32831176
4Steroid biosynthesis_Homo sapiens_hsa001003.18165064
5Synaptic vesicle cycle_Homo sapiens_hsa047212.95907467
6Non-homologous end-joining_Homo sapiens_hsa034502.86161264
7Propanoate metabolism_Homo sapiens_hsa006402.60948219
8Fatty acid elongation_Homo sapiens_hsa000622.60090197
9Collecting duct acid secretion_Homo sapiens_hsa049662.56322803
10Nicotine addiction_Homo sapiens_hsa050332.48483870
11Valine, leucine and isoleucine degradation_Homo sapiens_hsa002802.47140966
12Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005632.25891648
13Base excision repair_Homo sapiens_hsa034102.21728838
14Butanoate metabolism_Homo sapiens_hsa006502.13321742
15DNA replication_Homo sapiens_hsa030301.94314942
16Vibrio cholerae infection_Homo sapiens_hsa051101.82087168
17Spliceosome_Homo sapiens_hsa030401.78531958
18Mismatch repair_Homo sapiens_hsa034301.76618233
19Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa051201.75446025
20Olfactory transduction_Homo sapiens_hsa047401.72302579
21Rheumatoid arthritis_Homo sapiens_hsa053231.70736362
22Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010401.69816213
23Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006041.67672040
24Retrograde endocannabinoid signaling_Homo sapiens_hsa047231.66829466
252-Oxocarboxylic acid metabolism_Homo sapiens_hsa012101.63819905
26Long-term potentiation_Homo sapiens_hsa047201.63341473
27Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006301.61951193
28Proteasome_Homo sapiens_hsa030501.58418478
29Morphine addiction_Homo sapiens_hsa050321.58058991
30Amphetamine addiction_Homo sapiens_hsa050311.53928307
31GABAergic synapse_Homo sapiens_hsa047271.50613552
32Peroxisome_Homo sapiens_hsa041461.48878630
33Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030081.48410537
34Citrate cycle (TCA cycle)_Homo sapiens_hsa000201.47905209
35Circadian entrainment_Homo sapiens_hsa047131.46164595
36Type I diabetes mellitus_Homo sapiens_hsa049401.42297849
37Phagosome_Homo sapiens_hsa041451.41626342
38Regulation of autophagy_Homo sapiens_hsa041401.39912133
39Fatty acid metabolism_Homo sapiens_hsa012121.39851090
40Dopaminergic synapse_Homo sapiens_hsa047281.36531329
41Pantothenate and CoA biosynthesis_Homo sapiens_hsa007701.32536596
42Cell cycle_Homo sapiens_hsa041101.32273652
43beta-Alanine metabolism_Homo sapiens_hsa004101.28093937
44Taurine and hypotaurine metabolism_Homo sapiens_hsa004301.26081633
45Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004001.23974241
46Carbon metabolism_Homo sapiens_hsa012001.22923883
47Legionellosis_Homo sapiens_hsa051341.19709648
48Cysteine and methionine metabolism_Homo sapiens_hsa002701.17470882
49SNARE interactions in vesicular transport_Homo sapiens_hsa041301.15455685
50Nucleotide excision repair_Homo sapiens_hsa034201.14492990
51Oocyte meiosis_Homo sapiens_hsa041141.07877015
52Fanconi anemia pathway_Homo sapiens_hsa034601.06129376
53Colorectal cancer_Homo sapiens_hsa052101.04978666
54mRNA surveillance pathway_Homo sapiens_hsa030151.04935733
55Pyruvate metabolism_Homo sapiens_hsa006201.04711730
56RNA transport_Homo sapiens_hsa030131.04402660
57Glycine, serine and threonine metabolism_Homo sapiens_hsa002601.03403355
58Long-term depression_Homo sapiens_hsa047301.02312833
59Glycolysis / Gluconeogenesis_Homo sapiens_hsa000101.02298313
60Sulfur metabolism_Homo sapiens_hsa009201.02046722
61Shigellosis_Homo sapiens_hsa051311.00922001
62Parkinsons disease_Homo sapiens_hsa050120.98589665
63Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001300.97808467
64Oxidative phosphorylation_Homo sapiens_hsa001900.97370474
65Folate biosynthesis_Homo sapiens_hsa007900.96954100
66Pathogenic Escherichia coli infection_Homo sapiens_hsa051300.93535865
67Tuberculosis_Homo sapiens_hsa051520.91591703
68Primary immunodeficiency_Homo sapiens_hsa053400.91035673
69Epstein-Barr virus infection_Homo sapiens_hsa051690.90956555
70Glutamatergic synapse_Homo sapiens_hsa047240.90084473
71Serotonergic synapse_Homo sapiens_hsa047260.88224670
72RNA degradation_Homo sapiens_hsa030180.87926324
73Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa009700.87815468
74Biosynthesis of amino acids_Homo sapiens_hsa012300.87156154
75RNA polymerase_Homo sapiens_hsa030200.86989494
76Selenocompound metabolism_Homo sapiens_hsa004500.84996811
77Natural killer cell mediated cytotoxicity_Homo sapiens_hsa046500.84629589
78Intestinal immune network for IgA production_Homo sapiens_hsa046720.82111741
79Cholinergic synapse_Homo sapiens_hsa047250.81271802
80Taste transduction_Homo sapiens_hsa047420.80785780
81Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa047500.78980592
82Glioma_Homo sapiens_hsa052140.78271607
83Neuroactive ligand-receptor interaction_Homo sapiens_hsa040800.78228796
84Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002500.77789509
85Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006030.77102666
86Hepatitis B_Homo sapiens_hsa051610.76303024
87Antigen processing and presentation_Homo sapiens_hsa046120.75640365
88Fatty acid degradation_Homo sapiens_hsa000710.73563075
89Amyotrophic lateral sclerosis (ALS)_Homo sapiens_hsa050140.73037327
90Circadian rhythm_Homo sapiens_hsa047100.70721723
91Leishmaniasis_Homo sapiens_hsa051400.69954567
92Oxytocin signaling pathway_Homo sapiens_hsa049210.69374847
93Progesterone-mediated oocyte maturation_Homo sapiens_hsa049140.69221050
94Measles_Homo sapiens_hsa051620.69065175
95ErbB signaling pathway_Homo sapiens_hsa040120.68453816
96Phototransduction_Homo sapiens_hsa047440.66911735
97Protein processing in endoplasmic reticulum_Homo sapiens_hsa041410.66706232
98Neurotrophin signaling pathway_Homo sapiens_hsa047220.66693568
99Fc gamma R-mediated phagocytosis_Homo sapiens_hsa046660.66441726
100HIF-1 signaling pathway_Homo sapiens_hsa040660.66261719
101Basal transcription factors_Homo sapiens_hsa030220.65728784
102Calcium signaling pathway_Homo sapiens_hsa040200.65359573
103Purine metabolism_Homo sapiens_hsa002300.64645993
104Chemokine signaling pathway_Homo sapiens_hsa040620.64160274
105Transcriptional misregulation in cancer_Homo sapiens_hsa052020.64119802
106Allograft rejection_Homo sapiens_hsa053300.64110419
107Homologous recombination_Homo sapiens_hsa034400.64109228
108Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006010.64081091
109Chagas disease (American trypanosomiasis)_Homo sapiens_hsa051420.63370171
110Bacterial invasion of epithelial cells_Homo sapiens_hsa051000.62267834
111mTOR signaling pathway_Homo sapiens_hsa041500.62171814
112Pyrimidine metabolism_Homo sapiens_hsa002400.62107808
113Tryptophan metabolism_Homo sapiens_hsa003800.61106431
114Cytosolic DNA-sensing pathway_Homo sapiens_hsa046230.60950643
115Pancreatic cancer_Homo sapiens_hsa052120.60647593
116Herpes simplex infection_Homo sapiens_hsa051680.59560175
117Salmonella infection_Homo sapiens_hsa051320.58968411
118MAPK signaling pathway_Homo sapiens_hsa040100.58334261
119Metabolic pathways_Homo sapiens_hsa011000.58111703
120Glutathione metabolism_Homo sapiens_hsa004800.56340336
121Arginine and proline metabolism_Homo sapiens_hsa003300.56074394
122Renin secretion_Homo sapiens_hsa049240.55189030
123Gap junction_Homo sapiens_hsa045400.55102563
124Alcoholism_Homo sapiens_hsa050340.54881401
125Insulin secretion_Homo sapiens_hsa049110.54305499
126Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007600.53912439
127Viral carcinogenesis_Homo sapiens_hsa052030.53688836
128Fc epsilon RI signaling pathway_Homo sapiens_hsa046640.53556142
129B cell receptor signaling pathway_Homo sapiens_hsa046620.52747476
130Adrenergic signaling in cardiomyocytes_Homo sapiens_hsa042610.52687517
131Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa005200.51680082
132Ubiquitin mediated proteolysis_Homo sapiens_hsa041200.51622830
133RIG-I-like receptor signaling pathway_Homo sapiens_hsa046220.51346360
134Primary bile acid biosynthesis_Homo sapiens_hsa001200.51286140
135Aldosterone synthesis and secretion_Homo sapiens_hsa049250.50681705
136Influenza A_Homo sapiens_hsa051640.48670398
137Pertussis_Homo sapiens_hsa051330.48530348
138Melanoma_Homo sapiens_hsa052180.47427525
139N-Glycan biosynthesis_Homo sapiens_hsa005100.47130602
140p53 signaling pathway_Homo sapiens_hsa041150.46886134
141African trypanosomiasis_Homo sapiens_hsa051430.46147445
142Vasopressin-regulated water reabsorption_Homo sapiens_hsa049620.45636818
143Autoimmune thyroid disease_Homo sapiens_hsa053200.44340649
144Toll-like receptor signaling pathway_Homo sapiens_hsa046200.44280324
145Osteoclast differentiation_Homo sapiens_hsa043800.42279175
146Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate_Homo sapiens_hsa005320.41998188
147Cocaine addiction_Homo sapiens_hsa050300.41078241
148Non-small cell lung cancer_Homo sapiens_hsa052230.41042322
149Butirosin and neomycin biosynthesis_Homo sapiens_hsa005240.38517112
150Ether lipid metabolism_Homo sapiens_hsa005650.35282263
151Alzheimers disease_Homo sapiens_hsa050100.34331623
152Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005120.34126167
153Nitrogen metabolism_Homo sapiens_hsa009100.33841489
154Huntingtons disease_Homo sapiens_hsa050160.30696515
155Lysosome_Homo sapiens_hsa041420.29738347
156Sphingolipid metabolism_Homo sapiens_hsa006000.23894872
157Maturity onset diabetes of the young_Homo sapiens_hsa049500.22696238

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