HNRNPH3

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: This gene belongs to the subfamily of ubiquitously expressed heterogeneous nuclear ribonucleoproteins (hnRNPs). The hnRNPs are RNA binding proteins and they complex with heterogeneous nuclear RNA (hnRNA). These proteins are associated with pre-mRNAs in the nucleus and appear to influence pre-mRNA processing and other aspects of mRNA metabolism and transport. While all of the hnRNPs are present in the nucleus, some seem to shuttle between the nucleus and the cytoplasm. The hnRNP proteins have distinct nucleic acid binding properties. The protein encoded by this gene has two repeats of quasi-RRM domains that bind to RNAs. It is localized in nuclear bodies of the nucleus. This protein is involved in the splicing process and it also participates in early heat shock-induced splicing arrest by transiently leaving the hnRNP complexes. Several alternatively spliced transcript variants have been noted for this gene, however, not all are fully characterized. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1negative regulation of mRNA splicing, via spliceosome (GO:0048025)4.15234763
2sister chromatid segregation (GO:0000819)3.90683749
3mitotic sister chromatid cohesion (GO:0007064)3.88591813
4microtubule depolymerization (GO:0007019)3.88219069
5protein localization to kinetochore (GO:0034501)3.87302651
6negative regulation of RNA splicing (GO:0033119)3.82624017
7mitotic sister chromatid segregation (GO:0000070)3.79202481
8mitotic chromosome condensation (GO:0007076)3.78360241
9negative regulation of mRNA processing (GO:0050686)3.76869484
10intra-S DNA damage checkpoint (GO:0031573)3.68926240
11CENP-A containing nucleosome assembly (GO:0034080)3.56741024
12DNA damage response, detection of DNA damage (GO:0042769)3.46813864
13regulation of rhodopsin mediated signaling pathway (GO:0022400)3.40117079
14formation of translation preinitiation complex (GO:0001731)3.37761035
15pre-miRNA processing (GO:0031054)3.36613145
16protein localization to chromosome, centromeric region (GO:0071459)3.36600762
17rhodopsin mediated signaling pathway (GO:0016056)3.28176819
18regulation of mRNA splicing, via spliceosome (GO:0048024)3.27483196
19establishment of viral latency (GO:0019043)3.27406263
20mRNA splice site selection (GO:0006376)3.24849332
21heterochromatin organization (GO:0070828)3.21820995
22regulation of alternative mRNA splicing, via spliceosome (GO:0000381)3.15371407
23histone H2A acetylation (GO:0043968)3.14564343
24regulation of RNA export from nucleus (GO:0046831)3.12046830
25nuclear pore complex assembly (GO:0051292)3.11424551
26spliceosomal complex assembly (GO:0000245)3.09916801
27DNA strand elongation involved in DNA replication (GO:0006271)3.07966140
28positive regulation of intracellular steroid hormone receptor signaling pathway (GO:0033145)3.03116508
29DNA topological change (GO:0006265)2.99379495
30negative regulation of mRNA metabolic process (GO:1903312)2.98746042
31positive regulation of gastrulation (GO:2000543)2.98561948
32DNA strand elongation (GO:0022616)2.97621229
33V(D)J recombination (GO:0033151)2.96891626
34centriole replication (GO:0007099)2.96584935
35* mRNA splicing, via spliceosome (GO:0000398)2.94273123
36* RNA splicing, via transesterification reactions with bulged adenosine as nucleophile (GO:0000377)2.94273123
37kinetochore assembly (GO:0051382)2.93779733
38mRNA stabilization (GO:0048255)2.92945104
39RNA stabilization (GO:0043489)2.92945104
40nuclear pore organization (GO:0006999)2.92778143
41paraxial mesoderm development (GO:0048339)2.91456790
42nonmotile primary cilium assembly (GO:0035058)2.90734902
43* RNA splicing, via transesterification reactions (GO:0000375)2.89789866
44kinetochore organization (GO:0051383)2.89725950
45negative regulation of DNA recombination (GO:0045910)2.88941150
46pyrimidine nucleobase catabolic process (GO:0006208)2.87973574
47histone H2B ubiquitination (GO:0033523)2.87135414
48spindle checkpoint (GO:0031577)2.84577881
49protein-DNA complex disassembly (GO:0032986)2.84157708
50nucleosome disassembly (GO:0006337)2.84157708
51mitotic spindle checkpoint (GO:0071174)2.82204551
52telomere maintenance via semi-conservative replication (GO:0032201)2.81022190
53retinal cone cell development (GO:0046549)2.81011945
54termination of RNA polymerase II transcription (GO:0006369)2.80943249
55DNA replication checkpoint (GO:0000076)2.80766192
56regulation of mRNA stability (GO:0043488)2.80479447
57photoreceptor cell development (GO:0042461)2.79801239
58establishment of chromosome localization (GO:0051303)2.77071493
59regulation of attachment of spindle microtubules to kinetochore (GO:0051988)2.76028575
60DNA unwinding involved in DNA replication (GO:0006268)2.74079025
61ncRNA catabolic process (GO:0034661)2.73852682
62eye photoreceptor cell development (GO:0042462)2.72055101
63protein localization to chromosome (GO:0034502)2.71636797
64regulation of helicase activity (GO:0051095)2.71428995
65regulation of single stranded viral RNA replication via double stranded DNA intermediate (GO:00450912.71066903
66regulation of chromosome segregation (GO:0051983)2.70702167
67attachment of spindle microtubules to kinetochore (GO:0008608)2.70614829
68IMP biosynthetic process (GO:0006188)2.69939081
69ribonucleoprotein complex assembly (GO:0022618)2.69719779
70mRNA transport (GO:0051028)2.66720595
71regulation of sister chromatid segregation (GO:0033045)2.66140095
72regulation of mitotic sister chromatid separation (GO:0010965)2.66140095
73regulation of mitotic sister chromatid segregation (GO:0033047)2.66140095
74spliceosomal tri-snRNP complex assembly (GO:0000244)2.65759656
75regulation of mitotic metaphase/anaphase transition (GO:0030071)2.63809831
76regulation of metaphase/anaphase transition of cell cycle (GO:1902099)2.63809831
77ribonucleoprotein complex subunit organization (GO:0071826)2.63515421
78mitotic recombination (GO:0006312)2.63331741
79viral mRNA export from host cell nucleus (GO:0046784)2.63055171
80photoreceptor cell maintenance (GO:0045494)2.62738569
81ATP-dependent chromatin remodeling (GO:0043044)2.62294197
82intraciliary transport (GO:0042073)2.60625311
83regulation of mRNA processing (GO:0050684)2.60342982
84DNA double-strand break processing (GO:0000729)2.58996286
85L-serine metabolic process (GO:0006563)2.58729529
86presynaptic membrane assembly (GO:0097105)2.58689529
87regulation of DNA endoreduplication (GO:0032875)2.57298188
88regulation of development, heterochronic (GO:0040034)2.57245708
89regulation of RNA splicing (GO:0043484)2.57119670
90planar cell polarity pathway involved in neural tube closure (GO:0090179)2.56798771
91mitotic spindle organization (GO:0007052)2.56576170
92regulation of RNA stability (GO:0043487)2.56494791
93cell proliferation in forebrain (GO:0021846)2.56021409
94regulation of DNA damage checkpoint (GO:2000001)2.54990073
95* RNA splicing (GO:0008380)2.54199455
96DNA replication-dependent nucleosome assembly (GO:0006335)2.53741502
97DNA replication-dependent nucleosome organization (GO:0034723)2.53741502
98primitive streak formation (GO:0090009)2.53306682
99alternative mRNA splicing, via spliceosome (GO:0000380)2.50566789
100regulation of establishment of planar polarity involved in neural tube closure (GO:0090178)2.50566284
101spliceosomal snRNP assembly (GO:0000387)2.48127990
102DNA replication-independent nucleosome assembly (GO:0006336)2.45884956
103DNA replication-independent nucleosome organization (GO:0034724)2.45884956
104urogenital system development (GO:0001655)2.44757536
105exonucleolytic nuclear-transcribed mRNA catabolic process involved in deadenylation-dependent decay 2.44630336
106proximal/distal pattern formation (GO:0009954)2.42475472
107regulation of sister chromatid cohesion (GO:0007063)2.42310576
108mitotic metaphase plate congression (GO:0007080)2.42123148
109RNA export from nucleus (GO:0006405)2.41881210
110DNA strand renaturation (GO:0000733)2.41472084
111DNA ligation (GO:0006266)2.39958856
112mRNA export from nucleus (GO:0006406)2.39708362
113rRNA catabolic process (GO:0016075)2.38259745
114regulation of meiosis I (GO:0060631)2.37433679
115peptidyl-arginine methylation (GO:0018216)2.36991333
116peptidyl-arginine N-methylation (GO:0035246)2.36991333
117head development (GO:0060322)2.35975371
118histone exchange (GO:0043486)2.35224173
119negative regulation of mitotic metaphase/anaphase transition (GO:0045841)2.34918831
120negative regulation of sister chromatid segregation (GO:0033046)2.34918831
121negative regulation of mitotic sister chromatid separation (GO:2000816)2.34918831
122negative regulation of mitotic sister chromatid segregation (GO:0033048)2.34918831
123lateral sprouting from an epithelium (GO:0060601)2.33707770
124negative regulation of histone methylation (GO:0031061)2.33351299
125RNA localization (GO:0006403)2.32286682
126metaphase plate congression (GO:0051310)2.32085096
127somite development (GO:0061053)2.30373482
128negative regulation of chromosome segregation (GO:0051985)2.30099357
129mitotic spindle assembly checkpoint (GO:0007094)2.30072632
130regulation of non-canonical Wnt signaling pathway (GO:2000050)2.29909706
131positive regulation of RNA splicing (GO:0033120)2.29229794
132regulation of mRNA metabolic process (GO:1903311)2.29063439
133DNA integration (GO:0015074)2.28261837
134spindle assembly checkpoint (GO:0071173)2.27666850
135negative regulation of metaphase/anaphase transition of cell cycle (GO:1902100)2.27632487
136establishment of integrated proviral latency (GO:0075713)2.26737119
137nuclear-transcribed mRNA catabolic process, exonucleolytic (GO:0000291)2.25215858
138histone arginine methylation (GO:0034969)2.25178736
139cilium or flagellum-dependent cell motility (GO:0001539)2.24377594
140peptidyl-arginine omega-N-methylation (GO:0035247)2.24372552
141cell migration in hindbrain (GO:0021535)2.24279679
142positive regulation of histone H3-K4 methylation (GO:0051571)2.23584819
143sister chromatid cohesion (GO:0007062)2.23281453
144stress granule assembly (GO:0034063)2.20191748
145negative regulation of DNA-dependent DNA replication (GO:2000104)2.19985824
146retinal rod cell development (GO:0046548)2.19620444
147chromatin remodeling at centromere (GO:0031055)2.18555434
148centriole assembly (GO:0098534)2.18160068
149interkinetic nuclear migration (GO:0022027)2.18097147

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1E2F7_22180533_ChIP-Seq_HELA_Human6.18037352
2HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse3.70715375
3EZH2_22144423_ChIP-Seq_EOC_Human3.53232420
4TP63_19390658_ChIP-ChIP_HaCaT_Human3.41230954
5E2F4_17652178_ChIP-ChIP_JURKAT_Human3.01847074
6RBPJ_22232070_ChIP-Seq_NCS_Mouse3.01154390
7FOXM1_23109430_ChIP-Seq_U2OS_Human2.77652798
8CREB1_15753290_ChIP-ChIP_HEK293T_Human2.68258762
9HCFC1_20581084_ChIP-Seq_MESCs_Mouse2.60415567
10MYBL1_21750041_ChIP-ChIP_SPERMATOCYTES_Mouse2.58793374
11SALL1_21062744_ChIP-ChIP_HESCs_Human2.46745226
12FOXM1_25889361_ChIP-Seq_OE33_AND_U2OS_Human2.34694158
13MYCN_21190229_ChIP-Seq_SHEP-21N_Human2.20450896
14CBX2_27304074_Chip-Seq_ESCs_Mouse2.13597789
15MYC_18555785_ChIP-Seq_MESCs_Mouse2.11191598
16EKLF_21900194_ChIP-Seq_ERYTHROCYTE_Mouse2.11148406
17FUS_26573619_Chip-Seq_HEK293_Human2.02746035
18* KDM5B_21448134_ChIP-Seq_MESCs_Mouse1.99762966
19AR_21909140_ChIP-Seq_LNCAP_Human1.97486832
20POU5F1_16153702_ChIP-ChIP_HESCs_Human1.94717836
21E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse1.90635289
22YY1_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse1.88779149
23CIITA_25753668_ChIP-Seq_RAJI_Human1.85791920
24DMRT1_21621532_ChIP-ChIP_FETAL_Ovary1.81632511
25BMI1_23680149_ChIP-Seq_NPCS_Mouse1.73771763
26KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human1.73157104
27* TTF2_22483619_ChIP-Seq_HELA_Human1.71920516
28CDKN2AIP_20523734_ChIP-Seq_CORTICAL_Neurons1.70158073
29EST1_17652178_ChIP-ChIP_JURKAT_Human1.69814021
30CIITA_18437201_ChIP-ChIP_Raji_B_and_iDC_Human1.69351873
31GLI1_17442700_ChIP-ChIP_MESCs_Mouse1.66445467
32EZH2_27304074_Chip-Seq_ESCs_Mouse1.60956111
33* XRN2_22483619_ChIP-Seq_HELA_Human1.60732550
34SOX2_16153702_ChIP-ChIP_HESCs_Human1.54576301
35DCP1A_22483619_ChIP-Seq_HELA_Human1.53761167
36RNF2_27304074_Chip-Seq_NSC_Mouse1.50279276
37THAP11_20581084_ChIP-Seq_MESCs_Mouse1.45417882
38E2F1_21310950_ChIP-Seq_MCF-7_Human1.44767453
39EWS_26573619_Chip-Seq_HEK293_Human1.43369470
40SOX2_19030024_ChIP-ChIP_MESCs_Mouse1.43304116
41ZFP322A_24550733_ChIP-Seq_MESCs_Mouse1.42287904
42NANOG_18700969_ChIP-ChIP_MESCs_Mouse1.39864931
43E2F1_18555785_ChIP-Seq_MESCs_Mouse1.38801855
44ELF1_17652178_ChIP-ChIP_JURKAT_Human1.37945573
45CHD1_19587682_ChIP-ChIP_MESCs_Mouse1.37550380
46* HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human1.36915469
47PRDM5_23873026_ChIP-Seq_MEFs_Mouse1.35574311
48NANOG_21062744_ChIP-ChIP_HESCs_Human1.35444994
49MYC_19030024_ChIP-ChIP_MESCs_Mouse1.35037611
50PHC1_16625203_ChIP-ChIP_MESCs_Mouse1.34467668
51MYC_19079543_ChIP-ChIP_MESCs_Mouse1.33386991
52CCND1_20090754_ChIP-ChIP_RETINA_Mouse1.31402428
53MYBL2_22936984_ChIP-ChIP_MESCs_Mouse1.31148582
54SOX2_18555785_ChIP-Seq_MESCs_Mouse1.30852627
55ETS1_20019798_ChIP-Seq_JURKAT_Human1.30174447
56WT1_19549856_ChIP-ChIP_CCG9911_Human1.30115868
57ZNF274_21170338_ChIP-Seq_K562_Hela1.29752467
58GBX2_23144817_ChIP-Seq_PC3_Human1.26787859
59MYC_18940864_ChIP-ChIP_HL60_Human1.24151239
60GABP_17652178_ChIP-ChIP_JURKAT_Human1.21796014
61ZFP42_18358816_ChIP-ChIP_MESCs_Mouse1.21510362
62NANOG_18555785_ChIP-Seq_MESCs_Mouse1.20537368
63NR4A2_19515692_ChIP-ChIP_MN9D_Mouse1.20350965
64JARID2_20064375_ChIP-Seq_MESCs_Mouse1.18901877
65SALL4_18804426_ChIP-ChIP_MESCs_Mouse1.18670230
66PKCTHETA_26484144_Chip-Seq_BREAST_Human1.18034031
67PPARG_23326641_ChIP-Seq_C3H10T1-2_Mouse1.17017147
68KLF5_18264089_ChIP-ChIP_MESCs_Mouse1.16624263
69KLF4_18264089_ChIP-ChIP_MESCs_Mouse1.16624263
70KLF2_18264089_ChIP-ChIP_MESCs_Mouse1.16624263
71HOXD13_18407260_ChIP-ChIP_DEVELOPING-LIMBS_Mouse1.16544306
72SOX9_22984422_ChIP-ChIP_TESTIS_Rat1.14872118
73* E2F4_21247883_ChIP-Seq_LYMPHOBLASTOID_Human1.14417589
74MYC_18358816_ChIP-ChIP_MESCs_Mouse1.13893482
75KDM5A_27292631_Chip-Seq_BREAST_Human1.12525372
76JARID1A_20064375_ChIP-Seq_MESCs_Mouse1.11303325
77TAF15_26573619_Chip-Seq_HEK293_Human1.09890897
78POU3F2_20337985_ChIP-ChIP_501MEL_Human1.09541727
79POU5F1_18700969_ChIP-ChIP_MESCs_Mouse1.08667862
80* VDR_23849224_ChIP-Seq_CD4+_Human1.08387767
81* CREM_20920259_ChIP-Seq_GC1-SPG_Mouse1.07286414
82CTBP2_25329375_ChIP-Seq_LNCAP_Human1.06902392
83SOX9_26525672_Chip-Seq_HEART_Mouse1.05932200
84CEBPB_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.05766320
85IRF1_19129219_ChIP-ChIP_H3396_Human1.05215885
86RNF2_27304074_Chip-Seq_ESCs_Mouse1.05122937
87NOTCH1_17114293_ChIP-ChIP_T-ALL_Human1.05108770
88TRIM28_19339689_ChIP-ChIP_MESCs_Mouse1.04898799
89OLIG2_26023283_ChIP-Seq_AINV15_Mouse1.04493364
90SOX2_18358816_ChIP-ChIP_MESCs_Mouse1.04092506
91FOXO3_22982991_ChIP-Seq_MACROPHAGES_Mouse1.04058661
92KLF4_19030024_ChIP-ChIP_MESCs_Mouse1.03543215
93EGR1_19374776_ChIP-ChIP_THP-1_Human1.02402980
94NELFA_20434984_ChIP-Seq_ESCs_Mouse1.00522425
95POU5F1_18347094_ChIP-ChIP_MESCs_Mouse1.00029108
96MYCN_18555785_ChIP-Seq_MESCs_Mouse0.99963060
97TCF3_18467660_ChIP-ChIP_MESCs_Mouse0.99143955
98FOXP3_21729870_ChIP-Seq_TREG_Human0.97472163
99ELK1_19687146_ChIP-ChIP_HELA_Human0.96550495
100EED_16625203_ChIP-ChIP_MESCs_Mouse0.95190864
101CRX_20693478_ChIP-Seq_ADULT_RETINA_Mouse0.95183185
102ZFP281_18358816_ChIP-ChIP_MESCs_Mouse0.95062003
103GATA1_26923725_Chip-Seq_HPCs_Mouse0.94795563
104ZFP57_27257070_Chip-Seq_ESCs_Mouse0.94753542
105IGF1R_20145208_ChIP-Seq_DFB_Human0.94508090
106GABP_19822575_ChIP-Seq_HepG2_Human0.92904596
107JARID2_20075857_ChIP-Seq_MESCs_Mouse0.92369403
108FOXP2_21765815_ChIP-ChIP_NEURO2A_Mouse0.91817443
109REST_21632747_ChIP-Seq_MESCs_Mouse0.90463329
110POU5F1_18555785_ChIP-Seq_MESCs_Mouse0.90396813
111PADI4_21655091_ChIP-ChIP_MCF-7_Human0.90367775
112RNF2_16625203_ChIP-ChIP_MESCs_Mouse0.89962037
113ASH2L_23239880_ChIP-Seq_MESCs_Mouse0.89752081
114CHD1_26751641_Chip-Seq_LNCaP_Human0.88552017
115P300_19829295_ChIP-Seq_ESCs_Human0.87328701
116EZH2_27294783_Chip-Seq_ESCs_Mouse0.87268583
117SOX17_20123909_ChIP-Seq_XEN_Mouse0.87048391
118CREB1_20920259_ChIP-Seq_GC1-SPG_Mouse0.86933758
119TCF3_18692474_ChIP-Seq_MEFs_Mouse0.86792466
120NANOG_16153702_ChIP-ChIP_HESCs_Human0.86026455
121REST_19997604_ChIP-ChIP_NEURONS_Mouse0.85088478
122EP300_20729851_ChIP-Seq_FORBRAIN_MIDBRAIN_LIMB_HEART_Mouse0.85038810
123RING1B_27294783_Chip-Seq_NPCs_Mouse0.84840967
124CREB1_23762244_ChIP-Seq_HIPPOCAMPUS_Rat0.84315798
125POU5F1_18358816_ChIP-ChIP_MESCs_Mouse0.83964304
126ISL1_27105846_Chip-Seq_CPCs_Mouse0.83830872
127DMRT1_23473982_ChIP-Seq_TESTES_Mouse0.83245328
128SUZ12_16625203_ChIP-ChIP_MESCs_Mouse0.82572632
129PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human0.80749711
130PDX1_19855005_ChIP-ChIP_MIN6_Mouse0.80719463
131P53_22127205_ChIP-Seq_FIBROBLAST_Human0.80154255
132YY1_21170310_ChIP-Seq_MESCs_Mouse0.79814174
133ZFX_18555785_ChIP-Seq_MESCs_Mouse0.78833488

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0006292_abnormal_olfactory_placode3.68825612
2MP0003122_maternal_imprinting2.83087561
3MP0003121_genomic_imprinting2.43668546
4MP0006072_abnormal_retinal_apoptosis2.40516036
5MP0002653_abnormal_ependyma_morphology2.25878463
6MP0003880_abnormal_central_pattern2.24556799
7MP0003890_abnormal_embryonic-extraembry2.17926587
8MP0010030_abnormal_orbit_morphology2.10973195
9MP0002938_white_spotting2.10867718
10MP0005551_abnormal_eye_electrophysiolog2.09182057
11MP0003787_abnormal_imprinting2.08453329
12MP0008877_abnormal_DNA_methylation2.07184457
13MP0000049_abnormal_middle_ear2.04435569
14MP0010094_abnormal_chromosome_stability2.02541196
15MP0000566_synostosis1.99213576
16MP0008057_abnormal_DNA_replication1.99184785
17MP0002638_abnormal_pupillary_reflex1.98507409
18MP0003693_abnormal_embryo_hatching1.94645854
19MP0008058_abnormal_DNA_repair1.85863816
20MP0005253_abnormal_eye_physiology1.83270531
21MP0003123_paternal_imprinting1.81151835
22MP0004859_abnormal_synaptic_plasticity1.78894947
23MP0008789_abnormal_olfactory_epithelium1.73259216
24MP0000537_abnormal_urethra_morphology1.68932035
25MP0000778_abnormal_nervous_system1.66262588
26MP0003111_abnormal_nucleus_morphology1.64411593
27MP0003077_abnormal_cell_cycle1.62227158
28MP0001730_embryonic_growth_arrest1.61311646
29MP0000631_abnormal_neuroendocrine_gland1.59976919
30MP0004197_abnormal_fetal_growth/weight/1.51562744
31MP0003315_abnormal_perineum_morphology1.46385986
32MP0005394_taste/olfaction_phenotype1.44750328
33MP0005499_abnormal_olfactory_system1.44750328
34MP0003119_abnormal_digestive_system1.44635526
35MP0001188_hyperpigmentation1.44512726
36MP0003385_abnormal_body_wall1.43001068
37MP0003221_abnormal_cardiomyocyte_apopto1.42848098
38MP0000350_abnormal_cell_proliferation1.41805105
39MP0003011_delayed_dark_adaptation1.39406004
40MP0005409_darkened_coat_color1.37166405
41MP0008932_abnormal_embryonic_tissue1.35405816
42MP0002249_abnormal_larynx_morphology1.35041363
43MP0001697_abnormal_embryo_size1.33347626
44MP0002751_abnormal_autonomic_nervous1.33035864
45MP0003937_abnormal_limbs/digits/tail_de1.32862892
46MP0002102_abnormal_ear_morphology1.31177748
47MP0005380_embryogenesis_phenotype1.26976232
48MP0005391_vision/eye_phenotype1.26389914
49MP0001293_anophthalmia1.26241829
50MP0003942_abnormal_urinary_system1.24245151
51MP0002163_abnormal_gland_morphology1.23139470
52MP0005187_abnormal_penis_morphology1.23053823
53MP0003935_abnormal_craniofacial_develop1.22719724
54MP0003861_abnormal_nervous_system1.22391078
55MP0004957_abnormal_blastocyst_morpholog1.21960711
56MP0003938_abnormal_ear_development1.21691303
57MP0001299_abnormal_eye_distance/1.21541412
58MP0006276_abnormal_autonomic_nervous1.20626657
59MP0001984_abnormal_olfaction1.20532941
60MP0008007_abnormal_cellular_replicative1.20179232
61MP0002009_preneoplasia1.19263007
62MP0000955_abnormal_spinal_cord1.17284944
63MP0002092_abnormal_eye_morphology1.16580473
64MP0005423_abnormal_somatic_nervous1.15727709
65MP0001286_abnormal_eye_development1.15309579
66MP0004811_abnormal_neuron_physiology1.14928967
67MP0002234_abnormal_pharynx_morphology1.11321035
68MP0003984_embryonic_growth_retardation1.11301402
69MP0002210_abnormal_sex_determination1.10938415
70MP0009672_abnormal_birth_weight1.10647377
71MP0001270_distended_abdomen1.10339990
72MP0004133_heterotaxia1.10310886
73MP0002111_abnormal_tail_morphology1.10271887
74MP0005248_abnormal_Harderian_gland1.10113438
75MP0003755_abnormal_palate_morphology1.08453796
76MP0002080_prenatal_lethality1.08250260
77MP0002752_abnormal_somatic_nervous1.08051390
78MP0002088_abnormal_embryonic_growth/wei1.07394727
79MP0002116_abnormal_craniofacial_bone1.07071313
80MP0005195_abnormal_posterior_eye1.05920966
81MP0001529_abnormal_vocalization1.05505374
82MP0002085_abnormal_embryonic_tissue1.03794559
83MP0002084_abnormal_developmental_patter1.02863427
84MP0002557_abnormal_social/conspecific_i1.02743064
85MP0002177_abnormal_outer_ear1.01126680
86MP0000678_abnormal_parathyroid_gland1.01060099
87MP0001485_abnormal_pinna_reflex1.00470630
88MP0005379_endocrine/exocrine_gland_phen0.99182451
89MP0008995_early_reproductive_senescence0.98849572
90MP0003567_abnormal_fetal_cardiomyocyte0.98737216
91MP0002184_abnormal_innervation0.98232400
92MP0003136_yellow_coat_color0.98229527
93MP0001346_abnormal_lacrimal_gland0.97098673
94MP0000026_abnormal_inner_ear0.96955263
95MP0009053_abnormal_anal_canal0.95552267
96MP0001486_abnormal_startle_reflex0.95541784
97MP0009250_abnormal_appendicular_skeleto0.93894669
98MP0004270_analgesia0.93852197
99MP0001177_atelectasis0.93658158
100MP0002233_abnormal_nose_morphology0.93203793
101MP0000428_abnormal_craniofacial_morphol0.92943070
102MP0002882_abnormal_neuron_morphology0.92270173
103MP0002152_abnormal_brain_morphology0.91027458
104MP0009703_decreased_birth_body0.90486184
105MP0004885_abnormal_endolymph0.89037966
106MP0002877_abnormal_melanocyte_morpholog0.87941617
107MP0002277_abnormal_respiratory_mucosa0.84736225
108MP0003718_maternal_effect0.84585840
109MP0002127_abnormal_cardiovascular_syste0.83882456
110MP0000534_abnormal_ureter_morphology0.83710699
111MP0005646_abnormal_pituitary_gland0.83695643
112MP0003698_abnormal_male_reproductive0.82427804
113MP0005645_abnormal_hypothalamus_physiol0.82320011
114MP0001929_abnormal_gametogenesis0.82163683
115MP0002081_perinatal_lethality0.81777441
116MP0001145_abnormal_male_reproductive0.81329690
117MP0002697_abnormal_eye_size0.80420084
118MP0003115_abnormal_respiratory_system0.79814897
119MP0002063_abnormal_learning/memory/cond0.79534934
120MP0002932_abnormal_joint_morphology0.79515998
121MP0000313_abnormal_cell_death0.79499329
122MP0002114_abnormal_axial_skeleton0.77779166
123MP0002160_abnormal_reproductive_system0.76499203
124MP0000653_abnormal_sex_gland0.75947536
125MP0001672_abnormal_embryogenesis/_devel0.75712145
126MP0003635_abnormal_synaptic_transmissio0.75635198
127MP0001502_abnormal_circadian_rhythm0.75119577

Predicted human phenotypes

RankGene SetZ-score
1Cortical dysplasia (HP:0002539)4.22274184
2Congenital stationary night blindness (HP:0007642)3.75434914
3Pendular nystagmus (HP:0012043)3.68255985
4Volvulus (HP:0002580)3.31491428
5Chromosomal breakage induced by crosslinking agents (HP:0003221)3.26048472
6Medulloblastoma (HP:0002885)3.14235127
7Chromsome breakage (HP:0040012)3.08721380
8Bony spicule pigmentary retinopathy (HP:0007737)3.05800024
9Absent rod-and cone-mediated responses on ERG (HP:0007688)2.96794126
10Abnormal rod and cone electroretinograms (HP:0008323)2.87444101
11Severe visual impairment (HP:0001141)2.71942948
12Hepatoblastoma (HP:0002884)2.69595031
13Colon cancer (HP:0003003)2.64615679
14Attenuation of retinal blood vessels (HP:0007843)2.61536064
15Meckel diverticulum (HP:0002245)2.59300624
16Abnormal number of incisors (HP:0011064)2.56775875
17Aplasia/Hypoplasia of the uvula (HP:0010293)2.55380141
18Increased nuchal translucency (HP:0010880)2.48834680
19Abnormality of the ileum (HP:0001549)2.48062467
20Renal duplication (HP:0000075)2.44443231
21Chorioretinal atrophy (HP:0000533)2.42370378
22Shoulder girdle muscle weakness (HP:0003547)2.39398149
23Abnormality of the preputium (HP:0100587)2.36647306
24Dyschromatopsia (HP:0007641)2.33366263
25Gait imbalance (HP:0002141)2.32244044
26Nephroblastoma (Wilms tumor) (HP:0002667)2.32214515
27Congenital primary aphakia (HP:0007707)2.31994890
28Medial flaring of the eyebrow (HP:0010747)2.31313816
29Decreased central vision (HP:0007663)2.27352256
30Patellar aplasia (HP:0006443)2.23932032
31Short 4th metacarpal (HP:0010044)2.21670677
32Aplasia/Hypoplasia of the 4th metacarpal (HP:0010042)2.21670677
33Abnormality of the septum pellucidum (HP:0007375)2.21165968
34Midline defect of the nose (HP:0004122)2.17585085
35Bifid tongue (HP:0010297)2.17517721
36Embryonal renal neoplasm (HP:0011794)2.15787874
37Abnormality of the labia minora (HP:0012880)2.13486749
38Aplasia/Hypoplasia of the patella (HP:0006498)2.13295346
39Nephrogenic diabetes insipidus (HP:0009806)2.13171634
40Drooling (HP:0002307)2.12995740
41Trigonocephaly (HP:0000243)2.12377850
42Absent septum pellucidum (HP:0001331)2.12013984
43Acute lymphatic leukemia (HP:0006721)2.05901433
44Ectopic kidney (HP:0000086)2.02695515
45Abnormality of the musculature of the pelvis (HP:0001469)2.01471731
46Abnormality of the hip-girdle musculature (HP:0001445)2.01471731
47Type II diabetes mellitus (HP:0005978)2.01060570
48Abnormality of midbrain morphology (HP:0002418)2.00390776
49Molar tooth sign on MRI (HP:0002419)2.00390776
50Abnormality of the carotid arteries (HP:0005344)1.99655611
51Morphological abnormality of the middle ear (HP:0008609)1.99219163
52Coarctation of aorta (HP:0001680)1.97637774
53Abnormal lung lobation (HP:0002101)1.97339571
54Calcaneovalgus deformity (HP:0001848)1.95935421
55Oligodactyly (hands) (HP:0001180)1.95775952
56Pancreatic fibrosis (HP:0100732)1.93126866
57Birth length less than 3rd percentile (HP:0003561)1.92439863
58Long eyelashes (HP:0000527)1.91262812
59Pelvic girdle muscle weakness (HP:0003749)1.91106217
60Supernumerary spleens (HP:0009799)1.90817755
61Vaginal atresia (HP:0000148)1.90397079
62Aplastic anemia (HP:0001915)1.90323023
63Septo-optic dysplasia (HP:0100842)1.89825386
64Excessive salivation (HP:0003781)1.89744361
65Hemivertebrae (HP:0002937)1.89255061
66Optic nerve coloboma (HP:0000588)1.89090878
67Duodenal stenosis (HP:0100867)1.88707018
68Small intestinal stenosis (HP:0012848)1.88707018
69Reticulocytopenia (HP:0001896)1.87772941
70Genital tract atresia (HP:0001827)1.86660523
71Pancreatic cysts (HP:0001737)1.84171339
72Abnormality of chromosome stability (HP:0003220)1.84087472
73Renal hypoplasia (HP:0000089)1.84057094
74Ependymoma (HP:0002888)1.83707458
75Central scotoma (HP:0000603)1.83355522
76Abnormality of the intervertebral disk (HP:0005108)1.83179782
77Hyperglycinemia (HP:0002154)1.82850153
78Proximal placement of thumb (HP:0009623)1.82522268
79Anal stenosis (HP:0002025)1.82455110
80Renal dysplasia (HP:0000110)1.81642986
81True hermaphroditism (HP:0010459)1.80829426
82Vertebral arch anomaly (HP:0008438)1.80380628
83Long clavicles (HP:0000890)1.79913887
84Horseshoe kidney (HP:0000085)1.79528029
85Rib fusion (HP:0000902)1.78845681
86Anophthalmia (HP:0000528)1.78796968
87Absent eyebrow (HP:0002223)1.77822870
88Multicystic kidney dysplasia (HP:0000003)1.77744123
89Rhabdomyosarcoma (HP:0002859)1.77550289
90Nephronophthisis (HP:0000090)1.77115202
91Triphalangeal thumb (HP:0001199)1.76660138
92Deformed tarsal bones (HP:0008119)1.75683038
93Abnormality of the parietal bone (HP:0002696)1.75579347
94Aplasia/Hypoplasia of the sternum (HP:0006714)1.75535560
95Supernumerary ribs (HP:0005815)1.75521018
96Keratoconus (HP:0000563)1.75314192
97Increased corneal curvature (HP:0100692)1.75314192
98Intestinal atresia (HP:0011100)1.75094474
99Aqueductal stenosis (HP:0002410)1.74361541
100Obsessive-compulsive behavior (HP:0000722)1.73628871
101Aganglionic megacolon (HP:0002251)1.73302596
102Broad foot (HP:0001769)1.73232342
103Omphalocele (HP:0001539)1.72199907
104Spastic diplegia (HP:0001264)1.71245548
105Abnormality of the fingertips (HP:0001211)1.71046307
106Hyperacusis (HP:0010780)1.69929721
107Abnormality of macular pigmentation (HP:0008002)1.69705563
108Abnormality of the calcaneus (HP:0008364)1.69564907
109Poor coordination (HP:0002370)1.68692884
110Oligodactyly (HP:0012165)1.68111544
111Missing ribs (HP:0000921)1.67587693
112Optic nerve hypoplasia (HP:0000609)1.67381467
113Neoplasm of the oral cavity (HP:0100649)1.67187974
114Anencephaly (HP:0002323)1.67150373
115Abnormality of the duodenum (HP:0002246)1.67066573
116Preaxial hand polydactyly (HP:0001177)1.66599052
117Growth hormone deficiency (HP:0000824)1.66351507
118Absent radius (HP:0003974)1.65739444
119Hypoplastic pelvis (HP:0008839)1.65691359
120Abnormal hair whorl (HP:0010721)1.65595332
121Overriding aorta (HP:0002623)1.64620866
122Aplasia involving forearm bones (HP:0009822)1.64229931
123Absent forearm bone (HP:0003953)1.64229931
124Micropenis (HP:0000054)1.63644502
125Abnormality of the metopic suture (HP:0005556)1.63141709
126Aplasia/Hypoplasia of the optic nerve (HP:0008058)1.63022782
127Embryonal neoplasm (HP:0002898)1.62910338
128Overlapping toe (HP:0001845)1.62004799
129Patellar dislocation (HP:0002999)1.61384653
130Holoprosencephaly (HP:0001360)1.61238981
131Esophageal atresia (HP:0002032)1.60893617
132Papillary thyroid carcinoma (HP:0002895)1.60582821
133High anterior hairline (HP:0009890)1.60167930
134Partial agenesis of the corpus callosum (HP:0001338)1.60144382
135Elfin facies (HP:0004428)1.60047784
136Cutaneous finger syndactyly (HP:0010554)1.59977093
137Vitreoretinal degeneration (HP:0000655)1.59976927
138Cystic hygroma (HP:0000476)1.59736121
139Aplasia/Hypoplasia of the breasts (HP:0010311)1.59311910
140Supernumerary bones of the axial skeleton (HP:0009144)1.59212257
141Abnormal respiratory motile cilium morphology (HP:0005938)1.58947711
142Abnormal respiratory epithelium morphology (HP:0012253)1.58947711
143Astigmatism (HP:0000483)1.58450076
144Abnormality of the lower motor neuron (HP:0002366)1.57535812
145Facial cleft (HP:0002006)1.57001241
146Abnormality of chromosome segregation (HP:0002916)1.56689894
147Scotoma (HP:0000575)1.55391587
148Irregular epiphyses (HP:0010582)1.54347225
149Atrophy/Degeneration involving motor neurons (HP:0007373)1.54247230
150Carpal bone hypoplasia (HP:0001498)1.54082218
151Decreased testicular size (HP:0008734)1.53107648
152Breast aplasia (HP:0100783)1.52629345
153Depressed nasal ridge (HP:0000457)1.52512206
154Sloping forehead (HP:0000340)1.52507218
155Sleep apnea (HP:0010535)1.52289857
156Stenosis of the external auditory canal (HP:0000402)1.51377947
157Generalized hypotonia (HP:0001290)1.51009157
158Gonadotropin excess (HP:0000837)1.50659656
159Deviation of the thumb (HP:0009603)1.50596349

Predicted kinase interactions (KEA)

RankGene SetZ-score
1SRPK13.81785125
2MKNK13.69358808
3STK163.51006187
4CDC73.06205513
5BRD42.95688599
6MKNK22.89507983
7PNCK2.46409708
8SIK32.37758376
9TRIM282.32794018
10DYRK32.26575249
11TNIK2.09669268
12MAP3K101.99265259
13WNK31.91500352
14VRK11.89762843
15ERBB31.86926619
16CDK81.86098976
17VRK21.84231948
18UHMK11.76748792
19INSRR1.71312811
20NEK21.70593197
21WEE11.66910228
22BUB11.66733098
23EPHB21.64925320
24TAF11.63824303
25MAPK131.61179459
26MARK11.51562249
27CASK1.50612302
28CDK121.45802798
29IRAK21.37285447
30ATR1.34305409
31MAP2K71.33846185
32YES11.33797382
33PLK31.29745282
34TSSK61.28188804
35PLK41.27163914
36SIK21.25859924
37PASK1.25719069
38CDK71.23683810
39MAP3K41.22997972
40ALK1.21481325
41CDK191.17907777
42ACVR1B1.14965492
43CAMK1G1.11648641
44RPS6KA41.10883172
45EPHA41.10504220
46CCNB11.10011769
47DYRK21.09076445
48LATS11.05120719
49CHEK21.03575983
50BRSK21.02954371
51DYRK1A1.02898658
52TLK11.01925552
53PLK11.00561274
54AKT30.98218074
55CHEK10.97965898
56CDK30.92554959
57CDK180.91230147
58CDK11A0.90526224
59NEK10.90525909
60LATS20.90052571
61CDK140.89569825
62PLK20.88832147
63CDK60.85868528
64CDK150.85264639
65ATM0.84795847
66CLK10.83791075
67EIF2AK10.82195754
68DYRK1B0.82102142
69TTK0.81718332
70BCR0.81249041
71AURKB0.79131737
72CSNK1G20.78077291
73CDK10.76320550
74NTRK10.76115390
75SGK20.74323419
76NTRK20.73540077
77BRSK10.72336490
78MINK10.70992762
79BMPR1B0.70931605
80PBK0.70368926
81PRKD20.70305401
82CDK20.70157300
83MAP3K90.67418136
84GRK10.65669345
85STK30.64364659
86CAMK40.63588593
87CAMK10.62418147
88TYRO30.62143804
89CDK90.61830495
90NTRK30.61291436
91HIPK20.59473586
92CDK40.57838602
93MUSK0.57208688
94PRKD30.57147489
95TAOK20.56593445
96TGFBR10.56237698
97SGK4940.56074819
98SGK2230.56074819
99CSNK1E0.55308233
100NME10.54708452
101PRKDC0.54676984
102ERBB20.54032203
103PRKCG0.53984782
104KSR10.53342084
105STK38L0.51800778
106EIF2AK20.51090999
107CSNK2A10.50914799
108MAPK140.50095061
109CAMK1D0.49554605
110AURKA0.48987676
111WNK40.48507865
112IRAK10.48444151
113GSK3B0.48387573
114CSNK1G10.48098011
115MAPK150.44942438
116CSNK1G30.44794224
117SMG10.44683585
118RPS6KA50.43440520
119CSNK1A1L0.43111242
120AKT20.42206350
121CSNK2A20.41473736
122PRPF4B0.40558786
123FGFR20.38732347
124MAPK100.37987678
125AKT10.37604304
126MAPK90.37465073
127BRAF0.37040852
128ADRBK10.36123530
129FGFR10.35971839
130ADRBK20.35426140
131CSNK1D0.32851097
132STK240.32620792
133NUAK10.26935421

Predicted pathways (KEGG)

RankGene SetZ-score
1Phototransduction_Homo sapiens_hsa047444.65199050
2Spliceosome_Homo sapiens_hsa030403.67338333
3Mismatch repair_Homo sapiens_hsa034303.09103559
4DNA replication_Homo sapiens_hsa030302.87180563
5Homologous recombination_Homo sapiens_hsa034402.68175504
6Fanconi anemia pathway_Homo sapiens_hsa034602.52009851
7mRNA surveillance pathway_Homo sapiens_hsa030152.42923871
8Cell cycle_Homo sapiens_hsa041102.12943201
9Ribosome_Homo sapiens_hsa030102.12569163
10RNA transport_Homo sapiens_hsa030132.09766358
11Basal transcription factors_Homo sapiens_hsa030222.08457434
12Basal cell carcinoma_Homo sapiens_hsa052172.03689981
13RNA degradation_Homo sapiens_hsa030182.03357443
14Base excision repair_Homo sapiens_hsa034102.01563829
15Butirosin and neomycin biosynthesis_Homo sapiens_hsa005242.00897199
16RNA polymerase_Homo sapiens_hsa030201.93392518
17Nucleotide excision repair_Homo sapiens_hsa034201.81486651
18Terpenoid backbone biosynthesis_Homo sapiens_hsa009001.54082645
19Oocyte meiosis_Homo sapiens_hsa041141.52218788
20Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030081.52105967
21Hedgehog signaling pathway_Homo sapiens_hsa043401.49618231
22Wnt signaling pathway_Homo sapiens_hsa043101.46226980
23Nicotine addiction_Homo sapiens_hsa050331.40703701
24Ubiquitin mediated proteolysis_Homo sapiens_hsa041201.36574702
25Biosynthesis of amino acids_Homo sapiens_hsa012301.30442342
26Progesterone-mediated oocyte maturation_Homo sapiens_hsa049141.25010889
27Non-homologous end-joining_Homo sapiens_hsa034501.24695175
28Pyrimidine metabolism_Homo sapiens_hsa002401.24556601
29Maturity onset diabetes of the young_Homo sapiens_hsa049501.23464169
30Protein export_Homo sapiens_hsa030601.22852868
31Steroid biosynthesis_Homo sapiens_hsa001001.20510343
32Olfactory transduction_Homo sapiens_hsa047401.16539831
33Hippo signaling pathway_Homo sapiens_hsa043901.13934511
34Amphetamine addiction_Homo sapiens_hsa050311.09156254
35Purine metabolism_Homo sapiens_hsa002301.07924496
36Adherens junction_Homo sapiens_hsa045201.07809274
37Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa045501.06691301
38Pathogenic Escherichia coli infection_Homo sapiens_hsa051301.04996531
39Glycine, serine and threonine metabolism_Homo sapiens_hsa002601.04637858
40Synthesis and degradation of ketone bodies_Homo sapiens_hsa000721.04525653
41Melanogenesis_Homo sapiens_hsa049161.03994803
42Glycolysis / Gluconeogenesis_Homo sapiens_hsa000101.02060407
43Insulin secretion_Homo sapiens_hsa049111.01472461
44Proteasome_Homo sapiens_hsa030501.00434641
45Circadian rhythm_Homo sapiens_hsa047100.99692865
46Dopaminergic synapse_Homo sapiens_hsa047280.97092205
47Cysteine and methionine metabolism_Homo sapiens_hsa002700.96841382
48Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa009700.96240037
49Huntingtons disease_Homo sapiens_hsa050160.95922812
50Colorectal cancer_Homo sapiens_hsa052100.94757633
51Axon guidance_Homo sapiens_hsa043600.94077654
52Circadian entrainment_Homo sapiens_hsa047130.94019085
53Cocaine addiction_Homo sapiens_hsa050300.92836315
54Other types of O-glycan biosynthesis_Homo sapiens_hsa005140.89852868
55Notch signaling pathway_Homo sapiens_hsa043300.87215347
56Alcoholism_Homo sapiens_hsa050340.86880753
57Taste transduction_Homo sapiens_hsa047420.84880403
58Morphine addiction_Homo sapiens_hsa050320.84669446
59Carbon metabolism_Homo sapiens_hsa012000.83675786
60Selenocompound metabolism_Homo sapiens_hsa004500.82610125
61Retrograde endocannabinoid signaling_Homo sapiens_hsa047230.82415367
62Glutamatergic synapse_Homo sapiens_hsa047240.81151603
63GABAergic synapse_Homo sapiens_hsa047270.80827826
64Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006300.80780662
65Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005630.80366688
66Transcriptional misregulation in cancer_Homo sapiens_hsa052020.79969498
67Long-term potentiation_Homo sapiens_hsa047200.72987121
68Parkinsons disease_Homo sapiens_hsa050120.72848298
69Cardiac muscle contraction_Homo sapiens_hsa042600.72769126
70Neuroactive ligand-receptor interaction_Homo sapiens_hsa040800.72189759
71Aldosterone synthesis and secretion_Homo sapiens_hsa049250.71763733
72Pyruvate metabolism_Homo sapiens_hsa006200.71540321
73Central carbon metabolism in cancer_Homo sapiens_hsa052300.71408313
74HTLV-I infection_Homo sapiens_hsa051660.69780017
75Serotonergic synapse_Homo sapiens_hsa047260.68307918
76Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002500.68258184
77Endometrial cancer_Homo sapiens_hsa052130.68183297
78Epstein-Barr virus infection_Homo sapiens_hsa051690.67959773
79MicroRNAs in cancer_Homo sapiens_hsa052060.66250663
80Adrenergic signaling in cardiomyocytes_Homo sapiens_hsa042610.66179508
81Propanoate metabolism_Homo sapiens_hsa006400.64942738
82Lysine degradation_Homo sapiens_hsa003100.60674502
83Cholinergic synapse_Homo sapiens_hsa047250.59294203
84Pathways in cancer_Homo sapiens_hsa052000.59052009
85Glucagon signaling pathway_Homo sapiens_hsa049220.58973314
86N-Glycan biosynthesis_Homo sapiens_hsa005100.55923413
87cAMP signaling pathway_Homo sapiens_hsa040240.55789126
88Herpes simplex infection_Homo sapiens_hsa051680.54614149
89Calcium signaling pathway_Homo sapiens_hsa040200.54110755
902-Oxocarboxylic acid metabolism_Homo sapiens_hsa012100.54089817
91Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006010.52550280
92Renin secretion_Homo sapiens_hsa049240.52110066
93Thyroid hormone signaling pathway_Homo sapiens_hsa049190.51852356
94p53 signaling pathway_Homo sapiens_hsa041150.51590363
95cGMP-PKG signaling pathway_Homo sapiens_hsa040220.51564451
96Protein processing in endoplasmic reticulum_Homo sapiens_hsa041410.51175417
97Vasopressin-regulated water reabsorption_Homo sapiens_hsa049620.50884333
98ErbB signaling pathway_Homo sapiens_hsa040120.49809542
99Oxidative phosphorylation_Homo sapiens_hsa001900.49522092
100Gap junction_Homo sapiens_hsa045400.49308600
101Renal cell carcinoma_Homo sapiens_hsa052110.45890071
102Oxytocin signaling pathway_Homo sapiens_hsa049210.45602191
103TGF-beta signaling pathway_Homo sapiens_hsa043500.45517105
104Taurine and hypotaurine metabolism_Homo sapiens_hsa004300.45266679
105Long-term depression_Homo sapiens_hsa047300.45158412
106Non-small cell lung cancer_Homo sapiens_hsa052230.44983440
107Folate biosynthesis_Homo sapiens_hsa007900.41288504
108Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010400.40110272
109Prostate cancer_Homo sapiens_hsa052150.39170493
110Alzheimers disease_Homo sapiens_hsa050100.38847850
111Longevity regulating pathway - multiple species_Homo sapiens_hsa042130.38332433
112Arrhythmogenic right ventricular cardiomyopathy (ARVC)_Homo sapiens_hsa054120.37104731
113Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001300.36858378
114Thyroid cancer_Homo sapiens_hsa052160.35890782
115One carbon pool by folate_Homo sapiens_hsa006700.35831847
116Tight junction_Homo sapiens_hsa045300.33206727
117Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa005340.32372769
118SNARE interactions in vesicular transport_Homo sapiens_hsa041300.31584502
119Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005120.30633664
120Chronic myeloid leukemia_Homo sapiens_hsa052200.30115225
121Dilated cardiomyopathy_Homo sapiens_hsa054140.30055294
122Glioma_Homo sapiens_hsa052140.29505740
123FoxO signaling pathway_Homo sapiens_hsa040680.28903326
124Longevity regulating pathway - mammal_Homo sapiens_hsa042110.28200504
125Melanoma_Homo sapiens_hsa052180.27513200
126AMPK signaling pathway_Homo sapiens_hsa041520.26607090
127Bladder cancer_Homo sapiens_hsa052190.23111110
128Viral carcinogenesis_Homo sapiens_hsa052030.21520641
129HIF-1 signaling pathway_Homo sapiens_hsa040660.20474119

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