HNRNPK

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: This gene belongs to the subfamily of ubiquitously expressed heterogeneous nuclear ribonucleoproteins (hnRNPs). The hnRNPs are RNA binding proteins and they complex with heterogeneous nuclear RNA (hnRNA). These proteins are associated with pre-mRNAs in the nucleus and appear to influence pre-mRNA processing and other aspects of mRNA metabolism and transport. While all of the hnRNPs are present in the nucleus, some seem to shuttle between the nucleus and the cytoplasm. The hnRNP proteins have distinct nucleic acid binding properties. The protein encoded by this gene is located in the nucleoplasm and has three repeats of KH domains that binds to RNAs. It is distinct among other hnRNP proteins in its binding preference; it binds tenaciously to poly(C). This protein is also thought to have a role during cell cycle progession. Several alternatively spliced transcript variants have been described for this gene, however, not all of them are fully characterized. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1DNA unwinding involved in DNA replication (GO:0006268)5.31977373
2pore complex assembly (GO:0046931)4.75093699
3DNA strand elongation involved in DNA replication (GO:0006271)4.32781050
4spliceosomal tri-snRNP complex assembly (GO:0000244)4.16483423
5DNA strand elongation (GO:0022616)4.14263636
6peptidyl-arginine omega-N-methylation (GO:0035247)4.11863363
7Golgi transport vesicle coating (GO:0048200)4.11318188
8COPI coating of Golgi vesicle (GO:0048205)4.11318188
9mRNA stabilization (GO:0048255)4.04421293
10RNA stabilization (GO:0043489)4.04421293
11protein localization to kinetochore (GO:0034501)3.99847471
12DNA replication initiation (GO:0006270)3.97760403
13regulation of single stranded viral RNA replication via double stranded DNA intermediate (GO:00450913.95104013
14regulation of RNA export from nucleus (GO:0046831)3.94554885
15establishment of viral latency (GO:0019043)3.89204159
16peptidyl-arginine methylation (GO:0018216)3.87816267
17peptidyl-arginine N-methylation (GO:0035246)3.87816267
18negative regulation of mRNA splicing, via spliceosome (GO:0048025)3.87292291
19telomere maintenance via semi-conservative replication (GO:0032201)3.85052243
203-UTR-mediated mRNA stabilization (GO:0070935)3.79418149
21nucleosome disassembly (GO:0006337)3.76336939
22protein-DNA complex disassembly (GO:0032986)3.76336939
23DNA replication-dependent nucleosome assembly (GO:0006335)3.76210761
24DNA replication-dependent nucleosome organization (GO:0034723)3.76210761
25CENP-A containing nucleosome assembly (GO:0034080)3.74948873
26mitotic recombination (GO:0006312)3.73686583
27DNA topological change (GO:0006265)3.70845893
28chromatin remodeling at centromere (GO:0031055)3.68149210
29nuclear pore organization (GO:0006999)3.67024850
30kinetochore organization (GO:0051383)3.65736553
31DNA replication-independent nucleosome assembly (GO:0006336)3.64764116
32DNA replication-independent nucleosome organization (GO:0034724)3.64764116
33mitotic chromosome condensation (GO:0007076)3.57012236
34nucleobase biosynthetic process (GO:0046112)3.56848008
35heterochromatin organization (GO:0070828)3.54884943
36negative regulation of RNA splicing (GO:0033119)3.54762837
37telomere maintenance via recombination (GO:0000722)3.51803109
38mitotic metaphase plate congression (GO:0007080)3.49742079
39sister chromatid segregation (GO:0000819)3.49592527
40regulation of translational fidelity (GO:0006450)3.48261232
41viral mRNA export from host cell nucleus (GO:0046784)3.46536226
42IMP biosynthetic process (GO:0006188)3.43742013
43nuclear pore complex assembly (GO:0051292)3.42428770
44mitotic nuclear envelope disassembly (GO:0007077)3.42171719
45spindle assembly checkpoint (GO:0071173)3.39699872
46nucleotide-excision repair, DNA gap filling (GO:0006297)3.38940007
47negative regulation of mitotic sister chromatid separation (GO:2000816)3.38839593
48negative regulation of mitotic sister chromatid segregation (GO:0033048)3.38839593
49negative regulation of mitotic metaphase/anaphase transition (GO:0045841)3.38839593
50negative regulation of sister chromatid segregation (GO:0033046)3.38839593
51regulation of nucleobase-containing compound transport (GO:0032239)3.38775050
52protein complex localization (GO:0031503)3.37985580
53mitotic spindle assembly checkpoint (GO:0007094)3.37720591
54purine nucleobase biosynthetic process (GO:0009113)3.37412096
55DNA duplex unwinding (GO:0032508)3.34575581
56postreplication repair (GO:0006301)3.34364693
57DNA geometric change (GO:0032392)3.33783201
58negative regulation of chromosome segregation (GO:0051985)3.33728891
59histone arginine methylation (GO:0034969)3.32990674
60V(D)J recombination (GO:0033151)3.31125524
61establishment of integrated proviral latency (GO:0075713)3.30941072
62pre-miRNA processing (GO:0031054)3.30573702
63attachment of spindle microtubules to kinetochore (GO:0008608)3.30368635
64protein localization to chromosome, centromeric region (GO:0071459)3.30220154
65negative regulation of mRNA processing (GO:0050686)3.29980652
66DNA replication checkpoint (GO:0000076)3.28303958
67regulation of mRNA stability (GO:0043488)3.28220297
68mitotic sister chromatid segregation (GO:0000070)3.27742644
69negative regulation of metaphase/anaphase transition of cell cycle (GO:1902100)3.27604985
70spindle checkpoint (GO:0031577)3.26724843
71regulation of attachment of spindle microtubules to kinetochore (GO:0051988)3.26513511
72metaphase plate congression (GO:0051310)3.24414338
73formation of translation preinitiation complex (GO:0001731)3.23331547
74histone H2A acetylation (GO:0043968)3.22681069
75* RNA splicing, via transesterification reactions with bulged adenosine as nucleophile (GO:0000377)3.22063854
76* mRNA splicing, via spliceosome (GO:0000398)3.22063854
77dosage compensation (GO:0007549)3.21633885
78mitotic spindle checkpoint (GO:0071174)3.21456994
79* RNA splicing, via transesterification reactions (GO:0000375)3.20105674
80nuclear envelope disassembly (GO:0051081)3.19310287
81membrane disassembly (GO:0030397)3.19310287
82telomere maintenance via telomere lengthening (GO:0010833)3.18956203
83translesion synthesis (GO:0019985)3.17530401
84mitotic sister chromatid cohesion (GO:0007064)3.16959598
85histone exchange (GO:0043486)3.16875393
86paraxial mesoderm development (GO:0048339)3.16316759
87regulation of mitotic metaphase/anaphase transition (GO:0030071)3.13742204
88ATP-dependent chromatin remodeling (GO:0043044)3.12776333
89regulation of chromosome segregation (GO:0051983)3.12714161
90non-recombinational repair (GO:0000726)3.12631251
91double-strand break repair via nonhomologous end joining (GO:0006303)3.12631251
92somatic hypermutation of immunoglobulin genes (GO:0016446)3.11581122
93somatic diversification of immune receptors via somatic mutation (GO:0002566)3.11581122
94cellular protein complex localization (GO:0034629)3.11414075
95protein export from nucleus (GO:0006611)3.11161202
96chromosome condensation (GO:0030261)3.11060964
97establishment of chromosome localization (GO:0051303)3.08309390
98cellular hyperosmotic response (GO:0071474)3.05972255
99regulation of metaphase/anaphase transition of cell cycle (GO:1902099)3.05631312
100regulation of mitotic sister chromatid separation (GO:0010965)3.03921973
101regulation of mitotic sister chromatid segregation (GO:0033047)3.03921973
102regulation of sister chromatid segregation (GO:0033045)3.03921973
103regulation of RNA stability (GO:0043487)3.03432600
104spliceosomal complex assembly (GO:0000245)3.01772433
105spliceosomal snRNP assembly (GO:0000387)3.01698200
106regulation of spindle organization (GO:0090224)3.01240602
107cullin deneddylation (GO:0010388)3.00642127
108regulation of mitotic spindle organization (GO:0060236)3.00604985
109kinetochore assembly (GO:0051382)3.00030830
110histone H2B ubiquitination (GO:0033523)2.98817852
111mismatch repair (GO:0006298)2.95906015
112mRNA transport (GO:0051028)2.95793220
113nuclear envelope organization (GO:0006998)2.94006769
114protein localization to chromosome (GO:0034502)2.92711433
115IMP metabolic process (GO:0046040)2.90406150
116DNA ligation (GO:0006266)2.90348718
117termination of RNA polymerase II transcription (GO:0006369)2.88595635
118negative regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051436)2.86979083
119anaphase-promoting complex-dependent proteasomal ubiquitin-dependent protein catabolic process (GO:02.86933857
120positive regulation of intracellular steroid hormone receptor signaling pathway (GO:0033145)2.86731880
121RNA export from nucleus (GO:0006405)2.85510143
122alternative mRNA splicing, via spliceosome (GO:0000380)2.85058218
123regulation of helicase activity (GO:0051095)2.84572737
124regulation of centrosome cycle (GO:0046605)2.84357020
125regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051439)2.83026163
126embryonic process involved in female pregnancy (GO:0060136)2.82860465
127pentose-phosphate shunt (GO:0006098)2.82552105
128DNA conformation change (GO:0071103)2.81500381
129DNA double-strand break processing (GO:0000729)2.81249186
130mRNA export from nucleus (GO:0006406)2.80460942
131positive regulation of RNA splicing (GO:0033120)2.79678087
132intra-S DNA damage checkpoint (GO:0031573)2.79232088
133chromatin assembly or disassembly (GO:0006333)2.77252171
134negative regulation of mRNA metabolic process (GO:1903312)2.76533253
135regulation of sister chromatid cohesion (GO:0007063)2.76214591
136regulation of NFAT protein import into nucleus (GO:0051532)2.76119084
137negative regulation of mitosis (GO:0045839)2.75289354
138positive regulation of cell cycle checkpoint (GO:1901978)2.75037507
139chromosome segregation (GO:0007059)2.74617245
140positive regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051437)2.73665285
141glucocorticoid receptor signaling pathway (GO:0042921)2.73482825
142negative regulation of histone methylation (GO:0031061)2.72390849
143regulation of DNA damage checkpoint (GO:2000001)2.71578204
144regulation of transcription involved in G1/S transition of mitotic cell cycle (GO:0000083)2.68460216
145planar cell polarity pathway involved in neural tube closure (GO:0090179)2.67975731
146NADPH regeneration (GO:0006740)2.67651042
147regulation of establishment of planar polarity involved in neural tube closure (GO:0090178)2.66579038
148regulation of protein insertion into mitochondrial membrane involved in apoptotic signaling pathway 2.66310255
149positive regulation of protein insertion into mitochondrial membrane involved in apoptotic signaling2.66310255
150positive regulation of chromosome segregation (GO:0051984)2.66207060
151epithelial cell differentiation involved in prostate gland development (GO:0060742)2.64317578
152negative regulation of DNA repair (GO:0045738)2.63080813
153DNA packaging (GO:0006323)2.61529043

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1E2F7_22180533_ChIP-Seq_HELA_Human9.77087550
2FOXM1_23109430_ChIP-Seq_U2OS_Human4.66214886
3E2F4_17652178_ChIP-ChIP_JURKAT_Human4.29185727
4MYC_18555785_ChIP-Seq_MESCs_Mouse4.01677846
5FOXM1_25889361_ChIP-Seq_OE33_AND_U2OS_Human3.40333268
6EKLF_21900194_ChIP-Seq_ERYTHROCYTE_Mouse3.23942958
7KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human3.17538448
8EST1_17652178_ChIP-ChIP_JURKAT_Human2.95788844
9NUCKS1_24931609_ChIP-Seq_HEPATOCYTES_Mouse2.90567472
10HCFC1_20581084_ChIP-Seq_MESCs_Mouse2.80292307
11MYC_19030024_ChIP-ChIP_MESCs_Mouse2.73333225
12MYC_19079543_ChIP-ChIP_MESCs_Mouse2.68970299
13GABP_17652178_ChIP-ChIP_JURKAT_Human2.65344744
14NELFA_20434984_ChIP-Seq_ESCs_Mouse2.60752518
15RBPJ_22232070_ChIP-Seq_NCS_Mouse2.59079529
16* KDM5B_21448134_ChIP-Seq_MESCs_Mouse2.58502596
17CREB1_15753290_ChIP-ChIP_HEK293T_Human2.50285149
18MYBL1_21750041_ChIP-ChIP_SPERMATOCYTES_Mouse2.49828073
19MYC_18358816_ChIP-ChIP_MESCs_Mouse2.46164871
20HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse2.46067557
21ETS1_20019798_ChIP-Seq_JURKAT_Human2.40467700
22* XRN2_22483619_ChIP-Seq_HELA_Human2.35786126
23AR_21909140_ChIP-Seq_LNCAP_Human2.34947725
24JARID1A_20064375_ChIP-Seq_MESCs_Mouse2.32264661
25CHD1_19587682_ChIP-ChIP_MESCs_Mouse2.31739878
26ELF1_17652178_ChIP-ChIP_JURKAT_Human2.30663784
27EGR1_19374776_ChIP-ChIP_THP-1_Human2.24146457
28E2F1_21310950_ChIP-Seq_MCF-7_Human2.19217702
29MYBL2_22936984_ChIP-ChIP_MESCs_Mouse2.15625769
30VDR_23849224_ChIP-Seq_CD4+_Human2.14176183
31PPARG_23326641_ChIP-Seq_C3H10T1-2_Mouse2.13133550
32* YY1_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse2.11018649
33NOTCH1_17114293_ChIP-ChIP_T-ALL_Human2.08368715
34TP63_19390658_ChIP-ChIP_HaCaT_Human2.03047602
35ELK1_19687146_ChIP-ChIP_HELA_Human1.99047492
36FOXP3_21729870_ChIP-Seq_TREG_Human1.97983495
37CLOCK_20551151_ChIP-Seq_293T_Human1.97380197
38SALL1_21062744_ChIP-ChIP_HESCs_Human1.93790675
39MYCN_18555785_ChIP-Seq_MESCs_Mouse1.92374474
40TTF2_22483619_ChIP-Seq_HELA_Human1.90471813
41THAP11_20581084_ChIP-Seq_MESCs_Mouse1.89650925
42E2F1_18555785_ChIP-Seq_MESCs_Mouse1.88455397
43* CIITA_25753668_ChIP-Seq_RAJI_Human1.85625265
44DCP1A_22483619_ChIP-Seq_HELA_Human1.83669137
45TP63_17297297_ChIP-ChIP_HaCaT_Human1.78801647
46ZFX_18555785_ChIP-Seq_MESCs_Mouse1.76622159
47FOXO3_22982991_ChIP-Seq_MACROPHAGES_Mouse1.75622795
48GABP_19822575_ChIP-Seq_HepG2_Human1.74768459
49CCND1_20090754_ChIP-ChIP_RETINA_Mouse1.71864567
50HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human1.70478510
51POU5F1_18555785_ChIP-Seq_MESCs_Mouse1.68902142
52HOXB4_20404135_ChIP-ChIP_EML_Mouse1.65374736
53ZFP42_18358816_ChIP-ChIP_MESCs_Mouse1.63467314
54ZNF263_19887448_ChIP-Seq_K562_Human1.63302003
55SOX2_18555785_ChIP-Seq_MESCs_Mouse1.52938513
56* PADI4_21655091_ChIP-ChIP_MCF-7_Human1.50660327
57TAL1_20887958_ChIP-Seq_HPC-7_Mouse1.46729972
58MYC_22102868_ChIP-Seq_BL_Human1.46719151
59SPI1_22790984_ChIP-Seq_ERYTHROLEUKEMIA_Mouse1.40698015
60SOX9_22984422_ChIP-ChIP_TESTIS_Rat1.39926331
61KDM5A_27292631_Chip-Seq_BREAST_Human1.39690700
62NANOG_18700969_ChIP-ChIP_MESCs_Mouse1.35549544
63MYCN_21190229_ChIP-Seq_SHEP-21N_Human1.35469813
64NANOG_18555785_ChIP-Seq_MESCs_Mouse1.34107126
65VDR_21846776_ChIP-Seq_THP-1_Human1.33425897
66ASXL1_24218140_ChIP-Seq_BMDM_Mouse1.33372278
67KLF4_19030024_ChIP-ChIP_MESCs_Mouse1.27417832
68ZFP281_18757296_ChIP-ChIP_E14_Mouse1.26235292
69PDX1_19855005_ChIP-ChIP_MIN6_Mouse1.26210016
70CHD1_26751641_Chip-Seq_LNCaP_Human1.25720241
71DMRT1_21621532_ChIP-ChIP_FETAL_Ovary1.25501828
72TCF3_18467660_ChIP-ChIP_MESCs_Mouse1.25165196
73TCFAP2C_20176728_ChIP-ChIP_TROPHOBLAST_STEM_CELLS_Mouse1.24125009
74* CREB1_23762244_ChIP-Seq_HIPPOCAMPUS_Rat1.22451688
75YY1_21170310_ChIP-Seq_MESCs_Mouse1.21275636
76TBP_23326641_ChIP-Seq_C3H10T1-2_Mouse1.21165274
77ERG_20887958_ChIP-Seq_HPC-7_Mouse1.21150005
78SMARCA4_20176728_ChIP-ChIP_TSCs_Mouse1.20424636
79KDM2B_26808549_Chip-Seq_SIL-ALL_Human1.19531981
80POU5F1_18358816_ChIP-ChIP_MESCs_Mouse1.19424879
81CIITA_18437201_ChIP-ChIP_Raji_B_and_iDC_Human1.18642977
82E2F4_21247883_ChIP-Seq_LYMPHOBLASTOID_Human1.17712373
83PRDM5_23873026_ChIP-Seq_MEFs_Mouse1.16204486
84SFPI1_20887958_ChIP-Seq_HPC-7_Mouse1.14733293
85POU5F1_16153702_ChIP-ChIP_HESCs_Human1.14466859
86* TCF7_22412390_ChIP-Seq_EML_Mouse1.14405593
87WT1_20215353_ChIP-ChIP_NEPHRON_PROGENITOR_Mouse1.14373938
88* CREM_20920259_ChIP-Seq_GC1-SPG_Mouse1.14143318
89TFEB_21752829_ChIP-Seq_HELA_Human1.13634204
90SOX2_19030024_ChIP-ChIP_MESCs_Mouse1.13580634
91SALL4_18804426_ChIP-ChIP_MESCs_Mouse1.13252499
92KLF6_26769127_Chip-Seq_PDAC-Cell_line_Human1.12490569
93CNOT3_19339689_ChIP-ChIP_MESCs_Mouse1.10788252
94SOX2_16153702_ChIP-ChIP_HESCs_Human1.08570440
95TRIM28_19339689_ChIP-ChIP_MESCs_Mouse1.08492570
96HOXD13_18407260_ChIP-ChIP_DEVELOPING-LIMBS_Mouse1.08463413
97KLF4_18358816_ChIP-ChIP_MESCs_Mouse1.06895643
98SRF_21415370_ChIP-Seq_HL-1_Mouse1.05773661
99HSF1_23293686_ChIP-Seq_STHDH_STRIATAL_Mouse1.05501528
100WT1_19549856_ChIP-ChIP_CCG9911_Human1.02395858
101NANOG_16153702_ChIP-ChIP_HESCs_Human1.02373376
102E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse1.01480307
103ELK3_25401928_ChIP-Seq_HUVEC_Human0.99996724
104MYC_18940864_ChIP-ChIP_HL60_Human0.99733649
105NANOG_21062744_ChIP-ChIP_HESCs_Human0.99068706
106ZFP281_18358816_ChIP-ChIP_MESCs_Mouse0.98943007
107NR1H3_23393188_ChIP-Seq_ATHEROSCLEROTIC-FOAM_Human0.98380263
108KDM2B_26808549_Chip-Seq_HPB-ALL_Human0.97504430
109MAF_26560356_Chip-Seq_TH1_Human0.94778003
110ZIC3_20872845_ChIP-ChIP_MESCs_Mouse0.94586260
111GFI1B_20887958_ChIP-Seq_HPC-7_Mouse0.94440381
112* DMRT1_23473982_ChIP-Seq_TESTES_Mouse0.93274951
113KLF4_18555785_ChIP-Seq_MESCs_Mouse0.92120603
114P300_27058665_Chip-Seq_ZR-75-30cells_Human0.91916275
115ASH2L_23239880_ChIP-Seq_MESCs_Mouse0.91345034
116PKCTHETA_26484144_Chip-Seq_BREAST_Human0.91309353
117TAL1_20566737_ChIP-Seq_PRIMARY_FETAL_LIVER_ERYTHROID_Mouse0.90181237
118STAT3_1855785_ChIP-Seq_MESCs_Mouse0.89729846
119FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse0.88171060
120CUX1_19635798_ChIP-ChIP_MULTIPLE_HUMAN_CANCER_TYPES_Human0.87782057
121CREB1_20920259_ChIP-Seq_GC1-SPG_Mouse0.87446767
122FLI1_20887958_ChIP-Seq_HPC-7_Mouse0.87148179
123ESR1_15608294_ChIP-ChIP_MCF-7_Human0.87106315
124POU5F1_18700969_ChIP-ChIP_MESCs_Mouse0.86920418
125SOX17_20123909_ChIP-Seq_XEN_Mouse0.86188338
126SPI1_22096565_ChIP-ChIP_GC-B_Mouse0.85527831
127SMAD1_18555785_ChIP-Seq_MESCs_Mouse0.81716943
128EWS_26573619_Chip-Seq_HEK293_Human0.80173656
129TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat0.79171978
130ELK1_22589737_ChIP-Seq_MCF10A_Human0.76115830
131* DACH1_20351289_ChIP-Seq_MDA-MB-231_Human0.76077804

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0010094_abnormal_chromosome_stability4.00941319
2MP0003693_abnormal_embryo_hatching3.73001432
3MP0004957_abnormal_blastocyst_morpholog3.54891552
4MP0003111_abnormal_nucleus_morphology3.45914809
5MP0008057_abnormal_DNA_replication3.43205589
6MP0002009_preneoplasia3.42011454
7MP0003077_abnormal_cell_cycle3.35065457
8MP0003123_paternal_imprinting2.98834638
9MP0008007_abnormal_cellular_replicative2.94288261
10MP0008058_abnormal_DNA_repair2.93831359
11MP0002877_abnormal_melanocyte_morpholog2.64691990
12MP0003121_genomic_imprinting2.52113288
13MP0008932_abnormal_embryonic_tissue2.48032776
14MP0003705_abnormal_hypodermis_morpholog2.41222076
15MP0010030_abnormal_orbit_morphology2.33513938
16MP0000537_abnormal_urethra_morphology2.31313790
17MP0003221_abnormal_cardiomyocyte_apopto2.18563058
18MP0008877_abnormal_DNA_methylation2.11920799
19MP0001730_embryonic_growth_arrest2.03926910
20MP0010234_abnormal_vibrissa_follicle1.98481306
21MP0000350_abnormal_cell_proliferation1.96829094
22MP0006054_spinal_hemorrhage1.94078283
23MP0009053_abnormal_anal_canal1.89577815
24MP0003122_maternal_imprinting1.71253503
25MP0002396_abnormal_hematopoietic_system1.70913129
26MP0001293_anophthalmia1.68727174
27MP0003890_abnormal_embryonic-extraembry1.65271762
28MP0001697_abnormal_embryo_size1.62735705
29MP0002938_white_spotting1.62401269
30MP0002085_abnormal_embryonic_tissue1.61026710
31MP0002084_abnormal_developmental_patter1.60844418
32MP0003566_abnormal_cell_adhesion1.60329660
33MP0003786_premature_aging1.55620675
34MP0004185_abnormal_adipocyte_glucose1.55014044
35MP0003315_abnormal_perineum_morphology1.54502131
36MP0004197_abnormal_fetal_growth/weight/1.51361150
37MP0001672_abnormal_embryogenesis/_devel1.51161724
38MP0005380_embryogenesis_phenotype1.51161724
39MP0010352_gastrointestinal_tract_polyps1.50565867
40MP0000566_synostosis1.45282637
41MP0003937_abnormal_limbs/digits/tail_de1.43765772
42MP0004808_abnormal_hematopoietic_stem1.39122323
43MP0002080_prenatal_lethality1.39074093
44MP0003984_embryonic_growth_retardation1.37129483
45MP0000049_abnormal_middle_ear1.35615811
46MP0002088_abnormal_embryonic_growth/wei1.34624867
47MP0003119_abnormal_digestive_system1.31432790
48MP0003942_abnormal_urinary_system1.29167995
49MP0002653_abnormal_ependyma_morphology1.27716107
50MP0005501_abnormal_skin_physiology1.24903064
51MP0001346_abnormal_lacrimal_gland1.23807011
52MP0002796_impaired_skin_barrier1.21466061
53MP0003567_abnormal_fetal_cardiomyocyte1.20356380
54MP0004264_abnormal_extraembryonic_tissu1.19423501
55MP0003787_abnormal_imprinting1.19406381
56MP0008789_abnormal_olfactory_epithelium1.19123001
57MP0005623_abnormal_meninges_morphology1.18262125
58MP0002282_abnormal_trachea_morphology1.17002172
59MP0008260_abnormal_autophagy1.16845545
60MP0002751_abnormal_autonomic_nervous1.16807340
61MP0002102_abnormal_ear_morphology1.15320180
62MP0003115_abnormal_respiratory_system1.15169688
63MP0002086_abnormal_extraembryonic_tissu1.14237282
64MP0005248_abnormal_Harderian_gland1.13874193
65MP0005621_abnormal_cell_physiology1.13630270
66MP0000490_abnormal_crypts_of1.12532824
67MP0000428_abnormal_craniofacial_morphol1.12432683
68MP0000313_abnormal_cell_death1.10816875
69MP0010307_abnormal_tumor_latency1.08979567
70MP0002111_abnormal_tail_morphology1.07662865
71MP0006292_abnormal_olfactory_placode1.06846373
72MP0005076_abnormal_cell_differentiation1.06804512
73MP0003091_abnormal_cell_migration1.06721117
74MP0001286_abnormal_eye_development1.06259743
75MP0002210_abnormal_sex_determination1.04812161
76MP0003300_gastrointestinal_ulcer1.04326262
77MP0002166_altered_tumor_susceptibility1.03066599
78MP0009697_abnormal_copulation1.02321656
79MP0003385_abnormal_body_wall1.01660516
80MP0002092_abnormal_eye_morphology1.01580405
81MP0003861_abnormal_nervous_system1.00988003
82MP0004782_abnormal_surfactant_physiolog1.00136146
83MP0003755_abnormal_palate_morphology1.00020445
84MP0000534_abnormal_ureter_morphology0.98965120
85MP0001727_abnormal_embryo_implantation0.98451898
86MP0004133_heterotaxia0.97329286
87MP0005384_cellular_phenotype0.96119888
88MP0002932_abnormal_joint_morphology0.96078499
89MP0001849_ear_inflammation0.95274078
90MP0003935_abnormal_craniofacial_develop0.95242261
91MP0009278_abnormal_bone_marrow0.92921899
92MP0001145_abnormal_male_reproductive0.90115863
93MP0000579_abnormal_nail_morphology0.89461954
94MP0003763_abnormal_thymus_physiology0.89316753
95MP0001340_abnormal_eyelid_morphology0.89160392
96MP0000703_abnormal_thymus_morphology0.87892370
97MP0002019_abnormal_tumor_incidence0.87575895
98MP0003943_abnormal_hepatobiliary_system0.87506760
99MP0006072_abnormal_retinal_apoptosis0.87487399
100MP0002697_abnormal_eye_size0.86726038
101MP0002116_abnormal_craniofacial_bone0.86714175
102MP0003283_abnormal_digestive_organ0.86133752
103MP0009250_abnormal_appendicular_skeleto0.85697482
104MP0005451_abnormal_body_composition0.85154235
105MP0002006_tumorigenesis0.83155603
106MP0002098_abnormal_vibrissa_morphology0.82926039
107MP0002233_abnormal_nose_morphology0.81212541
108MP0000631_abnormal_neuroendocrine_gland0.80351472
109MP0002114_abnormal_axial_skeleton0.79808898
110MP0000377_abnormal_hair_follicle0.79719063
111MP0003938_abnormal_ear_development0.79145263
112MP0000733_abnormal_muscle_development0.78891944
113MP0005391_vision/eye_phenotype0.78779282
114MP0004858_abnormal_nervous_system0.78716173
115MP0003941_abnormal_skin_development0.77956907
116MP0003453_abnormal_keratinocyte_physiol0.77568894
117MP0001529_abnormal_vocalization0.76690091
118MP0004233_abnormal_muscle_weight0.76621304
119MP0002160_abnormal_reproductive_system0.76368566
120MP0000432_abnormal_head_morphology0.76338302
121MP0000569_abnormal_digit_pigmentation0.75857769
122MP0000858_altered_metastatic_potential0.75704629
123MP0009703_decreased_birth_body0.75612765
124MP0010630_abnormal_cardiac_muscle0.75219028
125MP0009672_abnormal_birth_weight0.74887962
126MP0001216_abnormal_epidermal_layer0.74464630
127MP0005499_abnormal_olfactory_system0.74318110
128MP0005394_taste/olfaction_phenotype0.74318110
129MP0002234_abnormal_pharynx_morphology0.73151315
130MP0000653_abnormal_sex_gland0.72929669
131MP0001915_intracranial_hemorrhage0.72462207
132MP0002095_abnormal_skin_pigmentation0.71606452
133MP0004134_abnormal_chest_morphology0.71081779
134MP0002081_perinatal_lethality0.70396352
135MP0002177_abnormal_outer_ear0.68932104
136MP0001929_abnormal_gametogenesis0.67892245
137MP0000477_abnormal_intestine_morphology0.67849348
138MP0001188_hyperpigmentation0.67688419

Predicted human phenotypes

RankGene SetZ-score
1Cortical dysplasia (HP:0002539)4.09193607
2Colon cancer (HP:0003003)3.49893658
3Hyperacusis (HP:0010780)3.41698115
4Medulloblastoma (HP:0002885)3.24419708
5Aplasia/Hypoplasia of the 4th metacarpal (HP:0010042)3.21935500
6Short 4th metacarpal (HP:0010044)3.21935500
7Birth length less than 3rd percentile (HP:0003561)3.19672427
8Abnormality of the anterior horn cell (HP:0006802)3.13337538
9Degeneration of anterior horn cells (HP:0002398)3.13337538
10Insidious onset (HP:0003587)3.09134803
11Termporal pattern (HP:0011008)3.09134803
12Ependymoma (HP:0002888)2.98927728
13Selective tooth agenesis (HP:0001592)2.95054220
14Insomnia (HP:0100785)2.94715721
15Patellar aplasia (HP:0006443)2.92732984
16Volvulus (HP:0002580)2.87284319
17Aplasia/Hypoplasia of the patella (HP:0006498)2.79387779
18Abnormal lung lobation (HP:0002101)2.79046094
19Increased nuchal translucency (HP:0010880)2.77612797
20Spastic diplegia (HP:0001264)2.77152559
21Abnormal number of incisors (HP:0011064)2.70977529
2211 pairs of ribs (HP:0000878)2.66789736
23Abnormality of the labia minora (HP:0012880)2.64170237
24Proximal placement of thumb (HP:0009623)2.60961013
25Shoulder girdle muscle weakness (HP:0003547)2.53355010
26Deviation of the thumb (HP:0009603)2.51906106
27Nephroblastoma (Wilms tumor) (HP:0002667)2.38034265
28Asymmetry of the thorax (HP:0001555)2.37458918
29Overlapping toe (HP:0001845)2.34881288
30Spinal cord lesions (HP:0100561)2.30635314
31Syringomyelia (HP:0003396)2.30635314
32Embryonal renal neoplasm (HP:0011794)2.30407001
33Small intestinal stenosis (HP:0012848)2.30092627
34Duodenal stenosis (HP:0100867)2.30092627
35Agnosia (HP:0010524)2.29150258
36Chromsome breakage (HP:0040012)2.28774051
37Overriding aorta (HP:0002623)2.28432782
38Abnormality of chromosome stability (HP:0003220)2.27461923
39Meckel diverticulum (HP:0002245)2.26406443
40Neoplasm of the pancreas (HP:0002894)2.24196206
41Uterine leiomyosarcoma (HP:0002891)2.23728354
42Leiomyosarcoma (HP:0100243)2.23728354
43Abnormality of the 4th metacarpal (HP:0010012)2.23586432
44Atrophy/Degeneration involving motor neurons (HP:0007373)2.22271512
45Pelvic girdle muscle weakness (HP:0003749)2.22271448
46Abnormality of the ileum (HP:0001549)2.21676663
47Optic nerve coloboma (HP:0000588)2.20026499
48Vertebral arch anomaly (HP:0008438)2.14986549
49Atresia of the external auditory canal (HP:0000413)2.14787330
50Aplasia/Hypoplasia of the sternum (HP:0006714)2.13670179
51Reticulocytopenia (HP:0001896)2.10270039
52Renal duplication (HP:0000075)2.09402001
53Ankyloglossia (HP:0010296)2.08295415
54Large earlobe (HP:0009748)2.07525153
55Abnormality of the distal phalanx of the thumb (HP:0009617)2.07206681
56Chromosomal breakage induced by crosslinking agents (HP:0003221)2.07178158
57Abnormality of the duodenum (HP:0002246)2.06562012
58Subacute progressive viral hepatitis (HP:0006572)2.06523382
59Astrocytoma (HP:0009592)2.06485292
60Abnormality of the astrocytes (HP:0100707)2.06485292
61Pseudobulbar signs (HP:0002200)2.06467144
62Aplasia/Hypoplasia of the uvula (HP:0010293)2.06436689
63Oral leukoplakia (HP:0002745)2.05296722
64Broad face (HP:0000283)2.04809232
65Aplastic anemia (HP:0001915)2.03834430
66Long palpebral fissure (HP:0000637)2.03718732
67Ovarian neoplasm (HP:0100615)2.02420169
68Breast hypoplasia (HP:0003187)2.02073499
69Intestinal atresia (HP:0011100)2.02041782
70Abnormality of oral frenula (HP:0000190)2.01746759
71Missing ribs (HP:0000921)2.01421351
72Abnormality of the preputium (HP:0100587)2.00851613
73Arnold-Chiari malformation (HP:0002308)2.00655570
74Neoplasm of the colon (HP:0100273)1.98902230
75Absent radius (HP:0003974)1.98367558
76Ectopic kidney (HP:0000086)1.98363113
77Elfin facies (HP:0004428)1.97217267
78Pointed chin (HP:0000307)1.94566884
79Transitional cell carcinoma of the bladder (HP:0006740)1.94190967
80Myelodysplasia (HP:0002863)1.92113087
81Progressive external ophthalmoplegia (HP:0000590)1.92056354
82Hereditary nonpolyposis colorectal carcinoma (HP:0006716)1.91845935
83Heterotopia (HP:0002282)1.91653809
84Hepatoblastoma (HP:0002884)1.90969017
85Glioma (HP:0009733)1.89807383
86Abnormality of the hip-girdle musculature (HP:0001445)1.88951804
87Abnormality of the musculature of the pelvis (HP:0001469)1.88951804
88Metaphyseal cupping (HP:0003021)1.88671909
89Absent forearm bone (HP:0003953)1.88005239
90Aplasia involving forearm bones (HP:0009822)1.88005239
91Distal lower limb amyotrophy (HP:0008944)1.86678049
92Premature graying of hair (HP:0002216)1.86671820
93Orthostatic hypotension (HP:0001278)1.86496655
94Spina bifida occulta (HP:0003298)1.85473575
95Sloping forehead (HP:0000340)1.84807632
96High anterior hairline (HP:0009890)1.84658415
97Abnormality of the calcaneus (HP:0008364)1.82038965
98Broad distal phalanx of finger (HP:0009836)1.80870293
99Flat acetabular roof (HP:0003180)1.79506319
100Supernumerary spleens (HP:0009799)1.76634829
101Obsessive-compulsive behavior (HP:0000722)1.76517418
102Microvesicular hepatic steatosis (HP:0001414)1.76434143
103Limb-girdle muscle atrophy (HP:0003797)1.76398536
104Short middle phalanx of the 5th finger (HP:0004220)1.76339153
105Bladder carcinoma (HP:0002862)1.76274192
106Bladder neoplasm (HP:0009725)1.76274192
107Basal cell carcinoma (HP:0002671)1.75864764
108Back pain (HP:0003418)1.75645881
109Neoplasm of the oral cavity (HP:0100649)1.74565427
110Glossoptosis (HP:0000162)1.74355366
111Patellar dislocation (HP:0002999)1.73355257
112Reticulocytosis (HP:0001923)1.72628974
113Neoplasm of the rectum (HP:0100743)1.71342404
114Freckling (HP:0001480)1.70137635
115Hypoplasia of the capital femoral epiphysis (HP:0003090)1.70052914
116Viral hepatitis (HP:0006562)1.69778458
117Rhabdomyosarcoma (HP:0002859)1.69154441
118Skull defect (HP:0001362)1.68594386
119Abnormality of the metopic suture (HP:0005556)1.67704008
120Centrally nucleated skeletal muscle fibers (HP:0003687)1.66959562
121Multiple enchondromatosis (HP:0005701)1.66115625
122Facial hemangioma (HP:0000329)1.65981499
123Decreased number of large peripheral myelinated nerve fibers (HP:0003387)1.65800370
124Rimmed vacuoles (HP:0003805)1.65474851
125Biliary tract neoplasm (HP:0100574)1.65204177
126Facial cleft (HP:0002006)1.64785386
127Horseshoe kidney (HP:0000085)1.64440883
128Papillary thyroid carcinoma (HP:0002895)1.64089362
129Trigonocephaly (HP:0000243)1.63951353
130Broad alveolar ridges (HP:0000187)1.63408405
131Amaurosis fugax (HP:0100576)1.62961892
132Embryonal neoplasm (HP:0002898)1.62739218
133Rough bone trabeculation (HP:0100670)1.62446236
134Carpal bone hypoplasia (HP:0001498)1.62263640
135Cutis marmorata (HP:0000965)1.61930176
136Renovascular hypertension (HP:0100817)1.61390621
137Gastrointestinal atresia (HP:0002589)1.61247370
138Lower limb amyotrophy (HP:0007210)1.60804972
139Relative macrocephaly (HP:0004482)1.60532481
140Abnormality of the carotid arteries (HP:0005344)1.59747791
141Triphalangeal thumb (HP:0001199)1.59286289
142Flared metaphyses (HP:0003015)1.58875530
143Tracheoesophageal fistula (HP:0002575)1.58495578
144Bone marrow hypocellularity (HP:0005528)1.58481925
145Preaxial hand polydactyly (HP:0001177)1.58206646
146Cerebral hypomyelination (HP:0006808)1.57339007
147Gastrointestinal carcinoma (HP:0002672)1.56793029
148Malignant gastrointestinal tract tumors (HP:0006749)1.56793029
149Abnormality of the intervertebral disk (HP:0005108)1.56663761
150Deep philtrum (HP:0002002)1.56317746
151Neoplasm of the small intestine (HP:0100833)1.56259073
152Intestinal polyp (HP:0005266)1.56189932
153Abnormal foot bone ossification (HP:0010675)1.55905707
154Generalized hypotonia (HP:0001290)1.55780265
155Esophageal atresia (HP:0002032)1.55568093
156Abnormality of chromosome segregation (HP:0002916)1.55067190
157Broad palm (HP:0001169)1.54697171
158Hammertoe (HP:0001765)1.54010285
159Neuroblastoma (HP:0003006)1.53132938
160Primitive neuroectodermal tumor (HP:0030065)1.53132938
161Neuroblastic tumors (HP:0004376)1.53132938
162Peripheral primitive neuroectodermal neoplasm (HP:0030067)1.53132938
163Renal cell carcinoma (HP:0005584)1.53001650
164Omphalocele (HP:0001539)1.52807629
165Abnormality of the salivary glands (HP:0010286)1.52177541
166Coarctation of aorta (HP:0001680)1.49905201
167Disproportionate tall stature (HP:0001519)1.49131938
168Ulnar bowing (HP:0003031)1.47832740
169Radioulnar synostosis (HP:0002974)1.47477448
170Abnormality of reticulocytes (HP:0004312)1.47439426

Predicted kinase interactions (KEA)

RankGene SetZ-score
1BUB14.73398483
2CDC74.43611333
3WEE13.65064427
4TSSK63.21398819
5SMG12.94092440
6MKNK12.93826321
7PASK2.93163144
8SRPK12.88970745
9EIF2AK12.71247631
10ACVR1B2.60938393
11TRIB32.27259330
12TGFBR12.18421072
13BRSK22.16411772
14CCNB12.08036043
15PRPF4B2.04690589
16PLK32.02402158
17NEK21.98239448
18ICK1.94222344
19STK161.91791637
20TESK21.89964710
21DYRK31.85008778
22NEK11.83132585
23ATR1.80658129
24ERBB31.77906100
25MKNK21.69720409
26EIF2AK31.68987154
27PLK11.68200248
28SIK31.62234450
29LATS21.59173231
30TTK1.58626046
31BRSK11.56051414
32PLK41.55763604
33VRK11.55430594
34BCR1.54674199
35AURKB1.48224115
36FGFR41.46413379
37RPS6KB21.35561854
38PAK41.34319141
39CDK71.30840689
40CDK81.24231762
41KSR21.21903636
42BRD41.18411613
43CHEK11.17117171
44LATS11.16929412
45CHEK21.15678100
46RPS6KA41.13447415
47SCYL21.11350787
48LIMK11.10269100
49TESK11.09796311
50PKN21.05526770
51TLK11.05321164
52MAP3K101.04744024
53EEF2K1.02287700
54AURKA0.94466616
55FGFR10.93788432
56KSR10.92813706
57ATM0.88375408
58CDK40.86479089
59STK100.86012809
60VRK20.83935774
61DYRK20.83726438
62MAP3K80.81499016
63MAP3K140.80550005
64YES10.80316071
65NEK90.79296270
66* CDK20.78511879
67PTK60.78123901
68TTN0.76693849
69TAF10.76448486
70* CDK10.74154357
71SIK10.73765838
72CLK10.73152863
73MAP3K60.73043980
74MTOR0.69150180
75RAF10.64440644
76RET0.63234944
77CSNK1G30.61786215
78MELK0.61540209
79EIF2AK20.61440961
80PBK0.60698273
81UHMK10.60653485
82PLK20.59263005
83MAP2K70.54920114
84CSNK2A10.54847187
85CSNK2A20.53846258
86EPHB10.53345804
87TYRO30.52795270
88STK40.52588136
89CDK60.52221245
90CDK90.49503381
91ERBB40.48802732
92BMX0.48140821
93FGFR20.45518122
94CDK120.44517904
95NTRK10.44207598
96PNCK0.43869678
97RIPK10.43817525
98LRRK20.41922800
99CSNK1A1L0.41676832
100CDK180.40975207
101DYRK1B0.40018693
102PRKDC0.39587151
103PDGFRA0.38778967
104AKT20.38698861
105PAK10.37654084
106EPHB20.36676865
107ILK0.36661875
108CDK140.36300490
109RPS6KA50.36077262
110CDK30.36028384
111WNK30.35418254
112EPHA20.35229506
113BMPR1B0.34394202
114PRKCI0.34310800
115NEK60.32167856
116CDK150.31019600
117CSF1R0.31006290
118MAPK90.30835790
119MAPK140.30024435
120CDK11A0.29937925
121ZAK0.29512334
122RPS6KB10.29337055
123BTK0.29201143
124CSNK1G10.28989041
125KDR0.28241474
126CHUK0.27111711
127ITK0.25759438
128CDK190.24517871
129MAPK130.24473410
130PAK20.24329321
131ALK0.24125076
132ERBB20.24061656

Predicted pathways (KEGG)

RankGene SetZ-score
1DNA replication_Homo sapiens_hsa030304.60196966
2Mismatch repair_Homo sapiens_hsa034304.14506434
3* Spliceosome_Homo sapiens_hsa030403.74603111
4Cell cycle_Homo sapiens_hsa041103.17399501
5RNA transport_Homo sapiens_hsa030133.07130275
6Base excision repair_Homo sapiens_hsa034102.99442255
7Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030082.97228533
8Proteasome_Homo sapiens_hsa030502.93644788
9Nucleotide excision repair_Homo sapiens_hsa034202.88273160
10Homologous recombination_Homo sapiens_hsa034402.67948793
11Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa009702.53319897
12RNA polymerase_Homo sapiens_hsa030202.47409367
13Non-homologous end-joining_Homo sapiens_hsa034502.34656988
14mRNA surveillance pathway_Homo sapiens_hsa030152.21642931
15Fanconi anemia pathway_Homo sapiens_hsa034602.06350863
16Butirosin and neomycin biosynthesis_Homo sapiens_hsa005242.00931011
17RNA degradation_Homo sapiens_hsa030181.97617778
18Basal transcription factors_Homo sapiens_hsa030221.93841273
19One carbon pool by folate_Homo sapiens_hsa006701.92117408
20Pyrimidine metabolism_Homo sapiens_hsa002401.87120222
21Ribosome_Homo sapiens_hsa030101.83408083
22p53 signaling pathway_Homo sapiens_hsa041151.54618138
23Pathogenic Escherichia coli infection_Homo sapiens_hsa051301.43352904
24Ubiquitin mediated proteolysis_Homo sapiens_hsa041201.36503092
25Epstein-Barr virus infection_Homo sapiens_hsa051691.35344590
26Oocyte meiosis_Homo sapiens_hsa041141.32694961
27Systemic lupus erythematosus_Homo sapiens_hsa053221.30710413
28Acute myeloid leukemia_Homo sapiens_hsa052211.20999082
29Progesterone-mediated oocyte maturation_Homo sapiens_hsa049141.18945406
30* Viral carcinogenesis_Homo sapiens_hsa052031.17207498
31Basal cell carcinoma_Homo sapiens_hsa052171.14543123
32Carbon metabolism_Homo sapiens_hsa012001.09999725
33Purine metabolism_Homo sapiens_hsa002301.07646380
34Antigen processing and presentation_Homo sapiens_hsa046121.05822952
35Colorectal cancer_Homo sapiens_hsa052101.05591942
36HTLV-I infection_Homo sapiens_hsa051661.05527355
37Hippo signaling pathway_Homo sapiens_hsa043901.01140436
38Protein export_Homo sapiens_hsa030601.00618590
39ErbB signaling pathway_Homo sapiens_hsa040120.97890573
402-Oxocarboxylic acid metabolism_Homo sapiens_hsa012100.90554845
41Glycolysis / Gluconeogenesis_Homo sapiens_hsa000100.89584531
42Hedgehog signaling pathway_Homo sapiens_hsa043400.88706171
43Alcoholism_Homo sapiens_hsa050340.88672146
44Glioma_Homo sapiens_hsa052140.88193336
45* MicroRNAs in cancer_Homo sapiens_hsa052060.86536634
46B cell receptor signaling pathway_Homo sapiens_hsa046620.85765449
47Notch signaling pathway_Homo sapiens_hsa043300.84039784
48N-Glycan biosynthesis_Homo sapiens_hsa005100.81886951
49TGF-beta signaling pathway_Homo sapiens_hsa043500.79175773
50* Herpes simplex infection_Homo sapiens_hsa051680.78765179
51Thyroid cancer_Homo sapiens_hsa052160.78336428
52Steroid biosynthesis_Homo sapiens_hsa001000.78283774
53Longevity regulating pathway - multiple species_Homo sapiens_hsa042130.77590515
54Transcriptional misregulation in cancer_Homo sapiens_hsa052020.75724417
55Bacterial invasion of epithelial cells_Homo sapiens_hsa051000.75332510
56Small cell lung cancer_Homo sapiens_hsa052220.75020071
57Lysine degradation_Homo sapiens_hsa003100.73927301
58Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004000.73867953
59Legionellosis_Homo sapiens_hsa051340.73616017
60Protein processing in endoplasmic reticulum_Homo sapiens_hsa041410.72563062
61Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa045500.71641821
62VEGF signaling pathway_Homo sapiens_hsa043700.69468295
63Prolactin signaling pathway_Homo sapiens_hsa049170.66901930
64AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa049330.65419601
65Viral myocarditis_Homo sapiens_hsa054160.64826476
66Primary immunodeficiency_Homo sapiens_hsa053400.64625106
67Salmonella infection_Homo sapiens_hsa051320.62935806
68Choline metabolism in cancer_Homo sapiens_hsa052310.61593581
69Shigellosis_Homo sapiens_hsa051310.61052230
70Vasopressin-regulated water reabsorption_Homo sapiens_hsa049620.60919252
71Chronic myeloid leukemia_Homo sapiens_hsa052200.60614992
72Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010400.59859399
73Prion diseases_Homo sapiens_hsa050200.59750884
74Insulin signaling pathway_Homo sapiens_hsa049100.59512292
75AMPK signaling pathway_Homo sapiens_hsa041520.58754642
76Wnt signaling pathway_Homo sapiens_hsa043100.58590977
77Terpenoid backbone biosynthesis_Homo sapiens_hsa009000.56999611
78Hepatitis B_Homo sapiens_hsa051610.53640233
79Pathways in cancer_Homo sapiens_hsa052000.53045901
80Hepatitis C_Homo sapiens_hsa051600.52080092
81Citrate cycle (TCA cycle)_Homo sapiens_hsa000200.51793569
82Cytosolic DNA-sensing pathway_Homo sapiens_hsa046230.51777190
83Regulation of actin cytoskeleton_Homo sapiens_hsa048100.51011281
84Longevity regulating pathway - mammal_Homo sapiens_hsa042110.50643368
85Adherens junction_Homo sapiens_hsa045200.50580970
86Fructose and mannose metabolism_Homo sapiens_hsa000510.48440392
87Inositol phosphate metabolism_Homo sapiens_hsa005620.47632832
88Gap junction_Homo sapiens_hsa045400.47193825
89Selenocompound metabolism_Homo sapiens_hsa004500.46779160
90Pancreatic cancer_Homo sapiens_hsa052120.45223528
91Estrogen signaling pathway_Homo sapiens_hsa049150.43279600
92Measles_Homo sapiens_hsa051620.42741827
93Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005630.39114901
94Endometrial cancer_Homo sapiens_hsa052130.38922411
95Prostate cancer_Homo sapiens_hsa052150.38372765
96Apoptosis_Homo sapiens_hsa042100.37452213
97Central carbon metabolism in cancer_Homo sapiens_hsa052300.37392356
98T cell receptor signaling pathway_Homo sapiens_hsa046600.36187705
99Proteoglycans in cancer_Homo sapiens_hsa052050.35784841
100Non-small cell lung cancer_Homo sapiens_hsa052230.34714093
101PI3K-Akt signaling pathway_Homo sapiens_hsa041510.33393364
102Tight junction_Homo sapiens_hsa045300.32543850
103Bladder cancer_Homo sapiens_hsa052190.32331627
104Leukocyte transendothelial migration_Homo sapiens_hsa046700.27424909
105Axon guidance_Homo sapiens_hsa043600.27155956
106Biosynthesis of amino acids_Homo sapiens_hsa012300.27139604
107Melanoma_Homo sapiens_hsa052180.27138391
108Type I diabetes mellitus_Homo sapiens_hsa049400.24788331
109Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate_Homo sapiens_hsa005320.22799886
110Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa005200.22163727
111Fc gamma R-mediated phagocytosis_Homo sapiens_hsa046660.21061381
112Other types of O-glycan biosynthesis_Homo sapiens_hsa005140.20763035
113Influenza A_Homo sapiens_hsa051640.20300001
114mTOR signaling pathway_Homo sapiens_hsa041500.20080875
115Neurotrophin signaling pathway_Homo sapiens_hsa047220.20054585
116Thyroid hormone signaling pathway_Homo sapiens_hsa049190.19829396
117Focal adhesion_Homo sapiens_hsa045100.19220416
118HIF-1 signaling pathway_Homo sapiens_hsa040660.17881630
119FoxO signaling pathway_Homo sapiens_hsa040680.17452311
120Renal cell carcinoma_Homo sapiens_hsa052110.16608062
121Hematopoietic cell lineage_Homo sapiens_hsa046400.16565406
122Fc epsilon RI signaling pathway_Homo sapiens_hsa046640.13011227
123Huntingtons disease_Homo sapiens_hsa050160.12896025
124Vibrio cholerae infection_Homo sapiens_hsa051100.12599097
125Natural killer cell mediated cytotoxicity_Homo sapiens_hsa046500.12079348
126Pentose phosphate pathway_Homo sapiens_hsa000300.11742596
127Autoimmune thyroid disease_Homo sapiens_hsa053200.11630820
128Renin-angiotensin system_Homo sapiens_hsa046140.09634204
129NF-kappa B signaling pathway_Homo sapiens_hsa040640.08730275

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