ARCHS4

Functional Annotation Prediction

Predicted biological processes (GO)

Rank	Gene Set	Z-score
1	regulation of single stranded viral RNA replication via double stranded DNA intermediate (GO:0045091	7.56284488
2	DNA deamination (GO:0045006)	7.01560683
3	cytidine metabolic process (GO:0046087)	6.99808783
4	cytidine catabolic process (GO:0006216)	6.99808783
5	cytidine deamination (GO:0009972)	6.99808783
6	Arp2/3 complex-mediated actin nucleation (GO:0034314)	6.95393007
7	actin nucleation (GO:0045010)	6.25476525
8	pyrimidine ribonucleoside catabolic process (GO:0046133)	6.12210471
9	negative T cell selection (GO:0043383)	5.05587450
10	sequestering of actin monomers (GO:0042989)	4.96538897
11	cellular response to interleukin-15 (GO:0071350)	4.56610522
12	positive regulation of natural killer cell mediated immunity (GO:0002717)	4.43601800
13	positive regulation of natural killer cell mediated cytotoxicity (GO:0045954)	4.29825121
14	negative thymic T cell selection (GO:0045060)	4.24709537
15	antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-independent (G	4.17259984
16	positive regulation of leukocyte mediated cytotoxicity (GO:0001912)	4.06302170
17	positive regulation of antigen receptor-mediated signaling pathway (GO:0050857)	3.93055018
18	negative regulation of T cell apoptotic process (GO:0070233)	3.87667249
19	regulation of natural killer cell mediated cytotoxicity (GO:0042269)	3.83454209
20	regulation of natural killer cell mediated immunity (GO:0002715)	3.83454209
21	positive T cell selection (GO:0043368)	3.82708902
22	positive thymic T cell selection (GO:0045059)	3.74276508
23	adaptation of signaling pathway (GO:0023058)	3.73874545
24	positive regulation of defense response to virus by host (GO:0002230)	3.71404135
25	regulation of B cell receptor signaling pathway (GO:0050855)	3.66344007
26	positive regulation of T cell mediated cytotoxicity (GO:0001916)	3.63448225
27	regulation of leukocyte mediated cytotoxicity (GO:0001910)	3.61989472
28	negative regulation of stress fiber assembly (GO:0051497)	3.61187806
29	positive regulation of interleukin-2 biosynthetic process (GO:0045086)	3.58606758
30	positive regulation of cell killing (GO:0031343)	3.53485769
31	mitochondrial electron transport, NADH to ubiquinone (GO:0006120)	3.50604455
32	negative regulation by host of viral transcription (GO:0043922)	3.49628774
33	mitochondrial ATP synthesis coupled proton transport (GO:0042776)	3.47810529
34	thymic T cell selection (GO:0045061)	3.47368064
35	purine deoxyribonucleotide catabolic process (GO:0009155)	3.46222559
36	T cell migration (GO:0072678)	3.44541283
37	regulation of gamma-delta T cell differentiation (GO:0045586)	3.38964156
38	platelet dense granule organization (GO:0060155)	3.37427256
39	positive regulation of alpha-beta T cell proliferation (GO:0046641)	3.33627398
40	response to interleukin-15 (GO:0070672)	3.32377258
41	deoxyribonucleoside monophosphate metabolic process (GO:0009162)	3.30459521
42	energy coupled proton transport, down electrochemical gradient (GO:0015985)	3.29997902
43	ATP synthesis coupled proton transport (GO:0015986)	3.29997902
44	positive regulation of interleukin-8 secretion (GO:2000484)	3.29517049
45	iron-sulfur cluster assembly (GO:0016226)	3.24973065
46	metallo-sulfur cluster assembly (GO:0031163)	3.24973065
47	regulation of cellular amino acid metabolic process (GO:0006521)	3.24596534
48	positive regulation of calcium-mediated signaling (GO:0050850)	3.24410176
49	regulation of cell killing (GO:0031341)	3.19167922
50	regulation of T cell receptor signaling pathway (GO:0050856)	3.18036895
51	regulation of activation of Janus kinase activity (GO:0010533)	3.17751735
52	regulation of T cell mediated cytotoxicity (GO:0001914)	3.14601351
53	regulation of regulatory T cell differentiation (GO:0045589)	3.13872285
54	pyrimidine nucleoside catabolic process (GO:0046135)	3.12433745
55	cytolysis (GO:0019835)	3.05949063
56	antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-dependent (GO:	3.05651366
57	DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest (GO:00	3.03432016
58	T cell receptor signaling pathway (GO:0050852)	3.03403739
59	negative regulation of lymphocyte apoptotic process (GO:0070229)	3.00320706
60	purine deoxyribonucleotide metabolic process (GO:0009151)	2.98770610
61	negative regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051436)	2.98169304
62	RNA splicing, via endonucleolytic cleavage and ligation (GO:0000394)	2.97404048
63	tRNA splicing, via endonucleolytic cleavage and ligation (GO:0006388)	2.97404048
64	protein neddylation (GO:0045116)	2.97365956
65	response to interferon-beta (GO:0035456)	2.97197564
66	water-soluble vitamin biosynthetic process (GO:0042364)	2.94061840
67	negative regulation of actin filament bundle assembly (GO:0032232)	2.94029924
68	signal transduction involved in mitotic G1 DNA damage checkpoint (GO:0072431)	2.92279567
69	intracellular signal transduction involved in G1 DNA damage checkpoint (GO:1902400)	2.92279567
70	regulation of antigen receptor-mediated signaling pathway (GO:0050854)	2.91204396
71	regulation of isotype switching to IgG isotypes (GO:0048302)	2.90969694
72	T cell costimulation (GO:0031295)	2.90849453
73	T cell selection (GO:0045058)	2.90786078
74	negative regulation of viral genome replication (GO:0045071)	2.90741115
75	signal transduction involved in mitotic DNA integrity checkpoint (GO:1902403)	2.90653615
76	signal transduction involved in mitotic DNA damage checkpoint (GO:1902402)	2.90653615
77	signal transduction involved in mitotic cell cycle checkpoint (GO:0072413)	2.90653615
78	cellular defense response (GO:0006968)	2.89428118
79	lymphocyte costimulation (GO:0031294)	2.87319892
80	positive regulation of uterine smooth muscle contraction (GO:0070474)	2.86870725
81	respiratory electron transport chain (GO:0022904)	2.86543449
82	positive regulation of gamma-delta T cell activation (GO:0046645)	2.86174571
83	positive regulation of prostaglandin secretion (GO:0032308)	2.85440005
84	antigen processing and presentation of exogenous peptide antigen via MHC class I (GO:0042590)	2.85419785
85	negative regulation of nitric-oxide synthase activity (GO:0051001)	2.84370058
86	electron transport chain (GO:0022900)	2.84236285
87	protein deneddylation (GO:0000338)	2.83912396
88	negative regulation of mast cell activation (GO:0033004)	2.82884088
89	regulation of interleukin-8 secretion (GO:2000482)	2.82158803
90	regulation of defense response to virus by host (GO:0050691)	2.80809486
91	protein complex biogenesis (GO:0070271)	2.78417231
92	base-excision repair, AP site formation (GO:0006285)	2.77702543
93	deoxyribonucleoside triphosphate metabolic process (GO:0009200)	2.74375416
94	signal transduction involved in DNA damage checkpoint (GO:0072422)	2.74318967
95	signal transduction involved in DNA integrity checkpoint (GO:0072401)	2.74318967
96	negative regulation of oxidoreductase activity (GO:0051354)	2.74007142
97	regulation of interleukin-2 biosynthetic process (GO:0045076)	2.72898918
98	signal transduction involved in cell cycle checkpoint (GO:0072395)	2.72158762
99	mast cell activation (GO:0045576)	2.71154158
100	positive regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051437)	2.69764624

Predicted upstream transcription factors (ChEA)

Rank	Gene Set	Z-score
1	BP1_19119308_ChIP-ChIP_Hs578T_Human	4.61075213
2	NOTCH1_17114293_ChIP-ChIP_T-ALL_Human	4.28718492
3	IRF1_21803131_ChIP-Seq_MONOCYTES_Human	3.65376354
4	IRF8_22096565_ChIP-ChIP_GC-B_Human	3.45853468
5	STAT6_20620947_ChIP-Seq_CD4_POS_T_Human	3.38306671
6	HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse	3.11494825
7	IRF8_22096565_ChIP-ChIP_GC-B_Mouse	3.08394357
8	GABP_17652178_ChIP-ChIP_JURKAT_Human	2.91051524
9	KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human	2.83751466
10	ELF1_17652178_ChIP-ChIP_JURKAT_Human	2.62659755
11	EST1_17652178_ChIP-ChIP_JURKAT_Human	2.52235560
12	SOX9_22984422_ChIP-ChIP_TESTIS_Rat	2.43917064
13	JARID1A_20064375_ChIP-Seq_MESCs_Mouse	2.41505950
14	MYB_26560356_Chip-Seq_TH2_Human	2.32634874
15	VDR_23849224_ChIP-Seq_CD4+_Human	2.31329627
16	HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human	2.26325825
17	ZNF274_21170338_ChIP-Seq_K562_Hela	2.19198998
18	VDR_22108803_ChIP-Seq_LS180_Human	2.18956645
19	SRF_21415370_ChIP-Seq_HL-1_Mouse	2.08237561
20	IRF8_21731497_ChIP-ChIP_J774_Mouse	2.06464157
21	FOXP3_17237761_ChIP-ChIP_TREG_Mouse	2.05697990
22	FOXP3_21729870_ChIP-Seq_TREG_Human	1.96255170
23	RUNX_20019798_ChIP-Seq_JUKART_Human	1.95646561
24	LYL1_20887958_ChIP-Seq_HPC-7_Mouse	1.94247595
25	CHD1_19587682_ChIP-ChIP_MESCs_Mouse	1.92562882
26	RUNX1_20887958_ChIP-Seq_HPC-7_Mouse	1.90947605
27	FLI1_27457419_Chip-Seq_LIVER_Mouse	1.87245333
28	ETS1_20019798_ChIP-Seq_JURKAT_Human	1.82200879
29	GATA3_27048872_Chip-Seq_THYMUS_Human	1.81028489
30	NOTCH1_21737748_ChIP-Seq_TLL_Human	1.75861639
31	FLI1_20887958_ChIP-Seq_HPC-7_Mouse	1.73236471
32	SPI1_22096565_ChIP-ChIP_GC-B_Mouse	1.69764046
33	STAT4_19710469_ChIP-ChIP_TH1__Mouse	1.69381881
34	PAX6_23342162_ChIP-ChIP_BETA-FORBRAIN-LENS_Mouse	1.67086939
35	IGF1R_20145208_ChIP-Seq_DFB_Human	1.63057591
36	GATA3_26560356_Chip-Seq_TH2_Human	1.59098960
37	MYCN_21190229_ChIP-Seq_SHEP-21N_Human	1.55004412
38	RBPJ_21746931_ChIP-Seq_IB4-LCL_Human	1.50295444
39	FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse	1.48512328
40	EBNA2_21746931_ChIP-Seq_IB4-LCL_Human	1.45656666
41	E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse	1.41773144
42	UTX_26944678_Chip-Seq_JUKART_Human	1.35888242
43	TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse	1.33435128
44	PCGF2_27294783_Chip-Seq_ESCs_Mouse	1.33244637
45	AR_20517297_ChIP-Seq_VCAP_Human	1.33239901
46	MYC_18940864_ChIP-ChIP_HL60_Human	1.32298065
47	EZH2_22144423_ChIP-Seq_EOC_Human	1.31449945
48	LMO2_20887958_ChIP-Seq_HPC-7_Mouse	1.30297245
49	PBX1_22567123_ChIP-ChIP_OVCAR3_Human	1.29930684
50	CIITA_25753668_ChIP-Seq_RAJI_Human	1.29609901
51	MYB_26560356_Chip-Seq_TH1_Human	1.28041603
52	STAT6_21828071_ChIP-Seq_BEAS2B_Human	1.26547868
53	TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat	1.25965150
54	RUNX1_17652178_ChIP-ChIP_JURKAT_Human	1.25681166
55	PDX1_19855005_ChIP-ChIP_MIN6_Mouse	1.25448758
56	GATA2_20887958_ChIP-Seq_HPC-7_Mouse	1.24181402
57	TP53_22573176_ChIP-Seq_HFKS_Human	1.23609290
58	BCL6_27268052_Chip-Seq_Bcells_Human	1.22374799
59	ELK1_19687146_ChIP-ChIP_HELA_Human	1.21401269
60	IRF1_19129219_ChIP-ChIP_H3396_Human	1.20266258
61	TAL1_22897851_ChIP-Seq_JUKARTE6-1_Human	1.18493854
62	NANOG_20526341_ChIP-Seq_ESCs_Human	1.17484030
63	HOXB4_20404135_ChIP-ChIP_EML_Mouse	1.13764691
64	PCGF2_27294783_Chip-Seq_NPCs_Mouse	1.12309999
65	CTNNB1_24651522_ChIP-Seq_LGR5+_INTESTINAL_STEM_Human	1.11606145
66	CTBP1_25329375_ChIP-Seq_LNCAP_Human	1.10954328
67	HTT_18923047_ChIP-ChIP_STHdh_Human	1.10912858
68	NCOR_22424771_ChIP-Seq_293T_Human	1.10849312
69	STAT3_20064451_ChIP-Seq_CD4+T_Mouse	1.10840803
70	TAF2_19829295_ChIP-Seq_ESCs_Human	1.10695458
71	ERG_20517297_ChIP-Seq_VCAP_Human	1.10318385
72	GATA3_21878914_ChIP-Seq_MCF-7_Human	1.09610267
73	SPI1_23547873_ChIP-Seq_NB4_Human	1.09315374
74	SOX2_19829295_ChIP-Seq_ESCs_Human	1.05352199
75	NANOG_19829295_ChIP-Seq_ESCs_Human	1.05352199
76	SPI1_22790984_ChIP-Seq_ERYTHROLEUKEMIA_Mouse	1.05005322
77	TAF15_26573619_Chip-Seq_HEK293_Human	1.04510176
78	EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human	1.04403546
79	CEBPA_26348894_ChIP-Seq_LIVER_Mouse	1.04085528
80	AUTS2_25519132_ChIP-Seq_293T-REX_Human	1.03071246
81	ELF1_20517297_ChIP-Seq_JURKAT_Human	1.01767761
82	TAL1_20887958_ChIP-Seq_HPC-7_Mouse	1.00551687
83	POU5F1_18358816_ChIP-ChIP_MESCs_Mouse	1.00335041
84	FLI1_21571218_ChIP-Seq_MEGAKARYOCYTES_Human	0.99496442
85	MYC_19829295_ChIP-Seq_ESCs_Human	0.99233347
86	EWS_26573619_Chip-Seq_HEK293_Human	0.99036819
87	FOXA1_25329375_ChIP-Seq_VCAP_Human	0.98616755
88	FOXA1_27270436_Chip-Seq_PROSTATE_Human	0.98616755
89	GRHL2_25758223_ChIP-Seq_PLACENTA_Mouse	0.95420216
90	P300_27268052_Chip-Seq_Bcells_Human	0.94865212
91	YY1_21170310_ChIP-Seq_MESCs_Mouse	0.94739429
92	NFE2_27457419_Chip-Seq_LIVER_Mouse	0.94405707
93	MAF_26560356_Chip-Seq_TH1_Human	0.93982064
94	FOXA1_21572438_ChIP-Seq_LNCaP_Human	0.93881823
95	EBNA1_20929547_Chip-Seq_RAJI-cells_Human	0.93176106
96	ER_23166858_ChIP-Seq_MCF-7_Human	0.92896252
97	P53_21459846_ChIP-Seq_SAOS-2_Human	0.91535630
98	IRF4_20064451_ChIP-Seq_CD4+T_Mouse	0.90282908
99	CBP_20019798_ChIP-Seq_JUKART_Human	0.90282908
100	GATA3_22897851_ChIP-Seq_JUKARTE6-1_Human	0.90266873

Predicted mouse phenotypes (MGI)

Rank	Gene Set	Z-score
1	MP0005671_abnormal_response_to	5.66585584
2	MP0009785_altered_susceptibility_to	3.33017494
3	MP0003763_abnormal_thymus_physiology	3.03510668
4	MP0001835_abnormal_antigen_presentation	2.76698582
5	MP0002166_altered_tumor_susceptibility	2.38238737
6	MP0001800_abnormal_humoral_immune	2.36311761
7	MP0005000_abnormal_immune_tolerance	2.32707138
8	MP0002148_abnormal_hypersensitivity_rea	2.23137255
9	MP0004147_increased_porphyrin_level	2.22495008
10	MP0003786_premature_aging	2.20377544
11	MP0002420_abnormal_adaptive_immunity	2.18093506
12	MP0005025_abnormal_response_to	2.18059983
13	MP0001819_abnormal_immune_cell	2.12762849
14	MP0003866_abnormal_defecation	2.10291598
15	MP0002723_abnormal_immune_serum	2.06324465
16	MP0002102_abnormal_ear_morphology	2.02888917
17	MP0006072_abnormal_retinal_apoptosis	1.96001611
18	MP0002736_abnormal_nociception_after	1.87936939
19	MP0009333_abnormal_splenocyte_physiolog	1.86365226
20	MP0002452_abnormal_antigen_presenting	1.85647113
21	MP0002006_tumorigenesis	1.82088406
22	MP0000685_abnormal_immune_system	1.81924697
23	MP0008875_abnormal_xenobiotic_pharmacok	1.77280792
24	MP0001790_abnormal_immune_system	1.70801654
25	MP0005387_immune_system_phenotype	1.70801654
26	MP0002398_abnormal_bone_marrow	1.68871341
27	MP0003646_muscle_fatigue	1.68491408
28	MP0000716_abnormal_immune_system	1.64708677
29	MP0008872_abnormal_physiological_respon	1.63863864
30	MP0004145_abnormal_muscle_electrophysio	1.63473016
31	MP0005645_abnormal_hypothalamus_physiol	1.61162550
32	MP0002933_joint_inflammation	1.58355213
33	MP0001968_abnormal_touch/_nociception	1.57879789
34	MP0002277_abnormal_respiratory_mucosa	1.54766172
35	MP0006082_CNS_inflammation	1.53980414
36	MP0000689_abnormal_spleen_morphology	1.49174028
37	MP0005084_abnormal_gallbladder_morpholo	1.48607129
38	MP0005646_abnormal_pituitary_gland	1.45892269
39	MP0005551_abnormal_eye_electrophysiolog	1.43337252
40	MP0002405_respiratory_system_inflammati	1.40503261
41	MP0001905_abnormal_dopamine_level	1.38590953
42	MP0010155_abnormal_intestine_physiology	1.37364235
43	MP0001845_abnormal_inflammatory_respons	1.36679190
44	MP0005253_abnormal_eye_physiology	1.35065332
45	MP0002722_abnormal_immune_system	1.34633295
46	MP0006054_spinal_hemorrhage	1.33936652
47	MP0002429_abnormal_blood_cell	1.32331810
48	MP0001764_abnormal_homeostasis	1.32048976
49	MP0000703_abnormal_thymus_morphology	1.28472226
50	MP0008789_abnormal_olfactory_epithelium	1.26797063
51	MP0003724_increased_susceptibility_to	1.25707548
52	MP0003252_abnormal_bile_duct	1.24632034
53	MP0008877_abnormal_DNA_methylation	1.21971585
54	MP0002876_abnormal_thyroid_physiology	1.21076266
55	MP0001873_stomach_inflammation	1.18557112
56	MP0002419_abnormal_innate_immunity	1.18395491
57	MP0005075_abnormal_melanosome_morpholog	1.16055113
58	MP0002234_abnormal_pharynx_morphology	1.15333475
59	MP0005410_abnormal_fertilization	1.15020953
60	MP0000372_irregular_coat_pigmentation	1.14972185
61	MP0008469_abnormal_protein_level	1.12122542
62	MP0010386_abnormal_urinary_bladder	1.09716303
63	MP0005083_abnormal_biliary_tract	1.09660264
64	MP0001853_heart_inflammation	1.06309002
65	MP0009764_decreased_sensitivity_to	1.05150546
66	MP0002138_abnormal_hepatobiliary_system	1.03502798
67	MP0006036_abnormal_mitochondrial_physio	0.98718043
68	MP0001986_abnormal_taste_sensitivity	0.97390352
69	MP0003045_fibrosis	0.95442558
70	MP0008058_abnormal_DNA_repair	0.93158814
71	MP0002693_abnormal_pancreas_physiology	0.93095583
72	MP0008995_early_reproductive_senescence	0.92719128
73	MP0003436_decreased_susceptibility_to	0.91795452
74	MP0003448_altered_tumor_morphology	0.91215919
75	MP0003806_abnormal_nucleotide_metabolis	0.90856355
76	MP0003011_delayed_dark_adaptation	0.90747659
77	MP0001661_extended_life_span	0.88181650
78	MP0001501_abnormal_sleep_pattern	0.88053210
79	MP0002019_abnormal_tumor_incidence	0.85423766
80	MP0002837_dystrophic_cardiac_calcinosis	0.85120968
81	MP0001765_abnormal_ion_homeostasis	0.84101810
82	MP0002095_abnormal_skin_pigmentation	0.83297446
83	MP0003283_abnormal_digestive_organ	0.81316144
84	MP0009763_increased_sensitivity_to	0.80843178
85	MP0003195_calcinosis	0.80593086
86	MP0006276_abnormal_autonomic_nervous	0.77102598
87	MP0003880_abnormal_central_pattern	0.76825739
88	MP0005636_abnormal_mineral_homeostasis	0.76774077
89	MP0005464_abnormal_platelet_physiology	0.76539940
90	MP0005377_hearing/vestibular/ear_phenot	0.75480894
91	MP0003878_abnormal_ear_physiology	0.75480894
92	MP0004885_abnormal_endolymph	0.74811398
93	MP0009765_abnormal_xenobiotic_induced	0.71663109
94	MP0004134_abnormal_chest_morphology	0.71489079
95	MP0009643_abnormal_urine_homeostasis	0.67393577
96	MP0001542_abnormal_bone_strength	0.65688126
97	MP0009697_abnormal_copulation	0.65657849
98	MP0010094_abnormal_chromosome_stability	0.65255747
99	MP0003137_abnormal_impulse_conducting	0.64815870
100	MP0001119_abnormal_female_reproductive	0.64325638

Predicted human phenotypes

Rank	Gene Set	Z-score
1	IgG deficiency (HP:0004315)	4.97453536
2	Severe combined immunodeficiency (HP:0004430)	4.67540084
3	T lymphocytopenia (HP:0005403)	4.58676769
4	Abnormality of T cell number (HP:0011839)	4.47745572
5	Aplastic anemia (HP:0001915)	4.45428366
6	Increased IgM level (HP:0003496)	3.83870710
7	Hypoproteinemia (HP:0003075)	3.82752369
8	Autoimmune hemolytic anemia (HP:0001890)	3.79782764
9	Mitochondrial inheritance (HP:0001427)	3.79439004
10	Combined immunodeficiency (HP:0005387)	3.72466556
11	Acute necrotizing encephalopathy (HP:0006965)	3.47315223
12	Abnormality of T cells (HP:0002843)	3.44621664
13	Hepatocellular necrosis (HP:0001404)	3.37788694
14	Abolished electroretinogram (ERG) (HP:0000550)	3.37482031
15	Abnormal mitochondria in muscle tissue (HP:0008316)	3.35579065
16	Abnormality of B cell number (HP:0010975)	3.35232199
17	Absent rod-and cone-mediated responses on ERG (HP:0007688)	3.29832627
18	Elevated erythrocyte sedimentation rate (HP:0003565)	3.22353601
19	Congenital stationary night blindness (HP:0007642)	3.21646825
20	Chronic diarrhea (HP:0002028)	3.18301534
21	Increased CSF lactate (HP:0002490)	3.13323798
22	Thyroiditis (HP:0100646)	3.06429081
23	Hepatic necrosis (HP:0002605)	2.97054987
24	B lymphocytopenia (HP:0010976)	2.93316842
25	Decreased electroretinogram (ERG) amplitude (HP:0000654)	2.88905549
26	Pancytopenia (HP:0001876)	2.86229944
27	Abnormality of eosinophils (HP:0001879)	2.82830349
28	Agammaglobulinemia (HP:0004432)	2.77836753
29	Acute encephalopathy (HP:0006846)	2.75744052
30	Renal Fanconi syndrome (HP:0001994)	2.75701255
31	Abnormal rod and cone electroretinograms (HP:0008323)	2.75257935
32	Progressive macrocephaly (HP:0004481)	2.74283469
33	IgM deficiency (HP:0002850)	2.69685240
34	Stomatitis (HP:0010280)	2.66941739
35	Increased intramyocellular lipid droplets (HP:0012240)	2.66893301
36	Abnormality of the prostate (HP:0008775)	2.66196415
37	Autoimmune thrombocytopenia (HP:0001973)	2.65854003
38	Decreased central vision (HP:0007663)	2.64773075
39	Renal cortical cysts (HP:0000803)	2.57242586
40	Pancreatic cysts (HP:0001737)	2.54606038
41	Increased hepatocellular lipid droplets (HP:0006565)	2.54483747
42	Recurrent bronchitis (HP:0002837)	2.46806632
43	Attenuation of retinal blood vessels (HP:0007843)	2.45426137
44	Oral leukoplakia (HP:0002745)	2.38061312
45	3-Methylglutaconic aciduria (HP:0003535)	2.36716117
46	Cerebral edema (HP:0002181)	2.36178143
47	Cerebral palsy (HP:0100021)	2.36125304
48	Optic disc pallor (HP:0000543)	2.29739548
49	Lipid accumulation in hepatocytes (HP:0006561)	2.29664137
50	Respiratory failure (HP:0002878)	2.28309801
51	Type I transferrin isoform profile (HP:0003642)	2.27490221
52	Type 2 muscle fiber atrophy (HP:0003554)	2.26379251
53	Increased muscle lipid content (HP:0009058)	2.25890374
54	Abnormality of T cell physiology (HP:0011840)	2.25831289
55	Methylmalonic aciduria (HP:0012120)	2.25300190
56	Increased serum lactate (HP:0002151)	2.24122483
57	Lymphopenia (HP:0001888)	2.21553045
58	Encephalitis (HP:0002383)	2.21504800
59	Decreased activity of cytochrome C oxidase in muscle tissue (HP:0003688)	2.21362714
60	Methylmalonic acidemia (HP:0002912)	2.19588136
61	Abnormal albumin level (HP:0012116)	2.17030349
62	Hypoalbuminemia (HP:0003073)	2.17030349
63	Chronic mucocutaneous candidiasis (HP:0002728)	2.16627625
64	Recurrent cutaneous fungal infections (HP:0011370)	2.16627625
65	Generalized aminoaciduria (HP:0002909)	2.16548216
66	Abnormality of the renal cortex (HP:0011035)	2.14214599
67	Eosinophilia (HP:0001880)	2.12324182
68	Lactic acidosis (HP:0003128)	2.09066296
69	Abnormality of cells of the lymphoid lineage (HP:0012140)	2.09050781
70	Dicarboxylic aciduria (HP:0003215)	2.08516681
71	Abnormality of dicarboxylic acid metabolism (HP:0010995)	2.08516681
72	Decreased activity of mitochondrial respiratory chain (HP:0008972)	2.08265715
73	Abnormal activity of mitochondrial respiratory chain (HP:0011922)	2.08265715
74	Abnormality of the renal collecting system (HP:0004742)	2.04786095
75	Pancreatic fibrosis (HP:0100732)	2.04106008
76	Muscle abnormality related to mitochondrial dysfunction (HP:0003800)	2.03833174
77	Abnormality of midbrain morphology (HP:0002418)	2.03599992
78	Molar tooth sign on MRI (HP:0002419)	2.03599992
79	Bronchitis (HP:0012387)	1.97909137
80	Joint swelling (HP:0001386)	1.97520328
81	Granulocytopenia (HP:0001913)	1.96886969
82	Pendular nystagmus (HP:0012043)	1.95644083
83	True hermaphroditism (HP:0010459)	1.95579681
84	Aplasia/hypoplasia of the uterus (HP:0008684)	1.95451757
85	Mesangial abnormality (HP:0001966)	1.94828674
86	Keratoconus (HP:0000563)	1.94605444
87	Increased corneal curvature (HP:0100692)	1.94605444
88	Severe visual impairment (HP:0001141)	1.91359913
89	Recurrent fungal infections (HP:0002841)	1.90067825
90	Neonatal respiratory distress (HP:0002643)	1.89623558
91	Meningitis (HP:0001287)	1.88815025
92	Hypoplasia of the thymus (HP:0000778)	1.82478673
93	Constricted visual fields (HP:0001133)	1.82415249
94	Exercise intolerance (HP:0003546)	1.81716107
95	Muscle fiber atrophy (HP:0100295)	1.81432339
96	Hypergammaglobulinemia (HP:0010702)	1.80186816
97	Short tibia (HP:0005736)	1.79480193
98	Leukocytosis (HP:0001974)	1.78541599
99	Colon cancer (HP:0003003)	1.77505926
100	Lethargy (HP:0001254)	1.76369665

Predicted kinase interactions (KEA)

Rank	Gene Set	Z-score
1	TXK	6.28476760
2	KDR	5.74137375
3	TESK2	5.17984317
4	BCKDK	3.08126079
5	TAOK3	2.89069795
6	VRK2	2.36199271
7	MAP4K1	2.31148323
8	TIE1	2.30699009
9	ITK	2.24374656
10	LIMK1	2.21213537
11	TESK1	2.18452308
12	SCYL2	2.13120639
13	MAP4K2	2.12119866
14	STK16	1.86847623
15	ZAK	1.79843652
16	TLK1	1.61874048
17	GRK7	1.59240478
18	VRK1	1.57170944
19	MAP3K12	1.53101664
20	TEC	1.51820622
21	ADRBK2	1.50323750
22	NUAK1	1.48264974
23	GRK1	1.29956721
24	IKBKE	1.27770091
25	NME1	1.22190105
26	FES	1.21743173
27	MAPKAPK3	1.20402461
28	SYK	1.19729266
29	MUSK	1.18520774
30	BCR	1.15880541
31	BUB1	1.15685995
32	DAPK1	1.13043342
33	GRK6	1.09227251
34	TBK1	1.01749933
35	MAP3K11	0.95064364
36	TNK2	0.94161477
37	PRKCQ	0.93414711
38	CSNK1G3	0.92042737
39	LCK	0.89008742
40	KIT	0.84336314
41	CSF1R	0.84103220
42	BTK	0.83390091
43	MAPK13	0.79154583
44	IKBKB	0.77628892
45	LYN	0.76325337
46	INSRR	0.74780783
47	GRK5	0.71930759
48	CSNK1A1L	0.71409882
49	WNK4	0.65310737
50	ERBB3	0.64695147
51	MAP2K7	0.62476321
52	CDK19	0.61624588
53	RPS6KA5	0.59862159
54	TRIM28	0.59696475
55	STK10	0.59066379
56	MYLK	0.57631585
57	RPS6KA4	0.57086567
58	ZAP70	0.56788893
59	OBSCN	0.56537620
60	PASK	0.55092852
61	OXSR1	0.54484018
62	CSK	0.54321645
63	CSNK1G2	0.54061411
64	WNK3	0.52660332
65	CSNK1G1	0.52619901
66	IGF1R	0.52311997
67	EPHA4	0.51787049
68	MST4	0.44898951
69	MAP3K5	0.40878737
70	EIF2AK3	0.40220171
71	PIM1	0.38295500
72	JAK3	0.38028877
73	AURKA	0.37962513
74	PINK1	0.37386761
75	BMPR2	0.37091456
76	FYN	0.36718475
77	PIK3CA	0.36458920
78	PHKG2	0.35701220
79	PHKG1	0.35701220
80	TGFBR2	0.34942468
81	ADRBK1	0.34805328
82	STK39	0.33481256
83	PRKCA	0.31497770
84	MAP2K6	0.30791153
85	MAP3K4	0.30209393
86	ROCK1	0.29755814
87	DAPK2	0.29734953
88	MAPKAPK5	0.29328404
89	ATR	0.28016670
90	FRK	0.27991216
91	CSNK1A1	0.26763994
92	PAK1	0.26759977
93	MAPKAPK2	0.26327983
94	PLK4	0.26276009
95	PRKCD	0.26104918
96	CSNK2A1	0.25811998
97	PRKCH	0.25183421
98	BMPR1B	0.22995453
99	ABL1	0.22822422
100	CAMK2A	0.22401561

Predicted pathways (KEGG)

Rank	Gene Set	Z-score
1	Primary immunodeficiency_Homo sapiens_hsa05340	5.12769074
2	Proteasome_Homo sapiens_hsa03050	4.41634552
3	Oxidative phosphorylation_Homo sapiens_hsa00190	3.27052784
4	Antigen processing and presentation_Homo sapiens_hsa04612	3.03725109
5	Graft-versus-host disease_Homo sapiens_hsa05332	2.78534288
6	Parkinsons disease_Homo sapiens_hsa05012	2.56454199
7	Autoimmune thyroid disease_Homo sapiens_hsa05320	2.51296988
8	Cytosolic DNA-sensing pathway_Homo sapiens_hsa04623	2.42017566
9	Allograft rejection_Homo sapiens_hsa05330	2.37944242
10	Protein export_Homo sapiens_hsa03060	2.15764673
11	Natural killer cell mediated cytotoxicity_Homo sapiens_hsa04650	2.14923734
12	Hematopoietic cell lineage_Homo sapiens_hsa04640	2.02239110
13	Phototransduction_Homo sapiens_hsa04744	2.00963796
14	RNA polymerase_Homo sapiens_hsa03020	1.94515144
15	Type I diabetes mellitus_Homo sapiens_hsa04940	1.85532234
16	Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa00563	1.81992907
17	Intestinal immune network for IgA production_Homo sapiens_hsa04672	1.80559802
18	Alzheimers disease_Homo sapiens_hsa05010	1.70122502
19	Rheumatoid arthritis_Homo sapiens_hsa05323	1.69052584
20	T cell receptor signaling pathway_Homo sapiens_hsa04660	1.67460461
21	Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa04932	1.60758349
22	Huntingtons disease_Homo sapiens_hsa05016	1.47473833
23	Ribosome_Homo sapiens_hsa03010	1.30808115
24	Caffeine metabolism_Homo sapiens_hsa00232	1.24756211
25	Asthma_Homo sapiens_hsa05310	1.23930258
26	Cardiac muscle contraction_Homo sapiens_hsa04260	1.23505722
27	DNA replication_Homo sapiens_hsa03030	1.23078142
28	Pyrimidine metabolism_Homo sapiens_hsa00240	1.21554657
29	Nitrogen metabolism_Homo sapiens_hsa00910	1.20978521
30	One carbon pool by folate_Homo sapiens_hsa00670	1.18504308
31	Shigellosis_Homo sapiens_hsa05131	1.15635467
32	NF-kappa B signaling pathway_Homo sapiens_hsa04064	1.15137558
33	Cell adhesion molecules (CAMs)_Homo sapiens_hsa04514	1.13892324
34	Linoleic acid metabolism_Homo sapiens_hsa00591	1.12222624
35	Homologous recombination_Homo sapiens_hsa03440	1.08752204
36	Pathogenic Escherichia coli infection_Homo sapiens_hsa05130	1.08621167
37	Inflammatory bowel disease (IBD)_Homo sapiens_hsa05321	1.07927337
38	Viral myocarditis_Homo sapiens_hsa05416	1.06679132
39	alpha-Linolenic acid metabolism_Homo sapiens_hsa00592	1.00559110
40	Measles_Homo sapiens_hsa05162	0.99565573
41	Neuroactive ligand-receptor interaction_Homo sapiens_hsa04080	0.99227166
42	Base excision repair_Homo sapiens_hsa03410	0.98618258
43	Purine metabolism_Homo sapiens_hsa00230	0.96754947
44	Cytokine-cytokine receptor interaction_Homo sapiens_hsa04060	0.96607798
45	Systemic lupus erythematosus_Homo sapiens_hsa05322	0.93836084
46	Fanconi anemia pathway_Homo sapiens_hsa03460	0.91852049
47	Porphyrin and chlorophyll metabolism_Homo sapiens_hsa00860	0.91001210
48	RNA degradation_Homo sapiens_hsa03018	0.86545071
49	Salmonella infection_Homo sapiens_hsa05132	0.82444817
50	Peroxisome_Homo sapiens_hsa04146	0.81769176
51	Tryptophan metabolism_Homo sapiens_hsa00380	0.81433353
52	Collecting duct acid secretion_Homo sapiens_hsa04966	0.79716552
53	Nucleotide excision repair_Homo sapiens_hsa03420	0.77645769
54	Steroid hormone biosynthesis_Homo sapiens_hsa00140	0.72098250
55	RIG-I-like receptor signaling pathway_Homo sapiens_hsa04622	0.71498868
56	Malaria_Homo sapiens_hsa05144	0.70492818
57	Mismatch repair_Homo sapiens_hsa03430	0.68940930
58	Arachidonic acid metabolism_Homo sapiens_hsa00590	0.67295669
59	Propanoate metabolism_Homo sapiens_hsa00640	0.66397502
60	Taste transduction_Homo sapiens_hsa04742	0.62835208
61	Ribosome biogenesis in eukaryotes_Homo sapiens_hsa03008	0.60639235
62	Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa00604	0.59609738
63	Valine, leucine and isoleucine degradation_Homo sapiens_hsa00280	0.59551841
64	Nicotinate and nicotinamide metabolism_Homo sapiens_hsa00760	0.59415826
65	Butanoate metabolism_Homo sapiens_hsa00650	0.57012678
66	Chemical carcinogenesis_Homo sapiens_hsa05204	0.56455724
67	Olfactory transduction_Homo sapiens_hsa04740	0.55017952
68	Ether lipid metabolism_Homo sapiens_hsa00565	0.50771957
69	Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa00533	0.48426105
70	Retinol metabolism_Homo sapiens_hsa00830	0.46798919
71	Spliceosome_Homo sapiens_hsa03040	0.46740991
72	Selenocompound metabolism_Homo sapiens_hsa00450	0.46597422
73	Epstein-Barr virus infection_Homo sapiens_hsa05169	0.45333917
74	Drug metabolism - cytochrome P450_Homo sapiens_hsa00982	0.44523410
75	SNARE interactions in vesicular transport_Homo sapiens_hsa04130	0.44381509
76	Fatty acid elongation_Homo sapiens_hsa00062	0.43177640
77	Metabolic pathways_Homo sapiens_hsa01100	0.43133934
78	Maturity onset diabetes of the young_Homo sapiens_hsa04950	0.40857158
79	Herpes simplex infection_Homo sapiens_hsa05168	0.39518896
80	Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa00980	0.38042650
81	Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa00130	0.33699556
82	Staphylococcus aureus infection_Homo sapiens_hsa05150	0.33299687
83	NOD-like receptor signaling pathway_Homo sapiens_hsa04621	0.32907517
84	Regulation of autophagy_Homo sapiens_hsa04140	0.32084552
85	Fc gamma R-mediated phagocytosis_Homo sapiens_hsa04666	0.30116841
86	Glutathione metabolism_Homo sapiens_hsa00480	0.29673941
87	Glycine, serine and threonine metabolism_Homo sapiens_hsa00260	0.29127298
88	N-Glycan biosynthesis_Homo sapiens_hsa00510	0.28519952
89	Salivary secretion_Homo sapiens_hsa04970	0.28399221
90	Nicotine addiction_Homo sapiens_hsa05033	0.27954616
91	Morphine addiction_Homo sapiens_hsa05032	0.27334440
92	Sulfur relay system_Homo sapiens_hsa04122	0.26406896
93	Cysteine and methionine metabolism_Homo sapiens_hsa00270	0.26315131
94	RNA transport_Homo sapiens_hsa03013	0.25634577
95	Pentose and glucuronate interconversions_Homo sapiens_hsa00040	0.23511038
96	Primary bile acid biosynthesis_Homo sapiens_hsa00120	0.23191573
97	Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa00601	0.22256719
98	Legionellosis_Homo sapiens_hsa05134	0.21123742
99	Mucin type O-Glycan biosynthesis_Homo sapiens_hsa00512	0.20299767
100	Drug metabolism - other enzymes_Homo sapiens_hsa00983	0.19785484

HNRNPKP1

Functional Annotation Prediction

Predicted biological processes (GO)

Predicted upstream transcription factors (ChEA)

Predicted mouse phenotypes (MGI)

Predicted human phenotypes

Predicted kinase interactions (KEA)

Predicted pathways (KEGG)

Most similar genes based on co-expression Upload to Enrichr

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