HNRNPKP2

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: No gene information available for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1cytidine metabolic process (GO:0046087)9.24627996
2cytidine catabolic process (GO:0006216)9.24627996
3cytidine deamination (GO:0009972)9.24627996
4regulation of single stranded viral RNA replication via double stranded DNA intermediate (GO:00450919.08248094
5DNA deamination (GO:0045006)8.86908630
6pyrimidine ribonucleoside catabolic process (GO:0046133)8.21316261
7Arp2/3 complex-mediated actin nucleation (GO:0034314)6.77180377
8actin nucleation (GO:0045010)5.94574383
9T cell migration (GO:0072678)4.71485020
10regulation of B cell receptor signaling pathway (GO:0050855)4.69502929
11sequestering of actin monomers (GO:0042989)4.67590565
12cellular response to interleukin-15 (GO:0071350)4.58438674
13negative regulation by host of viral transcription (GO:0043922)4.35614869
14negative T cell selection (GO:0043383)4.29850951
15regulation of regulatory T cell differentiation (GO:0045589)4.24136643
16positive regulation of interleukin-8 secretion (GO:2000484)4.16597565
17positive regulation of antigen receptor-mediated signaling pathway (GO:0050857)4.11596192
18positive regulation of natural killer cell mediated immunity (GO:0002717)4.09192506
19pyrimidine nucleoside catabolic process (GO:0046135)4.03577275
20positive regulation of natural killer cell mediated cytotoxicity (GO:0045954)4.01845067
21negative regulation of T cell apoptotic process (GO:0070233)3.94958283
22positive T cell selection (GO:0043368)3.87061791
23positive regulation of B cell differentiation (GO:0045579)3.86498439
24antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-independent (G3.85290675
25positive regulation of leukocyte mediated cytotoxicity (GO:0001912)3.83557148
26positive thymic T cell selection (GO:0045059)3.79167869
27positive regulation of calcium-mediated signaling (GO:0050850)3.79039913
28positive regulation of gamma-delta T cell activation (GO:0046645)3.74017866
29positive regulation of defense response to virus by host (GO:0002230)3.68262372
30cytolysis (GO:0019835)3.60779933
31negative regulation of viral genome replication (GO:0045071)3.60107417
32regulation of natural killer cell mediated cytotoxicity (GO:0042269)3.58514157
33regulation of natural killer cell mediated immunity (GO:0002715)3.58514157
34regulation of activation of Janus kinase activity (GO:0010533)3.58399775
35regulation of T cell receptor signaling pathway (GO:0050856)3.53040674
36regulation of leukocyte mediated cytotoxicity (GO:0001910)3.52057809
37eosinophil chemotaxis (GO:0048245)3.51257179
38regulation of antigen receptor-mediated signaling pathway (GO:0050854)3.46783485
39negative thymic T cell selection (GO:0045060)3.46767554
40positive regulation of cell killing (GO:0031343)3.45200341
41positive regulation of T cell mediated cytotoxicity (GO:0001916)3.44525758
42protein neddylation (GO:0045116)3.43169610
43response to interleukin-15 (GO:0070672)3.38627934
44regulation of B cell differentiation (GO:0045577)3.37919720
45regulation of gamma-delta T cell differentiation (GO:0045586)3.36556601
46positive regulation of tolerance induction (GO:0002645)3.32492614
47regulation of cellular amino acid metabolic process (GO:0006521)3.29472559
48negative regulation of lipopolysaccharide-mediated signaling pathway (GO:0031665)3.27214413
49T cell receptor signaling pathway (GO:0050852)3.26996879
50negative regulation of antigen receptor-mediated signaling pathway (GO:0050858)3.23506418
51regulation of interleukin-8 secretion (GO:2000482)3.23080309
52regulation of T cell mediated cytotoxicity (GO:0001914)3.22757048
53regulation of cell killing (GO:0031341)3.22748276
54macrophage chemotaxis (GO:0048246)3.22156567
55DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest (GO:003.21676752
56thymic T cell selection (GO:0045061)3.19700489
57eosinophil migration (GO:0072677)3.19351683
58regulation of T cell tolerance induction (GO:0002664)3.17673114
59tRNA splicing, via endonucleolytic cleavage and ligation (GO:0006388)3.17191902
60RNA splicing, via endonucleolytic cleavage and ligation (GO:0000394)3.17191902
61positive regulation of alpha-beta T cell proliferation (GO:0046641)3.14190650
62DNA demethylation (GO:0080111)3.12258874
63intracellular signal transduction involved in G1 DNA damage checkpoint (GO:1902400)3.10726634
64signal transduction involved in mitotic G1 DNA damage checkpoint (GO:0072431)3.10726634
65antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-dependent (GO:3.09175564
66iron-sulfur cluster assembly (GO:0016226)3.09016613
67metallo-sulfur cluster assembly (GO:0031163)3.09016613
68signal transduction involved in mitotic cell cycle checkpoint (GO:0072413)3.08430311
69signal transduction involved in mitotic DNA integrity checkpoint (GO:1902403)3.08430311
70signal transduction involved in mitotic DNA damage checkpoint (GO:1902402)3.08430311
71lymphocyte chemotaxis (GO:0048247)3.07214553
72T cell costimulation (GO:0031295)3.05975928
73negative regulation of stress fiber assembly (GO:0051497)3.03545069
74lymphocyte costimulation (GO:0031294)3.02258015
75positive regulation of interleukin-2 biosynthetic process (GO:0045086)2.95019394
76regulation of chronic inflammatory response (GO:0002676)2.93845039
77negative regulation of B cell proliferation (GO:0030889)2.91540548
78negative regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051436)2.90664945
79signal transduction involved in cell cycle checkpoint (GO:0072395)2.89466463
80signal transduction involved in DNA integrity checkpoint (GO:0072401)2.89183175
81signal transduction involved in DNA damage checkpoint (GO:0072422)2.89183175
82mast cell activation (GO:0045576)2.89120688
83antigen receptor-mediated signaling pathway (GO:0050851)2.88328951
84antigen processing and presentation of exogenous peptide antigen via MHC class I (GO:0042590)2.87766729
85regulation of defense response to virus by host (GO:0050691)2.87325995
86regulation of antigen processing and presentation of peptide antigen (GO:0002583)2.86984978
87negative regulation of lymphocyte apoptotic process (GO:0070229)2.86581899
88T cell selection (GO:0045058)2.86549183
89platelet dense granule organization (GO:0060155)2.85761379
90lymphocyte migration (GO:0072676)2.84669447
91regulation of viral genome replication (GO:0045069)2.81812170
92positive regulation of uterine smooth muscle contraction (GO:0070474)2.79780149
93DNA dealkylation (GO:0035510)2.79456257
94regulation of lymphocyte chemotaxis (GO:1901623)2.79433293
95mast cell activation involved in immune response (GO:0002279)2.79322827
96mast cell degranulation (GO:0043303)2.79322827
97response to interferon-beta (GO:0035456)2.78833585
98negative regulation of T cell receptor signaling pathway (GO:0050860)2.75713741
99pyrimidine-containing compound catabolic process (GO:0072529)2.74521637
100mitochondrial electron transport, NADH to ubiquinone (GO:0006120)2.73486529

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1BP1_19119308_ChIP-ChIP_Hs578T_Human5.70718273
2STAT6_20620947_ChIP-Seq_CD4_POS_T_Human3.88642821
3NOTCH1_17114293_ChIP-ChIP_T-ALL_Human3.83789349
4IRF8_22096565_ChIP-ChIP_GC-B_Human3.65211914
5IRF1_21803131_ChIP-Seq_MONOCYTES_Human3.65114429
6ELF1_17652178_ChIP-ChIP_JURKAT_Human3.60035522
7GABP_17652178_ChIP-ChIP_JURKAT_Human3.06663875
8KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human3.00471399
9FOXP3_17237761_ChIP-ChIP_TREG_Mouse3.00405161
10IRF8_22096565_ChIP-ChIP_GC-B_Mouse2.97231797
11MYB_26560356_Chip-Seq_TH2_Human2.61463002
12EST1_17652178_ChIP-ChIP_JURKAT_Human2.40118241
13VDR_23849224_ChIP-Seq_CD4+_Human2.30090863
14HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human2.28469890
15HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse2.21352326
16JARID1A_20064375_ChIP-Seq_MESCs_Mouse2.19822721
17IGF1R_20145208_ChIP-Seq_DFB_Human2.13964419
18IRF8_21731497_ChIP-ChIP_J774_Mouse2.07239729
19FLI1_27457419_Chip-Seq_LIVER_Mouse1.98575245
20ZNF274_21170338_ChIP-Seq_K562_Hela1.95992977
21SOX9_22984422_ChIP-ChIP_TESTIS_Rat1.93239271
22GATA3_27048872_Chip-Seq_THYMUS_Human1.89652545
23RUNX_20019798_ChIP-Seq_JUKART_Human1.87130164
24LYL1_20887958_ChIP-Seq_HPC-7_Mouse1.86385312
25RUNX1_20887958_ChIP-Seq_HPC-7_Mouse1.85070256
26SPI1_22096565_ChIP-ChIP_GC-B_Mouse1.84608862
27SRF_21415370_ChIP-Seq_HL-1_Mouse1.84481583
28FOXP3_21729870_ChIP-Seq_TREG_Human1.82675106
29STAT4_19710469_ChIP-ChIP_TH1__Mouse1.78782866
30GATA3_26560356_Chip-Seq_TH2_Human1.77618105
31NOTCH1_21737748_ChIP-Seq_TLL_Human1.76002364
32VDR_22108803_ChIP-Seq_LS180_Human1.71627483
33FLI1_20887958_ChIP-Seq_HPC-7_Mouse1.66684424
34ETS1_20019798_ChIP-Seq_JURKAT_Human1.65882901
35CHD1_19587682_ChIP-ChIP_MESCs_Mouse1.63225718
36ELK1_19687146_ChIP-ChIP_HELA_Human1.61060901
37E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse1.58994266
38PCGF2_27294783_Chip-Seq_ESCs_Mouse1.58312057
39MYB_26560356_Chip-Seq_TH1_Human1.48338126
40PCGF2_27294783_Chip-Seq_NPCs_Mouse1.43826292
41MYCN_21190229_ChIP-Seq_SHEP-21N_Human1.39881684
42PAX6_23342162_ChIP-ChIP_BETA-FORBRAIN-LENS_Mouse1.38849603
43CIITA_25753668_ChIP-Seq_RAJI_Human1.35950699
44AR_20517297_ChIP-Seq_VCAP_Human1.33163401
45PBX1_22567123_ChIP-ChIP_OVCAR3_Human1.32419239
46MYC_18940864_ChIP-ChIP_HL60_Human1.31723778
47RBPJ_21746931_ChIP-Seq_IB4-LCL_Human1.28607320
48HTT_18923047_ChIP-ChIP_STHdh_Human1.26383363
49EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human1.23710763
50HOXB4_20404135_ChIP-ChIP_EML_Mouse1.23119288
51EBNA2_21746931_ChIP-Seq_IB4-LCL_Human1.23078263
52STAT3_20064451_ChIP-Seq_CD4+T_Mouse1.22813238
53CTNNB1_24651522_ChIP-Seq_LGR5+_INTESTINAL_STEM_Human1.21941068
54SPI1_22790984_ChIP-Seq_ERYTHROLEUKEMIA_Mouse1.19497668
55TP53_22573176_ChIP-Seq_HFKS_Human1.19040549
56RUNX1_17652178_ChIP-ChIP_JURKAT_Human1.17794507
57TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.16480513
58FOXA1_27270436_Chip-Seq_PROSTATE_Human1.16347548
59FOXA1_25329375_ChIP-Seq_VCAP_Human1.16347548
60NCOR_22424771_ChIP-Seq_293T_Human1.15926541
61NFE2_27457419_Chip-Seq_LIVER_Mouse1.15285753
62TAL1_22897851_ChIP-Seq_JUKARTE6-1_Human1.14308000
63LMO2_20887958_ChIP-Seq_HPC-7_Mouse1.14090199
64FOXA1_21572438_ChIP-Seq_LNCaP_Human1.13896079
65UTX_26944678_Chip-Seq_JUKART_Human1.12439515
66BCL6_27268052_Chip-Seq_Bcells_Human1.10938715
67TAF2_19829295_ChIP-Seq_ESCs_Human1.08976703
68MEIS1_20887958_ChIP-Seq_HPC-7_Mouse1.08898231
69SPI1_23547873_ChIP-Seq_NB4_Human1.08073659
70CREB1_15753290_ChIP-ChIP_HEK293T_Human1.07982143
71NANOG_20526341_ChIP-Seq_ESCs_Human1.07745672
72FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse1.07146577
73FOXO1_25302145_ChIP-Seq_T-LYMPHOCYTE_Mouse1.06854172
74IRF1_19129219_ChIP-ChIP_H3396_Human1.03233910
75GATA2_20887958_ChIP-Seq_HPC-7_Mouse1.03137596
76ERG_20517297_ChIP-Seq_VCAP_Human1.00864192
77MYC_19829295_ChIP-Seq_ESCs_Human1.00025406
78CIITA_18437201_ChIP-ChIP_Raji_B_and_iDC_Human0.99783826
79MYC_20876797_ChIP-ChIP_MEDULLOBLASTOMA_Human0.99617683
80SOX2_19829295_ChIP-Seq_ESCs_Human0.99271358
81NANOG_19829295_ChIP-Seq_ESCs_Human0.99271358
82FLI1_21571218_ChIP-Seq_MEGAKARYOCYTES_Human0.99221714
83SUZ12_27294783_Chip-Seq_NPCs_Mouse0.99135296
84EZH2_27294783_Chip-Seq_NPCs_Mouse0.98846966
85ER_23166858_ChIP-Seq_MCF-7_Human0.97437482
86ELK1_22589737_ChIP-Seq_MCF10A_Human0.96853307
87PDX1_19855005_ChIP-ChIP_MIN6_Mouse0.96525903
88POU3F2_20337985_ChIP-ChIP_501MEL_Human0.95413276
89MAF_26560356_Chip-Seq_TH2_Human0.95284332
90TAL1_20887958_ChIP-Seq_HPC-7_Mouse0.95197658
91GATA3_26560356_Chip-Seq_TH1_Human0.94486285
92GATA3_21878914_ChIP-Seq_MCF-7_Human0.93651380
93GATA6_21074721_ChIP-Seq_CACO-2_Mouse0.93454503
94MAF_26560356_Chip-Seq_TH1_Human0.92922279
95MECOM_23826213_ChIP-Seq_KASUMI_Mouse0.92750057
96POU5F1_16153702_ChIP-ChIP_HESCs_Human0.92693679
97CEBPB_23403033_ChIP-Seq_LIVER_Mouse0.91570239
98YY1_21170310_ChIP-Seq_MESCs_Mouse0.90918727
99EBNA1_20929547_Chip-Seq_RAJI-cells_Human0.89300787
100EZH2_22144423_ChIP-Seq_EOC_Human0.89073313

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0005671_abnormal_response_to6.29535980
2MP0009785_altered_susceptibility_to3.39907283
3MP0003763_abnormal_thymus_physiology3.24470868
4MP0002102_abnormal_ear_morphology2.82366790
5MP0001835_abnormal_antigen_presentation2.80773750
6MP0002166_altered_tumor_susceptibility2.61784967
7MP0005000_abnormal_immune_tolerance2.41473994
8MP0001800_abnormal_humoral_immune2.37961583
9MP0009333_abnormal_splenocyte_physiolog2.33106070
10MP0004147_increased_porphyrin_level2.26156443
11MP0002148_abnormal_hypersensitivity_rea2.19905463
12MP0005025_abnormal_response_to2.19007301
13MP0002723_abnormal_immune_serum2.18604248
14MP0002420_abnormal_adaptive_immunity2.18091331
15MP0001819_abnormal_immune_cell2.12972569
16MP0003866_abnormal_defecation2.10482158
17MP0002006_tumorigenesis2.07927893
18MP0006072_abnormal_retinal_apoptosis2.03002360
19MP0006082_CNS_inflammation1.98391628
20MP0003786_premature_aging1.93349477
21MP0002452_abnormal_antigen_presenting1.84110289
22MP0005387_immune_system_phenotype1.76951731
23MP0001790_abnormal_immune_system1.76951731
24MP0001873_stomach_inflammation1.75331590
25MP0002933_joint_inflammation1.72685476
26MP0002398_abnormal_bone_marrow1.68546577
27MP0000716_abnormal_immune_system1.67693042
28MP0000372_irregular_coat_pigmentation1.63271701
29MP0005075_abnormal_melanosome_morpholog1.60312038
30MP0002736_abnormal_nociception_after1.58470504
31MP0002405_respiratory_system_inflammati1.57057601
32MP0000703_abnormal_thymus_morphology1.56213298
33MP0000685_abnormal_immune_system1.53493890
34MP0000689_abnormal_spleen_morphology1.51924536
35MP0002722_abnormal_immune_system1.44389686
36MP0003045_fibrosis1.44383159
37MP0003724_increased_susceptibility_to1.43503673
38MP0010155_abnormal_intestine_physiology1.39849317
39MP0001845_abnormal_inflammatory_respons1.39486746
40MP0005645_abnormal_hypothalamus_physiol1.36109834
41MP0003878_abnormal_ear_physiology1.33241063
42MP0005377_hearing/vestibular/ear_phenot1.33241063
43MP0001968_abnormal_touch/_nociception1.33056709
44MP0005253_abnormal_eye_physiology1.31334995
45MP0004145_abnormal_muscle_electrophysio1.30638158
46MP0008789_abnormal_olfactory_epithelium1.27835513
47MP0002429_abnormal_blood_cell1.27479573
48MP0001905_abnormal_dopamine_level1.22915317
49MP0005551_abnormal_eye_electrophysiolog1.19013596
50MP0003448_altered_tumor_morphology1.18298316
51MP0008872_abnormal_physiological_respon1.17632397
52MP0001853_heart_inflammation1.17394719
53MP0003436_decreased_susceptibility_to1.16448355
54MP0001919_abnormal_reproductive_system1.14586033
55MP0002419_abnormal_innate_immunity1.14452105
56MP0002277_abnormal_respiratory_mucosa1.14321996
57MP0009764_decreased_sensitivity_to1.09732539
58MP0005410_abnormal_fertilization1.05440161
59MP0008877_abnormal_DNA_methylation1.03169794
60MP0009763_increased_sensitivity_to1.02489074
61MP0001984_abnormal_olfaction1.00767386
62MP0008469_abnormal_protein_level1.00262956
63MP0003646_muscle_fatigue0.98981001
64MP0008995_early_reproductive_senescence0.97574595
65MP0003137_abnormal_impulse_conducting0.94589295
66MP0006036_abnormal_mitochondrial_physio0.94012941
67MP0005389_reproductive_system_phenotype0.93800577
68MP0008875_abnormal_xenobiotic_pharmacok0.92961067
69MP0002653_abnormal_ependyma_morphology0.91996877
70MP0003806_abnormal_nucleotide_metabolis0.88643704
71MP0005464_abnormal_platelet_physiology0.88004868
72MP0005167_abnormal_blood-brain_barrier0.85623696
73MP0002876_abnormal_thyroid_physiology0.85259760
74MP0009765_abnormal_xenobiotic_induced0.83624941
75MP0003011_delayed_dark_adaptation0.83444838
76MP0002009_preneoplasia0.83160866
77MP0002163_abnormal_gland_morphology0.83048382
78MP0010386_abnormal_urinary_bladder0.82471148
79MP0002234_abnormal_pharynx_morphology0.80832216
80MP0006276_abnormal_autonomic_nervous0.79836726
81MP0002019_abnormal_tumor_incidence0.79087345
82MP0001986_abnormal_taste_sensitivity0.79052350
83MP0001764_abnormal_homeostasis0.78183784
84MP0005499_abnormal_olfactory_system0.76615195
85MP0005394_taste/olfaction_phenotype0.76615195
86MP0003252_abnormal_bile_duct0.76220524
87MP0005084_abnormal_gallbladder_morpholo0.75927899
88MP0005646_abnormal_pituitary_gland0.75853033
89MP0006054_spinal_hemorrhage0.75672684
90MP0001485_abnormal_pinna_reflex0.73662730
91MP0000465_gastrointestinal_hemorrhage0.72150387
92MP0004885_abnormal_endolymph0.72113715
93MP0001501_abnormal_sleep_pattern0.71713796
94MP0001188_hyperpigmentation0.71093108
95MP0005360_urolithiasis0.71007373
96MP0001529_abnormal_vocalization0.68661104
97MP0001542_abnormal_bone_strength0.68361268
98MP0002095_abnormal_skin_pigmentation0.68186249
99MP0004043_abnormal_pH_regulation0.66384589
100MP0001119_abnormal_female_reproductive0.65218635

Predicted human phenotypes

RankGene SetZ-score
1T lymphocytopenia (HP:0005403)5.81829373
2Abnormality of T cell number (HP:0011839)5.50757245
3Aplastic anemia (HP:0001915)5.26862716
4IgG deficiency (HP:0004315)4.67566528
5Severe combined immunodeficiency (HP:0004430)4.45499370
6Hypoproteinemia (HP:0003075)4.16746897
7Abnormality of T cells (HP:0002843)3.98529911
8Abnormality of the prostate (HP:0008775)3.89654148
9Autoimmune hemolytic anemia (HP:0001890)3.82405682
10Elevated erythrocyte sedimentation rate (HP:0003565)3.67412804
11Combined immunodeficiency (HP:0005387)3.48668646
12Thyroiditis (HP:0100646)3.30886379
13Chronic diarrhea (HP:0002028)3.28123032
14Mitochondrial inheritance (HP:0001427)3.26901779
15Hepatocellular necrosis (HP:0001404)3.18354405
16Increased IgM level (HP:0003496)3.18321264
17Abnormality of eosinophils (HP:0001879)3.16518636
18Increased intramyocellular lipid droplets (HP:0012240)3.02228396
19Pancytopenia (HP:0001876)2.94959249
20Abnormality of B cell number (HP:0010975)2.89383288
21Abolished electroretinogram (ERG) (HP:0000550)2.87870311
223-Methylglutaconic aciduria (HP:0003535)2.83958005
23Renal cortical cysts (HP:0000803)2.83941565
24Renal Fanconi syndrome (HP:0001994)2.82147709
25Acute necrotizing encephalopathy (HP:0006965)2.81791180
26Hepatic necrosis (HP:0002605)2.80664820
27Abnormal mitochondria in muscle tissue (HP:0008316)2.79614905
28Stomatitis (HP:0010280)2.75430048
29IgM deficiency (HP:0002850)2.69332772
30Increased CSF lactate (HP:0002490)2.66432273
31Decreased activity of mitochondrial respiratory chain (HP:0008972)2.64030874
32Abnormal activity of mitochondrial respiratory chain (HP:0011922)2.64030874
33Oral leukoplakia (HP:0002745)2.63736104
34Increased hepatocellular lipid droplets (HP:0006565)2.63422064
35Abnormal delayed hypersensitivity skin test (HP:0002963)2.63231862
36Lymphopenia (HP:0001888)2.55777071
37Amyotrophic lateral sclerosis (HP:0007354)2.53901389
38Absent rod-and cone-mediated responses on ERG (HP:0007688)2.51476817
39Encephalitis (HP:0002383)2.50818085
40Pancreatic cysts (HP:0001737)2.46093113
41B lymphocytopenia (HP:0010976)2.45560708
42Increased muscle lipid content (HP:0009058)2.42907994
43Recurrent bronchitis (HP:0002837)2.42227540
44Congenital stationary night blindness (HP:0007642)2.39615830
45Abnormality of cells of the lymphoid lineage (HP:0012140)2.38626659
46Ureteral stenosis (HP:0000071)2.32835587
47Abnormality of male internal genitalia (HP:0000022)2.31719390
48Generalized aminoaciduria (HP:0002909)2.31683887
49Chronic obstructive pulmonary disease (HP:0006510)2.31439381
50Obstructive lung disease (HP:0006536)2.31439381
51Progressive macrocephaly (HP:0004481)2.31208704
52Abnormality of T cell physiology (HP:0011840)2.31032055
53Lipid accumulation in hepatocytes (HP:0006561)2.26719549
54Autoimmune thrombocytopenia (HP:0001973)2.24396750
55Type I transferrin isoform profile (HP:0003642)2.24293822
56Pulmonary fibrosis (HP:0002206)2.22557987
57Hypoalbuminemia (HP:0003073)2.22218765
58Abnormal albumin level (HP:0012116)2.22218765
59Eosinophilia (HP:0001880)2.21396647
60Chronic mucocutaneous candidiasis (HP:0002728)2.20765122
61Recurrent cutaneous fungal infections (HP:0011370)2.20765122
62Abnormality of the renal cortex (HP:0011035)2.20013742
63Acute encephalopathy (HP:0006846)2.18292747
64Gangrene (HP:0100758)2.18012146
65Ureteral obstruction (HP:0006000)2.17746077
66Meningitis (HP:0001287)2.17089449
67Chest pain (HP:0100749)2.14415699
68Retinal dysplasia (HP:0007973)2.12563385
69Lymphoma (HP:0002665)2.11762184
70Abnormality of midbrain morphology (HP:0002418)2.09075732
71Molar tooth sign on MRI (HP:0002419)2.09075732
72Panhypogammaglobulinemia (HP:0003139)2.05138609
73Pancreatic fibrosis (HP:0100732)2.03468854
74Vasculitis (HP:0002633)2.03374876
75Increased serum lactate (HP:0002151)2.02762153
76True hermaphroditism (HP:0010459)2.02472830
77Joint swelling (HP:0001386)2.00621478
78Pulmonary infiltrates (HP:0002113)2.00423680
79Decreased electroretinogram (ERG) amplitude (HP:0000654)2.00417583
80Leukocytosis (HP:0001974)1.99023009
81Abnormal rod and cone electroretinograms (HP:0008323)1.98657558
82Medial flaring of the eyebrow (HP:0010747)1.96363889
83Methylmalonic acidemia (HP:0002912)1.95546549
84Attenuation of retinal blood vessels (HP:0007843)1.94485294
85Muscle abnormality related to mitochondrial dysfunction (HP:0003800)1.93448401
86Optic disc pallor (HP:0000543)1.90707169
87Type 2 muscle fiber atrophy (HP:0003554)1.88954085
88Gastrointestinal infarctions (HP:0005244)1.88632109
89Bronchitis (HP:0012387)1.87252072
90Lactic acidosis (HP:0003128)1.84715881
91Methylmalonic aciduria (HP:0012120)1.84264976
92Aplasia/hypoplasia of the uterus (HP:0008684)1.83769455
93Myositis (HP:0100614)1.83141439
94Neonatal respiratory distress (HP:0002643)1.82227266
95Prostate neoplasm (HP:0100787)1.82211571
96Decreased activity of cytochrome C oxidase in muscle tissue (HP:0003688)1.81227615
97Recurrent viral infections (HP:0004429)1.80978353
98Cerebral edema (HP:0002181)1.79423415
99Granulocytopenia (HP:0001913)1.79064192
100Type II lissencephaly (HP:0007260)1.78926109

Predicted kinase interactions (KEA)

RankGene SetZ-score
1TXK6.81889402
2KDR5.18022087
3TESK24.53892093
4TAOK33.10467677
5MAP4K12.74148939
6MAP4K22.42972363
7ITK2.33791546
8BCKDK2.23507835
9VRK22.04832265
10TESK12.03219385
11LIMK12.00854385
12SCYL21.93750482
13ADRBK21.92164546
14FES1.67501392
15STK161.61720475
16TEC1.60823034
17BCR1.60062813
18GRK11.54292914
19BUB11.54280120
20TIE11.48998066
21SYK1.41982773
22TLK11.41152150
23ZAK1.36932939
24GRK61.36676744
25VRK11.33195095
26IKBKE1.27611800
27TBK11.21986423
28TRIM281.13628842
29MAP3K121.10654789
30LCK1.10087037
31MST41.08746869
32BTK1.06880156
33IKBKB1.04560608
34PRKCQ1.03169697
35GRK70.96723720
36CSK0.96188999
37NUAK10.95847232
38RPS6KA40.87847156
39CSF1R0.87374641
40MAPKAPK30.86818996
41DAPK10.86591759
42ZAP700.86367762
43LYN0.85339603
44CSNK1G30.83180550
45ERBB30.79818247
46MAP2K70.77549326
47MAP3K110.76693463
48MATK0.75966349
49FRK0.75332859
50CAMKK20.75070136
51MAP2K60.73010725
52WNK40.72773245
53KIT0.72635684
54MAPK130.70160955
55SRPK10.68337801
56EIF2AK30.67692816
57TNK20.66365376
58BMPR1B0.65829602
59BMPR20.63626700
60INSRR0.62733054
61WNK30.58486722
62CSNK1A1L0.57562571
63PASK0.57107723
64CDK190.56758117
65CSNK1G20.56348607
66IGF1R0.55385032
67RPS6KA50.55338777
68OXSR10.52859413
69MYLK0.52686310
70RIPK40.51431651
71PIK3CG0.50320247
72FYN0.49582130
73OBSCN0.49085840
74CSNK1G10.48771137
75MAP3K140.45420183
76GRK50.44977467
77JAK30.38048811
78PIM10.35582053
79MAP3K40.34405167
80PRKCA0.33384113
81MAP3K50.33118768
82ABL10.32630144
83STK390.31955048
84AURKA0.31536871
85INSR0.30834545
86PIM20.30587102
87EIF2AK20.30157119
88ATR0.28751509
89CSNK2A10.27887637
90PRKACA0.26381419
91PIK3CA0.23862139
92CAMK2A0.23551364
93CAMKK10.23336881
94BLK0.23024731
95PLK20.22900408
96NME10.22841151
97ROCK10.22800260
98CCNB10.22153325
99MAPKAPK20.21825347
100PINK10.21792081

Predicted pathways (KEGG)

RankGene SetZ-score
1Primary immunodeficiency_Homo sapiens_hsa053405.60922354
2Proteasome_Homo sapiens_hsa030504.80352765
3Antigen processing and presentation_Homo sapiens_hsa046123.14155903
4Graft-versus-host disease_Homo sapiens_hsa053323.05475702
5Oxidative phosphorylation_Homo sapiens_hsa001902.94416181
6Autoimmune thyroid disease_Homo sapiens_hsa053202.79241665
7Cytosolic DNA-sensing pathway_Homo sapiens_hsa046232.61329813
8Hematopoietic cell lineage_Homo sapiens_hsa046402.50108344
9Parkinsons disease_Homo sapiens_hsa050122.46910940
10Allograft rejection_Homo sapiens_hsa053302.42771025
11Natural killer cell mediated cytotoxicity_Homo sapiens_hsa046502.29091420
12Protein export_Homo sapiens_hsa030602.24638429
13T cell receptor signaling pathway_Homo sapiens_hsa046602.19154874
14Type I diabetes mellitus_Homo sapiens_hsa049401.92461107
15Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005631.82251009
16RNA polymerase_Homo sapiens_hsa030201.78807238
17Rheumatoid arthritis_Homo sapiens_hsa053231.78393027
18Alzheimers disease_Homo sapiens_hsa050101.50538026
19Intestinal immune network for IgA production_Homo sapiens_hsa046721.43871940
20Phototransduction_Homo sapiens_hsa047441.42352386
21NF-kappa B signaling pathway_Homo sapiens_hsa040641.38475363
22Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049321.36689771
23Huntingtons disease_Homo sapiens_hsa050161.31195551
24Cytokine-cytokine receptor interaction_Homo sapiens_hsa040601.31155212
25Homologous recombination_Homo sapiens_hsa034401.25205370
26Cell adhesion molecules (CAMs)_Homo sapiens_hsa045141.15751228
27Shigellosis_Homo sapiens_hsa051311.15613233
28Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006041.09963957
29Measles_Homo sapiens_hsa051621.09447862
30Viral myocarditis_Homo sapiens_hsa054161.09360652
31Nitrogen metabolism_Homo sapiens_hsa009101.08947962
32Pathogenic Escherichia coli infection_Homo sapiens_hsa051301.08038214
33Salmonella infection_Homo sapiens_hsa051321.05590754
34Asthma_Homo sapiens_hsa053101.03841293
35Cardiac muscle contraction_Homo sapiens_hsa042600.99850994
36Inflammatory bowel disease (IBD)_Homo sapiens_hsa053210.99683912
37RIG-I-like receptor signaling pathway_Homo sapiens_hsa046220.99610580
38Neuroactive ligand-receptor interaction_Homo sapiens_hsa040800.98587567
39Peroxisome_Homo sapiens_hsa041460.92673319
40Synthesis and degradation of ketone bodies_Homo sapiens_hsa000720.89140375
41Linoleic acid metabolism_Homo sapiens_hsa005910.88299660
42Caffeine metabolism_Homo sapiens_hsa002320.86968030
43alpha-Linolenic acid metabolism_Homo sapiens_hsa005920.86648029
44Pyrimidine metabolism_Homo sapiens_hsa002400.85255667
45Fanconi anemia pathway_Homo sapiens_hsa034600.83282125
46DNA replication_Homo sapiens_hsa030300.82658305
47Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008600.82540758
48NOD-like receptor signaling pathway_Homo sapiens_hsa046210.80455229
49Collecting duct acid secretion_Homo sapiens_hsa049660.76691178
50Spliceosome_Homo sapiens_hsa030400.75967405
51Olfactory transduction_Homo sapiens_hsa047400.69716873
52Base excision repair_Homo sapiens_hsa034100.68533194
53Purine metabolism_Homo sapiens_hsa002300.68379531
54Butanoate metabolism_Homo sapiens_hsa006500.68363300
55Systemic lupus erythematosus_Homo sapiens_hsa053220.68127944
56Nucleotide excision repair_Homo sapiens_hsa034200.67281523
57Ribosome_Homo sapiens_hsa030100.66428153
58Retinol metabolism_Homo sapiens_hsa008300.61563155
59Steroid hormone biosynthesis_Homo sapiens_hsa001400.57997344
60SNARE interactions in vesicular transport_Homo sapiens_hsa041300.57281411
61Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007600.57211909
62Mismatch repair_Homo sapiens_hsa034300.57017239
63Propanoate metabolism_Homo sapiens_hsa006400.56879114
64Basal transcription factors_Homo sapiens_hsa030220.56741668
65Valine, leucine and isoleucine degradation_Homo sapiens_hsa002800.55615788
66RNA degradation_Homo sapiens_hsa030180.53810689
67Chemical carcinogenesis_Homo sapiens_hsa052040.52406290
68Regulation of autophagy_Homo sapiens_hsa041400.52379525
69Herpes simplex infection_Homo sapiens_hsa051680.52343405
70Glycine, serine and threonine metabolism_Homo sapiens_hsa002600.51645250
71Malaria_Homo sapiens_hsa051440.51353423
72Non-homologous end-joining_Homo sapiens_hsa034500.49046388
73One carbon pool by folate_Homo sapiens_hsa006700.45705451
74Epstein-Barr virus infection_Homo sapiens_hsa051690.45674439
75Tryptophan metabolism_Homo sapiens_hsa003800.44218585
76Arachidonic acid metabolism_Homo sapiens_hsa005900.42657022
77Drug metabolism - cytochrome P450_Homo sapiens_hsa009820.41856422
78Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030080.41801628
79Legionellosis_Homo sapiens_hsa051340.41730120
80Toll-like receptor signaling pathway_Homo sapiens_hsa046200.41576868
81Ether lipid metabolism_Homo sapiens_hsa005650.39377086
82Taste transduction_Homo sapiens_hsa047420.39308745
83Metabolic pathways_Homo sapiens_hsa011000.37332891
84Chagas disease (American trypanosomiasis)_Homo sapiens_hsa051420.36025656
85Ascorbate and aldarate metabolism_Homo sapiens_hsa000530.35312345
86Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009800.33495255
87Nicotine addiction_Homo sapiens_hsa050330.32489936
88Drug metabolism - other enzymes_Homo sapiens_hsa009830.30463624
89Pentose and glucuronate interconversions_Homo sapiens_hsa000400.29348560
90Staphylococcus aureus infection_Homo sapiens_hsa051500.28578896
91Primary bile acid biosynthesis_Homo sapiens_hsa001200.27516469
92Selenocompound metabolism_Homo sapiens_hsa004500.26984538
93Terpenoid backbone biosynthesis_Homo sapiens_hsa009000.26296091
94Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001300.25785474
95Pertussis_Homo sapiens_hsa051330.25756207
96Fc gamma R-mediated phagocytosis_Homo sapiens_hsa046660.25311632
97Chemokine signaling pathway_Homo sapiens_hsa040620.25140552
98RNA transport_Homo sapiens_hsa030130.24464244
99Fatty acid elongation_Homo sapiens_hsa000620.24155650
100Morphine addiction_Homo sapiens_hsa050320.23900745

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