ARCHS4

Functional Annotation Prediction

Predicted biological processes (GO)

Rank	Gene Set	Z-score
1	cornea development in camera-type eye (GO:0061303)	6.08288700
2	hindbrain development (GO:0030902)	5.32620260
3	sequestering of actin monomers (GO:0042989)	4.91717522
4	positive regulation of cell fate commitment (GO:0010455)	4.70678881
5	behavioral response to nicotine (GO:0035095)	4.66202855
6	water-soluble vitamin biosynthetic process (GO:0042364)	4.43240502
7	DNA deamination (GO:0045006)	4.39251079
8	regulation of timing of cell differentiation (GO:0048505)	4.37752093
9	regulation of penile erection (GO:0060405)	4.28236030
10	regulation of development, heterochronic (GO:0040034)	4.15269577
11	RNA destabilization (GO:0050779)	4.01727157
12	negative regulation of transcription elongation from RNA polymerase II promoter (GO:0034244)	3.89155067
13	photoreceptor cell development (GO:0042461)	3.84547411
14	endoderm formation (GO:0001706)	3.56042957
15	positive regulation of defense response to virus by host (GO:0002230)	3.51142863
16	short-term memory (GO:0007614)	3.49527421
17	neuronal action potential propagation (GO:0019227)	3.48721779
18	cellular response to ATP (GO:0071318)	3.46799062
19	ATP synthesis coupled proton transport (GO:0015986)	3.37872274
20	energy coupled proton transport, down electrochemical gradient (GO:0015985)	3.37872274
21	behavioral response to ethanol (GO:0048149)	3.36715611
22	protein neddylation (GO:0045116)	3.36659769
23	RNA splicing, via endonucleolytic cleavage and ligation (GO:0000394)	3.33526925
24	tRNA splicing, via endonucleolytic cleavage and ligation (GO:0006388)	3.33526925
25	regulation of single stranded viral RNA replication via double stranded DNA intermediate (GO:0045091	3.33489890
26	positive regulation of oligodendrocyte differentiation (GO:0048714)	3.32693458
27	regulation of cilium movement (GO:0003352)	3.25598163
28	L-methionine biosynthetic process from methylthioadenosine (GO:0019509)	3.25054457
29	protein prenylation (GO:0018342)	3.01210758
30	prenylation (GO:0097354)	3.01210758
31	astrocyte differentiation (GO:0048708)	3.00805447
32	histone H2A acetylation (GO:0043968)	3.00629148
33	eye photoreceptor cell development (GO:0042462)	3.00161990
34	protein peptidyl-prolyl isomerization (GO:0000413)	2.99828077
35	base-excision repair, AP site formation (GO:0006285)	2.96609652
36	negative regulation of mast cell activation (GO:0033004)	2.93477707
37	mast cell activation involved in immune response (GO:0002279)	2.92721061
38	mast cell degranulation (GO:0043303)	2.92721061
39	regulation of sarcomere organization (GO:0060297)	2.92127817
40	detection of light stimulus involved in visual perception (GO:0050908)	2.87278474
41	detection of light stimulus involved in sensory perception (GO:0050962)	2.87278474
42	epithelial cilium movement involved in determination of left/right asymmetry (GO:0060287)	2.82978600
43	nuclear-transcribed mRNA catabolic process, exonucleolytic (GO:0000291)	2.81890670
44	L-fucose catabolic process (GO:0042355)	2.81817188
45	fucose catabolic process (GO:0019317)	2.81817188
46	L-fucose metabolic process (GO:0042354)	2.81817188
47	L-methionine salvage (GO:0071267)	2.80638876
48	L-methionine biosynthetic process (GO:0071265)	2.80638876
49	amino acid salvage (GO:0043102)	2.80638876
50	regulation of defense response to virus by host (GO:0050691)	2.79623109
51	cilium morphogenesis (GO:0060271)	2.79544124
52	negative regulation of DNA-templated transcription, elongation (GO:0032785)	2.79248249
53	adenosine metabolic process (GO:0046085)	2.78832663
54	histone H2A monoubiquitination (GO:0035518)	2.77983792
55	epithelial cilium movement (GO:0003351)	2.75764188
56	cilium or flagellum-dependent cell motility (GO:0001539)	2.75601363
57	lymphangiogenesis (GO:0001946)	2.75474036
58	metallo-sulfur cluster assembly (GO:0031163)	2.72121228
59	iron-sulfur cluster assembly (GO:0016226)	2.72121228
60	kynurenine metabolic process (GO:0070189)	2.69373758
61	adaptation of signaling pathway (GO:0023058)	2.67623461
62	response to gravity (GO:0009629)	2.66565889
63	positive regulation of prostaglandin secretion (GO:0032308)	2.64306049
64	cytidine metabolic process (GO:0046087)	2.64122920
65	cytidine catabolic process (GO:0006216)	2.64122920
66	cytidine deamination (GO:0009972)	2.64122920
67	spinal cord motor neuron differentiation (GO:0021522)	2.63521085
68	negative regulation of T cell differentiation in thymus (GO:0033085)	2.63000356
69	detection of mechanical stimulus involved in sensory perception of sound (GO:0050910)	2.61884966
70	intraciliary transport (GO:0042073)	2.61245690
71	Arp2/3 complex-mediated actin nucleation (GO:0034314)	2.61199704
72	chaperone-mediated protein transport (GO:0072321)	2.60496819
73	protein polyglutamylation (GO:0018095)	2.59466254
74	somite development (GO:0061053)	2.59242024
75	actin nucleation (GO:0045010)	2.59075427
76	exonucleolytic nuclear-transcribed mRNA catabolic process involved in deadenylation-dependent decay	2.57562270
77	regulation of dopamine uptake involved in synaptic transmission (GO:0051584)	2.55683938
78	regulation of catecholamine uptake involved in synaptic transmission (GO:0051940)	2.55683938
79	primary amino compound metabolic process (GO:1901160)	2.53973890
80	negative regulation of pathway-restricted SMAD protein phosphorylation (GO:0060394)	2.53687022
81	keratinocyte development (GO:0003334)	2.52837453
82	neuronal action potential (GO:0019228)	2.51270569
83	mitochondrial ATP synthesis coupled proton transport (GO:0042776)	2.51194114
84	mitochondrial electron transport, NADH to ubiquinone (GO:0006120)	2.50039435
85	DNA damage response, detection of DNA damage (GO:0042769)	2.49756212
86	protein-cofactor linkage (GO:0018065)	2.49569066
87	cullin deneddylation (GO:0010388)	2.48542777
88	positive regulation of protein homodimerization activity (GO:0090073)	2.48537741
89	positive regulation of mitochondrial fission (GO:0090141)	2.47462696
90	microtubule depolymerization (GO:0007019)	2.47388408
91	gamma-aminobutyric acid transport (GO:0015812)	2.46388568
92	estrogen biosynthetic process (GO:0006703)	2.46370819
93	regulation of microtubule-based movement (GO:0060632)	2.46325407
94	cardiac ventricle formation (GO:0003211)	2.45887230
95	seminiferous tubule development (GO:0072520)	2.45754020
96	cellular response to interleukin-15 (GO:0071350)	2.43188182
97	ribosomal small subunit assembly (GO:0000028)	2.43159666
98	mast cell activation (GO:0045576)	2.40771363
99	cell proliferation in forebrain (GO:0021846)	2.40504574
100	retina development in camera-type eye (GO:0060041)	2.40399438

Predicted upstream transcription factors (ChEA)

Rank	Gene Set	Z-score
1	E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse	4.31715425
2	EZH2_22144423_ChIP-Seq_EOC_Human	3.78053672
3	VDR_22108803_ChIP-Seq_LS180_Human	3.37785951
4	GABP_17652178_ChIP-ChIP_JURKAT_Human	3.12435792
5	ZNF274_21170338_ChIP-Seq_K562_Hela	3.07339806
6	IGF1R_20145208_ChIP-Seq_DFB_Human	2.63864664
7	TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse	2.58741690
8	EST1_17652178_ChIP-ChIP_JURKAT_Human	2.58583709
9	HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human	2.49910409
10	RUNX1_26923725_Chip-Seq_MACROPHAGESS_Mouse	2.45210022
11	GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse	2.37866461
12	FLI1_27457419_Chip-Seq_LIVER_Mouse	2.25087403
13	MYCN_21190229_ChIP-Seq_SHEP-21N_Human	2.24161950
14	KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human	2.18826939
15	GLI1_17442700_ChIP-ChIP_MESCs_Mouse	2.08100665
16	SOX9_22984422_ChIP-ChIP_TESTIS_Rat	2.06287415
17	MYC_18940864_ChIP-ChIP_HL60_Human	1.95191772
18	CTBP1_25329375_ChIP-Seq_LNCAP_Human	1.90839603
19	EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human	1.84388948
20	ZFP57_27257070_Chip-Seq_ESCs_Mouse	1.83063609
21	EWS_26573619_Chip-Seq_HEK293_Human	1.77938659
22	IRF1_19129219_ChIP-ChIP_H3396_Human	1.74230186
23	CTBP2_25329375_ChIP-Seq_LNCAP_Human	1.71982037
24	GBX2_23144817_ChIP-Seq_PC3_Human	1.67629149
25	P300_19829295_ChIP-Seq_ESCs_Human	1.61447339
26	TAF15_26573619_Chip-Seq_HEK293_Human	1.60813596
27	PCGF2_27294783_Chip-Seq_ESCs_Mouse	1.58685962
28	POU5F1_16153702_ChIP-ChIP_HESCs_Human	1.58204448
29	POU3F2_20337985_ChIP-ChIP_501MEL_Human	1.55917072
30	AR_20517297_ChIP-Seq_VCAP_Human	1.54681830
31	NR4A2_19515692_ChIP-ChIP_MN9D_Mouse	1.52307906
32	MYC_20876797_ChIP-ChIP_MEDULLOBLASTOMA_Human	1.50041261
33	VDR_23849224_ChIP-Seq_CD4+_Human	1.49648988
34	GRHL2_25758223_ChIP-Seq_PLACENTA_Mouse	1.48367517
35	JARID1A_20064375_ChIP-Seq_MESCs_Mouse	1.48275051
36	BMI1_23680149_ChIP-Seq_NPCS_Mouse	1.46733979
37	PCGF2_27294783_Chip-Seq_NPCs_Mouse	1.45796598
38	ER_23166858_ChIP-Seq_MCF-7_Human	1.45130130
39	NOTCH1_17114293_ChIP-ChIP_T-ALL_Human	1.42840304
40	TP53_22573176_ChIP-Seq_HFKS_Human	1.42218289
41	RNF2_27304074_Chip-Seq_NSC_Mouse	1.42064666
42	EED_16625203_ChIP-ChIP_MESCs_Mouse	1.40363694
43	CBX2_27304074_Chip-Seq_ESCs_Mouse	1.39926215
44	E2F4_17652178_ChIP-ChIP_JURKAT_Human	1.34884080
45	AUTS2_25519132_ChIP-Seq_293T-REX_Human	1.34867282
46	ELK1_19687146_ChIP-ChIP_HELA_Human	1.33797561
47	EZH2_27294783_Chip-Seq_NPCs_Mouse	1.30072007
48	EZH2_27304074_Chip-Seq_ESCs_Mouse	1.29192918
49	TDRD3_21172665_ChIP-Seq_MCF-7_Human	1.26439502
50	NFE2_27457419_Chip-Seq_LIVER_Mouse	1.25965690
51	IRF4_20064451_ChIP-Seq_CD4+T_Mouse	1.25612862
52	CBP_20019798_ChIP-Seq_JUKART_Human	1.25612862
53	SRF_21415370_ChIP-Seq_HL-1_Mouse	1.25177632
54	CEBPD_23245923_ChIP-Seq_MEFs_Mouse	1.23362675
55	ETS1_20019798_ChIP-Seq_JURKAT_Human	1.21923130
56	NOTCH1_21737748_ChIP-Seq_TLL_Human	1.21703252
57	CHD1_19587682_ChIP-ChIP_MESCs_Mouse	1.21580531
58	REST_21632747_ChIP-Seq_MESCs_Mouse	1.20264734
59	JARID2_20064375_ChIP-Seq_MESCs_Mouse	1.19507492
60	STAT6_20620947_ChIP-Seq_CD4_POS_T_Human	1.16973754
61	FOXA1_27270436_Chip-Seq_PROSTATE_Human	1.16625928
62	FOXA1_25329375_ChIP-Seq_VCAP_Human	1.16625928
63	ERA_21632823_ChIP-Seq_H3396_Human	1.15960524
64	SUZ12_27294783_Chip-Seq_NPCs_Mouse	1.15291732
65	UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human	1.14707506
66	PBX1_22567123_ChIP-ChIP_OVCAR3_Human	1.14075266
67	CEBPA_26348894_ChIP-Seq_LIVER_Mouse	1.11826479
68	FUS_26573619_Chip-Seq_HEK293_Human	1.11679590
69	IRF8_22096565_ChIP-ChIP_GC-B_Mouse	1.10848285
70	FOXP3_21729870_ChIP-Seq_TREG_Human	1.10313555
71	NR3C1_21868756_ChIP-Seq_MCF10A_Human	1.07665580
72	NCOR_22424771_ChIP-Seq_293T_Human	1.05822403
73	EBNA2_21746931_ChIP-Seq_IB4-LCL_Human	1.04973636
74	CDKN2AIP_20523734_ChIP-Seq_CORTICAL_Neurons	1.04693921
75	NANOG_20526341_ChIP-Seq_ESCs_Human	1.04616020
76	MEIS1_26253404_ChIP-Seq_OPTIC_CUPS_Mouse	1.03964429
77	EZH2_27294783_Chip-Seq_ESCs_Mouse	1.03847739
78	FOXH1_21741376_ChIP-Seq_EPCs_Human	1.03514290
79	HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse	1.02221322
80	GATA3_26560356_Chip-Seq_TH2_Human	1.02186674
81	HOXB7_26014856_ChIP-Seq_BT474_Human	1.02125924
82	NANOG_19829295_ChIP-Seq_ESCs_Human	1.01354670
83	SOX2_19829295_ChIP-Seq_ESCs_Human	1.01354670
84	PAX6_23342162_ChIP-ChIP_BETA-FORBRAIN-LENS_Mouse	1.01297728
85	LYL1_20887958_ChIP-Seq_HPC-7_Mouse	1.00983705
86	GATA3_21878914_ChIP-Seq_MCF-7_Human	1.00473398
87	KLF5_20875108_ChIP-Seq_MESCs_Mouse	1.00190774
88	SMAD4_21799915_ChIP-Seq_A2780_Human	0.99702852
89	CHD7_19251738_ChIP-ChIP_MESCs_Mouse	0.98313496
90	TOP2B_26459242_ChIP-Seq_MCF-7_Human	0.98208093
91	SUZ12_18692474_ChIP-Seq_MESCs_Mouse	0.97760111
92	SMAD2/3_21741376_ChIP-Seq_EPCs_Human	0.97641753
93	RUNX2_22187159_ChIP-Seq_PCA_Human	0.97378629
94	CIITA_18437201_ChIP-ChIP_Raji_B_and_iDC_Human	0.95646972
95	FOXP2_21765815_ChIP-ChIP_NEURO2A_Mouse	0.94289160
96	IRF8_22096565_ChIP-ChIP_GC-B_Human	0.93114517
97	FLI1_21867929_ChIP-Seq_TH2_Mouse	0.93024153
98	P53_22127205_ChIP-Seq_FIBROBLAST_Human	0.92827058
99	MYC_19829295_ChIP-Seq_ESCs_Human	0.92576013
100	STAT3_23295773_ChIP-Seq_U87_Human	0.86818504

Predicted mouse phenotypes (MGI)

Rank	Gene Set	Z-score
1	MP0006292_abnormal_olfactory_placode	5.72464627
2	MP0002638_abnormal_pupillary_reflex	4.25195423
3	MP0003787_abnormal_imprinting	3.96155731
4	MP0008877_abnormal_DNA_methylation	3.87928046
5	MP0008789_abnormal_olfactory_epithelium	3.55177491
6	MP0005257_abnormal_intraocular_pressure	3.10334048
7	MP0005671_abnormal_response_to	2.74022710
8	MP0005394_taste/olfaction_phenotype	2.63510856
9	MP0005499_abnormal_olfactory_system	2.63510856
10	MP0004885_abnormal_endolymph	2.47842411
11	MP0004147_increased_porphyrin_level	2.28358722
12	MP0006276_abnormal_autonomic_nervous	2.27948874
13	MP0002102_abnormal_ear_morphology	2.19883424
14	MP0002938_white_spotting	2.13976156
15	MP0005084_abnormal_gallbladder_morpholo	2.05435784
16	MP0001968_abnormal_touch/_nociception	2.03831449
17	MP0003121_genomic_imprinting	2.03105747
18	MP0006072_abnormal_retinal_apoptosis	1.87095858
19	MP0005551_abnormal_eye_electrophysiolog	1.86459617
20	MP0003880_abnormal_central_pattern	1.82204175
21	MP0002736_abnormal_nociception_after	1.73573638
22	MP0001986_abnormal_taste_sensitivity	1.63743566
23	MP0002272_abnormal_nervous_system	1.63255092
24	MP0001919_abnormal_reproductive_system	1.55865317
25	MP0001905_abnormal_dopamine_level	1.55095276
26	MP0009745_abnormal_behavioral_response	1.49013234
27	MP0002160_abnormal_reproductive_system	1.48788769
28	MP0001501_abnormal_sleep_pattern	1.46633682
29	MP0005389_reproductive_system_phenotype	1.44309195
30	MP0002138_abnormal_hepatobiliary_system	1.43000924
31	MP0003011_delayed_dark_adaptation	1.36979916
32	MP0009046_muscle_twitch	1.35226601
33	MP0005423_abnormal_somatic_nervous	1.34617832
34	MP0002876_abnormal_thyroid_physiology	1.30735611
35	MP0008872_abnormal_physiological_respon	1.30145541
36	MP0002234_abnormal_pharynx_morphology	1.28979282
37	MP0002572_abnormal_emotion/affect_behav	1.21635947
38	MP0003866_abnormal_defecation	1.19415991
39	MP0002837_dystrophic_cardiac_calcinosis	1.16803983
40	MP0000613_abnormal_salivary_gland	1.16717445
41	MP0005410_abnormal_fertilization	1.12300731
42	MP0008875_abnormal_xenobiotic_pharmacok	1.11637829
43	MP0004742_abnormal_vestibular_system	1.10719297
44	MP0004133_heterotaxia	1.09804221
45	MP0008775_abnormal_heart_ventricle	1.09439774
46	MP0002557_abnormal_social/conspecific_i	1.06824047
47	MP0005253_abnormal_eye_physiology	1.04536962
48	MP0001485_abnormal_pinna_reflex	1.00928645
49	MP0005645_abnormal_hypothalamus_physiol	1.00552355
50	MP0003119_abnormal_digestive_system	0.99442414
51	MP0000778_abnormal_nervous_system	0.99312947
52	MP0002733_abnormal_thermal_nociception	0.97402896
53	MP0002735_abnormal_chemical_nociception	0.95569175
54	MP0003646_muscle_fatigue	0.95318939
55	MP0005377_hearing/vestibular/ear_phenot	0.93511441
56	MP0003878_abnormal_ear_physiology	0.93511441
57	MP0004142_abnormal_muscle_tone	0.92320806
58	MP0005167_abnormal_blood-brain_barrier	0.92109904
59	MP0001970_abnormal_pain_threshold	0.91500021
60	MP0003724_increased_susceptibility_to	0.91343993
61	MP0000049_abnormal_middle_ear	0.86932357
62	MP0005195_abnormal_posterior_eye	0.86699089
63	MP0003315_abnormal_perineum_morphology	0.86121880
64	MP0003786_premature_aging	0.84002278
65	MP0002653_abnormal_ependyma_morphology	0.83156631
66	MP0002752_abnormal_somatic_nervous	0.81748956
67	MP0002163_abnormal_gland_morphology	0.80839765
68	MP0008058_abnormal_DNA_repair	0.80538343
69	MP0001486_abnormal_startle_reflex	0.79821941
70	MP0004924_abnormal_behavior	0.79679216
71	MP0005386_behavior/neurological_phenoty	0.79679216
72	MP0003635_abnormal_synaptic_transmissio	0.77280401
73	MP0000955_abnormal_spinal_cord	0.75436819
74	MP0003283_abnormal_digestive_organ	0.74845523
75	MP0005083_abnormal_biliary_tract	0.74582040
76	MP0002067_abnormal_sensory_capabilities	0.72108568
77	MP0002277_abnormal_respiratory_mucosa	0.71946513
78	MP0000631_abnormal_neuroendocrine_gland	0.71945259
79	MP0000230_abnormal_systemic_arterial	0.71718219
80	MP0004859_abnormal_synaptic_plasticity	0.70522877
81	MP0005187_abnormal_penis_morphology	0.69983529
82	MP0002751_abnormal_autonomic_nervous	0.69643489
83	MP0009764_decreased_sensitivity_to	0.69384852
84	MP0002063_abnormal_learning/memory/cond	0.67695711
85	MP0003252_abnormal_bile_duct	0.67487251
86	MP0001440_abnormal_grooming_behavior	0.66855007
87	MP0001873_stomach_inflammation	0.66503771
88	MP0001293_anophthalmia	0.66351640
89	MP0002064_seizures	0.66316509
90	MP0002148_abnormal_hypersensitivity_rea	0.64342469
91	MP0010386_abnormal_urinary_bladder	0.64278030
92	MP0003122_maternal_imprinting	0.64116348
93	MP0001800_abnormal_humoral_immune	0.63383927
94	MP0001529_abnormal_vocalization	0.62849744
95	MP0001119_abnormal_female_reproductive	0.62672402
96	MP0000685_abnormal_immune_system	0.61953788
97	MP0003718_maternal_effect	0.60676829
98	MP0010094_abnormal_chromosome_stability	0.59808327
99	MP0002693_abnormal_pancreas_physiology	0.59631243
100	MP0000427_abnormal_hair_cycle	0.59629072

Predicted human phenotypes

Rank	Gene Set	Z-score
1	Hypoplasia of the fovea (HP:0007750)	4.34121601
2	Aplasia/Hypoplasia of the fovea (HP:0008060)	4.34121601
3	Abnormality of the fovea (HP:0000493)	3.67842322
4	Abnormality of midbrain morphology (HP:0002418)	3.52454508
5	Molar tooth sign on MRI (HP:0002419)	3.52454508
6	Pancreatic fibrosis (HP:0100732)	3.28263435
7	Pancreatic cysts (HP:0001737)	3.18593376
8	Retinal dysplasia (HP:0007973)	3.13761808
9	Absent rod-and cone-mediated responses on ERG (HP:0007688)	3.11028187
10	Pendular nystagmus (HP:0012043)	3.02049016
11	True hermaphroditism (HP:0010459)	3.01909586
12	Abolished electroretinogram (ERG) (HP:0000550)	3.00213028
13	Renal cortical cysts (HP:0000803)	2.97689743
14	Abnormality of the renal cortex (HP:0011035)	2.96120564
15	Severe combined immunodeficiency (HP:0004430)	2.90109834
16	Hyperventilation (HP:0002883)	2.87270074
17	IgG deficiency (HP:0004315)	2.78151242
18	Medial flaring of the eyebrow (HP:0010747)	2.72372692
19	Congenital stationary night blindness (HP:0007642)	2.66048822
20	Abnormality of the ileum (HP:0001549)	2.62979798
21	Type II lissencephaly (HP:0007260)	2.62781438
22	Aplasia/Hypoplasia of the uvula (HP:0010293)	2.59335670
23	Limb dystonia (HP:0002451)	2.56427253
24	Nephronophthisis (HP:0000090)	2.56115169
25	Meckel diverticulum (HP:0002245)	2.51560981
26	Reticulocytopenia (HP:0001896)	2.49339734
27	Aplasia/Hypoplasia of the macula (HP:0008059)	2.46960019
28	Abnormal respiratory epithelium morphology (HP:0012253)	2.44823862
29	Abnormal respiratory motile cilium morphology (HP:0005938)	2.44823862
30	Optic nerve hypoplasia (HP:0000609)	2.44539088
31	Lissencephaly (HP:0001339)	2.43119849
32	Aplasia/Hypoplasia of the optic nerve (HP:0008058)	2.40424031
33	Optic nerve coloboma (HP:0000588)	2.39900101
34	Gait imbalance (HP:0002141)	2.37754554
35	Acute necrotizing encephalopathy (HP:0006965)	2.37466998
36	Abnormality of DNA repair (HP:0003254)	2.34950372
37	Aplasia/Hypoplasia affecting the retina (HP:0008061)	2.31790300
38	Abnormal rod and cone electroretinograms (HP:0008323)	2.30276935
39	Decreased central vision (HP:0007663)	2.30096017
40	Mitochondrial inheritance (HP:0001427)	2.29223875
41	Hyperglycinemia (HP:0002154)	2.26857598
42	Thyroiditis (HP:0100646)	2.26385552
43	Absent thumb (HP:0009777)	2.24943393
44	Methylmalonic acidemia (HP:0002912)	2.19420843
45	Abnormality of the renal medulla (HP:0100957)	2.17614365
46	Combined immunodeficiency (HP:0005387)	2.15773322
47	Broad-based gait (HP:0002136)	2.15223493
48	Abnormality of the renal collecting system (HP:0004742)	2.14088252
49	Pachygyria (HP:0001302)	2.13563492
50	Keratoconus (HP:0000563)	2.12026842
51	Increased corneal curvature (HP:0100692)	2.12026842
52	Neoplasm of head and neck (HP:0012288)	2.11637893
53	Esophageal neoplasm (HP:0100751)	2.11637893
54	Congenital primary aphakia (HP:0007707)	2.10297065
55	Acute encephalopathy (HP:0006846)	2.09640743
56	Stenosis of the external auditory canal (HP:0000402)	2.08149970
57	Clubbing of toes (HP:0100760)	2.07888020
58	Abnormal mitochondria in muscle tissue (HP:0008316)	2.07497223
59	Pancytopenia (HP:0001876)	2.04916693
60	Abnormality of the preputium (HP:0100587)	2.04043769
61	Attenuation of retinal blood vessels (HP:0007843)	2.03331064
62	Duplicated collecting system (HP:0000081)	2.02480817
63	Nephrogenic diabetes insipidus (HP:0009806)	2.02436207
64	Dyskinesia (HP:0100660)	1.99748205
65	Prostate neoplasm (HP:0100787)	1.99219946
66	Decreased electroretinogram (ERG) amplitude (HP:0000654)	1.97763412
67	Congenital, generalized hypertrichosis (HP:0004540)	1.97606429
68	Aplasia/Hypoplasia of the lens (HP:0008063)	1.96858073
69	Abnormality of alanine metabolism (HP:0010916)	1.96244748
70	Hyperalaninemia (HP:0003348)	1.96244748
71	Abnormality of pyruvate family amino acid metabolism (HP:0010915)	1.96244748
72	Stomach cancer (HP:0012126)	1.94722545
73	Keratitis (HP:0000491)	1.93927991
74	Progressive microcephaly (HP:0000253)	1.93922105
75	Increased CSF lactate (HP:0002490)	1.93310574
76	Aplasia/Hypoplasia of the tibia (HP:0005772)	1.93308440
77	Congenital hepatic fibrosis (HP:0002612)	1.90404671
78	Atonic seizures (HP:0010819)	1.89639299
79	Abnormality of chromosome stability (HP:0003220)	1.88378791
80	Lipid accumulation in hepatocytes (HP:0006561)	1.85799428
81	Abnormality of B cell number (HP:0010975)	1.85188050
82	Inability to walk (HP:0002540)	1.84752224
83	Progressive macrocephaly (HP:0004481)	1.83492735
84	Small intestinal stenosis (HP:0012848)	1.83272150
85	Duodenal stenosis (HP:0100867)	1.83272150
86	Horseshoe kidney (HP:0000085)	1.82827643
87	Chorioretinal atrophy (HP:0000533)	1.82783564
88	Abnormality of glycine metabolism (HP:0010895)	1.82143446
89	Abnormality of serine family amino acid metabolism (HP:0010894)	1.82143446
90	Abnormality of eosinophils (HP:0001879)	1.81970177
91	Chromosomal breakage induced by crosslinking agents (HP:0003221)	1.79484791
92	Increased hepatocellular lipid droplets (HP:0006565)	1.79416310
93	Chromsome breakage (HP:0040012)	1.79248851
94	Abnormality of the labia minora (HP:0012880)	1.78230029
95	Abnormality of the prostate (HP:0008775)	1.77888490
96	Aplasia/Hypoplasia of the brainstem (HP:0007362)	1.77224822
97	Hypoplasia of the brainstem (HP:0002365)	1.77224822
98	Abnormality of the carotid arteries (HP:0005344)	1.75983092
99	Sclerocornea (HP:0000647)	1.74992423
100	Methylmalonic aciduria (HP:0012120)	1.73992837

Predicted kinase interactions (KEA)

Rank	Gene Set	Z-score
1	MAP4K2	3.98195169
2	TLK1	3.62562453
3	MAPK13	3.50312479
4	TIE1	3.30516342
5	STK16	3.13991187
6	ZAK	3.07329075
7	GRK1	2.54783470
8	BCKDK	2.52342178
9	BMPR1B	2.48405368
10	FRK	2.47670570
11	PTK2B	2.45747984
12	KDR	2.25580053
13	VRK2	1.90187607
14	CASK	1.85684249
15	MARK1	1.85566951
16	CDK19	1.83330411
17	TXK	1.77385236
18	INSRR	1.77160417
19	WNK3	1.60090109
20	TAOK3	1.57281325
21	CAMKK2	1.56678206
22	TESK2	1.48881458
23	NUAK1	1.48838467
24	MAP2K2	1.43391792
25	LIMK1	1.42474765
26	ADRBK2	1.40729043
27	VRK1	1.28921229
28	DAPK2	1.21119321
29	PHKG1	1.15629296
30	PHKG2	1.15629296
31	IKBKE	1.12993490
32	TRIM28	1.12763617
33	MAP2K7	1.10893954
34	BUB1	1.10123556
35	MATK	1.09824343
36	DYRK2	1.09387058
37	IKBKB	1.09382442
38	CSNK1G3	1.09303846
39	BCR	0.98880679
40	SRPK1	0.97254301
41	TEC	0.97121579
42	PINK1	0.94743473
43	WEE1	0.91265858
44	EIF2AK2	0.89081316
45	CSNK1G2	0.88909404
46	HIPK2	0.87144402
47	CSNK1G1	0.86548534
48	WNK4	0.84584430
49	PRKCQ	0.83827185
50	ARAF	0.83568055
51	MAPK7	0.79590751
52	OXSR1	0.79334004
53	ACVR1B	0.78574822
54	CSNK1A1L	0.76253090
55	MAP3K4	0.71885417
56	GRK6	0.71596365
57	RPS6KA5	0.71530136
58	MINK1	0.69519648
59	PLK4	0.69134088
60	MAPKAPK3	0.67724829
61	PRKCG	0.65591660
62	FES	0.63946512
63	ITK	0.61924952
64	EPHA4	0.58731477
65	SYK	0.54662584
66	MAP3K9	0.53574581
67	PKN1	0.52177285
68	RPS6KA2	0.51495062
69	MAP2K1	0.50055455
70	NEK1	0.49603323
71	TGFBR1	0.49482050
72	EPHB2	0.49133398
73	TBK1	0.48617631
74	ADRBK1	0.46337536
75	RPS6KB2	0.45683738
76	CCNB1	0.44855657
77	DAPK1	0.44104629
78	CAMKK1	0.39782782
79	RPS6KA6	0.39405203
80	PRKACA	0.37300204
81	PASK	0.36782139
82	CSNK1D	0.35554839
83	RIPK4	0.34643305
84	PAK6	0.34554585
85	MAP3K11	0.34231080
86	TAOK2	0.32563967
87	LYN	0.31693778
88	MAP3K14	0.31250302
89	KIT	0.30929467
90	ERBB4	0.29845861
91	LCK	0.29629686
92	MAPKAPK5	0.28420358
93	PRKCD	0.27865906
94	CSNK1A1	0.27310282
95	MST4	0.25830618
96	PRKCE	0.25829346
97	MAP4K1	0.25719264
98	GRK7	0.24535193
99	PRKCA	0.24024557
100	AURKA	0.23912751

Predicted pathways (KEGG)

Rank	Gene Set	Z-score
1	Oxidative phosphorylation_Homo sapiens_hsa00190	3.39924816
2	Parkinsons disease_Homo sapiens_hsa05012	2.76167047
3	Primary immunodeficiency_Homo sapiens_hsa05340	2.59573004
4	Fanconi anemia pathway_Homo sapiens_hsa03460	2.48519201
5	RNA polymerase_Homo sapiens_hsa03020	2.47783845
6	Maturity onset diabetes of the young_Homo sapiens_hsa04950	2.37249388
7	Homologous recombination_Homo sapiens_hsa03440	2.22504679
8	Phototransduction_Homo sapiens_hsa04744	2.22074240
9	Ribosome_Homo sapiens_hsa03010	2.04248923
10	Proteasome_Homo sapiens_hsa03050	2.02539227
11	Cytosolic DNA-sensing pathway_Homo sapiens_hsa04623	1.83154211
12	Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa00563	1.82431299
13	Mismatch repair_Homo sapiens_hsa03430	1.82069005
14	Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa00604	1.79074149
15	Nicotine addiction_Homo sapiens_hsa05033	1.76678266
16	Neuroactive ligand-receptor interaction_Homo sapiens_hsa04080	1.73332928
17	Linoleic acid metabolism_Homo sapiens_hsa00591	1.70770070
18	Huntingtons disease_Homo sapiens_hsa05016	1.69786631
19	Cardiac muscle contraction_Homo sapiens_hsa04260	1.69296588
20	Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa00130	1.67151531
21	DNA replication_Homo sapiens_hsa03030	1.64987461
22	Nitrogen metabolism_Homo sapiens_hsa00910	1.59202239
23	Primary bile acid biosynthesis_Homo sapiens_hsa00120	1.57536834
24	Alzheimers disease_Homo sapiens_hsa05010	1.57146063
25	Protein export_Homo sapiens_hsa03060	1.55087820
26	alpha-Linolenic acid metabolism_Homo sapiens_hsa00592	1.54038288
27	Synthesis and degradation of ketone bodies_Homo sapiens_hsa00072	1.53056567
28	Pyrimidine metabolism_Homo sapiens_hsa00240	1.45789119
29	Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa00601	1.43135184
30	Tryptophan metabolism_Homo sapiens_hsa00380	1.42009449
31	Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa04932	1.41980602
32	Propanoate metabolism_Homo sapiens_hsa00640	1.32902869
33	Intestinal immune network for IgA production_Homo sapiens_hsa04672	1.28788480
34	Base excision repair_Homo sapiens_hsa03410	1.25904843
35	Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa00603	1.25403880
36	RNA degradation_Homo sapiens_hsa03018	1.25305839
37	Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa00534	1.22361010
38	Taurine and hypotaurine metabolism_Homo sapiens_hsa00430	1.17359372
39	Steroid hormone biosynthesis_Homo sapiens_hsa00140	1.15721931
40	Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa00533	1.13333835
41	Butanoate metabolism_Homo sapiens_hsa00650	1.11103409
42	Purine metabolism_Homo sapiens_hsa00230	1.07446307
43	Taste transduction_Homo sapiens_hsa04742	1.07095867
44	Valine, leucine and isoleucine degradation_Homo sapiens_hsa00280	1.05729123
45	Olfactory transduction_Homo sapiens_hsa04740	1.02198010
46	Morphine addiction_Homo sapiens_hsa05032	1.01704132
47	Ascorbate and aldarate metabolism_Homo sapiens_hsa00053	0.98461750
48	Nucleotide excision repair_Homo sapiens_hsa03420	0.97997065
49	Basal transcription factors_Homo sapiens_hsa03022	0.97596245
50	Caffeine metabolism_Homo sapiens_hsa00232	0.95358705
51	Pyruvate metabolism_Homo sapiens_hsa00620	0.90455674
52	Hematopoietic cell lineage_Homo sapiens_hsa04640	0.90188846
53	Cytokine-cytokine receptor interaction_Homo sapiens_hsa04060	0.88464121
54	Arachidonic acid metabolism_Homo sapiens_hsa00590	0.86625928
55	Peroxisome_Homo sapiens_hsa04146	0.83539713
56	Graft-versus-host disease_Homo sapiens_hsa05332	0.81718284
57	Rheumatoid arthritis_Homo sapiens_hsa05323	0.80669381
58	Retinol metabolism_Homo sapiens_hsa00830	0.80301280
59	Fatty acid elongation_Homo sapiens_hsa00062	0.78288904
60	Histidine metabolism_Homo sapiens_hsa00340	0.77254024
61	Chemical carcinogenesis_Homo sapiens_hsa05204	0.76633039
62	Autoimmune thyroid disease_Homo sapiens_hsa05320	0.74933298
63	RIG-I-like receptor signaling pathway_Homo sapiens_hsa04622	0.74646616
64	Non-homologous end-joining_Homo sapiens_hsa03450	0.73423924
65	Allograft rejection_Homo sapiens_hsa05330	0.71647906
66	Salivary secretion_Homo sapiens_hsa04970	0.70748776
67	Cell adhesion molecules (CAMs)_Homo sapiens_hsa04514	0.70310193
68	T cell receptor signaling pathway_Homo sapiens_hsa04660	0.68382238
69	Circadian entrainment_Homo sapiens_hsa04713	0.67736814
70	Steroid biosynthesis_Homo sapiens_hsa00100	0.67633815
71	Asthma_Homo sapiens_hsa05310	0.66625013
72	Ovarian steroidogenesis_Homo sapiens_hsa04913	0.66523723
73	Fat digestion and absorption_Homo sapiens_hsa04975	0.65394279
74	Drug metabolism - cytochrome P450_Homo sapiens_hsa00982	0.63865054
75	Metabolic pathways_Homo sapiens_hsa01100	0.61474994
76	Systemic lupus erythematosus_Homo sapiens_hsa05322	0.61380045
77	Porphyrin and chlorophyll metabolism_Homo sapiens_hsa00860	0.61293312
78	Pentose and glucuronate interconversions_Homo sapiens_hsa00040	0.61098410
79	NF-kappa B signaling pathway_Homo sapiens_hsa04064	0.59178970
80	beta-Alanine metabolism_Homo sapiens_hsa00410	0.58804583
81	Serotonergic synapse_Homo sapiens_hsa04726	0.58438113
82	Sulfur relay system_Homo sapiens_hsa04122	0.57463061
83	Spliceosome_Homo sapiens_hsa03040	0.57011457
84	Dopaminergic synapse_Homo sapiens_hsa04728	0.56904209
85	Terpenoid backbone biosynthesis_Homo sapiens_hsa00900	0.56382634
86	Glycerolipid metabolism_Homo sapiens_hsa00561	0.56252344
87	Collecting duct acid secretion_Homo sapiens_hsa04966	0.49353276
88	GABAergic synapse_Homo sapiens_hsa04727	0.46620440
89	Ether lipid metabolism_Homo sapiens_hsa00565	0.45755935
90	Natural killer cell mediated cytotoxicity_Homo sapiens_hsa04650	0.44392991
91	Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa00980	0.44280860
92	p53 signaling pathway_Homo sapiens_hsa04115	0.43900047
93	Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa01040	0.43416616
94	Selenocompound metabolism_Homo sapiens_hsa00450	0.43135175
95	Folate biosynthesis_Homo sapiens_hsa00790	0.42440990
96	Cysteine and methionine metabolism_Homo sapiens_hsa00270	0.42326479
97	Regulation of autophagy_Homo sapiens_hsa04140	0.39669262
98	Arginine and proline metabolism_Homo sapiens_hsa00330	0.38816975
99	Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa00970	0.38609339
100	One carbon pool by folate_Homo sapiens_hsa00670	0.38317276

HNRNPKP3

Functional Annotation Prediction

Predicted biological processes (GO)

Predicted upstream transcription factors (ChEA)

Predicted mouse phenotypes (MGI)

Predicted human phenotypes

Predicted kinase interactions (KEA)

Predicted pathways (KEGG)

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