HNRNPKP4

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: No gene information available for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1regulation of single stranded viral RNA replication via double stranded DNA intermediate (GO:00450917.65952597
2DNA deamination (GO:0045006)7.61559415
3cytidine deamination (GO:0009972)7.06921233
4cytidine metabolic process (GO:0046087)7.06921233
5cytidine catabolic process (GO:0006216)7.06921233
6pyrimidine ribonucleoside catabolic process (GO:0046133)6.09520178
7sequestering of actin monomers (GO:0042989)5.29987613
8cellular response to interleukin-15 (GO:0071350)4.83166662
9positive regulation of defense response to virus by host (GO:0002230)4.34209243
10Arp2/3 complex-mediated actin nucleation (GO:0034314)4.32635882
11response to pheromone (GO:0019236)4.13950880
12negative T cell selection (GO:0043383)3.99667262
13regulation of activation of Janus kinase activity (GO:0010533)3.93572040
14actin nucleation (GO:0045010)3.88187197
15positive regulation of T cell mediated cytotoxicity (GO:0001916)3.84293512
16platelet dense granule organization (GO:0060155)3.73025668
17negative regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051436)3.66311149
18DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest (GO:003.60300542
19water-soluble vitamin biosynthetic process (GO:0042364)3.57915100
20response to interleukin-15 (GO:0070672)3.57075615
21DNA demethylation (GO:0080111)3.54490042
22regulation of cellular amino acid metabolic process (GO:0006521)3.52179031
23positive regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051437)3.49654493
24signal transduction involved in mitotic DNA damage checkpoint (GO:1902402)3.48960007
25signal transduction involved in mitotic cell cycle checkpoint (GO:0072413)3.48960007
26signal transduction involved in mitotic DNA integrity checkpoint (GO:1902403)3.48960007
27intracellular signal transduction involved in G1 DNA damage checkpoint (GO:1902400)3.48938052
28signal transduction involved in mitotic G1 DNA damage checkpoint (GO:0072431)3.48938052
29positive regulation of leukocyte mediated cytotoxicity (GO:0001912)3.47862634
30proteasome assembly (GO:0043248)3.41733407
31regulation of T cell mediated cytotoxicity (GO:0001914)3.38761228
32positive T cell selection (GO:0043368)3.38463711
33interferon-gamma production (GO:0032609)3.35676642
34signal transduction involved in cell cycle checkpoint (GO:0072395)3.32869231
35regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051439)3.31769491
36negative regulation of ligase activity (GO:0051352)3.31448267
37negative regulation of ubiquitin-protein transferase activity (GO:0051444)3.31448267
38signal transduction involved in DNA integrity checkpoint (GO:0072401)3.31226753
39signal transduction involved in DNA damage checkpoint (GO:0072422)3.31226753
40protein neddylation (GO:0045116)3.31002297
41regulation of leukocyte mediated cytotoxicity (GO:0001910)3.26149603
42cell wall macromolecule catabolic process (GO:0016998)3.21118328
43energy coupled proton transport, down electrochemical gradient (GO:0015985)3.18937801
44ATP synthesis coupled proton transport (GO:0015986)3.18937801
45regulation of gamma-delta T cell differentiation (GO:0045586)3.18758050
46cell wall macromolecule metabolic process (GO:0044036)3.16906462
47positive regulation of alpha-beta T cell proliferation (GO:0046641)3.13913296
48antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-dependent (GO:3.12427224
49anaphase-promoting complex-dependent proteasomal ubiquitin-dependent protein catabolic process (GO:03.10745036
50cellular defense response (GO:0006968)3.09710615
51regulation of double-strand break repair via homologous recombination (GO:0010569)3.09627363
52RNA splicing, via endonucleolytic cleavage and ligation (GO:0000394)3.09115056
53tRNA splicing, via endonucleolytic cleavage and ligation (GO:0006388)3.09115056
54positive regulation of cell killing (GO:0031343)3.07923619
55mitochondrial ATP synthesis coupled proton transport (GO:0042776)3.05330116
56regulation of memory T cell differentiation (GO:0043380)3.04810247
57regulation of regulatory T cell differentiation (GO:0045589)3.03883828
58positive regulation of natural killer cell mediated immunity (GO:0002717)3.02733112
59protein deneddylation (GO:0000338)3.02659497
60pyrimidine nucleoside catabolic process (GO:0046135)3.02279124
61antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-independent (G2.99308522
62positive regulation of ubiquitin-protein transferase activity (GO:0051443)2.93728689
63positive regulation of T-helper 1 type immune response (GO:0002827)2.93090438
64antigen processing and presentation of exogenous peptide antigen via MHC class I (GO:0042590)2.92690829
65regulation of cell killing (GO:0031341)2.92335440
66positive regulation of natural killer cell mediated cytotoxicity (GO:0045954)2.90386177
67regulation of defense response to virus by host (GO:0050691)2.86972717
68regulation of natural killer cell mediated immunity (GO:0002715)2.84937804
69regulation of natural killer cell mediated cytotoxicity (GO:0042269)2.84937804
70mitochondrial electron transport, NADH to ubiquinone (GO:0006120)2.84382574
71negative thymic T cell selection (GO:0045060)2.82850256
72positive regulation of ligase activity (GO:0051351)2.82526491
73positive regulation of T cell mediated immunity (GO:0002711)2.80626172
74negative regulation of mast cell activation (GO:0033004)2.78142909
75DNA dealkylation (GO:0035510)2.74739680
76cullin deneddylation (GO:0010388)2.72944694
77positive regulation of gamma-delta T cell activation (GO:0046645)2.71094082
78negative regulation of transcription elongation from RNA polymerase II promoter (GO:0034244)2.70901572
79positive regulation of antigen receptor-mediated signaling pathway (GO:0050857)2.69791088
80positive regulation of cell cycle arrest (GO:0071158)2.69647495
81microtubule depolymerization (GO:0007019)2.69200865
82DNA damage response, signal transduction by p53 class mediator (GO:0030330)2.66999245
83T cell migration (GO:0072678)2.66897260
84ubiquinone metabolic process (GO:0006743)2.64045464
85negative regulation by host of viral transcription (GO:0043922)2.63621568
86regulation of T cell receptor signaling pathway (GO:0050856)2.62038002
87protein complex biogenesis (GO:0070271)2.60887275
88dopamine transport (GO:0015872)2.60325139
89positive thymic T cell selection (GO:0045059)2.59947506
90regulation of cellular amine metabolic process (GO:0033238)2.59035700
91negative regulation of viral genome replication (GO:0045071)2.58261510
92S-adenosylmethionine metabolic process (GO:0046500)2.56510088
93peptidyl-arginine omega-N-methylation (GO:0035247)2.56123830
94pyrimidine deoxyribonucleotide catabolic process (GO:0009223)2.55326255
95metallo-sulfur cluster assembly (GO:0031163)2.54524558
96iron-sulfur cluster assembly (GO:0016226)2.54524558
97T cell receptor signaling pathway (GO:0050852)2.54193523
98ubiquinone biosynthetic process (GO:0006744)2.52774050
99antigen processing and presentation of peptide antigen via MHC class I (GO:0002474)2.52669943
100positive regulation of tyrosine phosphorylation of Stat5 protein (GO:0042523)2.52453033

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse4.47084469
2KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human4.34524288
3BP1_19119308_ChIP-ChIP_Hs578T_Human4.15256479
4NOTCH1_17114293_ChIP-ChIP_T-ALL_Human3.67292832
5GABP_17652178_ChIP-ChIP_JURKAT_Human3.58587681
6EST1_17652178_ChIP-ChIP_JURKAT_Human3.11725229
7JARID1A_20064375_ChIP-Seq_MESCs_Mouse2.83954364
8SOX9_22984422_ChIP-ChIP_TESTIS_Rat2.76947638
9ELF1_17652178_ChIP-ChIP_JURKAT_Human2.74398087
10HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human2.64981723
11VDR_23849224_ChIP-Seq_CD4+_Human2.59629658
12IRF1_21803131_ChIP-Seq_MONOCYTES_Human2.58160162
13IGF1R_20145208_ChIP-Seq_DFB_Human2.46487939
14CHD1_19587682_ChIP-ChIP_MESCs_Mouse2.44611506
15STAT6_20620947_ChIP-Seq_CD4_POS_T_Human2.39808004
16IRF8_22096565_ChIP-ChIP_GC-B_Mouse2.39177692
17SRF_21415370_ChIP-Seq_HL-1_Mouse2.28414488
18ZNF274_21170338_ChIP-Seq_K562_Hela2.26735143
19ETS1_20019798_ChIP-Seq_JURKAT_Human2.19963811
20VDR_22108803_ChIP-Seq_LS180_Human2.18373992
21CREB1_15753290_ChIP-ChIP_HEK293T_Human2.12271700
22NOTCH1_21737748_ChIP-Seq_TLL_Human2.07146749
23CIITA_25753668_ChIP-Seq_RAJI_Human2.06052303
24ELK1_19687146_ChIP-ChIP_HELA_Human2.00056068
25FOXP3_21729870_ChIP-Seq_TREG_Human1.97543681
26MYCN_21190229_ChIP-Seq_SHEP-21N_Human1.92659254
27HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse1.91347185
28E2F4_17652178_ChIP-ChIP_JURKAT_Human1.88193404
29FLI1_27457419_Chip-Seq_LIVER_Mouse1.84463063
30MYB_26560356_Chip-Seq_TH2_Human1.76074150
31PDX1_19855005_ChIP-ChIP_MIN6_Mouse1.73629470
32HOXB4_20404135_ChIP-ChIP_EML_Mouse1.72734337
33IRF8_22096565_ChIP-ChIP_GC-B_Human1.72133172
34MYBL1_21750041_ChIP-ChIP_SPERMATOCYTES_Mouse1.63848050
35YY1_21170310_ChIP-Seq_MESCs_Mouse1.62812980
36FOXP3_17237761_ChIP-ChIP_TREG_Mouse1.61465236
37LYL1_20887958_ChIP-Seq_HPC-7_Mouse1.61129172
38CEBPB_23403033_ChIP-Seq_LIVER_Mouse1.59338948
39GATA3_26560356_Chip-Seq_TH2_Human1.58924557
40MYC_18940864_ChIP-ChIP_HL60_Human1.54517091
41IRF8_21731497_ChIP-ChIP_J774_Mouse1.51432011
42SPI1_22096565_ChIP-ChIP_GC-B_Mouse1.49530102
43FLI1_20887958_ChIP-Seq_HPC-7_Mouse1.48584175
44PAX6_23342162_ChIP-ChIP_BETA-FORBRAIN-LENS_Mouse1.47694601
45STAT4_19710469_ChIP-ChIP_TH1__Mouse1.45142924
46EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human1.43041122
47TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.41592446
48GATA3_27048872_Chip-Seq_THYMUS_Human1.39287001
49DCP1A_22483619_ChIP-Seq_HELA_Human1.38453360
50EWS_26573619_Chip-Seq_HEK293_Human1.37535135
51RUNX1_20887958_ChIP-Seq_HPC-7_Mouse1.32966282
52PADI4_21655091_ChIP-ChIP_MCF-7_Human1.29133984
53FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse1.28999722
54GABP_19822575_ChIP-Seq_HepG2_Human1.27557848
55IRF1_19129219_ChIP-ChIP_H3396_Human1.26798073
56PCGF2_27294783_Chip-Seq_ESCs_Mouse1.26284413
57AR_20517297_ChIP-Seq_VCAP_Human1.25439515
58STAT6_21828071_ChIP-Seq_BEAS2B_Human1.24924312
59SPI1_22790984_ChIP-Seq_ERYTHROLEUKEMIA_Mouse1.21453620
60POU3F2_20337985_ChIP-ChIP_501MEL_Human1.19457683
61RUNX_20019798_ChIP-Seq_JUKART_Human1.18520928
62TP53_22573176_ChIP-Seq_HFKS_Human1.18426373
63HTT_18923047_ChIP-ChIP_STHdh_Human1.16612103
64MYC_18358816_ChIP-ChIP_MESCs_Mouse1.16499731
65TAL1_20887958_ChIP-Seq_HPC-7_Mouse1.15880301
66ZFP42_18358816_ChIP-ChIP_MESCs_Mouse1.14985362
67POU5F1_18358816_ChIP-ChIP_MESCs_Mouse1.13617492
68PBX1_22567123_ChIP-ChIP_OVCAR3_Human1.07116257
69CEBPA_23403033_ChIP-Seq_LIVER_Mouse1.06790885
70PCGF2_27294783_Chip-Seq_NPCs_Mouse1.05084469
71NANOG_20526341_ChIP-Seq_ESCs_Human1.04771638
72EGR1_23403033_ChIP-Seq_LIVER_Mouse1.04594698
73FOXO3_22982991_ChIP-Seq_MACROPHAGES_Mouse1.04110932
74MYC_20876797_ChIP-ChIP_MEDULLOBLASTOMA_Human1.03985442
75FOXM1_25889361_ChIP-Seq_OE33_AND_U2OS_Human1.03195134
76GLI1_17442700_ChIP-ChIP_MESCs_Mouse1.02970854
77FLI1_21571218_ChIP-Seq_MEGAKARYOCYTES_Human1.02604004
78NCOR_22424771_ChIP-Seq_293T_Human1.01963759
79POU5F1_16153702_ChIP-ChIP_HESCs_Human1.00891888
80AUTS2_25519132_ChIP-Seq_293T-REX_Human1.00031332
81PPARG_23326641_ChIP-Seq_C3H10T1-2_Mouse0.98834633
82MYB_26560356_Chip-Seq_TH1_Human0.96902449
83E2F1_18555785_ChIP-Seq_MESCs_Mouse0.95503087
84E2F7_22180533_ChIP-Seq_HELA_Human0.95368904
85EBNA2_21746931_ChIP-Seq_IB4-LCL_Human0.94939540
86RBPJ_21746931_ChIP-Seq_IB4-LCL_Human0.94218734
87CTBP1_25329375_ChIP-Seq_LNCAP_Human0.92762720
88EKLF_21900194_ChIP-Seq_ERYTHROCYTE_Mouse0.91960831
89SPI1_23547873_ChIP-Seq_NB4_Human0.91466671
90GATA3_21878914_ChIP-Seq_MCF-7_Human0.90665951
91NFE2_27457419_Chip-Seq_LIVER_Mouse0.90404340
92GATA3_26560356_Chip-Seq_TH1_Human0.90023686
93ER_23166858_ChIP-Seq_MCF-7_Human0.89796252
94CEBPA_26348894_ChIP-Seq_LIVER_Mouse0.89730446
95TAL1_22897851_ChIP-Seq_JUKARTE6-1_Human0.89037857
96FOXA1_25329375_ChIP-Seq_VCAP_Human0.88960105
97FOXA1_27270436_Chip-Seq_PROSTATE_Human0.88960105
98CTBP2_25329375_ChIP-Seq_LNCAP_Human0.88824843
99HCFC1_20581084_ChIP-Seq_MESCs_Mouse0.87892010
100LMO2_20887958_ChIP-Seq_HPC-7_Mouse0.86724408

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0005671_abnormal_response_to4.72863081
2MP0003786_premature_aging3.42277343
3MP0009785_altered_susceptibility_to2.83486790
4MP0002736_abnormal_nociception_after2.51386852
5MP0003763_abnormal_thymus_physiology2.41651793
6MP0002102_abnormal_ear_morphology2.32115537
7MP0001835_abnormal_antigen_presentation2.31873242
8MP0001968_abnormal_touch/_nociception2.26155221
9MP0002166_altered_tumor_susceptibility2.19303806
10MP0005000_abnormal_immune_tolerance2.14352930
11MP0001800_abnormal_humoral_immune2.12810075
12MP0005377_hearing/vestibular/ear_phenot2.10341973
13MP0003878_abnormal_ear_physiology2.10341973
14MP0000685_abnormal_immune_system2.07513253
15MP0008995_early_reproductive_senescence2.05420225
16MP0003011_delayed_dark_adaptation2.03632458
17MP0005084_abnormal_gallbladder_morpholo2.03168605
18MP0003724_increased_susceptibility_to2.01086354
19MP0003866_abnormal_defecation1.98527790
20MP0001986_abnormal_taste_sensitivity1.95352873
21MP0005646_abnormal_pituitary_gland1.94946502
22MP0002723_abnormal_immune_serum1.94775912
23MP0009333_abnormal_splenocyte_physiolog1.93628852
24MP0002148_abnormal_hypersensitivity_rea1.91739113
25MP0006072_abnormal_retinal_apoptosis1.91640352
26MP0002420_abnormal_adaptive_immunity1.91223753
27MP0001819_abnormal_immune_cell1.87375487
28MP0008872_abnormal_physiological_respon1.77742812
29MP0002006_tumorigenesis1.75727163
30MP0004147_increased_porphyrin_level1.73602152
31MP0001529_abnormal_vocalization1.68839236
32MP0005025_abnormal_response_to1.65995863
33MP0003646_muscle_fatigue1.61480173
34MP0002452_abnormal_antigen_presenting1.57189470
35MP0008058_abnormal_DNA_repair1.54690861
36MP0000372_irregular_coat_pigmentation1.52520875
37MP0008789_abnormal_olfactory_epithelium1.52427012
38MP0005551_abnormal_eye_electrophysiolog1.49002902
39MP0005387_immune_system_phenotype1.48661913
40MP0001790_abnormal_immune_system1.48661913
41MP0002398_abnormal_bone_marrow1.48241494
42MP0005645_abnormal_hypothalamus_physiol1.44139041
43MP0000716_abnormal_immune_system1.41062822
44MP0005075_abnormal_melanosome_morpholog1.30933033
45MP0006054_spinal_hemorrhage1.28124985
46MP0000689_abnormal_spleen_morphology1.26114442
47MP0005253_abnormal_eye_physiology1.24614326
48MP0002405_respiratory_system_inflammati1.22309682
49MP0002722_abnormal_immune_system1.18490623
50MP0006082_CNS_inflammation1.16644803
51MP0002277_abnormal_respiratory_mucosa1.16472620
52MP0001905_abnormal_dopamine_level1.16340847
53MP0003718_maternal_effect1.15687270
54MP0002429_abnormal_blood_cell1.15656046
55MP0010155_abnormal_intestine_physiology1.15213224
56MP0001845_abnormal_inflammatory_respons1.14400654
57MP0000703_abnormal_thymus_morphology1.14035927
58MP0002234_abnormal_pharynx_morphology1.12174747
59MP0003693_abnormal_embryo_hatching1.09934668
60MP0002876_abnormal_thyroid_physiology1.05715177
61MP0008875_abnormal_xenobiotic_pharmacok1.02230691
62MP0003195_calcinosis1.00861921
63MP0006035_abnormal_mitochondrial_morpho1.00072886
64MP0004145_abnormal_muscle_electrophysio0.97968226
65MP0009764_decreased_sensitivity_to0.96946878
66MP0008877_abnormal_DNA_methylation0.96639155
67MP0009765_abnormal_xenobiotic_induced0.95938802
68MP0003567_abnormal_fetal_cardiomyocyte0.95839831
69MP0005410_abnormal_fertilization0.93475653
70MP0010094_abnormal_chromosome_stability0.93342453
71MP0001919_abnormal_reproductive_system0.93204546
72MP0002019_abnormal_tumor_incidence0.90327362
73MP0008469_abnormal_protein_level0.89179044
74MP0006036_abnormal_mitochondrial_physio0.88532902
75MP0001984_abnormal_olfaction0.87492986
76MP0001873_stomach_inflammation0.87248114
77MP0002419_abnormal_innate_immunity0.87190099
78MP0004885_abnormal_endolymph0.85955634
79MP0005389_reproductive_system_phenotype0.85913395
80MP0002653_abnormal_ependyma_morphology0.85907621
81MP0004957_abnormal_blastocyst_morpholog0.85019896
82MP0002095_abnormal_skin_pigmentation0.84444890
83MP0005423_abnormal_somatic_nervous0.81625381
84MP0005167_abnormal_blood-brain_barrier0.79308569
85MP0001542_abnormal_bone_strength0.79170043
86MP0005499_abnormal_olfactory_system0.77267557
87MP0005394_taste/olfaction_phenotype0.77267557
88MP0002638_abnormal_pupillary_reflex0.77172353
89MP0009763_increased_sensitivity_to0.75983071
90MP0002751_abnormal_autonomic_nervous0.75842618
91MP0003806_abnormal_nucleotide_metabolis0.75758132
92MP0003448_altered_tumor_morphology0.71964438
93MP0001188_hyperpigmentation0.71670170
94MP0001853_heart_inflammation0.67690972
95MP0004142_abnormal_muscle_tone0.67317628
96MP0006276_abnormal_autonomic_nervous0.66146832
97MP0001533_abnormal_skeleton_physiology0.64734749
98MP0004947_skin_inflammation0.64155005
99MP0002138_abnormal_hepatobiliary_system0.62472311
100MP0001119_abnormal_female_reproductive0.62085949

Predicted human phenotypes

RankGene SetZ-score
1T lymphocytopenia (HP:0005403)4.58331802
2IgG deficiency (HP:0004315)4.54374977
3Abnormality of T cell number (HP:0011839)4.23267379
4Severe combined immunodeficiency (HP:0004430)3.99614448
5Stomatitis (HP:0010280)3.55751469
6Elevated erythrocyte sedimentation rate (HP:0003565)3.46951074
7Aplastic anemia (HP:0001915)3.26048521
8Combined immunodeficiency (HP:0005387)3.25311386
9Decreased electroretinogram (ERG) amplitude (HP:0000654)3.24959545
10Congenital stationary night blindness (HP:0007642)3.23171859
11Abnormality of T cells (HP:0002843)3.19685131
12Chronic diarrhea (HP:0002028)3.16181723
13Mitochondrial inheritance (HP:0001427)3.13782550
14Methylmalonic acidemia (HP:0002912)3.11438080
15Increased hepatocellular lipid droplets (HP:0006565)3.01935458
16Hepatocellular necrosis (HP:0001404)3.01337039
17Renal Fanconi syndrome (HP:0001994)2.88093514
18Increased CSF lactate (HP:0002490)2.84243781
19Aplasia/hypoplasia of the uterus (HP:0008684)2.83428145
20Methylmalonic aciduria (HP:0012120)2.82545796
21Lipid accumulation in hepatocytes (HP:0006561)2.79482841
22Acute necrotizing encephalopathy (HP:0006965)2.74307964
23Hepatic necrosis (HP:0002605)2.73464950
24Pancreatic cysts (HP:0001737)2.73252624
25Hypoproteinemia (HP:0003075)2.71776267
26Abnormality of the prostate (HP:0008775)2.69911212
27Renal cortical cysts (HP:0000803)2.67357757
28Decreased activity of cytochrome C oxidase in muscle tissue (HP:0003688)2.67100999
29Pancytopenia (HP:0001876)2.62410108
30IgM deficiency (HP:0002850)2.60160428
31Oral leukoplakia (HP:0002745)2.49975798
32Muscle abnormality related to mitochondrial dysfunction (HP:0003800)2.48498979
33Type 2 muscle fiber atrophy (HP:0003554)2.47437519
34Increased serum lactate (HP:0002151)2.46547288
35Thyroiditis (HP:0100646)2.45985198
36Abnormal mitochondria in muscle tissue (HP:0008316)2.45800432
37Increased intramyocellular lipid droplets (HP:0012240)2.43375594
38Abnormality of eosinophils (HP:0001879)2.41014415
39Fused cervical vertebrae (HP:0002949)2.40398715
40Prostate neoplasm (HP:0100787)2.30203170
41Generalized aminoaciduria (HP:0002909)2.27119807
42Myositis (HP:0100614)2.26009147
43Pendular nystagmus (HP:0012043)2.25428810
44Progressive macrocephaly (HP:0004481)2.23211634
45Concave nail (HP:0001598)2.20285057
46Retrobulbar optic neuritis (HP:0100654)2.19224884
47Optic neuritis (HP:0100653)2.19224884
48Neonatal respiratory distress (HP:0002643)2.17967994
49Hyperglycinemia (HP:0002154)2.17769127
50Muscle fiber atrophy (HP:0100295)2.13957563
51Lactic acidosis (HP:0003128)2.13226037
52True hermaphroditism (HP:0010459)2.11948616
53Aplasia/Hypoplasia of the fovea (HP:0008060)2.10793472
54Hypoplasia of the fovea (HP:0007750)2.10793472
55Recurrent cutaneous fungal infections (HP:0011370)2.08510717
56Chronic mucocutaneous candidiasis (HP:0002728)2.08510717
57Autoimmune hemolytic anemia (HP:0001890)2.06251448
58Acute encephalopathy (HP:0006846)2.06205453
59Hypoplasia of the uterus (HP:0000013)2.05900345
60Abnormality of the fovea (HP:0000493)2.04054068
61Joint swelling (HP:0001386)2.03542452
62Abnormal activity of mitochondrial respiratory chain (HP:0011922)2.03092874
63Decreased activity of mitochondrial respiratory chain (HP:0008972)2.03092874
64Attenuation of retinal blood vessels (HP:0007843)2.01209942
653-Methylglutaconic aciduria (HP:0003535)2.00809171
66Increased muscle lipid content (HP:0009058)2.00690831
67Pancreatic fibrosis (HP:0100732)1.99975262
68Congenital, generalized hypertrichosis (HP:0004540)1.98469100
69Progressive inability to walk (HP:0002505)1.97488380
70Abnormality of the renal cortex (HP:0011035)1.97035422
71Lymphopenia (HP:0001888)1.96271473
72Keratoconjunctivitis (HP:0001096)1.96120571
73Symphalangism affecting the phalanges of the hand (HP:0009773)1.95602574
74Unilateral renal agenesis (HP:0000122)1.94448823
75Abnormality of dicarboxylic acid metabolism (HP:0010995)1.94072320
76Dicarboxylic aciduria (HP:0003215)1.94072320
77Abolished electroretinogram (ERG) (HP:0000550)1.93311913
78Decreased central vision (HP:0007663)1.92924688
79Cerebral edema (HP:0002181)1.92866213
80Cerebral palsy (HP:0100021)1.92714539
81Synostosis involving the elbow (HP:0003938)1.90318224
82Humeroradial synostosis (HP:0003041)1.90318224
83Pustule (HP:0200039)1.89453703
84Optic disc pallor (HP:0000543)1.86627510
85Carpal bone hypoplasia (HP:0001498)1.85768760
86Atrophy/Degeneration involving motor neurons (HP:0007373)1.84429384
87Exertional dyspnea (HP:0002875)1.84319679
88Absent rod-and cone-mediated responses on ERG (HP:0007688)1.83300785
89Amyotrophic lateral sclerosis (HP:0007354)1.81008682
90Encephalitis (HP:0002383)1.79472836
91Abnormality of cells of the lymphoid lineage (HP:0012140)1.79407703
92Lissencephaly (HP:0001339)1.78262133
93Abnormality of the vitamin B12 metabolism (HP:0004341)1.77225903
94Thyroid-stimulating hormone excess (HP:0002925)1.77172609
95Abnormality of T cell physiology (HP:0011840)1.76068867
96Brittle hair (HP:0002299)1.76056638
97Abnormality of renal resorption (HP:0011038)1.75928063
98Progressive microcephaly (HP:0000253)1.74463230
99Exercise intolerance (HP:0003546)1.73950172
100Keratoconjunctivitis sicca (HP:0001097)1.73805891

Predicted kinase interactions (KEA)

RankGene SetZ-score
1TXK6.23796440
2MAP4K24.13623230
3KDR3.62932967
4VRK22.99035423
5TESK22.91558436
6TAOK32.78801351
7STK162.73623297
8BCKDK2.32330682
9NUAK12.15056714
10BUB12.12223377
11MAP4K12.00543946
12TLK11.91012140
13TIE11.89580172
14SRPK11.68706351
15ZAK1.65513648
16VRK11.61811520
17EIF2AK31.60226773
18NME11.56302292
19BCR1.48906324
20ADRBK21.47768015
21LIMK11.45836356
22WNK41.45388742
23MAPKAPK31.44043777
24ITK1.43607677
25IKBKE1.34429791
26FES1.34205452
27SYK1.29867584
28CSNK1G31.27822414
29GRK71.25736321
30GRK11.24213162
31TRIM281.23784778
32GRK61.23560016
33MAP3K141.23019247
34STK101.10222705
35TESK11.05812164
36MST41.05178174
37CSNK1A1L1.03496193
38TEC1.01810129
39CSNK1G21.01195357
40GRK51.00102054
41EIF2AK10.96100452
42DAPK10.95395816
43CSNK1G10.90174759
44EPHA30.89546498
45PRKCQ0.86704852
46TAF10.83679398
47STK390.82037681
48CCNB10.80528731
49TBK10.78700109
50MAP2K70.78181702
51PIK3CA0.75038504
52LCK0.74056744
53PASK0.73161101
54MAPKAPK50.73007830
55EIF2AK20.72737124
56PLK30.72689051
57IKBKB0.71366262
58MAPK130.66302503
59LYN0.65251149
60ZAP700.63362172
61TGFBR20.62987609
62RPS6KA50.60661774
63BTK0.60062967
64ERBB30.59285147
65OXSR10.57930072
66NEK20.57086182
67PLK20.56624700
68WNK30.54442524
69MOS0.52358999
70CSF1R0.51572576
71PINK10.50062411
72SIK30.48751383
73AURKA0.47075508
74FRK0.46728785
75MAP2K60.46044352
76IGF1R0.44568539
77DYRK30.43948569
78BMPR1B0.43133263
79PLK40.42828552
80INSRR0.42579998
81CSK0.40287790
82MUSK0.39993187
83AURKB0.39534492
84TSSK60.37174273
85PIM20.36878136
86PIM10.35377311
87NEK10.34130413
88HCK0.33949760
89MATK0.33041624
90ADRBK10.32882591
91CHUK0.32072590
92MAP3K40.31460808
93PLK10.31059230
94JAK30.30661833
95DAPK20.29738386
96CDC70.28245205
97MAPKAPK20.27776546
98INSR0.27186955
99ARAF0.27019859
100CSNK2A10.26617427

Predicted pathways (KEGG)

RankGene SetZ-score
1Proteasome_Homo sapiens_hsa030505.16703358
2Primary immunodeficiency_Homo sapiens_hsa053403.89294447
3Antigen processing and presentation_Homo sapiens_hsa046122.80587645
4Oxidative phosphorylation_Homo sapiens_hsa001902.78650065
5Parkinsons disease_Homo sapiens_hsa050122.54865799
6RNA polymerase_Homo sapiens_hsa030202.46211249
7Protein export_Homo sapiens_hsa030602.23790911
8Graft-versus-host disease_Homo sapiens_hsa053322.13878127
9Autoimmune thyroid disease_Homo sapiens_hsa053202.10522037
10Cytosolic DNA-sensing pathway_Homo sapiens_hsa046232.01431907
11Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005631.96437852
12Allograft rejection_Homo sapiens_hsa053301.95324243
13Natural killer cell mediated cytotoxicity_Homo sapiens_hsa046501.91065212
14Phototransduction_Homo sapiens_hsa047441.87178493
15Spliceosome_Homo sapiens_hsa030401.80386784
16Hematopoietic cell lineage_Homo sapiens_hsa046401.79666381
17Intestinal immune network for IgA production_Homo sapiens_hsa046721.73983747
18Homologous recombination_Homo sapiens_hsa034401.73046316
19Huntingtons disease_Homo sapiens_hsa050161.50381620
20Systemic lupus erythematosus_Homo sapiens_hsa053221.48710581
21Alzheimers disease_Homo sapiens_hsa050101.41281407
22Rheumatoid arthritis_Homo sapiens_hsa053231.38153888
23T cell receptor signaling pathway_Homo sapiens_hsa046601.38105242
24Type I diabetes mellitus_Homo sapiens_hsa049401.38050902
25DNA replication_Homo sapiens_hsa030301.37706322
26Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030081.34297763
27Terpenoid backbone biosynthesis_Homo sapiens_hsa009001.33575904
28Pathogenic Escherichia coli infection_Homo sapiens_hsa051301.30366765
29Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001301.29777936
30Inflammatory bowel disease (IBD)_Homo sapiens_hsa053211.29513415
31Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049321.24410604
32Fanconi anemia pathway_Homo sapiens_hsa034601.22829270
33Propanoate metabolism_Homo sapiens_hsa006401.21576552
34NF-kappa B signaling pathway_Homo sapiens_hsa040641.18106525
35Cytokine-cytokine receptor interaction_Homo sapiens_hsa040601.17615327
36Base excision repair_Homo sapiens_hsa034101.15834557
37Valine, leucine and isoleucine degradation_Homo sapiens_hsa002801.14218161
38Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006041.13477733
39Pyrimidine metabolism_Homo sapiens_hsa002401.12035079
40Basal transcription factors_Homo sapiens_hsa030221.11942800
41Nitrogen metabolism_Homo sapiens_hsa009101.11131072
42Glycine, serine and threonine metabolism_Homo sapiens_hsa002601.09046063
43Non-homologous end-joining_Homo sapiens_hsa034501.05628896
44Asthma_Homo sapiens_hsa053101.03119058
45Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004001.02839397
46Caffeine metabolism_Homo sapiens_hsa002321.00175651
47Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa009700.98691956
48Viral myocarditis_Homo sapiens_hsa054160.97417019
49One carbon pool by folate_Homo sapiens_hsa006700.96998952
50Linoleic acid metabolism_Homo sapiens_hsa005910.96615638
51Selenocompound metabolism_Homo sapiens_hsa004500.95528771
52alpha-Linolenic acid metabolism_Homo sapiens_hsa005920.94246784
53Shigellosis_Homo sapiens_hsa051310.92652748
54RNA transport_Homo sapiens_hsa030130.90897257
55Regulation of autophagy_Homo sapiens_hsa041400.90098783
56Neuroactive ligand-receptor interaction_Homo sapiens_hsa040800.89646569
57Sulfur metabolism_Homo sapiens_hsa009200.88700514
58Purine metabolism_Homo sapiens_hsa002300.88322078
59Tryptophan metabolism_Homo sapiens_hsa003800.87277350
60Butanoate metabolism_Homo sapiens_hsa006500.86176441
61RNA degradation_Homo sapiens_hsa030180.84896242
62Mismatch repair_Homo sapiens_hsa034300.83305854
63Cell adhesion molecules (CAMs)_Homo sapiens_hsa045140.83194830
64Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008600.82135585
65Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005330.81776852
66Peroxisome_Homo sapiens_hsa041460.77471947
67Measles_Homo sapiens_hsa051620.76175854
68Epstein-Barr virus infection_Homo sapiens_hsa051690.68324879
69Fatty acid elongation_Homo sapiens_hsa000620.67868545
70Cardiac muscle contraction_Homo sapiens_hsa042600.66341990
71RIG-I-like receptor signaling pathway_Homo sapiens_hsa046220.65312673
72N-Glycan biosynthesis_Homo sapiens_hsa005100.64459153
73Cysteine and methionine metabolism_Homo sapiens_hsa002700.61746365
74Alcoholism_Homo sapiens_hsa050340.61737395
75Morphine addiction_Homo sapiens_hsa050320.61220513
76Nucleotide excision repair_Homo sapiens_hsa034200.58631074
77Olfactory transduction_Homo sapiens_hsa047400.56142085
78Synthesis and degradation of ketone bodies_Homo sapiens_hsa000720.54972869
79Herpes simplex infection_Homo sapiens_hsa051680.54540787
80Ribosome_Homo sapiens_hsa030100.53846782
81Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006300.52272762
82Ether lipid metabolism_Homo sapiens_hsa005650.45273586
83SNARE interactions in vesicular transport_Homo sapiens_hsa041300.41999044
84Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010400.41707473
85Metabolic pathways_Homo sapiens_hsa011000.41407983
86Jak-STAT signaling pathway_Homo sapiens_hsa046300.40200359
87Arachidonic acid metabolism_Homo sapiens_hsa005900.35739326
88Oocyte meiosis_Homo sapiens_hsa041140.34848908
89Collecting duct acid secretion_Homo sapiens_hsa049660.34183666
90NOD-like receptor signaling pathway_Homo sapiens_hsa046210.33685155
91Viral carcinogenesis_Homo sapiens_hsa052030.32971700
92Nicotine addiction_Homo sapiens_hsa050330.32687028
93Fat digestion and absorption_Homo sapiens_hsa049750.30000938
94Salmonella infection_Homo sapiens_hsa051320.29443110
95beta-Alanine metabolism_Homo sapiens_hsa004100.26258010
96Chemical carcinogenesis_Homo sapiens_hsa052040.25772891
97Citrate cycle (TCA cycle)_Homo sapiens_hsa000200.25362467
98GABAergic synapse_Homo sapiens_hsa047270.25100492
99Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006010.23716842
100Steroid biosynthesis_Homo sapiens_hsa001000.23044945

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