ARCHS4

Functional Annotation Prediction

Predicted biological processes (GO)

Rank	Gene Set	Z-score
1	regulation of single stranded viral RNA replication via double stranded DNA intermediate (GO:0045091	7.65952597
2	DNA deamination (GO:0045006)	7.61559415
3	cytidine catabolic process (GO:0006216)	7.06921233
4	cytidine deamination (GO:0009972)	7.06921233
5	cytidine metabolic process (GO:0046087)	7.06921233
6	pyrimidine ribonucleoside catabolic process (GO:0046133)	6.09520178
7	sequestering of actin monomers (GO:0042989)	5.29987613
8	cellular response to interleukin-15 (GO:0071350)	4.83166662
9	positive regulation of defense response to virus by host (GO:0002230)	4.34209243
10	Arp2/3 complex-mediated actin nucleation (GO:0034314)	4.32635882
11	response to pheromone (GO:0019236)	4.13950880
12	negative T cell selection (GO:0043383)	3.99667262
13	regulation of activation of Janus kinase activity (GO:0010533)	3.93572040
14	actin nucleation (GO:0045010)	3.88187197
15	positive regulation of T cell mediated cytotoxicity (GO:0001916)	3.84293512
16	platelet dense granule organization (GO:0060155)	3.73025668
17	negative regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051436)	3.66311149
18	DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest (GO:00	3.60300542
19	water-soluble vitamin biosynthetic process (GO:0042364)	3.57915100
20	response to interleukin-15 (GO:0070672)	3.57075615
21	DNA demethylation (GO:0080111)	3.54490042
22	regulation of cellular amino acid metabolic process (GO:0006521)	3.52179031
23	positive regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051437)	3.49654493
24	signal transduction involved in mitotic DNA damage checkpoint (GO:1902402)	3.48960007
25	signal transduction involved in mitotic cell cycle checkpoint (GO:0072413)	3.48960007
26	signal transduction involved in mitotic DNA integrity checkpoint (GO:1902403)	3.48960007
27	intracellular signal transduction involved in G1 DNA damage checkpoint (GO:1902400)	3.48938052
28	signal transduction involved in mitotic G1 DNA damage checkpoint (GO:0072431)	3.48938052
29	positive regulation of leukocyte mediated cytotoxicity (GO:0001912)	3.47862634
30	proteasome assembly (GO:0043248)	3.41733407
31	regulation of T cell mediated cytotoxicity (GO:0001914)	3.38761228
32	positive T cell selection (GO:0043368)	3.38463711
33	interferon-gamma production (GO:0032609)	3.35676642
34	signal transduction involved in cell cycle checkpoint (GO:0072395)	3.32869231
35	regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051439)	3.31769491
36	negative regulation of ligase activity (GO:0051352)	3.31448267
37	negative regulation of ubiquitin-protein transferase activity (GO:0051444)	3.31448267
38	signal transduction involved in DNA integrity checkpoint (GO:0072401)	3.31226753
39	signal transduction involved in DNA damage checkpoint (GO:0072422)	3.31226753
40	protein neddylation (GO:0045116)	3.31002297
41	regulation of leukocyte mediated cytotoxicity (GO:0001910)	3.26149603
42	cell wall macromolecule catabolic process (GO:0016998)	3.21118328
43	energy coupled proton transport, down electrochemical gradient (GO:0015985)	3.18937801
44	ATP synthesis coupled proton transport (GO:0015986)	3.18937801
45	regulation of gamma-delta T cell differentiation (GO:0045586)	3.18758050
46	cell wall macromolecule metabolic process (GO:0044036)	3.16906462
47	positive regulation of alpha-beta T cell proliferation (GO:0046641)	3.13913296
48	antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-dependent (GO:	3.12427224
49	anaphase-promoting complex-dependent proteasomal ubiquitin-dependent protein catabolic process (GO:0	3.10745036
50	cellular defense response (GO:0006968)	3.09710615
51	regulation of double-strand break repair via homologous recombination (GO:0010569)	3.09627363
52	tRNA splicing, via endonucleolytic cleavage and ligation (GO:0006388)	3.09115056
53	RNA splicing, via endonucleolytic cleavage and ligation (GO:0000394)	3.09115056
54	positive regulation of cell killing (GO:0031343)	3.07923619
55	mitochondrial ATP synthesis coupled proton transport (GO:0042776)	3.05330116
56	regulation of memory T cell differentiation (GO:0043380)	3.04810247
57	regulation of regulatory T cell differentiation (GO:0045589)	3.03883828
58	positive regulation of natural killer cell mediated immunity (GO:0002717)	3.02733112
59	protein deneddylation (GO:0000338)	3.02659497
60	pyrimidine nucleoside catabolic process (GO:0046135)	3.02279124
61	antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-independent (G	2.99308522
62	positive regulation of ubiquitin-protein transferase activity (GO:0051443)	2.93728689
63	positive regulation of T-helper 1 type immune response (GO:0002827)	2.93090438
64	antigen processing and presentation of exogenous peptide antigen via MHC class I (GO:0042590)	2.92690829
65	regulation of cell killing (GO:0031341)	2.92335440
66	positive regulation of natural killer cell mediated cytotoxicity (GO:0045954)	2.90386177
67	regulation of defense response to virus by host (GO:0050691)	2.86972717
68	regulation of natural killer cell mediated immunity (GO:0002715)	2.84937804
69	regulation of natural killer cell mediated cytotoxicity (GO:0042269)	2.84937804
70	mitochondrial electron transport, NADH to ubiquinone (GO:0006120)	2.84382574
71	negative thymic T cell selection (GO:0045060)	2.82850256
72	positive regulation of ligase activity (GO:0051351)	2.82526491
73	positive regulation of T cell mediated immunity (GO:0002711)	2.80626172
74	negative regulation of mast cell activation (GO:0033004)	2.78142909
75	DNA dealkylation (GO:0035510)	2.74739680
76	cullin deneddylation (GO:0010388)	2.72944694
77	positive regulation of gamma-delta T cell activation (GO:0046645)	2.71094082
78	negative regulation of transcription elongation from RNA polymerase II promoter (GO:0034244)	2.70901572
79	positive regulation of antigen receptor-mediated signaling pathway (GO:0050857)	2.69791088
80	positive regulation of cell cycle arrest (GO:0071158)	2.69647495
81	microtubule depolymerization (GO:0007019)	2.69200865
82	DNA damage response, signal transduction by p53 class mediator (GO:0030330)	2.66999245
83	T cell migration (GO:0072678)	2.66897260
84	ubiquinone metabolic process (GO:0006743)	2.64045464
85	negative regulation by host of viral transcription (GO:0043922)	2.63621568
86	regulation of T cell receptor signaling pathway (GO:0050856)	2.62038002
87	protein complex biogenesis (GO:0070271)	2.60887275
88	dopamine transport (GO:0015872)	2.60325139
89	positive thymic T cell selection (GO:0045059)	2.59947506
90	regulation of cellular amine metabolic process (GO:0033238)	2.59035700
91	negative regulation of viral genome replication (GO:0045071)	2.58261510
92	S-adenosylmethionine metabolic process (GO:0046500)	2.56510088
93	peptidyl-arginine omega-N-methylation (GO:0035247)	2.56123830
94	pyrimidine deoxyribonucleotide catabolic process (GO:0009223)	2.55326255
95	metallo-sulfur cluster assembly (GO:0031163)	2.54524558
96	iron-sulfur cluster assembly (GO:0016226)	2.54524558
97	T cell receptor signaling pathway (GO:0050852)	2.54193523
98	ubiquinone biosynthetic process (GO:0006744)	2.52774050
99	antigen processing and presentation of peptide antigen via MHC class I (GO:0002474)	2.52669943
100	positive regulation of tyrosine phosphorylation of Stat5 protein (GO:0042523)	2.52453033

Predicted upstream transcription factors (ChEA)

Rank	Gene Set	Z-score
1	E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse	4.47084469
2	KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human	4.34524288
3	BP1_19119308_ChIP-ChIP_Hs578T_Human	4.15256479
4	NOTCH1_17114293_ChIP-ChIP_T-ALL_Human	3.67292832
5	GABP_17652178_ChIP-ChIP_JURKAT_Human	3.58587681
6	EST1_17652178_ChIP-ChIP_JURKAT_Human	3.11725229
7	JARID1A_20064375_ChIP-Seq_MESCs_Mouse	2.83954364
8	SOX9_22984422_ChIP-ChIP_TESTIS_Rat	2.76947638
9	ELF1_17652178_ChIP-ChIP_JURKAT_Human	2.74398087
10	HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human	2.64981723
11	VDR_23849224_ChIP-Seq_CD4+_Human	2.59629658
12	IRF1_21803131_ChIP-Seq_MONOCYTES_Human	2.58160162
13	IGF1R_20145208_ChIP-Seq_DFB_Human	2.46487939
14	CHD1_19587682_ChIP-ChIP_MESCs_Mouse	2.44611506
15	STAT6_20620947_ChIP-Seq_CD4_POS_T_Human	2.39808004
16	IRF8_22096565_ChIP-ChIP_GC-B_Mouse	2.39177692
17	SRF_21415370_ChIP-Seq_HL-1_Mouse	2.28414488
18	ZNF274_21170338_ChIP-Seq_K562_Hela	2.26735143
19	ETS1_20019798_ChIP-Seq_JURKAT_Human	2.19963811
20	VDR_22108803_ChIP-Seq_LS180_Human	2.18373992
21	CREB1_15753290_ChIP-ChIP_HEK293T_Human	2.12271700
22	NOTCH1_21737748_ChIP-Seq_TLL_Human	2.07146749
23	CIITA_25753668_ChIP-Seq_RAJI_Human	2.06052303
24	ELK1_19687146_ChIP-ChIP_HELA_Human	2.00056068
25	FOXP3_21729870_ChIP-Seq_TREG_Human	1.97543681
26	MYCN_21190229_ChIP-Seq_SHEP-21N_Human	1.92659254
27	HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse	1.91347185
28	E2F4_17652178_ChIP-ChIP_JURKAT_Human	1.88193404
29	FLI1_27457419_Chip-Seq_LIVER_Mouse	1.84463063
30	MYB_26560356_Chip-Seq_TH2_Human	1.76074150
31	PDX1_19855005_ChIP-ChIP_MIN6_Mouse	1.73629470
32	HOXB4_20404135_ChIP-ChIP_EML_Mouse	1.72734337
33	IRF8_22096565_ChIP-ChIP_GC-B_Human	1.72133172
34	MYBL1_21750041_ChIP-ChIP_SPERMATOCYTES_Mouse	1.63848050
35	YY1_21170310_ChIP-Seq_MESCs_Mouse	1.62812980
36	FOXP3_17237761_ChIP-ChIP_TREG_Mouse	1.61465236
37	LYL1_20887958_ChIP-Seq_HPC-7_Mouse	1.61129172
38	CEBPB_23403033_ChIP-Seq_LIVER_Mouse	1.59338948
39	GATA3_26560356_Chip-Seq_TH2_Human	1.58924557
40	MYC_18940864_ChIP-ChIP_HL60_Human	1.54517091
41	IRF8_21731497_ChIP-ChIP_J774_Mouse	1.51432011
42	SPI1_22096565_ChIP-ChIP_GC-B_Mouse	1.49530102
43	FLI1_20887958_ChIP-Seq_HPC-7_Mouse	1.48584175
44	PAX6_23342162_ChIP-ChIP_BETA-FORBRAIN-LENS_Mouse	1.47694601
45	STAT4_19710469_ChIP-ChIP_TH1__Mouse	1.45142924
46	EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human	1.43041122
47	TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse	1.41592446
48	GATA3_27048872_Chip-Seq_THYMUS_Human	1.39287001
49	DCP1A_22483619_ChIP-Seq_HELA_Human	1.38453360
50	EWS_26573619_Chip-Seq_HEK293_Human	1.37535135
51	RUNX1_20887958_ChIP-Seq_HPC-7_Mouse	1.32966282
52	PADI4_21655091_ChIP-ChIP_MCF-7_Human	1.29133984
53	FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse	1.28999722
54	GABP_19822575_ChIP-Seq_HepG2_Human	1.27557848
55	IRF1_19129219_ChIP-ChIP_H3396_Human	1.26798073
56	PCGF2_27294783_Chip-Seq_ESCs_Mouse	1.26284413
57	AR_20517297_ChIP-Seq_VCAP_Human	1.25439515
58	STAT6_21828071_ChIP-Seq_BEAS2B_Human	1.24924312
59	SPI1_22790984_ChIP-Seq_ERYTHROLEUKEMIA_Mouse	1.21453620
60	POU3F2_20337985_ChIP-ChIP_501MEL_Human	1.19457683
61	RUNX_20019798_ChIP-Seq_JUKART_Human	1.18520928
62	TP53_22573176_ChIP-Seq_HFKS_Human	1.18426373
63	HTT_18923047_ChIP-ChIP_STHdh_Human	1.16612103
64	MYC_18358816_ChIP-ChIP_MESCs_Mouse	1.16499731
65	TAL1_20887958_ChIP-Seq_HPC-7_Mouse	1.15880301
66	ZFP42_18358816_ChIP-ChIP_MESCs_Mouse	1.14985362
67	POU5F1_18358816_ChIP-ChIP_MESCs_Mouse	1.13617492
68	PBX1_22567123_ChIP-ChIP_OVCAR3_Human	1.07116257
69	CEBPA_23403033_ChIP-Seq_LIVER_Mouse	1.06790885
70	PCGF2_27294783_Chip-Seq_NPCs_Mouse	1.05084469
71	NANOG_20526341_ChIP-Seq_ESCs_Human	1.04771638
72	EGR1_23403033_ChIP-Seq_LIVER_Mouse	1.04594698
73	FOXO3_22982991_ChIP-Seq_MACROPHAGES_Mouse	1.04110932
74	MYC_20876797_ChIP-ChIP_MEDULLOBLASTOMA_Human	1.03985442
75	FOXM1_25889361_ChIP-Seq_OE33_AND_U2OS_Human	1.03195134
76	GLI1_17442700_ChIP-ChIP_MESCs_Mouse	1.02970854
77	FLI1_21571218_ChIP-Seq_MEGAKARYOCYTES_Human	1.02604004
78	NCOR_22424771_ChIP-Seq_293T_Human	1.01963759
79	POU5F1_16153702_ChIP-ChIP_HESCs_Human	1.00891888
80	AUTS2_25519132_ChIP-Seq_293T-REX_Human	1.00031332
81	PPARG_23326641_ChIP-Seq_C3H10T1-2_Mouse	0.98834633
82	MYB_26560356_Chip-Seq_TH1_Human	0.96902449
83	E2F1_18555785_ChIP-Seq_MESCs_Mouse	0.95503087
84	E2F7_22180533_ChIP-Seq_HELA_Human	0.95368904
85	EBNA2_21746931_ChIP-Seq_IB4-LCL_Human	0.94939540
86	RBPJ_21746931_ChIP-Seq_IB4-LCL_Human	0.94218734
87	CTBP1_25329375_ChIP-Seq_LNCAP_Human	0.92762720
88	EKLF_21900194_ChIP-Seq_ERYTHROCYTE_Mouse	0.91960831
89	SPI1_23547873_ChIP-Seq_NB4_Human	0.91466671
90	GATA3_21878914_ChIP-Seq_MCF-7_Human	0.90665951
91	NFE2_27457419_Chip-Seq_LIVER_Mouse	0.90404340
92	GATA3_26560356_Chip-Seq_TH1_Human	0.90023686
93	ER_23166858_ChIP-Seq_MCF-7_Human	0.89796252
94	CEBPA_26348894_ChIP-Seq_LIVER_Mouse	0.89730446
95	TAL1_22897851_ChIP-Seq_JUKARTE6-1_Human	0.89037857
96	FOXA1_25329375_ChIP-Seq_VCAP_Human	0.88960105
97	FOXA1_27270436_Chip-Seq_PROSTATE_Human	0.88960105
98	CTBP2_25329375_ChIP-Seq_LNCAP_Human	0.88824843
99	HCFC1_20581084_ChIP-Seq_MESCs_Mouse	0.87892010
100	LMO2_20887958_ChIP-Seq_HPC-7_Mouse	0.86724408

Predicted mouse phenotypes (MGI)

Rank	Gene Set	Z-score
1	MP0005671_abnormal_response_to	4.72863081
2	MP0003786_premature_aging	3.42277343
3	MP0009785_altered_susceptibility_to	2.83486790
4	MP0002736_abnormal_nociception_after	2.51386852
5	MP0003763_abnormal_thymus_physiology	2.41651793
6	MP0002102_abnormal_ear_morphology	2.32115537
7	MP0001835_abnormal_antigen_presentation	2.31873242
8	MP0001968_abnormal_touch/_nociception	2.26155221
9	MP0002166_altered_tumor_susceptibility	2.19303806
10	MP0005000_abnormal_immune_tolerance	2.14352930
11	MP0001800_abnormal_humoral_immune	2.12810075
12	MP0003878_abnormal_ear_physiology	2.10341973
13	MP0005377_hearing/vestibular/ear_phenot	2.10341973
14	MP0000685_abnormal_immune_system	2.07513253
15	MP0008995_early_reproductive_senescence	2.05420225
16	MP0003011_delayed_dark_adaptation	2.03632458
17	MP0005084_abnormal_gallbladder_morpholo	2.03168605
18	MP0003724_increased_susceptibility_to	2.01086354
19	MP0003866_abnormal_defecation	1.98527790
20	MP0001986_abnormal_taste_sensitivity	1.95352873
21	MP0005646_abnormal_pituitary_gland	1.94946502
22	MP0002723_abnormal_immune_serum	1.94775912
23	MP0009333_abnormal_splenocyte_physiolog	1.93628852
24	MP0002148_abnormal_hypersensitivity_rea	1.91739113
25	MP0006072_abnormal_retinal_apoptosis	1.91640352
26	MP0002420_abnormal_adaptive_immunity	1.91223753
27	MP0001819_abnormal_immune_cell	1.87375487
28	MP0008872_abnormal_physiological_respon	1.77742812
29	MP0002006_tumorigenesis	1.75727163
30	MP0004147_increased_porphyrin_level	1.73602152
31	MP0001529_abnormal_vocalization	1.68839236
32	MP0005025_abnormal_response_to	1.65995863
33	MP0003646_muscle_fatigue	1.61480173
34	MP0002452_abnormal_antigen_presenting	1.57189470
35	MP0008058_abnormal_DNA_repair	1.54690861
36	MP0000372_irregular_coat_pigmentation	1.52520875
37	MP0008789_abnormal_olfactory_epithelium	1.52427012
38	MP0005551_abnormal_eye_electrophysiolog	1.49002902
39	MP0001790_abnormal_immune_system	1.48661913
40	MP0005387_immune_system_phenotype	1.48661913
41	MP0002398_abnormal_bone_marrow	1.48241494
42	MP0005645_abnormal_hypothalamus_physiol	1.44139041
43	MP0000716_abnormal_immune_system	1.41062822
44	MP0005075_abnormal_melanosome_morpholog	1.30933033
45	MP0006054_spinal_hemorrhage	1.28124985
46	MP0000689_abnormal_spleen_morphology	1.26114442
47	MP0005253_abnormal_eye_physiology	1.24614326
48	MP0002405_respiratory_system_inflammati	1.22309682
49	MP0002722_abnormal_immune_system	1.18490623
50	MP0006082_CNS_inflammation	1.16644803
51	MP0002277_abnormal_respiratory_mucosa	1.16472620
52	MP0001905_abnormal_dopamine_level	1.16340847
53	MP0003718_maternal_effect	1.15687270
54	MP0002429_abnormal_blood_cell	1.15656046
55	MP0010155_abnormal_intestine_physiology	1.15213224
56	MP0001845_abnormal_inflammatory_respons	1.14400654
57	MP0000703_abnormal_thymus_morphology	1.14035927
58	MP0002234_abnormal_pharynx_morphology	1.12174747
59	MP0003693_abnormal_embryo_hatching	1.09934668
60	MP0002876_abnormal_thyroid_physiology	1.05715177
61	MP0008875_abnormal_xenobiotic_pharmacok	1.02230691
62	MP0003195_calcinosis	1.00861921
63	MP0006035_abnormal_mitochondrial_morpho	1.00072886
64	MP0004145_abnormal_muscle_electrophysio	0.97968226
65	MP0009764_decreased_sensitivity_to	0.96946878
66	MP0008877_abnormal_DNA_methylation	0.96639155
67	MP0009765_abnormal_xenobiotic_induced	0.95938802
68	MP0003567_abnormal_fetal_cardiomyocyte	0.95839831
69	MP0005410_abnormal_fertilization	0.93475653
70	MP0010094_abnormal_chromosome_stability	0.93342453
71	MP0001919_abnormal_reproductive_system	0.93204546
72	MP0002019_abnormal_tumor_incidence	0.90327362
73	MP0008469_abnormal_protein_level	0.89179044
74	MP0006036_abnormal_mitochondrial_physio	0.88532902
75	MP0001984_abnormal_olfaction	0.87492986
76	MP0001873_stomach_inflammation	0.87248114
77	MP0002419_abnormal_innate_immunity	0.87190099
78	MP0004885_abnormal_endolymph	0.85955634
79	MP0005389_reproductive_system_phenotype	0.85913395
80	MP0002653_abnormal_ependyma_morphology	0.85907621
81	MP0004957_abnormal_blastocyst_morpholog	0.85019896
82	MP0002095_abnormal_skin_pigmentation	0.84444890
83	MP0005423_abnormal_somatic_nervous	0.81625381
84	MP0005167_abnormal_blood-brain_barrier	0.79308569
85	MP0001542_abnormal_bone_strength	0.79170043
86	MP0005394_taste/olfaction_phenotype	0.77267557
87	MP0005499_abnormal_olfactory_system	0.77267557
88	MP0002638_abnormal_pupillary_reflex	0.77172353
89	MP0009763_increased_sensitivity_to	0.75983071
90	MP0002751_abnormal_autonomic_nervous	0.75842618
91	MP0003806_abnormal_nucleotide_metabolis	0.75758132
92	MP0003448_altered_tumor_morphology	0.71964438
93	MP0001188_hyperpigmentation	0.71670170
94	MP0001853_heart_inflammation	0.67690972
95	MP0004142_abnormal_muscle_tone	0.67317628
96	MP0006276_abnormal_autonomic_nervous	0.66146832
97	MP0001533_abnormal_skeleton_physiology	0.64734749
98	MP0004947_skin_inflammation	0.64155005
99	MP0002138_abnormal_hepatobiliary_system	0.62472311
100	MP0001119_abnormal_female_reproductive	0.62085949

Predicted human phenotypes

Rank	Gene Set	Z-score
1	T lymphocytopenia (HP:0005403)	4.58331802
2	IgG deficiency (HP:0004315)	4.54374977
3	Abnormality of T cell number (HP:0011839)	4.23267379
4	Severe combined immunodeficiency (HP:0004430)	3.99614448
5	Stomatitis (HP:0010280)	3.55751469
6	Elevated erythrocyte sedimentation rate (HP:0003565)	3.46951074
7	Aplastic anemia (HP:0001915)	3.26048521
8	Combined immunodeficiency (HP:0005387)	3.25311386
9	Decreased electroretinogram (ERG) amplitude (HP:0000654)	3.24959545
10	Congenital stationary night blindness (HP:0007642)	3.23171859
11	Abnormality of T cells (HP:0002843)	3.19685131
12	Chronic diarrhea (HP:0002028)	3.16181723
13	Mitochondrial inheritance (HP:0001427)	3.13782550
14	Methylmalonic acidemia (HP:0002912)	3.11438080
15	Increased hepatocellular lipid droplets (HP:0006565)	3.01935458
16	Hepatocellular necrosis (HP:0001404)	3.01337039
17	Renal Fanconi syndrome (HP:0001994)	2.88093514
18	Increased CSF lactate (HP:0002490)	2.84243781
19	Aplasia/hypoplasia of the uterus (HP:0008684)	2.83428145
20	Methylmalonic aciduria (HP:0012120)	2.82545796
21	Lipid accumulation in hepatocytes (HP:0006561)	2.79482841
22	Acute necrotizing encephalopathy (HP:0006965)	2.74307964
23	Hepatic necrosis (HP:0002605)	2.73464950
24	Pancreatic cysts (HP:0001737)	2.73252624
25	Hypoproteinemia (HP:0003075)	2.71776267
26	Abnormality of the prostate (HP:0008775)	2.69911212
27	Renal cortical cysts (HP:0000803)	2.67357757
28	Decreased activity of cytochrome C oxidase in muscle tissue (HP:0003688)	2.67100999
29	Pancytopenia (HP:0001876)	2.62410108
30	IgM deficiency (HP:0002850)	2.60160428
31	Oral leukoplakia (HP:0002745)	2.49975798
32	Muscle abnormality related to mitochondrial dysfunction (HP:0003800)	2.48498979
33	Type 2 muscle fiber atrophy (HP:0003554)	2.47437519
34	Increased serum lactate (HP:0002151)	2.46547288
35	Thyroiditis (HP:0100646)	2.45985198
36	Abnormal mitochondria in muscle tissue (HP:0008316)	2.45800432
37	Increased intramyocellular lipid droplets (HP:0012240)	2.43375594
38	Abnormality of eosinophils (HP:0001879)	2.41014415
39	Fused cervical vertebrae (HP:0002949)	2.40398715
40	Prostate neoplasm (HP:0100787)	2.30203170
41	Generalized aminoaciduria (HP:0002909)	2.27119807
42	Myositis (HP:0100614)	2.26009147
43	Pendular nystagmus (HP:0012043)	2.25428810
44	Progressive macrocephaly (HP:0004481)	2.23211634
45	Concave nail (HP:0001598)	2.20285057
46	Retrobulbar optic neuritis (HP:0100654)	2.19224884
47	Optic neuritis (HP:0100653)	2.19224884
48	Neonatal respiratory distress (HP:0002643)	2.17967994
49	Hyperglycinemia (HP:0002154)	2.17769127
50	Muscle fiber atrophy (HP:0100295)	2.13957563
51	Lactic acidosis (HP:0003128)	2.13226037
52	True hermaphroditism (HP:0010459)	2.11948616
53	Hypoplasia of the fovea (HP:0007750)	2.10793472
54	Aplasia/Hypoplasia of the fovea (HP:0008060)	2.10793472
55	Chronic mucocutaneous candidiasis (HP:0002728)	2.08510717
56	Recurrent cutaneous fungal infections (HP:0011370)	2.08510717
57	Autoimmune hemolytic anemia (HP:0001890)	2.06251448
58	Acute encephalopathy (HP:0006846)	2.06205453
59	Hypoplasia of the uterus (HP:0000013)	2.05900345
60	Abnormality of the fovea (HP:0000493)	2.04054068
61	Joint swelling (HP:0001386)	2.03542452
62	Abnormal activity of mitochondrial respiratory chain (HP:0011922)	2.03092874
63	Decreased activity of mitochondrial respiratory chain (HP:0008972)	2.03092874
64	Attenuation of retinal blood vessels (HP:0007843)	2.01209942
65	3-Methylglutaconic aciduria (HP:0003535)	2.00809171
66	Increased muscle lipid content (HP:0009058)	2.00690831
67	Pancreatic fibrosis (HP:0100732)	1.99975262
68	Congenital, generalized hypertrichosis (HP:0004540)	1.98469100
69	Progressive inability to walk (HP:0002505)	1.97488380
70	Abnormality of the renal cortex (HP:0011035)	1.97035422
71	Lymphopenia (HP:0001888)	1.96271473
72	Keratoconjunctivitis (HP:0001096)	1.96120571
73	Symphalangism affecting the phalanges of the hand (HP:0009773)	1.95602574
74	Unilateral renal agenesis (HP:0000122)	1.94448823
75	Dicarboxylic aciduria (HP:0003215)	1.94072320
76	Abnormality of dicarboxylic acid metabolism (HP:0010995)	1.94072320
77	Abolished electroretinogram (ERG) (HP:0000550)	1.93311913
78	Decreased central vision (HP:0007663)	1.92924688
79	Cerebral edema (HP:0002181)	1.92866213
80	Cerebral palsy (HP:0100021)	1.92714539
81	Synostosis involving the elbow (HP:0003938)	1.90318224
82	Humeroradial synostosis (HP:0003041)	1.90318224
83	Pustule (HP:0200039)	1.89453703
84	Optic disc pallor (HP:0000543)	1.86627510
85	Carpal bone hypoplasia (HP:0001498)	1.85768760
86	Atrophy/Degeneration involving motor neurons (HP:0007373)	1.84429384
87	Exertional dyspnea (HP:0002875)	1.84319679
88	Absent rod-and cone-mediated responses on ERG (HP:0007688)	1.83300785
89	Amyotrophic lateral sclerosis (HP:0007354)	1.81008682
90	Encephalitis (HP:0002383)	1.79472836
91	Abnormality of cells of the lymphoid lineage (HP:0012140)	1.79407703
92	Lissencephaly (HP:0001339)	1.78262133
93	Abnormality of the vitamin B12 metabolism (HP:0004341)	1.77225903
94	Thyroid-stimulating hormone excess (HP:0002925)	1.77172609
95	Abnormality of T cell physiology (HP:0011840)	1.76068867
96	Brittle hair (HP:0002299)	1.76056638
97	Abnormality of renal resorption (HP:0011038)	1.75928063
98	Progressive microcephaly (HP:0000253)	1.74463230
99	Exercise intolerance (HP:0003546)	1.73950172
100	Keratoconjunctivitis sicca (HP:0001097)	1.73805891

Predicted kinase interactions (KEA)

Rank	Gene Set	Z-score
1	TXK	6.23796440
2	MAP4K2	4.13623230
3	KDR	3.62932967
4	VRK2	2.99035423
5	TESK2	2.91558436
6	TAOK3	2.78801351
7	STK16	2.73623297
8	BCKDK	2.32330682
9	NUAK1	2.15056714
10	BUB1	2.12223377
11	MAP4K1	2.00543946
12	TLK1	1.91012140
13	TIE1	1.89580172
14	SRPK1	1.68706351
15	ZAK	1.65513648
16	VRK1	1.61811520
17	EIF2AK3	1.60226773
18	NME1	1.56302292
19	BCR	1.48906324
20	ADRBK2	1.47768015
21	LIMK1	1.45836356
22	WNK4	1.45388742
23	MAPKAPK3	1.44043777
24	ITK	1.43607677
25	IKBKE	1.34429791
26	FES	1.34205452
27	SYK	1.29867584
28	CSNK1G3	1.27822414
29	GRK7	1.25736321
30	GRK1	1.24213162
31	TRIM28	1.23784778
32	GRK6	1.23560016
33	MAP3K14	1.23019247
34	STK10	1.10222705
35	TESK1	1.05812164
36	MST4	1.05178174
37	CSNK1A1L	1.03496193
38	TEC	1.01810129
39	CSNK1G2	1.01195357
40	GRK5	1.00102054
41	EIF2AK1	0.96100452
42	DAPK1	0.95395816
43	CSNK1G1	0.90174759
44	EPHA3	0.89546498
45	PRKCQ	0.86704852
46	TAF1	0.83679398
47	STK39	0.82037681
48	CCNB1	0.80528731
49	TBK1	0.78700109
50	MAP2K7	0.78181702
51	PIK3CA	0.75038504
52	LCK	0.74056744
53	PASK	0.73161101
54	MAPKAPK5	0.73007830
55	EIF2AK2	0.72737124
56	PLK3	0.72689051
57	IKBKB	0.71366262
58	MAPK13	0.66302503
59	LYN	0.65251149
60	ZAP70	0.63362172
61	TGFBR2	0.62987609
62	RPS6KA5	0.60661774
63	BTK	0.60062967
64	ERBB3	0.59285147
65	OXSR1	0.57930072
66	NEK2	0.57086182
67	PLK2	0.56624700
68	WNK3	0.54442524
69	MOS	0.52358999
70	CSF1R	0.51572576
71	PINK1	0.50062411
72	SIK3	0.48751383
73	AURKA	0.47075508
74	FRK	0.46728785
75	MAP2K6	0.46044352
76	IGF1R	0.44568539
77	DYRK3	0.43948569
78	BMPR1B	0.43133263
79	PLK4	0.42828552
80	INSRR	0.42579998
81	CSK	0.40287790
82	MUSK	0.39993187
83	AURKB	0.39534492
84	TSSK6	0.37174273
85	PIM2	0.36878136
86	PIM1	0.35377311
87	NEK1	0.34130413
88	HCK	0.33949760
89	MATK	0.33041624
90	ADRBK1	0.32882591
91	CHUK	0.32072590
92	MAP3K4	0.31460808
93	PLK1	0.31059230
94	JAK3	0.30661833
95	DAPK2	0.29738386
96	CDC7	0.28245205
97	MAPKAPK2	0.27776546
98	INSR	0.27186955
99	ARAF	0.27019859
100	CSNK2A1	0.26617427

Predicted pathways (KEGG)

Rank	Gene Set	Z-score
1	Proteasome_Homo sapiens_hsa03050	5.16703358
2	Primary immunodeficiency_Homo sapiens_hsa05340	3.89294447
3	Antigen processing and presentation_Homo sapiens_hsa04612	2.80587645
4	Oxidative phosphorylation_Homo sapiens_hsa00190	2.78650065
5	Parkinsons disease_Homo sapiens_hsa05012	2.54865799
6	RNA polymerase_Homo sapiens_hsa03020	2.46211249
7	Protein export_Homo sapiens_hsa03060	2.23790911
8	Graft-versus-host disease_Homo sapiens_hsa05332	2.13878127
9	Autoimmune thyroid disease_Homo sapiens_hsa05320	2.10522037
10	Cytosolic DNA-sensing pathway_Homo sapiens_hsa04623	2.01431907
11	Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa00563	1.96437852
12	Allograft rejection_Homo sapiens_hsa05330	1.95324243
13	Natural killer cell mediated cytotoxicity_Homo sapiens_hsa04650	1.91065212
14	Phototransduction_Homo sapiens_hsa04744	1.87178493
15	Spliceosome_Homo sapiens_hsa03040	1.80386784
16	Hematopoietic cell lineage_Homo sapiens_hsa04640	1.79666381
17	Intestinal immune network for IgA production_Homo sapiens_hsa04672	1.73983747
18	Homologous recombination_Homo sapiens_hsa03440	1.73046316
19	Huntingtons disease_Homo sapiens_hsa05016	1.50381620
20	Systemic lupus erythematosus_Homo sapiens_hsa05322	1.48710581
21	Alzheimers disease_Homo sapiens_hsa05010	1.41281407
22	Rheumatoid arthritis_Homo sapiens_hsa05323	1.38153888
23	T cell receptor signaling pathway_Homo sapiens_hsa04660	1.38105242
24	Type I diabetes mellitus_Homo sapiens_hsa04940	1.38050902
25	DNA replication_Homo sapiens_hsa03030	1.37706322
26	Ribosome biogenesis in eukaryotes_Homo sapiens_hsa03008	1.34297763
27	Terpenoid backbone biosynthesis_Homo sapiens_hsa00900	1.33575904
28	Pathogenic Escherichia coli infection_Homo sapiens_hsa05130	1.30366765
29	Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa00130	1.29777936
30	Inflammatory bowel disease (IBD)_Homo sapiens_hsa05321	1.29513415
31	Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa04932	1.24410604
32	Fanconi anemia pathway_Homo sapiens_hsa03460	1.22829270
33	Propanoate metabolism_Homo sapiens_hsa00640	1.21576552
34	NF-kappa B signaling pathway_Homo sapiens_hsa04064	1.18106525
35	Cytokine-cytokine receptor interaction_Homo sapiens_hsa04060	1.17615327
36	Base excision repair_Homo sapiens_hsa03410	1.15834557
37	Valine, leucine and isoleucine degradation_Homo sapiens_hsa00280	1.14218161
38	Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa00604	1.13477733
39	Pyrimidine metabolism_Homo sapiens_hsa00240	1.12035079
40	Basal transcription factors_Homo sapiens_hsa03022	1.11942800
41	Nitrogen metabolism_Homo sapiens_hsa00910	1.11131072
42	Glycine, serine and threonine metabolism_Homo sapiens_hsa00260	1.09046063
43	Non-homologous end-joining_Homo sapiens_hsa03450	1.05628896
44	Asthma_Homo sapiens_hsa05310	1.03119058
45	Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa00400	1.02839397
46	Caffeine metabolism_Homo sapiens_hsa00232	1.00175651
47	Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa00970	0.98691956
48	Viral myocarditis_Homo sapiens_hsa05416	0.97417019
49	One carbon pool by folate_Homo sapiens_hsa00670	0.96998952
50	Linoleic acid metabolism_Homo sapiens_hsa00591	0.96615638
51	Selenocompound metabolism_Homo sapiens_hsa00450	0.95528771
52	alpha-Linolenic acid metabolism_Homo sapiens_hsa00592	0.94246784
53	Shigellosis_Homo sapiens_hsa05131	0.92652748
54	RNA transport_Homo sapiens_hsa03013	0.90897257
55	Regulation of autophagy_Homo sapiens_hsa04140	0.90098783
56	Neuroactive ligand-receptor interaction_Homo sapiens_hsa04080	0.89646569
57	Sulfur metabolism_Homo sapiens_hsa00920	0.88700514
58	Purine metabolism_Homo sapiens_hsa00230	0.88322078
59	Tryptophan metabolism_Homo sapiens_hsa00380	0.87277350
60	Butanoate metabolism_Homo sapiens_hsa00650	0.86176441
61	RNA degradation_Homo sapiens_hsa03018	0.84896242
62	Mismatch repair_Homo sapiens_hsa03430	0.83305854
63	Cell adhesion molecules (CAMs)_Homo sapiens_hsa04514	0.83194830
64	Porphyrin and chlorophyll metabolism_Homo sapiens_hsa00860	0.82135585
65	Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa00533	0.81776852
66	Peroxisome_Homo sapiens_hsa04146	0.77471947
67	Measles_Homo sapiens_hsa05162	0.76175854
68	Epstein-Barr virus infection_Homo sapiens_hsa05169	0.68324879
69	Fatty acid elongation_Homo sapiens_hsa00062	0.67868545
70	Cardiac muscle contraction_Homo sapiens_hsa04260	0.66341990
71	RIG-I-like receptor signaling pathway_Homo sapiens_hsa04622	0.65312673
72	N-Glycan biosynthesis_Homo sapiens_hsa00510	0.64459153
73	Cysteine and methionine metabolism_Homo sapiens_hsa00270	0.61746365
74	Alcoholism_Homo sapiens_hsa05034	0.61737395
75	Morphine addiction_Homo sapiens_hsa05032	0.61220513
76	Nucleotide excision repair_Homo sapiens_hsa03420	0.58631074
77	Olfactory transduction_Homo sapiens_hsa04740	0.56142085
78	Synthesis and degradation of ketone bodies_Homo sapiens_hsa00072	0.54972869
79	Herpes simplex infection_Homo sapiens_hsa05168	0.54540787
80	Ribosome_Homo sapiens_hsa03010	0.53846782
81	Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa00630	0.52272762
82	Ether lipid metabolism_Homo sapiens_hsa00565	0.45273586
83	SNARE interactions in vesicular transport_Homo sapiens_hsa04130	0.41999044
84	Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa01040	0.41707473
85	Metabolic pathways_Homo sapiens_hsa01100	0.41407983
86	Jak-STAT signaling pathway_Homo sapiens_hsa04630	0.40200359
87	Arachidonic acid metabolism_Homo sapiens_hsa00590	0.35739326
88	Oocyte meiosis_Homo sapiens_hsa04114	0.34848908
89	Collecting duct acid secretion_Homo sapiens_hsa04966	0.34183666
90	NOD-like receptor signaling pathway_Homo sapiens_hsa04621	0.33685155
91	Viral carcinogenesis_Homo sapiens_hsa05203	0.32971700
92	Nicotine addiction_Homo sapiens_hsa05033	0.32687028
93	Fat digestion and absorption_Homo sapiens_hsa04975	0.30000938
94	Salmonella infection_Homo sapiens_hsa05132	0.29443110
95	beta-Alanine metabolism_Homo sapiens_hsa00410	0.26258010
96	Chemical carcinogenesis_Homo sapiens_hsa05204	0.25772891
97	Citrate cycle (TCA cycle)_Homo sapiens_hsa00020	0.25362467
98	GABAergic synapse_Homo sapiens_hsa04727	0.25100492
99	Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa00601	0.23716842
100	Steroid biosynthesis_Homo sapiens_hsa00100	0.23044945

HNRNPKP4

Functional Annotation Prediction

Predicted biological processes (GO)

Predicted upstream transcription factors (ChEA)

Predicted mouse phenotypes (MGI)

Predicted human phenotypes

Predicted kinase interactions (KEA)

Predicted pathways (KEGG)

Most similar genes based on co-expression Upload to Enrichr

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