HNRNPL

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: Heterogeneous nuclear RNAs (hnRNAs) which include mRNA precursors and mature mRNAs are associated with specific proteins to form heterogenous ribonucleoprotein (hnRNP) complexes. Heterogeneous nuclear ribonucleoprotein L is among the proteins that are stably associated with hnRNP complexes and along with other hnRNP proteins is likely to play a major role in the formation, packaging, processing, and function of mRNA. Heterogeneous nuclear ribonucleoprotein L is present in the nucleoplasm as part of the HNRP complex. HNRP proteins have also been identified outside of the nucleoplasm. Exchange of hnRNP for mRNA-binding proteins accompanies transport of mRNA from the nucleus to the cytoplasm. Since HNRP proteins have been shown to shuttle between the nucleus and the cytoplasm, it is possible that they also have cytoplasmic functions. Two transcript variants encoding different isoforms have been found for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1nuclear pore complex assembly (GO:0051292)4.89733203
2nuclear pore organization (GO:0006999)4.78359043
3pre-miRNA processing (GO:0031054)4.77209130
4DNA unwinding involved in DNA replication (GO:0006268)4.38363256
5heterochromatin organization (GO:0070828)4.33851824
6regulation of translational fidelity (GO:0006450)3.95606428
7protein localization to kinetochore (GO:0034501)3.93373152
8negative regulation of mRNA splicing, via spliceosome (GO:0048025)3.91664406
9regulation of mammary gland epithelial cell proliferation (GO:0033599)3.87953894
10dosage compensation (GO:0007549)3.87401833
11negative regulation of histone methylation (GO:0031061)3.85710568
12regulation of gene silencing by RNA (GO:0060966)3.85468648
13regulation of posttranscriptional gene silencing (GO:0060147)3.85468648
14regulation of gene silencing by miRNA (GO:0060964)3.85468648
15RNA stabilization (GO:0043489)3.78362688
16mRNA stabilization (GO:0048255)3.78362688
17chromatin assembly (GO:0031497)3.78298974
18negative regulation of erythrocyte differentiation (GO:0045647)3.74540098
19Golgi transport vesicle coating (GO:0048200)3.67200088
20COPI coating of Golgi vesicle (GO:0048205)3.67200088
21peptidyl-lysine dimethylation (GO:0018027)3.65592827
22regulation of histone H3-K9 methylation (GO:0051570)3.57015753
23pore complex assembly (GO:0046931)3.54222620
24sister chromatid segregation (GO:0000819)3.48846880
25glucocorticoid receptor signaling pathway (GO:0042921)3.44051562
26negative regulation of mRNA processing (GO:0050686)3.41909898
27mitotic nuclear envelope disassembly (GO:0007077)3.41785795
28negative regulation of RNA splicing (GO:0033119)3.41394937
29spliceosomal tri-snRNP complex assembly (GO:0000244)3.41032227
30DNA duplex unwinding (GO:0032508)3.37592708
31mitotic sister chromatid cohesion (GO:0007064)3.36101150
32regulation of histone H3-K27 methylation (GO:0061085)3.36072522
33DNA geometric change (GO:0032392)3.34865553
34DNA replication-dependent nucleosome assembly (GO:0006335)3.32129755
35DNA replication-dependent nucleosome organization (GO:0034723)3.32129755
36paraxial mesoderm development (GO:0048339)3.31333556
37proline biosynthetic process (GO:0006561)3.30746057
38NLS-bearing protein import into nucleus (GO:0006607)3.30235080
39regulation of NFAT protein import into nucleus (GO:0051532)3.29570781
40protein complex localization (GO:0031503)3.27586487
41DNA replication initiation (GO:0006270)3.27462020
42nuclear envelope disassembly (GO:0051081)3.26752472
43membrane disassembly (GO:0030397)3.26752472
44regulation of translational termination (GO:0006449)3.26021149
45regulation of RNA export from nucleus (GO:0046831)3.24544772
46chromosome condensation (GO:0030261)3.22332672
47negative regulation of mRNA metabolic process (GO:1903312)3.21145607
48focal adhesion assembly (GO:0048041)3.19911278
49cell-substrate adherens junction assembly (GO:0007045)3.19911278
50activation of Rac GTPase activity (GO:0032863)3.19676130
51regulation of hippo signaling (GO:0035330)3.19116777
52mitotic chromosome condensation (GO:0007076)3.18592959
53establishment of apical/basal cell polarity (GO:0035089)3.18253497
54mitotic sister chromatid segregation (GO:0000070)3.17535113
55positive regulation of SMAD protein import into nucleus (GO:0060391)3.15842567
56protein localization to chromosome, centromeric region (GO:0071459)3.14015301
57DNA strand elongation involved in DNA replication (GO:0006271)3.13586672
58regulation of sister chromatid cohesion (GO:0007063)3.12121217
59embryonic process involved in female pregnancy (GO:0060136)3.11913933
60positive regulation of RNA splicing (GO:0033120)3.11685156
61positive regulation of histone deacetylation (GO:0031065)3.11451545
62DNA strand elongation (GO:0022616)3.06041495
63DNA topological change (GO:0006265)3.05893361
64folic acid-containing compound biosynthetic process (GO:0009396)3.05005227
65protein export from nucleus (GO:0006611)3.04596830
66cellular protein complex localization (GO:0034629)3.04082078
67formation of translation preinitiation complex (GO:0001731)3.03981640
68histone H2A monoubiquitination (GO:0035518)3.01366342
69cytoplasmic mRNA processing body assembly (GO:0033962)2.99072671
70regulation of glucose import in response to insulin stimulus (GO:2001273)2.94826806
71regulation of attachment of spindle microtubules to kinetochore (GO:0051988)2.93187549
72trophectodermal cell differentiation (GO:0001829)2.92419151
73regulation of mRNA stability (GO:0043488)2.92335134
74positive regulation of chromosome segregation (GO:0051984)2.85740113
75intracellular estrogen receptor signaling pathway (GO:0030520)2.83303429
763-UTR-mediated mRNA stabilization (GO:0070935)2.83119084
77positive regulation of gene expression, epigenetic (GO:0045815)2.82764935
78maternal placenta development (GO:0001893)2.82613417
79peptidyl-arginine omega-N-methylation (GO:0035247)2.82336523
80mitotic G1 DNA damage checkpoint (GO:0031571)2.81831794
81regulation of gene silencing (GO:0060968)2.81506394
82protein-DNA complex disassembly (GO:0032986)2.80930573
83nucleosome disassembly (GO:0006337)2.80930573
84IMP biosynthetic process (GO:0006188)2.76456837
85polarized epithelial cell differentiation (GO:0030859)2.76205672
86histone H3-K36 demethylation (GO:0070544)2.75946776
87negative regulation of histone modification (GO:0031057)2.75611880
88regulation of single stranded viral RNA replication via double stranded DNA intermediate (GO:00450912.75237147
89apoptotic process involved in morphogenesis (GO:0060561)2.74952212
90gene silencing (GO:0016458)2.74537115
91cellular response to epidermal growth factor stimulus (GO:0071364)2.73730622
92corticosteroid receptor signaling pathway (GO:0031958)2.73273261
93protein localization to endosome (GO:0036010)2.72809896
94chromatin silencing (GO:0006342)2.72455945
95regulation of early endosome to late endosome transport (GO:2000641)2.72255140
96nuclear envelope organization (GO:0006998)2.70863667
97nuclear-transcribed mRNA poly(A) tail shortening (GO:0000289)2.70726251
98pentose-phosphate shunt (GO:0006098)2.69889857
99positive regulation of mitochondrial outer membrane permeabilization involved in apoptotic signaling2.69324704
100alternative mRNA splicing, via spliceosome (GO:0000380)2.69176122
101regulation of RNA stability (GO:0043487)2.69117277
102regulation of SMAD protein import into nucleus (GO:0060390)2.67812755
103gene silencing by RNA (GO:0031047)2.66862570
104adherens junction assembly (GO:0034333)2.66366582
105ribosomal small subunit biogenesis (GO:0042274)2.66158188
106histone H3-K9 demethylation (GO:0033169)2.65011360
107positive regulation of mitotic sister chromatid separation (GO:1901970)2.64415007
108positive regulation of mitotic metaphase/anaphase transition (GO:0045842)2.64415007
109positive regulation of metaphase/anaphase transition of cell cycle (GO:1902101)2.64415007
110planar cell polarity pathway involved in neural tube closure (GO:0090179)2.64313962
111peptidyl-arginine N-methylation (GO:0035246)2.64266231
112peptidyl-arginine methylation (GO:0018216)2.64266231
113cellular hyperosmotic response (GO:0071474)2.63746069
114retrograde vesicle-mediated transport, Golgi to ER (GO:0006890)2.62732588
115regulation of chromatin binding (GO:0035561)2.62575664
116DNA packaging (GO:0006323)2.62518188
117establishment of monopolar cell polarity (GO:0061162)2.60262561
118establishment or maintenance of monopolar cell polarity (GO:0061339)2.60262561
119negative regulation of chromatin modification (GO:1903309)2.59582632
120regulation of nucleobase-containing compound transport (GO:0032239)2.59220016
121hippo signaling (GO:0035329)2.59187279
122regulation of DNA damage checkpoint (GO:2000001)2.58566013
123regulation of mitotic spindle organization (GO:0060236)2.57874663
124DNA conformation change (GO:0071103)2.57511490
125negative regulation of DNA repair (GO:0045738)2.57129671
126histone lysine demethylation (GO:0070076)2.56933499
127histone arginine methylation (GO:0034969)2.56929109
128regulation of establishment of planar polarity involved in neural tube closure (GO:0090178)2.56765361
129mRNA transport (GO:0051028)2.56086445
130negative regulation of gene expression, epigenetic (GO:0045814)2.55393508
131maintenance of protein localization in endoplasmic reticulum (GO:0035437)2.55188454
132cytoskeletal anchoring at plasma membrane (GO:0007016)2.54825847
133histone H4-K12 acetylation (GO:0043983)2.53130069
134negative regulation of cell size (GO:0045792)2.53129501
135chromatin assembly or disassembly (GO:0006333)2.50366188
136protein retention in ER lumen (GO:0006621)2.49910589
137cell-substrate junction assembly (GO:0007044)2.48108029
138regulation of transcription involved in G1/S transition of mitotic cell cycle (GO:0000083)2.47953063
139G1 DNA damage checkpoint (GO:0044783)2.46745598
140DNA synthesis involved in DNA repair (GO:0000731)2.46243262
141epithelial cell differentiation involved in prostate gland development (GO:0060742)2.45503442
142regulation of protein insertion into mitochondrial membrane involved in apoptotic signaling pathway 2.39046309

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1E2F7_22180533_ChIP-Seq_HELA_Human7.77719886
2FOXM1_23109430_ChIP-Seq_U2OS_Human5.10585904
3EGR1_19374776_ChIP-ChIP_THP-1_Human4.00159751
4* MYC_22102868_ChIP-Seq_BL_Human3.62021088
5NUCKS1_24931609_ChIP-Seq_HEPATOCYTES_Mouse3.37905562
6E2F4_17652178_ChIP-ChIP_JURKAT_Human2.81829443
7* FOXM1_25889361_ChIP-Seq_OE33_AND_U2OS_Human2.26806909
8VDR_21846776_ChIP-Seq_THP-1_Human2.24944882
9SMAD1_18555785_ChIP-Seq_MESCs_Mouse2.17049417
10ZFP281_18358816_ChIP-ChIP_MESCs_Mouse2.11791775
11* TCF7_22412390_ChIP-Seq_EML_Mouse2.11670923
12HCFC1_20581084_ChIP-Seq_MESCs_Mouse2.11408871
13EKLF_21900194_ChIP-Seq_ERYTHROCYTE_Mouse2.10610574
14* KDM2B_26808549_Chip-Seq_DND41_Human2.07622040
15KDM5B_21448134_ChIP-Seq_MESCs_Mouse2.00744868
16MYC_18555785_ChIP-Seq_MESCs_Mouse1.98684555
17TP63_17297297_ChIP-ChIP_HaCaT_Human1.97929143
18MYC_19079543_ChIP-ChIP_MESCs_Mouse1.97857761
19* KDM2B_26808549_Chip-Seq_SIL-ALL_Human1.92180365
20* KDM2B_26808549_Chip-Seq_HPB-ALL_Human1.92108847
21ZFP281_18757296_ChIP-ChIP_E14_Mouse1.79321892
22ZFP281_27345836_Chip-Seq_ESCs_Mouse1.76613597
23* TBP_23326641_ChIP-Seq_C3H10T1-2_Mouse1.75577549
24NR1H3_23393188_ChIP-Seq_ATHEROSCLEROTIC-FOAM_Human1.75277750
25E2F1_21310950_ChIP-Seq_MCF-7_Human1.74483344
26KDM2B_26808549_Chip-Seq_SUP-B15_Human1.73615098
27ZIC3_20872845_ChIP-ChIP_MESCs_Mouse1.71073845
28FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse1.70462347
29* ELK3_25401928_ChIP-Seq_HUVEC_Human1.68293690
30KLF2_18264089_ChIP-ChIP_MESCs_Mouse1.67651663
31KLF5_18264089_ChIP-ChIP_MESCs_Mouse1.67651663
32KLF4_18264089_ChIP-ChIP_MESCs_Mouse1.67651663
33CIITA_25753668_ChIP-Seq_RAJI_Human1.67585836
34SMAD3_22036565_ChIP-Seq_ESCs_Mouse1.63989709
35STAT6_21828071_ChIP-Seq_BEAS2B_Human1.60930886
36POU5F1_18700969_ChIP-ChIP_MESCs_Mouse1.60796152
37SALL4_18804426_ChIP-ChIP_MESCs_Mouse1.58397719
38ESR1_15608294_ChIP-ChIP_MCF-7_Human1.55715551
39* UTX_26944678_Chip-Seq_JUKART_Human1.53082092
40KLF6_26769127_Chip-Seq_PDAC-Cell_line_Human1.52384803
41MAF_26560356_Chip-Seq_TH1_Human1.51707754
42TP63_19390658_ChIP-ChIP_HaCaT_Human1.51453870
43MYC_18358816_ChIP-ChIP_MESCs_Mouse1.45881150
44ZNF263_19887448_ChIP-Seq_K562_Human1.43707716
45* CREB1_23762244_ChIP-Seq_HIPPOCAMPUS_Rat1.42596561
46AR_21909140_ChIP-Seq_LNCAP_Human1.42408825
47* KDM2B_26808549_Chip-Seq_JURKAT_Human1.40893267
48* DMRT1_23473982_ChIP-Seq_TESTES_Mouse1.40183707
49CLOCK_20551151_ChIP-Seq_293T_Human1.37312903
50STAT3_1855785_ChIP-Seq_MESCs_Mouse1.36496393
51STAT3_22323479_ChIP-Seq_MACROPHAGE_Mouse1.35846963
52P300_27058665_Chip-Seq_ZR-75-30cells_Human1.34724447
53THRA_23701648_ChIP-Seq_CEREBELLUM_Mouse1.34646931
54EZH2_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse1.34589560
55NANOG_18700969_ChIP-ChIP_MESCs_Mouse1.32914508
56RARG_19884340_ChIP-ChIP_MEFs_Mouse1.31227367
57MYC_19030024_ChIP-ChIP_MESCs_Mouse1.30966281
58ASXL1_24218140_ChIP-Seq_BMDM_Mouse1.29712803
59HIF1A_21447827_ChIP-Seq_MCF-7_Human1.29312435
60XRN2_22483619_ChIP-Seq_HELA_Human1.28745289
61TCF3_18692474_ChIP-Seq_MEFs_Mouse1.28229294
62NELFA_20434984_ChIP-Seq_ESCs_Mouse1.27358554
63SALL1_21062744_ChIP-ChIP_HESCs_Human1.26813542
64CCND1_20090754_ChIP-ChIP_RETINA_Mouse1.26211250
65* NCOR1_26117541_ChIP-Seq_K562_Human1.25873001
66KLF4_26769127_Chip-Seq_PDAC-Cell_line_Human1.25175456
67PPARG_19300518_ChIP-PET_3T3-L1_Mouse1.24232280
68KLF4_18358816_ChIP-ChIP_MESCs_Mouse1.24022343
69TCF3_18467660_ChIP-ChIP_MESCs_Mouse1.23965961
70DACH1_20351289_ChIP-Seq_MDA-MB-231_Human1.23790889
71KDM5A_27292631_Chip-Seq_BREAST_Human1.23762002
72WT1_20215353_ChIP-ChIP_NEPHRON_PROGENITOR_Mouse1.23724965
73* NANOG_21062744_ChIP-ChIP_HESCs_Human1.22283533
74KLF4_18555785_ChIP-Seq_MESCs_Mouse1.22146670
75NANOG_18555785_ChIP-Seq_MESCs_Mouse1.20649559
76* TAL1_20887958_ChIP-Seq_HPC-7_Mouse1.20463775
77STAT6_20620947_ChIP-Seq_CD4_POS_T_Human1.20460114
78MYBL2_22936984_ChIP-ChIP_MESCs_Mouse1.20458726
79SOX2_18555785_ChIP-Seq_MESCs_Mouse1.20337320
80RACK7_27058665_Chip-Seq_MCF-7_Human1.20143630
81HSF1_23293686_ChIP-Seq_STHDH_STRIATAL_Mouse1.18900488
82RUNX2_24764292_ChIP-Seq_MC3T3_Mouse1.18541945
83CHD1_26751641_Chip-Seq_LNCaP_Human1.18255295
84TAL1_20566737_ChIP-Seq_PRIMARY_FETAL_LIVER_ERYTHROID_Mouse1.17821130
85SOX2_18358816_ChIP-ChIP_MESCs_Mouse1.15933761
86NANOG_18347094_ChIP-ChIP_MESCs_Mouse1.15740519
87* ATF3_27146783_Chip-Seq_COLON_Human1.14727285
88P68_20966046_ChIP-Seq_HELA_Human1.14136988
89CNOT3_19339689_ChIP-ChIP_MESCs_Mouse1.14024511
90CTCF_27219007_Chip-Seq_ERYTHROID_Human1.12819455
91TET1_21451524_ChIP-Seq_MESCs_Mouse1.12367238
92POU5F1_18555785_ChIP-Seq_MESCs_Mouse1.11900223
93TCF3_18692474_ChIP-Seq_MESCs_Mouse1.11173807
94UBF1/2_26484160_Chip-Seq_HMEC-DERIVED_Human1.11044979
95* PKCTHETA_26484144_Chip-Seq_BREAST_Human1.09382930
96* RUNX1_22412390_ChIP-Seq_EML_Mouse1.09231254
97VDR_24763502_ChIP-Seq_THP-1_Human1.08600603
98KDM2B_26808549_Chip-Seq_K562_Human1.07497762
99MYCN_18555785_ChIP-Seq_MESCs_Mouse1.06551211
100SREBP2_21459322_ChIP-Seq_LIVER_Mouse1.05824034
101GATA1_22383799_ChIP-Seq_G1ME_Mouse1.05707112
102* EP300_20729851_ChIP-Seq_FORBRAIN_MIDBRAIN_LIMB_HEART_Mouse1.05611503
103TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat1.05179833
104* LXR_22292898_ChIP-Seq_THP-1_Human1.04857912
105MYBL1_21750041_ChIP-ChIP_SPERMATOCYTES_Mouse1.04819665
106EGR1_20690147_ChIP-Seq_ERYTHROLEUKEMIA_Human1.04332204
107* FOXM1_26100407_CHIP-SEQ_Hek293_flp-in_Human1.02607129
108* CREM_20920259_ChIP-Seq_GC1-SPG_Mouse1.02323834
109NACC1_18358816_ChIP-ChIP_MESCs_Mouse1.02273420
110* CREB1_20920259_ChIP-Seq_GC1-SPG_Mouse1.02148849
111POU5F1_16518401_ChIP-PET_MESCs_Mouse1.01750689
112* MYB_26560356_Chip-Seq_TH1_Human1.01661749
113BRD4_27068464_Chip-Seq_AML-cells_Mouse1.00247353
114SA1_27219007_Chip-Seq_ERYTHROID_Human0.99865218
115* CREB1_26743006_Chip-Seq_LNCaP_Human0.99513266
116THAP11_20581084_ChIP-Seq_MESCs_Mouse0.99242020
117KLF4_19030024_ChIP-ChIP_MESCs_Mouse0.99163219
118* CREB1_26743006_Chip-Seq_LNCaP-abl_Human0.98711687
119ZFX_18555785_ChIP-Seq_MESCs_Mouse0.98605177
120TP53_22127205_ChIP-Seq_IMR90_Human0.98016171
121* MYB_26560356_Chip-Seq_TH2_Human0.97661017
122TFAP2C_20629094_ChIP-Seq_MCF-7_Human0.97167117
123MAF_26560356_Chip-Seq_TH2_Human0.97009181
124ELF3_26769127_Chip-Seq_PDAC-Cell_line_Human0.96569025
125TCFAP2C_20176728_ChIP-ChIP_TROPHOBLAST_STEM_CELLS_Mouse0.95844957
126E2A_27217539_Chip-Seq_RAMOS-Cell_line_Human0.94402265
127SMARCA4_20176728_ChIP-ChIP_TSCs_Mouse0.91777939

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0003705_abnormal_hypodermis_morpholog3.52500248
2MP0005076_abnormal_cell_differentiation3.31567293
3MP0010352_gastrointestinal_tract_polyps3.23730206
4MP0003111_abnormal_nucleus_morphology2.68191846
5MP0010094_abnormal_chromosome_stability2.35085130
6MP0010234_abnormal_vibrissa_follicle2.33305597
7MP0004957_abnormal_blastocyst_morpholog2.26195220
8MP0009278_abnormal_bone_marrow2.26179193
9MP0010307_abnormal_tumor_latency2.21759553
10MP0003077_abnormal_cell_cycle2.18917969
11MP0002009_preneoplasia2.17201375
12MP0004197_abnormal_fetal_growth/weight/2.07413304
13MP0001730_embryonic_growth_arrest2.02705537
14MP0005451_abnormal_body_composition2.01749458
15MP0003123_paternal_imprinting2.01296505
16MP0003566_abnormal_cell_adhesion1.99173576
17MP0008057_abnormal_DNA_replication1.96768618
18MP0003300_gastrointestinal_ulcer1.96129170
19MP0000350_abnormal_cell_proliferation1.95842053
20MP0000537_abnormal_urethra_morphology1.92967141
21MP0010030_abnormal_orbit_morphology1.90255757
22MP0002084_abnormal_developmental_patter1.89482680
23MP0001849_ear_inflammation1.83423674
24MP0005380_embryogenesis_phenotype1.83224787
25MP0001672_abnormal_embryogenesis/_devel1.83224787
26MP0002086_abnormal_extraembryonic_tissu1.78776567
27MP0003693_abnormal_embryo_hatching1.75554752
28MP0003984_embryonic_growth_retardation1.75154527
29MP0002085_abnormal_embryonic_tissue1.74956530
30MP0002088_abnormal_embryonic_growth/wei1.74822986
31MP0001348_abnormal_lacrimal_gland1.73515211
32MP0009053_abnormal_anal_canal1.73248310
33MP0000733_abnormal_muscle_development1.69617079
34MP0004808_abnormal_hematopoietic_stem1.66105867
35MP0001697_abnormal_embryo_size1.64588723
36MP0003567_abnormal_fetal_cardiomyocyte1.64367515
37MP0008007_abnormal_cellular_replicative1.63790707
38MP0002877_abnormal_melanocyte_morpholog1.62118884
39MP0000678_abnormal_parathyroid_gland1.57208559
40MP0005623_abnormal_meninges_morphology1.52290046
41MP0004858_abnormal_nervous_system1.50758839
42MP0000428_abnormal_craniofacial_morphol1.47006003
43MP0002080_prenatal_lethality1.44874891
44MP0005409_darkened_coat_color1.44804718
45MP0002796_impaired_skin_barrier1.43970500
46MP0003121_genomic_imprinting1.42253074
47MP0004185_abnormal_adipocyte_glucose1.40039994
48MP0002653_abnormal_ependyma_morphology1.38500261
49MP0003283_abnormal_digestive_organ1.37503487
50MP0003119_abnormal_digestive_system1.36017601
51MP0002396_abnormal_hematopoietic_system1.35733804
52MP0003303_peritoneal_inflammation1.35611459
53MP0005501_abnormal_skin_physiology1.32128354
54MP0003115_abnormal_respiratory_system1.32073726
55MP0003890_abnormal_embryonic-extraembry1.30107094
56MP0002249_abnormal_larynx_morphology1.27584121
57MP0002925_abnormal_cardiovascular_devel1.26321503
58MP0009703_decreased_birth_body1.26234353
59MP0008961_abnormal_basal_metabolism1.24347974
60MP0001915_intracranial_hemorrhage1.22191105
61MP0004947_skin_inflammation1.20937651
62MP0005023_abnormal_wound_healing1.19866926
63MP0000003_abnormal_adipose_tissue1.18172306
64MP0009672_abnormal_birth_weight1.14515382
65MP0000703_abnormal_thymus_morphology1.14351533
66MP0002697_abnormal_eye_size1.13492199
67MP0003935_abnormal_craniofacial_develop1.12749054
68MP0005375_adipose_tissue_phenotype1.12411937
69MP0006054_spinal_hemorrhage1.10833295
70MP0001661_extended_life_span1.10314664
71MP0000490_abnormal_crypts_of1.09861782
72MP0004233_abnormal_muscle_weight1.09221659
73MP0009333_abnormal_splenocyte_physiolog1.08421362
74MP0001346_abnormal_lacrimal_gland1.06694048
75MP0000569_abnormal_digit_pigmentation1.06534647
76MP0010630_abnormal_cardiac_muscle1.06389062
77MP0001293_anophthalmia1.06062209
78MP0005397_hematopoietic_system_phenotyp1.05809721
79MP0001545_abnormal_hematopoietic_system1.05809721
80MP0005058_abnormal_lysosome_morphology1.04971754
81MP0008260_abnormal_autophagy1.03990565
82MP0002092_abnormal_eye_morphology1.03639303
83MP0003385_abnormal_body_wall1.01828338
84MP0002060_abnormal_skin_morphology1.00074606
85MP0001873_stomach_inflammation0.99797276
86MP0003091_abnormal_cell_migration0.96406577
87MP0005257_abnormal_intraocular_pressure0.94564727
88MP0008932_abnormal_embryonic_tissue0.94333804
89MP0000313_abnormal_cell_death0.94097415
90MP0002111_abnormal_tail_morphology0.93846009
91MP0000266_abnormal_heart_morphology0.93456485
92MP0002019_abnormal_tumor_incidence0.92584557
93MP0003763_abnormal_thymus_physiology0.92166288
94MP0002006_tumorigenesis0.92039039
95MP0000432_abnormal_head_morphology0.91885269
96MP0001216_abnormal_epidermal_layer0.87657846
97MP0008770_decreased_survivor_rate0.86783241
98MP0001784_abnormal_fluid_regulation0.86482320
99MP0004264_abnormal_extraembryonic_tissu0.86246010
100MP0003453_abnormal_keratinocyte_physiol0.84207197
101MP0005367_renal/urinary_system_phenotyp0.83965220
102MP0000516_abnormal_urinary_system0.83965220
103MP0004272_abnormal_basement_membrane0.83344884
104MP0002166_altered_tumor_susceptibility0.82744673
105MP0009931_abnormal_skin_appearance0.82644508
106MP0000534_abnormal_ureter_morphology0.81679290
107MP0003861_abnormal_nervous_system0.81548757
108MP0003315_abnormal_perineum_morphology0.78423141
109MP0004782_abnormal_surfactant_physiolog0.78157908
110MP0003942_abnormal_urinary_system0.77960601
111MP0002932_abnormal_joint_morphology0.77546020
112MP0005384_cellular_phenotype0.77428617
113MP0000377_abnormal_hair_follicle0.76753101
114MP0002398_abnormal_bone_marrow0.76443920
115MP0008877_abnormal_DNA_methylation0.75304592
116MP0005666_abnormal_adipose_tissue0.75112243
117MP0000477_abnormal_intestine_morphology0.74152788
118MP0002098_abnormal_vibrissa_morphology0.73776613
119MP0008058_abnormal_DNA_repair0.73305062
120MP0003221_abnormal_cardiomyocyte_apopto0.73176117
121MP0008438_abnormal_cutaneous_collagen0.72498809
122MP0002282_abnormal_trachea_morphology0.71409081
123MP0000566_synostosis0.71221216
124MP0003937_abnormal_limbs/digits/tail_de0.70804754
125MP0002722_abnormal_immune_system0.70679272
126MP0005621_abnormal_cell_physiology0.70474158
127MP0002089_abnormal_postnatal_growth/wei0.69908398
128MP0004087_abnormal_muscle_fiber0.69818989
129MP0000858_altered_metastatic_potential0.69754275
130MP0003787_abnormal_imprinting0.69752912
131MP0001286_abnormal_eye_development0.69336752

Predicted human phenotypes

RankGene SetZ-score
1Ependymoma (HP:0002888)3.46241249
2Hyperacusis (HP:0010780)3.36722022
3Aplasia/Hypoplasia of the 4th metacarpal (HP:0010042)3.12125428
4Short 4th metacarpal (HP:0010044)3.12125428
5Astrocytoma (HP:0009592)2.91882967
6Abnormality of the astrocytes (HP:0100707)2.91882967
7Renal duplication (HP:0000075)2.87779305
8Cerebral aneurysm (HP:0004944)2.79188599
9Abnormality of the fingertips (HP:0001211)2.69221708
10Dysmetric saccades (HP:0000641)2.63887935
11Selective tooth agenesis (HP:0001592)2.62934077
12Shallow orbits (HP:0000586)2.61699298
13Increased nuchal translucency (HP:0010880)2.60647612
14Pseudobulbar signs (HP:0002200)2.52755825
15Abnormality of the 4th metacarpal (HP:0010012)2.50595989
16Disproportionate tall stature (HP:0001519)2.49999483
17Broad face (HP:0000283)2.48236295
18Long palpebral fissure (HP:0000637)2.45416047
19Renovascular hypertension (HP:0100817)2.45157734
20Elfin facies (HP:0004428)2.39450057
21Flat acetabular roof (HP:0003180)2.34246664
22Deviation of the thumb (HP:0009603)2.30205625
23Heterotopia (HP:0002282)2.27429867
24Distal lower limb amyotrophy (HP:0008944)2.26039551
25Macroorchidism (HP:0000053)2.23595835
26Proximal placement of thumb (HP:0009623)2.23592968
27Abnormality of the distal phalanx of the thumb (HP:0009617)2.22712279
28Medulloblastoma (HP:0002885)2.22642853
29Rectal prolapse (HP:0002035)2.21938435
30Gastrointestinal carcinoma (HP:0002672)2.21277531
31Malignant gastrointestinal tract tumors (HP:0006749)2.21277531
32Centrally nucleated skeletal muscle fibers (HP:0003687)2.19853665
33Progressive muscle weakness (HP:0003323)2.19132284
34Glioma (HP:0009733)2.18481455
35Deep palmar crease (HP:0006191)2.17739203
36Pointed chin (HP:0000307)2.17541554
37Ulnar bowing (HP:0003031)2.17473560
38Overriding aorta (HP:0002623)2.16701629
39Achilles tendon contracture (HP:0001771)2.16209829
40Basal cell carcinoma (HP:0002671)2.15651368
41Syringomyelia (HP:0003396)2.15079414
42Spinal cord lesions (HP:0100561)2.15079414
43Missing ribs (HP:0000921)2.14757511
44Long eyelashes (HP:0000527)2.14136200
45Bowel diverticulosis (HP:0005222)2.12630808
46Subacute progressive viral hepatitis (HP:0006572)2.12564903
47Ankle contracture (HP:0006466)2.08678177
48Neoplasm of striated muscle (HP:0009728)2.08307172
49Broad palm (HP:0001169)2.07898496
50Trigonocephaly (HP:0000243)2.05835806
51Increased density of long bones (HP:0006392)2.05535848
52Broad thumb (HP:0011304)2.03174287
53Neoplasm of the oral cavity (HP:0100649)2.00700237
54Protrusio acetabuli (HP:0003179)1.99864281
55High pitched voice (HP:0001620)1.99833155
56Volvulus (HP:0002580)1.97777322
57Supernumerary ribs (HP:0005815)1.97773341
58Trismus (HP:0000211)1.97582194
59Premature rupture of membranes (HP:0001788)1.96687201
60Skull defect (HP:0001362)1.96548987
61Skin tags (HP:0010609)1.96297288
62Insomnia (HP:0100785)1.95771526
63Increased connective tissue (HP:0009025)1.95501838
64Abnormality of the thoracic spine (HP:0100711)1.95150774
65Rhabdomyosarcoma (HP:0002859)1.94132175
66Enlarged penis (HP:0000040)1.93929585
67Obstructive sleep apnea (HP:0002870)1.93325672
68Patellar dislocation (HP:0002999)1.91181917
69Genu recurvatum (HP:0002816)1.91121622
70Mitral valve prolapse (HP:0001634)1.91104550
71Abnormality of the lower motor neuron (HP:0002366)1.90188738
72Progressive external ophthalmoplegia (HP:0000590)1.89913181
73Fibroma (HP:0010614)1.89843858
74Fibrous tissue neoplasm (HP:0012316)1.89524813
75Bladder diverticulum (HP:0000015)1.89380616
76High anterior hairline (HP:0009890)1.88872417
77Hereditary nonpolyposis colorectal carcinoma (HP:0006716)1.88162422
78Chromosomal breakage induced by crosslinking agents (HP:0003221)1.87397644
79Cellulitis (HP:0100658)1.86894804
80Germ cell neoplasia (HP:0100728)1.86048666
81Biliary tract neoplasm (HP:0100574)1.85758854
82Abnormal number of incisors (HP:0011064)1.85212870
83Flat cornea (HP:0007720)1.84921703
84Abnormality of the Achilles tendon (HP:0005109)1.84721468
85Hand muscle atrophy (HP:0009130)1.81336054
86Dislocated radial head (HP:0003083)1.81319633
87Broad distal phalanx of finger (HP:0009836)1.81205167
88Abnormality of the distal phalanges of the toes (HP:0010182)1.79959062
89Colon cancer (HP:0003003)1.79738436
90Sandal gap (HP:0001852)1.79724271
91Upper limb amyotrophy (HP:0009129)1.79652750
92Distal upper limb amyotrophy (HP:0007149)1.79652750
93Abnormality of the salivary glands (HP:0010286)1.77353256
94Prominent nose (HP:0000448)1.77205963
95Abnormality of the diencephalon (HP:0010662)1.77092301
96Obsessive-compulsive behavior (HP:0000722)1.76560118
97Arnold-Chiari malformation (HP:0002308)1.76162374
98Septate vagina (HP:0001153)1.75814042
99Sparse lateral eyebrow (HP:0005338)1.75673726
100Bicuspid aortic valve (HP:0001647)1.75328790
101Adenoma sebaceum (HP:0009720)1.75311895
102Angiofibromas (HP:0010615)1.75311895
103Vertebral compression fractures (HP:0002953)1.73892204
104Neonatal hypoglycemia (HP:0001998)1.73560437
105Biconcave vertebral bodies (HP:0004586)1.73421186
106Deviation of the hallux (HP:0010051)1.73263612
107Turricephaly (HP:0000262)1.72861806
108Ankyloglossia (HP:0010296)1.72594899
109Hallux valgus (HP:0001822)1.72525542
110Deep philtrum (HP:0002002)1.72112337
111Rib fusion (HP:0000902)1.70848526
112Large earlobe (HP:0009748)1.70768707
113Advanced eruption of teeth (HP:0006288)1.69532596
114Reticulocytosis (HP:0001923)1.68700956
115Cutis marmorata (HP:0000965)1.68441400
116Short phalanx of the thumb (HP:0009660)1.68432800
117Thin ribs (HP:0000883)1.68192153
118Relative macrocephaly (HP:0004482)1.68011977
119Truncus arteriosus (HP:0001660)1.67555184
120Bowel incontinence (HP:0002607)1.67234542
121Abnormality of oral frenula (HP:0000190)1.66801702
122Broad phalanges of the hand (HP:0009768)1.66655334
123Lymphangioma (HP:0100764)1.66449483
124Leiomyosarcoma (HP:0100243)1.66159904
125Uterine leiomyosarcoma (HP:0002891)1.66159904
126Flared metaphyses (HP:0003015)1.66109458
127Termporal pattern (HP:0011008)1.66072231
128Insidious onset (HP:0003587)1.66072231
129Supernumerary bones of the axial skeleton (HP:0009144)1.65376221
130Preauricular skin tag (HP:0000384)1.65333899
131Abnormality of the radial head (HP:0003995)1.64666220
132Aneurysm (HP:0002617)1.64574132
133Esophageal atresia (HP:0002032)1.64555869
134Dilatation of the ascending aorta (HP:0005111)1.64253201
135Lower limb amyotrophy (HP:0007210)1.63234947
136Chromsome breakage (HP:0040012)1.62992331
137Abnormality of the calcaneus (HP:0008364)1.62859684
138Asymmetry of the thorax (HP:0001555)1.61875494
139Urethral obstruction (HP:0000796)1.61453139
140Metaphyseal cupping (HP:0003021)1.61373046
141Vertebral arch anomaly (HP:0008438)1.60899604
142Colitis (HP:0002583)1.60478918
143Annular pancreas (HP:0001734)1.60343037
144Back pain (HP:0003418)1.60233772
145Narrow palate (HP:0000189)1.58914959
146Short 1st metacarpal (HP:0010034)1.58908214
147Aplasia/Hypoplasia of the 1st metacarpal (HP:0010026)1.58908214
148Transitional cell carcinoma of the bladder (HP:0006740)1.58777496
149Cafe-au-lait spot (HP:0000957)1.58458927
150Persistence of primary teeth (HP:0006335)1.58315815
151Abnormality of the phalanges of the hallux (HP:0010057)1.58035067
152Short humerus (HP:0005792)1.57466543
153Mitral regurgitation (HP:0001653)1.57017077
154Overlapping toe (HP:0001845)1.56792912
155Abnormal large intestine physiology (HP:0012700)1.55425973
156Viral hepatitis (HP:0006562)1.54991829
157Thoracic kyphosis (HP:0002942)1.52631425
158Parkinsonism with favorable response to dopaminergic medication (HP:0002548)1.52412848
159Orthostatic hypotension (HP:0001278)1.50868634
160Abnormality of reticulocytes (HP:0004312)1.50688487
161Polygenic inheritance (HP:0010982)1.50141801
162Spina bifida occulta (HP:0003298)1.49324256
163Thin bony cortex (HP:0002753)1.48412764

Predicted kinase interactions (KEA)

RankGene SetZ-score
1CDK124.40191544
2SMG14.35813691
3EEF2K4.12893328
4PKN23.75230766
5TRIB33.69474689
6MAP3K103.61245704
7PRPF4B3.10895238
8CDC72.59736640
9NEK22.04190545
10IRAK31.97386718
11ALK1.84044090
12TTN1.83808174
13BRD41.82081899
14ICK1.81746155
15PTK61.78439628
16NEK11.77514813
17PDGFRA1.74653006
18RPS6KB21.71638626
19RIPK11.64310138
20STK101.60181022
21CDK41.53367776
22LATS11.49453964
23CDK61.48810362
24MAP3K131.42385350
25MTOR1.40966940
26BMX1.37940465
27PAK41.37447340
28NME21.34283432
29SCYL21.32524954
30TYRO31.29204972
31LRRK21.27413959
32PASK1.27070856
33TTK1.17451983
34MAP4K11.15597691
35MAP3K81.14025597
36SIK11.10641322
37GRK61.10542231
38CAMK1D1.05206808
39CDK71.04649905
40EPHA21.00821496
41MAP3K90.98658073
42MST1R0.96556246
43CHEK10.96378887
44SIK20.95406436
45ATR0.93192650
46MKNK10.92942839
47PAK20.92034452
48STK40.91804132
49BUB10.91192494
50CAMK1G0.90639178
51MAP3K140.90402939
52TESK20.90318894
53STK30.89553581
54TAOK20.88253024
55PIM10.87653761
56TSSK60.86876898
57FGFR10.86724212
58MAPK110.85552100
59MKNK20.85477271
60FGFR30.85001456
61MAP2K20.81670350
62CDK20.79618654
63PDGFRB0.77561023
64DDR20.77290060
65BRAF0.76470687
66FLT30.76198189
67DMPK0.75618215
68ERN10.72114912
69ATM0.71722353
70AURKB0.70930061
71WEE10.70688396
72CDK90.69329944
73TGFBR10.66879161
74PRKD30.65894115
75TLK10.65325429
76FGFR20.64629202
77PLK10.63341126
78AURKA0.62309555
79RPS6KA40.62059570
80LATS20.61629414
81AKT20.61067174
82DYRK1B0.60611022
83CLK10.60550430
84MARK20.59886519
85ARAF0.59641772
86MAP3K70.59066003
87FGFR40.56562264
88TAOK10.56403751
89CDK80.53970252
90CSNK1D0.53643395
91MAP3K10.53530793
92RPS6KA20.53206836
93PTK20.52974640
94PDPK10.52884128
95CHEK20.52538920
96HIPK20.52473851
97KDR0.52412638
98CDK10.51927028
99TAF10.51137344
100CDC42BPA0.49321814
101RPS6KL10.49209231
102RPS6KC10.49209231
103RPS6KA10.48584126
104MELK0.48347409
105SRPK10.47667943
106JAK30.46980542
107IRAK40.46674545
108TESK10.46428256
109ILK0.46096537
110MAPK140.45783583
111CHUK0.45753619
112PRKDC0.45399963
113AKT10.45103534
114KSR10.44186928
115RET0.44102356
116SGK30.43717727
117NTRK10.43245951
118IRAK20.43069280
119MAPK10.40655617
120MAP2K30.40163643
121CSNK1E0.39975986
122RPS6KA60.39702539
123CSK0.39114092
124RIPK40.37869158
125KSR20.37537077
126ITK0.37468433
127PRKD20.36979425
128RAF10.34989138
129MET0.32968505
130CDK11A0.30928901
131BRSK10.30814271
132BTK0.30048497
133EPHB10.29334218
134MAPK100.29124073

Predicted pathways (KEGG)

RankGene SetZ-score
1mRNA surveillance pathway_Homo sapiens_hsa030152.12384554
2DNA replication_Homo sapiens_hsa030302.07570607
3Spliceosome_Homo sapiens_hsa030401.95533200
4Chronic myeloid leukemia_Homo sapiens_hsa052201.93736745
5RNA transport_Homo sapiens_hsa030131.90824451
6Butirosin and neomycin biosynthesis_Homo sapiens_hsa005241.87749456
7Cell cycle_Homo sapiens_hsa041101.81447657
8Mismatch repair_Homo sapiens_hsa034301.80209488
9Notch signaling pathway_Homo sapiens_hsa043301.73642988
10One carbon pool by folate_Homo sapiens_hsa006701.72313369
11MicroRNAs in cancer_Homo sapiens_hsa052061.70568665
12mTOR signaling pathway_Homo sapiens_hsa041501.70252506
13Lysine degradation_Homo sapiens_hsa003101.69410553
14Adherens junction_Homo sapiens_hsa045201.62890081
15Pentose phosphate pathway_Homo sapiens_hsa000301.58408559
16Small cell lung cancer_Homo sapiens_hsa052221.55161277
17Basal cell carcinoma_Homo sapiens_hsa052171.49629167
18Viral carcinogenesis_Homo sapiens_hsa052031.47870945
19Colorectal cancer_Homo sapiens_hsa052101.41587791
20Central carbon metabolism in cancer_Homo sapiens_hsa052301.41290773
21Hippo signaling pathway_Homo sapiens_hsa043901.40742670
22Endometrial cancer_Homo sapiens_hsa052131.40653474
23Proteoglycans in cancer_Homo sapiens_hsa052051.39013754
24Bacterial invasion of epithelial cells_Homo sapiens_hsa051001.36561021
25HTLV-I infection_Homo sapiens_hsa051661.36265516
26Non-small cell lung cancer_Homo sapiens_hsa052231.36189713
27Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa045501.36069051
28Thyroid hormone signaling pathway_Homo sapiens_hsa049191.32572629
29Base excision repair_Homo sapiens_hsa034101.29312335
30Viral myocarditis_Homo sapiens_hsa054161.26378392
31Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa009701.25902598
32Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030081.25238224
33Transcriptional misregulation in cancer_Homo sapiens_hsa052021.21768629
34Systemic lupus erythematosus_Homo sapiens_hsa053221.20448049
35Acute myeloid leukemia_Homo sapiens_hsa052211.20353979
36Other glycan degradation_Homo sapiens_hsa005111.17712399
37Focal adhesion_Homo sapiens_hsa045101.17652372
38Thyroid cancer_Homo sapiens_hsa052161.16916990
39Bladder cancer_Homo sapiens_hsa052191.16150610
40Progesterone-mediated oocyte maturation_Homo sapiens_hsa049141.15333813
41Ubiquitin mediated proteolysis_Homo sapiens_hsa041201.14723869
42p53 signaling pathway_Homo sapiens_hsa041151.12199997
43Prion diseases_Homo sapiens_hsa050201.08687697
44Neurotrophin signaling pathway_Homo sapiens_hsa047221.08382015
45Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate_Homo sapiens_hsa005321.08211230
46Glioma_Homo sapiens_hsa052141.07607505
47AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa049331.06424572
48Pancreatic cancer_Homo sapiens_hsa052121.05146846
49B cell receptor signaling pathway_Homo sapiens_hsa046621.05133421
50Fc gamma R-mediated phagocytosis_Homo sapiens_hsa046661.02394312
51Antigen processing and presentation_Homo sapiens_hsa046121.00787303
52Prostate cancer_Homo sapiens_hsa052150.99000786
53Leukocyte transendothelial migration_Homo sapiens_hsa046700.98025692
54Hedgehog signaling pathway_Homo sapiens_hsa043400.97612695
55VEGF signaling pathway_Homo sapiens_hsa043700.96358542
56Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa049610.95982026
57Citrate cycle (TCA cycle)_Homo sapiens_hsa000200.95397602
58TGF-beta signaling pathway_Homo sapiens_hsa043500.94440203
59Fc epsilon RI signaling pathway_Homo sapiens_hsa046640.93665889
60T cell receptor signaling pathway_Homo sapiens_hsa046600.93645482
61Dorso-ventral axis formation_Homo sapiens_hsa043200.91863430
62Pathways in cancer_Homo sapiens_hsa052000.91118959
63HIF-1 signaling pathway_Homo sapiens_hsa040660.90815984
64Fructose and mannose metabolism_Homo sapiens_hsa000510.90036158
65Renal cell carcinoma_Homo sapiens_hsa052110.89576742
66Herpes simplex infection_Homo sapiens_hsa051680.87112433
67Tight junction_Homo sapiens_hsa045300.87053192
68Oocyte meiosis_Homo sapiens_hsa041140.87019566
69Hepatitis B_Homo sapiens_hsa051610.86390832
70Longevity regulating pathway - mammal_Homo sapiens_hsa042110.85722545
71Insulin resistance_Homo sapiens_hsa049310.84296424
72Regulation of actin cytoskeleton_Homo sapiens_hsa048100.84240849
73Cyanoamino acid metabolism_Homo sapiens_hsa004600.83541931
74Nucleotide excision repair_Homo sapiens_hsa034200.83417426
75Wnt signaling pathway_Homo sapiens_hsa043100.82101977
76Choline metabolism in cancer_Homo sapiens_hsa052310.80578875
77Toxoplasmosis_Homo sapiens_hsa051450.79683456
78Apoptosis_Homo sapiens_hsa042100.79134354
79Estrogen signaling pathway_Homo sapiens_hsa049150.78418093
80Longevity regulating pathway - multiple species_Homo sapiens_hsa042130.77928522
81FoxO signaling pathway_Homo sapiens_hsa040680.77871137
82Hepatitis C_Homo sapiens_hsa051600.76456010
83AMPK signaling pathway_Homo sapiens_hsa041520.75215371
84ECM-receptor interaction_Homo sapiens_hsa045120.74910965
85Primary immunodeficiency_Homo sapiens_hsa053400.74400433
86Alcoholism_Homo sapiens_hsa050340.73569631
87Arrhythmogenic right ventricular cardiomyopathy (ARVC)_Homo sapiens_hsa054120.73555062
88Carbon metabolism_Homo sapiens_hsa012000.73554441
89Insulin signaling pathway_Homo sapiens_hsa049100.73487672
90RNA degradation_Homo sapiens_hsa030180.72983428
91Inositol phosphate metabolism_Homo sapiens_hsa005620.72712423
92Prolactin signaling pathway_Homo sapiens_hsa049170.69234082
93Platelet activation_Homo sapiens_hsa046110.69002535
94Epstein-Barr virus infection_Homo sapiens_hsa051690.67900042
95Phospholipase D signaling pathway_Homo sapiens_hsa040720.67091162
96GnRH signaling pathway_Homo sapiens_hsa049120.66012709
97Galactose metabolism_Homo sapiens_hsa000520.65241095
98Amoebiasis_Homo sapiens_hsa051460.64428060
992-Oxocarboxylic acid metabolism_Homo sapiens_hsa012100.62627304
100Rap1 signaling pathway_Homo sapiens_hsa040150.62543506
101Osteoclast differentiation_Homo sapiens_hsa043800.61589842
102Adipocytokine signaling pathway_Homo sapiens_hsa049200.60840424
103NF-kappa B signaling pathway_Homo sapiens_hsa040640.59284001
104Type II diabetes mellitus_Homo sapiens_hsa049300.59105444
105Sphingolipid signaling pathway_Homo sapiens_hsa040710.59081570
106ErbB signaling pathway_Homo sapiens_hsa040120.59045701
107Toll-like receptor signaling pathway_Homo sapiens_hsa046200.58951582
108Fanconi anemia pathway_Homo sapiens_hsa034600.58925105
109Shigellosis_Homo sapiens_hsa051310.58844260
110Measles_Homo sapiens_hsa051620.57769816
111Glucagon signaling pathway_Homo sapiens_hsa049220.57449161
112Melanoma_Homo sapiens_hsa052180.55559880
113Non-homologous end-joining_Homo sapiens_hsa034500.55372783
114Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004000.54900011
115Pathogenic Escherichia coli infection_Homo sapiens_hsa051300.53472030
116PI3K-Akt signaling pathway_Homo sapiens_hsa041510.52834434
117Homologous recombination_Homo sapiens_hsa034400.52555977
118Long-term potentiation_Homo sapiens_hsa047200.51547304
119Dilated cardiomyopathy_Homo sapiens_hsa054140.51460048
120Influenza A_Homo sapiens_hsa051640.50564779
121Biosynthesis of amino acids_Homo sapiens_hsa012300.50254079
122Protein processing in endoplasmic reticulum_Homo sapiens_hsa041410.49791251
123Phosphatidylinositol signaling system_Homo sapiens_hsa040700.49716747
124TNF signaling pathway_Homo sapiens_hsa046680.49546232
125Melanogenesis_Homo sapiens_hsa049160.49110535

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