HNRNPLL

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: HNRNPLL is a master regulator of activation-induced alternative splicing in T cells. In particular, it alters splicing of CD45 (PTPRC; MIM 151460), a tyrosine phosphatase essential for T-cell development and activation (Oberdoerffer et al., 2008 [PubMed 18669861]). NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1phenylpropanoid metabolic process (GO:0009698)7.92794756
2nuclear pore complex assembly (GO:0051292)4.61151510
3cellular glucuronidation (GO:0052695)4.43314068
4regulation of single stranded viral RNA replication via double stranded DNA intermediate (GO:00450914.25097721
5nuclear pore organization (GO:0006999)4.17277710
6regulation of stem cell maintenance (GO:2000036)4.16766350
7regulation of protein kinase C signaling (GO:0090036)4.12928965
8positive regulation of G2/M transition of mitotic cell cycle (GO:0010971)4.07640060
9positive regulation of cell cycle G2/M phase transition (GO:1902751)4.07640060
10pore complex assembly (GO:0046931)3.99727511
11response to muramyl dipeptide (GO:0032495)3.87518836
12otic vesicle formation (GO:0030916)3.86389505
13glucuronate metabolic process (GO:0019585)3.84615654
14uronic acid metabolic process (GO:0006063)3.84615654
15positive regulation of protein kinase C signaling (GO:0090037)3.82176944
16interkinetic nuclear migration (GO:0022027)3.80022620
17presynaptic membrane assembly (GO:0097105)3.79293738
18limb bud formation (GO:0060174)3.78978187
19flavonoid metabolic process (GO:0009812)3.78316107
20anterior/posterior axis specification, embryo (GO:0008595)3.65907168
21regulation of pigment cell differentiation (GO:0050932)3.58312598
22mitotic sister chromatid cohesion (GO:0007064)3.57420181
23neural tube formation (GO:0001841)3.56344643
24negative regulation of fatty acid metabolic process (GO:0045922)3.51606771
25intraciliary transport (GO:0042073)3.51212397
26RNA stabilization (GO:0043489)3.51093594
27mRNA stabilization (GO:0048255)3.51093594
28heterochromatin organization (GO:0070828)3.49888493
29DNA double-strand break processing (GO:0000729)3.41532144
30mitochondrial outer membrane permeabilization involved in programmed cell death (GO:1902686)3.35707206
31positive regulation of mitochondrial membrane permeability involved in apoptotic process (GO:19021103.35707206
32positive regulation of male gonad development (GO:2000020)3.32257271
33DNA integration (GO:0015074)3.31996498
34regulation of meiosis I (GO:0060631)3.25515193
35pre-miRNA processing (GO:0031054)3.20609868
36regulation of male gonad development (GO:2000018)3.19494772
37DNA unwinding involved in DNA replication (GO:0006268)3.14409210
383-UTR-mediated mRNA stabilization (GO:0070935)3.12628085
39negative regulation of keratinocyte proliferation (GO:0010839)3.08015250
40CENP-A containing nucleosome assembly (GO:0034080)3.05854046
41chromatin remodeling at centromere (GO:0031055)3.05430874
42establishment or maintenance of epithelial cell apical/basal polarity (GO:0045197)3.03931923
43response to folic acid (GO:0051593)3.03916667
44protein neddylation (GO:0045116)3.03257274
45resolution of meiotic recombination intermediates (GO:0000712)3.01290851
46modulation by symbiont of host cellular process (GO:0044068)3.00574542
47oligosaccharide catabolic process (GO:0009313)3.00364541
48kinetochore assembly (GO:0051382)2.96506563
49microtubule depolymerization (GO:0007019)2.95120304
50presynaptic membrane organization (GO:0097090)2.94166559
51mesenchymal to epithelial transition involved in metanephros morphogenesis (GO:0003337)2.94149130
52regulation of development, heterochronic (GO:0040034)2.94086793
53negative regulation of DNA recombination (GO:0045910)2.93212537
54retinal ganglion cell axon guidance (GO:0031290)2.92776321
55sister chromatid cohesion (GO:0007062)2.92083405
56negative regulation of mRNA splicing, via spliceosome (GO:0048025)2.91721716
57histone H2A acetylation (GO:0043968)2.88003411
58retinal rod cell development (GO:0046548)2.83802211
59protein localization to kinetochore (GO:0034501)2.82187581
60peptidyl-arginine omega-N-methylation (GO:0035247)2.82068674
61nonmotile primary cilium assembly (GO:0035058)2.81179491
62neuron cell-cell adhesion (GO:0007158)2.80333011
63negative regulation of mitotic metaphase/anaphase transition (GO:0045841)2.80005893
64negative regulation of metaphase/anaphase transition of cell cycle (GO:1902100)2.80005893
65negative regulation of mitotic sister chromatid segregation (GO:0033048)2.80005893
66negative regulation of mitotic sister chromatid separation (GO:2000816)2.80005893
67negative regulation of sister chromatid segregation (GO:0033046)2.80005893
68protein localization to cilium (GO:0061512)2.79501616
69regulation of DNA endoreduplication (GO:0032875)2.78916112
70response to peptidoglycan (GO:0032494)2.78499129
71negative regulation of mRNA processing (GO:0050686)2.76917624
72developmental pigmentation (GO:0048066)2.75297524
73neuronal stem cell maintenance (GO:0097150)2.75207731
74mitotic metaphase plate congression (GO:0007080)2.72578328
75establishment of integrated proviral latency (GO:0075713)2.70680108
76regulation of double-strand break repair via homologous recombination (GO:0010569)2.70669269
77negative regulation of chromosome segregation (GO:0051985)2.69670313
78dosage compensation (GO:0007549)2.69042408
79negative regulation of RNA splicing (GO:0033119)2.69017888
80mesenchymal to epithelial transition (GO:0060231)2.67588343
81cilium morphogenesis (GO:0060271)2.67547294
82DNA ligation (GO:0006266)2.67129720
83DNA replication initiation (GO:0006270)2.66349309
84olfactory bulb development (GO:0021772)2.66275292
85mitotic spindle checkpoint (GO:0071174)2.65446953
86melanin metabolic process (GO:0006582)2.65109275
87positive regulation of mitochondrial fission (GO:0090141)2.64168417
88mitotic spindle assembly checkpoint (GO:0007094)2.61966261
89regulation of sister chromatid segregation (GO:0033045)2.61800087
90regulation of mitotic sister chromatid separation (GO:0010965)2.61800087
91regulation of mitotic sister chromatid segregation (GO:0033047)2.61800087
92regulation of integrin activation (GO:0033623)2.61122246
93metaphase plate congression (GO:0051310)2.60890221
94omega-hydroxylase P450 pathway (GO:0097267)2.60664019
95protein prenylation (GO:0018342)2.60321928
96prenylation (GO:0097354)2.60321928
97paraxial mesoderm development (GO:0048339)2.60297221
98regulation of mitotic cell cycle spindle assembly checkpoint (GO:0090266)2.59814324
99regulation of mitotic spindle checkpoint (GO:1903504)2.59814324
100cerebellar Purkinje cell layer development (GO:0021680)2.58228264
101spindle checkpoint (GO:0031577)2.58099134
102spindle assembly checkpoint (GO:0071173)2.57550048
103regulation of mitotic metaphase/anaphase transition (GO:0030071)2.57451031
104regulation of metaphase/anaphase transition of cell cycle (GO:1902099)2.57451031
105peptidyl-arginine methylation (GO:0018216)2.57092465
106peptidyl-arginine N-methylation (GO:0035246)2.57092465
107eyelid development in camera-type eye (GO:0061029)2.56322272
108pyrimidine nucleobase catabolic process (GO:0006208)2.56271273
109regulation of timing of cell differentiation (GO:0048505)2.56193912
110protein localization to chromosome, centromeric region (GO:0071459)2.54185568
111cullin deneddylation (GO:0010388)2.53977087
112histone exchange (GO:0043486)2.53898178
113regulation of mRNA stability (GO:0043488)2.53447528
114sister chromatid segregation (GO:0000819)2.52802437
115regulation of double-strand break repair (GO:2000779)2.51930222
116regulation of keratinocyte proliferation (GO:0010837)2.51587970
117forebrain neuron differentiation (GO:0021879)2.51306870
118maintenance of fidelity involved in DNA-dependent DNA replication (GO:0045005)2.51118995
119dorsal/ventral axis specification (GO:0009950)2.51101493
120establishment of nucleus localization (GO:0040023)2.50907203
121synapsis (GO:0007129)2.50877348
122regulation of chromosome segregation (GO:0051983)2.49494135
123modulation by virus of host process (GO:0019054)2.49317974
124regulation of centriole replication (GO:0046599)2.48685334
125lung-associated mesenchyme development (GO:0060484)2.46354597
126protein K11-linked ubiquitination (GO:0070979)2.46117553
127regulation of cell proliferation involved in heart morphogenesis (GO:2000136)2.45209456
128attachment of spindle microtubules to kinetochore (GO:0008608)2.43993947
129melanin biosynthetic process (GO:0042438)2.43700277
130DNA strand renaturation (GO:0000733)2.42989724
131DNA replication-independent nucleosome organization (GO:0034724)2.42627090
132DNA replication-independent nucleosome assembly (GO:0006336)2.42627090
133protein deneddylation (GO:0000338)2.41772007
134meiotic chromosome segregation (GO:0045132)2.41158329
135negative regulation of mitosis (GO:0045839)2.40860819
136cranial suture morphogenesis (GO:0060363)2.40637562
137neuron projection extension involved in neuron projection guidance (GO:1902284)2.39535359
138axon extension involved in axon guidance (GO:0048846)2.39535359
139axonal fasciculation (GO:0007413)2.38086854
140Notch signaling involved in heart development (GO:0061314)2.38026770
141mitotic nuclear envelope disassembly (GO:0007077)2.37984414
142retinoic acid metabolic process (GO:0042573)2.37322739
143regulation of sister chromatid cohesion (GO:0007063)2.36938369
144positive regulation of dendritic spine morphogenesis (GO:0061003)2.36584750
145double-strand break repair via nonhomologous end joining (GO:0006303)2.36174879
146non-recombinational repair (GO:0000726)2.36174879
147microtubule anchoring (GO:0034453)2.36098234
148regulation of RNA stability (GO:0043487)2.34695217
149negative regulation of mRNA metabolic process (GO:1903312)2.34693525
150digestive tract morphogenesis (GO:0048546)2.34665720
151gastrulation with mouth forming second (GO:0001702)2.33683971
152DNA geometric change (GO:0032392)2.33030522
153ganglion development (GO:0061548)2.32736379
154regulation of histone H3-K27 methylation (GO:0061085)2.31939172
155regulation of T-helper 1 cell differentiation (GO:0045625)2.31722844
156generation of neurons (GO:0048699)2.31716987
157notochord development (GO:0030903)2.31490947
158negative regulation of DNA-dependent DNA replication (GO:2000104)2.31265022
159regulation of developmental pigmentation (GO:0048070)2.29868219
160positive regulation of protein homooligomerization (GO:0032464)2.29833993
161regulation of transcription involved in G1/S transition of mitotic cell cycle (GO:0000083)2.29691809
162mammary gland epithelial cell differentiation (GO:0060644)2.29584751
163prostate gland growth (GO:0060736)2.29544488
164somite development (GO:0061053)2.29243174
165retinal cone cell development (GO:0046549)2.29202790
166DNA duplex unwinding (GO:0032508)2.28721113
167replication fork processing (GO:0031297)2.28580065
168nephron tubule formation (GO:0072079)2.28341644
169negative regulation of oligodendrocyte differentiation (GO:0048715)2.28296969
170lens morphogenesis in camera-type eye (GO:0002089)2.27618967
171cell fate commitment involved in formation of primary germ layer (GO:0060795)2.27605647
172translesion synthesis (GO:0019985)2.27447206
173ectodermal placode formation (GO:0060788)2.27047019
174postreplication repair (GO:0006301)2.26811582
175pituitary gland development (GO:0021983)2.26629671
176positive regulation of mitotic sister chromatid separation (GO:1901970)2.26594479
177positive regulation of mitotic metaphase/anaphase transition (GO:0045842)2.26594479
178positive regulation of metaphase/anaphase transition of cell cycle (GO:1902101)2.26594479
179nuclear envelope disassembly (GO:0051081)2.26590879
180membrane disassembly (GO:0030397)2.26590879
181positive regulation of developmental pigmentation (GO:0048087)2.25770411
182somatic hypermutation of immunoglobulin genes (GO:0016446)2.25655286
183somatic diversification of immune receptors via somatic mutation (GO:0002566)2.25655286
184regulation of centrosome duplication (GO:0010824)2.25543050
185negative regulation of calcium ion-dependent exocytosis (GO:0045955)2.24169433
186negative regulation of steroid metabolic process (GO:0045939)2.23793265
187chromatin assembly (GO:0031497)2.21191651
188cell volume homeostasis (GO:0006884)2.21161563
189kinetochore organization (GO:0051383)2.20417907
190apoptotic process involved in morphogenesis (GO:0060561)2.18166037
191proximal/distal pattern formation (GO:0009954)2.17803928
192epithelial cell fate commitment (GO:0072148)2.17801393

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1FOXM1_23109430_ChIP-Seq_U2OS_Human5.79169750
2EGR1_19374776_ChIP-ChIP_THP-1_Human4.51336501
3E2F4_17652178_ChIP-ChIP_JURKAT_Human4.27693927
4NUCKS1_24931609_ChIP-Seq_HEPATOCYTES_Mouse3.69306609
5HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse3.45239223
6SOX9_22984422_ChIP-ChIP_TESTIS_Rat3.15210798
7POU3F2_20337985_ChIP-ChIP_501MEL_Human2.95967679
8IGF1R_20145208_ChIP-Seq_DFB_Human2.86458837
9TP63_17297297_ChIP-ChIP_HaCaT_Human2.73200663
10TAF15_26573619_Chip-Seq_HEK293_Human2.72570020
11FOXM1_25889361_ChIP-Seq_OE33_AND_U2OS_Human2.57445604
12FUS_26573619_Chip-Seq_HEK293_Human2.55892183
13KLF2_18264089_ChIP-ChIP_MESCs_Mouse2.50033173
14KLF5_18264089_ChIP-ChIP_MESCs_Mouse2.50033173
15KLF4_18264089_ChIP-ChIP_MESCs_Mouse2.50033173
16ELK1_19687146_ChIP-ChIP_HELA_Human2.44359082
17EWS_26573619_Chip-Seq_HEK293_Human2.42857790
18CEBPD_23245923_ChIP-Seq_MEFs_Mouse2.38517606
19SALL1_21062744_ChIP-ChIP_HESCs_Human2.36475430
20ZNF274_21170338_ChIP-Seq_K562_Hela2.31647518
21GBX2_23144817_ChIP-Seq_PC3_Human2.26847680
22TRIM28_21343339_ChIP-Seq_HEK293_Human2.23572526
23ZFP57_27257070_Chip-Seq_ESCs_Mouse2.21927305
24KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human2.19528239
25VDR_21846776_ChIP-Seq_THP-1_Human2.17191738
26PKCTHETA_26484144_Chip-Seq_BREAST_Human2.12353772
27E2F1_21310950_ChIP-Seq_MCF-7_Human2.03658857
28PPARG_23326641_ChIP-Seq_C3H10T1-2_Mouse2.03318420
29E2F7_22180533_ChIP-Seq_HELA_Human10.6493739
30FLI1_27457419_Chip-Seq_LIVER_Mouse1.98348157
31WT1_19549856_ChIP-ChIP_CCG9911_Human1.94692093
32AR_21909140_ChIP-Seq_LNCAP_Human1.92244003
33KDM5B_21448134_ChIP-Seq_MESCs_Mouse1.91279943
34MYC_18555785_ChIP-Seq_MESCs_Mouse1.91270390
35GABP_17652178_ChIP-ChIP_JURKAT_Human1.89977091
36P300_19829295_ChIP-Seq_ESCs_Human1.87854785
37MYCN_21190229_ChIP-Seq_SHEP-21N_Human1.83170372
38ZFP281_18358816_ChIP-ChIP_MESCs_Mouse1.81778073
39MYB_21317192_ChIP-Seq_ERMYB_Mouse1.79847809
40HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human1.72596391
41TP63_19390658_ChIP-ChIP_HaCaT_Human1.70267202
42MYC_22102868_ChIP-Seq_BL_Human1.68394761
43CDX2_20551321_ChIP-Seq_CACO-2_Human1.67100780
44STAT6_20620947_ChIP-Seq_CD4_POS_T_Human1.65141677
45PCGF2_27294783_Chip-Seq_ESCs_Mouse1.63818042
46VDR_24763502_ChIP-Seq_THP-1_Human1.62680954
47PADI4_21655091_ChIP-ChIP_MCF-7_Human1.60458210
48CHD1_19587682_ChIP-ChIP_MESCs_Mouse1.60362030
49PRDM5_23873026_ChIP-Seq_MEFs_Mouse1.59720379
50SMARCA4_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.59307086
51EST1_17652178_ChIP-ChIP_JURKAT_Human1.59040465
52CTBP2_25329375_ChIP-Seq_LNCAP_Human1.57726838
53MYBL1_21750041_ChIP-ChIP_SPERMATOCYTES_Mouse1.56300138
54TCF3_18692474_ChIP-Seq_MEFs_Mouse1.56144080
55SMAD3_22036565_ChIP-Seq_ESCs_Mouse1.55991688
56OLIG2_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.55008957
57ZFP281_27345836_Chip-Seq_ESCs_Mouse1.54146534
58TCF3_18467660_ChIP-ChIP_MESCs_Mouse1.54032009
59RNF2_27304074_Chip-Seq_NSC_Mouse1.47277888
60HOXD13_18407260_ChIP-ChIP_DEVELOPING-LIMBS_Mouse1.46675537
61FOXP3_17237761_ChIP-ChIP_TREG_Mouse1.46157922
62MYC_19079543_ChIP-ChIP_MESCs_Mouse1.46009218
63SOX2_16153702_ChIP-ChIP_HESCs_Human1.45180781
64CTBP1_25329375_ChIP-Seq_LNCAP_Human1.44884815
65MEIS1_26253404_ChIP-Seq_OPTIC_CUPS_Mouse1.44127724
66TCF7_22412390_ChIP-Seq_EML_Mouse1.44011392
67STAT3_20064451_ChIP-Seq_CD4+T_Mouse1.43286573
68RCOR1_19997604_ChIP-ChIP_NEURONS_Mouse1.42929147
69SMAD4_19686287_ChIP-ChIP_HaCaT_Human1.42227565
70AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human1.40357937
71TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.37977175
72GLI1_17442700_ChIP-ChIP_MESCs_Mouse1.37847971
73EZH2_27294783_Chip-Seq_NPCs_Mouse1.35167479
74PU_27001747_Chip-Seq_BMDM_Mouse1.33533795
75CREB1_15753290_ChIP-ChIP_HEK293T_Human1.33362366
76FOXO3_22982991_ChIP-Seq_MACROPHAGES_Mouse1.32728072
77HIF1A_21447827_ChIP-Seq_MCF-7_Human1.32024710
78VDR_23849224_ChIP-Seq_CD4+_Human1.31745558
79FOXM1_26100407_CHIP-SEQ_Hek293_flp-in_Human1.31218833
80GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.31146421
81VDR_22108803_ChIP-Seq_LS180_Human1.30330774
82TCFCP2L1_18555785_Chip-Seq_ESCs_Mouse1.30195431
83SMRT_22465074_ChIP-Seq_MACROPHAGES_Mouse1.29746127
84YY1_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse1.27778159
85UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human1.26986385
86TCF3_18692474_ChIP-Seq_MESCs_Mouse1.26970623
87KDM2B_26808549_Chip-Seq_SIL-ALL_Human1.25838137
88SMAD4_21799915_ChIP-Seq_A2780_Human1.25812653
89SCL_19346495_ChIP-Seq_HPC-7_Human1.25653728
90NANOG_16153702_ChIP-ChIP_HESCs_Human1.25451018
91NANOG_18555785_Chip-Seq_ESCs_Mouse1.25442387
92SMARCD1_25818293_ChIP-Seq_ESCs_Mouse1.25084080
93MYC_18940864_ChIP-ChIP_HL60_Human1.24724485
94SUZ12_27294783_Chip-Seq_NPCs_Mouse1.23460017
95KDM2B_26808549_Chip-Seq_HPB-ALL_Human1.22558285
96TOP2B_26459242_ChIP-Seq_MCF-7_Human1.21075859
97ESR1_15608294_ChIP-ChIP_MCF-7_Human1.20073726
98SMAD3_21741376_ChIP-Seq_EPCs_Human1.19296569
99IRF1_19129219_ChIP-ChIP_H3396_Human1.19058842
100MYC_20876797_ChIP-ChIP_MEDULLOBLASTOMA_Human1.19058007
101NCOR_22465074_ChIP-Seq_MACROPHAGES_Mouse1.18293604
102PCGF2_27294783_Chip-Seq_NPCs_Mouse1.18037748
103VDR_23401126_ChIP-Seq_LCL-AND-THP1_Human1.15971880
104BRD4_27068464_Chip-Seq_AML-cells_Mouse1.15805061
105PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human1.15513607
106KLF4_19030024_ChIP-ChIP_MESCs_Mouse1.14474039
107SMAD2/3_21741376_ChIP-Seq_EPCs_Human1.14183779
108EBF1_22473956_ChIP-Seq_BONE_MARROW_Mouse1.13872035
109MAF_26560356_Chip-Seq_TH1_Human1.13431455
110SALL4_18804426_ChIP-ChIP_MESCs_Mouse1.13132460
111TBX3_20139965_ChIP-Seq_ESCs_Mouse1.11890873
112E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse1.11730326
113TBX3_20139965_ChIP-Seq_MESCs_Mouse1.11209051
114PIAS1_25552417_ChIP-Seq_VCAP_Human1.10121744
115STAT3_23295773_ChIP-Seq_U87_Human1.10077791
116SMAD1_18555785_ChIP-Seq_MESCs_Mouse1.08332661
117FOXP2_21765815_ChIP-ChIP_NEURO2A_Mouse1.08215114
118KLF6_26769127_Chip-Seq_PDAC-Cell_line_Human1.08189916
119EP300_20729851_ChIP-Seq_FORBRAIN_MIDBRAIN_LIMB_HEART_Mouse1.06488930
120E2F1_18555785_Chip-Seq_ESCs_Mouse1.06444087
121WT1_20215353_ChIP-ChIP_NEPHRON_PROGENITOR_Mouse1.06387037
122SOX2_19030024_ChIP-ChIP_MESCs_Mouse1.06370894
123KDM2B_26808549_Chip-Seq_SUP-B15_Human1.05129112
124SOX9_26525672_Chip-Seq_HEART_Mouse1.05087250
125GATA1_26923725_Chip-Seq_HPCs_Mouse1.05021065
126ASXL1_24218140_ChIP-Seq_BMDM_Mouse1.04906271
127DMRT1_23473982_ChIP-Seq_TESTES_Mouse1.03253203
128CDKN2AIP_20523734_ChIP-Seq_CORTICAL_Neurons1.02563838
129NFE2_27457419_Chip-Seq_LIVER_Mouse1.02533494
130NELFA_20434984_ChIP-Seq_ESCs_Mouse1.02384901
131ER_23166858_ChIP-Seq_MCF-7_Human1.02300125
132NOTCH1_17114293_ChIP-ChIP_T-ALL_Human1.02237922
133TAL1_26923725_Chip-Seq_HPCs_Mouse1.02061627
134CBP_20019798_ChIP-Seq_JUKART_Human1.01834340
135IRF4_20064451_ChIP-Seq_CD4+T_Mouse1.01834340
136P53_22387025_ChIP-Seq_ESCs_Mouse1.01750741
137KDM2B_26808549_Chip-Seq_DND41_Human1.00961700
138KDM2B_26808549_Chip-Seq_JURKAT_Human1.00887916
139CMYC_18555785_Chip-Seq_ESCs_Mouse1.00306325
140MYCN_18555785_ChIP-Seq_MESCs_Mouse1.00161249
141FOXP3_21729870_ChIP-Seq_TREG_Human0.99938796
142PRDM14_21183938_ChIP-Seq_MESCs_Mouse0.99611719
143SUZ12_18555785_Chip-Seq_ESCs_Mouse0.98451729
144POU5F1_16153702_ChIP-ChIP_HESCs_Human0.98113178
145ZFP322A_24550733_ChIP-Seq_MESCs_Mouse0.98040319
146CDX2_21402776_ChIP-Seq_INTESTINAL-VILLUS_Mouse0.97908780
147ELK3_25401928_ChIP-Seq_HUVEC_Human0.97734203
148POU5F1_18358816_ChIP-ChIP_MESCs_Mouse0.97383890
149MYC_19030024_ChIP-ChIP_MESCs_Mouse0.96894233
150BRD4_25478319_ChIP-Seq_HGPS_Human0.96501149
151TEAD4_22529382_ChIP-Seq_TROPHECTODERM_Mouse0.96477048
152FLI1_21867929_ChIP-Seq_TH2_Mouse0.96068457
153THAP11_20581084_ChIP-Seq_MESCs_Mouse0.95977666
154KLF4_25985364_ChIP-Seq_ATHEROSCLEROSIS_LESION_Mouse0.95845529
155UTX_26944678_Chip-Seq_JUKART_Human0.95660557
156EZH2_22144423_ChIP-Seq_EOC_Human0.95233511
157SMAD2_18955504_ChIP-ChIP_HaCaT_Human0.94941327
158SMAD3_18955504_ChIP-ChIP_HaCaT_Human0.94941327
159MYBL2_22936984_ChIP-ChIP_MESCs_Mouse0.94853431
160SPI1_23127762_ChIP-Seq_K562_Human0.94595749
161SOX2_18555785_ChIP-Seq_MESCs_Mouse0.93532723
162RUNX1_22412390_ChIP-Seq_EML_Mouse0.93052672
163SOX2_18358816_ChIP-ChIP_MESCs_Mouse0.91322674
164IRF8_27001747_Chip-Seq_BMDM_Mouse0.91292701
165VDR_24787735_ChIP-Seq_THP-1_Human0.89231458
166NANOG_18555785_ChIP-Seq_MESCs_Mouse0.88197171
167STAT3_22323479_ChIP-Seq_MACROPHAGE_Mouse0.88136373
168RELA_24523406_ChIP-Seq_FIBROSARCOMA_Human0.87481874
169KLF4_26769127_Chip-Seq_PDAC-Cell_line_Human0.87125789
170MECOM_23826213_ChIP-Seq_KASUMI_Mouse0.86764927
171BP1_19119308_ChIP-ChIP_Hs578T_Human0.86218128
172GATA1_22025678_ChIP-Seq_K562_Human0.86005515
173Nerf2_26677805_Chip-Seq_MACROPHAGESS_Mouse0.85573841
174MYB_26560356_Chip-Seq_TH1_Human0.83921292
175NFIB_24661679_ChIP-Seq_LUNG_Mouse0.83783344
176SALL4_18804426_ChIP-ChIP_XEN_Mouse0.82590472
177POU5F1_18555785_ChIP-Seq_MESCs_Mouse0.81505649
178ISL1_27105846_Chip-Seq_CPCs_Mouse0.81232224
179DACH1_20351289_ChIP-Seq_MDA-MB-231_Human0.80720144
180MYB_26560356_Chip-Seq_TH2_Human0.79115450
181P300_27058665_Chip-Seq_ZR-75-30cells_Human0.78830855
182ZFP281_18757296_ChIP-ChIP_E14_Mouse0.78286941
183POU5F1_16518401_ChIP-PET_MESCs_Mouse0.78240819
184RING1B_27294783_Chip-Seq_NPCs_Mouse0.77875996
185KLF4_18358816_ChIP-ChIP_MESCs_Mouse0.76362662
186GATA2_22383799_ChIP-Seq_G1ME_Mouse0.76113504
187RBPJ_22232070_ChIP-Seq_NCS_Mouse0.74596107

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0003136_yellow_coat_color5.18680191
2MP0005174_abnormal_tail_pigmentation4.32119438
3MP0000569_abnormal_digit_pigmentation4.30980330
4MP0005409_darkened_coat_color3.62930716
5MP0001188_hyperpigmentation3.38825297
6MP0000015_abnormal_ear_pigmentation3.35158040
7MP0004381_abnormal_hair_follicle2.64883354
8MP0005257_abnormal_intraocular_pressure2.64023006
9MP0005076_abnormal_cell_differentiation2.35928757
10MP0009278_abnormal_bone_marrow2.33426309
11MP0010030_abnormal_orbit_morphology2.23309663
12MP0002653_abnormal_ependyma_morphology2.23043359
13MP0003880_abnormal_central_pattern2.19489439
14MP0005171_absent_coat_pigmentation2.16393649
15MP0003122_maternal_imprinting2.13361539
16MP0010352_gastrointestinal_tract_polyps2.11333527
17MP0008877_abnormal_DNA_methylation2.11158372
18MP0000778_abnormal_nervous_system2.08402756
19MP0006292_abnormal_olfactory_placode2.01267297
20MP0001299_abnormal_eye_distance/1.98902706
21MP0002102_abnormal_ear_morphology1.96491177
22MP0001529_abnormal_vocalization1.92038978
23MP0008007_abnormal_cellular_replicative1.88088637
24MP0008058_abnormal_DNA_repair1.85098973
25MP0006072_abnormal_retinal_apoptosis1.84314252
26MP0003221_abnormal_cardiomyocyte_apopto1.82780129
27MP0002233_abnormal_nose_morphology1.82529436
28MP0002009_preneoplasia1.79195716
29MP0003123_paternal_imprinting1.78608561
30MP0000383_abnormal_hair_follicle1.77612681
31MP0009379_abnormal_foot_pigmentation1.73776827
32MP0010094_abnormal_chromosome_stability1.70348402
33MP0000490_abnormal_crypts_of1.67304718
34MP0009053_abnormal_anal_canal1.65689519
35MP0001545_abnormal_hematopoietic_system1.59596339
36MP0005397_hematopoietic_system_phenotyp1.59596339
37MP0003303_peritoneal_inflammation1.57606234
38MP0002177_abnormal_outer_ear1.56770591
39MP0008057_abnormal_DNA_replication1.54539973
40MP0000049_abnormal_middle_ear1.52083986
41MP0000631_abnormal_neuroendocrine_gland1.50477822
42MP0003111_abnormal_nucleus_morphology1.49795848
43MP0003119_abnormal_digestive_system1.48944824
44MP0000371_diluted_coat_color1.48374377
45MP0006054_spinal_hemorrhage1.46208252
46MP0004133_heterotaxia1.45440198
47MP0003693_abnormal_embryo_hatching1.44629173
48MP0008995_early_reproductive_senescence1.39517401
49MP0005253_abnormal_eye_physiology1.35447394
50MP0003300_gastrointestinal_ulcer1.33262287
51MP0000647_abnormal_sebaceous_gland1.32408832
52MP0000537_abnormal_urethra_morphology1.30730058
53MP0003941_abnormal_skin_development1.29048501
54MP0002249_abnormal_larynx_morphology1.28584755
55MP0000427_abnormal_hair_cycle1.26054122
56MP0010678_abnormal_skin_adnexa1.25635181
57MP0003385_abnormal_body_wall1.24432940
58MP0002751_abnormal_autonomic_nervous1.24388375
59MP0001293_anophthalmia1.23805617
60MP0002092_abnormal_eye_morphology1.23550593
61MP0000428_abnormal_craniofacial_morphol1.23271074
62MP0001340_abnormal_eyelid_morphology1.23181974
63MP0003705_abnormal_hypodermis_morpholog1.22314448
64MP0002075_abnormal_coat/hair_pigmentati1.21967775
65MP0000350_abnormal_cell_proliferation1.21849167
66MP0002095_abnormal_skin_pigmentation1.21524032
67MP0002184_abnormal_innervation1.20776678
68MP0005248_abnormal_Harderian_gland1.20760830
69MP0002938_white_spotting1.20353041
70MP0010307_abnormal_tumor_latency1.19549128
71MP0003077_abnormal_cell_cycle1.19098318
72MP0004957_abnormal_blastocyst_morpholog1.17072878
73MP0003567_abnormal_fetal_cardiomyocyte1.16909681
74MP0003937_abnormal_limbs/digits/tail_de1.14878571
75MP0005391_vision/eye_phenotype1.14707677
76MP0004197_abnormal_fetal_growth/weight/1.14499961
77MP0000858_altered_metastatic_potential1.14258583
78MP0003861_abnormal_nervous_system1.13639419
79MP0002210_abnormal_sex_determination1.12011271
80MP0002282_abnormal_trachea_morphology1.11283582
81MP0001984_abnormal_olfaction1.10902493
82MP0003935_abnormal_craniofacial_develop1.10840917
83MP0006276_abnormal_autonomic_nervous1.10530524
84MP0009250_abnormal_appendicular_skeleto1.10490071
85MP0009703_decreased_birth_body1.09611029
86MP0000566_synostosis1.09280575
87MP0004147_increased_porphyrin_level1.09103679
88MP0003121_genomic_imprinting1.08556818
89MP0008932_abnormal_embryonic_tissue1.08465515
90MP0002086_abnormal_extraembryonic_tissu1.07455270
91MP0009697_abnormal_copulation1.07208958
92MP0000955_abnormal_spinal_cord1.06684305
93MP0000432_abnormal_head_morphology1.05573658
94MP0003755_abnormal_palate_morphology1.05297034
95MP0002085_abnormal_embryonic_tissue1.04289317
96MP0003448_altered_tumor_morphology1.03395271
97MP0003942_abnormal_urinary_system1.02868500
98MP0001324_abnormal_eye_pigmentation1.00372275
99MP0002160_abnormal_reproductive_system0.99277326
100MP0002111_abnormal_tail_morphology0.99238735
101MP0003115_abnormal_respiratory_system0.99169234
102MP0001177_atelectasis0.98861679
103MP0001186_pigmentation_phenotype0.97945365
104MP0004134_abnormal_chest_morphology0.97489828
105MP0002234_abnormal_pharynx_morphology0.97390654
106MP0002090_abnormal_vision0.96768361
107MP0003943_abnormal_hepatobiliary_system0.96338061
108MP0003566_abnormal_cell_adhesion0.95807235
109MP0005380_embryogenesis_phenotype0.95473131
110MP0001672_abnormal_embryogenesis/_devel0.95473131
111MP0004808_abnormal_hematopoietic_stem0.94251763
112MP0003453_abnormal_keratinocyte_physiol0.94092291
113MP0000534_abnormal_ureter_morphology0.92429797
114MP0001145_abnormal_male_reproductive0.91878020
115MP0000653_abnormal_sex_gland0.91626253
116MP0002638_abnormal_pupillary_reflex0.91625527
117MP0002084_abnormal_developmental_patter0.91478450
118MP0002822_catalepsy0.91029421
119MP0003938_abnormal_ear_development0.89449286
120MP0001929_abnormal_gametogenesis0.89101466
121MP0009333_abnormal_splenocyte_physiolog0.87382390
122MP0003315_abnormal_perineum_morphology0.86099462
123MP0001697_abnormal_embryo_size0.85186993
124MP0010155_abnormal_intestine_physiology0.84839284
125MP0002088_abnormal_embryonic_growth/wei0.84534968
126MP0003787_abnormal_imprinting0.84477112
127MP0002116_abnormal_craniofacial_bone0.84227517
128MP0003718_maternal_effect0.84215068
129MP0002752_abnormal_somatic_nervous0.83224143
130MP0000372_irregular_coat_pigmentation0.83075891
131MP0003786_premature_aging0.82185394
132MP0003984_embryonic_growth_retardation0.81815685
133MP0008789_abnormal_olfactory_epithelium0.81697272
134MP0002152_abnormal_brain_morphology0.80882794
135MP0001730_embryonic_growth_arrest0.80779462
136MP0002396_abnormal_hematopoietic_system0.80533673
137MP0005367_renal/urinary_system_phenotyp0.79637560
138MP0000516_abnormal_urinary_system0.79637560
139MP0005187_abnormal_penis_morphology0.76728667
140MP0002697_abnormal_eye_size0.74418472
141MP0003890_abnormal_embryonic-extraembry0.74086431
142MP0001286_abnormal_eye_development0.73232000
143MP0002080_prenatal_lethality0.73140681
144MP0002166_altered_tumor_susceptibility0.72259900
145MP0005394_taste/olfaction_phenotype0.70337203
146MP0005499_abnormal_olfactory_system0.70337203
147MP0003828_pulmonary_edema0.69340291
148MP0001915_intracranial_hemorrhage0.69123100
149MP0001919_abnormal_reproductive_system0.68177236
150MP0003091_abnormal_cell_migration0.66266329

Predicted human phenotypes

RankGene SetZ-score
1True hermaphroditism (HP:0010459)3.82242931
2Abnormal sex determination (HP:0012244)3.64761159
3Sex reversal (HP:0012245)3.64761159
4Abnormality of the labia minora (HP:0012880)3.62099215
5Stomatitis (HP:0010280)3.52964762
6Aplasia/Hypoplasia of the 4th metacarpal (HP:0010042)3.09105386
7Short 4th metacarpal (HP:0010044)3.09105386
8Intestinal atresia (HP:0011100)3.00960677
9Shoulder girdle muscle weakness (HP:0003547)3.00554732
10Genital tract atresia (HP:0001827)2.98750097
11Abnormality of the phalanges of the hallux (HP:0010057)2.96896177
12Vaginal atresia (HP:0000148)2.90481699
13Congenital primary aphakia (HP:0007707)2.89168759
14Heterotopia (HP:0002282)2.86130656
15Cortical dysplasia (HP:0002539)2.83557750
16Gait imbalance (HP:0002141)2.80577756
17Aplasia/Hypoplasia of the uvula (HP:0010293)2.79102500
18Pancreatic fibrosis (HP:0100732)2.77215824
19Nephrogenic diabetes insipidus (HP:0009806)2.74804363
20Microglossia (HP:0000171)2.74293591
21Medial flaring of the eyebrow (HP:0010747)2.69672960
22Absent speech (HP:0001344)2.69320717
23Midline defect of the nose (HP:0004122)2.67434656
24Meckel diverticulum (HP:0002245)2.62067677
25Uterine leiomyosarcoma (HP:0002891)2.59612353
26Leiomyosarcoma (HP:0100243)2.59612353
27Abnormality of the hip-girdle musculature (HP:0001445)2.57930395
28Abnormality of the musculature of the pelvis (HP:0001469)2.57930395
29Abnormality of the ileum (HP:0001549)2.56609582
30Turricephaly (HP:0000262)2.56557496
31Gastrointestinal atresia (HP:0002589)2.54649537
32Colon cancer (HP:0003003)2.44054948
33Abnormality of chromosome stability (HP:0003220)2.43186237
34Bladder carcinoma (HP:0002862)2.42374077
35Bladder neoplasm (HP:0009725)2.42374077
36Absent thumb (HP:0009777)2.41392691
37Ectopic kidney (HP:0000086)2.39231144
38Nephroblastoma (Wilms tumor) (HP:0002667)2.38216191
39Septo-optic dysplasia (HP:0100842)2.36515668
40Hypoplasia of the radius (HP:0002984)2.36361437
41Bifid tongue (HP:0010297)2.32405466
42Facial hemangioma (HP:0000329)2.31773766
43Abnormality of the lower motor neuron (HP:0002366)2.31355111
44Large earlobe (HP:0009748)2.30799623
45Transitional cell carcinoma of the bladder (HP:0006740)2.30757470
46Amyotrophic lateral sclerosis (HP:0007354)2.30183201
47Preaxial hand polydactyly (HP:0001177)2.30083731
48Pancreatic cysts (HP:0001737)2.27368116
49Aplasia/Hypoplasia of the sternum (HP:0006714)2.25959353
50Abnormality of the 4th metacarpal (HP:0010012)2.25942300
51Optic nerve hypoplasia (HP:0000609)2.25834449
52Embryonal renal neoplasm (HP:0011794)2.25402093
53Lip pit (HP:0100267)2.24776792
54Abnormality of the carotid arteries (HP:0005344)2.24599645
55Hereditary nonpolyposis colorectal carcinoma (HP:0006716)2.24122187
56Megalencephaly (HP:0001355)2.23772082
57Germ cell neoplasia (HP:0100728)2.22859106
58Abnormality of abdominal situs (HP:0011620)2.21924087
59Abdominal situs inversus (HP:0003363)2.21924087
60Poor coordination (HP:0002370)2.21004523
61Abnormality of the preputium (HP:0100587)2.21003476
62Type II lissencephaly (HP:0007260)2.17129854
63Malignant gastrointestinal tract tumors (HP:0006749)2.16663912
64Gastrointestinal carcinoma (HP:0002672)2.16663912
65Broad foot (HP:0001769)2.16630809
66Syringomyelia (HP:0003396)2.14435691
67Spinal cord lesions (HP:0100561)2.14435691
68Increased serum pyruvate (HP:0003542)2.13581133
69Medulloblastoma (HP:0002885)2.12894722
70Stenosis of the external auditory canal (HP:0000402)2.12781897
71Duodenal stenosis (HP:0100867)2.11732567
72Small intestinal stenosis (HP:0012848)2.11732567
73Absent frontal sinuses (HP:0002688)2.10952922
74Prostate neoplasm (HP:0100787)2.10484350
75Abnormality of the septum pellucidum (HP:0007375)2.10298665
76Intellectual disability, moderate (HP:0002342)2.09430843
77Anophthalmia (HP:0000528)2.09035108
78Recurrent cutaneous fungal infections (HP:0011370)2.08185376
79Chronic mucocutaneous candidiasis (HP:0002728)2.08185376
80Pelvic girdle muscle weakness (HP:0003749)2.07766054
81Esophageal atresia (HP:0002032)2.06482247
82Absent septum pellucidum (HP:0001331)2.05079298
83Increased number of teeth (HP:0011069)2.04552916
84Papillary thyroid carcinoma (HP:0002895)2.04534415
85Postaxial hand polydactyly (HP:0001162)2.04041245
86Nephronophthisis (HP:0000090)2.03743861
87Short thumb (HP:0009778)2.02961780
88Drooling (HP:0002307)2.01943219
89Atrophy/Degeneration involving motor neurons (HP:0007373)2.01535353
90Mediastinal lymphadenopathy (HP:0100721)2.00688887
91Abnormality of midbrain morphology (HP:0002418)2.00550166
92Molar tooth sign on MRI (HP:0002419)2.00550166
93Selective tooth agenesis (HP:0001592)1.99787618
94Aplasia/Hypoplasia of the optic nerve (HP:0008058)1.99332071
95Occipital encephalocele (HP:0002085)1.99321383
96Postaxial foot polydactyly (HP:0001830)1.99318228
97Atrophy/Degeneration involving the corticospinal tracts (HP:0007372)1.98674418
98Degeneration of the lateral corticospinal tracts (HP:0002314)1.98674418
99Biliary tract neoplasm (HP:0100574)1.97485649
100Abnormality of glycolysis (HP:0004366)1.96671192
101Ureteral stenosis (HP:0000071)1.96550643
102Aplasia/Hypoplasia of the tongue (HP:0010295)1.96519005
103Ureteral obstruction (HP:0006000)1.95454957
104Pseudobulbar signs (HP:0002200)1.95192055
105Impulsivity (HP:0100710)1.94911469
106Rectal prolapse (HP:0002035)1.94175379
107Amaurosis fugax (HP:0100576)1.93290647
108Hemivertebrae (HP:0002937)1.91875624
109Tracheomalacia (HP:0002779)1.91168951
110Clubbing of toes (HP:0100760)1.90882336
111Gonadotropin excess (HP:0000837)1.90793701
112Elevated erythrocyte sedimentation rate (HP:0003565)1.90612444
113Aqueductal stenosis (HP:0002410)1.90464685
114Renal duplication (HP:0000075)1.90356171
115Aplasia involving bones of the upper limbs (HP:0009823)1.90131893
116Aplasia of the phalanges of the hand (HP:0009802)1.90131893
117Aplasia involving bones of the extremities (HP:0009825)1.90131893
118Ovarian neoplasm (HP:0100615)1.89637183
119Shallow orbits (HP:0000586)1.88670446
120Abnormality of the corticospinal tract (HP:0002492)1.87656500
121Short tibia (HP:0005736)1.86798164
122Increased nuchal translucency (HP:0010880)1.86684492
123Absent radius (HP:0003974)1.86097065
124Abnormality of the fingertips (HP:0001211)1.85937008
125Skull defect (HP:0001362)1.85406057
126Lissencephaly (HP:0001339)1.84607045
127Preaxial foot polydactyly (HP:0001841)1.84318729
128Specific learning disability (HP:0001328)1.84296190
129Sclerocornea (HP:0000647)1.81892439
130Coronal craniosynostosis (HP:0004440)1.81563569
131Duplication of thumb phalanx (HP:0009942)1.81503166
132Vacuolated lymphocytes (HP:0001922)1.81502187
133Thyroid carcinoma (HP:0002890)1.81325470
134Male pseudohermaphroditism (HP:0000037)1.80415491
135Myelodysplasia (HP:0002863)1.80207400
136Hepatoblastoma (HP:0002884)1.79886201
137Alacrima (HP:0000522)1.79331144
138Mitral valve prolapse (HP:0001634)1.78479067
139Dandy-Walker malformation (HP:0001305)1.77543087
140Ocular albinism (HP:0001107)1.76987496
141Abnormality of the antihelix (HP:0009738)1.76786106
142Aplasia/Hypoplasia of the tibia (HP:0005772)1.76484110
143Decreased testicular size (HP:0008734)1.76003239
144Tubulointerstitial nephritis (HP:0001970)1.75961929
145Cutaneous finger syndactyly (HP:0010554)1.75822114
146Narrow forehead (HP:0000341)1.75556685
147Proximal placement of thumb (HP:0009623)1.74951208
148Osteolytic defects of the hand bones (HP:0009699)1.74540044
149Osteolytic defects of the phalanges of the hand (HP:0009771)1.74540044
150Testicular atrophy (HP:0000029)1.74245322
151Excessive salivation (HP:0003781)1.74028083
152Sparse lateral eyebrow (HP:0005338)1.73204370
153Cerebellar dysplasia (HP:0007033)1.72710599
154Capillary hemangiomas (HP:0005306)1.72305569
155Porencephaly (HP:0002132)1.71679730
156Abnormal lung lobation (HP:0002101)1.71453065
157Atresia of the external auditory canal (HP:0000413)1.70738876
158Aplasia involving forearm bones (HP:0009822)1.70725393
159Absent forearm bone (HP:0003953)1.70725393
160Malnutrition (HP:0004395)1.70035898
161Abnormality of the renal medulla (HP:0100957)1.69168047
162Chromosomal breakage induced by crosslinking agents (HP:0003221)1.69109742
163Short 5th finger (HP:0009237)1.69032593
164Cheilitis (HP:0100825)1.68998510
165Supernumerary spleens (HP:0009799)1.68821993
166Short middle phalanx of the 5th finger (HP:0004220)1.67968681
167Cupped ear (HP:0000378)1.67617716
168Deviation of the thumb (HP:0009603)1.67592364
169Retinal dysplasia (HP:0007973)1.67537030
170Decreased lacrimation (HP:0000633)1.67349571
171Micropenis (HP:0000054)1.67256919
172Hip dysplasia (HP:0001385)1.66489344
173Chromsome breakage (HP:0040012)1.65880103
174Progressive sensorineural hearing impairment (HP:0000408)1.65363316
175Labial hypoplasia (HP:0000066)1.65339061
176Uterine neoplasm (HP:0010784)1.64063126
177Genu recurvatum (HP:0002816)1.63014893
178Arteriovenous malformation (HP:0100026)1.62635642
179Increased density of long bones (HP:0006392)1.61544839
180Abnormality of the duodenum (HP:0002246)1.60601654
181Missing ribs (HP:0000921)1.60359861
182Plagiocephaly (HP:0001357)1.60252357
183Aplasia/Hypoplasia of the 5th finger (HP:0006262)1.60249753
184Obstructive sleep apnea (HP:0002870)1.59758159
185Recurrent abscess formation (HP:0002722)1.58866472
186Volvulus (HP:0002580)1.57480596
187Recurrent fungal infections (HP:0002841)1.55944679
188Abnormality of the peritoneum (HP:0002585)1.55346621
189Broad nasal tip (HP:0000455)1.54919274
190Periodontitis (HP:0000704)1.54845809

Predicted kinase interactions (KEA)

RankGene SetZ-score
1CASK8.53025853
2CLK16.01769635
3PNCK3.85824482
4TRIM283.73678121
5BCR3.27595036
6MKNK23.17426558
7NME23.15970249
8CDK122.76141556
9TSSK62.40030503
10MKNK12.37323951
11WNK32.35431413
12CDC72.30076969
13MAP3K42.19585607
14NEK21.95940655
15EPHA41.95592368
16CDK61.88787350
17MAP2K71.87626787
18PKN21.87144166
19IRAK31.76900389
20EPHB21.73671571
21EIF2AK11.70376079
22YES11.67604519
23NUAK11.67258697
24TNIK1.66095884
25PBK1.59900863
26BRSK21.55661559
27PLK41.49651602
28RIPK41.49599328
29FGFR21.47832176
30NEK11.47096725
31MST41.46998166
32MAP4K21.42639166
33PLK21.35855972
34MINK11.33345648
35ZAK1.28322500
36CDK191.25632654
37FGR1.25009059
38KSR11.23575121
39EPHA31.22779878
40HIPK21.19679071
41CSNK1G21.19295459
42WEE11.19248790
43MAP3K101.18698671
44PINK11.18679053
45DDR21.17781999
46PTK61.16324746
47TLK11.13131114
48WNK11.10111102
49BRD41.10047022
50ERBB31.07486703
51CDK41.06918977
52CSNK1G11.06802571
53PIM21.05848575
54ICK1.05290428
55STK31.04469612
56DYRK21.03619941
57ALK1.02516248
58MAPK131.01452696
59ACVR1B1.00135847
60BMX0.98920942
61RPS6KA40.98626200
62CDK70.97300372
63CSNK1G30.97207433
64STK38L0.95354526
65VRK10.94395215
66EIF2AK30.93260519
67TTK0.93087410
68BMPR1B0.92091335
69BUB10.92012755
70DYRK1A0.91955954
71PIM10.91584798
72TAF10.91553576
73CSNK1A1L0.91142838
74IRAK40.89808998
75CSK0.89538751
76CDK90.89333012
77MAP3K140.87355664
78PDGFRA0.86359207
79SRPK10.81021503
80NTRK20.80424434
81MARK10.80330056
82ATR0.76115658
83ERBB20.75604518
84FGFR10.74006717
85STK160.73913229
86TTN0.72705818
87JAK30.71765751
88DYRK1B0.71495643
89CAMK1G0.70692795
90BCKDK0.69739303
91MELK0.69517251
92DYRK30.69424814
93SIK30.69259630
94AKT30.65834782
95JAK20.63291562
96MAP2K40.62656894
97MET0.62401719
98MAP3K80.61863505
99MTOR0.61416256
100MAPK110.60645459
101PLK10.59715689
102PAK30.59467077
103PASK0.58955777
104MAP3K120.58860183
105CHUK0.58698164
106PRKD20.58383070
107FER0.58134524
108UHMK10.56332388
109FES0.56321706
110AURKB0.56260882
111SIK20.56215228
112FGFR30.55925610
113PAK20.55795932
114MAP3K10.55590413
115GSK3A0.55293827
116MAP3K60.53998218
117STK100.53864740
118MAPK100.53748777
119FLT30.52877574
120CHEK20.52282100
121AKT10.50124127
122LATS10.50107132
123ATM0.48538261
124CDK20.48277083
125PRKCE0.47173911
126PTK20.47138491
127PAK10.44848928
128MAP3K20.42866874
129TRIB30.42761803
130CDK180.42735429
131BRSK10.42635043
132MAP3K50.42142784
133CHEK10.41546992
134CAMKK20.40615602
135CSNK1D0.39640149
136TXK0.39232603
137AKT20.38327167
138OXSR10.37900410
139CDK140.37708808
140MAPK140.37349016
141SCYL20.35774938
142PDGFRB0.35065172
143EIF2AK20.34892993
144CSNK1E0.34736805
145PLK30.34538699
146CDK10.33900223
147PAK40.33518946
148TYK20.32207079
149NEK90.31289584
150RPS6KC10.30115639
151RPS6KL10.30115639
152CDK11A0.29776450
153MAPK10.29638104
154EGFR0.29437070
155MAP3K110.29251476
156CDK150.28611111
157NLK0.28582461
158MAPK90.28198834
159ERBB40.27839027
160RPS6KA10.27737084
161PRKDC0.27300500
162RET0.26643674
163SGK10.26346865
164CDK30.25189571

Predicted pathways (KEGG)

RankGene SetZ-score
1Steroid biosynthesis_Homo sapiens_hsa001002.90850267
2Protein export_Homo sapiens_hsa030602.71748066
3Basal transcription factors_Homo sapiens_hsa030222.58624525
4Synthesis and degradation of ketone bodies_Homo sapiens_hsa000722.54923225
5Terpenoid backbone biosynthesis_Homo sapiens_hsa009002.53382394
6Non-homologous end-joining_Homo sapiens_hsa034502.35573712
7Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa009702.29929133
8RNA degradation_Homo sapiens_hsa030182.24943527
9Propanoate metabolism_Homo sapiens_hsa006402.08131922
10DNA replication_Homo sapiens_hsa030302.03663143
11Ascorbate and aldarate metabolism_Homo sapiens_hsa000531.85955085
12Thyroid cancer_Homo sapiens_hsa052161.83321048
13NOD-like receptor signaling pathway_Homo sapiens_hsa046211.76566778
14Cell cycle_Homo sapiens_hsa041101.71735644
15Homologous recombination_Homo sapiens_hsa034401.71525427
16Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005331.68044006
17Pentose and glucuronate interconversions_Homo sapiens_hsa000401.67834247
18MicroRNAs in cancer_Homo sapiens_hsa052061.67266091
19Fanconi anemia pathway_Homo sapiens_hsa034601.65656576
20Basal cell carcinoma_Homo sapiens_hsa052171.60213293
21Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010401.59556663
22p53 signaling pathway_Homo sapiens_hsa041151.58195591
23Spliceosome_Homo sapiens_hsa030401.57592959
24Nucleotide excision repair_Homo sapiens_hsa034201.56255196
25Proteasome_Homo sapiens_hsa030501.53787497
26Chronic myeloid leukemia_Homo sapiens_hsa052201.52785329
27Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009801.48060423
28One carbon pool by folate_Homo sapiens_hsa006701.43121253
29Small cell lung cancer_Homo sapiens_hsa052221.41268143
30Nicotine addiction_Homo sapiens_hsa050331.40365479
31Colorectal cancer_Homo sapiens_hsa052101.40163236
32Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001301.39290544
33Taurine and hypotaurine metabolism_Homo sapiens_hsa004301.34936364
34Prostate cancer_Homo sapiens_hsa052151.34566271
35Endometrial cancer_Homo sapiens_hsa052131.29451196
36NF-kappa B signaling pathway_Homo sapiens_hsa040641.28926943
37Acute myeloid leukemia_Homo sapiens_hsa052211.27251782
38Wnt signaling pathway_Homo sapiens_hsa043101.25578465
39Fatty acid elongation_Homo sapiens_hsa000621.24912575
40Leishmaniasis_Homo sapiens_hsa051401.24684469
41Regulation of autophagy_Homo sapiens_hsa041401.23204271
42Adherens junction_Homo sapiens_hsa045201.23194514
43Mismatch repair_Homo sapiens_hsa034301.21122692
44RNA transport_Homo sapiens_hsa030131.20846422
45Measles_Homo sapiens_hsa051621.19367621
46Hepatitis B_Homo sapiens_hsa051611.18709983
47RNA polymerase_Homo sapiens_hsa030201.16806938
48Transcriptional misregulation in cancer_Homo sapiens_hsa052021.14706680
49HTLV-I infection_Homo sapiens_hsa051661.13777244
50Bladder cancer_Homo sapiens_hsa052191.13096461
51Circadian rhythm_Homo sapiens_hsa047101.12137432
52Viral carcinogenesis_Homo sapiens_hsa052031.10324444
53Pathogenic Escherichia coli infection_Homo sapiens_hsa051301.10323291
54Axon guidance_Homo sapiens_hsa043601.10071615
55Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa045501.08450893
56Osteoclast differentiation_Homo sapiens_hsa043801.08001905
57Cysteine and methionine metabolism_Homo sapiens_hsa002701.07952830
58Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005631.07435455
59Alcoholism_Homo sapiens_hsa050341.06390187
60TNF signaling pathway_Homo sapiens_hsa046681.06274044
61Butanoate metabolism_Homo sapiens_hsa006501.06072897
62Proteoglycans in cancer_Homo sapiens_hsa052051.05980713
63AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa049331.05501900
64Starch and sucrose metabolism_Homo sapiens_hsa005001.04004816
65mRNA surveillance pathway_Homo sapiens_hsa030151.03718138
66Apoptosis_Homo sapiens_hsa042101.03443144
67Central carbon metabolism in cancer_Homo sapiens_hsa052301.02820412
68Drug metabolism - cytochrome P450_Homo sapiens_hsa009821.02672477
69Bacterial invasion of epithelial cells_Homo sapiens_hsa051001.00170033
70Dorso-ventral axis formation_Homo sapiens_hsa043200.99645263
71Valine, leucine and isoleucine degradation_Homo sapiens_hsa002800.98214604
72Pantothenate and CoA biosynthesis_Homo sapiens_hsa007700.97290961
73Hippo signaling pathway_Homo sapiens_hsa043900.96995570
74VEGF signaling pathway_Homo sapiens_hsa043700.95919235
75T cell receptor signaling pathway_Homo sapiens_hsa046600.95587299
76Glycolysis / Gluconeogenesis_Homo sapiens_hsa000100.94104037
77Chemical carcinogenesis_Homo sapiens_hsa052040.93796704
78Selenocompound metabolism_Homo sapiens_hsa004500.91451123
79Neurotrophin signaling pathway_Homo sapiens_hsa047220.89932677
80Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008600.88320191
81Herpes simplex infection_Homo sapiens_hsa051680.87391502
82Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030080.87130784
83Toll-like receptor signaling pathway_Homo sapiens_hsa046200.86765322
84Melanogenesis_Homo sapiens_hsa049160.84498613
85Phototransduction_Homo sapiens_hsa047440.84176920
86Hedgehog signaling pathway_Homo sapiens_hsa043400.83377632
87Leukocyte transendothelial migration_Homo sapiens_hsa046700.83171797
88Notch signaling pathway_Homo sapiens_hsa043300.82366127
89Toxoplasmosis_Homo sapiens_hsa051450.82265000
90Influenza A_Homo sapiens_hsa051640.80830285
91Taste transduction_Homo sapiens_hsa047420.79893436
92Drug metabolism - other enzymes_Homo sapiens_hsa009830.79704706
93Huntingtons disease_Homo sapiens_hsa050160.79567211
94Viral myocarditis_Homo sapiens_hsa054160.79183944
95Lysine degradation_Homo sapiens_hsa003100.78712417
96mTOR signaling pathway_Homo sapiens_hsa041500.78499095
97Progesterone-mediated oocyte maturation_Homo sapiens_hsa049140.78473129
98Parkinsons disease_Homo sapiens_hsa050120.78047130
99Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005120.76647369
100Fc epsilon RI signaling pathway_Homo sapiens_hsa046640.76606617
101B cell receptor signaling pathway_Homo sapiens_hsa046620.76385889
102Tuberculosis_Homo sapiens_hsa051520.75009548
103Shigellosis_Homo sapiens_hsa051310.74821182
104Pertussis_Homo sapiens_hsa051330.74644035
105Melanoma_Homo sapiens_hsa052180.73806257
106Intestinal immune network for IgA production_Homo sapiens_hsa046720.72101436
107Natural killer cell mediated cytotoxicity_Homo sapiens_hsa046500.72030708
108Pyrimidine metabolism_Homo sapiens_hsa002400.71827399
109Primary bile acid biosynthesis_Homo sapiens_hsa001200.71670228
110Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007600.71300431
111Pancreatic cancer_Homo sapiens_hsa052120.70236205
112Purine metabolism_Homo sapiens_hsa002300.70224513
113Glioma_Homo sapiens_hsa052140.69864063
114TGF-beta signaling pathway_Homo sapiens_hsa043500.67907453
115Fc gamma R-mediated phagocytosis_Homo sapiens_hsa046660.67675676
116Tight junction_Homo sapiens_hsa045300.66888639
117Ubiquitin mediated proteolysis_Homo sapiens_hsa041200.66390645
118Other glycan degradation_Homo sapiens_hsa005110.66340296
119Type II diabetes mellitus_Homo sapiens_hsa049300.66219596
120Epstein-Barr virus infection_Homo sapiens_hsa051690.66063967
121Hepatitis C_Homo sapiens_hsa051600.65932766
122Base excision repair_Homo sapiens_hsa034100.65673750
123Pathways in cancer_Homo sapiens_hsa052000.64828294
124RIG-I-like receptor signaling pathway_Homo sapiens_hsa046220.64572023
125Fatty acid metabolism_Homo sapiens_hsa012120.63977850
126Protein processing in endoplasmic reticulum_Homo sapiens_hsa041410.63878755
127Legionellosis_Homo sapiens_hsa051340.62574009
128Chagas disease (American trypanosomiasis)_Homo sapiens_hsa051420.62373727
129Butirosin and neomycin biosynthesis_Homo sapiens_hsa005240.62236518
130GABAergic synapse_Homo sapiens_hsa047270.62214752
131Oocyte meiosis_Homo sapiens_hsa041140.61638411
132Non-small cell lung cancer_Homo sapiens_hsa052230.61578947
133Pyruvate metabolism_Homo sapiens_hsa006200.61400027
134Amoebiasis_Homo sapiens_hsa051460.60812436
135Peroxisome_Homo sapiens_hsa041460.60566473
136Regulation of actin cytoskeleton_Homo sapiens_hsa048100.60091182
137Focal adhesion_Homo sapiens_hsa045100.59714427
138Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006040.59320822
139Retrograde endocannabinoid signaling_Homo sapiens_hsa047230.59300484
140Thyroid hormone signaling pathway_Homo sapiens_hsa049190.58663482
141Glycine, serine and threonine metabolism_Homo sapiens_hsa002600.58392797
142Biosynthesis of amino acids_Homo sapiens_hsa012300.58125448
143Oxidative phosphorylation_Homo sapiens_hsa001900.57655138
144Nitrogen metabolism_Homo sapiens_hsa009100.56313663
145Salmonella infection_Homo sapiens_hsa051320.55199937
146N-Glycan biosynthesis_Homo sapiens_hsa005100.53061448
147Prolactin signaling pathway_Homo sapiens_hsa049170.51852313
148Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa005340.51707566
149Neuroactive ligand-receptor interaction_Homo sapiens_hsa040800.51245469
150Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002500.51166098
151Glutathione metabolism_Homo sapiens_hsa004800.50992045
152FoxO signaling pathway_Homo sapiens_hsa040680.49201191
153Rap1 signaling pathway_Homo sapiens_hsa040150.46290471
154Fatty acid biosynthesis_Homo sapiens_hsa000610.45558939
155Arginine and proline metabolism_Homo sapiens_hsa003300.44622065
156Carbon metabolism_Homo sapiens_hsa012000.44031225
157Folate biosynthesis_Homo sapiens_hsa007900.43845699
158Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006300.41572806
159Long-term depression_Homo sapiens_hsa047300.36391249
160Dopaminergic synapse_Homo sapiens_hsa047280.36039352
161Metabolic pathways_Homo sapiens_hsa011000.35806725
162Vasopressin-regulated water reabsorption_Homo sapiens_hsa049620.34067131
163Morphine addiction_Homo sapiens_hsa050320.31630963
164Gap junction_Homo sapiens_hsa045400.29736137

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