HNRNPLP1

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: No gene information available for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1mitochondrial calcium ion transport (GO:0006851)7.66069453
2pseudouridine synthesis (GO:0001522)7.47694274
3vitamin transmembrane transport (GO:0035461)7.42219498
4pyrimidine-containing compound transmembrane transport (GO:0072531)6.66439353
5negative regulation of transcription elongation from RNA polymerase II promoter (GO:0034244)6.59372267
6negative regulation of smooth muscle cell differentiation (GO:0051151)6.23069729
7negative regulation of DNA-templated transcription, elongation (GO:0032785)6.02607912
8positive regulation of mitochondrial calcium ion concentration (GO:0051561)5.92815969
9oligosaccharide catabolic process (GO:0009313)5.53463407
10cytokine biosynthetic process (GO:0042089)4.98919100
11regulation of mitotic spindle organization (GO:0060236)4.84474052
12DNA double-strand break processing (GO:0000729)4.78227843
13protein retention in ER lumen (GO:0006621)4.66348377
14mitotic metaphase plate congression (GO:0007080)4.63134447
15regulation of RIG-I signaling pathway (GO:0039535)4.59246624
16mitochondrial respiratory chain complex I assembly (GO:0032981)4.55569739
17NADH dehydrogenase complex assembly (GO:0010257)4.55569739
18mitochondrial respiratory chain complex I biogenesis (GO:0097031)4.55569739
19mitotic sister chromatid segregation (GO:0000070)4.44830536
20cellular protein complex localization (GO:0034629)4.43549951
21trophectodermal cell differentiation (GO:0001829)4.37561218
22maintenance of protein localization in endoplasmic reticulum (GO:0035437)4.30671401
23regulation of DNA damage checkpoint (GO:2000001)4.28470223
24negative regulation of Ras GTPase activity (GO:0034261)4.27313567
25negative regulation of DNA damage response, signal transduction by p53 class mediator (GO:0043518)4.26418744
26mitotic chromosome condensation (GO:0007076)4.15233214
27sister chromatid segregation (GO:0000819)4.05033798
28post-embryonic morphogenesis (GO:0009886)3.98454421
29regulation of viral-induced cytoplasmic pattern recognition receptor signaling pathway (GO:0039531)3.98235528
30negative regulation of T cell receptor signaling pathway (GO:0050860)3.93654443
31branching involved in prostate gland morphogenesis (GO:0060442)3.92949483
32cytokine metabolic process (GO:0042107)3.90364751
33mitochondrial calcium ion homeostasis (GO:0051560)3.90344860
34protein complex localization (GO:0031503)3.89717331
35definitive hemopoiesis (GO:0060216)3.86923421
36chemosensory behavior (GO:0007635)3.85819140
37DNA replication initiation (GO:0006270)3.85215008
38SCF-dependent proteasomal ubiquitin-dependent protein catabolic process (GO:0031146)3.82308992
39chromatin assembly (GO:0031497)3.79606296
40positive regulation of transcription elongation from RNA polymerase II promoter (GO:0032968)3.77111602
41ribosomal small subunit assembly (GO:0000028)3.76189903
42DNA catabolic process, exonucleolytic (GO:0000738)3.70192397
43histone H2A monoubiquitination (GO:0035518)3.70083676
44outer ear morphogenesis (GO:0042473)3.66090589
45cell morphogenesis involved in neuron differentiation (GO:0048667)3.62593007
46base-excision repair, AP site formation (GO:0006285)3.58070253
47NIK/NF-kappaB signaling (GO:0038061)3.53051730
48metaphase plate congression (GO:0051310)3.51042480
49histone H3-K9 methylation (GO:0051567)3.40674518
50regulation of double-strand break repair via homologous recombination (GO:0010569)3.38418940
51DNA strand renaturation (GO:0000733)3.36015141
52somatic hypermutation of immunoglobulin genes (GO:0016446)3.33081654
53somatic diversification of immune receptors via somatic mutation (GO:0002566)3.33081654
54regulation of transcription elongation from RNA polymerase II promoter (GO:0034243)3.25991012
55ribosome biogenesis (GO:0042254)3.23335334
56histone monoubiquitination (GO:0010390)3.22202662
57DNA strand elongation involved in DNA replication (GO:0006271)3.19771798
58histone H2B ubiquitination (GO:0033523)3.17828652
59pyrimidine deoxyribonucleotide catabolic process (GO:0009223)3.12018652
60chromosome organization involved in meiosis (GO:0070192)3.10228345
61DNA replication-dependent nucleosome assembly (GO:0006335)3.07462699
62DNA replication-dependent nucleosome organization (GO:0034723)3.07462699
63DNA strand elongation (GO:0022616)3.02696687
64alternative mRNA splicing, via spliceosome (GO:0000380)2.98277703
65rRNA methylation (GO:0031167)2.96307611
66regulation of spindle organization (GO:0090224)2.94837761
67positive regulation of histone methylation (GO:0031062)2.94113219
68negative regulation of antigen receptor-mediated signaling pathway (GO:0050858)2.93368618
69negative regulation of GTPase activity (GO:0034260)2.92408121
70negative regulation of GTP catabolic process (GO:0033125)2.92408121
71positive regulation of microtubule polymerization (GO:0031116)2.91938617
72protein maturation by protein folding (GO:0022417)2.90756389
73protein complex biogenesis (GO:0070271)2.87113363
74cysteine metabolic process (GO:0006534)2.84100361
75rRNA modification (GO:0000154)2.83802547
76protein localization to kinetochore (GO:0034501)2.83070018
77phenylpropanoid metabolic process (GO:0009698)2.76402884
78homocysteine metabolic process (GO:0050667)2.74618076
79positive regulation of actin cytoskeleton reorganization (GO:2000251)2.74127822
80UTP biosynthetic process (GO:0006228)2.74081887
81establishment of viral latency (GO:0019043)2.72860135
82histone methylation (GO:0016571)2.71633211
83mitotic spindle assembly checkpoint (GO:0007094)2.70166384
84peptidyl-lysine dimethylation (GO:0018027)2.69951321
85negative regulation of interleukin-17 production (GO:0032700)2.69924905
86histone H3-K9 modification (GO:0061647)2.68873591
87nuclear-transcribed mRNA poly(A) tail shortening (GO:0000289)2.68773789
88positive regulation of cell cycle checkpoint (GO:1901978)2.68687847
89telomere maintenance via semi-conservative replication (GO:0032201)2.68349058
90epithelial cell maturation (GO:0002070)2.67824290
91calcium-independent cell-cell adhesion via plasma membrane cell-adhesion molecules (GO:0016338)2.66322667
92embryonic process involved in female pregnancy (GO:0060136)2.64872096
93ribonucleoprotein complex biogenesis (GO:0022613)2.64811762
94spindle assembly checkpoint (GO:0071173)2.64631918
95positive regulation of DNA-templated transcription, elongation (GO:0032786)2.64172207
96regulation of stem cell maintenance (GO:2000036)2.63283545
97positive regulation of glycoprotein biosynthetic process (GO:0010560)2.63165029
98DNA unwinding involved in DNA replication (GO:0006268)2.60733436
99nuclear envelope reassembly (GO:0031468)2.59382022
100mitotic nuclear envelope reassembly (GO:0007084)2.59382022

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1E2F7_22180533_ChIP-Seq_HELA_Human7.63991752
2BP1_19119308_ChIP-ChIP_Hs578T_Human4.65716410
3FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse4.45893488
4E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse4.21161104
5MYBL1_21750041_ChIP-ChIP_SPERMATOCYTES_Mouse3.20011980
6STAT6_21828071_ChIP-Seq_BEAS2B_Human3.19215899
7SCL_19346495_ChIP-Seq_HPC-7_Human3.10144200
8E2F4_17652178_ChIP-ChIP_JURKAT_Human2.72099188
9FOXM1_25889361_ChIP-Seq_OE33_AND_U2OS_Human2.67930633
10FOXM1_23109430_ChIP-Seq_U2OS_Human2.67843388
11MYC_18555785_ChIP-Seq_MESCs_Mouse2.67792287
12EKLF_21900194_ChIP-Seq_ERYTHROCYTE_Mouse2.57327182
13E2F1_21310950_ChIP-Seq_MCF-7_Human2.43288397
14DCP1A_22483619_ChIP-Seq_HELA_Human2.27983420
15TBP_23326641_ChIP-Seq_C3H10T1-2_Mouse2.23919845
16MYCN_21190229_ChIP-Seq_SHEP-21N_Human2.19978284
17STAT3_22323479_ChIP-Seq_MACROPHAGE_Mouse2.18381828
18IGF1R_20145208_ChIP-Seq_DFB_Human2.08661353
19MYC_22102868_ChIP-Seq_BL_Human2.06156248
20MYC_18358816_ChIP-ChIP_MESCs_Mouse2.05362154
21EGR1_23403033_ChIP-Seq_LIVER_Mouse2.02204913
22AR_21909140_ChIP-Seq_LNCAP_Human1.93215283
23EWS_26573619_Chip-Seq_HEK293_Human1.86464451
24VDR_20736230_ChIP-Seq_LYMPHOBLASTOID_Human1.82371672
25JARID1A_20064375_ChIP-Seq_MESCs_Mouse1.80961206
26MYC_19030024_ChIP-ChIP_MESCs_Mouse1.78449696
27HCFC1_20581084_ChIP-Seq_MESCs_Mouse1.77791585
28IRF1_19129219_ChIP-ChIP_H3396_Human1.76843826
29XRN2_22483619_ChIP-Seq_HELA_Human1.68852884
30VDR_21846776_ChIP-Seq_THP-1_Human1.66798931
31PPARG_19300518_ChIP-PET_3T3-L1_Mouse1.66746309
32RUNX1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.64075239
33NELFA_20434984_ChIP-Seq_ESCs_Mouse1.60304057
34HOXB4_20404135_ChIP-ChIP_EML_Mouse1.55668240
35CHD1_19587682_ChIP-ChIP_MESCs_Mouse1.50923978
36NOTCH1_21737748_ChIP-Seq_TLL_Human1.48720314
37MYB_21317192_ChIP-Seq_ERMYB_Mouse1.48482918
38HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human1.43440225
39ETS1_20019798_ChIP-Seq_JURKAT_Human1.43115640
40FOXP3_21729870_ChIP-Seq_TREG_Human1.42841268
41YY1_22570637_ChIP-Seq_MALME-3M_Human1.41779246
42MYBL2_22936984_ChIP-ChIP_MESCs_Mouse1.38092246
43TTF2_22483619_ChIP-Seq_HELA_Human1.37892340
44PPARD_23208498_ChIP-Seq_MDA-MB-231_Human1.34762676
45SPI1_22096565_ChIP-ChIP_GC-B_Mouse1.32789517
46E2F1_18555785_ChIP-Seq_MESCs_Mouse1.31314251
47ETS2_20176728_ChIP-ChIP_TROPHOBLAST_STEM_CELLS_Mouse1.30991418
48ZFP42_18358816_ChIP-ChIP_MESCs_Mouse1.29860590
49E2F4_21247883_ChIP-Seq_LYMPHOBLASTOID_Human1.28584181
50POU5F1_18555785_ChIP-Seq_MESCs_Mouse1.26617185
51GABP_17652178_ChIP-ChIP_JURKAT_Human1.24944106
52PKCTHETA_26484144_Chip-Seq_BREAST_Human1.24687816
53SPI1_22790984_ChIP-Seq_ERYTHROLEUKEMIA_Mouse1.23481382
54CHD1_26751641_Chip-Seq_LNCaP_Human1.22871782
55ERG_20887958_ChIP-Seq_HPC-7_Mouse1.21764864
56VDR_23849224_ChIP-Seq_CD4+_Human1.20427228
57SFPI1_20887958_ChIP-Seq_HPC-7_Mouse1.20157287
58CNOT3_19339689_ChIP-ChIP_MESCs_Mouse1.19128974
59MYC_19079543_ChIP-ChIP_MESCs_Mouse1.17815395
60THAP11_20581084_ChIP-Seq_MESCs_Mouse1.14479368
61BRD4_27068464_Chip-Seq_AML-cells_Mouse1.13639251
62P300_27268052_Chip-Seq_Bcells_Human1.11310711
63ESR1_15608294_ChIP-ChIP_MCF-7_Human1.10942616
64KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human1.10717386
65GATA6_21074721_ChIP-Seq_CACO-2_Mouse1.07810509
66PDX1_19855005_ChIP-ChIP_MIN6_Mouse1.05260645
67GATA6_21074721_ChIP-Seq_CACO-2_Human1.04232248
68ELK1_19687146_ChIP-ChIP_HELA_Human1.03255585
69GABP_19822575_ChIP-Seq_HepG2_Human1.02716858
70SOX2_16153702_ChIP-ChIP_HESCs_Human1.02461435
71SREBP1_19666523_ChIP-Seq_LIVER_Mouse1.02107936
72KLF4_19030024_ChIP-ChIP_MESCs_Mouse1.01482254
73BCL6_27268052_Chip-Seq_Bcells_Human1.00868657
74CDX2_21074721_ChIP-Seq_CACO-2_Mouse1.00332160
75ZFX_18555785_ChIP-Seq_MESCs_Mouse0.99128015
76PHF8_20622853_ChIP-Seq_HELA_Human0.98571547
77PHF8_20622854_ChIP-Seq_HELA_Human0.97787389
78KDM5A_27292631_Chip-Seq_BREAST_Human0.95587572
79DACH1_20351289_ChIP-Seq_MDA-MB-231_Human0.93921930
80YY1_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse0.93492765
81SOX9_22984422_ChIP-ChIP_TESTIS_Rat0.93326010
82BCOR_27268052_Chip-Seq_Bcells_Human0.93175502
83GATA2_22383799_ChIP-Seq_G1ME_Mouse0.93032880
84STAT3_1855785_ChIP-Seq_MESCs_Mouse0.92698793
85P68_20966046_ChIP-Seq_HELA_Human0.91316671
86HSF1_23293686_ChIP-Seq_STHDH_STRIATAL_Mouse0.90510827
87TAL1_20887958_ChIP-Seq_HPC-7_Mouse0.88785779
88EBNA2_21746931_ChIP-Seq_IB4-LCL_Human0.88140824
89EST1_17652178_ChIP-ChIP_JURKAT_Human0.87005312
90NCOR1_26117541_ChIP-Seq_K562_Human0.86339467
91CCND1_20090754_ChIP-ChIP_RETINA_Mouse0.86049830
92SMAD1_18555785_ChIP-Seq_MESCs_Mouse0.86047839
93KDM2B_26808549_Chip-Seq_SIL-ALL_Human0.85410190
94CIITA_25753668_ChIP-Seq_RAJI_Human0.84245695
95SPI1_23547873_ChIP-Seq_NB4_Human0.83906733
96MYC_18940864_ChIP-ChIP_HL60_Human0.82070056
97SPI1_20517297_ChIP-Seq_HL60_Human0.82035182
98MYCN_18555785_ChIP-Seq_MESCs_Mouse0.81845291
99SA1_27219007_Chip-Seq_ERYTHROID_Human0.81299094
100RAC3_21632823_ChIP-Seq_H3396_Human0.80764329

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0003693_abnormal_embryo_hatching4.74801671
2MP0000569_abnormal_digit_pigmentation4.39757468
3MP0000566_synostosis4.33520197
4MP0005451_abnormal_body_composition4.05037334
5MP0000015_abnormal_ear_pigmentation3.22133283
6MP0005058_abnormal_lysosome_morphology2.84450481
7MP0005174_abnormal_tail_pigmentation2.80408522
8MP0003567_abnormal_fetal_cardiomyocyte2.59777460
9MP0003329_amyloid_beta_deposits2.58848046
10MP0009384_cardiac_valve_regurgitation2.55231508
11MP0002009_preneoplasia2.41745800
12MP0001348_abnormal_lacrimal_gland2.34194597
13MP0008057_abnormal_DNA_replication2.31295047
14MP0004957_abnormal_blastocyst_morpholog2.29755657
15MP0008058_abnormal_DNA_repair2.26363580
16MP0000604_amyloidosis2.25166964
17MP0003111_abnormal_nucleus_morphology2.11921768
18MP0003303_peritoneal_inflammation2.06583014
19MP0005360_urolithiasis2.05078763
20MP0001851_eye_inflammation1.99989689
21MP0001873_stomach_inflammation1.86510228
22MP0010094_abnormal_chromosome_stability1.84419182
23MP0005464_abnormal_platelet_physiology1.82084241
24MP0001730_embryonic_growth_arrest1.81389119
25MP0002396_abnormal_hematopoietic_system1.80701364
26MP0005387_immune_system_phenotype1.71059854
27MP0001790_abnormal_immune_system1.71059854
28MP0004808_abnormal_hematopoietic_stem1.69857510
29MP0009046_muscle_twitch1.60044955
30MP0002653_abnormal_ependyma_morphology1.54085256
31MP0006072_abnormal_retinal_apoptosis1.38930249
32MP0001545_abnormal_hematopoietic_system1.37148247
33MP0005397_hematopoietic_system_phenotyp1.37148247
34MP0003943_abnormal_hepatobiliary_system1.34140730
35MP0003315_abnormal_perineum_morphology1.33715905
36MP0001727_abnormal_embryo_implantation1.32594741
37MP0002160_abnormal_reproductive_system1.31413022
38MP0005332_abnormal_amino_acid1.30069094
39MP0008007_abnormal_cellular_replicative1.28055009
40MP0002138_abnormal_hepatobiliary_system1.25836018
41MP0000490_abnormal_crypts_of1.25494050
42MP0003763_abnormal_thymus_physiology1.22649393
43MP0002877_abnormal_melanocyte_morpholog1.22251028
44MP0002095_abnormal_skin_pigmentation1.21327420
45MP0003077_abnormal_cell_cycle1.19523002
46MP0002722_abnormal_immune_system1.17324868
47MP0000537_abnormal_urethra_morphology1.15878129
48MP0000689_abnormal_spleen_morphology1.14093086
49MP0003195_calcinosis1.11768215
50MP0009697_abnormal_copulation1.11637830
51MP0003718_maternal_effect1.07715949
52MP0002405_respiratory_system_inflammati1.05486116
53MP0002398_abnormal_bone_marrow1.04705845
54MP0000685_abnormal_immune_system1.04376327
55MP0002006_tumorigenesis1.00850441
56MP0008932_abnormal_embryonic_tissue0.98989034
57MP0001340_abnormal_eyelid_morphology0.96510538
58MP0000462_abnormal_digestive_system0.96103732
59MP0002909_abnormal_adrenal_gland0.95812432
60MP0002938_white_spotting0.92084871
61MP0000313_abnormal_cell_death0.91672228
62MP0004133_heterotaxia0.85503114
63MP0002080_prenatal_lethality0.84822124
64MP0001299_abnormal_eye_distance/0.83130215
65MP0000350_abnormal_cell_proliferation0.82953258
66MP0000653_abnormal_sex_gland0.80845411
67MP0003941_abnormal_skin_development0.79895739
68MP0006036_abnormal_mitochondrial_physio0.75632162
69MP0004185_abnormal_adipocyte_glucose0.75166700
70MP0002177_abnormal_outer_ear0.73992819
71MP0001145_abnormal_male_reproductive0.72565799
72MP0000598_abnormal_liver_morphology0.71947947
73MP0002429_abnormal_blood_cell0.71460792
74MP0000609_abnormal_liver_physiology0.70541276
75MP0000358_abnormal_cell_content/0.70268173
76MP0001672_abnormal_embryogenesis/_devel0.69842320
77MP0005380_embryogenesis_phenotype0.69842320
78MP0000716_abnormal_immune_system0.69760244
79MP0002233_abnormal_nose_morphology0.69215220
80MP0005410_abnormal_fertilization0.68388314
81MP0005595_abnormal_vascular_smooth0.68232586
82MP0008875_abnormal_xenobiotic_pharmacok0.67776902
83MP0002166_altered_tumor_susceptibility0.66944716
84MP0003632_abnormal_nervous_system0.66499471
85MP0001929_abnormal_gametogenesis0.66034057
86MP0003984_embryonic_growth_retardation0.65516009
87MP0003115_abnormal_respiratory_system0.64975942
88MP0009643_abnormal_urine_homeostasis0.64468969
89MP0000432_abnormal_head_morphology0.64213159
90MP0005084_abnormal_gallbladder_morpholo0.63931445
91MP0002086_abnormal_extraembryonic_tissu0.63006149
92MP0002210_abnormal_sex_determination0.62766162
93MP0005253_abnormal_eye_physiology0.62110655
94MP0000013_abnormal_adipose_tissue0.61895364
95MP0005381_digestive/alimentary_phenotyp0.59591171
96MP0002019_abnormal_tumor_incidence0.59525580
97MP0002088_abnormal_embryonic_growth/wei0.59481066
98MP0001346_abnormal_lacrimal_gland0.57732822
99MP0001915_intracranial_hemorrhage0.57484024
100MP0005389_reproductive_system_phenotype0.57372482

Predicted human phenotypes

RankGene SetZ-score
1Chromosomal breakage induced by crosslinking agents (HP:0003221)6.45785032
2Reticulocytopenia (HP:0001896)6.39810394
3Vacuolated lymphocytes (HP:0001922)6.23003395
4Chromsome breakage (HP:0040012)5.95786040
5Abnormal biliary tract physiology (HP:0012439)5.38554675
6Bile duct proliferation (HP:0001408)5.38554675
7Duplicated collecting system (HP:0000081)5.13137108
8Increased neuronal autofluorescent lipopigment (HP:0002074)4.98738535
9Abnormality of the renal collecting system (HP:0004742)4.92613600
10Abnormality of pyrimidine metabolism (HP:0004353)4.57704598
11Intracellular accumulation of autofluorescent lipopigment storage material (HP:0003204)4.45868790
12Congenital stationary night blindness (HP:0007642)4.40888968
13Confusion (HP:0001289)4.20278159
14Increased cerebral lipofuscin (HP:0011813)4.16116355
15Ectopic kidney (HP:0000086)3.87197406
16Duplication of thumb phalanx (HP:0009942)3.53763645
17Abnormality of DNA repair (HP:0003254)3.42464806
18Global brain atrophy (HP:0002283)3.36888245
19Bifid tongue (HP:0010297)3.35253046
20Septate vagina (HP:0001153)3.30162496
21Failure to thrive in infancy (HP:0001531)3.28623664
22Hypercortisolism (HP:0001578)3.21914359
23Absent rod-and cone-mediated responses on ERG (HP:0007688)3.21763573
24Optic nerve coloboma (HP:0000588)3.17225177
25Pancreatic cysts (HP:0001737)3.16786667
26Ureteral duplication (HP:0000073)3.05883591
27Absent radius (HP:0003974)3.04766141
28Abnormality of midbrain morphology (HP:0002418)2.87532232
29Molar tooth sign on MRI (HP:0002419)2.87532232
30Absent thumb (HP:0009777)2.86362801
31Pancreatic fibrosis (HP:0100732)2.85407189
32Aplasia involving forearm bones (HP:0009822)2.85050040
33Absent forearm bone (HP:0003953)2.85050040
34True hermaphroditism (HP:0010459)2.83087186
35Aplasia/Hypoplasia of the spleen (HP:0010451)2.80843937
36Asplenia (HP:0001746)2.77702169
37Recurrent cutaneous fungal infections (HP:0011370)2.77280836
38Chronic mucocutaneous candidiasis (HP:0002728)2.77280836
39Pancreatic islet-cell hyperplasia (HP:0004510)2.68264465
40Abnormal pupillary function (HP:0007686)2.64534037
41Mutism (HP:0002300)2.63682993
42Clubbing of toes (HP:0100760)2.58726326
43Agammaglobulinemia (HP:0004432)2.54760199
44Truncal obesity (HP:0001956)2.48797176
45Pheochromocytoma (HP:0002666)2.47957830
46Epiphyseal dysplasia (HP:0002656)2.46578494
47Meckel diverticulum (HP:0002245)2.46219344
48Aplasia/Hypoplasia of the uvula (HP:0010293)2.42153431
49Abnormality of the ileum (HP:0001549)2.37689845
50Horseshoe kidney (HP:0000085)2.33651885
51Abnormality of the preputium (HP:0100587)2.33572765
5211 pairs of ribs (HP:0000878)2.29835923
53Pseudobulbar signs (HP:0002200)2.29170901
54Impaired smooth pursuit (HP:0007772)2.28297458
55Esophageal neoplasm (HP:0100751)2.27570516
56Neoplasm of head and neck (HP:0012288)2.27570516
57Abnormal number of incisors (HP:0011064)2.26712167
58Hypokinesia (HP:0002375)2.24436832
59Periodontitis (HP:0000704)2.14370816
60Aplasia/Hypoplasia of the tongue (HP:0010295)2.10965130
61Viral hepatitis (HP:0006562)2.10163015
62Morphological abnormality of the pyramidal tract (HP:0002062)2.06436609
63Unilateral renal agenesis (HP:0000122)2.04893528
64Acute myeloid leukemia (HP:0004808)2.02625614
65Nephronophthisis (HP:0000090)2.01220730
66Hypergonadotropic hypogonadism (HP:0000815)1.98348936
67Abnormality of chromosome stability (HP:0003220)1.97110218
68Aplasia/Hypoplasia of the capital femoral epiphysis (HP:0005003)1.95875710
69Absent epiphyses (HP:0010577)1.95875710
70Duodenal stenosis (HP:0100867)1.92738905
71Small intestinal stenosis (HP:0012848)1.92738905
72Abnormal rod and cone electroretinograms (HP:0008323)1.92511623
73Paraparesis (HP:0002385)1.88721869
74Progressive visual loss (HP:0000529)1.87208267
75Neuroendocrine neoplasm (HP:0100634)1.85897550
76Abnormality of pyruvate family amino acid metabolism (HP:0010915)1.85854069
77Abnormality of alanine metabolism (HP:0010916)1.85854069
78Hyperalaninemia (HP:0003348)1.85854069
79Sclerocornea (HP:0000647)1.84906757
80Inability to walk (HP:0002540)1.84439678
81Hypoglycemic coma (HP:0001325)1.84205394
82Abnormality of carpal bone ossification (HP:0006257)1.82196963
83Dysostosis multiplex (HP:0000943)1.81054683
84Gastrointestinal inflammation (HP:0004386)1.81000268
85Myelodysplasia (HP:0002863)1.79460946
86Furrowed tongue (HP:0000221)1.78630078
87Capillary hemangiomas (HP:0005306)1.78018320
88Meningioma (HP:0002858)1.76897754
89Inflammation of the large intestine (HP:0002037)1.73956197
90Cerebral hemorrhage (HP:0001342)1.73711888
91Partial agenesis of the corpus callosum (HP:0001338)1.72676350
92Cystic liver disease (HP:0006706)1.71772652
93Abnormality of reticulocytes (HP:0004312)1.70938213
94Abnormality of the incisor (HP:0000676)1.70134065
95Polycythemia (HP:0001901)1.69997272
96Insomnia (HP:0100785)1.67931971
97Abnormal lung lobation (HP:0002101)1.67396224
98Abnormal delayed hypersensitivity skin test (HP:0002963)1.66781579
99Missing ribs (HP:0000921)1.65264152
100Arteriovenous malformation (HP:0100026)1.63844729

Predicted kinase interactions (KEA)

RankGene SetZ-score
1VRK26.87583965
2GRK15.76465937
3VRK13.74006606
4TIE12.93527717
5ADRBK22.71555004
6BUB12.54795548
7SMG12.54185497
8SCYL22.45548130
9CDK122.27838061
10TESK22.27355701
11TLK12.18141265
12BLK2.11755282
13FGFR32.01363157
14DDR21.98920159
15EEF2K1.95785116
16TAF11.89632016
17RPS6KB21.82408574
18CDC71.74402167
19STK31.63130093
20CHEK21.58598658
21ERN11.53508801
22ZAK1.50425016
23CDK61.46239628
24CCNB11.45318179
25NEK21.42800039
26NUAK11.40123960
27WEE11.29432603
28AKT21.20959097
29MAPKAPK51.20416242
30PBK1.19139880
31IRAK31.18820773
32CDK71.17341878
33MAP3K81.12964081
34AURKA1.08234118
35MAP3K21.07159545
36EIF2AK31.06910319
37EIF2AK21.02227479
38LATS11.00915517
39TXK1.00869043
40MAP3K141.00080923
41TYRO30.99400164
42MAP3K10.97122540
43PLK40.91009443
44PDK20.89309734
45KSR20.88578484
46CDK90.82432311
47MUSK0.79883575
48TAOK20.77957615
49DYRK1A0.77204510
50DAPK30.74943955
51CDK40.71269655
52SYK0.71173040
53TBK10.70399358
54PLK10.68592643
55ATR0.66247217
56TAOK10.64335621
57CHEK10.59179737
58MAP3K110.57634560
59STK380.57358469
60MAP3K30.51202729
61CSNK1G30.50406231
62NTRK30.49524344
63BRD40.48906262
64MAPK120.46836541
65GRK60.45195999
66ABL20.44961531
67RPS6KA50.41775864
68RPS6KC10.41288572
69RPS6KL10.41288572
70BMPR1B0.40758713
71RPS6KA60.40677133
72CDK20.39745184
73YES10.39193869
74MAP4K20.38592433
75PASK0.36637784
76MAP3K40.36077050
77MAPKAPK30.36054068
78CDK10.34396758
79CDK80.33359299
80HIPK20.33264549
81CSNK1A1L0.32299839
82DYRK30.31801465
83DAPK10.31070356
84NME20.30877307
85PTK2B0.30334205
86MAP2K20.29625712
87MAPK70.28944120
88LIMK10.28045403
89CSNK1A10.26496580
90PDGFRB0.26102708
91MAP2K10.24980425
92PIM10.24805893
93CSNK1G10.23001854
94PAK10.22930830
95FES0.22526295
96ATM0.22402035
97INSR0.22155371
98AURKB0.21468175
99PDGFRA0.21227833
100MAPK40.20757554

Predicted pathways (KEGG)

RankGene SetZ-score
1Systemic lupus erythematosus_Homo sapiens_hsa053225.25817779
2Other glycan degradation_Homo sapiens_hsa005114.64479281
3DNA replication_Homo sapiens_hsa030303.64759801
4Sulfur relay system_Homo sapiens_hsa041223.49688220
5Alcoholism_Homo sapiens_hsa050343.43917789
6Base excision repair_Homo sapiens_hsa034102.91376983
7Terpenoid backbone biosynthesis_Homo sapiens_hsa009002.70989590
8Homologous recombination_Homo sapiens_hsa034402.48651864
9Vitamin digestion and absorption_Homo sapiens_hsa049772.32685550
10Non-homologous end-joining_Homo sapiens_hsa034502.29608218
11Fanconi anemia pathway_Homo sapiens_hsa034602.29093626
12Arginine biosynthesis_Homo sapiens_hsa002202.12608860
13Transcriptional misregulation in cancer_Homo sapiens_hsa052022.04866828
14Nitrogen metabolism_Homo sapiens_hsa009101.99121170
15Vitamin B6 metabolism_Homo sapiens_hsa007501.95524041
16Spliceosome_Homo sapiens_hsa030401.95358033
17Viral carcinogenesis_Homo sapiens_hsa052031.95016338
18Cell cycle_Homo sapiens_hsa041101.92768628
19RNA degradation_Homo sapiens_hsa030181.65979305
20Mismatch repair_Homo sapiens_hsa034301.60517954
21Lysine degradation_Homo sapiens_hsa003101.51315384
22Pyrimidine metabolism_Homo sapiens_hsa002401.48660627
23Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate_Homo sapiens_hsa005321.46421013
24Phototransduction_Homo sapiens_hsa047441.45985745
25Glycosaminoglycan degradation_Homo sapiens_hsa005311.34540768
26Taurine and hypotaurine metabolism_Homo sapiens_hsa004301.24335794
27RNA transport_Homo sapiens_hsa030131.21560650
28Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030081.21454922
29Ubiquitin mediated proteolysis_Homo sapiens_hsa041201.20055783
30Sphingolipid metabolism_Homo sapiens_hsa006001.17271287
31Glycine, serine and threonine metabolism_Homo sapiens_hsa002601.17253280
32Ribosome_Homo sapiens_hsa030101.12475812
33Bladder cancer_Homo sapiens_hsa052191.08410378
34Basal transcription factors_Homo sapiens_hsa030221.08055763
35Primary immunodeficiency_Homo sapiens_hsa053401.06264137
36Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002501.06262920
37RNA polymerase_Homo sapiens_hsa030201.03601589
38Prion diseases_Homo sapiens_hsa050201.00941668
39Platelet activation_Homo sapiens_hsa046111.00724111
40Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa009700.96728692
41mRNA surveillance pathway_Homo sapiens_hsa030150.94800624
42Progesterone-mediated oocyte maturation_Homo sapiens_hsa049140.89935426
43N-Glycan biosynthesis_Homo sapiens_hsa005100.87889170
44Cysteine and methionine metabolism_Homo sapiens_hsa002700.83468245
45Sulfur metabolism_Homo sapiens_hsa009200.77187460
46Lysosome_Homo sapiens_hsa041420.74339338
47Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004000.73494573
48Maturity onset diabetes of the young_Homo sapiens_hsa049500.71689918
49Purine metabolism_Homo sapiens_hsa002300.70968285
50Oocyte meiosis_Homo sapiens_hsa041140.70360488
51Thyroid cancer_Homo sapiens_hsa052160.69161694
52alpha-Linolenic acid metabolism_Homo sapiens_hsa005920.68587155
53Fatty acid elongation_Homo sapiens_hsa000620.68527955
54Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001300.68266084
55Huntingtons disease_Homo sapiens_hsa050160.64489604
56Oxidative phosphorylation_Homo sapiens_hsa001900.64206180
57Nucleotide excision repair_Homo sapiens_hsa034200.63473546
58Intestinal immune network for IgA production_Homo sapiens_hsa046720.60954813
59Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009800.60906637
60Citrate cycle (TCA cycle)_Homo sapiens_hsa000200.59304757
61Parkinsons disease_Homo sapiens_hsa050120.58379148
62Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa005340.56127557
63Chronic myeloid leukemia_Homo sapiens_hsa052200.56052136
64Drug metabolism - other enzymes_Homo sapiens_hsa009830.55218219
65Carbon metabolism_Homo sapiens_hsa012000.53461559
66Leukocyte transendothelial migration_Homo sapiens_hsa046700.49345967
67Protein processing in endoplasmic reticulum_Homo sapiens_hsa041410.47928537
68Fatty acid metabolism_Homo sapiens_hsa012120.46414294
69Other types of O-glycan biosynthesis_Homo sapiens_hsa005140.45725756
70HTLV-I infection_Homo sapiens_hsa051660.45004328
71Renin-angiotensin system_Homo sapiens_hsa046140.41113072
72Chemical carcinogenesis_Homo sapiens_hsa052040.38785889
73Folate biosynthesis_Homo sapiens_hsa007900.35630880
74Linoleic acid metabolism_Homo sapiens_hsa005910.34809270
75Taste transduction_Homo sapiens_hsa047420.33788448
76Proteasome_Homo sapiens_hsa030500.33084227
77Biosynthesis of amino acids_Homo sapiens_hsa012300.32995877
78Pentose phosphate pathway_Homo sapiens_hsa000300.32573327
79Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006300.32512747
80Herpes simplex infection_Homo sapiens_hsa051680.31454999
81Pyruvate metabolism_Homo sapiens_hsa006200.29775845
82Metabolic pathways_Homo sapiens_hsa011000.28714023
83p53 signaling pathway_Homo sapiens_hsa041150.28388481
84Ascorbate and aldarate metabolism_Homo sapiens_hsa000530.28131609
85Pantothenate and CoA biosynthesis_Homo sapiens_hsa007700.27655264
862-Oxocarboxylic acid metabolism_Homo sapiens_hsa012100.27513576
87Glutathione metabolism_Homo sapiens_hsa004800.25482687
88Hepatitis C_Homo sapiens_hsa051600.23641442
89Phenylalanine metabolism_Homo sapiens_hsa003600.22712002
90Fatty acid degradation_Homo sapiens_hsa000710.21104929
91Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049640.20215503
92Fat digestion and absorption_Homo sapiens_hsa049750.17504315
93B cell receptor signaling pathway_Homo sapiens_hsa046620.17256025
94Alzheimers disease_Homo sapiens_hsa050100.17188344
95Serotonergic synapse_Homo sapiens_hsa047260.16415039
96Epstein-Barr virus infection_Homo sapiens_hsa051690.15561880
97Fc epsilon RI signaling pathway_Homo sapiens_hsa046640.12588934
98Cyanoamino acid metabolism_Homo sapiens_hsa004600.12375267
99Drug metabolism - cytochrome P450_Homo sapiens_hsa009820.11966437
100Olfactory transduction_Homo sapiens_hsa047400.11961674

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