ARCHS4

Functional Annotation Prediction

Predicted biological processes (GO)

Rank	Gene Set	Z-score
1	DNA packaging (GO:0006323)	9.77020460
2	sperm motility (GO:0030317)	9.51600199
3	acrosome reaction (GO:0007340)	9.03683907
4	spermatid nucleus differentiation (GO:0007289)	8.49883708
5	microtubule depolymerization (GO:0007019)	8.23288623
6	fusion of sperm to egg plasma membrane (GO:0007342)	7.96872850
7	rRNA methylation (GO:0031167)	7.90645672
8	sperm capacitation (GO:0048240)	7.66856487
9	response to pheromone (GO:0019236)	7.60667345
10	rRNA modification (GO:0000154)	7.11601325
11	single strand break repair (GO:0000012)	6.93319926
12	microtubule polymerization or depolymerization (GO:0031109)	6.83026244
13	spermatid development (GO:0007286)	6.69920161
14	sperm-egg recognition (GO:0035036)	6.32325387
15	binding of sperm to zona pellucida (GO:0007339)	6.11103598
16	plasma membrane fusion (GO:0045026)	5.83032645
17	sexual reproduction (GO:0019953)	5.53292522
18	protein polyglutamylation (GO:0018095)	5.33014077
19	centriole replication (GO:0007099)	5.29407523
20	spermatogenesis (GO:0007283)	5.22044560
21	male gamete generation (GO:0048232)	5.20736435
22	phosphatidylethanolamine biosynthetic process (GO:0006646)	5.19781001
23	reproduction (GO:0000003)	5.15279169
24	multicellular organism reproduction (GO:0032504)	5.10832444
25	regulation of centriole replication (GO:0046599)	5.05804047
26	cell-cell recognition (GO:0009988)	4.97254854
27	gamete generation (GO:0007276)	4.78038714
28	phosphatidylethanolamine metabolic process (GO:0046337)	4.74677381
29	centriole assembly (GO:0098534)	4.62891280
30	DNA conformation change (GO:0071103)	4.58393018
31	cellular ketone body metabolic process (GO:0046950)	4.49878549
32	microtubule severing (GO:0051013)	4.45143405
33	nucleosome disassembly (GO:0006337)	4.43272179
34	protein-DNA complex disassembly (GO:0032986)	4.43272179
35	cell wall macromolecule catabolic process (GO:0016998)	4.40199946
36	chromatin silencing (GO:0006342)	4.36252126
37	protein targeting to Golgi (GO:0000042)	4.32745758
38	single fertilization (GO:0007338)	4.28106425
39	calcium ion-dependent exocytosis (GO:0017156)	4.27463737
40	axonemal dynein complex assembly (GO:0070286)	4.21720297
41	nucleus organization (GO:0006997)	4.15852365
42	glycerol ether metabolic process (GO:0006662)	4.14845141
43	germ cell development (GO:0007281)	4.13489420
44	cell wall macromolecule metabolic process (GO:0044036)	4.06607269
45	establishment of protein localization to Golgi (GO:0072600)	4.03501779
46	negative regulation of inclusion body assembly (GO:0090084)	3.97135301
47	retrograde transport, vesicle recycling within Golgi (GO:0000301)	3.96989665
48	ketone body metabolic process (GO:1902224)	3.94712137
49	cellular process involved in reproduction in multicellular organism (GO:0022412)	3.86577295
50	multicellular organismal reproductive process (GO:0048609)	3.81423917
51	fertilization (GO:0009566)	3.81068635
52	male meiosis I (GO:0007141)	3.81043236
53	ether metabolic process (GO:0018904)	3.80489906
54	motile cilium assembly (GO:0044458)	3.75151823
55	mitotic chromosome condensation (GO:0007076)	3.61994006
56	histone exchange (GO:0043486)	3.59792940
57	nuclear pore complex assembly (GO:0051292)	3.55575985
58	meiosis I (GO:0007127)	3.47659095
59	negative regulation of histone methylation (GO:0031061)	3.46594050
60	regulation of Rab GTPase activity (GO:0032313)	3.44399757
61	positive regulation of Rab GTPase activity (GO:0032851)	3.44399757
62	seminiferous tubule development (GO:0072520)	3.42851218
63	negative regulation of gene expression, epigenetic (GO:0045814)	3.41111844
64	piRNA metabolic process (GO:0034587)	3.40612565
65	RNA methylation (GO:0001510)	3.38163667
66	resolution of meiotic recombination intermediates (GO:0000712)	3.37584456
67	regulation of cilium movement (GO:0003352)	3.35737641
68	RNA destabilization (GO:0050779)	3.33547700
69	mitotic metaphase plate congression (GO:0007080)	3.23125522
70	DNA topological change (GO:0006265)	3.18599892
71	synapsis (GO:0007129)	3.17951955
72	cilium or flagellum-dependent cell motility (GO:0001539)	3.14118580
73	regulation of female gonad development (GO:2000194)	3.11640190
74	regulation of histone H3-K9 methylation (GO:0051570)	3.09551224
75	regulation of histone H3-K27 methylation (GO:0061085)	3.07450047
76	protein localization to Golgi apparatus (GO:0034067)	3.04897247
77	microtubule nucleation (GO:0007020)	2.88540435
78	regulation of inclusion body assembly (GO:0090083)	2.86180625
79	male meiosis (GO:0007140)	2.79882256
80	antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-independent (G	2.78151175
81	detection of chemical stimulus involved in sensory perception of smell (GO:0050911)	2.77284483
82	homeostasis of number of cells within a tissue (GO:0048873)	2.77087837
83	DNA methylation involved in gamete generation (GO:0043046)	2.73962604
84	hematopoietic stem cell differentiation (GO:0060218)	2.72499625
85	nuclear pore organization (GO:0006999)	2.72443926
86	polyamine biosynthetic process (GO:0006596)	2.70915011
87	DNA ligation (GO:0006266)	2.69930532
88	chromosome organization involved in meiosis (GO:0070192)	2.69102346
89	regulation of chromatin binding (GO:0035561)	2.68191146
90	ribosome assembly (GO:0042255)	2.68140583
91	positive regulation of chromosome segregation (GO:0051984)	2.67471711
92	gene silencing (GO:0016458)	2.66753887
93	chromosome organization (GO:0051276)	2.66579850
94	organic cation transport (GO:0015695)	2.65191924
95	mitotic nuclear envelope disassembly (GO:0007077)	2.64265836
96	pore complex assembly (GO:0046931)	2.63993978
97	meiotic cell cycle process (GO:1903046)	2.63074950
98	regulation of transcription involved in cell fate commitment (GO:0060850)	2.62492831
99	tRNA methylation (GO:0030488)	2.60621485
100	chromosome condensation (GO:0030261)	10.3632580

Predicted upstream transcription factors (ChEA)

Rank	Gene Set	Z-score
1	TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat	6.32762538
2	SOX9_22984422_ChIP-ChIP_TESTIS_Rat	5.94495306
3	E2F7_22180533_ChIP-Seq_HELA_Human	5.14041734
4	FOXM1_23109430_ChIP-Seq_U2OS_Human	2.78754350
5	ELF1_20517297_ChIP-Seq_JURKAT_Human	2.53618290
6	MYCN_21190229_ChIP-Seq_SHEP-21N_Human	2.37358566
7	MYCN_19997598_ChIP-ChIP_NEUROBLASTOMA_Human	2.26159128
8	MYBL1_21750041_ChIP-ChIP_SPERMATOCYTES_Mouse	2.20608399
9	FOXM1_25889361_ChIP-Seq_OE33_AND_U2OS_Human	2.16759392
10	E2F4_17652178_ChIP-ChIP_JURKAT_Human	2.08115600
11	MYC_18555785_ChIP-Seq_MESCs_Mouse	1.97902082
12	RBPJ_21746931_ChIP-Seq_IB4-LCL_Human	1.86462522
13	BCL6_27268052_Chip-Seq_Bcells_Human	1.83103403
14	EBNA2_21746931_ChIP-Seq_IB4-LCL_Human	1.82552903
15	YY1_22570637_ChIP-Seq_MALME-3M_Human	1.82117831
16	P68_20966046_ChIP-Seq_HELA_Human	1.78344746
17	POU5F1_18555785_ChIP-Seq_MESCs_Mouse	1.76422723
18	RAC3_21632823_ChIP-Seq_H3396_Human	1.75909804
19	E2F1_20622854_ChIP-Seq_HELA_Human	1.75861484
20	ERA_21632823_ChIP-Seq_H3396_Human	1.73912330
21	PHF8_20622854_ChIP-Seq_HELA_Human	1.71716699
22	DMRT1_21621532_ChIP-ChIP_FETAL_Ovary	1.71196089
23	VDR_20736230_ChIP-Seq_LYMPHOBLASTOID_Human	1.70948866
24	TP63_19390658_ChIP-ChIP_HaCaT_Human	1.69190759
25	STAT6_21828071_ChIP-Seq_BEAS2B_Human	1.68594450
26	BCOR_27268052_Chip-Seq_Bcells_Human	1.65804342
27	MYC_18358816_ChIP-ChIP_MESCs_Mouse	1.63908359
28	YY1_21170310_ChIP-Seq_MESCs_Mouse	1.59254497
29	P300_27268052_Chip-Seq_Bcells_Human	1.54119420
30	CREM_20920259_ChIP-Seq_GC1-SPG_Mouse	1.53010291
31	NANOG_20526341_ChIP-Seq_ESCs_Human	1.52123334
32	WDR5_24793694_ChIP-Seq_LNCAP_Human	1.49716514
33	VDR_22108803_ChIP-Seq_LS180_Human	1.47662325
34	EKLF_21900194_ChIP-Seq_ERYTHROCYTE_Mouse	1.46816599
35	TAF2_19829295_ChIP-Seq_ESCs_Human	1.45865547
36	LXR_22292898_ChIP-Seq_THP-1_Human	1.45343685
37	SMC4_20622854_ChIP-Seq_HELA_Human	1.42965095
38	EBNA1_20929547_Chip-Seq_RAJI-cells_Human	1.42270036
39	TEAD4_26923725_Chip-Seq_HEMANGIOBLAST_Mouse	1.42208168
40	POU5F1_26923725_Chip-Seq_MESODERM_Mouse	1.42208168
41	JARID1A_20064375_ChIP-Seq_MESCs_Mouse	1.42176086
42	CTCF_20526341_ChIP-Seq_ESCs_Human	1.38368002
43	CTCF_27219007_Chip-Seq_Bcells_Human	1.37912274
44	SOX2_22085726_ChIP-Seq_NPCs_Mouse	1.37821823
45	FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse	1.36903148
46	IRF4_20064451_ChIP-Seq_CD4+T_Mouse	1.34027361
47	CBP_20019798_ChIP-Seq_JUKART_Human	1.34027361
48	SMAD2/3_21741376_ChIP-Seq_ESCs_Human	1.31340823
49	EZH2_22144423_ChIP-Seq_EOC_Human	1.29963949
50	PPARD_23208498_ChIP-Seq_MDA-MB-231_Human	1.29054217
51	SA1_27219007_Chip-Seq_Bcells_Human	1.26848907
52	TBP_23326641_ChIP-Seq_C3H10T1-2_Mouse	1.26276041
53	OCT4_20526341_ChIP-Seq_ESCs_Human	1.25908754
54	ERG_20517297_ChIP-Seq_VCAP_Human	1.24398411
55	CDX2_21074721_ChIP-Seq_CACO-2_Mouse	1.24386254
56	P53_21459846_ChIP-Seq_SAOS-2_Human	1.23089660
57	CTBP1_25329375_ChIP-Seq_LNCAP_Human	1.21345423
58	CBX2_22325352_ChIP-Seq_293T-Rex_Human	1.20358518
59	FOXP1_21924763_ChIP-Seq_HESCs_Human	1.19485957
60	NCOR1_26117541_ChIP-Seq_K562_Human	1.19097499
61	TTF2_22483619_ChIP-Seq_HELA_Human	1.18886458
62	E2F1_21310950_ChIP-Seq_MCF-7_Human	1.18454095
63	ETS1_20019798_ChIP-Seq_JURKAT_Human	1.17989687
64	RBPJ_21746931_ChIP-Seq_IB4_Human	1.17684628
65	PRDM16_22522345_ChIP-ChIP_PALATE_MESENCHYMAL_Mouse	1.17576746
66	AUTS2_25519132_ChIP-Seq_293T-REX_Human	1.16692332
67	GATA1_19941826_ChIP-Seq_K562_Human	1.16269030
68	BCL3_23251550_ChIP-Seq_MUSCLE_Mouse	1.16090793
69	HNFA_21074721_ChIP-Seq_CACO-2_Human	1.15278975
70	MYC_19829295_ChIP-Seq_ESCs_Human	1.14874721
71	CTCF_21964334_Chip-Seq_Bcells_Human	1.14069587
72	TP63_22573176_ChIP-Seq_HFKS_Human	1.13409999
73	MYC_19030024_ChIP-ChIP_MESCs_Mouse	1.12646471
74	ETV1_20927104_ChIP-Seq_GIST48_Human	1.11743553
75	SPI1_20517297_ChIP-Seq_HL60_Human	1.10396075
76	TET1_21451524_ChIP-Seq_MESCs_Mouse	1.09803180
77	HCFC1_20581084_ChIP-Seq_MESCs_Mouse	1.09034338
78	GATA6_21074721_ChIP-Seq_CACO-2_Human	1.08906159
79	SA1_27219007_Chip-Seq_ERYTHROID_Human	1.06926030
80	EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human	1.05527122
81	MYC_19079543_ChIP-ChIP_MESCs_Mouse	1.05204408
82	XRN2_22483619_ChIP-Seq_HELA_Human	1.03440553
83	ETV2_25802403_ChIP-Seq_MESCs_Mouse	1.02965890
84	ER_23166858_ChIP-Seq_MCF-7_Human	1.02919964
85	CEBPB_22108803_ChIP-Seq_LS180_Human	1.01608499
86	PHF8_20622853_ChIP-Seq_HELA_Human	1.01441040
87	CHD7_19251738_ChIP-ChIP_MESCs_Mouse	1.01368729
88	FUS_26573619_Chip-Seq_HEK293_Human	1.01274010
89	P63_20808887_ChIP-Seq_KERATINOCYTES_Human	1.00285737
90	GATA6_21074721_ChIP-Seq_CACO-2_Mouse	1.00152181
91	CREB1_15753290_ChIP-ChIP_HEK293T_Human	0.99565476
92	ZNF274_21170338_ChIP-Seq_K562_Hela	0.99424141
93	KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human	0.99262504
94	ZFP42_18358816_ChIP-ChIP_MESCs_Mouse	0.96343621
95	KDM5A_27292631_Chip-Seq_BREAST_Human	0.96041004
96	NFYB_21822215_ChIP-Seq_K562_Human	0.95552551
97	GATA3_21878914_ChIP-Seq_MCF-7_Human	0.94683955
98	TDRD3_21172665_ChIP-Seq_MCF-7_Human	0.93564367
99	CSB_26484114_Chip-Seq_FIBROBLAST_Human	0.92907954
100	SOX11_22085726_ChIP-Seq_ESNs_Mouse	0.90854478

Predicted mouse phenotypes (MGI)

Rank	Gene Set	Z-score
1	MP0005410_abnormal_fertilization	9.95177206
2	MP0001348_abnormal_lacrimal_gland	4.12930661
3	MP0003698_abnormal_male_reproductive	4.01358154
4	MP0001929_abnormal_gametogenesis	3.89970978
5	MP0003878_abnormal_ear_physiology	3.86079883
6	MP0005377_hearing/vestibular/ear_phenot	3.86079883
7	MP0005670_abnormal_white_adipose	3.61864016
8	MP0009697_abnormal_copulation	2.91554141
9	MP0005379_endocrine/exocrine_gland_phen	2.83325139
10	MP0000678_abnormal_parathyroid_gland	2.78924763
11	MP0002132_abnormal_respiratory_system	2.56410999
12	MP0005451_abnormal_body_composition	2.52776648
13	MP0003077_abnormal_cell_cycle	2.43325003
14	MP0003718_maternal_effect	2.42730163
15	MP0002210_abnormal_sex_determination	2.33739907
16	MP0002161_abnormal_fertility/fecundity	2.29813095
17	MP0010094_abnormal_chromosome_stability	2.16353235
18	MP0003111_abnormal_nucleus_morphology	2.14236823
19	MP0003646_muscle_fatigue	1.94439893
20	MP0004957_abnormal_blastocyst_morpholog	1.93340309
21	MP0001145_abnormal_male_reproductive	1.90279625
22	MP0000653_abnormal_sex_gland	1.80213517
23	MP0003011_delayed_dark_adaptation	1.80149276
24	MP0003693_abnormal_embryo_hatching	1.68976926
25	MP0008058_abnormal_DNA_repair	1.66935392
26	MP0008007_abnormal_cellular_replicative	1.66733328
27	MP0008995_early_reproductive_senescence	1.62844710
28	MP0005397_hematopoietic_system_phenotyp	1.61081840
29	MP0001545_abnormal_hematopoietic_system	1.61081840
30	MP0008877_abnormal_DNA_methylation	1.54532468
31	MP0003786_premature_aging	1.47829023
32	MP0008057_abnormal_DNA_replication	1.46562048
33	MP0009278_abnormal_bone_marrow	1.40030029
34	MP0006292_abnormal_olfactory_placode	1.32963564
35	MP0005253_abnormal_eye_physiology	1.28694731
36	MP0005083_abnormal_biliary_tract	1.23832537
37	MP0002249_abnormal_larynx_morphology	1.20114456
38	MP0000681_abnormal_thyroid_gland	1.11087382
39	MP0005551_abnormal_eye_electrophysiolog	1.04888805
40	MP0002822_catalepsy	1.03323622
41	MP0006072_abnormal_retinal_apoptosis	0.99389612
42	MP0001529_abnormal_vocalization	0.99022109
43	MP0005666_abnormal_adipose_tissue	0.96558178
44	MP0000313_abnormal_cell_death	0.89930470
45	MP0009115_abnormal_fat_cell	0.85911158
46	MP0001730_embryonic_growth_arrest	0.84520532
47	MP0005167_abnormal_blood-brain_barrier	0.79890360
48	MP0002163_abnormal_gland_morphology	0.79279940
49	MP0005645_abnormal_hypothalamus_physiol	0.75993491
50	MP0002282_abnormal_trachea_morphology	0.73919303
51	MP0004036_abnormal_muscle_relaxation	0.73023872
52	MP0002396_abnormal_hematopoietic_system	0.71794804
53	MP0008932_abnormal_embryonic_tissue	0.71561762
54	MP0000534_abnormal_ureter_morphology	0.71457471
55	MP0005391_vision/eye_phenotype	0.70503026
56	MP0003699_abnormal_female_reproductive	0.69083506
57	MP0009379_abnormal_foot_pigmentation	0.68384224
58	MP0002229_neurodegeneration	0.68202718
59	MP0003950_abnormal_plasma_membrane	0.68116889
60	MP0004808_abnormal_hematopoietic_stem	0.67881617
61	MP0001119_abnormal_female_reproductive	0.65854109
62	MP0005375_adipose_tissue_phenotype	0.64942416
63	MP0006036_abnormal_mitochondrial_physio	0.64911008
64	MP0002160_abnormal_reproductive_system	0.64826066
65	MP0005636_abnormal_mineral_homeostasis	0.63827663
66	MP0003283_abnormal_digestive_organ	0.63168690
67	MP0002080_prenatal_lethality	0.62554372
68	MP0005310_abnormal_salivary_gland	0.62487370
69	MP0008770_decreased_survivor_rate	0.62364041
70	MP0002127_abnormal_cardiovascular_syste	0.61928837
71	MP0001765_abnormal_ion_homeostasis	0.61073541
72	MP0010307_abnormal_tumor_latency	0.59663534
73	MP0000350_abnormal_cell_proliferation	0.58855026
74	MP0001764_abnormal_homeostasis	0.58625882
75	MP0006035_abnormal_mitochondrial_morpho	0.57368288
76	MP0001661_extended_life_span	0.55971988
77	MP0001963_abnormal_hearing_physiology	0.54566738
78	MP0000613_abnormal_salivary_gland	0.50244328
79	MP0002019_abnormal_tumor_incidence	0.48673602
80	MP0000026_abnormal_inner_ear	0.46168923
81	MP0004233_abnormal_muscle_weight	0.45761145
82	MP0005423_abnormal_somatic_nervous	0.45713725
83	MP0005395_other_phenotype	0.45395193
84	MP0003115_abnormal_respiratory_system	0.45288401
85	MP0001697_abnormal_embryo_size	0.44842483
86	MP0005380_embryogenesis_phenotype	0.44259517
87	MP0001672_abnormal_embryogenesis/_devel	0.44259517
88	MP0002085_abnormal_embryonic_tissue	0.42870667
89	MP0005332_abnormal_amino_acid	0.42748192
90	MP0002234_abnormal_pharynx_morphology	0.42533956
91	MP0003936_abnormal_reproductive_system	0.41782728
92	MP0004084_abnormal_cardiac_muscle	0.41205991
93	MP0001340_abnormal_eyelid_morphology	0.41109256
94	MP0000703_abnormal_thymus_morphology	0.40776286
95	MP0000003_abnormal_adipose_tissue	0.40298957
96	MP0002970_abnormal_white_adipose	0.39784700
97	MP0001486_abnormal_startle_reflex	0.39205358
98	MP0001293_anophthalmia	0.39190515
99	MP0000609_abnormal_liver_physiology	0.38270656
100	MP0002269_muscular_atrophy	0.37543562

Predicted human phenotypes

Rank	Gene Set	Z-score
1	Severe visual impairment (HP:0001141)	6.63579856
2	Bony spicule pigmentary retinopathy (HP:0007737)	4.87375439
3	Tubulointerstitial nephritis (HP:0001970)	4.66220979
4	Attenuation of retinal blood vessels (HP:0007843)	4.33177806
5	Aplasia/Hypoplasia of the earlobes (HP:0009906)	4.08507519
6	Aplasia/Hypoplasia of the sacrum (HP:0008517)	3.81123648
7	Abnormality of macular pigmentation (HP:0008002)	3.63746228
8	Male infertility (HP:0003251)	3.52978173
9	Parkinsonism with favorable response to dopaminergic medication (HP:0002548)	3.48307580
10	Abnormal rod and cone electroretinograms (HP:0008323)	3.48186842
11	Asymmetric septal hypertrophy (HP:0001670)	3.37747912
12	Dynein arm defect of respiratory motile cilia (HP:0012255)	3.32899072
13	Absent/shortened dynein arms (HP:0200106)	3.32899072
14	Chronic hepatic failure (HP:0100626)	3.31532025
15	Abnormal spermatogenesis (HP:0008669)	3.28444004
16	Azoospermia (HP:0000027)	3.27946531
17	Resting tremor (HP:0002322)	3.19797655
18	Hypoplasia of the thymus (HP:0000778)	3.16916710
19	Generalized aminoaciduria (HP:0002909)	3.05239877
20	Infertility (HP:0000789)	3.00191525
21	Abnormal respiratory motile cilium physiology (HP:0012261)	2.92893411
22	Facial shape deformation (HP:0011334)	2.90086569
23	Potter facies (HP:0002009)	2.90086569
24	Abnormal ciliary motility (HP:0012262)	2.88298014
25	11 pairs of ribs (HP:0000878)	2.81127747
26	Scotoma (HP:0000575)	2.79240909
27	Hyperthyroidism (HP:0000836)	2.76331088
28	Renal Fanconi syndrome (HP:0001994)	2.71735436
29	Supernumerary spleens (HP:0009799)	2.68135881
30	Bell-shaped thorax (HP:0001591)	2.60766214
31	Impulsivity (HP:0100710)	2.60486545
32	Nasal polyposis (HP:0100582)	2.59678376
33	Truncus arteriosus (HP:0001660)	2.57045499
34	Hyperkalemia (HP:0002153)	2.56567334
35	Abnormal urine output (HP:0012590)	2.54634305
36	Chromsome breakage (HP:0040012)	2.53087576
37	Renovascular hypertension (HP:0100817)	2.52717029
38	Abnormal respiratory epithelium morphology (HP:0012253)	2.49699761
39	Abnormal respiratory motile cilium morphology (HP:0005938)	2.49699761
40	Subcapsular cataract (HP:0000523)	2.49211609
41	Chromosomal breakage induced by crosslinking agents (HP:0003221)	2.47817351
42	Aplasia/Hypoplasia of the thymus (HP:0010515)	2.43035656
43	Central scotoma (HP:0000603)	2.36278483
44	Seborrheic dermatitis (HP:0001051)	2.35907047
45	Aplastic anemia (HP:0001915)	2.35287400
46	Small intestinal stenosis (HP:0012848)	2.34705821
47	Duodenal stenosis (HP:0100867)	2.34705821
48	Congenital stationary night blindness (HP:0007642)	2.27457471
49	Retinal dysplasia (HP:0007973)	2.27207693
50	Cone-rod dystrophy (HP:0000548)	2.26830591
51	Abnormality of cochlea (HP:0000375)	2.26564146
52	Menstrual irregularities (HP:0000858)	2.25090399
53	Progressive sensorineural hearing impairment (HP:0000408)	2.24553804
54	Respiratory insufficiency due to defective ciliary clearance (HP:0200073)	2.23510633
55	Reticulocytosis (HP:0001923)	2.21771192
56	Aplasia/Hypoplasia of the uvula (HP:0010293)	2.19944892
57	Polyuria (HP:0000103)	2.16726273
58	Abnormality of DNA repair (HP:0003254)	2.15381759
59	Hepatocellular necrosis (HP:0001404)	2.14182358
60	Hypoalphalipoproteinemia (HP:0003233)	2.10872687
61	Abnormality of lateral ventricle (HP:0030047)	2.10471171
62	Hyponatremia (HP:0002902)	2.09928572
63	Hypoparathyroidism (HP:0000829)	2.09415936
64	Abnormality of the duodenum (HP:0002246)	2.05241043
65	Short middle phalanx of the 5th finger (HP:0004220)	2.02959608
66	Tubulointerstitial abnormality (HP:0001969)	2.02180878
67	Cerebellar dysplasia (HP:0007033)	2.01784819
68	Sandal gap (HP:0001852)	2.00141212
69	Abnormal ventriculo-arterial connection (HP:0011563)	1.98816003
70	Transposition of the great arteries (HP:0001669)	1.98816003
71	Abnormal connection of the cardiac segments (HP:0011545)	1.98816003
72	Abnormality of renal excretion (HP:0011036)	1.98516507
73	Abnormality of the ileum (HP:0001549)	1.97365061
74	Intellectual disability, moderate (HP:0002342)	1.97160444
75	Abnormality of dental color (HP:0011073)	1.95469805
76	Abnormality of the preputium (HP:0100587)	1.94595739
77	Hypergonadotropic hypogonadism (HP:0000815)	1.94189824
78	Meckel diverticulum (HP:0002245)	1.94177877
79	Abnormality of reticulocytes (HP:0004312)	1.92292180
80	Increased purine levels (HP:0004368)	1.91913492
81	Hyperuricemia (HP:0002149)	1.91913492
82	Hepatic necrosis (HP:0002605)	1.90705249
83	Progressive hearing impairment (HP:0001730)	1.89974710
84	Abnormality of renal resorption (HP:0011038)	1.88547226
85	Stage 5 chronic kidney disease (HP:0003774)	1.86772771
86	Mitochondrial inheritance (HP:0001427)	1.86524025
87	Acute myeloid leukemia (HP:0004808)	1.85637192
88	Abnormality of the nasal mucosa (HP:0000433)	1.85365965
89	Abnormality of chloride homeostasis (HP:0011422)	1.85118049
90	Upper limb muscle weakness (HP:0003484)	1.84220199
91	Postural instability (HP:0002172)	1.83278004
92	Bowel incontinence (HP:0002607)	1.82337709
93	Rhabdomyolysis (HP:0003201)	1.78760660
94	Optic disc pallor (HP:0000543)	1.78030335
95	Nephronophthisis (HP:0000090)	1.77028022
96	Abnormality of the tricuspid valve (HP:0001702)	1.75047979
97	Abnormal large intestine physiology (HP:0012700)	1.74574481
98	Double outlet right ventricle (HP:0001719)	1.74264941
99	Congenital malformation of the right heart (HP:0011723)	1.74264941
100	Abnormality of chromosome stability (HP:0003220)	1.73677420

Predicted kinase interactions (KEA)

Rank	Gene Set	Z-score
1	PLK4	8.05563404
2	TESK2	5.98863308
3	TESK1	3.76832453
4	ZAK	2.97819266
5	BRD4	2.54225480
6	DDR2	2.42325869
7	TLK1	2.12118286
8	INSRR	2.07483187
9	PBK	2.04285769
10	PLK2	2.03486142
11	CDK12	2.00970302
12	MAP4K2	1.83448399
13	VRK1	1.80502044
14	CDK7	1.75886083
15	FLT3	1.67869106
16	TTK	1.64064613
17	STK38	1.58211588
18	PNCK	1.57422782
19	PIK3CG	1.53886958
20	CAMK1G	1.49862804
21	BUB1	1.48654511
22	VRK2	1.41244250
23	CDC7	1.31190355
24	CHEK2	1.15983923
25	NEK1	1.15214878
26	MAP3K8	1.11064183
27	AURKA	1.08902399
28	MST1R	1.07349853
29	BRSK1	1.05267686
30	SCYL2	1.04314979
31	KDR	1.03146518
32	CDK3	0.96039827
33	CHEK1	0.93458473
34	TAF1	0.89594563
35	MAP3K11	0.88183496
36	DYRK3	0.87236291
37	PDK1	0.86248909
38	NME2	0.84541270
39	PLK1	0.83213609
40	KIT	0.80079770
41	ICK	0.79039874
42	CDK4	0.78948344
43	NEK2	0.78011263
44	CDK2	0.76094525
45	PDPK1	0.76085184
46	SMG1	0.74891731
47	AURKB	0.74133427
48	BRAF	0.72045506
49	WEE1	0.71694339
50	CDK1	0.71238770
51	ATR	0.70687051
52	CLK1	0.70548488
53	CSF1R	0.70515153
54	LATS2	0.67713653
55	BRSK2	0.67656438
56	NUAK1	0.66930460
57	PRKG2	0.66026932
58	MAPK15	0.64900306
59	WNK4	0.64648099
60	CAMK1D	0.64487192
61	WNK1	0.63247710
62	MST4	0.61350456
63	PINK1	0.60969081
64	PRKD3	0.59285251
65	DYRK1B	0.59166312
66	UHMK1	0.58812086
67	SRPK1	0.56029671
68	PTK2B	0.55943847
69	TYRO3	0.53252937
70	MTOR	0.52886134
71	EIF2AK1	0.52081243
72	MAPK11	0.51509964
73	RPS6KA1	0.51006056
74	RPS6KA5	0.47112608
75	GRK1	0.45852524
76	CCNB1	0.45629915
77	SIK2	0.44591539
78	GSK3B	0.44450645
79	CDK9	0.42028181
80	KSR2	0.40303017
81	PRKG1	0.40245114
82	NME1	0.39295042
83	MAPK1	0.38921971
84	RPS6KC1	0.36498742
85	RPS6KL1	0.36498742
86	PAK1	0.36305136
87	ATM	0.34884087
88	MAPK14	0.34786745
89	AKT2	0.33903784
90	PLK3	0.33508574
91	MINK1	0.30356471
92	CSNK2A2	0.28490164
93	LMTK2	0.27770622
94	RPS6KB2	0.26867291
95	MAP3K2	0.26128928
96	RPS6KA6	0.25370584
97	CSNK2A1	0.25252973
98	PRKCH	0.25224611
99	MAP2K2	0.24235220
100	AKT1	0.23875835

Predicted pathways (KEGG)

Rank	Gene Set	Z-score
1	Synthesis and degradation of ketone bodies_Homo sapiens_hsa00072	5.03170896
2	Fatty acid biosynthesis_Homo sapiens_hsa00061	4.22955345
3	DNA replication_Homo sapiens_hsa03030	3.34548090
4	Olfactory transduction_Homo sapiens_hsa04740	2.86742320
5	RNA transport_Homo sapiens_hsa03013	2.75297572
6	Base excision repair_Homo sapiens_hsa03410	2.55340849
7	Fanconi anemia pathway_Homo sapiens_hsa03460	2.53659684
8	Mismatch repair_Homo sapiens_hsa03430	2.42252439
9	Homologous recombination_Homo sapiens_hsa03440	2.19643455
10	Spliceosome_Homo sapiens_hsa03040	2.10925763
11	Ribosome_Homo sapiens_hsa03010	2.10551684
12	Huntingtons disease_Homo sapiens_hsa05016	2.08673050
13	Systemic lupus erythematosus_Homo sapiens_hsa05322	2.06201668
14	Oxidative phosphorylation_Homo sapiens_hsa00190	2.00222341
15	Selenocompound metabolism_Homo sapiens_hsa00450	1.90931573
16	One carbon pool by folate_Homo sapiens_hsa00670	1.90548347
17	Cell cycle_Homo sapiens_hsa04110	1.84004631
18	Ribosome biogenesis in eukaryotes_Homo sapiens_hsa03008	1.80666800
19	Non-homologous end-joining_Homo sapiens_hsa03450	1.73710273
20	Butanoate metabolism_Homo sapiens_hsa00650	1.72666961
21	Parkinsons disease_Homo sapiens_hsa05012	1.71139983
22	Nucleotide excision repair_Homo sapiens_hsa03420	1.70617689
23	mRNA surveillance pathway_Homo sapiens_hsa03015	1.66157887
24	Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa00970	1.64623503
25	Cardiac muscle contraction_Homo sapiens_hsa04260	1.62185899
26	Proteasome_Homo sapiens_hsa03050	1.58360145
27	RNA polymerase_Homo sapiens_hsa03020	1.57081679
28	Basal transcription factors_Homo sapiens_hsa03022	1.51249276
29	Phototransduction_Homo sapiens_hsa04744	1.51176227
30	Pyrimidine metabolism_Homo sapiens_hsa00240	1.50668257
31	Purine metabolism_Homo sapiens_hsa00230	1.46925655
32	Protein processing in endoplasmic reticulum_Homo sapiens_hsa04141	1.46006030
33	Pyruvate metabolism_Homo sapiens_hsa00620	1.41681060
34	Fatty acid metabolism_Homo sapiens_hsa01212	1.41171908
35	Glycolysis / Gluconeogenesis_Homo sapiens_hsa00010	1.32403761
36	Alcoholism_Homo sapiens_hsa05034	1.25331346
37	Glycerophospholipid metabolism_Homo sapiens_hsa00564	1.22929581
38	Nicotinate and nicotinamide metabolism_Homo sapiens_hsa00760	1.21107227
39	Biosynthesis of amino acids_Homo sapiens_hsa01230	1.12273163
40	Antigen processing and presentation_Homo sapiens_hsa04612	1.11861463
41	Oocyte meiosis_Homo sapiens_hsa04114	1.10739151
42	Carbon metabolism_Homo sapiens_hsa01200	1.07289788
43	Viral carcinogenesis_Homo sapiens_hsa05203	1.06646176
44	Progesterone-mediated oocyte maturation_Homo sapiens_hsa04914	1.02924525
45	Transcriptional misregulation in cancer_Homo sapiens_hsa05202	1.02632534
46	Arginine biosynthesis_Homo sapiens_hsa00220	0.96654532
47	Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa04932	0.96379926
48	Alzheimers disease_Homo sapiens_hsa05010	0.94079715
49	Arginine and proline metabolism_Homo sapiens_hsa00330	0.93355572
50	Phenylalanine metabolism_Homo sapiens_hsa00360	0.86971871
51	Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa00630	0.84107535
52	Propanoate metabolism_Homo sapiens_hsa00640	0.81174882
53	Fat digestion and absorption_Homo sapiens_hsa04975	0.71842160
54	Allograft rejection_Homo sapiens_hsa05330	0.71660363
55	N-Glycan biosynthesis_Homo sapiens_hsa00510	0.70704785
56	Fatty acid degradation_Homo sapiens_hsa00071	0.68711100
57	Metabolic pathways_Homo sapiens_hsa01100	0.67301529
58	Autoimmune thyroid disease_Homo sapiens_hsa05320	0.66690410
59	RNA degradation_Homo sapiens_hsa03018	0.64814622
60	Glutathione metabolism_Homo sapiens_hsa00480	0.63644051
61	Type I diabetes mellitus_Homo sapiens_hsa04940	0.63396643
62	Taste transduction_Homo sapiens_hsa04742	0.62679615
63	Lysine degradation_Homo sapiens_hsa00310	0.62511565
64	Ubiquitin mediated proteolysis_Homo sapiens_hsa04120	0.61992388
65	Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa00400	0.59685869
66	Folate biosynthesis_Homo sapiens_hsa00790	0.59309013
67	Valine, leucine and isoleucine degradation_Homo sapiens_hsa00280	0.58529108
68	Porphyrin and chlorophyll metabolism_Homo sapiens_hsa00860	0.57920422
69	Steroid biosynthesis_Homo sapiens_hsa00100	0.57836491
70	Type II diabetes mellitus_Homo sapiens_hsa04930	0.57460877
71	Herpes simplex infection_Homo sapiens_hsa05168	0.55553242
72	Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa04961	0.55339825
73	Epstein-Barr virus infection_Homo sapiens_hsa05169	0.54562526
74	Tyrosine metabolism_Homo sapiens_hsa00350	0.50263142
75	Cysteine and methionine metabolism_Homo sapiens_hsa00270	0.49249520
76	Sulfur relay system_Homo sapiens_hsa04122	0.48828283
77	Graft-versus-host disease_Homo sapiens_hsa05332	0.46090745
78	Adipocytokine signaling pathway_Homo sapiens_hsa04920	0.43899400
79	Longevity regulating pathway - multiple species_Homo sapiens_hsa04213	0.43776951
80	Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa00130	0.43635292
81	Acute myeloid leukemia_Homo sapiens_hsa05221	0.42634586
82	Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate_Homo sapiens_hsa00532	0.42428376
83	Other types of O-glycan biosynthesis_Homo sapiens_hsa00514	0.36984281
84	p53 signaling pathway_Homo sapiens_hsa04115	0.34397732
85	Maturity onset diabetes of the young_Homo sapiens_hsa04950	0.34125004
86	Renin-angiotensin system_Homo sapiens_hsa04614	0.33049167
87	Fatty acid elongation_Homo sapiens_hsa00062	0.27773849
88	Neuroactive ligand-receptor interaction_Homo sapiens_hsa04080	0.27720919
89	Primary immunodeficiency_Homo sapiens_hsa05340	0.27453416
90	Viral myocarditis_Homo sapiens_hsa05416	0.26810567
91	Protein digestion and absorption_Homo sapiens_hsa04974	0.26758503
92	Retinol metabolism_Homo sapiens_hsa00830	0.25174833
93	HTLV-I infection_Homo sapiens_hsa05166	0.20238186
94	Influenza A_Homo sapiens_hsa05164	0.19735802
95	Hedgehog signaling pathway_Homo sapiens_hsa04340	0.18985382
96	Peroxisome_Homo sapiens_hsa04146	0.18803658
97	Butirosin and neomycin biosynthesis_Homo sapiens_hsa00524	0.17873360
98	Glycine, serine and threonine metabolism_Homo sapiens_hsa00260	0.15771124
99	Thyroid hormone signaling pathway_Homo sapiens_hsa04919	0.13922437
100	PPAR signaling pathway_Homo sapiens_hsa03320	0.13512532

HNRNPLP2

Functional Annotation Prediction

Predicted biological processes (GO)

Predicted upstream transcription factors (ChEA)

Predicted mouse phenotypes (MGI)

Predicted human phenotypes

Predicted kinase interactions (KEA)

Predicted pathways (KEGG)

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