HNRNPMP1

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: No gene information available for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1regulation of female receptivity (GO:0045924)7.33754131
2establishment of nucleus localization (GO:0040023)6.44984879
3female mating behavior (GO:0060180)6.38317035
4attachment of spindle microtubules to kinetochore (GO:0008608)5.08481609
5meiotic chromosome segregation (GO:0045132)4.87886989
6rRNA modification (GO:0000154)4.75069686
7replication fork processing (GO:0031297)4.53899180
8rRNA methylation (GO:0031167)4.53202372
9relaxation of smooth muscle (GO:0044557)4.35928401
10kinetochore organization (GO:0051383)4.16405295
11histone H2A acetylation (GO:0043968)4.16072827
12DNA double-strand break processing (GO:0000729)4.13147748
13kinetochore assembly (GO:0051382)4.11696837
14negative regulation of axon extension involved in axon guidance (GO:0048843)4.11013194
15centriole replication (GO:0007099)3.90581113
16mitotic sister chromatid cohesion (GO:0007064)3.90143193
17maintenance of fidelity involved in DNA-dependent DNA replication (GO:0045005)3.84523561
18nucleus localization (GO:0051647)3.78344837
19resolution of meiotic recombination intermediates (GO:0000712)3.73237663
20multicellular organismal reproductive behavior (GO:0033057)3.72618922
21chromatin remodeling at centromere (GO:0031055)3.70590677
22microtubule anchoring (GO:0034453)3.70553899
23mitotic sister chromatid segregation (GO:0000070)3.61224343
24CENP-A containing nucleosome assembly (GO:0034080)3.59233395
25negative regulation of T cell receptor signaling pathway (GO:0050860)3.55212778
26protein K6-linked ubiquitination (GO:0085020)3.51933221
27negative regulation of translation, ncRNA-mediated (GO:0040033)3.49209084
28regulation of translation, ncRNA-mediated (GO:0045974)3.49209084
29negative regulation of translation involved in gene silencing by miRNA (GO:0035278)3.49209084
30negative regulation by host of viral transcription (GO:0043922)3.45785075
31neuron projection extension involved in neuron projection guidance (GO:1902284)3.44240645
32axon extension involved in axon guidance (GO:0048846)3.44240645
33oxidative demethylation (GO:0070989)3.41184511
34ectodermal placode formation (GO:0060788)3.37079095
35sister chromatid segregation (GO:0000819)3.35061077
36negative regulation of axon guidance (GO:1902668)3.34874395
37histone exchange (GO:0043486)3.24125623
38detection of mechanical stimulus involved in sensory perception of sound (GO:0050910)3.21606058
39DNA demethylation (GO:0080111)3.21587760
40centriole assembly (GO:0098534)3.18343961
41positive regulation by host of viral transcription (GO:0043923)3.17438956
42indolalkylamine metabolic process (GO:0006586)3.15400129
43DNA strand renaturation (GO:0000733)3.13800899
44indole-containing compound catabolic process (GO:0042436)3.13459512
45indolalkylamine catabolic process (GO:0046218)3.13459512
46tryptophan catabolic process (GO:0006569)3.13459512
47DNA ligation (GO:0006266)3.12811950
48histone-serine phosphorylation (GO:0035404)3.12539655
49spindle checkpoint (GO:0031577)3.10760489
50tachykinin receptor signaling pathway (GO:0007217)3.09972703
51negative regulation of DNA-dependent DNA replication (GO:2000104)3.08478554
52axoneme assembly (GO:0035082)3.01333798
53retinal rod cell development (GO:0046548)3.00051359
54transmission of nerve impulse (GO:0019226)2.98921788
55postreplication repair (GO:0006301)2.98537797
56cardiolipin metabolic process (GO:0032048)2.97386666
57limb bud formation (GO:0060174)2.97258890
58negative regulation of antigen receptor-mediated signaling pathway (GO:0050858)2.97234214
59retinal ganglion cell axon guidance (GO:0031290)2.95723012
60NLS-bearing protein import into nucleus (GO:0006607)2.94344857
61mitotic spindle checkpoint (GO:0071174)2.93512629
62translesion synthesis (GO:0019985)2.91062307
63DNA replication checkpoint (GO:0000076)2.90054744
64negative regulation of DNA recombination (GO:0045910)2.89907526
65protein-chromophore linkage (GO:0018298)2.89060242
66otic vesicle formation (GO:0030916)2.86353370
67tryptophan metabolic process (GO:0006568)2.83696774
68regulation of centriole replication (GO:0046599)2.83535359
69positive regulation of male gonad development (GO:2000020)2.81332075
70limb development (GO:0060173)2.81298629
71appendage development (GO:0048736)2.81298629
72tRNA splicing, via endonucleolytic cleavage and ligation (GO:0006388)2.81223086
73RNA splicing, via endonucleolytic cleavage and ligation (GO:0000394)2.81223086
74positive regulation of inositol phosphate biosynthetic process (GO:0060732)2.80451279
75forebrain neuron differentiation (GO:0021879)2.80224796
76negative regulation of axon extension (GO:0030517)2.77064341
77recombinational repair (GO:0000725)2.77005689
78histone H3-K4 trimethylation (GO:0080182)2.76894740
79forebrain morphogenesis (GO:0048853)2.75684565
80double-strand break repair via homologous recombination (GO:0000724)2.74591018
81establishment of protein localization to mitochondrial membrane (GO:0090151)2.72676389
82DNA catabolic process, exonucleolytic (GO:0000738)2.72415709
83negative regulation of G2/M transition of mitotic cell cycle (GO:0010972)2.71343794
84methionine biosynthetic process (GO:0009086)2.70215135
85spinal cord development (GO:0021510)2.69115770
86negative regulation of JUN kinase activity (GO:0043508)2.68507041
87negative regulation of mitotic metaphase/anaphase transition (GO:0045841)2.68350053
88negative regulation of metaphase/anaphase transition of cell cycle (GO:1902100)2.68350053
89negative regulation of mitotic sister chromatid segregation (GO:0033048)2.68350053
90negative regulation of mitotic sister chromatid separation (GO:2000816)2.68350053
91negative regulation of sister chromatid segregation (GO:0033046)2.68350053
92DNA damage response, detection of DNA damage (GO:0042769)2.64322307
93signal peptide processing (GO:0006465)2.64258548
94cellular response to sterol (GO:0036315)2.63401378
95negative regulation of chromosome segregation (GO:0051985)2.63339232
96regulation of timing of cell differentiation (GO:0048505)2.62802110
97L-methionine biosynthetic process from methylthioadenosine (GO:0019509)2.60315353
98protein localization to kinetochore (GO:0034501)2.59366673
99V(D)J recombination (GO:0033151)2.58664627
100brain morphogenesis (GO:0048854)2.58556294

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1E2F7_22180533_ChIP-Seq_HELA_Human4.25534333
2E2F4_17652178_ChIP-ChIP_JURKAT_Human3.50380444
3FOXM1_23109430_ChIP-Seq_U2OS_Human3.25624125
4GLI1_17442700_ChIP-ChIP_MESCs_Mouse3.13009072
5E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse2.98222687
6MYCN_21190229_ChIP-Seq_SHEP-21N_Human2.84936040
7EWS_26573619_Chip-Seq_HEK293_Human2.81598203
8FUS_26573619_Chip-Seq_HEK293_Human2.76386770
9CEBPD_23245923_ChIP-Seq_MEFs_Mouse2.75282897
10SALL1_21062744_ChIP-ChIP_HESCs_Human2.60111088
11KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human2.46850774
12ZNF274_21170338_ChIP-Seq_K562_Hela2.44858063
13FOXM1_25889361_ChIP-Seq_OE33_AND_U2OS_Human2.38026710
14TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse2.31984471
15POU3F2_20337985_ChIP-ChIP_501MEL_Human2.31868341
16GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse2.25012100
17TAF15_26573619_Chip-Seq_HEK293_Human2.24069371
18P300_19829295_ChIP-Seq_ESCs_Human2.16706701
19GBX2_23144817_ChIP-Seq_PC3_Human2.16576786
20VDR_22108803_ChIP-Seq_LS180_Human2.15137185
21NOTCH1_21737748_ChIP-Seq_TLL_Human2.12135301
22EST1_17652178_ChIP-ChIP_JURKAT_Human2.09846094
23PRDM16_22522345_ChIP-ChIP_PALATE_MESENCHYMAL_Mouse2.01404075
24CTBP2_25329375_ChIP-Seq_LNCAP_Human1.97765387
25CTBP1_25329375_ChIP-Seq_LNCAP_Human1.87558285
26HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human1.86648101
27ZFP322A_24550733_ChIP-Seq_MESCs_Mouse1.80474151
28ZFP57_27257070_Chip-Seq_ESCs_Mouse1.77174550
29ELK1_19687146_ChIP-ChIP_HELA_Human1.75982035
30FLI1_27457419_Chip-Seq_LIVER_Mouse1.71096866
31IGF1R_20145208_ChIP-Seq_DFB_Human1.70018331
32EZH2_22144423_ChIP-Seq_EOC_Human1.68982821
33ER_23166858_ChIP-Seq_MCF-7_Human1.67130217
34AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human1.66652373
35EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human1.63419113
36BCL11B_21912641_ChIP-Seq_STHDH_STRIUM_Mouse1.58702123
37CHD1_19587682_ChIP-ChIP_MESCs_Mouse1.57449945
38MYC_20876797_ChIP-ChIP_MEDULLOBLASTOMA_Human1.55448067
39MEIS1_26253404_ChIP-Seq_OPTIC_CUPS_Mouse1.55419316
40GABP_17652178_ChIP-ChIP_JURKAT_Human1.51515156
41POU5F1_16153702_ChIP-ChIP_HESCs_Human1.49547399
42TEAD4_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.49486961
43POU5F1_26923725_Chip-Seq_MESODERM_Mouse1.49486961
44IRF1_19129219_ChIP-ChIP_H3396_Human1.41840469
45SMARCD1_25818293_ChIP-Seq_ESCs_Mouse1.41352949
46BCAT_22108803_ChIP-Seq_LS180_Human1.39267734
47STAT3_23295773_ChIP-Seq_U87_Human1.38871753
48CBP_20019798_ChIP-Seq_JUKART_Human1.38529296
49IRF4_20064451_ChIP-Seq_CD4+T_Mouse1.38529296
50VDR_23849224_ChIP-Seq_CD4+_Human1.38135333
51SMAD4_21799915_ChIP-Seq_A2780_Human1.35611906
52PPARG_23326641_ChIP-Seq_C3H10T1-2_Mouse1.34648999
53UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human1.32578217
54RBPJ_22232070_ChIP-Seq_NCS_Mouse1.29901491
55NANOG_19829295_ChIP-Seq_ESCs_Human1.29432457
56SOX2_19829295_ChIP-Seq_ESCs_Human1.29432457
57HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse1.29395121
58ELF1_17652178_ChIP-ChIP_JURKAT_Human1.26215651
59TRIM28_17542650_ChIP-ChIP_NTERA2_Human1.24672143
60FOXP3_21729870_ChIP-Seq_TREG_Human1.24663117
61TCF4_22108803_ChIP-Seq_LS180_Human1.24494144
62TCF4_23295773_ChIP-Seq_U87_Human1.21894803
63PADI4_21655091_ChIP-ChIP_MCF-7_Human1.21147892
64PIAS1_25552417_ChIP-Seq_VCAP_Human1.20446194
65KDM5B_21448134_ChIP-Seq_MESCs_Mouse1.19287676
66MYC_18940864_ChIP-ChIP_HL60_Human1.18666043
67CEBPB_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.18294215
68TOP2B_26459242_ChIP-Seq_MCF-7_Human1.16953623
69SMAD3_21741376_ChIP-Seq_EPCs_Human1.15105610
70TCFCP2L1_18555785_Chip-Seq_ESCs_Mouse1.14241672
71PCGF2_27294783_Chip-Seq_ESCs_Mouse1.12985988
72FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse1.11411121
73SMAD2/3_21741376_ChIP-Seq_EPCs_Human1.10493522
74AR_21909140_ChIP-Seq_LNCAP_Human1.10294950
75AR_25329375_ChIP-Seq_VCAP_Human1.06330530
76E2F1_21310950_ChIP-Seq_MCF-7_Human1.06131553
77SMARCA4_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.04604996
78OLIG2_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.04543432
79FOXM1_26456572_ChIP-Seq_MCF-7_Human1.04042764
80CDKN2AIP_20523734_ChIP-Seq_CORTICAL_Neurons1.03708281
81NANOG_18555785_Chip-Seq_ESCs_Mouse1.03096654
82AR_21572438_ChIP-Seq_LNCaP_Human1.00722994
83FOXO3_22982991_ChIP-Seq_MACROPHAGES_Mouse1.00649336
84TP53_22573176_ChIP-Seq_HFKS_Human0.99866899
85FLI1_21867929_ChIP-Seq_TH2_Mouse0.99863055
86GRHL2_25758223_ChIP-Seq_PLACENTA_Mouse0.99238266
87PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human0.99127778
88TEAD4_22529382_ChIP-Seq_TROPHECTODERM_Mouse0.99104571
89PCGF2_27294783_Chip-Seq_NPCs_Mouse0.97799483
90NR3C1_21868756_ChIP-Seq_MCF10A_Human0.96991971
91RUNX2_22187159_ChIP-Seq_PCA_Human0.95797448
92EZH2_27294783_Chip-Seq_NPCs_Mouse0.94310727
93FOXA1_21572438_ChIP-Seq_LNCaP_Human0.93760975
94SUZ12_27294783_Chip-Seq_NPCs_Mouse0.91657118
95NFE2_27457419_Chip-Seq_LIVER_Mouse0.91326205
96FOXA1_27197147_Chip-Seq_ENDOMETRIOID-ADENOCARCINOMA_Human0.91245740
97RUNX1_26923725_Chip-Seq_MACROPHAGESS_Mouse0.91104784
98SMAD4_21741376_ChIP-Seq_EPCs_Human0.89849008
99CDX2_22108803_ChIP-Seq_LS180_Human0.89574617
100ZNF652_21678463_ChIP-ChIP_ZR75-1_Human0.87170520

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0003136_yellow_coat_color8.33329813
2MP0010094_abnormal_chromosome_stability3.23504703
3MP0002163_abnormal_gland_morphology2.96680966
4MP0009780_abnormal_chondrocyte_physiolo2.93878455
5MP0008058_abnormal_DNA_repair2.86215924
6MP0002653_abnormal_ependyma_morphology2.77494749
7MP0009697_abnormal_copulation2.67393781
8MP0000372_irregular_coat_pigmentation2.40875951
9MP0008057_abnormal_DNA_replication2.32773314
10MP0005187_abnormal_penis_morphology2.31236385
11MP0002132_abnormal_respiratory_system2.19108465
12MP0006072_abnormal_retinal_apoptosis2.14127561
13MP0002928_abnormal_bile_duct2.06729125
14MP0003111_abnormal_nucleus_morphology2.03842488
15MP0001485_abnormal_pinna_reflex1.93694965
16MP0002938_white_spotting1.93662570
17MP0005646_abnormal_pituitary_gland1.90683369
18MP0005174_abnormal_tail_pigmentation1.82925384
19MP0008872_abnormal_physiological_respon1.79056882
20MP0002638_abnormal_pupillary_reflex1.78140536
21MP0005551_abnormal_eye_electrophysiolog1.76848256
22MP0005379_endocrine/exocrine_gland_phen1.75521087
23MP0008007_abnormal_cellular_replicative1.75021982
24MP0003718_maternal_effect1.74005164
25MP0006292_abnormal_olfactory_placode1.72074329
26MP0008877_abnormal_DNA_methylation1.66215850
27MP0003077_abnormal_cell_cycle1.62366546
28MP0001984_abnormal_olfaction1.61082975
29MP0005171_absent_coat_pigmentation1.55379203
30MP0002736_abnormal_nociception_after1.50511125
31MP0004885_abnormal_endolymph1.49782355
32MP0006276_abnormal_autonomic_nervous1.49352534
33MP0003943_abnormal_hepatobiliary_system1.48783310
34MP0005253_abnormal_eye_physiology1.44220626
35MP0000647_abnormal_sebaceous_gland1.40769136
36MP0001851_eye_inflammation1.39618830
37MP0001293_anophthalmia1.38157282
38MP0004381_abnormal_hair_follicle1.36370807
39MP0002102_abnormal_ear_morphology1.34444843
40MP0002282_abnormal_trachea_morphology1.21858515
41MP0008775_abnormal_heart_ventricle1.21680179
42MP0004215_abnormal_myocardial_fiber1.19402505
43MP0001929_abnormal_gametogenesis1.17838357
44MP0004130_abnormal_muscle_cell1.15120974
45MP0005391_vision/eye_phenotype1.13484216
46MP0008932_abnormal_embryonic_tissue1.07956278
47MP0000631_abnormal_neuroendocrine_gland1.07830803
48MP0003693_abnormal_embryo_hatching1.06436949
49MP0001502_abnormal_circadian_rhythm1.04498244
50MP0006036_abnormal_mitochondrial_physio1.00741236
51MP0005645_abnormal_hypothalamus_physiol0.99953278
52MP0003698_abnormal_male_reproductive0.97843239
53MP0005083_abnormal_biliary_tract0.97046331
54MP0005423_abnormal_somatic_nervous0.95538025
55MP0003936_abnormal_reproductive_system0.95034638
56MP0002210_abnormal_sex_determination0.94741692
57MP0001286_abnormal_eye_development0.92996804
58MP0001486_abnormal_startle_reflex0.91371125
59MP0002277_abnormal_respiratory_mucosa0.87648770
60MP0003121_genomic_imprinting0.86981929
61MP0000383_abnormal_hair_follicle0.86972582
62MP0001963_abnormal_hearing_physiology0.86244085
63MP0004957_abnormal_blastocyst_morpholog0.85627470
64MP0010307_abnormal_tumor_latency0.84807011
65MP0009745_abnormal_behavioral_response0.84559285
66MP0000653_abnormal_sex_gland0.83835960
67MP0002090_abnormal_vision0.83120872
68MP0002095_abnormal_skin_pigmentation0.81431119
69MP0008789_abnormal_olfactory_epithelium0.81107889
70MP0002751_abnormal_autonomic_nervous0.80703418
71MP0001346_abnormal_lacrimal_gland0.79540202
72MP0001119_abnormal_female_reproductive0.78778562
73MP0001968_abnormal_touch/_nociception0.78595541
74MP0003786_premature_aging0.76959852
75MP0003638_abnormal_response/metabolism_0.75011476
76MP0003755_abnormal_palate_morphology0.73442130
77MP0005084_abnormal_gallbladder_morpholo0.72895504
78MP0000569_abnormal_digit_pigmentation0.72813629
79MP0005167_abnormal_blood-brain_barrier0.72559993
80MP0002233_abnormal_nose_morphology0.71966336
81MP0001529_abnormal_vocalization0.71699486
82MP0000778_abnormal_nervous_system0.70250763
83MP0002067_abnormal_sensory_capabilities0.69130232
84MP0000516_abnormal_urinary_system0.69108163
85MP0005367_renal/urinary_system_phenotyp0.69108163
86MP0001145_abnormal_male_reproductive0.68719077
87MP0002092_abnormal_eye_morphology0.68104722
88MP0000049_abnormal_middle_ear0.65284927
89MP0006035_abnormal_mitochondrial_morpho0.63422338
90MP0005410_abnormal_fertilization0.63267210
91MP0009046_muscle_twitch0.62071136
92MP0000427_abnormal_hair_cycle0.61706238
93MP0002272_abnormal_nervous_system0.61639767
94MP0000026_abnormal_inner_ear0.61528178
95MP0002572_abnormal_emotion/affect_behav0.61296916
96MP0008875_abnormal_xenobiotic_pharmacok0.60644847
97MP0005195_abnormal_posterior_eye0.60507628
98MP0003880_abnormal_central_pattern0.60449367
99MP0000015_abnormal_ear_pigmentation0.60422676
100MP0001501_abnormal_sleep_pattern0.59270782

Predicted human phenotypes

RankGene SetZ-score
1Severe visual impairment (HP:0001141)5.75083644
2True hermaphroditism (HP:0010459)4.43660666
3Oligodactyly (hands) (HP:0001180)3.99425012
4Aplasia/Hypoplasia of the uvula (HP:0010293)3.90443893
5Tubular atrophy (HP:0000092)3.47451896
6Intestinal atresia (HP:0011100)3.39185480
7Chromosomal breakage induced by crosslinking agents (HP:0003221)3.36763030
8Pancreatic fibrosis (HP:0100732)3.36516692
9Nephronophthisis (HP:0000090)3.28026420
10Pancreatic cysts (HP:0001737)3.20520437
11Fibular hypoplasia (HP:0003038)3.15777131
12Esophageal atresia (HP:0002032)3.08944350
1311 pairs of ribs (HP:0000878)3.08507174
14Meckel diverticulum (HP:0002245)3.00363500
15Abnormality of the duodenum (HP:0002246)3.00036872
16Abnormality of chromosome stability (HP:0003220)2.94217608
17Abnormality of the ileum (HP:0001549)2.93146394
18Chromsome breakage (HP:0040012)2.93001397
19Birth length less than 3rd percentile (HP:0003561)2.89067679
20Abnormal drinking behavior (HP:0030082)2.87580784
21Polydipsia (HP:0001959)2.87580784
22Abnormality of the preputium (HP:0100587)2.86479672
23Gastrointestinal atresia (HP:0002589)2.83356466
24Oligodactyly (HP:0012165)2.82545786
25Abnormality of the carotid arteries (HP:0005344)2.78364020
26Abnormality of the renal medulla (HP:0100957)2.75477962
27Congenital stationary night blindness (HP:0007642)2.74374802
28Volvulus (HP:0002580)2.70934039
29Chronic hepatic failure (HP:0100626)2.59116905
30Hypoplastic iliac wings (HP:0002866)2.58041850
31Hemiparesis (HP:0001269)2.56747155
32Small intestinal stenosis (HP:0012848)2.56385394
33Duodenal stenosis (HP:0100867)2.56385394
34Respiratory insufficiency due to defective ciliary clearance (HP:0200073)2.55307266
35Cystic liver disease (HP:0006706)2.54356931
36Concave nail (HP:0001598)2.52287668
37Abnormality of midbrain morphology (HP:0002418)2.47240179
38Molar tooth sign on MRI (HP:0002419)2.47240179
39Hyperventilation (HP:0002883)2.45425337
40Abnormality of the renal cortex (HP:0011035)2.44572731
41Clubbing of toes (HP:0100760)2.39639668
42Sloping forehead (HP:0000340)2.39491932
43Colon cancer (HP:0003003)2.33989622
44Abnormal rod and cone electroretinograms (HP:0008323)2.28332212
45Aplasia/Hypoplasia of the fibula (HP:0006492)2.27475369
46Triphalangeal thumb (HP:0001199)2.27153445
47Tubulointerstitial abnormality (HP:0001969)2.20689452
48Congenital hepatic fibrosis (HP:0002612)2.18920106
49Abnormality of the labia minora (HP:0012880)2.17685043
50Occipital encephalocele (HP:0002085)2.16364115
51Sclerocornea (HP:0000647)2.13808542
52Thyroiditis (HP:0100646)2.12446196
53Anencephaly (HP:0002323)2.12004312
54Acute necrotizing encephalopathy (HP:0006965)2.11246739
55Aplasia/Hypoplasia of the tongue (HP:0010295)2.09100611
56Furrowed tongue (HP:0000221)2.08721369
57Progressive macrocephaly (HP:0004481)2.08183716
58Acute encephalopathy (HP:0006846)2.06113960
59Hypoplasia of the capital femoral epiphysis (HP:0003090)2.03421668
60Polyuria (HP:0000103)2.02920773
61Tubulointerstitial nephritis (HP:0001970)2.00655253
62Tubulointerstitial fibrosis (HP:0005576)2.00229043
63Astigmatism (HP:0000483)1.99684946
64Anophthalmia (HP:0000528)1.98223965
65Absent thumb (HP:0009777)1.94720787
66Missing ribs (HP:0000921)1.94530349
67Hemivertebrae (HP:0002937)1.93981504
68Increased nuchal translucency (HP:0010880)1.90968909
69Tented upper lip vermilion (HP:0010804)1.89445266
70Conjunctival hamartoma (HP:0100780)1.89343678
71Neoplasm of the adrenal gland (HP:0100631)1.88429201
72Postaxial foot polydactyly (HP:0001830)1.87858631
73Optic nerve coloboma (HP:0000588)1.87675403
74Gaze-evoked nystagmus (HP:0000640)1.87271086
75Attenuation of retinal blood vessels (HP:0007843)1.86903617
76Supernumerary spleens (HP:0009799)1.85418076
77Hematochezia (HP:0002573)1.83638433
78Male pseudohermaphroditism (HP:0000037)1.83373871
79Medial flaring of the eyebrow (HP:0010747)1.83044582
80Rib fusion (HP:0000902)1.82833426
81Abnormality of the diencephalon (HP:0010662)1.82353781
82Type II lissencephaly (HP:0007260)1.81914982
83Bony spicule pigmentary retinopathy (HP:0007737)1.80854266
84Rhinitis (HP:0012384)1.79486131
85Abnormal mitochondria in muscle tissue (HP:0008316)1.78565683
86Holoprosencephaly (HP:0001360)1.77768494
87Myelodysplasia (HP:0002863)1.76782334
88Anal stenosis (HP:0002025)1.75445052
89Short chin (HP:0000331)1.75219018
90Abnormal respiratory motile cilium physiology (HP:0012261)1.74038562
91Short thumb (HP:0009778)1.73806415
92Long clavicles (HP:0000890)1.73348683
93Large for gestational age (HP:0001520)1.72581870
94Abnormal number of incisors (HP:0011064)1.72469497
95Hypothermia (HP:0002045)1.72115568
96Aplasia involving forearm bones (HP:0009822)1.71707299
97Absent forearm bone (HP:0003953)1.71707299
98Dandy-Walker malformation (HP:0001305)1.71601480
99Hypoplasia of the fovea (HP:0007750)1.68374489
100Aplasia/Hypoplasia of the fovea (HP:0008060)1.68374489

Predicted kinase interactions (KEA)

RankGene SetZ-score
1MAPK156.24849266
2FRK4.60074713
3BUB14.48402884
4PNCK3.77613112
5VRK13.31562884
6WEE12.80740183
7TSSK62.68569894
8ACVR1B2.65922896
9PLK42.38947101
10MST41.97691697
11PLK31.91212701
12WNK31.85692341
13VRK21.84505841
14ZAK1.81889332
15BRSK21.71537247
16NEK21.70524321
17PLK21.68034147
18NTRK21.66262859
19NEK11.49245432
20NUAK11.48446134
21EPHA41.47810233
22TRIM281.45613316
23BMPR1B1.45110230
24MKNK21.38202581
25ADRBK21.37547232
26TAOK31.32444481
27EIF2AK31.31341729
28TTK1.23578624
29INSRR1.18602622
30MAP4K21.16738939
31CDC71.16636376
32CDK31.15511624
33ERBB31.05566946
34MAP3K41.05416197
35STK161.03599737
36BCR0.97345479
37BRSK10.95550879
38NLK0.92285123
39MELK0.90948405
40MAP2K70.88910781
41FGFR20.86806146
42CDK80.86130007
43YES10.86002910
44PINK10.84712439
45TNIK0.84369975
46MKNK10.83684868
47ATR0.81587922
48SRPK10.80393134
49CAMKK20.78648386
50PLK10.75710748
51MAPK130.67054733
52ADRBK10.66911339
53AKT30.66106819
54PBK0.64782499
55AURKB0.62683499
56ATM0.61199302
57STK390.61089920
58PAK20.57723093
59GRK10.56319299
60CAMK1G0.54494437
61TEC0.54454618
62OXSR10.52737628
63EIF2AK20.51382076
64KIT0.49990449
65CSNK1G10.49878409
66STK40.49555239
67TAF10.49247668
68STK30.48205613
69PAK30.46677030
70EIF2AK10.46172228
71PIM20.44809644
72MAPKAPK30.43222913
73NME10.42722142
74PTK2B0.42103741
75CSNK1G30.40196625
76CSNK1A1L0.40009298
77CDK120.39691321
78TGFBR10.35736023
79CHEK20.35611374
80ERBB20.34678157
81CHEK10.34452606
82PRKCG0.32377251
83CAMK1D0.29492561
84CSNK1G20.28259539
85DYRK20.27607913
86ROCK10.25085811
87PRKDC0.25065415
88GSK3A0.23810770
89PRKCE0.22851968
90CASK0.21480587
91CLK10.21071970
92CSNK2A20.20816012
93CDK70.20224935
94CDK10.20020123
95CSNK2A10.19759923
96STK100.19638370
97MINK10.19407337
98ABL10.16375443
99RPS6KB10.15440134
100STK38L0.14836652

Predicted pathways (KEGG)

RankGene SetZ-score
1Fanconi anemia pathway_Homo sapiens_hsa034603.83879452
2RNA polymerase_Homo sapiens_hsa030203.38573758
3Homologous recombination_Homo sapiens_hsa034403.04037028
4Non-homologous end-joining_Homo sapiens_hsa034502.93401675
5Nitrogen metabolism_Homo sapiens_hsa009102.63550614
6One carbon pool by folate_Homo sapiens_hsa006702.63458703
7DNA replication_Homo sapiens_hsa030302.62545246
8Mismatch repair_Homo sapiens_hsa034302.39361093
9Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030082.26389426
10Tryptophan metabolism_Homo sapiens_hsa003802.25395019
11Proteasome_Homo sapiens_hsa030502.25297565
12Primary bile acid biosynthesis_Homo sapiens_hsa001201.94730401
13Base excision repair_Homo sapiens_hsa034101.93394068
14Cell cycle_Homo sapiens_hsa041101.91930204
15Butanoate metabolism_Homo sapiens_hsa006501.84391680
16Sulfur relay system_Homo sapiens_hsa041221.84056025
17Basal transcription factors_Homo sapiens_hsa030221.83407412
18Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001301.81328979
19Synthesis and degradation of ketone bodies_Homo sapiens_hsa000721.76222850
20Neuroactive ligand-receptor interaction_Homo sapiens_hsa040801.75958523
21RNA degradation_Homo sapiens_hsa030181.72304210
22Fatty acid elongation_Homo sapiens_hsa000621.66655945
23Parkinsons disease_Homo sapiens_hsa050121.61587831
24Oxidative phosphorylation_Homo sapiens_hsa001901.58527000
25Phototransduction_Homo sapiens_hsa047441.56253284
26Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010401.50824022
27Protein export_Homo sapiens_hsa030601.49918379
28Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005631.40093676
29Spliceosome_Homo sapiens_hsa030401.38865294
30Propanoate metabolism_Homo sapiens_hsa006401.37202687
31Huntingtons disease_Homo sapiens_hsa050161.36797826
32Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006011.35081414
33Purine metabolism_Homo sapiens_hsa002301.25881664
34Pyrimidine metabolism_Homo sapiens_hsa002401.22770634
35Lysine degradation_Homo sapiens_hsa003101.20793634
36Vitamin B6 metabolism_Homo sapiens_hsa007501.18426508
37Valine, leucine and isoleucine degradation_Homo sapiens_hsa002801.17442702
38Nicotine addiction_Homo sapiens_hsa050331.15266562
39Circadian rhythm_Homo sapiens_hsa047101.08259449
40Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049320.97557352
41Nucleotide excision repair_Homo sapiens_hsa034200.95150412
42Oocyte meiosis_Homo sapiens_hsa041140.92842643
43Systemic lupus erythematosus_Homo sapiens_hsa053220.88371738
44Taste transduction_Homo sapiens_hsa047420.86666487
45Olfactory transduction_Homo sapiens_hsa047400.85033767
46Citrate cycle (TCA cycle)_Homo sapiens_hsa000200.84370516
47RNA transport_Homo sapiens_hsa030130.84274164
48Alzheimers disease_Homo sapiens_hsa050100.82997858
49Arginine biosynthesis_Homo sapiens_hsa002200.82830407
50Alcoholism_Homo sapiens_hsa050340.80851326
51Basal cell carcinoma_Homo sapiens_hsa052170.80850698
52Progesterone-mediated oocyte maturation_Homo sapiens_hsa049140.79316410
53Colorectal cancer_Homo sapiens_hsa052100.79278253
54Hedgehog signaling pathway_Homo sapiens_hsa043400.75627909
55Fatty acid metabolism_Homo sapiens_hsa012120.71043215
56Cysteine and methionine metabolism_Homo sapiens_hsa002700.70667320
57Peroxisome_Homo sapiens_hsa041460.69003994
58p53 signaling pathway_Homo sapiens_hsa041150.66702426
59Steroid biosynthesis_Homo sapiens_hsa001000.66664967
60Salivary secretion_Homo sapiens_hsa049700.65766878
61Caffeine metabolism_Homo sapiens_hsa002320.63541227
62Glycerolipid metabolism_Homo sapiens_hsa005610.62469473
63Chemical carcinogenesis_Homo sapiens_hsa052040.60425962
64Ubiquitin mediated proteolysis_Homo sapiens_hsa041200.56950175
65Epstein-Barr virus infection_Homo sapiens_hsa051690.52487223
66Primary immunodeficiency_Homo sapiens_hsa053400.51789811
67Wnt signaling pathway_Homo sapiens_hsa043100.51505789
68Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002500.50055717
69Drug metabolism - cytochrome P450_Homo sapiens_hsa009820.50036863
70Linoleic acid metabolism_Homo sapiens_hsa005910.49605486
71Terpenoid backbone biosynthesis_Homo sapiens_hsa009000.49255182
72cAMP signaling pathway_Homo sapiens_hsa040240.46295165
73GABAergic synapse_Homo sapiens_hsa047270.46181556
74Circadian entrainment_Homo sapiens_hsa047130.44400028
75Metabolic pathways_Homo sapiens_hsa011000.44358866
76Calcium signaling pathway_Homo sapiens_hsa040200.43481126
77Arginine and proline metabolism_Homo sapiens_hsa003300.43468891
78Morphine addiction_Homo sapiens_hsa050320.42609714
79Glycerophospholipid metabolism_Homo sapiens_hsa005640.40765889
80Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009800.40269863
81Inflammatory bowel disease (IBD)_Homo sapiens_hsa053210.40036682
82Renin secretion_Homo sapiens_hsa049240.38932015
83Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa009700.38508703
84Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006040.38078768
85Retinol metabolism_Homo sapiens_hsa008300.37992262
86Hippo signaling pathway_Homo sapiens_hsa043900.37486791
87alpha-Linolenic acid metabolism_Homo sapiens_hsa005920.37441496
88Regulation of autophagy_Homo sapiens_hsa041400.37164244
89Steroid hormone biosynthesis_Homo sapiens_hsa001400.36930137
90Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006030.36339355
91beta-Alanine metabolism_Homo sapiens_hsa004100.36171938
92Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049640.36065698
93Cocaine addiction_Homo sapiens_hsa050300.35837443
94Fatty acid degradation_Homo sapiens_hsa000710.32426916
95Glutathione metabolism_Homo sapiens_hsa004800.29230796
96Pyruvate metabolism_Homo sapiens_hsa006200.27464605
97Ether lipid metabolism_Homo sapiens_hsa005650.26382027
98Amphetamine addiction_Homo sapiens_hsa050310.24438819
99Retrograde endocannabinoid signaling_Homo sapiens_hsa047230.22937578
100TGF-beta signaling pathway_Homo sapiens_hsa043500.22227539

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