ARCHS4

Functional Annotation Prediction

Predicted biological processes (GO)

Rank	Gene Set	Z-score
1	microtubule depolymerization (GO:0007019)	4.95562994
2	protein prenylation (GO:0018342)	4.67347125
3	prenylation (GO:0097354)	4.67347125
4	epithelial cilium movement involved in determination of left/right asymmetry (GO:0060287)	4.65939961
5	acrosome reaction (GO:0007340)	4.64519216
6	negative regulation of transcription regulatory region DNA binding (GO:2000678)	4.43735672
7	epithelial to mesenchymal transition involved in endocardial cushion formation (GO:0003198)	4.24662748
8	regulation of mesenchymal cell apoptotic process (GO:2001053)	4.09050685
9	regulation of centriole replication (GO:0046599)	4.08036843
10	cartilage morphogenesis (GO:0060536)	3.98730640
11	positive regulation of mitochondrial membrane permeability involved in apoptotic process (GO:1902110	3.96644828
12	mitochondrial outer membrane permeabilization involved in programmed cell death (GO:1902686)	3.96644828
13	cellular response to nicotine (GO:0071316)	3.93528350
14	regulation of pigment cell differentiation (GO:0050932)	3.77616935
15	microtubule polymerization or depolymerization (GO:0031109)	3.71818051
16	DNA double-strand break processing (GO:0000729)	3.70855766
17	establishment of protein localization to Golgi (GO:0072600)	3.67053703
18	positive regulation of developmental pigmentation (GO:0048087)	3.66480637
19	positive regulation of DNA damage response, signal transduction by p53 class mediator (GO:0043517)	3.66325653
20	DNA integration (GO:0015074)	3.55926096
21	positive regulation of meiosis (GO:0045836)	3.55322421
22	histone H3-K9 methylation (GO:0051567)	3.54728214
23	centriole replication (GO:0007099)	3.52040295
24	protein neddylation (GO:0045116)	3.51094251
25	somite rostral/caudal axis specification (GO:0032525)	3.44925328
26	peptidyl-lysine trimethylation (GO:0018023)	3.42931601
27	fusion of sperm to egg plasma membrane (GO:0007342)	3.42341908
28	musculoskeletal movement (GO:0050881)	3.37778827
29	multicellular organismal movement (GO:0050879)	3.37778827
30	mesenchymal cell proliferation (GO:0010463)	3.34714941
31	positive regulation of meiotic cell cycle (GO:0051446)	3.33894880
32	dopamine transport (GO:0015872)	3.33657360
33	sperm motility (GO:0030317)	3.25937585
34	retinal cone cell development (GO:0046549)	3.25072588
35	DNA demethylation (GO:0080111)	3.22728754
36	positive regulation of signal transduction by p53 class mediator (GO:1901798)	3.20318593
37	rRNA catabolic process (GO:0016075)	3.12763012
38	protein K11-linked deubiquitination (GO:0035871)	3.10702731
39	regulation of cilium movement (GO:0003352)	3.07454959
40	microtubule nucleation (GO:0007020)	3.06535102
41	sensory perception of smell (GO:0007608)	3.02218228
42	behavioral response to nicotine (GO:0035095)	2.99863345
43	protein targeting to Golgi (GO:0000042)	2.96254298
44	histone H2A acetylation (GO:0043968)	2.95526280
45	histone mRNA catabolic process (GO:0071044)	2.95000115
46	definitive hemopoiesis (GO:0060216)	2.94138267
47	L-fucose catabolic process (GO:0042355)	2.91990027
48	fucose catabolic process (GO:0019317)	2.91990027
49	L-fucose metabolic process (GO:0042354)	2.91990027
50	somatic hypermutation of immunoglobulin genes (GO:0016446)	2.91954478
51	somatic diversification of immune receptors via somatic mutation (GO:0002566)	2.91954478
52	retrograde transport, vesicle recycling within Golgi (GO:0000301)	2.88983683
53	histone H3-K9 modification (GO:0061647)	2.86236331
54	cilium or flagellum-dependent cell motility (GO:0001539)	2.85642312
55	peptidyl-lysine methylation (GO:0018022)	2.83434287
56	negative regulation of thymocyte apoptotic process (GO:0070244)	2.81927891
57	cilium assembly (GO:0042384)	2.81205269
58	regulation of chemokine-mediated signaling pathway (GO:0070099)	2.81001445
59	negative regulation of histone methylation (GO:0031061)	2.80691285
60	myelin assembly (GO:0032288)	2.76994420
61	negative regulation of neurotransmitter transport (GO:0051589)	2.76703639
62	forebrain neuron differentiation (GO:0021879)	2.76404398
63	cilium organization (GO:0044782)	2.76290779
64	snRNA transcription (GO:0009301)	2.75012402
65	peptidyl-threonine dephosphorylation (GO:0035970)	2.73411426
66	detection of chemical stimulus involved in sensory perception of smell (GO:0050911)	2.72610464
67	positive regulation of endothelial cell differentiation (GO:0045603)	2.72567046
68	response to pheromone (GO:0019236)	2.72519728
69	histone H3-K4 trimethylation (GO:0080182)	2.69679403
70	double-strand break repair via homologous recombination (GO:0000724)	2.69676961
71	recombinational repair (GO:0000725)	2.69287668
72	neural tube formation (GO:0001841)	2.66756417
73	negative regulation of heart rate (GO:0010459)	2.64676917
74	DNA dealkylation (GO:0035510)	2.63069407
75	signal transduction involved in regulation of gene expression (GO:0023019)	2.57077066
76	sympathetic nervous system development (GO:0048485)	2.55750823
77	multicellular organism reproduction (GO:0032504)	2.53778911
78	RNA destabilization (GO:0050779)	2.53732308
79	detection of chemical stimulus involved in sensory perception of bitter taste (GO:0001580)	2.53433965
80	detection of chemical stimulus involved in sensory perception (GO:0050907)	2.52897336
81	regulation of histone H3-K9 methylation (GO:0051570)	2.52537184
82	negative regulation by host of viral transcription (GO:0043922)	2.51697919
83	plasma membrane fusion (GO:0045026)	2.51478130
84	regulation of transcription regulatory region DNA binding (GO:2000677)	2.51462596
85	ganglion development (GO:0061548)	2.49554905
86	negative regulation of DNA binding (GO:0043392)	2.49083364
87	microtubule anchoring (GO:0034453)	2.48946442
88	regulation of alternative mRNA splicing, via spliceosome (GO:0000381)	2.48595952
89	intra-Golgi vesicle-mediated transport (GO:0006891)	2.48245315
90	epithelial cilium movement (GO:0003351)	2.48026324
91	activation of transmembrane receptor protein tyrosine kinase activity (GO:0007171)	2.47895150
92	embryonic forelimb morphogenesis (GO:0035115)	2.46932313
93	detection of light stimulus involved in sensory perception (GO:0050962)	2.45531996
94	detection of light stimulus involved in visual perception (GO:0050908)	2.45531996
95	adaptation of signaling pathway (GO:0023058)	2.45012831
96	protein polyglutamylation (GO:0018095)	2.44579771
97	lung secretory cell differentiation (GO:0061140)	2.41787280
98	cellular ketone body metabolic process (GO:0046950)	2.41438457
99	positive regulation of oligodendrocyte differentiation (GO:0048714)	2.40321301
100	mRNA splice site selection (GO:0006376)	2.40217467

Predicted upstream transcription factors (ChEA)

Rank	Gene Set	Z-score
1	POU3F2_20337985_ChIP-ChIP_501MEL_Human	3.14991089
2	GBX2_23144817_ChIP-Seq_PC3_Human	2.99092527
3	IGF1R_20145208_ChIP-Seq_DFB_Human	2.92493881
4	FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse	2.91601608
5	VDR_22108803_ChIP-Seq_LS180_Human	2.81298112
6	TAF15_26573619_Chip-Seq_HEK293_Human	2.75893883
7	ZNF274_21170338_ChIP-Seq_K562_Hela	2.60508093
8	GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse	2.36055683
9	EWS_26573619_Chip-Seq_HEK293_Human	2.27567843
10	CTBP1_25329375_ChIP-Seq_LNCAP_Human	2.20703714
11	P300_19829295_ChIP-Seq_ESCs_Human	2.13803289
12	ZFP57_27257070_Chip-Seq_ESCs_Mouse	2.13214407
13	FUS_26573619_Chip-Seq_HEK293_Human	2.07280284
14	CTBP2_25329375_ChIP-Seq_LNCAP_Human	2.06055929
15	CEBPD_23245923_ChIP-Seq_MEFs_Mouse	2.01480709
16	UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human	1.94531919
17	IRF4_20064451_ChIP-Seq_CD4+T_Mouse	1.94095414
18	CBP_20019798_ChIP-Seq_JUKART_Human	1.94095414
19	SMARCD1_25818293_ChIP-Seq_ESCs_Mouse	1.87944774
20	FLI1_27457419_Chip-Seq_LIVER_Mouse	1.86132394
21	STAT3_23295773_ChIP-Seq_U87_Human	1.83340293
22	AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human	1.81488973
23	SMAD4_21799915_ChIP-Seq_A2780_Human	1.80870757
24	ER_23166858_ChIP-Seq_MCF-7_Human	1.76834358
25	MEIS1_26253404_ChIP-Seq_OPTIC_CUPS_Mouse	1.71081410
26	PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human	1.70341714
27	TEAD4_26923725_Chip-Seq_HEMANGIOBLAST_Mouse	1.70226247
28	POU5F1_26923725_Chip-Seq_MESODERM_Mouse	1.70226247
29	SALL1_21062744_ChIP-ChIP_HESCs_Human	1.69189021
30	CTNNB1_24651522_ChIP-Seq_LGR5+_INTESTINAL_STEM_Human	1.57721035
31	EZH2_22144423_ChIP-Seq_EOC_Human	1.57678536
32	AR_25329375_ChIP-Seq_VCAP_Human	1.55802871
33	MYCN_21190229_ChIP-Seq_SHEP-21N_Human	1.54319293
34	PRDM16_22522345_ChIP-ChIP_PALATE_MESENCHYMAL_Mouse	1.51494480
35	TCF4_23295773_ChIP-Seq_U87_Human	1.50076473
36	BCL11B_21912641_ChIP-Seq_STHDH_STRIUM_Mouse	1.49378106
37	OLIG2_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse	1.45425006
38	TP53_16413492_ChIP-PET_HCT116_Human	1.45331453
39	AR_21572438_ChIP-Seq_LNCaP_Human	1.45094872
40	IRF1_19129219_ChIP-ChIP_H3396_Human	1.41867756
41	EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human	1.41652741
42	PCGF2_27294783_Chip-Seq_NPCs_Mouse	1.40870715
43	RUNX2_22187159_ChIP-Seq_PCA_Human	1.39965837
44	TP63_19390658_ChIP-ChIP_HaCaT_Human	1.38725760
45	PRDM14_20953172_ChIP-Seq_ESCs_Human	1.37742788
46	PIAS1_25552417_ChIP-Seq_VCAP_Human	1.37719410
47	SMARCA4_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse	1.36021874
48	HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human	1.35874538
49	NR3C1_21868756_ChIP-Seq_MCF10A_Human	1.35735778
50	POU5F1_16153702_ChIP-ChIP_HESCs_Human	1.35191013
51	SMAD2/3_21741376_ChIP-Seq_EPCs_Human	1.33988896
52	NANOG_19829295_ChIP-Seq_ESCs_Human	1.33374204
53	SOX2_19829295_ChIP-Seq_ESCs_Human	1.33374204
54	TOP2B_26459242_ChIP-Seq_MCF-7_Human	1.33114159
55	RBPJ_22232070_ChIP-Seq_NCS_Mouse	1.31853902
56	SMAD3_21741376_ChIP-Seq_EPCs_Human	1.31458840
57	PCGF2_27294783_Chip-Seq_ESCs_Mouse	1.30764868
58	FLI1_21867929_ChIP-Seq_TH2_Mouse	1.30354522
59	TCF4_22108803_ChIP-Seq_LS180_Human	1.29317841
60	EZH2_27294783_Chip-Seq_NPCs_Mouse	1.28535050
61	TCFCP2L1_18555785_Chip-Seq_ESCs_Mouse	1.27492714
62	MYC_20876797_ChIP-ChIP_MEDULLOBLASTOMA_Human	1.27359498
63	TBL1_22424771_ChIP-Seq_293T_Human	1.27031187
64	E2F4_17652178_ChIP-ChIP_JURKAT_Human	1.24888211
65	SMAD4_21741376_ChIP-Seq_EPCs_Human	1.24806790
66	TEAD4_22529382_ChIP-Seq_TROPHECTODERM_Mouse	1.24600609
67	RNF2_27304074_Chip-Seq_NSC_Mouse	1.23578989
68	NOTCH1_21737748_ChIP-Seq_TLL_Human	1.23248183
69	SUZ12_27294783_Chip-Seq_NPCs_Mouse	1.21870723
70	NANOG_18555785_Chip-Seq_ESCs_Mouse	1.21099079
71	SALL4_22934838_ChIP-ChIP_CD34+_Human	1.20585546
72	FOXA1_21572438_ChIP-Seq_LNCaP_Human	1.20563225
73	CDX2_21402776_ChIP-Seq_INTESTINAL-VILLUS_Mouse	1.19777383
74	TAL1_21186366_ChIP-Seq_BM-HSCs_Mouse	1.19705737
75	BCAT_22108803_ChIP-Seq_LS180_Human	1.18166158
76	CDX2_19796622_ChIP-Seq_MESCs_Mouse	1.16269952
77	NFYA_21822215_ChIP-Seq_K562_Human	1.16175510
78	ETV2_25802403_ChIP-Seq_MESCs_Mouse	1.12946007
79	TAL1_26923725_Chip-Seq_HEMANGIOBLAST_Mouse	1.10523552
80	TCF3/E2A_22897851_ChIP-Seq_JUKARTE6-1_Human	1.10081915
81	SMAD_19615063_ChIP-ChIP_OVARY_Human	1.10009683
82	JUN_21703547_ChIP-Seq_K562_Human	1.09896662
83	AUTS2_25519132_ChIP-Seq_293T-REX_Human	1.09696238
84	NFYB_21822215_ChIP-Seq_K562_Human	1.09596436
85	HTT_18923047_ChIP-ChIP_STHdh_Human	1.08950046
86	EBF1_22473956_ChIP-Seq_BONE_MARROW_Mouse	1.07714461
87	E2F1_18555785_Chip-Seq_ESCs_Mouse	1.07106804
88	CEBPB_26923725_Chip-Seq_MESODERM_Mouse	1.05410789
89	TP53_22573176_ChIP-Seq_HFKS_Human	1.04965775
90	CDX2_22108803_ChIP-Seq_LS180_Human	1.03463006
91	GLI1_17442700_ChIP-ChIP_MESCs_Mouse	1.03221159
92	P53_22387025_ChIP-Seq_ESCs_Mouse	1.03086417
93	KLF5_20875108_ChIP-Seq_MESCs_Mouse	1.01739107
94	LMO2_26923725_Chip-Seq_MACROPHAGESS_Mouse	1.01593740
95	RXR_22108803_ChIP-Seq_LS180_Human	1.00838079
96	SOX2_21211035_ChIP-Seq_LN229_Gbm	1.00818258
97	TAL1_26923725_Chip-Seq_HPCs_Mouse	1.00723253
98	CBX2_27304074_Chip-Seq_ESCs_Mouse	0.99336863
99	ELK1_19687146_ChIP-ChIP_HELA_Human	0.98943212
100	GATA1_22025678_ChIP-Seq_K562_Human	0.98531292

Predicted mouse phenotypes (MGI)

Rank	Gene Set	Z-score
1	MP0000569_abnormal_digit_pigmentation	4.14531096
2	MP0008057_abnormal_DNA_replication	3.21914726
3	MP0008877_abnormal_DNA_methylation	2.66968161
4	MP0004133_heterotaxia	2.47061727
5	MP0001529_abnormal_vocalization	2.36093778
6	MP0002102_abnormal_ear_morphology	2.24947133
7	MP0005464_abnormal_platelet_physiology	2.21220511
8	MP0002938_white_spotting	2.12072472
9	MP0005253_abnormal_eye_physiology	2.10553046
10	MP0002638_abnormal_pupillary_reflex	2.02676901
11	MP0006276_abnormal_autonomic_nervous	1.99347916
12	MP0005499_abnormal_olfactory_system	1.97904745
13	MP0005394_taste/olfaction_phenotype	1.97904745
14	MP0002095_abnormal_skin_pigmentation	1.97613100
15	MP0008058_abnormal_DNA_repair	1.96804804
16	MP0005410_abnormal_fertilization	1.96676426
17	MP0005171_absent_coat_pigmentation	1.96613393
18	MP0003890_abnormal_embryonic-extraembry	1.92764656
19	MP0000383_abnormal_hair_follicle	1.87284732
20	MP0008789_abnormal_olfactory_epithelium	1.73738221
21	MP0005551_abnormal_eye_electrophysiolog	1.72228260
22	MP0008961_abnormal_basal_metabolism	1.69364619
23	MP0000778_abnormal_nervous_system	1.64958953
24	MP0000427_abnormal_hair_cycle	1.62789850
25	MP0000647_abnormal_sebaceous_gland	1.60215046
26	MP0005083_abnormal_biliary_tract	1.59610026
27	MP0005187_abnormal_penis_morphology	1.59443912
28	MP0003937_abnormal_limbs/digits/tail_de	1.57792731
29	MP0003195_calcinosis	1.55521874
30	MP0009697_abnormal_copulation	1.53881473
31	MP0005645_abnormal_hypothalamus_physiol	1.53788130
32	MP0005167_abnormal_blood-brain_barrier	1.51486618
33	MP0003880_abnormal_central_pattern	1.50823735
34	MP0004134_abnormal_chest_morphology	1.50694683
35	MP0006072_abnormal_retinal_apoptosis	1.50242964
36	MP0008995_early_reproductive_senescence	1.46602900
37	MP0000015_abnormal_ear_pigmentation	1.46529346
38	MP0002751_abnormal_autonomic_nervous	1.46319255
39	MP0001984_abnormal_olfaction	1.45596666
40	MP0003136_yellow_coat_color	1.42767015
41	MP0003698_abnormal_male_reproductive	1.41344254
42	MP0004142_abnormal_muscle_tone	1.39534058
43	MP0001968_abnormal_touch/_nociception	1.36957163
44	MP0004215_abnormal_myocardial_fiber	1.33099807
45	MP0003656_abnormal_erythrocyte_physiolo	1.32625186
46	MP0009046_muscle_twitch	1.29113456
47	MP0008872_abnormal_physiological_respon	1.27764905
48	MP0000631_abnormal_neuroendocrine_gland	1.25351517
49	MP0006054_spinal_hemorrhage	1.24966169
50	MP0005386_behavior/neurological_phenoty	1.24867624
51	MP0004924_abnormal_behavior	1.24867624
52	MP0001929_abnormal_gametogenesis	1.21503932
53	MP0004084_abnormal_cardiac_muscle	1.19375405
54	MP0001486_abnormal_startle_reflex	1.19295115
55	MP0001485_abnormal_pinna_reflex	1.18761049
56	MP0003786_premature_aging	1.18561341
57	MP0004043_abnormal_pH_regulation	1.16519353
58	MP0002254_reproductive_system_inflammat	1.13351259
59	MP0001986_abnormal_taste_sensitivity	1.09660476
60	MP0003718_maternal_effect	1.09228329
61	MP0002067_abnormal_sensory_capabilities	1.07946086
62	MP0005391_vision/eye_phenotype	1.07642622
63	MP0005646_abnormal_pituitary_gland	1.07622383
64	MP0000230_abnormal_systemic_arterial	1.04925565
65	MP0003787_abnormal_imprinting	1.00807375
66	MP0008775_abnormal_heart_ventricle	0.96871490
67	MP0001293_anophthalmia	0.96518762
68	MP0010678_abnormal_skin_adnexa	0.96215376
69	MP0002736_abnormal_nociception_after	0.92987007
70	MP0010094_abnormal_chromosome_stability	0.92633474
71	MP0010386_abnormal_urinary_bladder	0.92183573
72	MP0003121_genomic_imprinting	0.89996544
73	MP0006292_abnormal_olfactory_placode	0.89133340
74	MP0003878_abnormal_ear_physiology	0.87223524
75	MP0005377_hearing/vestibular/ear_phenot	0.87223524
76	MP0008932_abnormal_embryonic_tissue	0.86665664
77	MP0000358_abnormal_cell_content/	0.85076882
78	MP0003646_muscle_fatigue	0.84395418
79	MP0002184_abnormal_innervation	0.84383042
80	MP0000013_abnormal_adipose_tissue	0.82505091
81	MP0008007_abnormal_cellular_replicative	0.81735367
82	MP0005310_abnormal_salivary_gland	0.81574481
83	MP0002822_catalepsy	0.80334105
84	MP0005085_abnormal_gallbladder_physiolo	0.79143327
85	MP0003941_abnormal_skin_development	0.76961274
86	MP0005195_abnormal_posterior_eye	0.75535389
87	MP0006035_abnormal_mitochondrial_morpho	0.74606269
88	MP0002210_abnormal_sex_determination	0.74395997
89	MP0004085_abnormal_heartbeat	0.74250177
90	MP0002272_abnormal_nervous_system	0.74247606
91	MP0009745_abnormal_behavioral_response	0.73829318
92	MP0002160_abnormal_reproductive_system	0.73519822
93	MP0002752_abnormal_somatic_nervous	0.73442325
94	MP0000653_abnormal_sex_gland	0.68704550
95	MP0001764_abnormal_homeostasis	0.67677866
96	MP0002177_abnormal_outer_ear	0.66958981
97	MP0005423_abnormal_somatic_nervous	0.66615908
98	MP0010307_abnormal_tumor_latency	0.66211155
99	MP0003077_abnormal_cell_cycle	0.65794125
100	MP0005220_abnormal_exocrine_pancreas	0.65688425

Predicted human phenotypes

Rank	Gene Set	Z-score
1	Concave nail (HP:0001598)	5.30106835
2	Tubulointerstitial nephritis (HP:0001970)	4.04562876
3	Hyperventilation (HP:0002883)	3.72128410
4	Oligodactyly (hands) (HP:0001180)	3.71450512
5	Fair hair (HP:0002286)	3.66967975
6	Renal cortical cysts (HP:0000803)	3.27470412
7	Medial flaring of the eyebrow (HP:0010747)	3.25218883
8	Pancreatic cysts (HP:0001737)	3.18914800
9	Abnormality of the renal medulla (HP:0100957)	3.10247441
10	Papillary thyroid carcinoma (HP:0002895)	3.03644377
11	Nephronophthisis (HP:0000090)	3.02760510
12	Pancreatic fibrosis (HP:0100732)	2.98905447
13	Abnormality of the renal cortex (HP:0011035)	2.89561651
14	Volvulus (HP:0002580)	2.82741737
15	Aplasia/Hypoplasia of the earlobes (HP:0009906)	2.80574290
16	Widely spaced teeth (HP:0000687)	2.64824946
17	Asplenia (HP:0001746)	2.61681331
18	Truncal obesity (HP:0001956)	2.60538261
19	Aplasia/Hypoplasia of the tongue (HP:0010295)	2.55360038
20	Cupped ear (HP:0000378)	2.50313828
21	Generalized hypopigmentation of hair (HP:0011358)	2.49495214
22	Aplasia/Hypoplasia of the spleen (HP:0010451)	2.48596671
23	Genital tract atresia (HP:0001827)	2.48428723
24	Aplasia/Hypoplasia of the tibia (HP:0005772)	2.47813706
25	Septate vagina (HP:0001153)	2.46670554
26	Dyschromatopsia (HP:0007641)	2.45668643
27	Progressive cerebellar ataxia (HP:0002073)	2.45208936
28	Congenital primary aphakia (HP:0007707)	2.40444288
29	Gait imbalance (HP:0002141)	2.33160554
30	True hermaphroditism (HP:0010459)	2.30017265
31	Aplasia/Hypoplasia involving the musculature (HP:0001460)	2.29796024
32	Vaginal atresia (HP:0000148)	2.29672633
33	Prolonged bleeding time (HP:0003010)	2.28269967
34	Aplasia/Hypoplasia involving the carpal bones (HP:0006502)	2.27486572
35	Clumsiness (HP:0002312)	2.25765321
36	Thyroid carcinoma (HP:0002890)	2.23844588
37	Bifid tongue (HP:0010297)	2.20306007
38	Attenuation of retinal blood vessels (HP:0007843)	2.20012182
39	Bony spicule pigmentary retinopathy (HP:0007737)	2.19252116
40	Oligodactyly (HP:0012165)	2.18500940
41	Abnormality of midbrain morphology (HP:0002418)	2.15788074
42	Molar tooth sign on MRI (HP:0002419)	2.15788074
43	Acute myeloid leukemia (HP:0004808)	2.14612063
44	Protruding tongue (HP:0010808)	2.11492573
45	Poor coordination (HP:0002370)	2.08886978
46	Tented upper lip vermilion (HP:0010804)	2.08381552
47	Ridged nail (HP:0001807)	2.06982125
48	Short tibia (HP:0005736)	2.05035709
49	Nephrogenic diabetes insipidus (HP:0009806)	2.03484588
50	Menorrhagia (HP:0000132)	2.01074661
51	Type II lissencephaly (HP:0007260)	2.00271835
52	Broad-based gait (HP:0002136)	1.99225834
53	Congenital hepatic fibrosis (HP:0002612)	1.98522808
54	Genetic anticipation (HP:0003743)	1.96707065
55	Midline defect of the nose (HP:0004122)	1.95210353
56	Abnormality of incisor morphology (HP:0011063)	1.93264380
57	Postaxial foot polydactyly (HP:0001830)	1.92401468
58	Abnormal biliary tract physiology (HP:0012439)	1.91899702
59	Bile duct proliferation (HP:0001408)	1.91899702
60	Increased mean platelet volume (HP:0011877)	1.89003825
61	Poikilocytosis (HP:0004447)	1.87662109
62	3-Methylglutaconic aciduria (HP:0003535)	1.87271761
63	Decreased central vision (HP:0007663)	1.86817046
64	Chronic hepatic failure (HP:0100626)	1.86222652
65	Carpal bone hypoplasia (HP:0001498)	1.85643437
66	Blue irides (HP:0000635)	1.85354368
67	Fibular aplasia (HP:0002990)	1.84680583
68	Absent speech (HP:0001344)	1.83043830
69	Congenital stationary night blindness (HP:0007642)	1.81559349
70	Abolished electroretinogram (ERG) (HP:0000550)	1.80931347
71	Abnormal hair whorl (HP:0010721)	1.76327608
72	Delayed puberty (HP:0000823)	1.75304068
73	Abnormality of the labia minora (HP:0012880)	1.72929923
74	Generalized aminoaciduria (HP:0002909)	1.72456034
75	Aplasia involving forearm bones (HP:0009822)	1.72219368
76	Absent forearm bone (HP:0003953)	1.72219368
77	Postaxial hand polydactyly (HP:0001162)	1.72063075
78	Absent radius (HP:0003974)	1.71561001
79	Intestinal atresia (HP:0011100)	1.70431663
80	Patellar aplasia (HP:0006443)	1.70305313
81	Aplasia/Hypoplasia of the patella (HP:0006498)	1.69608894
82	Chromsome breakage (HP:0040012)	1.69269445
83	Hypoplastic iliac wings (HP:0002866)	1.68835572
84	Exotropia (HP:0000577)	1.68508880
85	Supernumerary bones of the axial skeleton (HP:0009144)	1.68069174
86	Sandal gap (HP:0001852)	1.67581007
87	Large earlobe (HP:0009748)	1.66976808
88	Prominent nasal bridge (HP:0000426)	1.66944047
89	Cutaneous finger syndactyly (HP:0010554)	1.66828132
90	Long clavicles (HP:0000890)	1.66316845
91	Hypoplastic nipples (HP:0002557)	1.64687630
92	Abnormality of chromosome stability (HP:0003220)	1.64686180
93	Aplasia of the musculature (HP:0100854)	1.64561689
94	Drooling (HP:0002307)	1.64239508
95	Hyperlipoproteinemia (HP:0010980)	1.62190759
96	Multicystic kidney dysplasia (HP:0000003)	1.62141060
97	Acanthocytosis (HP:0001927)	1.60899660
98	Lissencephaly (HP:0001339)	1.60758411
99	Rectal fistula (HP:0100590)	1.59588133
100	Rectovaginal fistula (HP:0000143)	1.59588133

Predicted kinase interactions (KEA)

Rank	Gene Set	Z-score
1	MAP4K2	4.62239872
2	FRK	3.58048161
3	AKT3	2.95152965
4	MST4	2.63338500
5	PNCK	2.62003281
6	PLK2	2.60010341
7	ADRBK2	2.36453351
8	BMPR1B	2.36029500
9	PLK4	2.32511434
10	ACVR1B	2.14879594
11	TAOK3	2.11776229
12	TXK	2.11452283
13	BRD4	1.98322423
14	CAMK1G	1.91537627
15	ZAK	1.79115339
16	NUAK1	1.70871431
17	TEC	1.66420831
18	MAP3K4	1.65382975
19	CAMK1D	1.59972530
20	TRIM28	1.53711924
21	SRPK1	1.46479429
22	MAPK13	1.40119769
23	STK38L	1.31563859
24	BRSK2	1.26951386
25	MKNK1	1.25805552
26	PIK3CG	1.24097059
27	CASK	1.22495304
28	MUSK	1.17868865
29	PINK1	1.16256116
30	ADRBK1	1.15594390
31	MKNK2	1.12842162
32	MAP3K6	1.09799977
33	INSRR	1.09629556
34	CDK3	1.04979859
35	PTK2B	1.03105628
36	TLK1	1.02071315
37	BTK	1.01204572
38	GRK1	0.94578057
39	MAP2K7	0.92524970
40	TNIK	0.88126938
41	WNK1	0.87124880
42	VRK1	0.82623975
43	PLK3	0.82574014
44	GRK5	0.80673005
45	CAMKK2	0.78864526
46	CSNK1A1L	0.75889620
47	BCR	0.71241511
48	NTRK3	0.70953040
49	SYK	0.69647565
50	MAP2K4	0.68615665
51	EIF2AK3	0.67732606
52	STK4	0.66444991
53	TSSK6	0.65360901
54	WNK4	0.64466104
55	STK39	0.63834206
56	CDK12	0.63119079
57	ITK	0.62595143
58	OXSR1	0.61023871
59	PRKAA1	0.60912870
60	WNK3	0.60655396
61	CSNK1G1	0.58902788
62	CCNB1	0.58644301
63	EIF2AK1	0.57547611
64	ATR	0.57115856
65	MARK1	0.56839004
66	SGK2	0.56773462
67	RPS6KA5	0.56113660
68	RIPK4	0.55110365
69	CHUK	0.54261428
70	CSNK1G3	0.53568118
71	STK3	0.53239713
72	PLK1	0.52610148
73	WEE1	0.49966960
74	MAP4K1	0.49599975
75	PAK3	0.48671560
76	CHEK2	0.48291304
77	PRKCG	0.47276310
78	CAMK1	0.47162470
79	CAMK4	0.46139946
80	RPS6KA4	0.45872927
81	FLT3	0.44564087
82	GRK6	0.43291405
83	GRK7	0.42974887
84	STK38	0.41309852
85	ATM	0.41309296
86	EPHA4	0.40963517
87	CDK19	0.40911064
88	MAPK15	0.40632623
89	OBSCN	0.40587167
90	DYRK3	0.40364138
91	CSNK1D	0.39647825
92	PRKACB	0.39377011
93	MAP3K5	0.38717730
94	ERBB2	0.38310154
95	NEK9	0.38135326
96	CSNK1G2	0.36800864
97	TGFBR2	0.34890176
98	MELK	0.34865004
99	SGK1	0.33560634
100	PBK	0.32281944

Predicted pathways (KEGG)

Rank	Gene Set	Z-score
1	Non-homologous end-joining_Homo sapiens_hsa03450	3.56016400
2	Olfactory transduction_Homo sapiens_hsa04740	2.97021947
3	Synthesis and degradation of ketone bodies_Homo sapiens_hsa00072	2.71268117
4	Basal transcription factors_Homo sapiens_hsa03022	2.58598407
5	Phototransduction_Homo sapiens_hsa04744	2.45330855
6	Alcoholism_Homo sapiens_hsa05034	2.41546088
7	Systemic lupus erythematosus_Homo sapiens_hsa05322	2.34589068
8	Fanconi anemia pathway_Homo sapiens_hsa03460	2.29398844
9	Terpenoid backbone biosynthesis_Homo sapiens_hsa00900	2.22725374
10	Nicotine addiction_Homo sapiens_hsa05033	2.14510806
11	Butanoate metabolism_Homo sapiens_hsa00650	2.06228185
12	Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa00563	1.95784611
13	Steroid biosynthesis_Homo sapiens_hsa00100	1.88863873
14	Neuroactive ligand-receptor interaction_Homo sapiens_hsa04080	1.86191959
15	Taste transduction_Homo sapiens_hsa04742	1.83071358
16	Nitrogen metabolism_Homo sapiens_hsa00910	1.74303660
17	Platelet activation_Homo sapiens_hsa04611	1.58261416
18	Lysine degradation_Homo sapiens_hsa00310	1.56630445
19	Selenocompound metabolism_Homo sapiens_hsa00450	1.55987061
20	Ubiquitin mediated proteolysis_Homo sapiens_hsa04120	1.52118362
21	Homologous recombination_Homo sapiens_hsa03440	1.45489459
22	Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa00601	1.44749932
23	Morphine addiction_Homo sapiens_hsa05032	1.43825693
24	GABAergic synapse_Homo sapiens_hsa04727	1.39022018
25	Serotonergic synapse_Homo sapiens_hsa04726	1.36469142
26	Retrograde endocannabinoid signaling_Homo sapiens_hsa04723	1.34129564
27	Linoleic acid metabolism_Homo sapiens_hsa00591	1.34082008
28	Taurine and hypotaurine metabolism_Homo sapiens_hsa00430	1.30871632
29	RNA degradation_Homo sapiens_hsa03018	1.26266790
30	RNA polymerase_Homo sapiens_hsa03020	1.25458564
31	Ether lipid metabolism_Homo sapiens_hsa00565	1.22682393
32	Regulation of autophagy_Homo sapiens_hsa04140	1.22627483
33	Ribosome biogenesis in eukaryotes_Homo sapiens_hsa03008	1.22579513
34	Circadian entrainment_Homo sapiens_hsa04713	1.11256850
35	RNA transport_Homo sapiens_hsa03013	1.10779811
36	Type II diabetes mellitus_Homo sapiens_hsa04930	1.06313017
37	Pantothenate and CoA biosynthesis_Homo sapiens_hsa00770	1.05890229
38	Caffeine metabolism_Homo sapiens_hsa00232	1.05156377
39	Cholinergic synapse_Homo sapiens_hsa04725	1.03051475
40	Nicotinate and nicotinamide metabolism_Homo sapiens_hsa00760	1.01900998
41	ABC transporters_Homo sapiens_hsa02010	0.99911272
42	SNARE interactions in vesicular transport_Homo sapiens_hsa04130	0.99906508
43	alpha-Linolenic acid metabolism_Homo sapiens_hsa00592	0.96844852
44	Salivary secretion_Homo sapiens_hsa04970	0.96027195
45	Calcium signaling pathway_Homo sapiens_hsa04020	0.95612629
46	Progesterone-mediated oocyte maturation_Homo sapiens_hsa04914	0.92932978
47	Glutamatergic synapse_Homo sapiens_hsa04724	0.92911655
48	Transcriptional misregulation in cancer_Homo sapiens_hsa05202	0.92042138
49	TGF-beta signaling pathway_Homo sapiens_hsa04350	0.91382145
50	Dorso-ventral axis formation_Homo sapiens_hsa04320	0.91321938
51	Dopaminergic synapse_Homo sapiens_hsa04728	0.90269170
52	Maturity onset diabetes of the young_Homo sapiens_hsa04950	0.89200677
53	Base excision repair_Homo sapiens_hsa03410	0.87779044
54	Purine metabolism_Homo sapiens_hsa00230	0.86234510
55	Circadian rhythm_Homo sapiens_hsa04710	0.85480077
56	Primary bile acid biosynthesis_Homo sapiens_hsa00120	0.78198751
57	mRNA surveillance pathway_Homo sapiens_hsa03015	0.76849357
58	cAMP signaling pathway_Homo sapiens_hsa04024	0.75272560
59	Inositol phosphate metabolism_Homo sapiens_hsa00562	0.72120657
60	Retinol metabolism_Homo sapiens_hsa00830	0.70754451
61	Steroid hormone biosynthesis_Homo sapiens_hsa00140	0.70130781
62	Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa04550	0.68121876
63	Long-term depression_Homo sapiens_hsa04730	0.67637601
64	Cocaine addiction_Homo sapiens_hsa05030	0.66739064
65	Insulin secretion_Homo sapiens_hsa04911	0.66296186
66	Amphetamine addiction_Homo sapiens_hsa05031	0.65229459
67	Spliceosome_Homo sapiens_hsa03040	0.60889751
68	Cell cycle_Homo sapiens_hsa04110	0.59108809
69	Collecting duct acid secretion_Homo sapiens_hsa04966	0.58903736
70	Peroxisome_Homo sapiens_hsa04146	0.58050186
71	Mismatch repair_Homo sapiens_hsa03430	0.55983888
72	Viral carcinogenesis_Homo sapiens_hsa05203	0.54744045
73	Vascular smooth muscle contraction_Homo sapiens_hsa04270	0.54177320
74	Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa00603	0.52818226
75	Nucleotide excision repair_Homo sapiens_hsa03420	0.51977797
76	One carbon pool by folate_Homo sapiens_hsa00670	0.51670061
77	Phosphatidylinositol signaling system_Homo sapiens_hsa04070	0.51619233
78	Glycerolipid metabolism_Homo sapiens_hsa00561	0.50951606
79	Oocyte meiosis_Homo sapiens_hsa04114	0.50633397
80	Gap junction_Homo sapiens_hsa04540	0.48579890
81	Cysteine and methionine metabolism_Homo sapiens_hsa00270	0.48315460
82	Hedgehog signaling pathway_Homo sapiens_hsa04340	0.46603757
83	Primary immunodeficiency_Homo sapiens_hsa05340	0.46373837
84	Intestinal immune network for IgA production_Homo sapiens_hsa04672	0.44966472
85	Arachidonic acid metabolism_Homo sapiens_hsa00590	0.42512380
86	p53 signaling pathway_Homo sapiens_hsa04115	0.42267819
87	Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa00533	0.41071634
88	Pancreatic secretion_Homo sapiens_hsa04972	0.40726627
89	Propanoate metabolism_Homo sapiens_hsa00640	0.40370280
90	Fat digestion and absorption_Homo sapiens_hsa04975	0.40327067
91	Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa00970	0.39999677
92	Jak-STAT signaling pathway_Homo sapiens_hsa04630	0.37936179
93	Tryptophan metabolism_Homo sapiens_hsa00380	0.36676508
94	Cytokine-cytokine receptor interaction_Homo sapiens_hsa04060	0.36122715
95	Prostate cancer_Homo sapiens_hsa05215	0.34290514
96	Aldosterone synthesis and secretion_Homo sapiens_hsa04925	0.33262400
97	Longevity regulating pathway - multiple species_Homo sapiens_hsa04213	0.32647687
98	Choline metabolism in cancer_Homo sapiens_hsa05231	0.31876331
99	Pyrimidine metabolism_Homo sapiens_hsa00240	0.31162338
100	Chemokine signaling pathway_Homo sapiens_hsa04062	0.30630728

HNRNPRP1

Functional Annotation Prediction

Predicted biological processes (GO)

Predicted upstream transcription factors (ChEA)

Predicted mouse phenotypes (MGI)

Predicted human phenotypes

Predicted kinase interactions (KEA)

Predicted pathways (KEGG)

Most similar genes based on co-expression Upload to Enrichr

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