ARCHS4

Functional Annotation Prediction

Predicted biological processes (GO)

Rank	Gene Set	Z-score
1	Golgi transport vesicle coating (GO:0048200)	4.31410008
2	COPI coating of Golgi vesicle (GO:0048205)	4.31410008
3	cytoskeletal anchoring at plasma membrane (GO:0007016)	4.01456464
4	protein localization to endosome (GO:0036010)	3.84724466
5	negative regulation of cell size (GO:0045792)	3.79347544
6	negative regulation of erythrocyte differentiation (GO:0045647)	3.74920440
7	regulation of early endosome to late endosome transport (GO:2000641)	3.50071815
8	regulation of NFAT protein import into nucleus (GO:0051532)	3.42653862
9	regulation of glucose import in response to insulin stimulus (GO:2001273)	3.40317924
10	skin morphogenesis (GO:0043589)	3.39989760
11	adherens junction assembly (GO:0034333)	3.38874465
12	barbed-end actin filament capping (GO:0051016)	3.35815975
13	stress fiber assembly (GO:0043149)	3.32521546
14	focal adhesion assembly (GO:0048041)	3.30507596
15	cell-substrate adherens junction assembly (GO:0007045)	3.30507596
16	maintenance of protein localization in endoplasmic reticulum (GO:0035437)	3.30480330
17	protein retention in ER lumen (GO:0006621)	3.21404777
18	retrograde vesicle-mediated transport, Golgi to ER (GO:0006890)	3.20612194
19	planar cell polarity pathway involved in neural tube closure (GO:0090179)	3.16148123
20	cell-substrate junction assembly (GO:0007044)	3.09653040
21	RNA stabilization (GO:0043489)	3.07679924
22	mRNA stabilization (GO:0048255)	3.07679924
23	epithelial cell differentiation involved in prostate gland development (GO:0060742)	3.07018935
24	pentose-phosphate shunt (GO:0006098)	3.05235902
25	3-UTR-mediated mRNA stabilization (GO:0070935)	2.99922414
26	glucocorticoid receptor signaling pathway (GO:0042921)	2.97424228
27	regulation of establishment of planar polarity involved in neural tube closure (GO:0090178)	2.96126276
28	activation of Rac GTPase activity (GO:0032863)	2.88838102
29	glucose 6-phosphate metabolic process (GO:0051156)	2.88731714
30	response to laminar fluid shear stress (GO:0034616)	2.86519721
31	regulation of mammary gland epithelial cell proliferation (GO:0033599)	2.85672451
32	regulation of nucleobase-containing compound transport (GO:0032239)	2.82428167
33	regulation of histone H3-K27 methylation (GO:0061085)	2.81835854
34	semaphorin-plexin signaling pathway (GO:0071526)	2.79635959
35	maternal placenta development (GO:0001893)	2.75444050
36	DNA unwinding involved in DNA replication (GO:0006268)	2.73613969
37	regulation of RNA export from nucleus (GO:0046831)	2.73505520
38	cortical actin cytoskeleton organization (GO:0030866)	2.71707419
39	embryonic process involved in female pregnancy (GO:0060136)	2.71120453
40	mitotic chromosome condensation (GO:0007076)	2.64594950
41	apoptotic process involved in morphogenesis (GO:0060561)	2.63208680
42	intracellular estrogen receptor signaling pathway (GO:0030520)	2.62963463
43	basement membrane organization (GO:0071711)	2.62615100
44	glucose catabolic process (GO:0006007)	2.62414707
45	activation of signaling protein activity involved in unfolded protein response (GO:0006987)	2.61467298
46	histone H3-K36 demethylation (GO:0070544)	2.60567377
47	positive regulation of cyclin-dependent protein serine/threonine kinase activity involved in G1/S tr	2.60476341
48	corticosteroid receptor signaling pathway (GO:0031958)	2.60018168
49	positive regulation of nuclease activity (GO:0032075)	2.56599647
50	modulation by virus of host morphology or physiology (GO:0019048)	2.55997064
51	insulin-like growth factor receptor signaling pathway (GO:0048009)	2.55233142
52	positive regulation of blood vessel endothelial cell migration (GO:0043536)	2.54535386
53	NADPH regeneration (GO:0006740)	2.53407022
54	cellular response to epidermal growth factor stimulus (GO:0071364)	2.53276966
55	positive regulation of Cdc42 GTPase activity (GO:0043089)	2.52512185
56	spliceosomal tri-snRNP complex assembly (GO:0000244)	2.52441251
57	modulation by symbiont of host cellular process (GO:0044068)	2.52430069
58	hemidesmosome assembly (GO:0031581)	2.51371397
59	pinocytosis (GO:0006907)	2.51169211
60	positive regulation of transcription from RNA polymerase II promoter in response to stress (GO:00360	2.51168097
61	dichotomous subdivision of an epithelial terminal unit (GO:0060600)	2.49596343
62	epithelial cell-cell adhesion (GO:0090136)	2.46899982
63	branching involved in mammary gland duct morphogenesis (GO:0060444)	2.43336664
64	activation of MAPKKK activity (GO:0000185)	2.40983791
65	positive regulation of mitochondrial outer membrane permeabilization involved in apoptotic signaling	2.40910401
66	protein-DNA complex disassembly (GO:0032986)	2.40156732
67	nucleosome disassembly (GO:0006337)	2.40156732
68	protein localization to microtubule (GO:0035372)	2.38517781
69	hypotonic response (GO:0006971)	2.37276011
70	endoplasmic reticulum unfolded protein response (GO:0030968)	2.36867962
71	ER-nucleus signaling pathway (GO:0006984)	2.36354637
72	negative regulation of fatty acid transport (GO:2000192)	2.36262610
73	positive regulation of receptor recycling (GO:0001921)	2.36034922
74	proline biosynthetic process (GO:0006561)	2.35728300
75	activation of JUN kinase activity (GO:0007257)	2.35631186
76	cortical cytoskeleton organization (GO:0030865)	2.35341102
77	regulation of ARF protein signal transduction (GO:0032012)	2.35125655
78	regulation of nuclease activity (GO:0032069)	2.31649631
79	response to epidermal growth factor (GO:0070849)	2.28593228
80	peptidyl-lysine dimethylation (GO:0018027)	2.27425777
81	vesicle coating (GO:0006901)	2.26465701
82	actin filament bundle assembly (GO:0051017)	2.26169046
83	actin filament bundle organization (GO:0061572)	2.26169046
84	regulation of extracellular matrix disassembly (GO:0010715)	2.26073518
85	endothelial cell chemotaxis (GO:0035767)	2.25470700
86	positive regulation of myotube differentiation (GO:0010831)	2.24161810
87	membrane protein ectodomain proteolysis (GO:0006509)	2.24077808
88	embryonic eye morphogenesis (GO:0048048)	2.23306231
89	histone H3-K9 demethylation (GO:0033169)	2.22099957
90	protein targeting to plasma membrane (GO:0072661)	2.21629334
91	regulation of type I interferon-mediated signaling pathway (GO:0060338)	2.20898971
92	vascular endothelial growth factor receptor signaling pathway (GO:0048010)	2.20610370
93	mannose metabolic process (GO:0006013)	2.20503237
94	negative regulation of striated muscle cell differentiation (GO:0051154)	2.19807021
95	positive regulation of protein export from nucleus (GO:0046827)	2.19217160
96	regulation of defense response to virus by virus (GO:0050690)	2.19017971
97	regulation of chromatin binding (GO:0035561)	2.18984823
98	desmosome organization (GO:0002934)	2.18427156
99	apoptotic cell clearance (GO:0043277)	2.17537416
100	regulation of protein insertion into mitochondrial membrane involved in apoptotic signaling pathway	2.16902791

Predicted upstream transcription factors (ChEA)

Rank	Gene Set	Z-score
1	TP63_17297297_ChIP-ChIP_HaCaT_Human	3.60454150
2	NUCKS1_24931609_ChIP-Seq_HEPATOCYTES_Mouse	3.47023755
3	MYC_22102868_ChIP-Seq_BL_Human	3.12403404
4	EGR1_19374776_ChIP-ChIP_THP-1_Human	2.88000657
5	VDR_21846776_ChIP-Seq_THP-1_Human	2.68962336
6	ELK3_25401928_ChIP-Seq_HUVEC_Human	2.54421858
7	LXR_22292898_ChIP-Seq_THP-1_Human	2.48180204
8	KDM2B_26808549_Chip-Seq_SUP-B15_Human	2.45225535
9	NR1H3_23393188_ChIP-Seq_ATHEROSCLEROTIC-FOAM_Human	2.45024089
10	E2F7_22180533_ChIP-Seq_HELA_Human	2.37652903
11	KDM2B_26808549_Chip-Seq_SIL-ALL_Human	2.37421204
12	TCF7_22412390_ChIP-Seq_EML_Mouse	2.30052586
13	THRA_23701648_ChIP-Seq_CEREBELLUM_Mouse	2.24062304
14	RARG_19884340_ChIP-ChIP_MEFs_Mouse	2.17220526
15	RACK7_27058665_Chip-Seq_MCF-7_Human	2.16225201
16	KDM2B_26808549_Chip-Seq_DND41_Human	2.11428765
17	STAT6_21828071_ChIP-Seq_BEAS2B_Human	2.09931418
18	EZH2_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse	2.06012970
19	ZNF263_19887448_ChIP-Seq_K562_Human	1.97426381
20	TBP_23326641_ChIP-Seq_C3H10T1-2_Mouse	1.95439739
21	CLOCK_20551151_ChIP-Seq_293T_Human	1.93624449
22	ZFP281_18757296_ChIP-ChIP_E14_Mouse	1.86320972
23	KDM2B_26808549_Chip-Seq_K562_Human	1.81604988
24	KLF6_26769127_Chip-Seq_PDAC-Cell_line_Human	1.80791456
25	TFAP2C_20629094_ChIP-Seq_MCF-7_Human	1.75071563
26	WT1_20215353_ChIP-ChIP_NEPHRON_PROGENITOR_Mouse	1.73844466
27	PPARG_19300518_ChIP-PET_3T3-L1_Mouse	1.73776175
28	KDM2B_26808549_Chip-Seq_HPB-ALL_Human	1.70296112
29	ESR2_21235772_ChIP-Seq_MCF-7_Human	1.70083443
30	RUNX2_24764292_ChIP-Seq_MC3T3_Mouse	1.69685293
31	ZFP281_18358816_ChIP-ChIP_MESCs_Mouse	1.68654878
32	P300_27058665_Chip-Seq_ZR-75-30cells_Human	1.67981159
33	VDR_24763502_ChIP-Seq_THP-1_Human	1.63920993
34	FOXM1_23109430_ChIP-Seq_U2OS_Human	1.60715360
35	KLF4_26769127_Chip-Seq_PDAC-Cell_line_Human	1.60492641
36	KDM2B_26808549_Chip-Seq_JURKAT_Human	1.58924256
37	EKLF_21900194_ChIP-Seq_ERYTHROCYTE_Mouse	1.58595057
38	TAL1_20566737_ChIP-Seq_PRIMARY_FETAL_LIVER_ERYTHROID_Mouse	1.48773935
39	UBF1/2_26484160_Chip-Seq_HMEC-DERIVED_Human	1.45046255
40	MAF_26560356_Chip-Seq_TH1_Human	1.43571740
41	CREB1_23762244_ChIP-Seq_HIPPOCAMPUS_Rat	1.40827285
42	EGR1_20690147_ChIP-Seq_ERYTHROLEUKEMIA_Human	1.40215254
43	DACH1_20351289_ChIP-Seq_MDA-MB-231_Human	1.39202959
44	ZFP281_27345836_Chip-Seq_ESCs_Mouse	1.32380855
45	CTCF_27219007_Chip-Seq_ERYTHROID_Human	1.30120723
46	TCF21_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human	1.29021264
47	UTX_26944678_Chip-Seq_JUKART_Human	1.28719342
48	TCFAP2C_20176728_ChIP-ChIP_TROPHOBLAST_STEM_CELLS_Mouse	1.28202704
49	MYBL1_21750041_ChIP-ChIP_SPERMATOCYTES_Mouse	1.28154203
50	BRD4_27068464_Chip-Seq_AML-cells_Mouse	1.27915561
51	KLF4_18358816_ChIP-ChIP_MESCs_Mouse	1.27206966
52	VDR_23401126_ChIP-Seq_LCL-AND-THP1_Human	1.26395432
53	DMRT1_23473982_ChIP-Seq_TESTES_Mouse	1.26274892
54	TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat	1.25839168
55	MYB_21317192_ChIP-Seq_ERMYB_Mouse	1.25635209
56	NCOR1_26117541_ChIP-Seq_K562_Human	1.24781654
57	CREB1_20920259_ChIP-Seq_GC1-SPG_Mouse	1.24357085
58	ATF3_27146783_Chip-Seq_COLON_Human	1.23833070
59	CREB1_26743006_Chip-Seq_LNCaP_Human	1.21355399
60	NCOR_22465074_ChIP-Seq_MACROPHAGES_Mouse	1.20780267
61	CREB1_26743006_Chip-Seq_LNCaP-abl_Human	1.20724509
62	CCND1_20090754_ChIP-ChIP_RETINA_Mouse	1.20333734
63	RUNX1_22412390_ChIP-Seq_EML_Mouse	1.20317062
64	RUNX1_27514584_Chip-Seq_MCF-7_Human	1.20245643
65	SMARCA4_20176728_ChIP-ChIP_TSCs_Mouse	1.20181183
66	KLF4_18555785_ChIP-Seq_MESCs_Mouse	1.19020762
67	TRIM28_21343339_ChIP-Seq_HEK293_Human	1.17914152
68	TCF3_18467660_ChIP-ChIP_MESCs_Mouse	1.16575748
69	HIF1A_21447827_ChIP-Seq_MCF-7_Human	1.16151752
70	UBF1/2_26484160_Chip-Seq_HMECs_Human	1.14127531
71	SMC4_20622854_ChIP-Seq_HELA_Human	1.13598196
72	E2A_27217539_Chip-Seq_RAMOS-Cell_line_Human	1.12963089
73	CEBPB_21427703_ChIP-Seq_3T3-L1_Mouse	1.12731323
74	SA1_27219007_Chip-Seq_ERYTHROID_Human	1.11481303
75	SRY_22984422_ChIP-ChIP_TESTIS_Rat	1.11077877
76	TP53_22127205_ChIP-Seq_IMR90_Human	1.10934062
77	GATA1_22383799_ChIP-Seq_G1ME_Mouse	1.10520203
78	TRP63_18441228_ChIP-ChIP_KERATINOCYTES_Mouse	1.10138894
79	ELF3_26769127_Chip-Seq_PDAC-Cell_line_Human	1.10080233
80	GATA1_19941827_ChIP-Seq_MEL_Mouse	1.09991240
81	TET1_21451524_ChIP-Seq_MESCs_Mouse	1.09500534
82	P68_20966046_ChIP-Seq_HELA_Human	1.09130339
83	RELA_24523406_ChIP-Seq_FIBROSARCOMA_Human	1.07080789
84	MECOM_23826213_ChIP-Seq_KASUMI_Mouse	1.05933104
85	DNAJC2_21179169_ChIP-ChIP_NT2_Human	1.05639804
86	ERG_21242973_ChIP-ChIP_JURKAT_Human	1.05634491
87	EP300_20729851_ChIP-Seq_FORBRAIN_MIDBRAIN_LIMB_HEART_Mouse	1.04905313
88	MAF_26560356_Chip-Seq_TH2_Human	1.03605232
89	POU5F1_18700969_ChIP-ChIP_MESCs_Mouse	1.02270743
90	SMRT_22465074_ChIP-Seq_MACROPHAGES_Mouse	1.01591819
91	GATA1_19941826_ChIP-Seq_K562_Human	1.00854508
92	SOX9_24532713_ChIP-Seq_HFSC_Mouse	0.99622525
93	ESR1_15608294_ChIP-ChIP_MCF-7_Human	0.99347829
94	SCL_19346495_ChIP-Seq_HPC-7_Human	0.98884602
95	SOX9_25088423_ChIP-ChIP_EMBRYONIC_GONADS_Mouse	0.97783178
96	HSF1_23293686_ChIP-Seq_STHDH_STRIATAL_Mouse	0.97725746
97	TAF7L_23326641_ChIP-Seq_C3H10T1-2_Mouse	0.97562256
98	NR0B1_18358816_ChIP-ChIP_MESCs_Mouse	0.96900891
99	SOX2_27498859_Chip-Seq_STOMACH_Mouse	0.94358760
100	TBX20_22328084_ChIP-Seq_HEART_Mouse	0.92809942

Predicted mouse phenotypes (MGI)

Rank	Gene Set	Z-score
1	MP0003705_abnormal_hypodermis_morpholog	5.06634663
2	MP0002877_abnormal_melanocyte_morpholog	4.01520242
3	MP0005451_abnormal_body_composition	3.47582399
4	MP0008438_abnormal_cutaneous_collagen	3.30282969
5	MP0010234_abnormal_vibrissa_follicle	3.11293337
6	MP0005076_abnormal_cell_differentiation	2.77575734
7	MP0003566_abnormal_cell_adhesion	2.67857379
8	MP0001849_ear_inflammation	2.41285411
9	MP0004858_abnormal_nervous_system	2.28961722
10	MP0003300_gastrointestinal_ulcer	2.27920141
11	MP0003091_abnormal_cell_migration	2.09973376
12	MP0005257_abnormal_intraocular_pressure	2.06306205
13	MP0004185_abnormal_adipocyte_glucose	2.04758116
14	MP0003303_peritoneal_inflammation	1.90588848
15	MP0005058_abnormal_lysosome_morphology	1.90433254
16	MP0009278_abnormal_bone_marrow	1.86586392
17	MP0003453_abnormal_keratinocyte_physiol	1.85369915
18	MP0005409_darkened_coat_color	1.76910563
19	MP0001348_abnormal_lacrimal_gland	1.74375545
20	MP0002796_impaired_skin_barrier	1.70411539
21	MP0010352_gastrointestinal_tract_polyps	1.69648532
22	MP0004272_abnormal_basement_membrane	1.66297960
23	MP0008260_abnormal_autophagy	1.60877538
24	MP0000678_abnormal_parathyroid_gland	1.57595065
25	MP0002060_abnormal_skin_morphology	1.57325829
26	MP0000537_abnormal_urethra_morphology	1.53332857
27	MP0004947_skin_inflammation	1.53279376
28	MP0004264_abnormal_extraembryonic_tissu	1.51951157
29	MP0000858_altered_metastatic_potential	1.47089624
30	MP0003329_amyloid_beta_deposits	1.42581802
31	MP0001958_emphysema	1.41820822
32	MP0005275_abnormal_skin_tensile	1.40565319
33	MP0005623_abnormal_meninges_morphology	1.35568476
34	MP0004233_abnormal_muscle_weight	1.34418010
35	MP0005501_abnormal_skin_physiology	1.28668454
36	MP0005023_abnormal_wound_healing	1.28166944
37	MP0005666_abnormal_adipose_tissue	1.26841286
38	MP0003191_abnormal_cellular_cholesterol	1.26237097
39	MP0004808_abnormal_hematopoietic_stem	1.25175999
40	MP0003279_aneurysm	1.24421329
41	MP0002089_abnormal_postnatal_growth/wei	1.21724688
42	MP0003436_decreased_susceptibility_to	1.20823052
43	MP0000733_abnormal_muscle_development	1.19351261
44	MP0002396_abnormal_hematopoietic_system	1.18201690
45	MP0000751_myopathy	1.17233300
46	MP0003183_abnormal_peptide_metabolism	1.15793813
47	MP0009840_abnormal_foam_cell	1.13776659
48	MP0001730_embryonic_growth_arrest	1.11089946
49	MP0005621_abnormal_cell_physiology	1.10155431
50	MP0005375_adipose_tissue_phenotype	1.07761989
51	MP0003172_abnormal_lysosome_physiology	1.06061399
52	MP0009672_abnormal_birth_weight	1.05789166
53	MP0002009_preneoplasia	1.04553645
54	MP0002896_abnormal_bone_mineralization	1.01717661
55	MP0000747_muscle_weakness	1.00659369
56	MP0000579_abnormal_nail_morphology	1.00176594
57	MP0003111_abnormal_nucleus_morphology	0.99860246
58	MP0000462_abnormal_digestive_system	0.99160299
59	MP0000350_abnormal_cell_proliferation	0.98743182
60	MP0000767_abnormal_smooth_muscle	0.98285875
61	MP0000003_abnormal_adipose_tissue	0.97860137
62	MP0010630_abnormal_cardiac_muscle	0.96880535
63	MP0003763_abnormal_thymus_physiology	0.96086833
64	MP0002166_altered_tumor_susceptibility	0.94391516
65	MP0001915_intracranial_hemorrhage	0.92729555
66	MP0002998_abnormal_bone_remodeling	0.92613228
67	MP0004087_abnormal_muscle_fiber	0.89249911
68	MP0001216_abnormal_epidermal_layer	0.88908812
69	MP0002086_abnormal_extraembryonic_tissu	0.88507185
70	MP0004510_myositis	0.87964787
71	MP0009931_abnormal_skin_appearance	0.86662115
72	MP0000759_abnormal_skeletal_muscle	0.86300199
73	MP0009053_abnormal_anal_canal	0.84653844
74	MP0005397_hematopoietic_system_phenotyp	0.83358108
75	MP0001545_abnormal_hematopoietic_system	0.83358108
76	MP0003115_abnormal_respiratory_system	0.82910097
77	MP0002080_prenatal_lethality	0.82293434
78	MP0003448_altered_tumor_morphology	0.82271444
79	MP0004782_abnormal_surfactant_physiolog	0.82176141
80	MP0003828_pulmonary_edema	0.81215502
81	MP0005503_abnormal_tendon_morphology	0.80677433
82	MP0002249_abnormal_larynx_morphology	0.80650481
83	MP0000490_abnormal_crypts_of	0.78166350
84	MP0005464_abnormal_platelet_physiology	0.77982461
85	MP0003984_embryonic_growth_retardation	0.76804397
86	MP0000604_amyloidosis	0.76247985
87	MP0000467_abnormal_esophagus_morphology	0.75653108
88	MP0003634_abnormal_glial_cell	0.72846122
89	MP0001672_abnormal_embryogenesis/_devel	0.70006677
90	MP0005380_embryogenesis_phenotype	0.70006677
91	MP0002088_abnormal_embryonic_growth/wei	0.69466778
92	MP0000377_abnormal_hair_follicle	0.69007539
93	MP0006138_congestive_heart_failure	0.68827272
94	MP0005384_cellular_phenotype	0.68107224
95	MP0000627_abnormal_mammary_gland	0.67814136
96	MP0001243_abnormal_dermal_layer	0.66743056
97	MP0003045_fibrosis	0.65193429
98	MP0002098_abnormal_vibrissa_morphology	0.64129714
99	MP0000685_abnormal_immune_system	0.62049632
100	MP0001881_abnormal_mammary_gland	0.60268503

Predicted human phenotypes

Rank	Gene Set	Z-score
1	Protrusio acetabuli (HP:0003179)	3.84822742
2	Hyperacusis (HP:0010780)	3.74183132
3	Premature rupture of membranes (HP:0001788)	3.42575968
4	Cerebral aneurysm (HP:0004944)	2.75377843
5	Obstructive sleep apnea (HP:0002870)	2.66820035
6	Broad face (HP:0000283)	2.60783910
7	Vertebral compression fractures (HP:0002953)	2.60344905
8	Insomnia (HP:0100785)	2.57379364
9	Arterial tortuosity (HP:0005116)	2.55170123
10	Ulnar bowing (HP:0003031)	2.50485344
11	Increased connective tissue (HP:0009025)	2.49038009
12	Vascular tortuosity (HP:0004948)	2.48034637
13	Distal lower limb amyotrophy (HP:0008944)	2.46522689
14	Fragile skin (HP:0001030)	2.41375468
15	Atrophic scars (HP:0001075)	2.38866504
16	Long palpebral fissure (HP:0000637)	2.29502678
17	Achilles tendon contracture (HP:0001771)	2.28853720
18	Shallow orbits (HP:0000586)	2.22840507
19	Bladder diverticulum (HP:0000015)	2.21923220
20	Distal upper limb amyotrophy (HP:0007149)	2.21267003
21	Upper limb amyotrophy (HP:0009129)	2.21267003
22	Flat acetabular roof (HP:0003180)	2.20574836
23	Genu recurvatum (HP:0002816)	2.13936765
24	Distal lower limb muscle weakness (HP:0009053)	2.13359735
25	Increased variability in muscle fiber diameter (HP:0003557)	2.12984833
26	Biconcave vertebral bodies (HP:0004586)	2.12553724
27	Cerebral inclusion bodies (HP:0100314)	2.10961743
28	Wormian bones (HP:0002645)	2.09607804
29	Cellulitis (HP:0100658)	2.08826871
30	Disproportionate tall stature (HP:0001519)	2.07607719
31	Aneurysm (HP:0002617)	2.05751176
32	Centrally nucleated skeletal muscle fibers (HP:0003687)	2.00929113
33	Vertebral arch anomaly (HP:0008438)	2.00810870
34	Asymmetry of the thorax (HP:0001555)	2.00275120
35	Dilatation of the ascending aorta (HP:0005111)	1.99382243
36	Osteolytic defects of the hand bones (HP:0009699)	1.99173810
37	Osteolytic defects of the phalanges of the hand (HP:0009771)	1.99173810
38	Abnormality of the Achilles tendon (HP:0005109)	1.99058977
39	Abnormality of the fingertips (HP:0001211)	1.98715871
40	Abnormality of skeletal muscle fiber size (HP:0012084)	1.97892308
41	Mitral regurgitation (HP:0001653)	1.97243838
42	Back pain (HP:0003418)	1.95456023
43	Mitral valve prolapse (HP:0001634)	1.95366185
44	Thin bony cortex (HP:0002753)	1.94493301
45	Lower limb amyotrophy (HP:0007210)	1.89829791
46	Neonatal short-limb short stature (HP:0008921)	1.89095874
47	Blue sclerae (HP:0000592)	1.88367449
48	Advanced eruption of teeth (HP:0006288)	1.85163548
49	Ankyloglossia (HP:0010296)	1.82738569
50	Aortic dissection (HP:0002647)	1.80345019
51	Aortic aneurysm (HP:0004942)	1.79099344
52	Abnormality of the distal phalanx of the thumb (HP:0009617)	1.78966301
53	Hyperparathyroidism (HP:0000843)	1.78563567
54	Spinal rigidity (HP:0003306)	1.77256743
55	Patellar dislocation (HP:0002999)	1.76953323
56	Exercise-induced myalgia (HP:0003738)	1.76641641
57	Persistence of primary teeth (HP:0006335)	1.76481214
58	Elfin facies (HP:0004428)	1.75809403
59	Short nail (HP:0001799)	1.73728666
60	Renal duplication (HP:0000075)	1.72090895
61	Abnormality of the thoracic spine (HP:0100711)	1.72051837
62	Mildly elevated creatine phosphokinase (HP:0008180)	1.71799689
63	Neurofibrillary tangles (HP:0002185)	1.71780625
64	Ankle contracture (HP:0006466)	1.70575476
65	Natal tooth (HP:0000695)	1.69827578
66	Cervical subluxation (HP:0003308)	1.68617753
67	Hand muscle atrophy (HP:0009130)	1.66863126
68	Turricephaly (HP:0000262)	1.66475251
69	Overriding aorta (HP:0002623)	1.66241673
70	Joint laxity (HP:0001388)	1.65863306
71	Hyperextensible skin (HP:0000974)	1.64294900
72	Abnormality of dentin (HP:0010299)	1.64134551
73	Hemorrhage of the eye (HP:0011885)	1.63831437
74	Dysmetric saccades (HP:0000641)	1.63658181
75	Syringomyelia (HP:0003396)	1.63289022
76	Spinal cord lesions (HP:0100561)	1.63289022
77	Elbow flexion contracture (HP:0002987)	1.62674210
78	Termporal pattern (HP:0011008)	1.62655314
79	Insidious onset (HP:0003587)	1.62655314
80	Difficulty climbing stairs (HP:0003551)	1.62635954
81	Eczematoid dermatitis (HP:0000976)	1.62023127
82	Deep palmar crease (HP:0006191)	1.61900936
83	Abnormality of the distal phalanges of the toes (HP:0010182)	1.61880259
84	Abnormality of oral frenula (HP:0000190)	1.61678993
85	Reticulocytosis (HP:0001923)	1.61446190
86	Bowel diverticulosis (HP:0005222)	1.59337462
87	Hammertoe (HP:0001765)	1.58544343
88	Nuclear cataract (HP:0100018)	1.57197851
89	Germ cell neoplasia (HP:0100728)	1.57190799
90	Cholecystitis (HP:0001082)	1.56518443
91	Abnormal gallbladder physiology (HP:0012438)	1.56518443
92	Cupped ribs (HP:0000887)	1.56502536
93	Precocious puberty (HP:0000826)	1.56282973
94	Renovascular hypertension (HP:0100817)	1.56270025
95	Hypercortisolism (HP:0001578)	1.55136302
96	Emphysema (HP:0002097)	1.54548157
97	Apathy (HP:0000741)	1.53578120
98	Pointed chin (HP:0000307)	1.53286039
99	J-shaped sella turcica (HP:0002680)	1.52532841
100	Flat cornea (HP:0007720)	1.52253728

Predicted kinase interactions (KEA)

Rank	Gene Set	Z-score
1	TRIB3	4.53239012
2	SMG1	3.69019748
3	CDK12	3.46419453
4	EEF2K	3.02240742
5	PRPF4B	2.93796054
6	ERN1	2.92454322
7	ICK	2.56267104
8	SIK1	2.56038841
9	RIPK1	2.20961663
10	IRAK3	2.05598728
11	MAP3K10	1.89689476
12	PDGFRA	1.86998530
13	FGFR4	1.73116553
14	PKN2	1.71251244
15	MAP3K9	1.64170396
16	LATS2	1.63791557
17	TTN	1.61255821
18	MAP3K13	1.59127762
19	SCYL2	1.56701497
20	NTRK1	1.45083775
21	KSR2	1.42218870
22	EPHA2	1.40880408
23	ARAF	1.35551233
24	MOS	1.28754470
25	MTOR	1.22576792
26	MST1R	1.10187856
27	NME2	1.08885171
28	TESK1	1.04929124
29	PAK4	1.01561553
30	MAP3K1	1.00140195
31	TAOK1	0.99772085
32	CAMK1D	0.97439574
33	PTK2	0.97435449
34	EPHB1	0.96107205
35	RIPK4	0.94545934
36	CDC42BPA	0.92215866
37	RPS6KA2	0.90822638
38	PTK6	0.90391049
39	TAOK2	0.89579971
40	TESK2	0.87219146
41	CAMK1G	0.86483544
42	PRKD3	0.86390037
43	SIK2	0.85323174
44	RPS6KB2	0.85231993
45	DDR2	0.84518660
46	MARK2	0.83501676
47	MAP4K1	0.82877917
48	MAP3K14	0.82720583
49	BRD4	0.82076301
50	PRKD2	0.79443193
51	MAP2K3	0.78214294
52	BLK	0.77667104
53	TAF1	0.76465488
54	MAP3K8	0.75601531
55	CDK4	0.75450000
56	LMTK2	0.75312552
57	PDPK1	0.73029672
58	HIPK2	0.71927663
59	CDK9	0.71452123
60	MAP3K3	0.71328335
61	CDK6	0.69862711
62	CDK7	0.67338056
63	PAK2	0.66460421
64	MAP2K2	0.63214092
65	RET	0.61797122
66	JAK3	0.60523258
67	TBK1	0.60449241
68	IRAK4	0.59176240
69	RPS6KC1	0.57523398
70	RPS6KL1	0.57523398
71	TYRO3	0.57418262
72	MAPK11	0.57032448
73	PDGFRB	0.56853990
74	BRAF	0.56392826
75	NEK9	0.54701498
76	MAP3K11	0.54302300
77	LRRK2	0.52883223
78	ALK	0.49248837
79	SIK3	0.48045482
80	STK10	0.47394219
81	IRAK2	0.46303556
82	FGFR3	0.46078768
83	BMX	0.45637850
84	ZAP70	0.43863821
85	CSF1R	0.43683044
86	SGK3	0.43317986
87	PDK1	0.43264556
88	PIM2	0.42562542
89	MET	0.42246946
90	RAF1	0.41796369
91	ROCK2	0.41476724
92	TYK2	0.40389682
93	KSR1	0.39814350
94	MAPKAPK2	0.39118248
95	JAK1	0.38385794
96	CDK8	0.38074095
97	CLK1	0.37391511
98	MAP3K2	0.37374435
99	MELK	0.36882738
100	CDK11A	0.36357189

Predicted pathways (KEGG)

Rank	Gene Set	Z-score
1	Butirosin and neomycin biosynthesis_Homo sapiens_hsa00524	2.90533131
2	Chronic myeloid leukemia_Homo sapiens_hsa05220	2.16266966
3	Acute myeloid leukemia_Homo sapiens_hsa05221	1.88237764
4	Non-small cell lung cancer_Homo sapiens_hsa05223	1.80664455
5	Central carbon metabolism in cancer_Homo sapiens_hsa05230	1.78338475
6	Pancreatic cancer_Homo sapiens_hsa05212	1.73519586
7	Bladder cancer_Homo sapiens_hsa05219	1.73336538
8	Endometrial cancer_Homo sapiens_hsa05213	1.64798480
9	Thyroid cancer_Homo sapiens_hsa05216	1.63730698
10	B cell receptor signaling pathway_Homo sapiens_hsa04662	1.60540698
11	Notch signaling pathway_Homo sapiens_hsa04330	1.57977387
12	Bacterial invasion of epithelial cells_Homo sapiens_hsa05100	1.55938618
13	Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa04961	1.52564024
14	Renal cell carcinoma_Homo sapiens_hsa05211	1.51951419
15	Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate_Homo sapiens_hsa00532	1.51465358
16	Other glycan degradation_Homo sapiens_hsa00511	1.48621549
17	VEGF signaling pathway_Homo sapiens_hsa04370	1.44348803
18	AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa04933	1.44248544
19	Thyroid hormone signaling pathway_Homo sapiens_hsa04919	1.40205265
20	Pentose phosphate pathway_Homo sapiens_hsa00030	1.39267594
21	Prion diseases_Homo sapiens_hsa05020	1.36972518
22	Fc gamma R-mediated phagocytosis_Homo sapiens_hsa04666	1.36174221
23	Neurotrophin signaling pathway_Homo sapiens_hsa04722	1.33762451
24	Focal adhesion_Homo sapiens_hsa04510	1.32505765
25	Adherens junction_Homo sapiens_hsa04520	1.28989666
26	Glioma_Homo sapiens_hsa05214	1.27881687
27	Fructose and mannose metabolism_Homo sapiens_hsa00051	1.24111913
28	ErbB signaling pathway_Homo sapiens_hsa04012	1.24027502
29	MicroRNAs in cancer_Homo sapiens_hsa05206	1.21847586
30	Prostate cancer_Homo sapiens_hsa05215	1.19570707
31	Proteoglycans in cancer_Homo sapiens_hsa05205	1.18924319
32	Amoebiasis_Homo sapiens_hsa05146	1.17656175
33	Small cell lung cancer_Homo sapiens_hsa05222	1.15738102
34	Fc epsilon RI signaling pathway_Homo sapiens_hsa04664	1.15669625
35	mTOR signaling pathway_Homo sapiens_hsa04150	1.13874533
36	Colorectal cancer_Homo sapiens_hsa05210	1.11406990
37	Hepatitis B_Homo sapiens_hsa05161	1.11210865
38	Estrogen signaling pathway_Homo sapiens_hsa04915	1.08999791
39	Insulin signaling pathway_Homo sapiens_hsa04910	1.07527495
40	Leukocyte transendothelial migration_Homo sapiens_hsa04670	1.05290215
41	Osteoclast differentiation_Homo sapiens_hsa04380	1.05265551
42	Apoptosis_Homo sapiens_hsa04210	1.00635258
43	Prolactin signaling pathway_Homo sapiens_hsa04917	0.99540387
44	Longevity regulating pathway - mammal_Homo sapiens_hsa04211	0.97596969
45	Hepatitis C_Homo sapiens_hsa05160	0.96956242
46	Phospholipase D signaling pathway_Homo sapiens_hsa04072	0.96001482
47	Protein processing in endoplasmic reticulum_Homo sapiens_hsa04141	0.95602397
48	Toll-like receptor signaling pathway_Homo sapiens_hsa04620	0.95533870
49	Regulation of lipolysis in adipocytes_Homo sapiens_hsa04923	0.94840480
50	Longevity regulating pathway - multiple species_Homo sapiens_hsa04213	0.94342081
51	ECM-receptor interaction_Homo sapiens_hsa04512	0.94303232
52	AMPK signaling pathway_Homo sapiens_hsa04152	0.93967839
53	GnRH signaling pathway_Homo sapiens_hsa04912	0.89096013
54	Galactose metabolism_Homo sapiens_hsa00052	0.88962743
55	Influenza A_Homo sapiens_hsa05164	0.86055849
56	Long-term potentiation_Homo sapiens_hsa04720	0.85406917
57	Leishmaniasis_Homo sapiens_hsa05140	0.85071080
58	Toxoplasmosis_Homo sapiens_hsa05145	0.84747664
59	Phosphatidylinositol signaling system_Homo sapiens_hsa04070	0.82697186
60	Vasopressin-regulated water reabsorption_Homo sapiens_hsa04962	0.82078357
61	Choline metabolism in cancer_Homo sapiens_hsa05231	0.80854247
62	Viral carcinogenesis_Homo sapiens_hsa05203	0.80353657
63	Shigellosis_Homo sapiens_hsa05131	0.80157266
64	Endocytosis_Homo sapiens_hsa04144	0.78211029
65	Sphingolipid signaling pathway_Homo sapiens_hsa04071	0.78074358
66	Glycosaminoglycan degradation_Homo sapiens_hsa00531	0.77790275
67	HTLV-I infection_Homo sapiens_hsa05166	0.77575337
68	Platelet activation_Homo sapiens_hsa04611	0.77325541
69	Regulation of actin cytoskeleton_Homo sapiens_hsa04810	0.76614540
70	HIF-1 signaling pathway_Homo sapiens_hsa04066	0.76074704
71	Chagas disease (American trypanosomiasis)_Homo sapiens_hsa05142	0.75739186
72	Biosynthesis of amino acids_Homo sapiens_hsa01230	0.75730112
73	Viral myocarditis_Homo sapiens_hsa05416	0.74580234
74	TNF signaling pathway_Homo sapiens_hsa04668	0.74515940
75	Amyotrophic lateral sclerosis (ALS)_Homo sapiens_hsa05014	0.71332885
76	Salmonella infection_Homo sapiens_hsa05132	0.70355320
77	T cell receptor signaling pathway_Homo sapiens_hsa04660	0.69627327
78	Lysine degradation_Homo sapiens_hsa00310	0.69575280
79	Insulin resistance_Homo sapiens_hsa04931	0.68921500
80	Inositol phosphate metabolism_Homo sapiens_hsa00562	0.68080083
81	Measles_Homo sapiens_hsa05162	0.66933371
82	Tuberculosis_Homo sapiens_hsa05152	0.66895105
83	Adipocytokine signaling pathway_Homo sapiens_hsa04920	0.65968808
84	Herpes simplex infection_Homo sapiens_hsa05168	0.65072347
85	Dilated cardiomyopathy_Homo sapiens_hsa05414	0.62399617
86	Gap junction_Homo sapiens_hsa04540	0.62147681
87	Citrate cycle (TCA cycle)_Homo sapiens_hsa00020	0.61932556
88	Melanogenesis_Homo sapiens_hsa04916	0.61603408
89	Rap1 signaling pathway_Homo sapiens_hsa04015	0.61348354
90	Type II diabetes mellitus_Homo sapiens_hsa04930	0.61201475
91	Vibrio cholerae infection_Homo sapiens_hsa05110	0.60332114
92	Pathways in cancer_Homo sapiens_hsa05200	0.59784272
93	Arrhythmogenic right ventricular cardiomyopathy (ARVC)_Homo sapiens_hsa05412	0.59752295
94	Melanoma_Homo sapiens_hsa05218	0.57589625
95	Pathogenic Escherichia coli infection_Homo sapiens_hsa05130	0.55504556
96	Chemokine signaling pathway_Homo sapiens_hsa04062	0.55081289
97	NF-kappa B signaling pathway_Homo sapiens_hsa04064	0.54942291
98	Lysosome_Homo sapiens_hsa04142	0.54696070
99	FoxO signaling pathway_Homo sapiens_hsa04068	0.51960230
100	PI3K-Akt signaling pathway_Homo sapiens_hsa04151	0.48724324

HNRNPUL2-BSCL2

Functional Annotation Prediction

Predicted biological processes (GO)

Predicted upstream transcription factors (ChEA)

Predicted mouse phenotypes (MGI)

Predicted human phenotypes

Predicted kinase interactions (KEA)

Predicted pathways (KEGG)

Most similar genes based on co-expression Upload to Enrichr

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