HNRNPUP1

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: No gene information available for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1negative regulation of gene silencing (GO:0060969)9.57568531
2fatty acid elongation (GO:0030497)8.56082903
3behavioral response to nicotine (GO:0035095)6.03818796
4skeletal muscle tissue regeneration (GO:0043403)5.84344814
5intra-S DNA damage checkpoint (GO:0031573)5.67488853
6membrane tubulation (GO:0097320)5.59308033
7DNA damage response, detection of DNA damage (GO:0042769)5.44630296
8response to pheromone (GO:0019236)5.42181574
9positive regulation of transcription elongation from RNA polymerase II promoter (GO:0032968)5.35475196
10nucleoside diphosphate catabolic process (GO:0009134)5.33845273
11myoblast migration (GO:0051451)5.27959819
12viral transcription (GO:0019083)5.17800511
13ribosomal small subunit biogenesis (GO:0042274)5.11598642
14translational termination (GO:0006415)5.02504246
15positive regulation of cell cycle G2/M phase transition (GO:1902751)4.90371723
16positive regulation of G2/M transition of mitotic cell cycle (GO:0010971)4.90371723
17sequestering of actin monomers (GO:0042989)4.86243532
18heart trabecula morphogenesis (GO:0061384)4.82050561
19regulation of DNA damage checkpoint (GO:2000001)4.77930283
20maturation of SSU-rRNA (GO:0030490)4.51570261
21negative regulation of striated muscle cell apoptotic process (GO:0010664)4.48007332
22inner cell mass cell proliferation (GO:0001833)4.46839115
23regulation of transcription from RNA polymerase II promoter involved in heart development (GO:1901214.37475546
24regulation of gene silencing (GO:0060968)4.30484820
25translational elongation (GO:0006414)4.21655709
26cellular protein complex disassembly (GO:0043624)3.95578529
27macrophage chemotaxis (GO:0048246)3.91215946
28SRP-dependent cotranslational protein targeting to membrane (GO:0006614)3.90365266
29cotranslational protein targeting to membrane (GO:0006613)3.88733914
30long-chain fatty-acyl-CoA biosynthetic process (GO:0035338)3.88649412
31positive regulation of skeletal muscle tissue development (GO:0048643)3.84609381
32protein targeting to ER (GO:0045047)3.82945628
33viral life cycle (GO:0019058)3.78501627
34establishment of protein localization to endoplasmic reticulum (GO:0072599)3.69000278
35nuclear-transcribed mRNA catabolic process, nonsense-mediated decay (GO:0000184)3.67620478
36autophagic vacuole fusion (GO:0000046)3.62684253
37RNA methylation (GO:0001510)3.60635929
38regulation of transcription involved in G1/S transition of mitotic cell cycle (GO:0000083)3.57725493
39ribosomal small subunit assembly (GO:0000028)3.57240074
40response to nitrosative stress (GO:0051409)3.53770627
41protein localization to endoplasmic reticulum (GO:0070972)3.50250508
42microglial cell activation (GO:0001774)3.43156737
43protein complex disassembly (GO:0043241)3.41993994
44trabecula morphogenesis (GO:0061383)3.38772123
45DNA damage response, signal transduction by p53 class mediator resulting in transcription of p21 cla3.36423326
46renal system development (GO:0072001)3.33943626
47fatty-acyl-CoA biosynthetic process (GO:0046949)3.32968132
48regulation of cell proliferation involved in heart morphogenesis (GO:2000136)3.32546543
49phagocytosis, engulfment (GO:0006911)3.31303289
50positive regulation of DNA-templated transcription, elongation (GO:0032786)3.30233012
51macromolecular complex disassembly (GO:0032984)3.29263610
52regulation of G2/M transition of mitotic cell cycle (GO:0010389)3.24605692
53cell proliferation in forebrain (GO:0021846)3.23648787
54regulation of transcription elongation from RNA polymerase II promoter (GO:0034243)3.21527051
55somite development (GO:0061053)3.21464841
56long-chain fatty-acyl-CoA metabolic process (GO:0035336)3.21397992
57negative regulation of G2/M transition of mitotic cell cycle (GO:0010972)3.19736543
58positive regulation of gastrulation (GO:2000543)3.19269204
59regulation of cell cycle checkpoint (GO:1901976)3.18688685
60regulation of cell cycle G2/M phase transition (GO:1902749)3.14170602
61regulation of mesenchymal to epithelial transition involved in metanephros morphogenesis (GO:00033393.11060600
62regulation of striated muscle cell apoptotic process (GO:0010662)3.08609689
63DNA damage response, signal transduction resulting in transcription (GO:0042772)3.04889102
64negative regulation of cell cycle G2/M phase transition (GO:1902750)3.03179760
65mitotic chromosome condensation (GO:0007076)2.99047377
66protein polyglutamylation (GO:0018095)2.98610093
67chromosome condensation (GO:0030261)2.96531395
68response to xenobiotic stimulus (GO:0009410)2.94260393
69mannosylation (GO:0097502)2.92167784
70negative regulation of meiosis (GO:0045835)2.91521738
71cell junction maintenance (GO:0034331)2.86477372
72positive regulation of DNA binding (GO:0043388)2.84822828
73chemokine-mediated signaling pathway (GO:0070098)2.84167196
74cellular response to gamma radiation (GO:0071480)2.83236723
75acyl-CoA biosynthetic process (GO:0071616)2.78889068
76thioester biosynthetic process (GO:0035384)2.78889068
77defense response to Gram-negative bacterium (GO:0050829)2.78583106
78ribonucleoprotein complex biogenesis (GO:0022613)2.78421390
79chromatin remodeling at centromere (GO:0031055)2.77063757
80translational initiation (GO:0006413)2.75701130
81neuron fate specification (GO:0048665)2.74870156
82histone mRNA metabolic process (GO:0008334)2.72757858
83neuron fate determination (GO:0048664)2.72538257
84chaperone-mediated protein transport (GO:0072321)2.72501368
85peptidyl-arginine methylation (GO:0018216)2.72343287
86peptidyl-arginine N-methylation (GO:0035246)2.72343287
87cellular defense response (GO:0006968)2.71163402
88mitochondrial ATP synthesis coupled proton transport (GO:0042776)2.70341219
89nuclear-transcribed mRNA catabolic process (GO:0000956)2.70334440
90regulation of odontogenesis of dentin-containing tooth (GO:0042487)2.67936676
91regulation of heart morphogenesis (GO:2000826)2.65944855
92dopaminergic neuron differentiation (GO:0071542)2.63408175
93spliceosomal tri-snRNP complex assembly (GO:0000244)2.60493921
94fatty-acyl-CoA metabolic process (GO:0035337)2.57994020
95macrophage activation involved in immune response (GO:0002281)2.57741343
96mRNA catabolic process (GO:0006402)2.54625284
97regulation of posttranscriptional gene silencing (GO:0060147)11.6376217
98regulation of gene silencing by miRNA (GO:0060964)11.6376217
99regulation of gene silencing by RNA (GO:0060966)11.6376217
100histone H4-K12 acetylation (GO:0043983)11.0213863

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1EZH2_22144423_ChIP-Seq_EOC_Human5.01441649
2ELF1_17652178_ChIP-ChIP_JURKAT_Human4.82719273
3TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat3.42163464
4CBX2_27304074_Chip-Seq_ESCs_Mouse3.03531151
5E2F7_22180533_ChIP-Seq_HELA_Human2.77892023
6EED_16625203_ChIP-ChIP_MESCs_Mouse2.76099249
7FOXM1_25889361_ChIP-Seq_OE33_AND_U2OS_Human2.55939968
8TAF15_26573619_Chip-Seq_HEK293_Human2.54016000
9EZH2_27304074_Chip-Seq_ESCs_Mouse2.50320437
10GABP_17652178_ChIP-ChIP_JURKAT_Human2.41099110
11SOX9_22984422_ChIP-ChIP_TESTIS_Rat2.32870640
12VDR_22108803_ChIP-Seq_LS180_Human2.31432721
13MYBL2_22936984_ChIP-ChIP_MESCs_Mouse2.26777484
14TDRD3_21172665_ChIP-Seq_MCF-7_Human2.23099606
15CTNNB1_20615089_ChIP-ChIP_FETAL_BRAIN_Human2.22531237
16MYC_18940864_ChIP-ChIP_HL60_Human2.20470068
17JARID2_20064375_ChIP-Seq_MESCs_Mouse2.19427754
18GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse2.18827814
19HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse2.14344655
20BMI1_23680149_ChIP-Seq_NPCS_Mouse2.08809935
21PHC1_16625203_ChIP-ChIP_MESCs_Mouse2.08629354
22RNF2_16625203_ChIP-ChIP_MESCs_Mouse2.04623353
23MYCN_21190229_ChIP-Seq_SHEP-21N_Human1.98198636
24KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human1.96931197
25HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human1.88792038
26SUZ12_16625203_ChIP-ChIP_MESCs_Mouse1.78623360
27CREB1_15753290_ChIP-ChIP_HEK293T_Human1.72506166
28OLIG2_26023283_ChIP-Seq_AINV15_Mouse1.68490484
29FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse1.68395460
30IRF1_19129219_ChIP-ChIP_H3396_Human1.62556037
31CHD1_19587682_ChIP-ChIP_MESCs_Mouse1.59863195
32YY1_21170310_ChIP-Seq_MESCs_Mouse1.58772232
33POU5F1_16153702_ChIP-ChIP_HESCs_Human1.57864471
34EBNA1_20929547_Chip-Seq_RAJI-cells_Human1.56146949
35SOX2_22085726_ChIP-Seq_NPCs_Mouse1.55226454
36EZH2_27294783_Chip-Seq_ESCs_Mouse1.51097535
37TP63_19390658_ChIP-ChIP_HaCaT_Human1.47331303
38FOXM1_23109430_ChIP-Seq_U2OS_Human1.46207731
39RUNX1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.46012130
40CTBP1_25329375_ChIP-Seq_LNCAP_Human1.44943032
41AR_21909140_ChIP-Seq_LNCAP_Human1.44890981
42MYC_18555785_ChIP-Seq_MESCs_Mouse1.44155603
43CBP_20019798_ChIP-Seq_JUKART_Human1.44095792
44IRF4_20064451_ChIP-Seq_CD4+T_Mouse1.44095792
45HCFC1_20581084_ChIP-Seq_MESCs_Mouse1.44013537
46XRN2_22483619_ChIP-Seq_HELA_Human1.43905767
47RNF2_27304074_Chip-Seq_ESCs_Mouse1.43360405
48TP53_20018659_ChIP-ChIP_R1E_Mouse1.40379329
49ETS1_20019798_ChIP-Seq_JURKAT_Human1.39018274
50CDKN2AIP_20523734_ChIP-Seq_CORTICAL_Neurons1.38781689
51ERG_21242973_ChIP-ChIP_JURKAT_Human1.38118537
52ZNF274_21170338_ChIP-Seq_K562_Hela1.32658967
53JARID2_20075857_ChIP-Seq_MESCs_Mouse1.32600663
54RBPJ_21746931_ChIP-Seq_IB4-LCL_Human1.31647387
55RNF2_18974828_ChIP-Seq_MESCs_Mouse1.28240890
56EZH2_18974828_ChIP-Seq_MESCs_Mouse1.28240890
57ELK1_19687146_ChIP-ChIP_HELA_Human1.28078944
58SUZ12_27294783_Chip-Seq_ESCs_Mouse1.25511153
59MYC_19079543_ChIP-ChIP_MESCs_Mouse1.23624554
60E2F4_17652178_ChIP-ChIP_JURKAT_Human1.23347850
61TTF2_22483619_ChIP-Seq_HELA_Human1.22789976
62KLF4_19030024_ChIP-ChIP_MESCs_Mouse1.22238980
63RNF2_27304074_Chip-Seq_NSC_Mouse1.21389848
64HTT_18923047_ChIP-ChIP_STHdh_Human1.20461759
65SUZ12_18555785_ChIP-Seq_MESCs_Mouse1.19569789
66SIN3B_21632747_ChIP-Seq_MESCs_Mouse1.19077245
67CTCF_27219007_Chip-Seq_Bcells_Human1.18732825
68SOX2_16153702_ChIP-ChIP_HESCs_Human1.18140015
69RARB_24833708_ChIP-Seq_LIVER_Mouse1.12641090
70FUS_26573619_Chip-Seq_HEK293_Human1.12152746
71REST_21632747_ChIP-Seq_MESCs_Mouse1.10723739
72TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.10159585
73MYCN_19997598_ChIP-ChIP_NEUROBLASTOMA_Human1.09796917
74EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human1.09506501
75MYC_20876797_ChIP-ChIP_MEDULLOBLASTOMA_Human1.07034972
76FOXP2_21765815_ChIP-ChIP_NEURO2A_Mouse1.04928274
77WDR5_24793694_ChIP-Seq_LNCAP_Human1.03094810
78TCF4_18268006_ChIP-ChIP_LS174T_Human1.02475292
79SOX2_18555785_ChIP-Seq_MESCs_Mouse1.02033213
80E2F1_20622854_ChIP-Seq_HELA_Human1.01995634
81NR4A2_19515692_ChIP-ChIP_MN9D_Mouse1.01804769
82RING1B_27294783_Chip-Seq_NPCs_Mouse1.00456484
83NOTCH1_21737748_ChIP-Seq_TLL_Human0.99097698
84KLF5_20875108_ChIP-Seq_MESCs_Mouse0.98943826
85SUZ12_18692474_ChIP-Seq_MESCs_Mouse0.98293572
86BCL6_27268052_Chip-Seq_Bcells_Human0.98113762
87SUZ12_18974828_ChIP-Seq_MESCs_Mouse0.98009587
88SUZ12_18692474_ChIP-Seq_MEFs_Mouse0.97879249
89MYCN_27167114_Chip-Seq_NEUROBLASTOMA_Human0.96810150
90ERA_21632823_ChIP-Seq_H3396_Human0.95697090
91MYC_18358816_ChIP-ChIP_MESCs_Mouse0.94871632
92EBNA2_21746931_ChIP-Seq_IB4-LCL_Human0.93860486
93YY1_22570637_ChIP-Seq_MALME-3M_Human0.92886388
94EST1_17652178_ChIP-ChIP_JURKAT_Human0.92879733
95AUTS2_25519132_ChIP-Seq_293T-REX_Human0.92149787
96REST_18959480_ChIP-ChIP_MESCs_Mouse0.91178705
97SOX11_23321250_ChIP-ChIP_Z138-A519-JVM2_Human0.90483268
98REST_19997604_ChIP-ChIP_NEURONS_Mouse0.89929441
99SMAD2/3_21741376_ChIP-Seq_ESCs_Human0.88692419
100FLI1_26923725_Chip-Seq_HEMOGENIC-ENDOTHELIUM_Mouse0.88546474

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0009379_abnormal_foot_pigmentation4.75688166
2MP0006292_abnormal_olfactory_placode4.38774592
3MP0001188_hyperpigmentation3.68712143
4MP0003567_abnormal_fetal_cardiomyocyte3.15152581
5MP0003011_delayed_dark_adaptation2.78024516
6MP0004185_abnormal_adipocyte_glucose2.72110968
7MP0006082_CNS_inflammation2.58416475
8MP0008789_abnormal_olfactory_epithelium2.41781053
9MP0004142_abnormal_muscle_tone2.36401676
10MP0000750_abnormal_muscle_regeneration2.30924814
11MP0001293_anophthalmia2.24791614
12MP0000685_abnormal_immune_system2.10378373
13MP0008260_abnormal_autophagy2.04069267
14MP0003283_abnormal_digestive_organ2.01167947
15MP0000049_abnormal_middle_ear1.99859304
16MP0000566_synostosis1.98807444
17MP0001915_intracranial_hemorrhage1.92479351
18MP0005671_abnormal_response_to1.91289719
19MP0000631_abnormal_neuroendocrine_gland1.81825686
20MP0004885_abnormal_endolymph1.78915363
21MP0003646_muscle_fatigue1.78727668
22MP0004883_abnormal_blood_vessel1.73356141
23MP0000383_abnormal_hair_follicle1.71431858
24MP0005499_abnormal_olfactory_system1.70774536
25MP0005394_taste/olfaction_phenotype1.70774536
26MP0004019_abnormal_vitamin_homeostasis1.68576081
27MP0001485_abnormal_pinna_reflex1.59727648
28MP0003787_abnormal_imprinting1.56555318
29MP0000026_abnormal_inner_ear1.55573798
30MP0000372_irregular_coat_pigmentation1.54160945
31MP0005171_absent_coat_pigmentation1.53392662
32MP0005551_abnormal_eye_electrophysiolog1.48307076
33MP0002234_abnormal_pharynx_morphology1.47990287
34MP0003936_abnormal_reproductive_system1.42749444
35MP0002928_abnormal_bile_duct1.41638672
36MP0002697_abnormal_eye_size1.37430019
37MP0000534_abnormal_ureter_morphology1.36748746
38MP0001905_abnormal_dopamine_level1.36279444
39MP0005195_abnormal_posterior_eye1.34159721
40MP0002138_abnormal_hepatobiliary_system1.32554556
41MP0002736_abnormal_nociception_after1.32263518
42MP0002638_abnormal_pupillary_reflex1.31798618
43MP0009053_abnormal_anal_canal1.30293714
44MP0002938_white_spotting1.30183252
45MP0010030_abnormal_orbit_morphology1.28392535
46MP0002184_abnormal_innervation1.27496627
47MP0003880_abnormal_central_pattern1.17930683
48MP0000778_abnormal_nervous_system1.16797539
49MP0002653_abnormal_ependyma_morphology1.16751364
50MP0003938_abnormal_ear_development1.15638087
51MP0004742_abnormal_vestibular_system1.15500401
52MP0009333_abnormal_splenocyte_physiolog1.14906232
53MP0005423_abnormal_somatic_nervous1.12480591
54MP0003890_abnormal_embryonic-extraembry1.10645304
55MP0003122_maternal_imprinting1.08676495
56MP0005448_abnormal_energy_balance1.06047669
57MP0003755_abnormal_palate_morphology1.06037161
58MP0003942_abnormal_urinary_system1.05705643
59MP0001286_abnormal_eye_development1.05561867
60MP0002116_abnormal_craniofacial_bone1.03268967
61MP0002210_abnormal_sex_determination0.99259826
62MP0002233_abnormal_nose_morphology0.95527827
63MP0000427_abnormal_hair_cycle0.93481392
64MP0002098_abnormal_vibrissa_morphology0.93350172
65MP0003121_genomic_imprinting0.93349964
66MP0002277_abnormal_respiratory_mucosa0.92882243
67MP0004957_abnormal_blastocyst_morpholog0.91938241
68MP0005197_abnormal_uvea_morphology0.91058192
69MP0000955_abnormal_spinal_cord0.90818533
70MP0003119_abnormal_digestive_system0.90042028
71MP0004130_abnormal_muscle_cell0.89313546
72MP0002751_abnormal_autonomic_nervous0.88074164
73MP0001929_abnormal_gametogenesis0.87235823
74MP0002163_abnormal_gland_morphology0.84701704
75MP0005391_vision/eye_phenotype0.83246452
76MP0003937_abnormal_limbs/digits/tail_de0.83138638
77MP0002102_abnormal_ear_morphology0.80424351
78MP0001324_abnormal_eye_pigmentation0.79815936
79MP0001727_abnormal_embryo_implantation0.78202828
80MP0005166_decreased_susceptibility_to0.78113411
81MP0006072_abnormal_retinal_apoptosis0.76828352
82MP0001243_abnormal_dermal_layer0.75623834
83MP0001145_abnormal_male_reproductive0.75448790
84MP0004133_heterotaxia0.74332000
85MP0002160_abnormal_reproductive_system0.72443345
86MP0002092_abnormal_eye_morphology0.72176296
87MP0002876_abnormal_thyroid_physiology0.71594508
88MP0002971_abnormal_brown_adipose0.71591876
89MP0000653_abnormal_sex_gland0.70259652
90MP0005410_abnormal_fertilization0.69463459
91MP0003315_abnormal_perineum_morphology0.68936564
92MP0001963_abnormal_hearing_physiology0.68658641
93MP0004858_abnormal_nervous_system0.68392283
94MP0002752_abnormal_somatic_nervous0.67715055
95MP0000569_abnormal_digit_pigmentation0.67656147
96MP0008877_abnormal_DNA_methylation0.65025276
97MP0003698_abnormal_male_reproductive0.64992168
98MP0004811_abnormal_neuron_physiology0.64907710
99MP0005389_reproductive_system_phenotype0.63763635
100MP0010678_abnormal_skin_adnexa0.63443533

Predicted human phenotypes

RankGene SetZ-score
1Severe visual impairment (HP:0001141)7.47507278
2Cortical dysplasia (HP:0002539)5.07137217
3Deep palmar crease (HP:0006191)4.60092200
4Congenital stationary night blindness (HP:0007642)4.21736543
5Scotoma (HP:0000575)4.14237121
6Epidermoid cyst (HP:0200040)3.89880661
7Submucous cleft hard palate (HP:0000176)3.87400592
8Hyperlipoproteinemia (HP:0010980)3.73551118
9Abnormality of cells of the erythroid lineage (HP:0012130)3.70373414
10Impulsivity (HP:0100710)3.54717883
11Type 2 muscle fiber atrophy (HP:0003554)3.28819402
12Abnormal rod and cone electroretinograms (HP:0008323)3.22318890
13Bony spicule pigmentary retinopathy (HP:0007737)3.19152229
14Abnormal number of erythroid precursors (HP:0012131)3.13165854
15Pachygyria (HP:0001302)3.12696536
16Nephronophthisis (HP:0000090)3.02927223
17Muscle fiber atrophy (HP:0100295)2.94234308
18Flat capital femoral epiphysis (HP:0003370)2.92563872
19True hermaphroditism (HP:0010459)2.85771221
20Type II lissencephaly (HP:0007260)2.85501641
21Reticulocytopenia (HP:0001896)2.84866609
22Septo-optic dysplasia (HP:0100842)2.76276138
23Central scotoma (HP:0000603)2.71923160
24Aplasia/Hypoplasia of the optic nerve (HP:0008058)2.70607558
253-Methylglutaconic aciduria (HP:0003535)2.67661168
26Bulbous nose (HP:0000414)2.67139432
27Oligomenorrhea (HP:0000876)2.66234127
28Cerebellar dysplasia (HP:0007033)2.58069795
29Abnormality of the aortic arch (HP:0012303)2.56765836
30Maternal diabetes (HP:0009800)2.53568842
31Rib fusion (HP:0000902)2.53356529
32Congenital, generalized hypertrichosis (HP:0004540)2.53248191
33Polymicrogyria (HP:0002126)2.45311719
34Decreased electroretinogram (ERG) amplitude (HP:0000654)2.43249202
35Asplenia (HP:0001746)2.35311946
36Pancreatic fibrosis (HP:0100732)2.32883100
37Hypoplastic pelvis (HP:0008839)2.31124415
38Aplasia/Hypoplasia of the spleen (HP:0010451)2.30715565
39Abnormal number of incisors (HP:0011064)2.29617912
40Macrocytic anemia (HP:0001972)2.27419583
41Abnormality of the antihelix (HP:0009738)2.22135095
42Curly hair (HP:0002212)2.21662053
43Alveolar cell carcinoma (HP:0006519)2.19279227
44Lissencephaly (HP:0001339)2.17853864
45Abnormality of midbrain morphology (HP:0002418)2.16364945
46Molar tooth sign on MRI (HP:0002419)2.16364945
47Spinal cord lesions (HP:0100561)2.14602999
48Syringomyelia (HP:0003396)2.14602999
49Short femoral neck (HP:0100864)2.14078050
50Abnormality of the renal medulla (HP:0100957)2.13797559
51Adrenal hypoplasia (HP:0000835)2.13349302
52Neoplasm of the tracheobronchial system (HP:0100552)2.12297979
53Xanthomatosis (HP:0000991)2.11798769
54Abnormality of the epiphysis of the femoral head (HP:0010574)2.10953918
55Flared iliac wings (HP:0002869)2.10399358
56Progressive microcephaly (HP:0000253)2.08919561
57Respiratory insufficiency due to defective ciliary clearance (HP:0200073)2.08108633
58Absent rod-and cone-mediated responses on ERG (HP:0007688)2.00579454
59Poor coordination (HP:0002370)2.00349079
60Oligodactyly (hands) (HP:0001180)1.98947899
61Medial flaring of the eyebrow (HP:0010747)1.98710890
62Depressed nasal ridge (HP:0000457)1.98413630
63Palpebral edema (HP:0100540)1.98044180
64Microvesicular hepatic steatosis (HP:0001414)1.93953604
65Sparse lateral eyebrow (HP:0005338)1.93077771
66Abnormality of macular pigmentation (HP:0008002)1.93024357
67Nephrogenic diabetes insipidus (HP:0009806)1.91308609
68Pendular nystagmus (HP:0012043)1.90838238
69Abnormality of femoral epiphyses (HP:0006499)1.90089859
70Abnormality involving the epiphyses of the lower limbs (HP:0006500)1.90089859
71Abnormality of hair growth rate (HP:0011363)1.89654176
72Slow-growing hair (HP:0002217)1.89654176
73Postaxial foot polydactyly (HP:0001830)1.88135748
74Abnormality of the phalanges of the hallux (HP:0010057)1.85891316
75Self-mutilation (HP:0000742)1.85626835
76Skin nodule (HP:0200036)1.85526968
77Esophageal atresia (HP:0002032)1.85404803
78Hypoplasia of the radius (HP:0002984)1.82691233
79Abnormal sex determination (HP:0012244)1.82411227
80Sex reversal (HP:0012245)1.82411227
81Arthropathy (HP:0003040)1.82169721
82Type I transferrin isoform profile (HP:0003642)1.80450056
83Congenital primary aphakia (HP:0007707)1.79209163
84Poor head control (HP:0002421)1.78122208
85Abnormal respiratory motile cilium physiology (HP:0012261)1.75726146
86Abnormality of the femoral head (HP:0003368)1.75211235
87Aplasia/Hypoplasia involving the femoral head and neck (HP:0009108)1.75154176
88Abnormality of the renal cortex (HP:0011035)1.74982839
89Abnormality of small intestinal villus morphology (HP:0011472)1.74292011
90Villous atrophy (HP:0011473)1.74292011
91Gait imbalance (HP:0002141)1.74127525
92Anterior segment dysgenesis (HP:0007700)1.73862628
93Aplasia/Hypoplasia affecting the fundus (HP:0008057)1.73708236
94Constricted visual fields (HP:0001133)1.73556431
95Large for gestational age (HP:0001520)1.72208828
96Shawl scrotum (HP:0000049)1.72146523
97Severe muscular hypotonia (HP:0006829)1.72097309
98Pallor (HP:0000980)1.71463782
99Sloping forehead (HP:0000340)1.70544883
100Absent eyebrow (HP:0002223)1.69846222

Predicted kinase interactions (KEA)

RankGene SetZ-score
1TAF17.60913253
2AKT36.85785606
3IRAK45.91376471
4MARK33.18638015
5BRAF2.72815960
6KSR12.49633646
7ILK2.48144210
8PIK3CG2.39813446
9CDC71.91786778
10TESK21.85172166
11ZAK1.75204214
12VRK21.75059669
13PTK21.57707272
14RIPK11.46436696
15NEK11.38341592
16SGK21.32482962
17TLK11.30421101
18MAP3K111.27096458
19PASK1.26311018
20DYRK31.21813210
21LRRK21.21190045
22GRK11.19227587
23DYRK21.10630564
24PRKCI1.10382315
25SGK4941.05486046
26SGK2231.05486046
27MKNK20.99271528
28PINK10.98533333
29VRK10.98210625
30BUB10.97119363
31PIK3CA0.93932278
32UHMK10.89741728
33NEK20.87309094
34BMPR1B0.86415543
35PIM10.82059157
36PLK20.80582824
37BRSK20.80078656
38STK110.79535133
39PLK40.77037935
40MKNK10.76604394
41MAPKAPK30.75310067
42MAP3K90.70248855
43CAMK2B0.69389248
44AURKB0.67398588
45CAMK40.66764145
46ERN10.64527315
47SGK30.64470007
48TGFBR10.64196574
49MAP2K30.61460329
50MAPK130.60657421
51CHEK10.58651869
52PRKCZ0.56154234
53CAMK1D0.55525736
54CHUK0.54742232
55INSRR0.52965477
56ADRBK20.52242206
57MAP2K40.51975667
58TIE10.51657918
59CDK90.50979664
60PLK10.49447525
61EPHB10.49055068
62HIPK20.47670995
63EPHB20.47437897
64CSNK2A20.43394996
65ABL20.43250202
66BTK0.43127818
67MAP2K60.42260659
68CSNK1E0.41703697
69KIT0.41094039
70EPHA40.41020732
71AURKA0.39455217
72STK160.39152446
73ALK0.38966589
74CDK190.38873404
75MAPK150.38514190
76CSF1R0.38380541
77ERBB40.36185473
78MAP4K20.34156516
79WNK30.33250865
80DAPK10.32908487
81NLK0.30829790
82CAMK1G0.29065466
83PRKACA0.29027473
84FRK0.27503756
85STK40.26057468
86CSNK2A10.24457968
87RPS6KA40.24101469
88TAOK30.23889055
89PNCK0.23797655
90IRAK10.23663380
91WEE10.23084616
92TSSK60.22948954
93CDK11A0.22381625
94WNK40.22139109
95CDK150.21947153
96CDK40.21289495
97CAMK2D0.21285731
98PAK10.21073874
99RPS6KA50.20872282
100CDK20.20691942

Predicted pathways (KEGG)

RankGene SetZ-score
1Ribosome_Homo sapiens_hsa030105.94551033
2Fatty acid elongation_Homo sapiens_hsa000625.14209420
3Synthesis and degradation of ketone bodies_Homo sapiens_hsa000724.31630026
4Steroid biosynthesis_Homo sapiens_hsa001003.25906419
5Butanoate metabolism_Homo sapiens_hsa006503.14863698
6Spliceosome_Homo sapiens_hsa030402.44895236
7Parkinsons disease_Homo sapiens_hsa050122.39636443
8Phototransduction_Homo sapiens_hsa047442.24301835
9Oxidative phosphorylation_Homo sapiens_hsa001902.13386508
10Systemic lupus erythematosus_Homo sapiens_hsa053222.08624263
11Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001301.94362625
12Maturity onset diabetes of the young_Homo sapiens_hsa049501.78028266
13Notch signaling pathway_Homo sapiens_hsa043301.72966842
14Hedgehog signaling pathway_Homo sapiens_hsa043401.72198647
15Alcoholism_Homo sapiens_hsa050341.64876339
16Basal cell carcinoma_Homo sapiens_hsa052171.63792937
17Terpenoid backbone biosynthesis_Homo sapiens_hsa009001.63733960
18Cardiac muscle contraction_Homo sapiens_hsa042601.56753218
19Huntingtons disease_Homo sapiens_hsa050161.55789498
20Regulation of autophagy_Homo sapiens_hsa041401.52388758
21Fanconi anemia pathway_Homo sapiens_hsa034601.47243902
22Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030081.45975964
23Pyrimidine metabolism_Homo sapiens_hsa002401.45380394
24Thyroid cancer_Homo sapiens_hsa052161.43573554
25Mismatch repair_Homo sapiens_hsa034301.41037069
26RNA degradation_Homo sapiens_hsa030181.36366121
27Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006011.29676815
28Alzheimers disease_Homo sapiens_hsa050101.18997404
29Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049321.14054385
30Proteasome_Homo sapiens_hsa030501.08909336
31RNA polymerase_Homo sapiens_hsa030201.08572826
32Basal transcription factors_Homo sapiens_hsa030221.07568779
33Neuroactive ligand-receptor interaction_Homo sapiens_hsa040800.99909154
34One carbon pool by folate_Homo sapiens_hsa006700.96807200
35Homologous recombination_Homo sapiens_hsa034400.89284388
36Olfactory transduction_Homo sapiens_hsa047400.88231039
37Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009800.86806119
38Chemical carcinogenesis_Homo sapiens_hsa052040.82873102
39Other types of O-glycan biosynthesis_Homo sapiens_hsa005140.80543661
40Wnt signaling pathway_Homo sapiens_hsa043100.79902274
41Protein export_Homo sapiens_hsa030600.78781161
42Cytokine-cytokine receptor interaction_Homo sapiens_hsa040600.75900346
43Sulfur relay system_Homo sapiens_hsa041220.75612586
44Fat digestion and absorption_Homo sapiens_hsa049750.73231560
45Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa045500.72458990
46Purine metabolism_Homo sapiens_hsa002300.72446918
47RNA transport_Homo sapiens_hsa030130.70449321
48Chemokine signaling pathway_Homo sapiens_hsa040620.69646480
49Drug metabolism - cytochrome P450_Homo sapiens_hsa009820.69181516
50Folate biosynthesis_Homo sapiens_hsa007900.68622753
51Glutathione metabolism_Homo sapiens_hsa004800.66723855
52Melanoma_Homo sapiens_hsa052180.63498867
53Ascorbate and aldarate metabolism_Homo sapiens_hsa000530.63411356
54Dorso-ventral axis formation_Homo sapiens_hsa043200.61321375
55Melanogenesis_Homo sapiens_hsa049160.59308099
56Hippo signaling pathway_Homo sapiens_hsa043900.57132999
57Gap junction_Homo sapiens_hsa045400.54576828
58Graft-versus-host disease_Homo sapiens_hsa053320.53443550
59DNA replication_Homo sapiens_hsa030300.52918674
60Retinol metabolism_Homo sapiens_hsa008300.52873484
61Tyrosine metabolism_Homo sapiens_hsa003500.49947915
62Nitrogen metabolism_Homo sapiens_hsa009100.47748701
63Ubiquitin mediated proteolysis_Homo sapiens_hsa041200.46589932
64Colorectal cancer_Homo sapiens_hsa052100.46048675
65Glioma_Homo sapiens_hsa052140.44413912
66Non-small cell lung cancer_Homo sapiens_hsa052230.41714897
67Primary bile acid biosynthesis_Homo sapiens_hsa001200.41202973
68Neurotrophin signaling pathway_Homo sapiens_hsa047220.40639306
69Transcriptional misregulation in cancer_Homo sapiens_hsa052020.39613208
70Intestinal immune network for IgA production_Homo sapiens_hsa046720.39488208
71Axon guidance_Homo sapiens_hsa043600.39475225
72Longevity regulating pathway - multiple species_Homo sapiens_hsa042130.38392645
73p53 signaling pathway_Homo sapiens_hsa041150.37539895
74Tryptophan metabolism_Homo sapiens_hsa003800.34915252
75Leishmaniasis_Homo sapiens_hsa051400.33227242
76Cocaine addiction_Homo sapiens_hsa050300.33222009
77Serotonergic synapse_Homo sapiens_hsa047260.32027437
78NF-kappa B signaling pathway_Homo sapiens_hsa040640.30248541
79Linoleic acid metabolism_Homo sapiens_hsa005910.28214337
80Prolactin signaling pathway_Homo sapiens_hsa049170.27483823
81Glycine, serine and threonine metabolism_Homo sapiens_hsa002600.27354261
82FoxO signaling pathway_Homo sapiens_hsa040680.25574886
83Endometrial cancer_Homo sapiens_hsa052130.25378014
84Epstein-Barr virus infection_Homo sapiens_hsa051690.25121522
85Pertussis_Homo sapiens_hsa051330.24719036
86ErbB signaling pathway_Homo sapiens_hsa040120.24483583
87Oocyte meiosis_Homo sapiens_hsa041140.23047830
88mRNA surveillance pathway_Homo sapiens_hsa030150.22616297
89Chagas disease (American trypanosomiasis)_Homo sapiens_hsa051420.22109994
90Prostate cancer_Homo sapiens_hsa052150.21754427
91Type I diabetes mellitus_Homo sapiens_hsa049400.19199436
92Adrenergic signaling in cardiomyocytes_Homo sapiens_hsa042610.17927647
93Natural killer cell mediated cytotoxicity_Homo sapiens_hsa046500.16819415
94Morphine addiction_Homo sapiens_hsa050320.16300755
95Renal cell carcinoma_Homo sapiens_hsa052110.15285742
96Metabolic pathways_Homo sapiens_hsa011000.15229813
97Nicotine addiction_Homo sapiens_hsa050330.14716471
98Small cell lung cancer_Homo sapiens_hsa052220.13130542
99cAMP signaling pathway_Homo sapiens_hsa040240.12812103
100Phenylalanine metabolism_Homo sapiens_hsa003600.11909607

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