HOMER1

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: This gene encodes a member of the homer family of dendritic proteins. Members of this family regulate group 1 metabotrophic glutamate receptor function. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1regulation of short-term neuronal synaptic plasticity (GO:0048172)5.69172822
2positive regulation of excitatory postsynaptic membrane potential (GO:2000463)5.64078001
3regulation of alpha-amino-3-hydroxy-5-methyl-4-isoxazole propionate selective glutamate receptor act5.49828897
4vocalization behavior (GO:0071625)5.32597282
5ionotropic glutamate receptor signaling pathway (GO:0035235)5.14133117
6synaptic vesicle exocytosis (GO:0016079)5.09295575
7glutamate secretion (GO:0014047)5.07824810
8locomotory exploration behavior (GO:0035641)5.03881848
9regulation of glutamate receptor signaling pathway (GO:1900449)4.99805690
10synaptic vesicle docking involved in exocytosis (GO:0016081)4.89141759
11neuron cell-cell adhesion (GO:0007158)4.84146727
12regulation of N-methyl-D-aspartate selective glutamate receptor activity (GO:2000310)4.75772887
13neuronal action potential propagation (GO:0019227)4.73695376
14* protein localization to synapse (GO:0035418)4.72994831
15regulation of synaptic vesicle exocytosis (GO:2000300)4.61685570
16regulation of long-term neuronal synaptic plasticity (GO:0048169)4.58240565
17neurotransmitter-gated ion channel clustering (GO:0072578)4.56366308
18* glutamate receptor signaling pathway (GO:0007215)4.53370198
19synaptic vesicle maturation (GO:0016188)4.52376066
20synaptic transmission, glutamatergic (GO:0035249)4.48013534
21neuron-neuron synaptic transmission (GO:0007270)4.45333118
22presynaptic membrane assembly (GO:0097105)4.42752508
23regulation of neuronal synaptic plasticity (GO:0048168)4.31579082
24positive regulation of calcium ion-dependent exocytosis (GO:0045956)4.29957613
25regulation of excitatory postsynaptic membrane potential (GO:0060079)4.26377877
26regulation of synaptic vesicle transport (GO:1902803)4.14405426
27exploration behavior (GO:0035640)4.08982363
28presynaptic membrane organization (GO:0097090)4.08271368
29gamma-aminobutyric acid signaling pathway (GO:0007214)4.07449033
30regulation of postsynaptic membrane potential (GO:0060078)4.05370876
31regulation of dendritic spine morphogenesis (GO:0061001)3.98010365
32long-term synaptic potentiation (GO:0060291)3.97202991
33membrane depolarization during cardiac muscle cell action potential (GO:0086012)3.96788346
34negative regulation of synaptic transmission, GABAergic (GO:0032229)3.93570310
35response to histamine (GO:0034776)3.89004892
36regulation of synaptic plasticity (GO:0048167)3.88512433
37neuron recognition (GO:0008038)3.88049474
38dendritic spine morphogenesis (GO:0060997)3.84320232
39positive regulation of neurotransmitter secretion (GO:0001956)3.83485716
40regulation of synapse structural plasticity (GO:0051823)3.83101697
41long-term memory (GO:0007616)3.78797254
42postsynaptic membrane organization (GO:0001941)3.71000490
43positive regulation of membrane potential (GO:0045838)3.67571779
44positive regulation of synapse maturation (GO:0090129)3.65256473
45regulation of synaptic transmission, glutamatergic (GO:0051966)3.64413866
46axonal fasciculation (GO:0007413)3.63291743
47regulation of inhibitory postsynaptic membrane potential (GO:0060080)3.61829139
48neurotransmitter secretion (GO:0007269)3.61403176
49regulation of dendritic spine development (GO:0060998)3.57399689
50G-protein coupled acetylcholine receptor signaling pathway (GO:0007213)3.56076704
51regulation of glutamate secretion (GO:0014048)3.54262074
52behavioral fear response (GO:0001662)3.51239428
53behavioral defense response (GO:0002209)3.51239428
54layer formation in cerebral cortex (GO:0021819)3.50216386
55negative regulation of synaptic transmission, glutamatergic (GO:0051967)3.45592604
56positive regulation of synaptic transmission, glutamatergic (GO:0051968)3.42862184
57positive regulation of neurotransmitter transport (GO:0051590)3.40951972
58regulation of voltage-gated calcium channel activity (GO:1901385)3.40656399
59regulation of neurotransmitter secretion (GO:0046928)3.40343429
60proline transport (GO:0015824)3.35229322
61fear response (GO:0042596)3.34638738
62membrane depolarization (GO:0051899)3.32196803
63synaptic vesicle endocytosis (GO:0048488)3.30903162
64negative regulation of amino acid transport (GO:0051956)3.28858879
65gamma-aminobutyric acid transport (GO:0015812)3.24391371
66cerebellar granule cell differentiation (GO:0021707)3.22304643
67regulation of gene silencing by RNA (GO:0060966)3.21319109
68regulation of posttranscriptional gene silencing (GO:0060147)3.21319109
69regulation of gene silencing by miRNA (GO:0060964)3.21319109
70transmission of nerve impulse (GO:0019226)3.19281004
71learning (GO:0007612)3.18103539
72auditory behavior (GO:0031223)3.17933428
73pre-miRNA processing (GO:0031054)3.16162760
74chromatin remodeling at centromere (GO:0031055)3.14584885
75paraxial mesoderm development (GO:0048339)3.13882005
76dendritic spine organization (GO:0097061)3.13363946
77long term synaptic depression (GO:0060292)3.13212595
78regulation of neurotransmitter transport (GO:0051588)3.10054768
79regulation of vesicle fusion (GO:0031338)3.09756032
80detection of calcium ion (GO:0005513)3.07964315
81establishment of integrated proviral latency (GO:0075713)3.07584212
82* G-protein coupled glutamate receptor signaling pathway (GO:0007216)3.07018195
83positive regulation of synaptic transmission (GO:0050806)3.06341356
84activation of protein kinase A activity (GO:0034199)3.05487687
85cellular potassium ion homeostasis (GO:0030007)3.03740850
86membrane depolarization during action potential (GO:0086010)3.03664117
87positive regulation of ryanodine-sensitive calcium-release channel activity (GO:0060316)3.01688953
88CENP-A containing nucleosome assembly (GO:0034080)3.01049321
89neuromuscular process controlling balance (GO:0050885)2.99833707
90mechanosensory behavior (GO:0007638)2.99138828
91regulation of synaptic transmission (GO:0050804)2.98317129
92nuclear pore complex assembly (GO:0051292)2.98021274
93negative regulation of dendrite development (GO:2000171)2.96804270
94positive regulation of potassium ion transmembrane transporter activity (GO:1901018)2.96676899
95cerebellar Purkinje cell differentiation (GO:0021702)2.95740273
96regulation of synapse maturation (GO:0090128)2.94552767
97neurotransmitter transport (GO:0006836)2.94165937
98positive regulation of dendritic spine development (GO:0060999)2.93948085
99startle response (GO:0001964)2.92157159
100membrane hyperpolarization (GO:0060081)2.91595503
101regulation of respiratory gaseous exchange by neurological system process (GO:0002087)2.91269341
102response to auditory stimulus (GO:0010996)2.90876528
103* synaptic transmission (GO:0007268)2.90867730
104positive regulation of dendritic spine morphogenesis (GO:0061003)2.90236437
105serotonin metabolic process (GO:0042428)2.87754143
106* behavioral response to cocaine (GO:0048148)2.87366032
107negative regulation of dendrite morphogenesis (GO:0050774)2.86591668
108vesicle transport along microtubule (GO:0047496)2.86586447
109cochlea development (GO:0090102)2.84766771
110sarcoplasmic reticulum calcium ion transport (GO:0070296)2.84705053
111mitotic metaphase plate congression (GO:0007080)2.83895315
112histone exchange (GO:0043486)2.83007680
113nuclear pore organization (GO:0006999)2.81443386
114mitotic sister chromatid cohesion (GO:0007064)2.72719966
115protein complex localization (GO:0031503)2.70890709
116regulation of attachment of spindle microtubules to kinetochore (GO:0051988)2.70873293
117regulation of atrial cardiac muscle cell membrane depolarization (GO:0060371)2.69975316
118establishment of protein localization to mitochondrial membrane (GO:0090151)2.66238608
119cellular protein complex localization (GO:0034629)2.54296791
120protein localization to kinetochore (GO:0034501)2.50335199
121anterior/posterior axis specification, embryo (GO:0008595)2.49968649
122regulation of helicase activity (GO:0051095)2.47754764
123mitochondrial ATP synthesis coupled proton transport (GO:0042776)2.45868073
124atrial cardiac muscle cell action potential (GO:0086014)2.45087638
125metaphase plate congression (GO:0051310)2.44123752
126IMP metabolic process (GO:0046040)2.41677811
127DNA replication-independent nucleosome assembly (GO:0006336)2.41251737
128DNA replication-independent nucleosome organization (GO:0034724)2.41251737
129mitotic chromosome condensation (GO:0007076)2.39944101
130regulation of mitotic cell cycle spindle assembly checkpoint (GO:0090266)2.39218095
131regulation of mitotic spindle checkpoint (GO:1903504)2.39218095
132cell communication by electrical coupling (GO:0010644)2.38826924
133notochord development (GO:0030903)2.38788821
134DNA replication checkpoint (GO:0000076)2.34695025
135IMP biosynthetic process (GO:0006188)2.34347124
136regulation of centriole replication (GO:0046599)2.34285511
137cell communication involved in cardiac conduction (GO:0086065)2.33642909
138negative regulation of metaphase/anaphase transition of cell cycle (GO:1902100)2.33614190
139negative regulation of mitotic sister chromatid segregation (GO:0033048)2.33614190
140negative regulation of mitotic sister chromatid separation (GO:2000816)2.33614190
141negative regulation of sister chromatid segregation (GO:0033046)2.33614190
142negative regulation of mitotic metaphase/anaphase transition (GO:0045841)2.33614190
143chaperone-mediated protein transport (GO:0072321)2.30853124
144heterochromatin organization (GO:0070828)2.29680948
145negative regulation of translation, ncRNA-mediated (GO:0040033)2.29203407
146regulation of translation, ncRNA-mediated (GO:0045974)2.29203407
147negative regulation of translation involved in gene silencing by miRNA (GO:0035278)2.29203407
148actin-myosin filament sliding (GO:0033275)2.28701959
149muscle filament sliding (GO:0030049)2.28701959
150negative regulation of chromosome segregation (GO:0051985)2.27830259
151cell communication by electrical coupling involved in cardiac conduction (GO:0086064)2.27251853
152regulation of sister chromatid segregation (GO:0033045)2.26602226
153regulation of mitotic sister chromatid separation (GO:0010965)2.26602226
154regulation of mitotic sister chromatid segregation (GO:0033047)2.26602226
155otic vesicle formation (GO:0030916)2.25809944
156regulation of cell communication by electrical coupling (GO:0010649)2.24887583
157generation of neurons (GO:0048699)2.24776007
158spindle checkpoint (GO:0031577)2.24183215
159kinetochore organization (GO:0051383)2.21799439
160negative regulation of DNA-dependent DNA replication (GO:2000104)2.21427979
161regulation of cell fate specification (GO:0042659)2.18659923
162regulation of metaphase/anaphase transition of cell cycle (GO:1902099)2.18393419
163regulation of mitotic metaphase/anaphase transition (GO:0030071)2.18393419
164regulation of DNA endoreduplication (GO:0032875)2.18204101
165regulation of chromosome segregation (GO:0051983)2.17558660
166protein localization to chromosome, centromeric region (GO:0071459)2.14589823
167cardiac muscle cell action potential (GO:0086001)2.14160839
168mitotic spindle checkpoint (GO:0071174)2.13463574
169regulation of release of sequestered calcium ion into cytosol by sarcoplasmic reticulum (GO:0010880)2.12155292
170cardiac muscle cell action potential involved in contraction (GO:0086002)2.07464222
171DNA damage response, detection of DNA damage (GO:0042769)2.05555867
172pore complex assembly (GO:0046931)2.05255084
173DNA unwinding involved in DNA replication (GO:0006268)2.04203295
174mitotic spindle assembly checkpoint (GO:0007094)2.03832950
175negative regulation of mitosis (GO:0045839)2.03495516
176regulation of histone H3-K9 methylation (GO:0051570)2.02482034
177telomere maintenance via telomerase (GO:0007004)2.01691150
178sodium ion export (GO:0071436)2.01394051
179cardiac muscle hypertrophy (GO:0003300)2.00591631
180regulation of actin filament-based movement (GO:1903115)2.00090945
181spindle assembly checkpoint (GO:0071173)1.99940959
182regulation of meiosis I (GO:0060631)1.98991000

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1EZH2_22144423_ChIP-Seq_EOC_Human6.02222168
2GBX2_23144817_ChIP-Seq_PC3_Human4.19346742
3E2F7_22180533_ChIP-Seq_HELA_Human4.02224248
4SUZ12_18692474_ChIP-Seq_MESCs_Mouse3.04226624
5JARID2_20064375_ChIP-Seq_MESCs_Mouse2.97507936
6SUZ12_18555785_ChIP-Seq_MESCs_Mouse2.94950283
7SALL1_21062744_ChIP-ChIP_HESCs_Human2.62478689
8SUZ12_18974828_ChIP-Seq_MESCs_Mouse2.59782269
9RBPJ_22232070_ChIP-Seq_NCS_Mouse2.57421691
10RNF2_18974828_ChIP-Seq_MESCs_Mouse2.51834643
11EZH2_18974828_ChIP-Seq_MESCs_Mouse2.51834643
12RARB_27405468_Chip-Seq_BRAIN_Mouse2.48051135
13SUZ12_18692474_ChIP-Seq_MEFs_Mouse2.40544958
14JARID2_20075857_ChIP-Seq_MESCs_Mouse2.37295401
15REST_21632747_ChIP-Seq_MESCs_Mouse2.37229743
16SUZ12_16625203_ChIP-ChIP_MESCs_Mouse2.35731631
17EZH2_27304074_Chip-Seq_ESCs_Mouse2.33890397
18MTF2_20144788_ChIP-Seq_MESCs_Mouse2.29560401
19E2F4_17652178_ChIP-ChIP_JURKAT_Human2.22872450
20SUZ12_20075857_ChIP-Seq_MESCs_Mouse2.22030349
21EED_16625203_ChIP-ChIP_MESCs_Mouse2.21462055
22FOXM1_23109430_ChIP-Seq_U2OS_Human2.19012588
23DROSHA_22980978_ChIP-Seq_HELA_Human2.17178148
24TAF15_26573619_Chip-Seq_HEK293_Human2.16568727
25E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse2.15031238
26KDM5B_21448134_ChIP-Seq_MESCs_Mouse2.07719271
27AR_21572438_ChIP-Seq_LNCaP_Human2.07186247
28CTBP2_25329375_ChIP-Seq_LNCAP_Human2.04426640
29RNF2_27304074_Chip-Seq_ESCs_Mouse2.01224506
30SMAD_19615063_ChIP-ChIP_OVARY_Human1.99938159
31MYCN_21190229_ChIP-Seq_SHEP-21N_Human1.99738699
32CTBP1_25329375_ChIP-Seq_LNCAP_Human1.99035478
33SMARCD1_25818293_ChIP-Seq_ESCs_Mouse1.95660402
34SUZ12_27294783_Chip-Seq_ESCs_Mouse1.95630480
35EZH2_27294783_Chip-Seq_ESCs_Mouse1.94811022
36ZFP57_27257070_Chip-Seq_ESCs_Mouse1.94280124
37AR_21909140_ChIP-Seq_LNCAP_Human1.87896070
38ZFP322A_24550733_ChIP-Seq_MESCs_Mouse1.87011942
39SMAD4_21799915_ChIP-Seq_A2780_Human1.84487273
40POU5F1_16153702_ChIP-ChIP_HESCs_Human1.84222927
41MYC_18555785_ChIP-Seq_MESCs_Mouse1.83197613
42REST_18959480_ChIP-ChIP_MESCs_Mouse1.78496371
43HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse1.76077407
44P300_19829295_ChIP-Seq_ESCs_Human1.75358586
45EWS_26573619_Chip-Seq_HEK293_Human1.69526753
46GLI1_17442700_ChIP-ChIP_MESCs_Mouse1.68576850
47FUS_26573619_Chip-Seq_HEK293_Human1.66294684
48PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human1.61785374
49SMAD3_21741376_ChIP-Seq_EPCs_Human1.61595104
50* POU3F2_20337985_ChIP-ChIP_501MEL_Human1.60690488
51KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human1.59605069
52TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.57529867
53GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.57448915
54IKZF1_21737484_ChIP-ChIP_HCT116_Human1.55079036
55SMAD2/3_21741376_ChIP-Seq_EPCs_Human1.53352795
56PIAS1_25552417_ChIP-Seq_VCAP_Human1.46412796
57NR4A2_19515692_ChIP-ChIP_MN9D_Mouse1.45251988
58SOX2_16153702_ChIP-ChIP_HESCs_Human1.44337682
59GATA1_26923725_Chip-Seq_HPCs_Mouse1.43876846
60CEBPD_23245923_ChIP-Seq_MEFs_Mouse1.43867649
61AR_25329375_ChIP-Seq_VCAP_Human1.41360813
62NANOG_16153702_ChIP-ChIP_HESCs_Human1.41004423
63TOP2B_26459242_ChIP-Seq_MCF-7_Human1.40266915
64KLF2_18264089_ChIP-ChIP_MESCs_Mouse1.39770805
65KLF5_18264089_ChIP-ChIP_MESCs_Mouse1.39770805
66KLF4_18264089_ChIP-ChIP_MESCs_Mouse1.39770805
67CDKN2AIP_20523734_ChIP-Seq_CORTICAL_Neurons1.38639807
68SOX2_21211035_ChIP-Seq_LN229_Gbm1.38565482
69OLIG2_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.37857655
70TP53_16413492_ChIP-PET_HCT116_Human1.37261352
71MYCN_19997598_ChIP-ChIP_NEUROBLASTOMA_Human1.36410482
72RCOR2_21632747_ChIP-Seq_MESCs_Mouse1.35901960
73STAT3_23295773_ChIP-Seq_U87_Human1.35136231
74SMARCA4_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.34238241
75MYC_19079543_ChIP-ChIP_MESCs_Mouse1.33584866
76SALL4_18804426_ChIP-ChIP_MESCs_Mouse1.33017555
77RNF2_16625203_ChIP-ChIP_MESCs_Mouse1.32567293
78* TCF3_18467660_ChIP-ChIP_MESCs_Mouse1.32146260
79NR3C1_23031785_ChIP-Seq_PC12_Mouse1.31851455
80CBX2_27304074_Chip-Seq_ESCs_Mouse1.31717756
81PHC1_16625203_ChIP-ChIP_MESCs_Mouse1.30729635
82* ZNF217_24962896_ChIP-Seq_MCF-7_Human1.30508467
83NANOG_18700969_ChIP-ChIP_MESCs_Mouse1.29607075
84TCF3/E2A_22897851_ChIP-Seq_JUKARTE6-1_Human1.28162694
85ZNF274_21170338_ChIP-Seq_K562_Hela1.27991635
86E2F1_21310950_ChIP-Seq_MCF-7_Human1.26946684
87FOXM1_25889361_ChIP-Seq_OE33_AND_U2OS_Human1.26890092
88ARNT_22903824_ChIP-Seq_MCF-7_Human1.25876126
89* TCF4_23295773_ChIP-Seq_U87_Human1.25858587
90BMI1_23680149_ChIP-Seq_NPCS_Mouse1.25658083
91AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human1.23804877
92YY1_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse1.23200558
93MEIS1_26253404_ChIP-Seq_OPTIC_CUPS_Mouse1.22590237
94CDX2_19796622_ChIP-Seq_MESCs_Mouse1.20893110
95* CHD1_19587682_ChIP-ChIP_MESCs_Mouse1.20639162
96TP53_18474530_ChIP-ChIP_U2OS_Human1.18759097
97EZH2_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse1.18314152
98FLI1_27457419_Chip-Seq_LIVER_Mouse1.18286313
99AHR_22903824_ChIP-Seq_MCF-7_Human1.17585657
100UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human1.17518842
101NACC1_18358816_ChIP-ChIP_MESCs_Mouse1.17460311
102* AR_19668381_ChIP-Seq_PC3_Human1.17007967
103P53_22127205_ChIP-Seq_FIBROBLAST_Human1.16739450
104PRDM14_20953172_ChIP-Seq_ESCs_Human1.15318708
105POU5F1_26923725_Chip-Seq_MESODERM_Mouse1.15295636
106TEAD4_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.15295636
107VDR_23401126_ChIP-Seq_LCL-AND-THP1_Human1.15243837
108VDR_22108803_ChIP-Seq_LS180_Human1.15014634
109HOXD13_18407260_ChIP-ChIP_DEVELOPING-LIMBS_Mouse1.14441943
110TAL1_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.13890269
111TCFCP2L1_18555785_Chip-Seq_ESCs_Mouse1.13517264
112ER_23166858_ChIP-Seq_MCF-7_Human1.13513016
113ERG_21242973_ChIP-ChIP_JURKAT_Human1.12091780
114MYC_19030024_ChIP-ChIP_MESCs_Mouse1.12034718
115NANOG_18555785_Chip-Seq_ESCs_Mouse1.11249554
116BCL11B_21912641_ChIP-Seq_STHDH_STRIUM_Mouse1.10125959
117RNF2_27304074_Chip-Seq_NSC_Mouse1.08946871
118EP300_21415370_ChIP-Seq_HL-1_Mouse1.08708875
119RING1B_27294783_Chip-Seq_ESCs_Mouse1.08559436
120* RCOR1_19997604_ChIP-ChIP_NEURONS_Mouse1.08479913
121TBX3_20139965_ChIP-Seq_MESCs_Mouse1.08457647
122TBX3_20139965_ChIP-Seq_ESCs_Mouse1.08324161
123NR3C1_21868756_ChIP-Seq_MCF10A_Human1.08150452
124EST1_17652178_ChIP-ChIP_JURKAT_Human1.07984181
125POU5F1_18347094_ChIP-ChIP_MESCs_Mouse1.07667329
126RUNX2_22187159_ChIP-Seq_PCA_Human1.07191476
127YAP1_20516196_ChIP-Seq_MESCs_Mouse1.07109299
128CREB1_15753290_ChIP-ChIP_HEK293T_Human1.05960802
129MYC_18940864_ChIP-ChIP_HL60_Human1.05769098
130* ELK1_19687146_ChIP-ChIP_HELA_Human1.05446965
131CEBPB_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.05294171
132* WT1_25993318_ChIP-Seq_PODOCYTE_Human1.03938005
133RING1B_27294783_Chip-Seq_NPCs_Mouse1.02310014
134E2F1_18555785_Chip-Seq_ESCs_Mouse1.02160381
135STAT3_24763339_ChIP-Seq_IMN-ESCs_Mouse1.01792619
136JUN_21703547_ChIP-Seq_K562_Human1.01172508
137SMAD3_21741376_ChIP-Seq_HESCs_Human1.00584202
138IGF1R_20145208_ChIP-Seq_DFB_Human1.00300309
139PRDM16_22522345_ChIP-ChIP_PALATE_MESENCHYMAL_Mouse1.00295950
140FOXP2_21765815_ChIP-ChIP_NEURO2A_Mouse1.00078684
141RXR_22108803_ChIP-Seq_LS180_Human0.99502619
142* CEBPB_26923725_Chip-Seq_MESODERM_Mouse0.99383768
143BCAT_22108803_ChIP-Seq_LS180_Human0.98282327
144TCF3_18692474_ChIP-Seq_MESCs_Mouse0.98242788
145POU5F1_18358816_ChIP-ChIP_MESCs_Mouse0.97082513
146MEIS1_26923725_Chip-Seq_HEMOGENIC-ENDOTHELIUM_Mouse0.97004480
147KLF4_25985364_ChIP-Seq_ATHEROSCLEROSIS_LESION_Mouse0.96368451
148TEAD4_22529382_ChIP-Seq_TROPHECTODERM_Mouse0.95541220
149MYCN_18555785_ChIP-Seq_MESCs_Mouse0.95524728
150SOX2_19030024_ChIP-ChIP_MESCs_Mouse0.95377856
151PCGF2_27294783_Chip-Seq_ESCs_Mouse0.95259000
152TRIM28_17542650_ChIP-ChIP_NTERA2_Human0.94437225
153GABP_17652178_ChIP-ChIP_JURKAT_Human0.94130546
154P53_22387025_ChIP-Seq_ESCs_Mouse0.93546899
155RCOR3_21632747_ChIP-Seq_MESCs_Mouse0.93442417
156SOX9_26525672_Chip-Seq_HEART_Mouse0.93242229

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0004859_abnormal_synaptic_plasticity6.77809692
2MP0003880_abnormal_central_pattern5.56995892
3MP0003635_abnormal_synaptic_transmissio4.22358393
4MP0004270_analgesia4.00203771
5* MP0009745_abnormal_behavioral_response3.71038098
6* MP0002063_abnormal_learning/memory/cond3.56443908
7MP0002064_seizures3.24506433
8MP0001968_abnormal_touch/_nociception3.03164940
9MP0002822_catalepsy2.98293167
10MP0002572_abnormal_emotion/affect_behav2.95221775
11MP0009046_muscle_twitch2.92597605
12MP0003941_abnormal_skin_development2.75935078
13MP0001486_abnormal_startle_reflex2.63598433
14MP0002272_abnormal_nervous_system2.58075662
15MP0001501_abnormal_sleep_pattern2.47826865
16MP0003890_abnormal_embryonic-extraembry2.47124280
17MP0002736_abnormal_nociception_after2.44896054
18MP0002734_abnormal_mechanical_nocicepti2.44353630
19MP0001440_abnormal_grooming_behavior2.30559332
20MP0008057_abnormal_DNA_replication2.24068950
21MP0008877_abnormal_DNA_methylation2.12929832
22MP0002735_abnormal_chemical_nociception2.12485501
23MP0009780_abnormal_chondrocyte_physiolo2.08662801
24MP0005423_abnormal_somatic_nervous2.01446664
25MP0002067_abnormal_sensory_capabilities1.97608426
26MP0006292_abnormal_olfactory_placode1.97336711
27MP0004924_abnormal_behavior1.85119794
28MP0005386_behavior/neurological_phenoty1.85119794
29MP0000778_abnormal_nervous_system1.84385649
30MP0004957_abnormal_blastocyst_morpholog1.78095144
31MP0003123_paternal_imprinting1.72751662
32MP0001970_abnormal_pain_threshold1.72613432
33MP0003879_abnormal_hair_cell1.72029496
34MP0002733_abnormal_thermal_nociception1.71125988
35MP0003787_abnormal_imprinting1.70799891
36MP0001529_abnormal_vocalization1.69075788
37MP0003329_amyloid_beta_deposits1.68479348
38MP0003693_abnormal_embryo_hatching1.65927765
39MP0002557_abnormal_social/conspecific_i1.65405278
40MP0008569_lethality_at_weaning1.63046923
41MP0001293_anophthalmia1.62043330
42MP0003937_abnormal_limbs/digits/tail_de1.60469265
43MP0002837_dystrophic_cardiac_calcinosis1.58348432
44MP0001188_hyperpigmentation1.58207525
45MP0000579_abnormal_nail_morphology1.57990052
46MP0005646_abnormal_pituitary_gland1.56933917
47MP0004811_abnormal_neuron_physiology1.56536108
48MP0004145_abnormal_muscle_electrophysio1.56215905
49MP0002184_abnormal_innervation1.54927168
50MP0010094_abnormal_chromosome_stability1.45863581
51MP0001299_abnormal_eye_distance/1.41969320
52MP0008058_abnormal_DNA_repair1.40493306
53MP0009672_abnormal_birth_weight1.39658921
54MP0000751_myopathy1.38036806
55MP0009379_abnormal_foot_pigmentation1.36239521
56MP0002066_abnormal_motor_capabilities/c1.33768912
57MP0001984_abnormal_olfaction1.33367634
58MP0010030_abnormal_orbit_morphology1.33298388
59MP0003111_abnormal_nucleus_morphology1.32486596
60MP0002697_abnormal_eye_size1.28620579
61MP0008932_abnormal_embryonic_tissue1.27912966
62MP0000955_abnormal_spinal_cord1.26874002
63MP0002909_abnormal_adrenal_gland1.26457978
64MP0003119_abnormal_digestive_system1.25204796
65MP0002882_abnormal_neuron_morphology1.24882382
66MP0001905_abnormal_dopamine_level1.24806396
67MP0004510_myositis1.24800537
68MP0004858_abnormal_nervous_system1.24073510
69MP0003121_genomic_imprinting1.23283912
70* MP0003633_abnormal_nervous_system1.22300256
71MP0003136_yellow_coat_color1.21914139
72MP0004084_abnormal_cardiac_muscle1.21661016
73MP0003077_abnormal_cell_cycle1.18068762
74MP0006276_abnormal_autonomic_nervous1.17068307
75MP0001502_abnormal_circadian_rhythm1.16723279
76MP0004484_altered_response_of1.15041103
77MP0009697_abnormal_copulation1.14797596
78MP0004885_abnormal_endolymph1.11457784
79MP0002233_abnormal_nose_morphology1.11252005
80MP0003861_abnormal_nervous_system1.08644236
81MP0002084_abnormal_developmental_patter1.08073796
82MP0003567_abnormal_fetal_cardiomyocyte1.07572157
83MP0003718_maternal_effect1.06748902
84* MP0003631_nervous_system_phenotype1.05938386
85MP0004215_abnormal_myocardial_fiber1.05467971
86MP0004085_abnormal_heartbeat1.03349955
87MP0005171_absent_coat_pigmentation1.02569405
88MP0002152_abnormal_brain_morphology1.00156044
89MP0004142_abnormal_muscle_tone0.99515921
90MP0010352_gastrointestinal_tract_polyps0.99197999
91MP0001286_abnormal_eye_development0.97898951
92MP0000049_abnormal_middle_ear0.97884340
93MP0008874_decreased_physiological_sensi0.97800416
94MP0002085_abnormal_embryonic_tissue0.97279699
95MP0002234_abnormal_pharynx_morphology0.97240112
96MP0004742_abnormal_vestibular_system0.95697369
97MP0000762_abnormal_tongue_morphology0.95664225
98MP0008872_abnormal_physiological_respon0.94299545
99MP0009703_decreased_birth_body0.93704431
100MP0005409_darkened_coat_color0.90358672
101MP0000428_abnormal_craniofacial_morphol0.90304580
102MP0000569_abnormal_digit_pigmentation0.89559285
103MP0001730_embryonic_growth_arrest0.88415585
104MP0003075_altered_response_to0.88292457
105MP0002069_abnormal_eating/drinking_beha0.86848857
106MP0003755_abnormal_palate_morphology0.86065260
107MP0004087_abnormal_muscle_fiber0.85706183
108MP0000747_muscle_weakness0.85334369
109MP0005535_abnormal_body_temperature0.84815606
110MP0001485_abnormal_pinna_reflex0.84636189
111MP0001672_abnormal_embryogenesis/_devel0.84199280
112MP0005380_embryogenesis_phenotype0.84199280
113MP0001697_abnormal_embryo_size0.84181412
114MP0001963_abnormal_hearing_physiology0.83836521
115MP0001177_atelectasis0.83105803
116MP0002106_abnormal_muscle_physiology0.82767627
117MP0002160_abnormal_reproductive_system0.82590083
118MP0000566_synostosis0.81980070
119MP0003385_abnormal_body_wall0.81223346
120MP0000604_amyloidosis0.80943803
121MP0003646_muscle_fatigue0.80211655
122MP0002269_muscular_atrophy0.80153016
123MP0001346_abnormal_lacrimal_gland0.79972765
124MP0005620_abnormal_muscle_contractility0.78339604
125MP0003938_abnormal_ear_development0.77596018
126MP0008961_abnormal_basal_metabolism0.77297840
127MP0002876_abnormal_thyroid_physiology0.74910958
128MP0002229_neurodegeneration0.74129129
129MP0005551_abnormal_eye_electrophysiolog0.72727649
130MP0003632_abnormal_nervous_system0.72605314
131MP0003137_abnormal_impulse_conducting0.72365394
132MP0005645_abnormal_hypothalamus_physiol0.69506309
133MP0000920_abnormal_myelination0.69441632
134MP0004036_abnormal_muscle_relaxation0.69240658
135MP0004233_abnormal_muscle_weight0.67725962
136MP0003122_maternal_imprinting0.67562990
137MP0010386_abnormal_urinary_bladder0.66854160
138MP0000749_muscle_degeneration0.66408552
139MP0000631_abnormal_neuroendocrine_gland0.63004122
140MP0003690_abnormal_glial_cell0.62744469
141MP0001664_abnormal_digestion0.61756488
142MP0005187_abnormal_penis_morphology0.61239503
143MP0000013_abnormal_adipose_tissue0.59134354
144MP0002752_abnormal_somatic_nervous0.58987710
145MP0002090_abnormal_vision0.58130989
146MP0010234_abnormal_vibrissa_follicle0.57453117
147MP0003634_abnormal_glial_cell0.56269375
148MP0001943_abnormal_respiration0.53406742
149MP0002972_abnormal_cardiac_muscle0.53352161
150MP0005394_taste/olfaction_phenotype0.49990627
151MP0005499_abnormal_olfactory_system0.49990627
152MP0004130_abnormal_muscle_cell0.49044797
153MP0000026_abnormal_inner_ear0.48858250

Predicted human phenotypes

RankGene SetZ-score
1Focal motor seizures (HP:0011153)9.36047193
2Focal seizures (HP:0007359)6.10776655
3Myokymia (HP:0002411)5.91837559
4Epileptic encephalopathy (HP:0200134)5.79732242
5Atonic seizures (HP:0010819)5.38898402
6Hyperventilation (HP:0002883)5.30054985
7Febrile seizures (HP:0002373)4.82757563
8Visual hallucinations (HP:0002367)4.72880228
9Broad-based gait (HP:0002136)4.68834903
10Absence seizures (HP:0002121)4.64346949
11Dialeptic seizures (HP:0011146)4.39076994
12Generalized tonic-clonic seizures (HP:0002069)4.07196556
13Poor eye contact (HP:0000817)3.84670214
14Gaze-evoked nystagmus (HP:0000640)3.80598121
15Progressive cerebellar ataxia (HP:0002073)3.77160194
16Amblyopia (HP:0000646)3.41723671
17Drooling (HP:0002307)3.33137298
18Excessive salivation (HP:0003781)3.33137298
19Colon cancer (HP:0003003)3.30359405
20Impaired vibration sensation in the lower limbs (HP:0002166)3.27917240
21Abnormal social behavior (HP:0012433)3.26836239
22Impaired social interactions (HP:0000735)3.26836239
23Protruding tongue (HP:0010808)3.13220140
24Absent speech (HP:0001344)3.11618671
25Nemaline bodies (HP:0003798)3.10404081
26Urinary bladder sphincter dysfunction (HP:0002839)3.06734236
27Muscle fiber inclusion bodies (HP:0100299)3.05395931
28Dysdiadochokinesis (HP:0002075)3.02108926
29Truncal ataxia (HP:0002078)3.01034384
30Action tremor (HP:0002345)2.98726982
31Dysmetria (HP:0001310)2.95633089
32Muscle fiber cytoplasmatic inclusion bodies (HP:0100303)2.95556369
33Exercise-induced muscle cramps (HP:0003710)2.89689316
34Dysmetric saccades (HP:0000641)2.82693016
35Epileptiform EEG discharges (HP:0011182)2.80421360
36Impaired smooth pursuit (HP:0007772)2.78783335
37Abnormality of the labia minora (HP:0012880)2.78046365
38Termporal pattern (HP:0011008)2.74810956
39Insidious onset (HP:0003587)2.74810956
40Septo-optic dysplasia (HP:0100842)2.73940273
41Inability to walk (HP:0002540)2.68507472
42Blue irides (HP:0000635)2.68318089
43Cerebral inclusion bodies (HP:0100314)2.66178430
44Anxiety (HP:0000739)2.63251390
45Depression (HP:0000716)2.63049953
46Stereotypic behavior (HP:0000733)2.62474458
47Fair hair (HP:0002286)2.62215155
48Lower limb amyotrophy (HP:0007210)2.59184682
49Scanning speech (HP:0002168)2.51509549
50Urinary urgency (HP:0000012)2.50297219
51Generalized hypopigmentation of hair (HP:0011358)2.45045525
52Ankle clonus (HP:0011448)2.42976642
53EEG with generalized epileptiform discharges (HP:0011198)2.42788868
54Hepatoblastoma (HP:0002884)2.42024605
55Genetic anticipation (HP:0003743)2.41559637
56Supranuclear gaze palsy (HP:0000605)2.41277234
57Fetal akinesia sequence (HP:0001989)2.39817837
58Abnormality of the lower motor neuron (HP:0002366)2.38077875
59Abnormal eating behavior (HP:0100738)2.37368309
60Inappropriate behavior (HP:0000719)2.36608646
61Impaired vibratory sensation (HP:0002495)2.35573266
62Postural instability (HP:0002172)2.34746799
63Rimmed vacuoles (HP:0003805)2.32803743
64Hemiparesis (HP:0001269)2.27207101
65Generalized myoclonic seizures (HP:0002123)2.27115744
66Bundle branch block (HP:0011710)2.27110334
67Limb dystonia (HP:0002451)2.26752205
68Abnormality of salivation (HP:0100755)2.25334480
69Abnormality of ocular smooth pursuit (HP:0000617)2.25284966
70Status epilepticus (HP:0002133)2.23606455
71Abnormality of binocular vision (HP:0011514)2.21940728
72Diplopia (HP:0000651)2.21940728
73Progressive inability to walk (HP:0002505)2.21898692
74Muscle hypertrophy of the lower extremities (HP:0008968)2.21575522
75Hypsarrhythmia (HP:0002521)2.20496139
76Incomplete penetrance (HP:0003829)2.17033364
77Exercise-induced myalgia (HP:0003738)2.16726022
78Birth length less than 3rd percentile (HP:0003561)2.16355068
79Sudden death (HP:0001699)2.16250889
80Spastic gait (HP:0002064)2.16062687
81Neurofibrillary tangles (HP:0002185)2.16039653
82Resting tremor (HP:0002322)2.11799354
83Bradykinesia (HP:0002067)2.11490354
84Abnormality of the corticospinal tract (HP:0002492)2.10035252
85Papillary thyroid carcinoma (HP:0002895)2.07886735
86Distal lower limb amyotrophy (HP:0008944)2.07832652
87Mutism (HP:0002300)2.05231711
88Torticollis (HP:0000473)2.04981971
89Syncope (HP:0001279)2.00853308
90Lower limb muscle weakness (HP:0007340)1.98647476
91Abnormality of the septum pellucidum (HP:0007375)1.98183712
92Calf muscle hypertrophy (HP:0008981)1.97501707
93Thickened helices (HP:0000391)1.96156960
94Clumsiness (HP:0002312)1.95902222
95Absent septum pellucidum (HP:0001331)1.95853235
96Abnormal lung lobation (HP:0002101)1.94653290
97Volvulus (HP:0002580)1.94201071
98Chromsome breakage (HP:0040012)1.92260426
99Shoulder girdle muscle weakness (HP:0003547)1.92149031
100Maternal diabetes (HP:0009800)1.92063093
101Abnormality of the calf musculature (HP:0001430)1.91120676
102Widely spaced teeth (HP:0000687)1.90901101
103Multiple enchondromatosis (HP:0005701)1.88858888
104Degeneration of the lateral corticospinal tracts (HP:0002314)1.88528513
105Atrophy/Degeneration involving the corticospinal tracts (HP:0007372)1.88528513
106Focal dystonia (HP:0004373)1.87919745
107Gait ataxia (HP:0002066)1.87417416
108Exotropia (HP:0000577)1.87408594
109Optic nerve hypoplasia (HP:0000609)1.85611994
110Deeply set eye (HP:0000490)1.84996866
111Stenosis of the external auditory canal (HP:0000402)1.83917884
112Chromosomal breakage induced by crosslinking agents (HP:0003221)1.83577360
113Intention tremor (HP:0002080)1.82499448
114Aqueductal stenosis (HP:0002410)1.82305597
115Lower limb asymmetry (HP:0100559)1.81654560
116Rhabdomyosarcoma (HP:0002859)1.79750675
117Gastroesophageal reflux (HP:0002020)1.79338868
118Bifid tongue (HP:0010297)1.79252665
119Embryonal renal neoplasm (HP:0011794)1.78557653
120Pheochromocytoma (HP:0002666)1.76951987
121Aplasia/Hypoplasia of the optic nerve (HP:0008058)1.76495007
122Partial duplication of thumb phalanx (HP:0009944)1.76328873
123Nephroblastoma (Wilms tumor) (HP:0002667)1.72881734
124Autism (HP:0000717)1.72786583
125Meckel diverticulum (HP:0002245)1.72474676
126Medulloblastoma (HP:0002885)1.70727885
127Glioma (HP:0009733)1.70163045
128Bilateral microphthalmos (HP:0007633)1.70098113
129Prolonged QT interval (HP:0001657)1.69626569
130Intellectual disability, profound (HP:0002187)1.69521876
131Facial cleft (HP:0002006)1.68600107
132Absent/shortened dynein arms (HP:0200106)1.67939715
133Dynein arm defect of respiratory motile cilia (HP:0012255)1.67939715
134Papilledema (HP:0001085)1.67088715
135Abnormality of the astrocytes (HP:0100707)1.66115852
136Astrocytoma (HP:0009592)1.66115852
137Aplasia/Hypoplasia of the sternum (HP:0006714)1.66070070
138Megalencephaly (HP:0001355)1.65913299
139Cutaneous syndactyly (HP:0012725)1.63976356
140Cortical dysplasia (HP:0002539)1.63764792
141Acute necrotizing encephalopathy (HP:0006965)1.63188689
142Hyperinsulinemic hypoglycemia (HP:0000825)1.61773919
143Choanal stenosis (HP:0000452)1.61024710
144Abnormality of chromosome stability (HP:0003220)1.60137388
145Calcaneovalgus deformity (HP:0001848)1.60104322
146Cutaneous finger syndactyly (HP:0010554)1.59787099
147Abnormality of the ileum (HP:0001549)1.59416507
148Anophthalmia (HP:0000528)1.58112319
149Absent eyebrow (HP:0002223)1.58037940
150Decreased number of large peripheral myelinated nerve fibers (HP:0003387)1.55333129
151Reticulocytopenia (HP:0001896)1.54812348
152Duplication of thumb phalanx (HP:0009942)1.54002543
153Subaortic stenosis (HP:0001682)1.53045572
154Abnormality of the left ventricular outflow tract (HP:0011103)1.53045572
155Type 1 muscle fiber predominance (HP:0003803)1.52634957
156Aplasia/Hypoplasia of the uvula (HP:0010293)1.50496623
157Esophageal atresia (HP:0002032)1.48604631
158Heart block (HP:0012722)1.47379579
159Leukodystrophy (HP:0002415)1.46285732
160Partial duplication of the phalanx of hand (HP:0009999)1.46148336
161Acute encephalopathy (HP:0006846)1.45014309
162Midline defect of the nose (HP:0004122)1.44882933
163Dysphonia (HP:0001618)1.44729506
164Sensory axonal neuropathy (HP:0003390)1.44712703
165Vaginal atresia (HP:0000148)1.44615981
166Increased nuchal translucency (HP:0010880)1.44094327
167EMG: myopathic abnormalities (HP:0003458)1.42006582
168Scrotal hypoplasia (HP:0000046)1.41990326
169Distal arthrogryposis (HP:0005684)1.40825429
170Genital tract atresia (HP:0001827)1.39933773
171Preaxial foot polydactyly (HP:0001841)1.36947679
172Neoplasm of the oral cavity (HP:0100649)1.36682678
173Increased hepatocellular lipid droplets (HP:0006565)1.35180291
174Absent radius (HP:0003974)1.34641913
175Progressive macrocephaly (HP:0004481)1.34156418
176Supernumerary spleens (HP:0009799)1.34141284

Predicted kinase interactions (KEA)

RankGene SetZ-score
1EPHA45.66576889
2NTRK34.22291608
3CASK3.40620371
4RIPK43.36863702
5MAP3K43.17359439
6DAPK23.10131216
7MAP3K93.03740608
8CDC72.93821436
9MAP2K72.83046544
10MKNK22.49486854
11MARK12.17121613
12PLK22.16355072
13TTK2.11741381
14MINK12.09242304
15TSSK62.08206498
16DAPK12.02233002
17MAP2K41.98311893
18NEK11.88491242
19TAF11.84150663
20PAK61.80841499
21PBK1.77764279
22MAP3K121.77751085
23CDK191.70718434
24KSR11.68790669
25BUB11.65878335
26MKNK11.62662784
27KSR21.62457773
28BMPR21.61166498
29PLK31.60974339
30TNIK1.58673535
31CAMK1G1.53705562
32SRPK11.53621417
33PRPF4B1.45493522
34PLK41.45432232
35CAMKK11.41165453
36MAP3K131.40935973
37SIK21.40643802
38CDK51.40519276
39NTRK21.37575885
40STK38L1.35379921
41CCNB11.34828107
42NTRK11.30309385
43WEE11.30043372
44PTK2B1.30009117
45WNK31.24081739
46PNCK1.21969468
47GRK51.17188601
48MAPK131.16955078
49ZAK1.15726751
50PRKD31.15152985
51STK241.14874488
52CAMK2A1.14119525
53OXSR11.09235059
54PRKCG1.07563964
55FES1.06966525
56AKT31.06921408
57DYRK21.06274833
58PLK11.05492549
59CAMKK21.04177062
60NME11.03042997
61ARAF1.01826230
62CAMK2B0.96941427
63ALK0.96414123
64FGR0.94018210
65DMPK0.90047409
66FGFR10.89805650
67CSNK1G10.89723400
68LATS10.89687336
69STK390.89375973
70CSNK1E0.88452640
71RAF10.86893067
72CAMK1D0.86849826
73STK160.86322655
74SGK10.85167351
75MAP3K20.83680579
76SGK20.83492699
77MAP3K60.80727837
78SGK2230.79595081
79SGK4940.79595081
80CAMK10.77980260
81CHEK20.75577120
82STK110.75213488
83VRK20.74601656
84MAP3K100.74231580
85BRSK20.73967718
86STK380.73929839
87VRK10.73434753
88CDK180.73351318
89STK30.72973101
90EIF2AK30.71433976
91CDK150.69268045
92TYRO30.69009721
93MST40.66510527
94CDK140.65985871
95DYRK1A0.64689768
96RET0.64400723
97DYRK30.63790102
98TRIM280.63581531
99UHMK10.62192217
100NUAK10.61138870
101PRKCE0.60467131
102PDK10.59704927
103PHKG10.59666023
104PHKG20.59666023
105PDPK10.59607101
106CDK11A0.59103783
107MAP3K70.58101653
108MET0.56854197
109SGK30.56649920
110ATM0.56477536
111TAOK10.56472152
112ERBB40.55367180
113DAPK30.54836600
114MARK20.54527357
115NEK60.54404807
116BMPR1B0.54243972
117CHEK10.53929004
118CAMK2D0.53195793
119MUSK0.52672435
120CSNK1G30.52405089
121SIK30.50969402
122LATS20.50463779
123CDK10.49494436
124BRD40.49187510
125CSNK1G20.48699322
126BRSK10.48639219
127NEK20.48626554
128CSNK1A1L0.48522977
129MAPK120.48045986
130AURKB0.47857804
131PRKDC0.47515503
132ATR0.46056128
133PAK30.45909208
134MAPK70.45475460
135BCR0.44618608
136PINK10.43986109
137RPS6KA30.41262922
138PRKCH0.41045014
139FER0.40275362
140CAMK40.38898793
141CDK30.38767393
142FYN0.37552485
143CAMK2G0.36943499
144PIK3CA0.35198024
145MAP3K50.34884787
146MAP3K10.33590686
147BRAF0.33255151
148OBSCN0.33113005
149MAPK100.31880597
150PRKCZ0.30674965
151MAP2K10.30573711
152ROCK20.29292528
153PRKG10.27878134

Predicted pathways (KEGG)

RankGene SetZ-score
1Nicotine addiction_Homo sapiens_hsa050333.90275317
2Long-term potentiation_Homo sapiens_hsa047202.99593303
3Circadian entrainment_Homo sapiens_hsa047132.84590531
4Synaptic vesicle cycle_Homo sapiens_hsa047212.83594033
5Retrograde endocannabinoid signaling_Homo sapiens_hsa047232.81111772
6Amphetamine addiction_Homo sapiens_hsa050312.75303636
7Olfactory transduction_Homo sapiens_hsa047402.71631586
8Morphine addiction_Homo sapiens_hsa050322.64569059
9* Glutamatergic synapse_Homo sapiens_hsa047242.55987216
10GABAergic synapse_Homo sapiens_hsa047272.45824366
11Salivary secretion_Homo sapiens_hsa049702.24447785
12Dopaminergic synapse_Homo sapiens_hsa047282.19181289
13Mismatch repair_Homo sapiens_hsa034302.08972413
14Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030082.04387298
15Renin secretion_Homo sapiens_hsa049241.98060320
16Oxytocin signaling pathway_Homo sapiens_hsa049211.92334149
17Cholinergic synapse_Homo sapiens_hsa047251.84081349
18Calcium signaling pathway_Homo sapiens_hsa040201.83429976
19Serotonergic synapse_Homo sapiens_hsa047261.81143400
20Taste transduction_Homo sapiens_hsa047421.80983529
21Insulin secretion_Homo sapiens_hsa049111.80843707
22Gastric acid secretion_Homo sapiens_hsa049711.80405357
23Aldosterone synthesis and secretion_Homo sapiens_hsa049251.79040721
24Long-term depression_Homo sapiens_hsa047301.77955968
25Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa049611.72117112
26RNA transport_Homo sapiens_hsa030131.68420940
27Parkinsons disease_Homo sapiens_hsa050121.66378918
28Adrenergic signaling in cardiomyocytes_Homo sapiens_hsa042611.66178303
29Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002501.64963398
30Collecting duct acid secretion_Homo sapiens_hsa049661.64686716
31Basal transcription factors_Homo sapiens_hsa030221.63962533
32DNA replication_Homo sapiens_hsa030301.62218251
33Cocaine addiction_Homo sapiens_hsa050301.60420760
34RNA polymerase_Homo sapiens_hsa030201.54956363
35Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa009701.52252031
36Cell cycle_Homo sapiens_hsa041101.49334680
37GnRH signaling pathway_Homo sapiens_hsa049121.44862260
38Ribosome_Homo sapiens_hsa030101.44368258
39Pyruvate metabolism_Homo sapiens_hsa006201.41318809
40cAMP signaling pathway_Homo sapiens_hsa040241.38637588
41Vitamin B6 metabolism_Homo sapiens_hsa007501.37734359
42RNA degradation_Homo sapiens_hsa030181.35824135
43mRNA surveillance pathway_Homo sapiens_hsa030151.35670421
44Huntingtons disease_Homo sapiens_hsa050161.35084168
45Cysteine and methionine metabolism_Homo sapiens_hsa002701.33626233
46Hippo signaling pathway_Homo sapiens_hsa043901.29600437
47Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa047501.29582317
48Gap junction_Homo sapiens_hsa045401.29561968
49Spliceosome_Homo sapiens_hsa030401.29183148
50Homologous recombination_Homo sapiens_hsa034401.27922861
51Propanoate metabolism_Homo sapiens_hsa006401.24142461
52Protein export_Homo sapiens_hsa030601.23423600
53Proteasome_Homo sapiens_hsa030501.21857134
54Axon guidance_Homo sapiens_hsa043601.19725028
55Basal cell carcinoma_Homo sapiens_hsa052171.19558261
56cGMP-PKG signaling pathway_Homo sapiens_hsa040221.18621429
57Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa005341.18528452
58Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa049601.17888644
59Neuroactive ligand-receptor interaction_Homo sapiens_hsa040801.17481603
60Non-homologous end-joining_Homo sapiens_hsa034501.16118818
61Phosphatidylinositol signaling system_Homo sapiens_hsa040701.14382022
62Citrate cycle (TCA cycle)_Homo sapiens_hsa000201.14359140
63Nucleotide excision repair_Homo sapiens_hsa034201.10835736
64Tight junction_Homo sapiens_hsa045301.09576241
65One carbon pool by folate_Homo sapiens_hsa006701.09317636
66Type II diabetes mellitus_Homo sapiens_hsa049301.08981018
67Cardiac muscle contraction_Homo sapiens_hsa042601.08761120
68Glioma_Homo sapiens_hsa052141.08482425
69ErbB signaling pathway_Homo sapiens_hsa040121.08326143
70Terpenoid backbone biosynthesis_Homo sapiens_hsa009001.07792345
71Estrogen signaling pathway_Homo sapiens_hsa049151.06676981
72Adherens junction_Homo sapiens_hsa045201.05557969
73Dilated cardiomyopathy_Homo sapiens_hsa054141.02710987
74Vascular smooth muscle contraction_Homo sapiens_hsa042701.00725779
75Melanogenesis_Homo sapiens_hsa049161.00319446
762-Oxocarboxylic acid metabolism_Homo sapiens_hsa012100.96648375
77Hedgehog signaling pathway_Homo sapiens_hsa043400.96647756
78Fanconi anemia pathway_Homo sapiens_hsa034600.92310029
79Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa051200.91319798
80Ubiquitin mediated proteolysis_Homo sapiens_hsa041200.91250429
81Vibrio cholerae infection_Homo sapiens_hsa051100.90160998
82Glycine, serine and threonine metabolism_Homo sapiens_hsa002600.89958393
83Phototransduction_Homo sapiens_hsa047440.87283226
84Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa045500.86386748
85Vasopressin-regulated water reabsorption_Homo sapiens_hsa049620.84064175
86Amyotrophic lateral sclerosis (ALS)_Homo sapiens_hsa050140.82609067
87MAPK signaling pathway_Homo sapiens_hsa040100.82415295
88Selenocompound metabolism_Homo sapiens_hsa004500.81509064
89Dorso-ventral axis formation_Homo sapiens_hsa043200.80568789
90Pancreatic secretion_Homo sapiens_hsa049720.78029164
91Oocyte meiosis_Homo sapiens_hsa041140.78004753
92Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006300.76544308
93Circadian rhythm_Homo sapiens_hsa047100.76302090
94Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006040.75914869
95Synthesis and degradation of ketone bodies_Homo sapiens_hsa000720.73100673
96Arginine and proline metabolism_Homo sapiens_hsa003300.73001856
97African trypanosomiasis_Homo sapiens_hsa051430.72747313
98TGF-beta signaling pathway_Homo sapiens_hsa043500.72531578
99Steroid biosynthesis_Homo sapiens_hsa001000.72260330
100Choline metabolism in cancer_Homo sapiens_hsa052310.71548243
101Folate biosynthesis_Homo sapiens_hsa007900.70813351
102Purine metabolism_Homo sapiens_hsa002300.70402334
103VEGF signaling pathway_Homo sapiens_hsa043700.68735880
104Phospholipase D signaling pathway_Homo sapiens_hsa040720.66682752
105Arrhythmogenic right ventricular cardiomyopathy (ARVC)_Homo sapiens_hsa054120.65756943
106Hypertrophic cardiomyopathy (HCM)_Homo sapiens_hsa054100.65570713
107Regulation of lipolysis in adipocytes_Homo sapiens_hsa049230.64254009
108Glucagon signaling pathway_Homo sapiens_hsa049220.63010852
109Ras signaling pathway_Homo sapiens_hsa040140.61289338
110Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049640.59632667
111Thyroid hormone synthesis_Homo sapiens_hsa049180.58858428
112Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049320.58380962
113Base excision repair_Homo sapiens_hsa034100.57416577
114Rap1 signaling pathway_Homo sapiens_hsa040150.56897127
115Alzheimers disease_Homo sapiens_hsa050100.56778045
116Neurotrophin signaling pathway_Homo sapiens_hsa047220.55452939
117Biosynthesis of amino acids_Homo sapiens_hsa012300.54970769
118Type I diabetes mellitus_Homo sapiens_hsa049400.54896315
119Thyroid cancer_Homo sapiens_hsa052160.54730637
120Carbon metabolism_Homo sapiens_hsa012000.50863254
121Sphingolipid signaling pathway_Homo sapiens_hsa040710.48818627
122Wnt signaling pathway_Homo sapiens_hsa043100.48779794
123Valine, leucine and isoleucine degradation_Homo sapiens_hsa002800.48001497
124Cell adhesion molecules (CAMs)_Homo sapiens_hsa045140.47447729
125Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005330.46950993
126Inositol phosphate metabolism_Homo sapiens_hsa005620.46774123
127Arginine biosynthesis_Homo sapiens_hsa002200.46702114
128Alcoholism_Homo sapiens_hsa050340.46581704
129mTOR signaling pathway_Homo sapiens_hsa041500.45865634
130Rheumatoid arthritis_Homo sapiens_hsa053230.44917746
131Longevity regulating pathway - mammal_Homo sapiens_hsa042110.41462435
132Renal cell carcinoma_Homo sapiens_hsa052110.39908421
133Chemokine signaling pathway_Homo sapiens_hsa040620.38889368
134Thyroid hormone signaling pathway_Homo sapiens_hsa049190.37855278
135Non-small cell lung cancer_Homo sapiens_hsa052230.35843024
136Longevity regulating pathway - multiple species_Homo sapiens_hsa042130.34933418
137Natural killer cell mediated cytotoxicity_Homo sapiens_hsa046500.34627818
138Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004000.34565313
139Insulin signaling pathway_Homo sapiens_hsa049100.34027785
140Regulation of actin cytoskeleton_Homo sapiens_hsa048100.33884978
141Carbohydrate digestion and absorption_Homo sapiens_hsa049730.33533895
142Ovarian steroidogenesis_Homo sapiens_hsa049130.32948462
143Prion diseases_Homo sapiens_hsa050200.32140972
144Progesterone-mediated oocyte maturation_Homo sapiens_hsa049140.28001033
145Oxidative phosphorylation_Homo sapiens_hsa001900.27312179
146Endometrial cancer_Homo sapiens_hsa052130.26742536
147Other types of O-glycan biosynthesis_Homo sapiens_hsa005140.24806849
148Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006030.24656519
149Endocytosis_Homo sapiens_hsa041440.24339792
150Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005120.24112138
151Platelet activation_Homo sapiens_hsa046110.23117898
152Tuberculosis_Homo sapiens_hsa051520.22804469

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