ARCHS4

Functional Annotation Prediction

Predicted biological processes (GO)

Rank	Gene Set	Z-score
1	chromosome condensation (GO:0030261)	9.59673109
2	DNA packaging (GO:0006323)	9.25704800
3	sperm capacitation (GO:0048240)	8.78202220
4	response to pheromone (GO:0019236)	8.74247470
5	microtubule depolymerization (GO:0007019)	8.72879124
6	plasma membrane fusion (GO:0045026)	8.49135051
7	spermatid development (GO:0007286)	8.44501218
8	spermatid nucleus differentiation (GO:0007289)	7.75184482
9	sperm-egg recognition (GO:0035036)	7.74519621
10	single strand break repair (GO:0000012)	7.58041397
11	binding of sperm to zona pellucida (GO:0007339)	7.48543390
12	multicellular organism reproduction (GO:0032504)	7.13308541
13	negative regulation of inclusion body assembly (GO:0090084)	6.94316162
14	microtubule polymerization or depolymerization (GO:0031109)	6.90029346
15	reproduction (GO:0000003)	6.65383220
16	rRNA methylation (GO:0031167)	6.54424770
17	calcium ion-dependent exocytosis (GO:0017156)	6.48516492
18	spermatogenesis (GO:0007283)	6.38596393
19	male gamete generation (GO:0048232)	6.36661952
20	cell-cell recognition (GO:0009988)	6.35078687
21	sexual reproduction (GO:0019953)	6.27258768
22	protein polyglutamylation (GO:0018095)	6.07822015
23	gamete generation (GO:0007276)	5.87036683
24	microtubule severing (GO:0051013)	5.73495873
25	axonemal dynein complex assembly (GO:0070286)	5.69676388
26	protein targeting to Golgi (GO:0000042)	5.69147443
27	phosphatidylethanolamine biosynthetic process (GO:0006646)	5.62665684
28	cellular ketone body metabolic process (GO:0046950)	5.53617069
29	rRNA modification (GO:0000154)	5.50497308
30	establishment of protein localization to Golgi (GO:0072600)	5.48453847
31	retrograde transport, vesicle recycling within Golgi (GO:0000301)	5.26802279
32	phosphatidylethanolamine metabolic process (GO:0046337)	5.23759091
33	centriole replication (GO:0007099)	5.18971883
34	germ cell development (GO:0007281)	4.94111776
35	centriole assembly (GO:0098534)	4.89688263
36	antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-independent (G	4.87743377
37	single fertilization (GO:0007338)	4.87628865
38	ketone body metabolic process (GO:1902224)	4.87246991
39	positive regulation of Rab GTPase activity (GO:0032851)	4.87154247
40	regulation of Rab GTPase activity (GO:0032313)	4.87154247
41	regulation of inclusion body assembly (GO:0090083)	4.83936788
42	histone H3-K9 demethylation (GO:0033169)	4.79928770
43	regulation of cilium movement (GO:0003352)	4.77293227
44	chromatin silencing (GO:0006342)	4.75742222
45	multicellular organismal reproductive process (GO:0048609)	4.70002513
46	male meiosis I (GO:0007141)	4.65411072
47	motile cilium assembly (GO:0044458)	4.64405310
48	cellular process involved in reproduction in multicellular organism (GO:0022412)	4.63693389
49	piRNA metabolic process (GO:0034587)	4.54699068
50	cilium or flagellum-dependent cell motility (GO:0001539)	4.53991919
51	fertilization (GO:0009566)	4.39040105
52	RNA destabilization (GO:0050779)	4.35789487
53	nucleus organization (GO:0006997)	4.33405222
54	regulation of centriole replication (GO:0046599)	4.20293385
55	gonadal mesoderm development (GO:0007506)	4.09867295
56	protein localization to Golgi apparatus (GO:0034067)	4.07099384
57	regulation of transcription involved in cell fate commitment (GO:0060850)	4.04852968
58	male meiosis (GO:0007140)	4.03561658
59	DNA methylation involved in gamete generation (GO:0043046)	4.01004677
60	cell wall macromolecule catabolic process (GO:0016998)	3.93650673
61	coenzyme catabolic process (GO:0009109)	3.88737654
62	epithelial cilium movement (GO:0003351)	3.83268568
63	negative regulation of Rho protein signal transduction (GO:0035024)	3.62189490
64	seminiferous tubule development (GO:0072520)	3.60973068
65	regulation of microtubule-based movement (GO:0060632)	3.60734377
66	cell wall macromolecule metabolic process (GO:0044036)	3.60074514
67	meiosis I (GO:0007127)	3.59978017
68	synaptonemal complex assembly (GO:0007130)	3.56020395
69	chromosome organization involved in meiosis (GO:0070192)	3.54490004
70	glycerol ether metabolic process (GO:0006662)	3.52859522
71	response to acidic pH (GO:0010447)	3.47368185
72	organic cation transport (GO:0015695)	3.45611314
73	peptidyl-threonine dephosphorylation (GO:0035970)	3.44021747
74	cerebral cortex neuron differentiation (GO:0021895)	3.38824398
75	cilium movement (GO:0003341)	3.37098048
76	cellular response to pH (GO:0071467)	3.36468020
77	synapsis (GO:0007129)	3.32498718
78	microtubule nucleation (GO:0007020)	3.32100156
79	negative regulation of gene expression, epigenetic (GO:0045814)	3.29148388
80	polyamine biosynthetic process (GO:0006596)	3.26454436
81	membrane protein intracellular domain proteolysis (GO:0031293)	3.25425940
82	ether metabolic process (GO:0018904)	3.24204390
83	musculoskeletal movement (GO:0050881)	3.23417088
84	multicellular organismal movement (GO:0050879)	3.23417088
85	protein depolymerization (GO:0051261)	3.20492604
86	DNA conformation change (GO:0071103)	3.19560862
87	meiotic nuclear division (GO:0007126)	3.17691969
88	synaptonemal complex organization (GO:0070193)	3.13278105
89	protein-DNA complex disassembly (GO:0032986)	3.12500342
90	nucleosome disassembly (GO:0006337)	3.12500342
91	negative regulation of histone methylation (GO:0031061)	3.08393220
92	homeostasis of number of cells within a tissue (GO:0048873)	3.05104248
93	multicellular organismal development (GO:0007275)	3.04695801
94	regulation of somitogenesis (GO:0014807)	3.04660998
95	gene silencing (GO:0016458)	2.99133615
96	cell recognition (GO:0008037)	2.96225138
97	glomerular visceral epithelial cell development (GO:0072015)	2.93483977
98	acrosome reaction (GO:0007340)	11.9776559
99	fusion of sperm to egg plasma membrane (GO:0007342)	11.2451678
100	sperm motility (GO:0030317)	10.8509762

Predicted upstream transcription factors (ChEA)

Rank	Gene Set	Z-score
1	TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat	4.70882577
2	SOX9_22984422_ChIP-ChIP_TESTIS_Rat	3.73894791
3	MYCN_19997598_ChIP-ChIP_NEUROBLASTOMA_Human	3.57562336
4	EZH2_22144423_ChIP-Seq_EOC_Human	2.94249738
5	TEAD4_26923725_Chip-Seq_HEMANGIOBLAST_Mouse	2.51980622
6	POU5F1_26923725_Chip-Seq_MESODERM_Mouse	2.51980622
7	ELF1_20517297_ChIP-Seq_JURKAT_Human	2.27936429
8	VDR_20736230_ChIP-Seq_LYMPHOBLASTOID_Human	2.22167631
9	MYCN_21190229_ChIP-Seq_SHEP-21N_Human	2.21532662
10	CTBP2_25329375_ChIP-Seq_LNCAP_Human	2.17612630
11	CBP_20019798_ChIP-Seq_JUKART_Human	2.11633954
12	IRF4_20064451_ChIP-Seq_CD4+T_Mouse	2.11633954
13	ERA_21632823_ChIP-Seq_H3396_Human	2.04376368
14	CTBP1_25329375_ChIP-Seq_LNCAP_Human	2.03463627
15	RAC3_21632823_ChIP-Seq_H3396_Human	2.00629500
16	YY1_22570637_ChIP-Seq_MALME-3M_Human	1.92307839
17	FUS_26573619_Chip-Seq_HEK293_Human	1.88533005
18	RBPJ_21746931_ChIP-Seq_IB4-LCL_Human	1.87164339
19	STAT6_21828071_ChIP-Seq_BEAS2B_Human	1.85176594
20	EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human	1.83519997
21	NANOG_20526341_ChIP-Seq_ESCs_Human	1.82191242
22	EBNA1_20929547_Chip-Seq_RAJI-cells_Human	1.81798163
23	WDR5_24793694_ChIP-Seq_LNCAP_Human	1.80845529
24	EBNA2_21746931_ChIP-Seq_IB4-LCL_Human	1.80329988
25	E2F1_20622854_ChIP-Seq_HELA_Human	1.78381745
26	BCL6_27268052_Chip-Seq_Bcells_Human	1.77313346
27	CTCF_27219007_Chip-Seq_Bcells_Human	1.75129265
28	UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human	1.73906556
29	TAF2_19829295_ChIP-Seq_ESCs_Human	1.72826885
30	TP63_19390658_ChIP-ChIP_HaCaT_Human	1.70061901
31	TDRD3_21172665_ChIP-Seq_MCF-7_Human	1.67579868
32	MYC_19829295_ChIP-Seq_ESCs_Human	1.67362985
33	P68_20966046_ChIP-Seq_HELA_Human	1.66149677
34	SMC4_20622854_ChIP-Seq_HELA_Human	1.65238394
35	BCOR_27268052_Chip-Seq_Bcells_Human	1.64506627
36	PHF8_20622854_ChIP-Seq_HELA_Human	1.64128758
37	DROSHA_22980978_ChIP-Seq_HELA_Human	1.59792270
38	AUTS2_25519132_ChIP-Seq_293T-REX_Human	1.57939023
39	ER_23166858_ChIP-Seq_MCF-7_Human	1.57659563
40	TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse	1.55710966
41	SMAD4_21741376_ChIP-Seq_EPCs_Human	1.54027254
42	MYBL1_21750041_ChIP-ChIP_SPERMATOCYTES_Mouse	1.50615344
43	PPARD_23208498_ChIP-Seq_MDA-MB-231_Human	1.48606346
44	TAF15_26573619_Chip-Seq_HEK293_Human	1.47695289
45	TP63_22573176_ChIP-Seq_HFKS_Human	1.47678923
46	CTCF_20526341_ChIP-Seq_ESCs_Human	1.47569001
47	OCT4_20526341_ChIP-Seq_ESCs_Human	1.46721397
48	AR_25329375_ChIP-Seq_VCAP_Human	1.45383344
49	P300_27268052_Chip-Seq_Bcells_Human	1.45196868
50	ARNT_22903824_ChIP-Seq_MCF-7_Human	1.40415756
51	RUNX_20019798_ChIP-Seq_JUKART_Human	1.40234969
52	RUNX1_26923725_Chip-Seq_HPCs_Mouse	1.38385472
53	HNFA_21074721_ChIP-Seq_CACO-2_Human	1.35449366
54	SMAD2/3_21741376_ChIP-Seq_ESCs_Human	1.35308384
55	GATA3_21878914_ChIP-Seq_MCF-7_Human	1.34491448
56	SMAD2/3_21741376_ChIP-Seq_EPCs_Human	1.33858443
57	CBX2_22325352_ChIP-Seq_293T-Rex_Human	1.33453931
58	RBPJ_21746931_ChIP-Seq_IB4_Human	1.32468148
59	CDX2_21074721_ChIP-Seq_CACO-2_Mouse	1.28111340
60	ETV1_20927104_ChIP-Seq_GIST48_Human	1.27734854
61	ERG_20517297_ChIP-Seq_VCAP_Human	1.27684797
62	CREM_20920259_ChIP-Seq_GC1-SPG_Mouse	1.27565778
63	ETV2_25802403_ChIP-Seq_MESCs_Mouse	1.27453143
64	P63_20808887_ChIP-Seq_KERATINOCYTES_Human	1.26052022
65	LXR_22292898_ChIP-Seq_THP-1_Human	1.25000729
66	TOP2B_26459242_ChIP-Seq_MCF-7_Human	1.24867515
67	P53_21459846_ChIP-Seq_SAOS-2_Human	1.24754193
68	SCL_21571218_ChIP-Seq_MEGAKARYOCYTES_Human	1.24744052
69	SMAD3_21741376_ChIP-Seq_ESCs_Human	1.22777272
70	SMAD3_21741376_ChIP-Seq_EPCs_Human	1.20064272
71	VDR_22108803_ChIP-Seq_LS180_Human	1.19727906
72	KLF1_20508144_ChIP-Seq_FETAL-LIVER-ERYTHROID_Mouse	1.19181455
73	RUNX2_22187159_ChIP-Seq_PCA_Human	1.19133976
74	SOX2_22085726_ChIP-Seq_NPCs_Mouse	1.18583287
75	NFYB_21822215_ChIP-Seq_K562_Human	1.17827846
76	NR4A2_19515692_ChIP-ChIP_MN9D_Mouse	1.17701979
77	CEBPB_22108803_ChIP-Seq_LS180_Human	1.17169065
78	SMRT_27268052_Chip-Seq_Bcells_Human	1.16867337
79	ERA_27197147_Chip-Seq_ENDOMETRIOID-ADENOCARCINOMA_Human	1.16465425
80	GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse	1.16387844
81	ZFP322A_24550733_ChIP-Seq_MESCs_Mouse	1.15011335
82	PBX1_22567123_ChIP-ChIP_OVCAR3_Human	1.13823100
83	TBL1_22424771_ChIP-Seq_293T_Human	1.13796882
84	KLF5_20875108_ChIP-Seq_MESCs_Mouse	1.13751327
85	ZNF274_21170338_ChIP-Seq_K562_Hela	1.13588040
86	SUZ12_27294783_Chip-Seq_ESCs_Mouse	1.12418028
87	SMAD4_21741376_ChIP-Seq_HESCs_Human	1.12022746
88	GATA3_26560356_Chip-Seq_TH1_Human	1.11732611
89	P300_19829295_ChIP-Seq_ESCs_Human	1.11564956
90	HOXB7_26014856_ChIP-Seq_BT474_Human	1.11204216
91	TP53_18474530_ChIP-ChIP_U2OS_Human	1.10943506
92	E2F1_17053090_ChIP-ChIP_MCF-7_Human	1.10370371
93	PHF8_20622853_ChIP-Seq_HELA_Human	1.09557610
94	OCT1_27270436_Chip-Seq_PROSTATE_Human	1.07782561
95	SA1_27219007_Chip-Seq_Bcells_Human	1.03722812
96	GATA6_21074721_ChIP-Seq_CACO-2_Human	1.03027150
97	EWS-FLI1_20517297_ChIP-Seq_SK-N-MC_Human	1.00651016
98	NANOG_19829295_ChIP-Seq_ESCs_Human	1.00289173
99	SOX2_19829295_ChIP-Seq_ESCs_Human	1.00289173
100	FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse	0.99713639

Predicted mouse phenotypes (MGI)

Rank	Gene Set	Z-score
1	MP0003698_abnormal_male_reproductive	4.98928447
2	MP0001929_abnormal_gametogenesis	4.60404442
3	MP0005377_hearing/vestibular/ear_phenot	4.23477393
4	MP0003878_abnormal_ear_physiology	4.23477393
5	MP0005670_abnormal_white_adipose	4.05538632
6	MP0001348_abnormal_lacrimal_gland	3.00595848
7	MP0000678_abnormal_parathyroid_gland	2.93952745
8	MP0002161_abnormal_fertility/fecundity	2.88672617
9	MP0003718_maternal_effect	2.65761374
10	MP0002210_abnormal_sex_determination	2.59884197
11	MP0008877_abnormal_DNA_methylation	2.49858371
12	MP0003646_muscle_fatigue	2.46228628
13	MP0002132_abnormal_respiratory_system	2.07312504
14	MP0001145_abnormal_male_reproductive	2.06912301
15	MP0005410_abnormal_fertilization	12.2074543
16	MP0003011_delayed_dark_adaptation	1.98233096
17	MP0000653_abnormal_sex_gland	1.95560066
18	MP0002234_abnormal_pharynx_morphology	1.85611534
19	MP0005423_abnormal_somatic_nervous	1.83313991
20	MP0002249_abnormal_larynx_morphology	1.58439359
21	MP0005310_abnormal_salivary_gland	1.57967966
22	MP0005379_endocrine/exocrine_gland_phen	1.54029175
23	MP0008995_early_reproductive_senescence	1.51562162
24	MP0009053_abnormal_anal_canal	1.39251991
25	MP0001765_abnormal_ion_homeostasis	1.26881422
26	MP0001968_abnormal_touch/_nociception	1.25333979
27	MP0004742_abnormal_vestibular_system	1.21620600
28	MP0004510_myositis	1.21509423
29	MP0001486_abnormal_startle_reflex	1.20805467
30	MP0002282_abnormal_trachea_morphology	1.18268434
31	MP0001485_abnormal_pinna_reflex	1.17127019
32	MP0003879_abnormal_hair_cell	1.08060990
33	MP0005395_other_phenotype	1.07497131
34	MP0000534_abnormal_ureter_morphology	1.02354486
35	MP0002735_abnormal_chemical_nociception	1.02191881
36	MP0002138_abnormal_hepatobiliary_system	1.01697329
37	MP0003693_abnormal_embryo_hatching	1.01485393
38	MP0001963_abnormal_hearing_physiology	1.00496080
39	MP0002127_abnormal_cardiovascular_syste	0.99322092
40	MP0003077_abnormal_cell_cycle	0.97874338
41	MP0006292_abnormal_olfactory_placode	0.97817110
42	MP0003699_abnormal_female_reproductive	0.92224197
43	MP0000681_abnormal_thyroid_gland	0.90800104
44	MP0000026_abnormal_inner_ear	0.87821603
45	MP0002229_neurodegeneration	0.80541778
46	MP0005451_abnormal_body_composition	0.78937181
47	MP0003136_yellow_coat_color	0.78147362
48	MP0000955_abnormal_spinal_cord	0.77689592
49	MP0004859_abnormal_synaptic_plasticity	0.73303649
50	MP0002733_abnormal_thermal_nociception	0.73142064
51	MP0002067_abnormal_sensory_capabilities	0.70600834
52	MP0005666_abnormal_adipose_tissue	0.67957861
53	MP0000049_abnormal_middle_ear	0.66364140
54	MP0008569_lethality_at_weaning	0.65449827
55	MP0004233_abnormal_muscle_weight	0.64433700
56	MP0009115_abnormal_fat_cell	0.64418390
57	MP0005551_abnormal_eye_electrophysiolog	0.64216003
58	MP0002160_abnormal_reproductive_system	0.63872771
59	MP0005636_abnormal_mineral_homeostasis	0.63846767
60	MP0005083_abnormal_biliary_tract	0.62523572
61	MP0004085_abnormal_heartbeat	0.62014902
62	MP0002822_catalepsy	0.61938664
63	MP0001666_abnormal_nutrient_absorption	0.60960849
64	MP0008789_abnormal_olfactory_epithelium	0.60190186
65	MP0001119_abnormal_female_reproductive	0.59970533
66	MP0003119_abnormal_digestive_system	0.59147049
67	MP0002928_abnormal_bile_duct	0.56219665
68	MP0005647_abnormal_sex_gland	0.54117656
69	MP0003936_abnormal_reproductive_system	0.54019987
70	MP0002557_abnormal_social/conspecific_i	0.53958325
71	MP0002272_abnormal_nervous_system	0.51809251
72	MP0005248_abnormal_Harderian_gland	0.51510642
73	MP0005375_adipose_tissue_phenotype	0.51205482
74	MP0004957_abnormal_blastocyst_morpholog	0.49783271
75	MP0004036_abnormal_muscle_relaxation	0.49218412
76	MP0000003_abnormal_adipose_tissue	0.46597401
77	MP0001879_abnormal_lymphatic_vessel	0.45286424
78	MP0005394_taste/olfaction_phenotype	0.43947822
79	MP0005499_abnormal_olfactory_system	0.43947822
80	MP0000470_abnormal_stomach_morphology	0.42922047
81	MP0001970_abnormal_pain_threshold	0.42680438
82	MP0009697_abnormal_copulation	0.42437720
83	MP0005253_abnormal_eye_physiology	0.41370349
84	MP0002572_abnormal_emotion/affect_behav	0.38967905
85	MP0003172_abnormal_lysosome_physiology	0.38811696
86	MP0001905_abnormal_dopamine_level	0.38157365
87	MP0001873_stomach_inflammation	0.38008605
88	MP0003959_abnormal_lean_body	0.36365953
89	MP0008058_abnormal_DNA_repair	0.35237297
90	MP0002653_abnormal_ependyma_morphology	0.34438053
91	MP0000313_abnormal_cell_death	0.32989771
92	MP0000015_abnormal_ear_pigmentation	0.32870519
93	MP0005645_abnormal_hypothalamus_physiol	0.32495729
94	MP0002734_abnormal_mechanical_nocicepti	0.32216737
95	MP0005535_abnormal_body_temperature	0.32080301
96	MP0009745_abnormal_behavioral_response	0.32073278
97	MP0000566_synostosis	0.32022869
98	MP0005408_hypopigmentation	0.31580435
99	MP0001984_abnormal_olfaction	0.30856615
100	MP0000249_abnormal_blood_vessel	0.30711662

Predicted human phenotypes

Rank	Gene Set	Z-score
1	Severe visual impairment (HP:0001141)	8.43237362
2	Absent/shortened dynein arms (HP:0200106)	5.62529749
3	Dynein arm defect of respiratory motile cilia (HP:0012255)	5.62529749
4	Bony spicule pigmentary retinopathy (HP:0007737)	5.07741357
5	Attenuation of retinal blood vessels (HP:0007843)	5.06943633
6	Tubulointerstitial nephritis (HP:0001970)	4.85590977
7	Asymmetric septal hypertrophy (HP:0001670)	4.67416158
8	Bell-shaped thorax (HP:0001591)	4.57311859
9	Parkinsonism with favorable response to dopaminergic medication (HP:0002548)	4.53147353
10	Azoospermia (HP:0000027)	4.48370290
11	Resting tremor (HP:0002322)	4.46188847
12	Abnormal ciliary motility (HP:0012262)	4.43551092
13	Enlarged epiphyses (HP:0010580)	4.35901278
14	Male infertility (HP:0003251)	4.27346011
15	Abnormal respiratory motile cilium physiology (HP:0012261)	4.27175735
16	Infertility (HP:0000789)	4.22860711
17	Hyperkalemia (HP:0002153)	4.22353301
18	Hypoplastic ischia (HP:0003175)	4.13758931
19	Abnormal rod and cone electroretinograms (HP:0008323)	4.10591877
20	Abnormal respiratory epithelium morphology (HP:0012253)	4.08535801
21	Abnormal respiratory motile cilium morphology (HP:0005938)	4.08535801
22	Abnormal spermatogenesis (HP:0008669)	4.05718687
23	Chronic hepatic failure (HP:0100626)	3.94085526
24	Nasal polyposis (HP:0100582)	3.88832623
25	Abnormality of macular pigmentation (HP:0008002)	3.81127067
26	Potter facies (HP:0002009)	3.73147131
27	Facial shape deformation (HP:0011334)	3.73147131
28	Aplasia/Hypoplasia of the earlobes (HP:0009906)	3.69256321
29	Abnormality of the ischium (HP:0003174)	3.63342034
30	Respiratory insufficiency due to defective ciliary clearance (HP:0200073)	3.61694236
31	Impulsivity (HP:0100710)	3.50742992
32	Osteomalacia (HP:0002749)	3.41877922
33	Cone-rod dystrophy (HP:0000548)	3.35920756
34	Aplasia/Hypoplasia of the pubic bone (HP:0009104)	3.31455867
35	Abnormality of the nasal mucosa (HP:0000433)	3.05694780
36	Unilateral renal agenesis (HP:0000122)	3.05677314
37	Truncal obesity (HP:0001956)	2.85474009
38	Double outlet right ventricle (HP:0001719)	2.82438223
39	Congenital malformation of the right heart (HP:0011723)	2.82438223
40	Hypoplasia of the thymus (HP:0000778)	2.79820245
41	Generalized aminoaciduria (HP:0002909)	2.74098318
42	Postural instability (HP:0002172)	2.67399725
43	Nephronophthisis (HP:0000090)	2.67143353
44	Horizontal nystagmus (HP:0000666)	2.64280657
45	Abnormality of the aortic arch (HP:0012303)	2.59015255
46	Progressive sensorineural hearing impairment (HP:0000408)	2.57722201
47	Stage 5 chronic kidney disease (HP:0003774)	2.53118917
48	Flattened epiphyses (HP:0003071)	2.52575907
49	Abnormal urine output (HP:0012590)	2.50972769
50	Rhinitis (HP:0012384)	2.49113823
51	Progressive hearing impairment (HP:0001730)	2.48022486
52	Renal dysplasia (HP:0000110)	2.45224031
53	Tubulointerstitial abnormality (HP:0001969)	2.44209904
54	Abnormality of the costochondral junction (HP:0000919)	2.37624573
55	Abnormality of potassium homeostasis (HP:0011042)	2.37470112
56	Aplasia/Hypoplasia of the capital femoral epiphysis (HP:0005003)	2.34022456
57	Absent epiphyses (HP:0010577)	2.34022456
58	Abnormality of the renal medulla (HP:0100957)	2.32790864
59	Hypophosphatemic rickets (HP:0004912)	2.31871178
60	Epiphyseal dysplasia (HP:0002656)	2.31815220
61	Hypoalphalipoproteinemia (HP:0003233)	2.30224811
62	Abnormality of renal excretion (HP:0011036)	2.26665746
63	Abnormal drinking behavior (HP:0030082)	2.18106766
64	Polydipsia (HP:0001959)	2.18106766
65	Progressive cerebellar ataxia (HP:0002073)	2.17948110
66	Menstrual irregularities (HP:0000858)	2.17759707
67	Abnormality of the parathyroid morphology (HP:0011766)	2.17178056
68	Abnormality of the pubic bones (HP:0003172)	2.15807098
69	Bowel incontinence (HP:0002607)	2.10942635
70	Ventricular tachycardia (HP:0004756)	2.09708779
71	Hypoparathyroidism (HP:0000829)	2.07433035
72	Insulin-resistant diabetes mellitus (HP:0000831)	2.07311723
73	Amelogenesis imperfecta (HP:0000705)	2.06228797
74	Upper limb muscle weakness (HP:0003484)	2.05381706
75	Portal hypertension (HP:0001409)	2.05277397
76	Abnormality of the epiphysis of the femoral head (HP:0010574)	2.04934191
77	Renovascular hypertension (HP:0100817)	2.04167566
78	Abnormality of dental color (HP:0011073)	1.98683001
79	Polyuria (HP:0000103)	1.96760525
80	Tetany (HP:0001281)	1.94450321
81	Hyponatremia (HP:0002902)	1.93824963
82	Abnormal large intestine physiology (HP:0012700)	1.93209487
83	Bronchiectasis (HP:0002110)	1.90207245
84	Abnormality of the hepatic vasculature (HP:0006707)	1.89337628
85	Abnormality of femoral epiphyses (HP:0006499)	1.87586208
86	Abnormality involving the epiphyses of the lower limbs (HP:0006500)	1.87586208
87	Hyperthyroidism (HP:0000836)	1.87521662
88	Flat capital femoral epiphysis (HP:0003370)	1.87423862
89	Short ribs (HP:0000773)	1.86756473
90	Decreased central vision (HP:0007663)	1.85129618
91	Focal segmental glomerulosclerosis (HP:0000097)	1.82926315
92	Aplasia/Hypoplasia of the sacrum (HP:0008517)	1.80553170
93	Abnormality of the femoral head (HP:0003368)	1.79197690
94	Protuberant abdomen (HP:0001538)	1.78361156
95	Transposition of the great arteries (HP:0001669)	1.77377317
96	Abnormal connection of the cardiac segments (HP:0011545)	1.77377317
97	Abnormal ventriculo-arterial connection (HP:0011563)	1.77377317
98	Peripheral hypomyelination (HP:0007182)	1.75832149
99	Atelectasis (HP:0100750)	1.75201523
100	Widely patent fontanelles and sutures (HP:0004492)	1.74999029

Predicted kinase interactions (KEA)

Rank	Gene Set	Z-score
1	PLK4	7.57310036
2	TESK1	5.50098312
3	DDR2	5.00835483
4	PNCK	4.70893344
5	INSRR	4.12554585
6	MAP4K2	3.52844448
7	PLK2	3.06145060
8	STK38	2.87926675
9	BRD4	2.66759630
10	CAMK1G	2.65166654
11	PRKD3	2.08876081
12	MAPK15	2.06664260
13	STK38L	2.00104060
14	WNK1	1.80841595
15	CDK12	1.79252244
16	MST1R	1.68844309
17	CDK7	1.68175247
18	PTK2B	1.62505580
19	PDPK1	1.54535901
20	MET	1.52940617
21	MAP3K9	1.52184468
22	KSR2	1.45729871
23	PDK1	1.44803256
24	NEK6	1.41901862
25	PIK3CG	1.38813293
26	DYRK1B	1.17706909
27	BRAF	1.01906375
28	CDK3	0.89151600
29	MAP3K2	0.86042330
30	CDK4	0.85385408
31	CDK19	0.79647965
32	ARAF	0.78970522
33	MAP2K2	0.78522513
34	UHMK1	0.68933266
35	FRK	0.64578043
36	CAMK1	0.63442134
37	TYRO3	0.62188481
38	AKT3	0.61836720
39	MAP3K8	0.61824014
40	RPS6KA1	0.59353545
41	PRKG1	0.57929106
42	ICK	0.57780371
43	CDK2	0.55796631
44	CHEK1	0.52329348
45	WNK4	0.51927949
46	STK39	0.51467203
47	MAP3K13	0.51410863
48	ROCK1	0.51274750
49	CDK1	0.49045379
50	RPS6KA2	0.48290046
51	CAMK1D	0.47566638
52	LATS1	0.46347060
53	LATS2	0.45654230
54	GSK3B	0.44925478
55	PRKG2	0.43769564
56	PRKAA2	0.43574368
57	BMPR1B	0.41570761
58	SIK2	0.41294281
59	MTOR	0.40034315
60	MAPK1	0.39243313
61	MAP3K7	0.38660480
62	CSF1R	0.37294753
63	OXSR1	0.35376778
64	BRSK1	0.34712085
65	MARK2	0.34299926
66	RPS6KL1	0.33728423
67	RPS6KC1	0.33728423
68	ACVR1B	0.33703280
69	RPS6KA6	0.33015090
70	MAP3K11	0.31360856
71	PRKCZ	0.30171109
72	CDK8	0.29922855
73	MAPK8	0.27788841
74	CAMK4	0.27552465
75	MAPK11	0.27034036
76	BMX	0.27018174
77	MAP3K1	0.26568459
78	SGK1	0.25822190
79	MUSK	0.24875510
80	MAPK14	0.24696326
81	AURKA	0.23033256
82	MAPK10	0.22467269
83	PRKCG	0.21832140
84	NUAK1	0.21744497
85	SGK494	0.21303905
86	SGK223	0.21303905
87	RET	0.21193385
88	PLK1	0.19095920
89	TAF1	0.18189444
90	AKT1	0.16878480
91	NEK2	0.15420714
92	NTRK3	0.14172464
93	MAP3K4	0.13772417
94	PRKAA1	0.12537862
95	PRKCB	0.12058551
96	CDK9	0.11174054
97	PASK	0.11102543
98	TESK2	0.08680110
99	MAP2K1	0.08381140
100	PRKACB	0.08048078

Predicted pathways (KEGG)

Rank	Gene Set	Z-score
1	Synthesis and degradation of ketone bodies_Homo sapiens_hsa00072	7.95914284
2	Fatty acid biosynthesis_Homo sapiens_hsa00061	5.77542221
3	Olfactory transduction_Homo sapiens_hsa04740	3.82570015
4	Butanoate metabolism_Homo sapiens_hsa00650	2.62844953
5	Dorso-ventral axis formation_Homo sapiens_hsa04320	2.48232621
6	RNA transport_Homo sapiens_hsa03013	2.14164859
7	Glycerophospholipid metabolism_Homo sapiens_hsa00564	1.97665233
8	Taste transduction_Homo sapiens_hsa04742	1.82938607
9	Allograft rejection_Homo sapiens_hsa05330	1.70004636
10	Autoimmune thyroid disease_Homo sapiens_hsa05320	1.69385156
11	Antigen processing and presentation_Homo sapiens_hsa04612	1.66443114
12	Longevity regulating pathway - multiple species_Homo sapiens_hsa04213	1.62270915
13	Type I diabetes mellitus_Homo sapiens_hsa04940	1.60034606
14	Type II diabetes mellitus_Homo sapiens_hsa04930	1.59467452
15	Graft-versus-host disease_Homo sapiens_hsa05332	1.55302644
16	Phenylalanine metabolism_Homo sapiens_hsa00360	1.54977349
17	Progesterone-mediated oocyte maturation_Homo sapiens_hsa04914	1.49806534
18	Protein processing in endoplasmic reticulum_Homo sapiens_hsa04141	1.47244751
19	Oocyte meiosis_Homo sapiens_hsa04114	1.39028695
20	Butirosin and neomycin biosynthesis_Homo sapiens_hsa00524	1.25271309
21	Fatty acid metabolism_Homo sapiens_hsa01212	1.24626771
22	Viral myocarditis_Homo sapiens_hsa05416	1.23359772
23	Fatty acid degradation_Homo sapiens_hsa00071	1.21051673
24	Nicotinate and nicotinamide metabolism_Homo sapiens_hsa00760	1.20595899
25	Basal transcription factors_Homo sapiens_hsa03022	1.19379030
26	Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa04961	1.16488701
27	mRNA surveillance pathway_Homo sapiens_hsa03015	1.13477502
28	Arginine and proline metabolism_Homo sapiens_hsa00330	1.12963688
29	Adipocytokine signaling pathway_Homo sapiens_hsa04920	1.12580030
30	Endocytosis_Homo sapiens_hsa04144	1.04948285
31	Phototransduction_Homo sapiens_hsa04744	1.04103838
32	Glycolysis / Gluconeogenesis_Homo sapiens_hsa00010	0.98727825
33	Protein digestion and absorption_Homo sapiens_hsa04974	0.97832510
34	Influenza A_Homo sapiens_hsa05164	0.91721640
35	Inositol phosphate metabolism_Homo sapiens_hsa00562	0.89885844
36	Mucin type O-Glycan biosynthesis_Homo sapiens_hsa00512	0.89417230
37	Thyroid hormone signaling pathway_Homo sapiens_hsa04919	0.86470091
38	Fanconi anemia pathway_Homo sapiens_hsa03460	0.83433395
39	Calcium signaling pathway_Homo sapiens_hsa04020	0.82705590
40	Salivary secretion_Homo sapiens_hsa04970	0.80511636
41	Neuroactive ligand-receptor interaction_Homo sapiens_hsa04080	0.80252404
42	VEGF signaling pathway_Homo sapiens_hsa04370	0.75953326
43	cAMP signaling pathway_Homo sapiens_hsa04024	0.75865700
44	Acute myeloid leukemia_Homo sapiens_hsa05221	0.75189172
45	ABC transporters_Homo sapiens_hsa02010	0.74471979
46	Estrogen signaling pathway_Homo sapiens_hsa04915	0.73773892
47	Ubiquitin mediated proteolysis_Homo sapiens_hsa04120	0.72652301
48	Selenocompound metabolism_Homo sapiens_hsa00450	0.70069884
49	Cardiac muscle contraction_Homo sapiens_hsa04260	0.69386595
50	Morphine addiction_Homo sapiens_hsa05032	0.67760463
51	Phosphatidylinositol signaling system_Homo sapiens_hsa04070	0.64987875
52	MAPK signaling pathway_Homo sapiens_hsa04010	0.63374713
53	Arginine biosynthesis_Homo sapiens_hsa00220	0.63283635
54	Purine metabolism_Homo sapiens_hsa00230	0.62934291
55	Renin-angiotensin system_Homo sapiens_hsa04614	0.59857766
56	Valine, leucine and isoleucine degradation_Homo sapiens_hsa00280	0.59470057
57	Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa04960	0.58955245
58	Cell cycle_Homo sapiens_hsa04110	0.57863479
59	Aldosterone synthesis and secretion_Homo sapiens_hsa04925	0.56404064
60	Nicotine addiction_Homo sapiens_hsa05033	0.56102451
61	Viral carcinogenesis_Homo sapiens_hsa05203	0.52560293
62	Hedgehog signaling pathway_Homo sapiens_hsa04340	0.52216848
63	Tyrosine metabolism_Homo sapiens_hsa00350	0.52214417
64	Retinol metabolism_Homo sapiens_hsa00830	0.51949469
65	Fat digestion and absorption_Homo sapiens_hsa04975	0.51249342
66	Maturity onset diabetes of the young_Homo sapiens_hsa04950	0.49865646
67	PPAR signaling pathway_Homo sapiens_hsa03320	0.44895314
68	Circadian entrainment_Homo sapiens_hsa04713	0.44695878
69	Synaptic vesicle cycle_Homo sapiens_hsa04721	0.44201554
70	Base excision repair_Homo sapiens_hsa03410	0.43268988
71	Jak-STAT signaling pathway_Homo sapiens_hsa04630	0.42706332
72	Herpes simplex infection_Homo sapiens_hsa05168	0.41964619
73	Glutamatergic synapse_Homo sapiens_hsa04724	0.39256673
74	mTOR signaling pathway_Homo sapiens_hsa04150	0.37632328
75	Vascular smooth muscle contraction_Homo sapiens_hsa04270	0.37076173
76	Prostate cancer_Homo sapiens_hsa05215	0.36092984
77	Prolactin signaling pathway_Homo sapiens_hsa04917	0.35007813
78	Carbohydrate digestion and absorption_Homo sapiens_hsa04973	0.34372343
79	ErbB signaling pathway_Homo sapiens_hsa04012	0.34167900
80	Insulin secretion_Homo sapiens_hsa04911	0.33832502
81	Fc gamma R-mediated phagocytosis_Homo sapiens_hsa04666	0.32914683
82	Cholinergic synapse_Homo sapiens_hsa04725	0.32537765
83	Lysine degradation_Homo sapiens_hsa00310	0.29434733
84	Homologous recombination_Homo sapiens_hsa03440	0.29276807
85	Glycerolipid metabolism_Homo sapiens_hsa00561	0.28970926
86	Ribosome biogenesis in eukaryotes_Homo sapiens_hsa03008	0.28280692
87	Choline metabolism in cancer_Homo sapiens_hsa05231	0.27931505
88	cGMP-PKG signaling pathway_Homo sapiens_hsa04022	0.27888574
89	Linoleic acid metabolism_Homo sapiens_hsa00591	0.27861170
90	B cell receptor signaling pathway_Homo sapiens_hsa04662	0.26794247
91	Epstein-Barr virus infection_Homo sapiens_hsa05169	0.25725723
92	Bile secretion_Homo sapiens_hsa04976	0.25173815
93	Renin secretion_Homo sapiens_hsa04924	0.24475239
94	Gastric acid secretion_Homo sapiens_hsa04971	0.23952270
95	Serotonergic synapse_Homo sapiens_hsa04726	0.23440135
96	Nucleotide excision repair_Homo sapiens_hsa03420	0.22748339
97	Retrograde endocannabinoid signaling_Homo sapiens_hsa04723	0.22426751
98	Non-small cell lung cancer_Homo sapiens_hsa05223	0.21710407
99	Transcriptional misregulation in cancer_Homo sapiens_hsa05202	0.20767266
100	Pancreatic secretion_Homo sapiens_hsa04972	0.19976422

HOMER2P1

Functional Annotation Prediction

Predicted biological processes (GO)

Predicted upstream transcription factors (ChEA)

Predicted mouse phenotypes (MGI)

Predicted human phenotypes

Predicted kinase interactions (KEA)

Predicted pathways (KEGG)

Most similar genes based on co-expression Upload to Enrichr

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