HOMER2P2

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: No gene information available for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1sperm capacitation (GO:0048240)9.71519948
2response to pheromone (GO:0019236)9.42405195
3chromosome condensation (GO:0030261)9.30133216
4DNA packaging (GO:0006323)8.99116093
5plasma membrane fusion (GO:0045026)8.96298655
6microtubule depolymerization (GO:0007019)8.68941465
7spermatid development (GO:0007286)8.43919330
8sexual reproduction (GO:0019953)8.17549219
9spermatid nucleus differentiation (GO:0007289)8.12919592
10single strand break repair (GO:0000012)8.06540740
11sperm-egg recognition (GO:0035036)7.79043210
12reproduction (GO:0000003)7.32359779
13multicellular organism reproduction (GO:0032504)7.30860562
14negative regulation of inclusion body assembly (GO:0090084)7.18396785
15binding of sperm to zona pellucida (GO:0007339)7.15838413
16calcium ion-dependent exocytosis (GO:0017156)6.75496867
17microtubule polymerization or depolymerization (GO:0031109)6.74240455
18rRNA methylation (GO:0031167)6.71950927
19phosphatidylethanolamine biosynthetic process (GO:0006646)6.50054125
20protein polyglutamylation (GO:0018095)6.42261278
21cell-cell recognition (GO:0009988)6.40890589
22cellular ketone body metabolic process (GO:0046950)6.10454173
23spermatogenesis (GO:0007283)6.03003711
24male gamete generation (GO:0048232)6.00818153
25phosphatidylethanolamine metabolic process (GO:0046337)5.97560403
26rRNA modification (GO:0000154)5.93079496
27axonemal dynein complex assembly (GO:0070286)5.89376301
28microtubule severing (GO:0051013)5.85726273
29protein targeting to Golgi (GO:0000042)5.69756063
30gamete generation (GO:0007276)5.51057215
31establishment of protein localization to Golgi (GO:0072600)5.47037397
32ketone body metabolic process (GO:1902224)5.39171050
33retrograde transport, vesicle recycling within Golgi (GO:0000301)5.28257739
34regulation of Rab GTPase activity (GO:0032313)5.24207535
35positive regulation of Rab GTPase activity (GO:0032851)5.24207535
36antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-independent (G5.18292124
37regulation of inclusion body assembly (GO:0090083)5.10391383
38centriole replication (GO:0007099)5.05671595
39regulation of cilium movement (GO:0003352)4.98491346
40single fertilization (GO:0007338)4.95727778
41regulation of transcription involved in cell fate commitment (GO:0060850)4.89180093
42cell wall macromolecule catabolic process (GO:0016998)4.67273147
43germ cell development (GO:0007281)4.66703382
44motile cilium assembly (GO:0044458)4.57957201
45centriole assembly (GO:0098534)4.52881790
46cellular process involved in reproduction in multicellular organism (GO:0022412)4.43613408
47chromatin silencing (GO:0006342)4.43425882
48multicellular organismal reproductive process (GO:0048609)4.41640621
49cell wall macromolecule metabolic process (GO:0044036)4.38968476
50cilium or flagellum-dependent cell motility (GO:0001539)4.30137109
51RNA destabilization (GO:0050779)4.29095654
52seminiferous tubule development (GO:0072520)4.24720634
53protein localization to Golgi apparatus (GO:0034067)4.09799027
54coenzyme catabolic process (GO:0009109)4.03556717
55nucleus organization (GO:0006997)4.03253490
56fertilization (GO:0009566)4.01655523
57organic cation transport (GO:0015695)3.80081132
58regulation of centriole replication (GO:0046599)3.74836990
59response to acidic pH (GO:0010447)3.74020663
60peptidyl-threonine dephosphorylation (GO:0035970)3.69588530
61negative regulation of Rho protein signal transduction (GO:0035024)3.66893457
62regulation of microtubule-based movement (GO:0060632)3.63624832
63musculoskeletal movement (GO:0050881)3.63340575
64multicellular organismal movement (GO:0050879)3.63340575
65epithelial cilium movement (GO:0003351)3.57081684
66glycerol ether metabolic process (GO:0006662)3.51972128
67cellular response to pH (GO:0071467)3.50142791
68polyamine biosynthetic process (GO:0006596)3.49863113
69regulation of somitogenesis (GO:0014807)3.39876210
70membrane protein intracellular domain proteolysis (GO:0031293)3.36403656
71nucleosome disassembly (GO:0006337)3.36385414
72protein-DNA complex disassembly (GO:0032986)3.36385414
73cartilage development involved in endochondral bone morphogenesis (GO:0060351)3.33728741
74cerebral cortex neuron differentiation (GO:0021895)3.26986108
75ether metabolic process (GO:0018904)3.24527171
76homeostasis of number of cells within a tissue (GO:0048873)3.24374952
77protein depolymerization (GO:0051261)3.23248358
78regulation of interleukin-13 production (GO:0032656)3.20872607
79cilium movement (GO:0003341)3.20657671
80cell differentiation involved in metanephros development (GO:0072202)3.13106452
81mesenchymal cell differentiation involved in kidney development (GO:0072161)3.13079440
82mesenchymal cell differentiation involved in renal system development (GO:2001012)3.13079440
83regulation of T-helper 2 cell differentiation (GO:0045628)3.10767271
84negative regulation of gene expression, epigenetic (GO:0045814)3.10019426
85multicellular organismal development (GO:0007275)3.06651947
86cranial nerve morphogenesis (GO:0021602)3.06121583
87histone H3-K9 demethylation (GO:0033169)3.00981908
88cell recognition (GO:0008037)2.99814944
89NAD biosynthetic process (GO:0009435)2.99314252
90DNA conformation change (GO:0071103)2.92229558
91negative regulation of mesenchymal cell apoptotic process (GO:2001054)2.89324216
92regulation of phosphoprotein phosphatase activity (GO:0043666)2.81256056
93mast cell activation involved in immune response (GO:0002279)2.77818685
94mast cell degranulation (GO:0043303)2.77818685
95tooth mineralization (GO:0034505)2.76684307
96mitotic G1 DNA damage checkpoint (GO:0031571)2.76536252
97actin filament capping (GO:0051693)2.71557176
98acrosome reaction (GO:0007340)12.4917254
99fusion of sperm to egg plasma membrane (GO:0007342)11.8253292
100sperm motility (GO:0030317)11.7098571

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat5.41648042
2MYCN_19997598_ChIP-ChIP_NEUROBLASTOMA_Human3.91557398
3SOX9_22984422_ChIP-ChIP_TESTIS_Rat3.43454142
4TEAD4_26923725_Chip-Seq_HEMANGIOBLAST_Mouse2.43063719
5POU5F1_26923725_Chip-Seq_MESODERM_Mouse2.43063719
6ELF1_20517297_ChIP-Seq_JURKAT_Human2.41549221
7VDR_20736230_ChIP-Seq_LYMPHOBLASTOID_Human2.35489404
8STAT6_21828071_ChIP-Seq_BEAS2B_Human2.20443715
9IRF4_20064451_ChIP-Seq_CD4+T_Mouse2.04085827
10CBP_20019798_ChIP-Seq_JUKART_Human2.04085827
11RBPJ_21746931_ChIP-Seq_IB4-LCL_Human2.00745017
12CTBP2_25329375_ChIP-Seq_LNCAP_Human2.00676029
13CTCF_27219007_Chip-Seq_Bcells_Human1.97745623
14BCL6_27268052_Chip-Seq_Bcells_Human1.97532437
15ERA_21632823_ChIP-Seq_H3396_Human1.97252505
16EBNA2_21746931_ChIP-Seq_IB4-LCL_Human1.96941897
17EZH2_22144423_ChIP-Seq_EOC_Human1.94794634
18CTBP1_25329375_ChIP-Seq_LNCAP_Human1.93849079
19RAC3_21632823_ChIP-Seq_H3396_Human1.93088593
20NANOG_20526341_ChIP-Seq_ESCs_Human1.92439657
21EBNA1_20929547_Chip-Seq_RAJI-cells_Human1.90995792
22MYCN_21190229_ChIP-Seq_SHEP-21N_Human1.89788690
23DROSHA_22980978_ChIP-Seq_HELA_Human1.86452003
24E2F1_20622854_ChIP-Seq_HELA_Human1.84982556
25BCOR_27268052_Chip-Seq_Bcells_Human1.78997772
26TDRD3_21172665_ChIP-Seq_MCF-7_Human1.78025036
27WDR5_24793694_ChIP-Seq_LNCAP_Human1.77486801
28EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human1.76985698
29SMC4_20622854_ChIP-Seq_HELA_Human1.71938187
30YY1_22570637_ChIP-Seq_MALME-3M_Human1.70409797
31TAF2_19829295_ChIP-Seq_ESCs_Human1.70131727
32PHF8_20622854_ChIP-Seq_HELA_Human1.68864106
33P68_20966046_ChIP-Seq_HELA_Human1.65994409
34CTCF_20526341_ChIP-Seq_ESCs_Human1.64111298
35LXR_22292898_ChIP-Seq_THP-1_Human1.60552565
36P300_27268052_Chip-Seq_Bcells_Human1.57908866
37MYC_19829295_ChIP-Seq_ESCs_Human1.57453612
38FUS_26573619_Chip-Seq_HEK293_Human1.55167162
39PPARD_23208498_ChIP-Seq_MDA-MB-231_Human1.54869005
40TP63_22573176_ChIP-Seq_HFKS_Human1.52941851
41TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.51570197
42AUTS2_25519132_ChIP-Seq_293T-REX_Human1.49813608
43OCT4_20526341_ChIP-Seq_ESCs_Human1.49520283
44UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human1.48734981
45SMAD2/3_21741376_ChIP-Seq_ESCs_Human1.46867939
46BP1_19119308_ChIP-ChIP_Hs578T_Human1.46224824
47SMAD4_21741376_ChIP-Seq_EPCs_Human1.44247252
48TP63_19390658_ChIP-ChIP_HaCaT_Human1.38618945
49P63_20808887_ChIP-Seq_KERATINOCYTES_Human1.36908794
50ETV2_25802403_ChIP-Seq_MESCs_Mouse1.36850851
51RUNX_20019798_ChIP-Seq_JUKART_Human1.36784015
52SCL_21571218_ChIP-Seq_MEGAKARYOCYTES_Human1.35707275
53ARNT_22903824_ChIP-Seq_MCF-7_Human1.33989079
54ERG_20517297_ChIP-Seq_VCAP_Human1.33608966
55KLF1_20508144_ChIP-Seq_FETAL-LIVER-ERYTHROID_Mouse1.33444103
56SOX2_22085726_ChIP-Seq_NPCs_Mouse1.32594733
57SUZ12_27294783_Chip-Seq_ESCs_Mouse1.32279841
58TP53_18474530_ChIP-ChIP_U2OS_Human1.31068627
59HNFA_21074721_ChIP-Seq_CACO-2_Human1.29833181
60SMAD3_21741376_ChIP-Seq_ESCs_Human1.29288851
61AR_25329375_ChIP-Seq_VCAP_Human1.28975542
62SMAD2/3_21741376_ChIP-Seq_EPCs_Human1.28165709
63ER_23166858_ChIP-Seq_MCF-7_Human1.27640365
64EWS-FLI1_20517297_ChIP-Seq_SK-N-MC_Human1.26683208
65P53_21459846_ChIP-Seq_SAOS-2_Human1.24514316
66GATA3_21878914_ChIP-Seq_MCF-7_Human1.24483575
67CEBPB_22108803_ChIP-Seq_LS180_Human1.24447851
68RBPJ_21746931_ChIP-Seq_IB4_Human1.24022103
69TAF15_26573619_Chip-Seq_HEK293_Human1.23397449
70CDX2_21074721_ChIP-Seq_CACO-2_Mouse1.22700426
71SA1_27219007_Chip-Seq_Bcells_Human1.21880974
72CBX2_22325352_ChIP-Seq_293T-Rex_Human1.21120997
73ETV1_20927104_ChIP-Seq_GIST48_Human1.17653569
74PBX1_22567123_ChIP-ChIP_OVCAR3_Human1.15974576
75SMRT_27268052_Chip-Seq_Bcells_Human1.15608957
76DMRT1_21621532_ChIP-ChIP_FETAL_Ovary1.14594014
77THRA_23701648_ChIP-Seq_CEREBELLUM_Mouse1.12786390
78RUNX1_26923725_Chip-Seq_HPCs_Mouse1.12324313
79EZH2_27294783_Chip-Seq_ESCs_Mouse1.12249898
80ERA_27197147_Chip-Seq_ENDOMETRIOID-ADENOCARCINOMA_Human1.10800741
81SMAD3_21741376_ChIP-Seq_EPCs_Human1.10152165
82CSB_26484114_Chip-Seq_FIBROBLAST_Human1.09160290
83KLF5_20875108_ChIP-Seq_MESCs_Mouse1.08829916
84SA1_27219007_Chip-Seq_ERYTHROID_Human1.08513754
85NR4A2_19515692_ChIP-ChIP_MN9D_Mouse1.06912514
86NFYB_21822215_ChIP-Seq_K562_Human1.06904233
87SMAD4_21741376_ChIP-Seq_HESCs_Human1.06550048
88CHD7_19251738_ChIP-ChIP_MESCs_Mouse1.04140993
89TOP2B_26459242_ChIP-Seq_MCF-7_Human1.02790022
90VDR_24787735_ChIP-Seq_THP-1_Human1.00836484
91GATA6_21074721_ChIP-Seq_CACO-2_Human1.00143753
92SPI1_20517297_ChIP-Seq_HL60_Human0.99456148
93OCT1_27270436_Chip-Seq_PROSTATE_Human0.98488709
94NANOG_19829295_ChIP-Seq_ESCs_Human0.97648759
95SOX2_19829295_ChIP-Seq_ESCs_Human0.97648759
96PHF8_20622853_ChIP-Seq_HELA_Human0.96877578
97OCT4_19829295_ChIP-Seq_ESCs_Human0.96828963
98TBL1_22424771_ChIP-Seq_293T_Human0.96800762
99HOXB7_26014856_ChIP-Seq_BT474_Human0.96336957
100SOX11_22085726_ChIP-Seq_ESNs_Mouse0.96260031

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0005670_abnormal_white_adipose4.76111950
2MP0003878_abnormal_ear_physiology4.74949867
3MP0005377_hearing/vestibular/ear_phenot4.74949867
4MP0003698_abnormal_male_reproductive4.47153637
5MP0001929_abnormal_gametogenesis3.84217590
6MP0001348_abnormal_lacrimal_gland3.06988406
7MP0000678_abnormal_parathyroid_gland2.62918493
8MP0003011_delayed_dark_adaptation2.60056638
9MP0002161_abnormal_fertility/fecundity2.53101298
10MP0003718_maternal_effect2.17743967
11MP0002132_abnormal_respiratory_system2.13973048
12MP0005410_abnormal_fertilization12.5352971
13MP0002234_abnormal_pharynx_morphology1.88185513
14MP0003646_muscle_fatigue1.81065164
15MP0005423_abnormal_somatic_nervous1.72835839
16MP0002210_abnormal_sex_determination1.63152453
17MP0002249_abnormal_larynx_morphology1.60709351
18MP0002822_catalepsy1.49039263
19MP0004510_myositis1.48670826
20MP0009053_abnormal_anal_canal1.45727945
21MP0005379_endocrine/exocrine_gland_phen1.45274284
22MP0005083_abnormal_biliary_tract1.44495738
23MP0005310_abnormal_salivary_gland1.37770890
24MP0002282_abnormal_trachea_morphology1.37652386
25MP0001145_abnormal_male_reproductive1.36172894
26MP0001485_abnormal_pinna_reflex1.33943033
27MP0000653_abnormal_sex_gland1.30087549
28MP0001765_abnormal_ion_homeostasis1.26580343
29MP0001486_abnormal_startle_reflex1.22861134
30MP0009697_abnormal_copulation1.21391768
31MP0004859_abnormal_synaptic_plasticity1.16104199
32MP0001968_abnormal_touch/_nociception1.13454464
33MP0002735_abnormal_chemical_nociception1.13420909
34MP0002653_abnormal_ependyma_morphology1.12778919
35MP0002127_abnormal_cardiovascular_syste1.12542851
36MP0000534_abnormal_ureter_morphology1.11858016
37MP0002138_abnormal_hepatobiliary_system1.10497843
38MP0004742_abnormal_vestibular_system1.10334177
39MP0001963_abnormal_hearing_physiology0.99318668
40MP0005451_abnormal_body_composition0.96540327
41MP0005395_other_phenotype0.92829654
42MP0000681_abnormal_thyroid_gland0.92546341
43MP0005367_renal/urinary_system_phenotyp0.92406224
44MP0000516_abnormal_urinary_system0.92406224
45MP0000026_abnormal_inner_ear0.92342362
46MP0008569_lethality_at_weaning0.91538821
47MP0002229_neurodegeneration0.84164868
48MP0008877_abnormal_DNA_methylation0.82568099
49MP0005084_abnormal_gallbladder_morpholo0.82372770
50MP0003879_abnormal_hair_cell0.81157599
51MP0000955_abnormal_spinal_cord0.80853097
52MP0000049_abnormal_middle_ear0.79876254
53MP0001905_abnormal_dopamine_level0.78990414
54MP0005248_abnormal_Harderian_gland0.77959581
55MP0005636_abnormal_mineral_homeostasis0.77109311
56MP0000003_abnormal_adipose_tissue0.76639879
57MP0005375_adipose_tissue_phenotype0.74385467
58MP0009115_abnormal_fat_cell0.73132116
59MP0004085_abnormal_heartbeat0.72869355
60MP0002067_abnormal_sensory_capabilities0.71649701
61MP0005666_abnormal_adipose_tissue0.71598689
62MP0001666_abnormal_nutrient_absorption0.70045238
63MP0005551_abnormal_eye_electrophysiolog0.69453663
64MP0001879_abnormal_lymphatic_vessel0.66978123
65MP0002733_abnormal_thermal_nociception0.66369548
66MP0004484_altered_response_of0.65646042
67MP0008961_abnormal_basal_metabolism0.62893407
68MP0000613_abnormal_salivary_gland0.59713958
69MP0004233_abnormal_muscle_weight0.59513249
70MP0005253_abnormal_eye_physiology0.58768773
71MP0002557_abnormal_social/conspecific_i0.57233260
72MP0001984_abnormal_olfaction0.56079402
73MP0008789_abnormal_olfactory_epithelium0.52550334
74MP0003137_abnormal_impulse_conducting0.50697665
75MP0002572_abnormal_emotion/affect_behav0.49769881
76MP0006292_abnormal_olfactory_placode0.48611203
77MP0002272_abnormal_nervous_system0.47513400
78MP0003699_abnormal_female_reproductive0.47381834
79MP0003077_abnormal_cell_cycle0.46227235
80MP0000249_abnormal_blood_vessel0.45876181
81MP0003880_abnormal_central_pattern0.44799409
82MP0001970_abnormal_pain_threshold0.44199590
83MP0009764_decreased_sensitivity_to0.43822610
84MP0005167_abnormal_blood-brain_barrier0.41439811
85MP0000470_abnormal_stomach_morphology0.40893790
86MP0005166_decreased_susceptibility_to0.40625987
87MP0005535_abnormal_body_temperature0.39812572
88MP0002734_abnormal_mechanical_nocicepti0.39692583
89MP0001440_abnormal_grooming_behavior0.39615516
90MP0008995_early_reproductive_senescence0.38638762
91MP0009745_abnormal_behavioral_response0.36661007
92MP0000230_abnormal_systemic_arterial0.35645646
93MP0002928_abnormal_bile_duct0.35159263
94MP0005394_taste/olfaction_phenotype0.34124931
95MP0005499_abnormal_olfactory_system0.34124931
96MP0003936_abnormal_reproductive_system0.33894974
97MP0003119_abnormal_digestive_system0.33499635
98MP0005647_abnormal_sex_gland0.33312134
99MP0001545_abnormal_hematopoietic_system0.30860026
100MP0005397_hematopoietic_system_phenotyp0.30860026

Predicted human phenotypes

RankGene SetZ-score
1Severe visual impairment (HP:0001141)8.68301836
2Attenuation of retinal blood vessels (HP:0007843)5.51573091
3Bony spicule pigmentary retinopathy (HP:0007737)5.48968044
4Dynein arm defect of respiratory motile cilia (HP:0012255)5.34054510
5Absent/shortened dynein arms (HP:0200106)5.34054510
6Asymmetric septal hypertrophy (HP:0001670)4.99042609
7Bell-shaped thorax (HP:0001591)4.92241126
8Abnormal rod and cone electroretinograms (HP:0008323)4.82553364
9Resting tremor (HP:0002322)4.58764150
10Hypoplastic ischia (HP:0003175)4.49776008
11Tubulointerstitial nephritis (HP:0001970)4.46828339
12Enlarged epiphyses (HP:0010580)4.35410925
13Parkinsonism with favorable response to dopaminergic medication (HP:0002548)4.31236460
14Abnormal ciliary motility (HP:0012262)4.21874248
15Hyperkalemia (HP:0002153)4.21707549
16Abnormal respiratory motile cilium physiology (HP:0012261)4.11297927
17Infertility (HP:0000789)4.07508858
18Facial shape deformation (HP:0011334)4.02156499
19Potter facies (HP:0002009)4.02156499
20Abnormality of the ischium (HP:0003174)3.97130415
21Chronic hepatic failure (HP:0100626)3.96278203
22Male infertility (HP:0003251)3.96274915
23Abnormal respiratory motile cilium morphology (HP:0005938)3.94049748
24Abnormal respiratory epithelium morphology (HP:0012253)3.94049748
25Abnormality of macular pigmentation (HP:0008002)3.90042219
26Hypoplasia of the thymus (HP:0000778)3.80927050
27Nasal polyposis (HP:0100582)3.76762735
28Azoospermia (HP:0000027)3.68656889
29Abnormal spermatogenesis (HP:0008669)3.59655407
30Aplasia/Hypoplasia of the pubic bone (HP:0009104)3.57941132
31Respiratory insufficiency due to defective ciliary clearance (HP:0200073)3.44439715
32Generalized aminoaciduria (HP:0002909)3.44167824
33Aplasia/Hypoplasia of the earlobes (HP:0009906)3.42679536
34Unilateral renal agenesis (HP:0000122)3.35937175
35Impulsivity (HP:0100710)3.29141680
36Cone-rod dystrophy (HP:0000548)3.21681006
37Abnormality of the nasal mucosa (HP:0000433)3.02570253
38Double outlet right ventricle (HP:0001719)3.00238491
39Congenital malformation of the right heart (HP:0011723)3.00238491
40Postural instability (HP:0002172)2.99212695
41Menstrual irregularities (HP:0000858)2.75194267
42Abnormality of the parathyroid morphology (HP:0011766)2.71458441
43Abnormality of potassium homeostasis (HP:0011042)2.69271695
44Epiphyseal dysplasia (HP:0002656)2.68382061
45Abnormal urine output (HP:0012590)2.67549751
46Abnormality of the aortic arch (HP:0012303)2.65427965
47Progressive sensorineural hearing impairment (HP:0000408)2.64789489
48Renal dysplasia (HP:0000110)2.62148879
49Nephronophthisis (HP:0000090)2.58004198
50Absent epiphyses (HP:0010577)2.55058976
51Aplasia/Hypoplasia of the capital femoral epiphysis (HP:0005003)2.55058976
52Abnormality of the costochondral junction (HP:0000919)2.52553048
53Rhinitis (HP:0012384)2.45642467
54Hypoalphalipoproteinemia (HP:0003233)2.44515614
55Recurrent pneumonia (HP:0006532)2.43579793
56Failure to thrive in infancy (HP:0001531)2.38141870
57Portal hypertension (HP:0001409)2.37076804
58Truncal obesity (HP:0001956)2.34819350
59Amelogenesis imperfecta (HP:0000705)2.32697469
60Stage 5 chronic kidney disease (HP:0003774)2.32315218
61Abnormality of renal excretion (HP:0011036)2.28754111
62Insulin-resistant diabetes mellitus (HP:0000831)2.24820569
63Flattened epiphyses (HP:0003071)2.23558928
64Renovascular hypertension (HP:0100817)2.22042769
65Abnormality of the pubic bones (HP:0003172)2.17891829
66Abnormality of the epiphysis of the femoral head (HP:0010574)2.17196700
67Abnormality of the hepatic vasculature (HP:0006707)2.16044233
68Ventricular tachycardia (HP:0004756)2.15438104
69Widely patent fontanelles and sutures (HP:0004492)2.14633515
70Abnormality of the renal medulla (HP:0100957)2.12939920
71Tetany (HP:0001281)2.12898592
72Muscle fiber atrophy (HP:0100295)2.11849532
73Abnormal drinking behavior (HP:0030082)2.09870305
74Polydipsia (HP:0001959)2.09870305
75Progressive cerebellar ataxia (HP:0002073)2.07237513
76Hyperthyroidism (HP:0000836)2.03933224
77Polyuria (HP:0000103)2.03842021
78Abnormality of femoral epiphyses (HP:0006499)2.03115505
79Abnormality involving the epiphyses of the lower limbs (HP:0006500)2.03115505
80Aplasia/Hypoplasia of the thymus (HP:0010515)2.02915757
81Tubulointerstitial abnormality (HP:0001969)2.01308891
82Vertebral clefting (HP:0008428)2.00363555
83Aplasia/Hypoplasia of the sacrum (HP:0008517)2.00028665
84Abnormality of dental color (HP:0011073)1.99496275
85Abnormal ventriculo-arterial connection (HP:0011563)1.94422541
86Transposition of the great arteries (HP:0001669)1.94422541
87Abnormal connection of the cardiac segments (HP:0011545)1.94422541
88Abnormality of the femoral head (HP:0003368)1.92832867
89Hyponatremia (HP:0002902)1.92726304
90Osteomalacia (HP:0002749)1.92254110
91Decreased central vision (HP:0007663)1.91289098
92Hypokalemia (HP:0002900)1.88162660
93Flat capital femoral epiphysis (HP:0003370)1.87939464
94Renal Fanconi syndrome (HP:0001994)1.85610103
95Atelectasis (HP:0100750)1.84330047
96Short ribs (HP:0000773)1.84117257
97Mixed hearing impairment (HP:0000410)1.84023368
98Peripheral hypomyelination (HP:0007182)1.83857091
99Hypoparathyroidism (HP:0000829)1.83618462
100Bronchiectasis (HP:0002110)1.82704007

Predicted kinase interactions (KEA)

RankGene SetZ-score
1PLK47.54716158
2TESK16.87674162
3DDR25.84820922
4MAP4K23.73900052
5INSRR3.70336477
6STK383.23729346
7PLK22.60899550
8MAPK152.57056288
9PNCK2.54463210
10STK38L2.24011783
11BRD42.21580687
12PRKD32.20936190
13CAMK1G1.98689057
14MST1R1.81748254
15NME21.64422488
16WNK11.60240740
17PDPK11.54079813
18DYRK1B1.48964671
19PIK3CG1.40196366
20KIT1.39648115
21CDK71.37495172
22PDK11.35279878
23VRK21.33146669
24PTK2B1.03769429
25KSR21.02857375
26CDK121.01503004
27TESK20.96398765
28NEK60.95626616
29MAP3K110.92211311
30UHMK10.86464447
31MAP3K90.76740261
32AKT30.75987332
33MAP3K20.73950794
34RPS6KA10.71319981
35RPS6KA20.69968330
36BCKDK0.69683060
37RIPK40.68915719
38WNK40.66180729
39CAMK1D0.65596809
40BLK0.64120175
41PRKG20.58721443
42PRKG10.58603822
43STK390.58377074
44ROCK10.57667835
45MAP3K80.55626570
46BRAF0.53978628
47MAP2K20.52053683
48CDK20.50276014
49CDK40.49699333
50LATS20.49651470
51PRKAA20.47659879
52MUSK0.45938608
53CAMK10.45470723
54GSK3B0.45132451
55VRK10.44996495
56RPS6KL10.41951217
57RPS6KC10.41951217
58RPS6KA60.39688930
59MAPK10.39137604
60CDK30.38642577
61SIK20.38071977
62CDK10.36760171
63BMPR1B0.35972469
64MAP3K10.35970889
65ABL20.35743016
66PRKCZ0.35452401
67PRKCG0.32567733
68MAPK80.32521344
69MTOR0.31025707
70TLK10.28737247
71SGK4940.27055004
72SGK2230.27055004
73CHEK10.26876416
74CAMK40.26244078
75JAK30.25398778
76PINK10.24876237
77RIPK10.24333683
78NTRK30.23490087
79GRK60.23316726
80PRKCB0.22915268
81CHUK0.22492671
82LATS10.21776033
83MAPK110.21671638
84MAPK140.21579965
85IKBKB0.21116302
86KDR0.19428366
87SYK0.19051220
88SGK10.17652814
89MAPK100.17157405
90ARAF0.15508597
91MARK10.15505308
92TYRO30.15373932
93AKT10.14663927
94FLT30.13391441
95MET0.12331347
96MARK20.10966705
97PRKACA0.10796675
98PRKCQ0.09529136
99MINK10.09204571
100TIE10.08225163

Predicted pathways (KEGG)

RankGene SetZ-score
1Synthesis and degradation of ketone bodies_Homo sapiens_hsa000728.61531022
2Fatty acid biosynthesis_Homo sapiens_hsa000616.44066611
3Olfactory transduction_Homo sapiens_hsa047403.33597369
4Butanoate metabolism_Homo sapiens_hsa006502.68284072
5Allograft rejection_Homo sapiens_hsa053302.19516724
6Autoimmune thyroid disease_Homo sapiens_hsa053202.12743956
7Type I diabetes mellitus_Homo sapiens_hsa049402.11649540
8Glycerophospholipid metabolism_Homo sapiens_hsa005642.01995780
9Graft-versus-host disease_Homo sapiens_hsa053322.01830442
10Antigen processing and presentation_Homo sapiens_hsa046121.99826688
11Phenylalanine metabolism_Homo sapiens_hsa003601.68121004
12Dorso-ventral axis formation_Homo sapiens_hsa043201.63372759
13Viral myocarditis_Homo sapiens_hsa054161.61844247
14Fatty acid degradation_Homo sapiens_hsa000711.53855378
15Taste transduction_Homo sapiens_hsa047421.52047024
16Type II diabetes mellitus_Homo sapiens_hsa049301.49732230
17Butirosin and neomycin biosynthesis_Homo sapiens_hsa005241.49265719
18Glycolysis / Gluconeogenesis_Homo sapiens_hsa000101.46527692
19Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007601.45882800
20Longevity regulating pathway - multiple species_Homo sapiens_hsa042131.40868725
21Fatty acid metabolism_Homo sapiens_hsa012121.38033855
22RNA transport_Homo sapiens_hsa030131.31133737
23Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa049611.30638580
24Adipocytokine signaling pathway_Homo sapiens_hsa049201.15465403
25Selenocompound metabolism_Homo sapiens_hsa004501.12968310
26Protein digestion and absorption_Homo sapiens_hsa049741.12815844
27Endocytosis_Homo sapiens_hsa041441.12301786
28Arginine and proline metabolism_Homo sapiens_hsa003301.06728405
29Protein processing in endoplasmic reticulum_Homo sapiens_hsa041411.05910457
30Renin-angiotensin system_Homo sapiens_hsa046140.98606778
31Salivary secretion_Homo sapiens_hsa049700.97579323
32Phototransduction_Homo sapiens_hsa047440.91564688
33Influenza A_Homo sapiens_hsa051640.83655403
34Neuroactive ligand-receptor interaction_Homo sapiens_hsa040800.83015728
35Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005120.80802749
36Tyrosine metabolism_Homo sapiens_hsa003500.80026163
37ABC transporters_Homo sapiens_hsa020100.79713319
38PPAR signaling pathway_Homo sapiens_hsa033200.76406064
39Calcium signaling pathway_Homo sapiens_hsa040200.75951100
40Oocyte meiosis_Homo sapiens_hsa041140.73714046
41Morphine addiction_Homo sapiens_hsa050320.72403382
42Purine metabolism_Homo sapiens_hsa002300.71766486
43Thyroid hormone signaling pathway_Homo sapiens_hsa049190.71734753
44Cardiac muscle contraction_Homo sapiens_hsa042600.71045368
45Valine, leucine and isoleucine degradation_Homo sapiens_hsa002800.70792067
46cAMP signaling pathway_Homo sapiens_hsa040240.68458741
47Progesterone-mediated oocyte maturation_Homo sapiens_hsa049140.66088882
48Fat digestion and absorption_Homo sapiens_hsa049750.64782962
49Maturity onset diabetes of the young_Homo sapiens_hsa049500.64572753
50Arginine biosynthesis_Homo sapiens_hsa002200.64257352
51Synaptic vesicle cycle_Homo sapiens_hsa047210.64039400
52Hedgehog signaling pathway_Homo sapiens_hsa043400.60183294
53Inositol phosphate metabolism_Homo sapiens_hsa005620.56905121
54Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa049600.55126098
55Retinol metabolism_Homo sapiens_hsa008300.54894502
56Glycerolipid metabolism_Homo sapiens_hsa005610.53890864
57Circadian entrainment_Homo sapiens_hsa047130.52416015
58Nicotine addiction_Homo sapiens_hsa050330.50948390
59mRNA surveillance pathway_Homo sapiens_hsa030150.48607164
60Fanconi anemia pathway_Homo sapiens_hsa034600.46969654
61Estrogen signaling pathway_Homo sapiens_hsa049150.44451865
62Carbohydrate digestion and absorption_Homo sapiens_hsa049730.41288746
63Acute myeloid leukemia_Homo sapiens_hsa052210.41216501
64Aldosterone synthesis and secretion_Homo sapiens_hsa049250.41196893
65VEGF signaling pathway_Homo sapiens_hsa043700.38759840
66Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049640.37199414
67Insulin secretion_Homo sapiens_hsa049110.37039679
68Gastric acid secretion_Homo sapiens_hsa049710.36895003
69Transcriptional misregulation in cancer_Homo sapiens_hsa052020.34725896
70Biosynthesis of amino acids_Homo sapiens_hsa012300.34637906
71Nitrogen metabolism_Homo sapiens_hsa009100.33844518
72Retrograde endocannabinoid signaling_Homo sapiens_hsa047230.33820523
73Phosphatidylinositol signaling system_Homo sapiens_hsa040700.33634899
74MAPK signaling pathway_Homo sapiens_hsa040100.32895732
75Cholinergic synapse_Homo sapiens_hsa047250.32264397
76Renin secretion_Homo sapiens_hsa049240.31802476
77Vascular smooth muscle contraction_Homo sapiens_hsa042700.31508358
78Tight junction_Homo sapiens_hsa045300.31243657
79Primary bile acid biosynthesis_Homo sapiens_hsa001200.30089892
80Herpes simplex infection_Homo sapiens_hsa051680.29512603
81Pancreatic secretion_Homo sapiens_hsa049720.28608807
82Jak-STAT signaling pathway_Homo sapiens_hsa046300.28414448
83Ubiquitin mediated proteolysis_Homo sapiens_hsa041200.27427379
84Huntingtons disease_Homo sapiens_hsa050160.26140290
85Glutamatergic synapse_Homo sapiens_hsa047240.26019537
86Bile secretion_Homo sapiens_hsa049760.25552970
87Viral carcinogenesis_Homo sapiens_hsa052030.24600946
88Basal transcription factors_Homo sapiens_hsa030220.23787444
89Intestinal immune network for IgA production_Homo sapiens_hsa046720.23103339
90Toxoplasmosis_Homo sapiens_hsa051450.23084690
91Epstein-Barr virus infection_Homo sapiens_hsa051690.23030252
92Serotonergic synapse_Homo sapiens_hsa047260.21323834
93Chemical carcinogenesis_Homo sapiens_hsa052040.18484265
94GABAergic synapse_Homo sapiens_hsa047270.18215150
95Metabolic pathways_Homo sapiens_hsa011000.17699741
96Primary immunodeficiency_Homo sapiens_hsa053400.17534571
97Cell adhesion molecules (CAMs)_Homo sapiens_hsa045140.17431036
98B cell receptor signaling pathway_Homo sapiens_hsa046620.15366108
99Oxytocin signaling pathway_Homo sapiens_hsa049210.14814910
100Prolactin signaling pathway_Homo sapiens_hsa049170.13656768

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