HOMER3

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: This gene encodes a member of the HOMER family of postsynaptic density scaffolding proteins that share a similar domain structure consisting of an N-terminal Enabled/vasodilator-stimulated phosphoprotein homology 1 domain which mediates protein-protein interactions, and a carboxy-terminal coiled-coil domain and two leucine zipper motifs that are involved in self-oligomerization. The encoded protein binds numerous other proteins including group I metabotropic glutamate receptors, inositol 1,4,5-trisphosphate receptors and amyloid precursor proteins and has been implicated in diverse biological functions such as neuronal signaling, T-cell activation and trafficking of amyloid beta peptides. Alternative splicing results in multiple transcript variants. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1response to pheromone (GO:0019236)5.58434071
2cerebellar granule cell differentiation (GO:0021707)5.52859558
3protein localization to endosome (GO:0036010)4.84316925
4hemidesmosome assembly (GO:0031581)4.41075075
5negative regulation of endoplasmic reticulum calcium ion concentration (GO:0032471)4.39308635
6sodium ion export (GO:0071436)3.93857720
7mitotic G1 DNA damage checkpoint (GO:0031571)3.89702349
8amino sugar catabolic process (GO:0046348)3.89016429
9glial cell migration (GO:0008347)3.87206827
10positive regulation of synapse maturation (GO:0090129)3.81562115
11N-acetylneuraminate metabolic process (GO:0006054)3.70453739
12virion attachment to host cell (GO:0019062)3.54858489
13adhesion of symbiont to host cell (GO:0044650)3.54858489
14mannose metabolic process (GO:0006013)3.53812154
15cell differentiation in hindbrain (GO:0021533)3.50815590
16pinocytosis (GO:0006907)3.38971555
17skin morphogenesis (GO:0043589)3.36194684
18cerebellar Purkinje cell differentiation (GO:0021702)3.36174607
19semaphorin-plexin signaling pathway (GO:0071526)3.36088520
20hyaluronan catabolic process (GO:0030214)3.32336579
21vascular endothelial growth factor receptor signaling pathway (GO:0048010)3.26218562
22response to peptidoglycan (GO:0032494)3.25740784
23cell-substrate junction assembly (GO:0007044)3.24907128
24UV protection (GO:0009650)3.24328436
25mitotic G1/S transition checkpoint (GO:0044819)3.23430292
26protein retention in ER lumen (GO:0006621)3.23056049
27adhesion of symbiont to host (GO:0044406)3.19043958
28negative regulation of mRNA splicing, via spliceosome (GO:0048025)3.18377893
29locomotory exploration behavior (GO:0035641)3.16546002
30dichotomous subdivision of an epithelial terminal unit (GO:0060600)3.14997168
31outer ear morphogenesis (GO:0042473)3.11483854
32G1 DNA damage checkpoint (GO:0044783)3.11448645
33glycosphingolipid catabolic process (GO:0046479)3.11301108
34establishment of nucleus localization (GO:0040023)3.10709533
35modulation by symbiont of host cellular process (GO:0044068)3.07356099
36cellular potassium ion homeostasis (GO:0030007)3.06622387
37maintenance of protein localization in endoplasmic reticulum (GO:0035437)3.06576083
38venous blood vessel morphogenesis (GO:0048845)3.05660815
39cell adhesion mediated by integrin (GO:0033627)3.05655865
40establishment or maintenance of epithelial cell apical/basal polarity (GO:0045197)3.03659091
41adherens junction assembly (GO:0034333)3.00647180
42cytoskeletal anchoring at plasma membrane (GO:0007016)3.00116576
43plasma membrane repair (GO:0001778)2.99993252
44planar cell polarity pathway involved in neural tube closure (GO:0090179)2.99908531
45polarized epithelial cell differentiation (GO:0030859)2.96306658
46establishment of apical/basal cell polarity (GO:0035089)2.94527635
47peptidyl-lysine dimethylation (GO:0018027)2.94239835
48response to magnesium ion (GO:0032026)2.91812252
49paraxial mesoderm development (GO:0048339)2.91134050
50substrate-dependent cell migration (GO:0006929)2.90055857
51positive regulation of chemokine biosynthetic process (GO:0045080)2.88838783
52adenosine receptor signaling pathway (GO:0001973)2.85753620
53regulation of establishment of planar polarity involved in neural tube closure (GO:0090178)2.84211600
54heterochromatin organization (GO:0070828)2.82271216
55positive regulation of blood vessel endothelial cell migration (GO:0043536)2.80335738
56cell-cell junction maintenance (GO:0045217)2.78643247
57endoplasmic reticulum calcium ion homeostasis (GO:0032469)2.78580269
58negative regulation of catenin import into nucleus (GO:0035414)2.78285381
59regulation of atrial cardiac muscle cell membrane depolarization (GO:0060371)2.76579115
60positive regulation of membrane protein ectodomain proteolysis (GO:0051044)2.76180103
61axon extension involved in axon guidance (GO:0048846)2.74848173
62neuron projection extension involved in neuron projection guidance (GO:1902284)2.74848173
63positive regulation of histone deacetylation (GO:0031065)2.74719771
64activation of MAPKKK activity (GO:0000185)2.73707255
65cellular response to thyroid hormone stimulus (GO:0097067)2.71456696
66negative regulation of toll-like receptor 4 signaling pathway (GO:0034144)2.70606421
67protein heterotrimerization (GO:0070208)2.70454786
68negative regulation of microtubule polymerization (GO:0031115)2.69987181
69multicellular organismal movement (GO:0050879)2.69597395
70musculoskeletal movement (GO:0050881)2.69597395
71spinal cord development (GO:0021510)2.69213412
72positive regulation of syncytium formation by plasma membrane fusion (GO:0060143)2.68908109
73glycolipid catabolic process (GO:0019377)2.68083540
74negative regulation of cell size (GO:0045792)2.66810148
75glucocorticoid receptor signaling pathway (GO:0042921)2.66125952
76Golgi transport vesicle coating (GO:0048200)2.65754872
77COPI coating of Golgi vesicle (GO:0048205)2.65754872
78chondrocyte proliferation (GO:0035988)2.62946226
79positive regulation of macrophage cytokine production (GO:0060907)2.62279272
80basement membrane organization (GO:0071711)2.61147385
81collagen metabolic process (GO:0032963)2.60102653
82collagen catabolic process (GO:0030574)2.59836272
83pattern specification involved in kidney development (GO:0061004)2.58339226
84response to muramyl dipeptide (GO:0032495)2.57627773
85regulation of vascular endothelial growth factor signaling pathway (GO:1900746)2.56261057
86negative regulation of nitric oxide biosynthetic process (GO:0045019)2.55933715
87negative regulation of RNA splicing (GO:0033119)2.55624012
88regulation of tumor necrosis factor biosynthetic process (GO:0042534)2.54435795
89mesenchymal to epithelial transition involved in metanephros morphogenesis (GO:0003337)2.54408760
90gonadal mesoderm development (GO:0007506)2.54318433
91modulation by virus of host process (GO:0019054)2.53863505
92peptidyl-arginine omega-N-methylation (GO:0035247)2.52066867
93vascular endothelial growth factor signaling pathway (GO:0038084)2.50389337
94establishment or maintenance of bipolar cell polarity (GO:0061245)2.49960633
95establishment or maintenance of apical/basal cell polarity (GO:0035088)2.49960633
96negative regulation of nitric-oxide synthase activity (GO:0051001)2.49809768
97barbed-end actin filament capping (GO:0051016)2.49736036
98positive regulation of protein dephosphorylation (GO:0035307)2.49709087
99DNA unwinding involved in DNA replication (GO:0006268)2.49598710
100regulation of cellular response to vascular endothelial growth factor stimulus (GO:1902547)2.49407509
101positive regulation of receptor recycling (GO:0001921)2.48037790
102endocytic recycling (GO:0032456)2.47860419
103decidualization (GO:0046697)2.47715841
104cortical actin cytoskeleton organization (GO:0030866)2.47170126
105endodermal cell differentiation (GO:0035987)2.46523180
106regulation of synapse maturation (GO:0090128)2.46488018
107regulation of chemokine biosynthetic process (GO:0045073)2.45479103
108extracellular matrix disassembly (GO:0022617)2.43751633
109response to acidic pH (GO:0010447)2.43591976
110cell migration involved in heart development (GO:0060973)2.41318469
111positive regulation of tumor necrosis factor biosynthetic process (GO:0042535)2.41187975
112focal adhesion assembly (GO:0048041)2.41139442
113cell-substrate adherens junction assembly (GO:0007045)2.41139442
114positive regulation of monocyte chemotaxis (GO:0090026)2.41069999
115nucleosome disassembly (GO:0006337)2.40691318
116protein-DNA complex disassembly (GO:0032986)2.40691318
117positive regulation of transcription regulatory region DNA binding (GO:2000679)2.40414116
118lipopolysaccharide-mediated signaling pathway (GO:0031663)2.40279830
119cortical cytoskeleton organization (GO:0030865)2.39545292
120response to progesterone (GO:0032570)2.39538658
121regulation of early endosome to late endosome transport (GO:2000641)2.39235590
122negative regulation of interleukin-2 production (GO:0032703)2.38639497
123Wnt signaling pathway, planar cell polarity pathway (GO:0060071)2.38490910
124negative regulation of focal adhesion assembly (GO:0051895)2.38269146
125negative regulation of cell junction assembly (GO:1901889)2.38269146
126negative regulation of adherens junction organization (GO:1903392)2.38269146
127cell communication by electrical coupling (GO:0010644)2.38161480
128regulation of macrophage cytokine production (GO:0010935)2.37970313
129negative regulation of mRNA processing (GO:0050686)2.37865008
130negative regulation of smooth muscle cell migration (GO:0014912)2.37400667
131response to thyroid hormone (GO:0097066)2.36814467
132regulation of mononuclear cell migration (GO:0071675)2.36690134
133cell communication by electrical coupling involved in cardiac conduction (GO:0086064)2.36660312
134negative regulation of vascular endothelial growth factor receptor signaling pathway (GO:0030948)2.36631609
135endothelial cell chemotaxis (GO:0035767)2.36158358
136negative regulation of blood vessel endothelial cell migration (GO:0043537)2.36035526
137regulation of stem cell maintenance (GO:2000036)2.35719342
138regulation of extracellular matrix disassembly (GO:0010715)2.35544565
139apoptotic process involved in morphogenesis (GO:0060561)2.34275130
140regulation of apoptotic process involved in morphogenesis (GO:1902337)2.34173467
141signal complex assembly (GO:0007172)2.33873009
142neuromuscular process controlling balance (GO:0050885)2.33671741
143regulation of monocyte chemotaxis (GO:0090025)2.33617596
144cell proliferation involved in metanephros development (GO:0072203)2.32656167
145regulation of mammary gland epithelial cell proliferation (GO:0033599)2.32216126
146viral transcription (GO:0019083)2.31926591
147regulation of establishment of planar polarity (GO:0090175)2.31606588
148oligosaccharide catabolic process (GO:0009313)2.31490812
149protein targeting to plasma membrane (GO:0072661)2.31357104
150layer formation in cerebral cortex (GO:0021819)2.30650302
151intrinsic apoptotic signaling pathway in response to endoplasmic reticulum stress (GO:0070059)2.29588348
152establishment of monopolar cell polarity (GO:0061162)2.28863568
153establishment or maintenance of monopolar cell polarity (GO:0061339)2.28863568
154regulation of cell migration involved in sprouting angiogenesis (GO:0090049)2.28844817
155positive regulation of protein export from nucleus (GO:0046827)2.28754520
156cellular response to nutrient (GO:0031670)2.28292683
157actin filament bundle organization (GO:0061572)2.28003028
158actin filament bundle assembly (GO:0051017)2.28003028
159lens fiber cell development (GO:0070307)2.27885528
160negative regulation of erythrocyte differentiation (GO:0045647)2.25860771
161wound healing, spreading of epidermal cells (GO:0035313)2.25271844
162maternal placenta development (GO:0001893)2.25042191
163non-canonical Wnt signaling pathway (GO:0035567)2.24668824
164regulation of protein heterodimerization activity (GO:0043497)2.23357261
165cytokine production involved in immune response (GO:0002367)2.22455937
166nodal signaling pathway (GO:0038092)2.22199315
167stress fiber assembly (GO:0043149)2.21344892
168substrate adhesion-dependent cell spreading (GO:0034446)2.20960711
169neuronal action potential propagation (GO:0019227)2.19779444
170dosage compensation (GO:0007549)2.19516317
171G-protein coupled receptor signaling pathway coupled to cGMP nucleotide second messenger (GO:00071992.19178905
172regulation of integrin activation (GO:0033623)2.18151992
173apoptotic cell clearance (GO:0043277)2.18042900
174peptidyl-arginine methylation (GO:0018216)2.17814977
175peptidyl-arginine N-methylation (GO:0035246)2.17814977
176positive regulation of dendrite morphogenesis (GO:0050775)2.17076754
177C4-dicarboxylate transport (GO:0015740)2.15943284
178anatomical structure regression (GO:0060033)2.15937915
179heparan sulfate proteoglycan biosynthetic process (GO:0015012)2.15792282
180regulation of cellular senescence (GO:2000772)2.15603329
181translational termination (GO:0006415)2.15595851

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1NUCKS1_24931609_ChIP-Seq_HEPATOCYTES_Mouse2.85158129
2TP63_17297297_ChIP-ChIP_HaCaT_Human2.77623559
3E2F7_22180533_ChIP-Seq_HELA_Human2.64170297
4KDM2B_26808549_Chip-Seq_SUP-B15_Human2.60064501
5FOXM1_23109430_ChIP-Seq_U2OS_Human2.52216746
6EZH2_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse2.51554233
7MYC_22102868_ChIP-Seq_BL_Human2.47887050
8ZFP281_18358816_ChIP-ChIP_MESCs_Mouse2.43742690
9EGR1_19374776_ChIP-ChIP_THP-1_Human2.40876472
10KDM2B_26808549_Chip-Seq_DND41_Human2.40541483
11VDR_21846776_ChIP-Seq_THP-1_Human2.35926916
12ELK3_25401928_ChIP-Seq_HUVEC_Human2.34720384
13ZFP281_18757296_ChIP-ChIP_E14_Mouse2.33925882
14RARG_19884340_ChIP-ChIP_MEFs_Mouse2.33078231
15IKZF1_21737484_ChIP-ChIP_HCT116_Human2.29467485
16LXR_22292898_ChIP-Seq_THP-1_Human2.28066226
17EKLF_21900194_ChIP-Seq_ERYTHROCYTE_Mouse2.27684782
18ZFP281_27345836_Chip-Seq_ESCs_Mouse2.12612475
19KDM2B_26808549_Chip-Seq_SIL-ALL_Human2.12320411
20ZNF263_19887448_ChIP-Seq_K562_Human2.07325182
21WT1_20215353_ChIP-ChIP_NEPHRON_PROGENITOR_Mouse2.03614252
22THRA_23701648_ChIP-Seq_CEREBELLUM_Mouse2.03299618
23BP1_19119308_ChIP-ChIP_Hs578T_Human1.94731571
24KDM2B_26808549_Chip-Seq_K562_Human1.93512867
25EP300_20729851_ChIP-Seq_FORBRAIN_MIDBRAIN_LIMB_HEART_Mouse1.92130853
26TCF7_22412390_ChIP-Seq_EML_Mouse1.89867162
27MYCN_19997598_ChIP-ChIP_NEUROBLASTOMA_Human1.87068232
28RUNX2_24764292_ChIP-Seq_MC3T3_Mouse1.82637562
29KDM2B_26808549_Chip-Seq_JURKAT_Human1.80886916
30ESR2_21235772_ChIP-Seq_MCF-7_Human1.79629659
31TBP_23326641_ChIP-Seq_C3H10T1-2_Mouse1.76572171
32RUNX1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.74919676
33KDM2B_26808549_Chip-Seq_HPB-ALL_Human1.64188364
34TRIM28_21343339_ChIP-Seq_HEK293_Human1.62726934
35NANOG_18700969_ChIP-ChIP_MESCs_Mouse1.59687565
36* PPARG_19300518_ChIP-PET_3T3-L1_Mouse1.57675322
37TP53_22127205_ChIP-Seq_IMR90_Human1.56145154
38TP53_20018659_ChIP-ChIP_R1E_Mouse1.55722210
39RACK7_27058665_Chip-Seq_MCF-7_Human1.55168383
40SMAD3_22036565_ChIP-Seq_ESCs_Mouse1.55083127
41DMRT1_23473982_ChIP-Seq_TESTES_Mouse1.54148256
42MYC_19079543_ChIP-ChIP_MESCs_Mouse1.52851260
43P300_27058665_Chip-Seq_ZR-75-30cells_Human1.51138957
44* SOX9_25088423_ChIP-ChIP_EMBRYONIC_GONADS_Mouse1.47884274
45ERG_21242973_ChIP-ChIP_JURKAT_Human1.47279243
46MYC_18555785_ChIP-Seq_MESCs_Mouse1.43860597
47* EGR1_20690147_ChIP-Seq_ERYTHROLEUKEMIA_Human1.42214388
48TCF3_18467660_ChIP-ChIP_MESCs_Mouse1.41162803
49* VDR_24763502_ChIP-Seq_THP-1_Human1.39652693
50KLF4_18358816_ChIP-ChIP_MESCs_Mouse1.38455439
51* RUNX1_20887958_ChIP-Seq_HPC-7_Mouse1.36029197
52TRP63_18441228_ChIP-ChIP_KERATINOCYTES_Mouse1.34598289
53UBF1/2_26484160_Chip-Seq_HMEC-DERIVED_Human1.33342840
54STAT6_21828071_ChIP-Seq_BEAS2B_Human1.33092857
55RELA_24523406_ChIP-Seq_FIBROSARCOMA_Human1.31142613
56CCND1_20090754_ChIP-ChIP_RETINA_Mouse1.30668346
57ATF3_27146783_Chip-Seq_COLON_Human1.30550919
58BRD4_27068464_Chip-Seq_AML-cells_Mouse1.28940062
59SMRT_22465074_ChIP-Seq_MACROPHAGES_Mouse1.27920947
60SRY_25088423_ChIP-ChIP_EMBRYONIC_GONADS_Mouse1.27400111
61POU5F1_18700969_ChIP-ChIP_MESCs_Mouse1.27208977
62UBF1/2_26484160_Chip-Seq_HMECs_Human1.27074338
63ELF1_20517297_ChIP-Seq_JURKAT_Human1.26272853
64UTX_26944678_Chip-Seq_JUKART_Human1.25308433
65PU.1_20513432_ChIP-Seq_MACROPHAGES_Mouse1.25243536
66NCOR_22465074_ChIP-Seq_MACROPHAGES_Mouse1.25120186
67SALL4_18804426_ChIP-ChIP_MESCs_Mouse1.23210240
68ZIC3_20872845_ChIP-ChIP_MESCs_Mouse1.23195283
69KLF6_26769127_Chip-Seq_PDAC-Cell_line_Human1.22876591
70NCOR1_26117541_ChIP-Seq_K562_Human1.22143793
71DACH1_20351289_ChIP-Seq_MDA-MB-231_Human1.21772049
72DNAJC2_21179169_ChIP-ChIP_NT2_Human1.21425797
73TP53_23651856_ChIP-Seq_MEFs_Mouse1.21377272
74SMC1_22415368_ChIP-Seq_MEFs_Mouse1.19521633
75ZNF652_21678463_ChIP-ChIP_ZR75-1_Human1.19072903
76CEBPB_24764292_ChIP-Seq_MC3T3_Mouse1.18972434
77MAF_26560356_Chip-Seq_TH1_Human1.18312352
78TCF21_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human1.18046286
79TCF3_18692474_ChIP-Seq_MEFs_Mouse1.18030982
80PPARD_23176727_ChIP-Seq_KERATINOCYTES_Mouse1.17746575
81HIF1A_21447827_ChIP-Seq_MCF-7_Human1.17371631
82P68_20966046_ChIP-Seq_HELA_Human1.16748551
83SMC3_22415368_ChIP-Seq_MEFs_Mouse1.16623079
84SMAD1_18555785_ChIP-Seq_MESCs_Mouse1.16369365
85* P63_26484246_Chip-Seq_KERATINOCYTES_Human1.15634516
86VDR_23401126_ChIP-Seq_LCL-AND-THP1_Human1.15470026
87CTCF_27219007_Chip-Seq_ERYTHROID_Human1.14602391
88HOXD13_18407260_ChIP-ChIP_DEVELOPING-LIMBS_Mouse1.11657023
89TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat1.10230622
90CTCF_27219007_Chip-Seq_Bcells_Human1.09899366
91SRY_22984422_ChIP-ChIP_TESTIS_Rat1.09823377
92MEIS1_20887958_ChIP-Seq_HPC-7_Mouse1.09312127
93GATA2_21571218_ChIP-Seq_MEGAKARYOCYTES_Human1.08575431
94TCFAP2C_20176728_ChIP-ChIP_TROPHOBLAST_STEM_CELLS_Mouse1.08094877
95* RUNX1_22412390_ChIP-Seq_EML_Mouse1.07603404
96NFIB_24661679_ChIP-Seq_LUNG_Mouse1.07492024
97MYB_21317192_ChIP-Seq_ERMYB_Mouse1.07403631
98CLOCK_20551151_ChIP-Seq_293T_Human1.06219330
99BCOR_27268052_Chip-Seq_Bcells_Human1.05939826
100XRN2_22483619_ChIP-Seq_HELA_Human1.04840412
101SA1_27219007_Chip-Seq_ERYTHROID_Human1.04645406
102TET1_21490601_ChIP-Seq_MESCs_Mouse1.04394014
103E2A_27217539_Chip-Seq_RAMOS-Cell_line_Human1.04256237
104CREB1_26743006_Chip-Seq_LNCaP_Human1.03511783
105CEBPB_21427703_ChIP-Seq_3T3-L1_Mouse1.02528401
106NR0B1_18358816_ChIP-ChIP_MESCs_Mouse1.02388844
107ASXL1_24218140_ChIP-Seq_BMDM_Mouse1.02147141
108SPI1_23127762_ChIP-Seq_K562_Human1.01387540
109TFAP2C_20629094_ChIP-Seq_MCF-7_Human1.00063283
110* TP63_22573176_ChIP-Seq_HFKS_Human0.99560938
111SOX2_18358816_ChIP-ChIP_MESCs_Mouse0.99433920
112EZH2_18974828_ChIP-Seq_MESCs_Mouse0.99142677
113RNF2_18974828_ChIP-Seq_MESCs_Mouse0.99142677
114CREB1_23762244_ChIP-Seq_HIPPOCAMPUS_Rat0.98694320
115MAF_26560356_Chip-Seq_TH2_Human0.98125577
116SMC4_20622854_ChIP-Seq_HELA_Human0.97555892
117* CTCF_18555785_ChIP-Seq_MESCs_Mouse0.97053205
118PU.1_20176806_ChIP-Seq_MACROPHAGES_Mouse0.96951454
119GATA1_19941827_ChIP-Seq_MEL_Mouse0.96825537
120* CREB1_26743006_Chip-Seq_LNCaP-abl_Human0.96727682
121TP63_19390658_ChIP-ChIP_HaCaT_Human0.96598048
122GATA2_21666600_ChIP-Seq_HMVEC_Human0.96142357
123MECOM_23826213_ChIP-Seq_KASUMI_Mouse0.96000883
124ESR1_15608294_ChIP-ChIP_MCF-7_Human0.95999125
125CEBPB_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse0.95741817
126TFAP2A_17053090_ChIP-ChIP_MCF-7_Human0.95341245
127CREB1_20920259_ChIP-Seq_GC1-SPG_Mouse0.95265412
128* KLF4_18555785_ChIP-Seq_MESCs_Mouse0.94846561
129NR1H3_23393188_ChIP-Seq_ATHEROSCLEROTIC-FOAM_Human0.94798856
130OLIG2_26023283_ChIP-Seq_AINV15_Mouse0.94648829
131KLF4_26769127_Chip-Seq_PDAC-Cell_line_Human0.93986322
132KLF4_19030024_ChIP-ChIP_MESCs_Mouse0.92749524
133SETDB1_19884255_ChIP-Seq_MESCs_Mouse0.92736266
134BCL6_27268052_Chip-Seq_Bcells_Human0.91855646
135TET1_21451524_ChIP-Seq_MESCs_Mouse0.91392835
136ELF3_26769127_Chip-Seq_PDAC-Cell_line_Human0.89939295

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0005058_abnormal_lysosome_morphology4.87901661
2MP0003705_abnormal_hypodermis_morpholog3.79253225
3MP0009840_abnormal_foam_cell3.33347200
4MP0008438_abnormal_cutaneous_collagen3.24849600
5MP0005623_abnormal_meninges_morphology3.05786135
6MP0010030_abnormal_orbit_morphology2.75084631
7MP0003303_peritoneal_inflammation2.69622722
8MP0004145_abnormal_muscle_electrophysio2.45022511
9MP0003283_abnormal_digestive_organ2.41945198
10MP0003279_aneurysm2.34174436
11MP0004859_abnormal_synaptic_plasticity2.25824286
12MP0005451_abnormal_body_composition2.22320281
13MP0009278_abnormal_bone_marrow2.19347004
14MP0008569_lethality_at_weaning2.14953339
15MP0009046_muscle_twitch2.10751255
16MP0000751_myopathy2.09089504
17MP0000343_altered_response_to2.02596453
18MP0003300_gastrointestinal_ulcer2.01639209
19MP0001542_abnormal_bone_strength2.01580214
20MP0000733_abnormal_muscle_development1.98967335
21MP0008260_abnormal_autophagy1.96312960
22MP0005503_abnormal_tendon_morphology1.94344191
23MP0003329_amyloid_beta_deposits1.89719245
24MP0001958_emphysema1.89031767
25MP0003385_abnormal_body_wall1.85818261
26MP0003191_abnormal_cellular_cholesterol1.84957949
27MP0003453_abnormal_keratinocyte_physiol1.84912339
28MP0000604_amyloidosis1.83743129
29MP0002089_abnormal_postnatal_growth/wei1.83265641
30MP0003436_decreased_susceptibility_to1.80160897
31MP0010352_gastrointestinal_tract_polyps1.78036833
32MP0004272_abnormal_basement_membrane1.70258068
33MP0002877_abnormal_melanocyte_morpholog1.67849926
34MP0003075_altered_response_to1.66588269
35MP0006082_CNS_inflammation1.61938345
36MP0003828_pulmonary_edema1.61704801
37MP0002998_abnormal_bone_remodeling1.57029227
38MP0000747_muscle_weakness1.56351119
39MP0005076_abnormal_cell_differentiation1.55030798
40MP0003566_abnormal_cell_adhesion1.52033292
41MP0004858_abnormal_nervous_system1.46781397
42MP0004233_abnormal_muscle_weight1.45800149
43MP0001348_abnormal_lacrimal_gland1.45380599
44MP0005409_darkened_coat_color1.44301159
45MP0010368_abnormal_lymphatic_system1.43973542
46MP0005275_abnormal_skin_tensile1.43704093
47MP0002282_abnormal_trachea_morphology1.37233094
48MP0002653_abnormal_ependyma_morphology1.36957938
49MP0003091_abnormal_cell_migration1.36497428
50MP0005023_abnormal_wound_healing1.35288067
51MP0002060_abnormal_skin_morphology1.35172663
52MP0005595_abnormal_vascular_smooth1.34878450
53MP0001533_abnormal_skeleton_physiology1.33160382
54MP0002419_abnormal_innate_immunity1.32492710
55MP0001849_ear_inflammation1.32453480
56MP0000537_abnormal_urethra_morphology1.31697066
57MP0008007_abnormal_cellular_replicative1.31081063
58MP0009053_abnormal_anal_canal1.29084533
59MP0003634_abnormal_glial_cell1.27856224
60MP0000428_abnormal_craniofacial_morphol1.26457652
61MP0003115_abnormal_respiratory_system1.26135319
62MP0005508_abnormal_skeleton_morphology1.26082828
63MP0002932_abnormal_joint_morphology1.25637704
64MP0004808_abnormal_hematopoietic_stem1.24787920
65MP0002896_abnormal_bone_mineralization1.24196055
66MP0000749_muscle_degeneration1.23240894
67MP0002184_abnormal_innervation1.19067361
68MP0010307_abnormal_tumor_latency1.17585680
69MP0002148_abnormal_hypersensitivity_rea1.17042826
70MP0002249_abnormal_larynx_morphology1.16584164
71MP0003448_altered_tumor_morphology1.16336928
72MP0002332_abnormal_exercise_endurance1.16152568
73MP0004197_abnormal_fetal_growth/weight/1.15611481
74MP0000579_abnormal_nail_morphology1.14885138
75MP0004947_skin_inflammation1.14218686
76MP0000534_abnormal_ureter_morphology1.13687076
77MP0005257_abnormal_intraocular_pressure1.12449396
78MP0000049_abnormal_middle_ear1.12168032
79MP0000350_abnormal_cell_proliferation1.11596202
80MP0003942_abnormal_urinary_system1.09936474
81MP0002925_abnormal_cardiovascular_devel1.07658141
82MP0004185_abnormal_adipocyte_glucose1.07263175
83MP0005083_abnormal_biliary_tract1.07230184
84MP0005390_skeleton_phenotype1.07123848
85MP0002085_abnormal_embryonic_tissue1.06643118
86MP0000003_abnormal_adipose_tissue1.05892505
87MP0002084_abnormal_developmental_patter1.04057985
88MP0009384_cardiac_valve_regurgitation1.00537378
89MP0005397_hematopoietic_system_phenotyp1.00095825
90MP0001545_abnormal_hematopoietic_system1.00095825
91MP0003111_abnormal_nucleus_morphology0.98587142
92MP0001299_abnormal_eye_distance/0.97694847
93MP0009250_abnormal_appendicular_skeleto0.97576836
94MP0001879_abnormal_lymphatic_vessel0.97349736
95MP0005464_abnormal_platelet_physiology0.97149168
96MP0005165_increased_susceptibility_to0.95454339
97MP0000920_abnormal_myelination0.94392093
98MP0009764_decreased_sensitivity_to0.93896463
99MP0003119_abnormal_digestive_system0.93778716
100MP0005375_adipose_tissue_phenotype0.93419482
101MP0001853_heart_inflammation0.91510201
102MP0001697_abnormal_embryo_size0.91048722
103MP0000767_abnormal_smooth_muscle0.90546333
104MP0006054_spinal_hemorrhage0.90400311
105MP0004087_abnormal_muscle_fiber0.90349236
106MP0002114_abnormal_axial_skeleton0.89835146
107MP0001293_anophthalmia0.89304402
108MP0001915_intracranial_hemorrhage0.88826998
109MP0003935_abnormal_craniofacial_develop0.88617438
110MP0002254_reproductive_system_inflammat0.87860815
111MP0003632_abnormal_nervous_system0.86880984
112MP0005025_abnormal_response_to0.86531479
113MP0002086_abnormal_extraembryonic_tissu0.85785551
114MP0003861_abnormal_nervous_system0.85228059
115MP0003950_abnormal_plasma_membrane0.83516076
116MP0001614_abnormal_blood_vessel0.83484549
117MP0008770_decreased_survivor_rate0.82912190
118MP0000750_abnormal_muscle_regeneration0.82892606
119MP0003755_abnormal_palate_morphology0.82620912
120MP0002111_abnormal_tail_morphology0.82538533
121MP0002933_joint_inflammation0.82478437
122MP0002080_prenatal_lethality0.82039421
123MP0003690_abnormal_glial_cell0.82007836
124MP0003635_abnormal_synaptic_transmissio0.81704016
125MP0003984_embryonic_growth_retardation0.81464511
126MP0005380_embryogenesis_phenotype0.81392449
127MP0001672_abnormal_embryogenesis/_devel0.81392449
128MP0002116_abnormal_craniofacial_bone0.80453588
129MP0003795_abnormal_bone_structure0.80329341
130MP0002396_abnormal_hematopoietic_system0.79950554
131MP0002088_abnormal_embryonic_growth/wei0.79527577
132MP0000759_abnormal_skeletal_muscle0.78940713
133MP0004510_myositis0.78166129
134MP0000762_abnormal_tongue_morphology0.77671409
135MP0001216_abnormal_epidermal_layer0.76855021
136MP0003172_abnormal_lysosome_physiology0.76582962
137MP0000432_abnormal_head_morphology0.76238449
138MP0001730_embryonic_growth_arrest0.75951128
139MP0003077_abnormal_cell_cycle0.75147978
140MP0001243_abnormal_dermal_layer0.74970985
141MP0000955_abnormal_spinal_cord0.74591868
142MP0000858_altered_metastatic_potential0.74232472
143MP0000685_abnormal_immune_system0.73472850
144MP0005197_abnormal_uvea_morphology0.73459490
145MP0002092_abnormal_eye_morphology0.73283141
146MP0002295_abnormal_pulmonary_circulatio0.73277031
147MP0003123_paternal_imprinting0.72693627
148MP0000467_abnormal_esophagus_morphology0.72113801
149MP0004084_abnormal_cardiac_muscle0.71640117
150MP0004957_abnormal_blastocyst_morpholog0.71082064
151MP0005167_abnormal_blood-brain_barrier0.70971934
152MP0003045_fibrosis0.70662617
153MP0008874_decreased_physiological_sensi0.69885791
154MP0001175_abnormal_lung_morphology0.69700346
155MP0002128_abnormal_blood_circulation0.69384052
156MP0000569_abnormal_digit_pigmentation0.68935479
157MP0010630_abnormal_cardiac_muscle0.68213944
158MP0002113_abnormal_skeleton_development0.67891802
159MP0004133_heterotaxia0.67368975
160MP0005166_decreased_susceptibility_to0.67325040
161MP0003122_maternal_imprinting0.66676039
162MP0000681_abnormal_thyroid_gland0.66260446
163MP0005330_cardiomyopathy0.65307641
164MP0000678_abnormal_parathyroid_gland0.64620063
165MP0002796_impaired_skin_barrier0.63975310
166MP0005193_abnormal_anterior_eye0.62891430

Predicted human phenotypes

RankGene SetZ-score
1Abnormality of glycolipid metabolism (HP:0010969)4.98177319
2Abnormality of liposaccharide metabolism (HP:0010968)4.98177319
3Abnormality of glycosphingolipid metabolism (HP:0004343)4.98177319
4Shallow orbits (HP:0000586)4.88281923
5Protrusio acetabuli (HP:0003179)4.87798329
6Increased cerebral lipofuscin (HP:0011813)3.83886614
7Premature rupture of membranes (HP:0001788)3.76987367
8Cerebral aneurysm (HP:0004944)3.61580628
9Dysostosis multiplex (HP:0000943)3.60351466
10Action tremor (HP:0002345)3.50591800
11Broad metatarsal (HP:0001783)3.47425139
12Annular pancreas (HP:0001734)3.36169789
13Axonal loss (HP:0003447)3.30640988
14Increased neuronal autofluorescent lipopigment (HP:0002074)3.29875694
15Neurofibrillary tangles (HP:0002185)3.24771660
16Nuclear cataract (HP:0100018)3.10195094
17Distal lower limb muscle weakness (HP:0009053)3.05193543
18Type 1 muscle fiber predominance (HP:0003803)3.03544113
19Progressive cerebellar ataxia (HP:0002073)3.01305573
20Increased connective tissue (HP:0009025)3.01073111
21Hemiplegia (HP:0002301)2.85275637
22Distal lower limb amyotrophy (HP:0008944)2.80559971
23Bladder diverticulum (HP:0000015)2.78205635
24Pointed chin (HP:0000307)2.76415576
25Dysmetric saccades (HP:0000641)2.75930471
26Hyperacusis (HP:0010780)2.75922565
27Vacuolated lymphocytes (HP:0001922)2.75081303
28Abnormality of polysaccharide metabolism (HP:0011012)2.72205235
29Abnormality of glycosaminoglycan metabolism (HP:0004371)2.72205235
30Abnormality of mucopolysaccharide metabolism (HP:0011020)2.72205235
31Renal duplication (HP:0000075)2.72053394
32Difficulty climbing stairs (HP:0003551)2.66905585
33Loss of speech (HP:0002371)2.66536145
34Ankle contracture (HP:0006466)2.65440126
35Cerebral inclusion bodies (HP:0100314)2.64946516
36Increased variability in muscle fiber diameter (HP:0003557)2.64149512
37Genu recurvatum (HP:0002816)2.63460820
38Upper motor neuron abnormality (HP:0002127)2.60743239
39Mucopolysacchariduria (HP:0008155)2.60403123
40Urinary glycosaminoglycan excretion (HP:0003541)2.60403123
41Abnormality of the lower motor neuron (HP:0002366)2.55371803
42Hand muscle atrophy (HP:0009130)2.55323460
43Natal tooth (HP:0000695)2.55296160
44Abnormality of skeletal muscle fiber size (HP:0012084)2.52329981
45Short 4th metacarpal (HP:0010044)2.51285607
46Aplasia/Hypoplasia of the 4th metacarpal (HP:0010042)2.51285607
47Radial bowing (HP:0002986)2.50561248
48Bowel diverticulosis (HP:0005222)2.46108048
49Distal upper limb amyotrophy (HP:0007149)2.44994033
50Upper limb amyotrophy (HP:0009129)2.44994033
51Achilles tendon contracture (HP:0001771)2.44572607
52Centrally nucleated skeletal muscle fibers (HP:0003687)2.41402977
53Short nail (HP:0001799)2.41386189
54Intracellular accumulation of autofluorescent lipopigment storage material (HP:0003204)2.41012842
55Supranuclear gaze palsy (HP:0000605)2.38723801
56Impaired smooth pursuit (HP:0007772)2.36045926
57Ulnar bowing (HP:0003031)2.33201961
58Apathy (HP:0000741)2.29706939
59Joint stiffness (HP:0001387)2.28153330
60Diminished motivation (HP:0000745)2.27261133
61Bowed forearm bones (HP:0003956)2.26651557
62Bowing of the arm (HP:0006488)2.26651557
63Dilatation of the ascending aorta (HP:0005111)2.25784482
64Asymmetric septal hypertrophy (HP:0001670)2.24571591
65Slender build (HP:0001533)2.22154025
66Abnormality of ocular smooth pursuit (HP:0000617)2.18311171
67Genetic anticipation (HP:0003743)2.18109315
68Generalized amyotrophy (HP:0003700)2.16351815
69Amyloidosis (HP:0011034)2.16275854
70Mildly elevated creatine phosphokinase (HP:0008180)2.15489275
71Thin bony cortex (HP:0002753)2.12078821
72Aortic aneurysm (HP:0004942)2.11645871
73Turricephaly (HP:0000262)2.11456095
74Primitive reflexes (palmomental, snout, glabellar) (HP:0002476)2.11066465
75Round ear (HP:0100830)2.11014454
76Peritonitis (HP:0002586)2.07530935
77Aortic dissection (HP:0002647)2.06156829
78Scanning speech (HP:0002168)2.05725799
79Lower limb amyotrophy (HP:0007210)2.05261283
80Mitral regurgitation (HP:0001653)2.05161893
81Selective tooth agenesis (HP:0001592)2.05147132
82Increased density of long bones (HP:0006392)2.05082800
83Systemic lupus erythematosus (HP:0002725)2.05017682
84J-shaped sella turcica (HP:0002680)2.04321746
85Mitral valve prolapse (HP:0001634)2.04141658
86Deviation of the hallux (HP:0010051)2.04072955
87Fragile skin (HP:0001030)2.03416020
88Ulnar deviation of the wrist (HP:0003049)2.02775676
89Cervical subluxation (HP:0003308)2.01946128
90Myopathic facies (HP:0002058)2.01441043
91Spondylolisthesis (HP:0003302)2.01192121
92Soft skin (HP:0000977)2.00578114
93Trigonocephaly (HP:0000243)1.97686339
94Neuronal loss in central nervous system (HP:0002529)1.97195152
95Abnormality of the Achilles tendon (HP:0005109)1.96577909
96Atrophic scars (HP:0001075)1.96242164
97Insomnia (HP:0100785)1.96007042
98Hallux valgus (HP:0001822)1.93903411
99Blue sclerae (HP:0000592)1.93393134
100Flat cornea (HP:0007720)1.92463756
101Horizontal nystagmus (HP:0000666)1.91438434
102Arnold-Chiari malformation (HP:0002308)1.91267649
103Thick nail (HP:0001805)1.91228970
104Aneurysm (HP:0002617)1.89558331
105Long toe (HP:0010511)1.87534272
106Muscle fiber cytoplasmatic inclusion bodies (HP:0100303)1.87076718
107Spinal cord lesions (HP:0100561)1.86700489
108Syringomyelia (HP:0003396)1.86700489
109Elbow flexion contracture (HP:0002987)1.86336797
110Overriding aorta (HP:0002623)1.86046940
111Broad palm (HP:0001169)1.84887267
112Gaze-evoked nystagmus (HP:0000640)1.84835946
113Muscle fiber inclusion bodies (HP:0100299)1.84067356
114Bulbar palsy (HP:0001283)1.83376986
115Wrist flexion contracture (HP:0001239)1.83323279
116Elfin facies (HP:0004428)1.83127808
117Renovascular hypertension (HP:0100817)1.82725891
118Stridor (HP:0010307)1.82441086
119Abnormality of macrophages (HP:0004311)1.82106278
120Mutism (HP:0002300)1.81528695
121Dysdiadochokinesis (HP:0002075)1.81034829
122Obstructive sleep apnea (HP:0002870)1.80442975
123Abnormality of the 4th metacarpal (HP:0010012)1.80267342
124Spinal canal stenosis (HP:0003416)1.80124222
125Nemaline bodies (HP:0003798)1.79730898
126Visual hallucinations (HP:0002367)1.78541294
127Vertebral compression fractures (HP:0002953)1.78398434
128Abnormality of dentin (HP:0010299)1.78167322
129Coronal craniosynostosis (HP:0004440)1.77522308
130Disinhibition (HP:0000734)1.76650112
131Overgrowth (HP:0001548)1.75344594
132Thoracic kyphosis (HP:0002942)1.75320429
133Broad face (HP:0000283)1.74500947
134Congenital hip dislocation (HP:0001374)1.73113724
135Back pain (HP:0003418)1.72833781
136Polygenic inheritance (HP:0010982)1.71964532
137Prolonged neonatal jaundice (HP:0006579)1.71933046
138Exercise-induced myalgia (HP:0003738)1.71890181
139Postural tremor (HP:0002174)1.69896905
140Milia (HP:0001056)1.69575236
141Broad ribs (HP:0000885)1.69180687
142Arterial tortuosity (HP:0005116)1.68824794
143Spinal rigidity (HP:0003306)1.67571513
144Down-sloping shoulders (HP:0200021)1.67543191
145Increased nuchal translucency (HP:0010880)1.67271596
146Hemiparesis (HP:0001269)1.66838024
147Myocardial infarction (HP:0001658)1.65778597
148Disproportionate tall stature (HP:0001519)1.65765376
149Neonatal short-limb short stature (HP:0008921)1.65476140
150Broad thumb (HP:0011304)1.64687872
151Wormian bones (HP:0002645)1.64675645
152Narrow nasal bridge (HP:0000446)1.64313832
153Myotonia (HP:0002486)1.64217640
154Abnormality of binocular vision (HP:0011514)1.63943997
155Diplopia (HP:0000651)1.63943997
156High pitched voice (HP:0001620)1.63056425
157Hyperparathyroidism (HP:0000843)1.63021522
158Abnormality of the thoracic spine (HP:0100711)1.62911576
159Hyperextensible skin (HP:0000974)1.62522794
160Neoplasm of the heart (HP:0100544)1.61893633
161Broad long bones (HP:0005622)1.61442295
162Nail dystrophy (HP:0008404)1.61275783
163Progressive neurologic deterioration (HP:0002344)1.61044278
164Abnormality of the peritoneum (HP:0002585)1.60592277
165Narrow palate (HP:0000189)1.60329066
166Protruding ear (HP:0000411)1.59185999
167Broad phalanges of the hand (HP:0009768)1.58998194
168Skin tags (HP:0010609)1.52425919
169Congenital glaucoma (HP:0001087)1.51818912
170Slender long bone (HP:0003100)1.50765990
171Broad finger (HP:0001500)1.50589767
172Broad phalanx (HP:0006009)1.49726771
173Vascular tortuosity (HP:0004948)1.49377819

Predicted kinase interactions (KEA)

RankGene SetZ-score
1RIPK14.37803292
2IRAK33.92400909
3TRIB33.83150415
4EEF2K3.00887926
5CAMKK22.78622566
6PKN22.65366203
7DDR22.39076073
8PDGFRA2.31982311
9MAP3K102.30743242
10ARAF2.21637549
11PAK42.15412722
12PTK62.15210552
13CAMKK11.93706951
14SMG11.86819052
15BMX1.69514962
16TYRO31.68883962
17CDK191.67809931
18ICK1.65999275
19TTN1.63501354
20ERN11.62079247
21ABL21.59926336
22WNK11.57924736
23NTRK11.56931425
24TGFBR11.56683211
25NEK21.55527498
26TAOK21.47972227
27LATS21.43569463
28LRRK21.39390161
29EPHB21.39389896
30ALK1.39099049
31MAP3K111.39077220
32PTK21.37275888
33MAP2K31.35990274
34SCYL21.34073314
35TLK11.32020602
36NEK11.25654365
37DYRK1B1.24977642
38PIM21.21323646
39MAP3K31.20266621
40TESK21.20025512
41TGFBR21.16587719
42RPS6KB21.12525537
43RPS6KA21.11967073
44PAK61.11447976
45BRAF1.10956039
46CAMK1D1.10583114
47MATK1.10380044
48STK381.10220785
49KIT1.07720378
50PAK21.03502699
51CDK61.02218767
52EPHA21.01388195
53RPS6KA41.00227029
54ILK0.99345412
55NME20.98746730
56DAPK30.93336042
57CDK120.92580842
58MAP3K130.91997506
59MAP3K60.91649970
60TIE10.85390471
61SIK20.84879913
62PRPF4B0.83118952
63CDK11A0.78990612
64TESK10.77879933
65FLT30.77445781
66BUB10.77022966
67CDK150.75509234
68KSR20.75460432
69MTOR0.74717718
70MINK10.74452937
71KDR0.74036006
72CAMK40.74008899
73RPS6KL10.73957168
74RPS6KC10.73957168
75CDK70.73799060
76MAP3K10.73730991
77IRAK20.73535894
78ZAP700.72923864
79PDPK10.71809755
80EPHB10.69675483
81CDK180.68968039
82UHMK10.68037698
83CDK140.66870323
84ROCK20.66151639
85LMTK20.65926927
86GRK70.63619674
87MAP3K80.62435991
88PRKD20.61318076
89TRPM70.60990011
90ERBB30.59441029
91FGFR10.57428754
92CCNB10.56879401
93CDC70.56066470
94FES0.55968886
95MET0.55819675
96HIPK20.55213046
97RPS6KA60.54115049
98MAPKAPK30.54078298
99MAPK120.53091815
100CAMK10.51866091
101BTK0.51856872
102BLK0.51128992
103PAK10.51094628
104PDGFRB0.50943497
105TAOK10.50746314
106CAMK2G0.50745947
107PRKCH0.50301532
108SRC0.50064874
109MAPKAPK50.48900574
110IRAK40.48711604
111PTK2B0.48264723
112MAP3K140.48178504
113DYRK30.48100127
114MAP3K90.47371558
115CDK40.47241337
116MST1R0.46939865
117SIK10.46379197
118MAPK40.45945091
119FGR0.45597314
120MAPK70.45497758
121TBK10.45022482
122CAMK1G0.44876642
123CSF1R0.44801404
124MKNK10.44126714
125CHUK0.44085666
126MAP2K20.43852099
127PRKD30.42719306
128CDC42BPA0.42258239
129PHKG10.41423441
130PHKG20.41423441
131LIMK10.41305940
132CSK0.40747760
133ERBB20.40351856
134RET0.38844421
135PRKD10.37275843
136DMPK0.37229879
137CDK20.37151006
138MOS0.36777766
139PRKG20.36772038
140MARK20.34830683

Predicted pathways (KEGG)

RankGene SetZ-score
1Other glycan degradation_Homo sapiens_hsa005113.91408514
2Glycosaminoglycan degradation_Homo sapiens_hsa005312.99137033
3Lysosome_Homo sapiens_hsa041422.92098973
4Bacterial invasion of epithelial cells_Homo sapiens_hsa051001.95112170
5Proteoglycans in cancer_Homo sapiens_hsa052051.80737374
6Long-term depression_Homo sapiens_hsa047301.80365925
7Prion diseases_Homo sapiens_hsa050201.79787697
8Chronic myeloid leukemia_Homo sapiens_hsa052201.64686897
9Long-term potentiation_Homo sapiens_hsa047201.55877940
10Vibrio cholerae infection_Homo sapiens_hsa051101.55877183
11Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006041.49353391
12Bladder cancer_Homo sapiens_hsa052191.42673333
13Basal cell carcinoma_Homo sapiens_hsa052171.41081820
14DNA replication_Homo sapiens_hsa030301.39054800
15Hedgehog signaling pathway_Homo sapiens_hsa043401.34861759
16Focal adhesion_Homo sapiens_hsa045101.34630054
17Toll-like receptor signaling pathway_Homo sapiens_hsa046201.33074965
18Hippo signaling pathway_Homo sapiens_hsa043901.32956794
19Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa049611.31983205
20Malaria_Homo sapiens_hsa051441.31411348
21Pertussis_Homo sapiens_hsa051331.30560868
22Phagosome_Homo sapiens_hsa041451.30370397
23Shigellosis_Homo sapiens_hsa051311.29926477
24Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005331.29898904
25Glioma_Homo sapiens_hsa052141.29404271
26Notch signaling pathway_Homo sapiens_hsa043301.28409730
27Butirosin and neomycin biosynthesis_Homo sapiens_hsa005241.27063112
28AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa049331.26462937
29Fc gamma R-mediated phagocytosis_Homo sapiens_hsa046661.26462397
30Nicotine addiction_Homo sapiens_hsa050331.24882246
31MicroRNAs in cancer_Homo sapiens_hsa052061.23357667
32VEGF signaling pathway_Homo sapiens_hsa043701.20013959
33Spliceosome_Homo sapiens_hsa030401.19472745
34* Glutamatergic synapse_Homo sapiens_hsa047241.17983640
35Neurotrophin signaling pathway_Homo sapiens_hsa047221.17680925
36Gap junction_Homo sapiens_hsa045401.17324540
37Small cell lung cancer_Homo sapiens_hsa052221.16653372
38Galactose metabolism_Homo sapiens_hsa000521.15804030
39Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa005201.15011005
40Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate_Homo sapiens_hsa005321.14756864
41Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa051201.14308910
42mTOR signaling pathway_Homo sapiens_hsa041501.13143849
43Tuberculosis_Homo sapiens_hsa051521.13040425
44Estrogen signaling pathway_Homo sapiens_hsa049151.10644008
45Non-small cell lung cancer_Homo sapiens_hsa052231.07958202
46Base excision repair_Homo sapiens_hsa034101.06445460
47Rheumatoid arthritis_Homo sapiens_hsa053231.05708447
48ECM-receptor interaction_Homo sapiens_hsa045121.04875237
49Aldosterone synthesis and secretion_Homo sapiens_hsa049251.03306985
50Amoebiasis_Homo sapiens_hsa051461.02626990
51GnRH signaling pathway_Homo sapiens_hsa049121.02499369
52Circadian entrainment_Homo sapiens_hsa047131.02386619
53Phospholipase D signaling pathway_Homo sapiens_hsa040721.02370264
54Central carbon metabolism in cancer_Homo sapiens_hsa052301.02096716
55Pentose phosphate pathway_Homo sapiens_hsa000300.99002122
56HTLV-I infection_Homo sapiens_hsa051660.96665532
57Acute myeloid leukemia_Homo sapiens_hsa052210.96289126
58Oocyte meiosis_Homo sapiens_hsa041140.95470126
59Platelet activation_Homo sapiens_hsa046110.95347420
60Sphingolipid signaling pathway_Homo sapiens_hsa040710.94029605
61Toxoplasmosis_Homo sapiens_hsa051450.93071952
62Apoptosis_Homo sapiens_hsa042100.92705888
63Colorectal cancer_Homo sapiens_hsa052100.92631789
64Cell cycle_Homo sapiens_hsa041100.92621301
65Melanogenesis_Homo sapiens_hsa049160.92077789
66Retrograde endocannabinoid signaling_Homo sapiens_hsa047230.90142387
67Fc epsilon RI signaling pathway_Homo sapiens_hsa046640.89563237
68Adrenergic signaling in cardiomyocytes_Homo sapiens_hsa042610.88912708
69Oxytocin signaling pathway_Homo sapiens_hsa049210.88137294
70Thyroid hormone signaling pathway_Homo sapiens_hsa049190.87986553
71Wnt signaling pathway_Homo sapiens_hsa043100.87315378
72Dilated cardiomyopathy_Homo sapiens_hsa054140.87176391
73Leukocyte transendothelial migration_Homo sapiens_hsa046700.87048668
74Adherens junction_Homo sapiens_hsa045200.86445161
75Rap1 signaling pathway_Homo sapiens_hsa040150.86222605
76Phosphatidylinositol signaling system_Homo sapiens_hsa040700.85482236
77p53 signaling pathway_Homo sapiens_hsa041150.85362020
78Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049640.84087691
79Salivary secretion_Homo sapiens_hsa049700.84055813
80Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa045500.84011915
81Endometrial cancer_Homo sapiens_hsa052130.82860284
82Gastric acid secretion_Homo sapiens_hsa049710.82852222
83Protein processing in endoplasmic reticulum_Homo sapiens_hsa041410.82814438
84Other types of O-glycan biosynthesis_Homo sapiens_hsa005140.82076076
85Longevity regulating pathway - mammal_Homo sapiens_hsa042110.81896036
86HIF-1 signaling pathway_Homo sapiens_hsa040660.81890700
87Chagas disease (American trypanosomiasis)_Homo sapiens_hsa051420.80679320
88Progesterone-mediated oocyte maturation_Homo sapiens_hsa049140.80206545
89Regulation of actin cytoskeleton_Homo sapiens_hsa048100.80137096
90mRNA surveillance pathway_Homo sapiens_hsa030150.79922903
91Amyotrophic lateral sclerosis (ALS)_Homo sapiens_hsa050140.79878333
92Ribosome_Homo sapiens_hsa030100.79390722
93Arrhythmogenic right ventricular cardiomyopathy (ARVC)_Homo sapiens_hsa054120.78963384
94Pancreatic cancer_Homo sapiens_hsa052120.78288449
95Axon guidance_Homo sapiens_hsa043600.76988505
96TGF-beta signaling pathway_Homo sapiens_hsa043500.76932393
97Synaptic vesicle cycle_Homo sapiens_hsa047210.76839488
98Salmonella infection_Homo sapiens_hsa051320.76308204
99Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa049600.76168459
100Pathways in cancer_Homo sapiens_hsa052000.76045745
101Endocytosis_Homo sapiens_hsa041440.75716506
102B cell receptor signaling pathway_Homo sapiens_hsa046620.75608674
103Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa005340.74967914
104Mismatch repair_Homo sapiens_hsa034300.74237711
105ErbB signaling pathway_Homo sapiens_hsa040120.71408103
106Melanoma_Homo sapiens_hsa052180.70929950
107Hepatitis B_Homo sapiens_hsa051610.70123791
108Collecting duct acid secretion_Homo sapiens_hsa049660.69899652
109Leishmaniasis_Homo sapiens_hsa051400.69233006
110Sphingolipid metabolism_Homo sapiens_hsa006000.68904670
111Hypertrophic cardiomyopathy (HCM)_Homo sapiens_hsa054100.67843744
112Tight junction_Homo sapiens_hsa045300.67606813
113Vasopressin-regulated water reabsorption_Homo sapiens_hsa049620.67506937
114Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa047500.66700471
115Pathogenic Escherichia coli infection_Homo sapiens_hsa051300.66451576
116GABAergic synapse_Homo sapiens_hsa047270.66173582
117Fructose and mannose metabolism_Homo sapiens_hsa000510.65929564
118Insulin signaling pathway_Homo sapiens_hsa049100.65925020
119Transcriptional misregulation in cancer_Homo sapiens_hsa052020.65745664
120TNF signaling pathway_Homo sapiens_hsa046680.65599342
121Renal cell carcinoma_Homo sapiens_hsa052110.65502062
122MAPK signaling pathway_Homo sapiens_hsa040100.65393288
123Viral carcinogenesis_Homo sapiens_hsa052030.65389827
124Thyroid cancer_Homo sapiens_hsa052160.65348489
125Sulfur relay system_Homo sapiens_hsa041220.64465950
126Osteoclast differentiation_Homo sapiens_hsa043800.64309961
127Thyroid hormone synthesis_Homo sapiens_hsa049180.63331094
128RIG-I-like receptor signaling pathway_Homo sapiens_hsa046220.62348754
129Adipocytokine signaling pathway_Homo sapiens_hsa049200.58147455
130Hepatitis C_Homo sapiens_hsa051600.57708091
131NOD-like receptor signaling pathway_Homo sapiens_hsa046210.55938515
132Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006030.55769726
133PI3K-Akt signaling pathway_Homo sapiens_hsa041510.54638039
134Regulation of lipolysis in adipocytes_Homo sapiens_hsa049230.54303304
135Staphylococcus aureus infection_Homo sapiens_hsa051500.53673079
136Prolactin signaling pathway_Homo sapiens_hsa049170.49859637
137Legionellosis_Homo sapiens_hsa051340.48561058
138NF-kappa B signaling pathway_Homo sapiens_hsa040640.47202473
139Renin-angiotensin system_Homo sapiens_hsa046140.45666329
140Chemokine signaling pathway_Homo sapiens_hsa040620.45274424

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