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Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: No gene information available for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1cilium or flagellum-dependent cell motility (GO:0001539)6.68329875
2ribosomal small subunit biogenesis (GO:0042274)6.25949289
3axonemal dynein complex assembly (GO:0070286)5.82244269
4viral transcription (GO:0019083)5.71806827
5translational termination (GO:0006415)5.51066542
6motile cilium assembly (GO:0044458)5.42263155
7acrosome reaction (GO:0007340)5.36876710
8negative regulation of glycogen biosynthetic process (GO:0045719)5.21416973
9sperm motility (GO:0030317)5.14089680
10sperm-egg recognition (GO:0035036)4.88795168
11acrosome assembly (GO:0001675)4.81888110
12spermatid nucleus differentiation (GO:0007289)4.81042703
13multicellular organism reproduction (GO:0032504)4.79033841
14cell wall macromolecule metabolic process (GO:0044036)4.78465733
15cell wall macromolecule catabolic process (GO:0016998)4.78465733
16tolerance induction (GO:0002507)4.63573272
17DNA methylation involved in gamete generation (GO:0043046)4.62986583
18viral life cycle (GO:0019058)4.54243331
19SRP-dependent cotranslational protein targeting to membrane (GO:0006614)4.44323553
20galactose catabolic process (GO:0019388)4.43615819
21cell-cell recognition (GO:0009988)4.39743304
22translational elongation (GO:0006414)4.39501068
23protein targeting to ER (GO:0045047)4.38522165
24cotranslational protein targeting to membrane (GO:0006613)4.36790280
25erythrose 4-phosphate/phosphoenolpyruvate family amino acid catabolic process (GO:1902222)4.35131911
26L-phenylalanine catabolic process (GO:0006559)4.35131911
27piRNA metabolic process (GO:0034587)4.26017021
28establishment of protein localization to endoplasmic reticulum (GO:0072599)4.23901339
29male meiosis (GO:0007140)4.23435213
30binding of sperm to zona pellucida (GO:0007339)4.21215364
31maturation of SSU-rRNA (GO:0030490)4.18211338
32epithelial cilium movement (GO:0003351)4.17353541
33regulation of energy homeostasis (GO:2000505)4.17340928
34nuclear-transcribed mRNA catabolic process, nonsense-mediated decay (GO:0000184)4.17077773
35erythrose 4-phosphate/phosphoenolpyruvate family amino acid metabolic process (GO:1902221)4.16479320
36L-phenylalanine metabolic process (GO:0006558)4.16479320
37ribosomal small subunit assembly (GO:0000028)4.14476457
38cilium movement (GO:0003341)4.13175317
39L-fucose catabolic process (GO:0042355)4.10930562
40fucose catabolic process (GO:0019317)4.10930562
41L-fucose metabolic process (GO:0042354)4.10930562
42fusion of sperm to egg plasma membrane (GO:0007342)4.09390695
43negative regulation of cardiac muscle hypertrophy (GO:0010614)4.06568746
44cellular protein complex disassembly (GO:0043624)4.05137861
45protein localization to endoplasmic reticulum (GO:0070972)4.01309825
46platelet dense granule organization (GO:0060155)3.97528030
47prostate gland growth (GO:0060736)3.97232471
48regulation of cilium movement (GO:0003352)3.96195129
49intraciliary transport (GO:0042073)3.92721589
50regulation of cellular respiration (GO:0043457)3.90160406
51regulation of interleukin-12 biosynthetic process (GO:0045075)3.80451129
52negative regulation of glycogen metabolic process (GO:0070874)3.79430216
53spermatid development (GO:0007286)3.74951950
54protein complex disassembly (GO:0043241)3.72500611
55ribonucleoprotein complex biogenesis (GO:0022613)3.71828561
56cysteine metabolic process (GO:0006534)3.70319109
57epithelial cilium movement involved in determination of left/right asymmetry (GO:0060287)3.69174939
58negative regulation of muscle hypertrophy (GO:0014741)3.65590709
59centriole assembly (GO:0098534)3.64462957
60forebrain morphogenesis (GO:0048853)3.62378465
61positive regulation of transcription from RNA polymerase II promoter in response to stress (GO:003603.60958890
62regulation of oxidative stress-induced neuron death (GO:1903203)3.59140214
63reproduction (GO:0000003)3.56249570
64macromolecular complex disassembly (GO:0032984)3.47284679
65CDP-diacylglycerol biosynthetic process (GO:0016024)3.42969999
66microtubule depolymerization (GO:0007019)3.41220713
67rRNA methylation (GO:0031167)3.40712074
68daunorubicin metabolic process (GO:0044597)3.39560541
69polyketide metabolic process (GO:0030638)3.39560541
70doxorubicin metabolic process (GO:0044598)3.39560541
71presynaptic membrane assembly (GO:0097105)3.39434431
72membrane tubulation (GO:0097320)3.36801573
73plasma membrane fusion (GO:0045026)3.35460577
74single fertilization (GO:0007338)3.34661538
75intra-S DNA damage checkpoint (GO:0031573)3.30243210
76sperm capacitation (GO:0048240)3.27070742
77ribosomal large subunit biogenesis (GO:0042273)3.24973380
78translational initiation (GO:0006413)3.24356129
79synaptonemal complex organization (GO:0070193)3.19123249
80positive regulation of T cell apoptotic process (GO:0070234)3.18120616
81regulation of transcription from RNA polymerase II promoter in response to oxidative stress (GO:00433.13976417
82ribosome biogenesis (GO:0042254)3.13341508
83tRNA splicing, via endonucleolytic cleavage and ligation (GO:0006388)3.12793963
84RNA splicing, via endonucleolytic cleavage and ligation (GO:0000394)3.12793963
85dentate gyrus development (GO:0021542)3.11938668
86negative regulation of transcription by competitive promoter binding (GO:0010944)3.06922774
87CDP-diacylglycerol metabolic process (GO:0046341)3.06382948
88synapsis (GO:0007129)3.04590298
89fucosylation (GO:0036065)3.04515941
90N-terminal protein amino acid acetylation (GO:0006474)3.04191814
91aromatic amino acid family catabolic process (GO:0009074)3.04148478
92ventricular system development (GO:0021591)3.03357000
93positive regulation by symbiont of host defense response (GO:0052509)3.02213426
94modulation by symbiont of host defense response (GO:0052031)3.02213426
95modulation by organism of immune response of other organism involved in symbiotic interaction (GO:003.02213426
96modulation by organism of defense response of other organism involved in symbiotic interaction (GO:03.02213426
97positive regulation by organism of defense response of other organism involved in symbiotic interact3.02213426
98modulation by symbiont of host immune response (GO:0052553)3.02213426
99synaptonemal complex assembly (GO:0007130)3.01830855
100interleukin-6-mediated signaling pathway (GO:0070102)3.01751987
101negative regulation of phagocytosis (GO:0050765)3.01533279
102centriole replication (GO:0007099)3.01049925
103very-low-density lipoprotein particle assembly (GO:0034379)3.00677261
104protein polyglutamylation (GO:0018095)2.97675142
105positive regulation of protein homooligomerization (GO:0032464)2.97269829
106chromosome organization involved in meiosis (GO:0070192)2.96555084
107response to pheromone (GO:0019236)2.96433568
108negative regulation of execution phase of apoptosis (GO:1900118)2.95153715
109protein K11-linked deubiquitination (GO:0035871)2.94812717
110protein targeting to membrane (GO:0006612)2.93755910
111rRNA modification (GO:0000154)2.93422732
112mRNA splice site selection (GO:0006376)2.92610340
113positive regulation of lymphocyte apoptotic process (GO:0070230)2.90104674
114regulation of mitotic cell cycle spindle assembly checkpoint (GO:0090266)2.88725168
115regulation of mitotic spindle checkpoint (GO:1903504)2.88725168
116cilium assembly (GO:0042384)2.87813465
117desmosome organization (GO:0002934)2.85184385
118regulation of chromatin binding (GO:0035561)2.84721034
119ubiquinone metabolic process (GO:0006743)2.84038815
120endosome to pigment granule transport (GO:0043485)2.83928677
121endosome to melanosome transport (GO:0035646)2.83928677
122cilium organization (GO:0044782)2.82984998
123negative regulation of potassium ion transport (GO:0043267)2.82782032
124negative regulation of myeloid cell apoptotic process (GO:0033033)2.82475481
125protein localization to endosome (GO:0036010)2.81527865
126male gamete generation (GO:0048232)2.80652077
127spermatogenesis (GO:0007283)2.80563221
128ubiquinone biosynthetic process (GO:0006744)2.80139352
129positive regulation of gamma-delta T cell activation (GO:0046645)2.79885187
130calcium ion-dependent exocytosis (GO:0017156)2.78349584
131definitive hemopoiesis (GO:0060216)2.78030436
132glutathione biosynthetic process (GO:0006750)2.73483006
133cellular component biogenesis (GO:0044085)2.72812435
134regulation of hypersensitivity (GO:0002883)2.72299599
135valine metabolic process (GO:0006573)2.70891670
136sexual reproduction (GO:0019953)2.70130057
137inner ear receptor cell differentiation (GO:0060113)2.69248124
138presynaptic membrane organization (GO:0097090)2.67952900
139plasma lipoprotein particle assembly (GO:0034377)2.67385754
140nephron epithelium morphogenesis (GO:0072088)2.67347696
141nephron tubule morphogenesis (GO:0072078)2.67347696
142nuclear-transcribed mRNA catabolic process (GO:0000956)2.65586928
143tyrosine metabolic process (GO:0006570)2.65167698
144replication fork processing (GO:0031297)2.64065729
145protein localization to cilium (GO:0061512)2.63776677
146histone H2A acetylation (GO:0043968)2.63701499
147histone H3-K9 methylation (GO:0051567)2.63386005
148secretory granule organization (GO:0033363)2.61904505
149gamete generation (GO:0007276)2.60813965
150meiotic chromosome segregation (GO:0045132)2.60391655
151DNA synthesis involved in DNA repair (GO:0000731)2.59031246
152glandular epithelial cell differentiation (GO:0002067)2.57868697
153tRNA methylation (GO:0030488)2.57701973
154protein targeting to Golgi (GO:0000042)2.57354147
155megakaryocyte development (GO:0035855)2.56791683
156fucose metabolic process (GO:0006004)2.56740865
157protein K48-linked deubiquitination (GO:0071108)2.55917457
158galactose metabolic process (GO:0006012)2.54731030
159mRNA catabolic process (GO:0006402)2.54534287
160cellular ketone body metabolic process (GO:0046950)2.53958412
161establishment of protein localization to Golgi (GO:0072600)2.53163965
162phosphatidylethanolamine biosynthetic process (GO:0006646)2.52752188
163negative regulation of neurotransmitter secretion (GO:0046929)2.52656529
164regulation of meiosis I (GO:0060631)2.50705514
165fertilization (GO:0009566)2.50239416
166N-acetylneuraminate metabolic process (GO:0006054)2.50205951
167DNA ligation (GO:0006266)2.49936156
168protein carboxylation (GO:0018214)2.49644686
169peptidyl-glutamic acid carboxylation (GO:0017187)2.49644686
170negative regulation of inflammatory response to antigenic stimulus (GO:0002862)2.48273713
171epithelial cell differentiation involved in prostate gland development (GO:0060742)2.48038004
172proline biosynthetic process (GO:0006561)2.46746973
173quinone biosynthetic process (GO:1901663)2.46273005
174nonribosomal peptide biosynthetic process (GO:0019184)2.45600813
175low-density lipoprotein particle remodeling (GO:0034374)2.44582055
176organic cation transport (GO:0015695)2.44250188
177pentose metabolic process (GO:0019321)2.44127728
178regulation of nuclear cell cycle DNA replication (GO:0033262)2.40560096
179regulation of spindle checkpoint (GO:0090231)2.39938571
180maintenance of fidelity involved in DNA-dependent DNA replication (GO:0045005)2.39597652
181meiotic nuclear division (GO:0007126)2.38091310
182germ cell development (GO:0007281)2.37536288
183snRNA processing (GO:0016180)2.36796369
184kinetochore assembly (GO:0051382)2.36350465
185nucleosome disassembly (GO:0006337)2.35312663
186protein-DNA complex disassembly (GO:0032986)2.35312663
187lymphoid progenitor cell differentiation (GO:0002320)2.35274482
188aminoglycoside antibiotic metabolic process (GO:0030647)2.34604500
189kinetochore organization (GO:0051383)2.31392870
190intracellular pH reduction (GO:0051452)2.30813596
191poly(A)+ mRNA export from nucleus (GO:0016973)2.28865582
192cellular response to interleukin-15 (GO:0071350)2.27417313
193inositol phosphate catabolic process (GO:0071545)2.26334936
194neutrophil mediated immunity (GO:0002446)2.25873173
195DNA strand renaturation (GO:0000733)2.25702711

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1SOX9_22984422_ChIP-ChIP_TESTIS_Rat6.09305006
2TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse3.70012659
3MYBL1_21750041_ChIP-ChIP_SPERMATOCYTES_Mouse3.43589154
4TP63_17297297_ChIP-ChIP_HaCaT_Human3.11720446
5IRF8_22096565_ChIP-ChIP_GC-B_Human2.98588811
6GLI1_17442700_ChIP-ChIP_MESCs_Mouse2.74262670
7PCGF2_27294783_Chip-Seq_ESCs_Mouse2.69801244
8GBX2_23144817_ChIP-Seq_PC3_Human2.64391574
9FLI1_27457419_Chip-Seq_LIVER_Mouse2.57942764
10BCL11B_21912641_ChIP-Seq_STHDH_STRIUM_Mouse2.54632068
11PRDM16_22522345_ChIP-ChIP_PALATE_MESENCHYMAL_Mouse2.48687890
12EZH2_22144423_ChIP-Seq_EOC_Human2.46492349
13E2F7_22180533_ChIP-Seq_HELA_Human2.41446645
14DMRT1_21621532_ChIP-ChIP_FETAL_Ovary2.40114345
15PCGF2_27294783_Chip-Seq_NPCs_Mouse2.35583201
16TBP_23326641_ChIP-Seq_C3H10T1-2_Mouse2.35336504
17ZFP57_27257070_Chip-Seq_ESCs_Mouse2.31937747
18CIITA_18437201_ChIP-ChIP_Raji_B_and_iDC_Human2.30821445
19SRY_22984422_ChIP-ChIP_TESTIS_Rat2.14840250
20VDR_22108803_ChIP-Seq_LS180_Human2.09339418
21KDM5A_27292631_Chip-Seq_BREAST_Human2.09256019
22PPARD_23208498_ChIP-Seq_MDA-MB-231_Human2.05599401
23NFE2_27457419_Chip-Seq_LIVER_Mouse2.03941586
24IGF1R_20145208_ChIP-Seq_DFB_Human2.02074561
25LXR_22292898_ChIP-Seq_THP-1_Human2.01067500
26ESR1_17901129_ChIP-ChIP_LIVER_Mouse1.97000552
27SUZ12_27294783_Chip-Seq_NPCs_Mouse1.96161267
28CBX2_27304074_Chip-Seq_ESCs_Mouse1.93078816
29GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.92582821
30MYCN_21190229_ChIP-Seq_SHEP-21N_Human1.92309801
31POU3F2_20337985_ChIP-ChIP_501MEL_Human1.88159643
32XRN2_22483619_ChIP-Seq_HELA_Human1.86310685
33MAF_26560356_Chip-Seq_TH2_Human1.84961759
34MYC_22102868_ChIP-Seq_BL_Human1.82940291
35TAF15_26573619_Chip-Seq_HEK293_Human1.82704478
36STAT3_18555785_Chip-Seq_ESCs_Mouse1.82069747
37RNF2_27304074_Chip-Seq_NSC_Mouse1.80836309
38BCL6_27268052_Chip-Seq_Bcells_Human1.78964467
39* BCOR_27268052_Chip-Seq_Bcells_Human1.78628698
40* ELF1_20517297_ChIP-Seq_JURKAT_Human1.77872110
41SUZ12_18555785_Chip-Seq_ESCs_Mouse1.74711437
42NANOG_18555785_Chip-Seq_ESCs_Mouse1.74464882
43P53_22387025_ChIP-Seq_ESCs_Mouse1.73849769
44SPI1_22096565_ChIP-ChIP_GC-B_Mouse1.73704061
45TCFCP2L1_18555785_Chip-Seq_ESCs_Mouse1.73417937
46EBF1_22473956_ChIP-Seq_BONE_MARROW_Mouse1.71696556
47* VDR_21846776_ChIP-Seq_THP-1_Human1.71590394
48FUS_26573619_Chip-Seq_HEK293_Human1.70991553
49E2F1_18555785_Chip-Seq_ESCs_Mouse1.68736431
50SCL_19346495_ChIP-Seq_HPC-7_Human1.67820293
51CEBPA_23403033_ChIP-Seq_LIVER_Mouse1.65358123
52EZH2_27294783_Chip-Seq_NPCs_Mouse1.62991453
53CMYC_18555785_Chip-Seq_ESCs_Mouse1.62602159
54SMARCD1_25818293_ChIP-Seq_ESCs_Mouse1.60657201
55NOTCH1_21737748_ChIP-Seq_TLL_Human1.60039200
56* P68_20966046_ChIP-Seq_HELA_Human1.59953026
57NMYC_18555785_Chip-Seq_ESCs_Mouse1.59190755
58P300_18555785_Chip-Seq_ESCs_Mouse1.58572088
59* P300_27268052_Chip-Seq_Bcells_Human1.58522954
60OCT4_18555785_Chip-Seq_ESCs_Mouse1.58408788
61BMI1_23680149_ChIP-Seq_NPCS_Mouse1.56457359
62EBF1_22473956_ChIP-Seq_LYMPHODE_Mouse1.56424249
63TP53_22127205_ChIP-Seq_IMR90_Human1.53644598
64E2A_27217539_Chip-Seq_RAMOS-Cell_line_Human1.53223581
65TAL1_26923725_Chip-Seq_HPCs_Mouse1.53156316
66RUNX1_27457419_Chip-Seq_LIVER_Mouse1.52860637
67KLF4_18555785_Chip-Seq_ESCs_Mouse1.51011211
68NCOR1_26117541_ChIP-Seq_K562_Human1.50431703
69ESRRB_18555785_Chip-Seq_ESCs_Mouse1.49910175
70ELF1_17652178_ChIP-ChIP_JURKAT_Human1.49733251
71GATA1_19941826_ChIP-Seq_K562_Human1.49153678
72SOX2_18555785_Chip-Seq_ESCs_Mouse1.49134232
73RCOR1_19997604_ChIP-ChIP_NEURONS_Mouse1.48329670
74RXR_22158963_ChIP-Seq_LIVER_Mouse1.47370542
75* RAC3_21632823_ChIP-Seq_H3396_Human1.47347158
76P300_19829295_ChIP-Seq_ESCs_Human1.45388825
77LMO2_26923725_Chip-Seq_MACROPHAGESS_Mouse1.42877634
78PU1_27457419_Chip-Seq_LIVER_Mouse1.42729363
79HCFC1_20581084_ChIP-Seq_MESCs_Mouse1.40771589
80ZFX_18555785_Chip-Seq_ESCs_Mouse1.40136035
81IRF8_22096565_ChIP-ChIP_GC-B_Mouse1.40101059
82RACK7_27058665_Chip-Seq_MCF-7_Human1.39909053
83PPARA_22158963_ChIP-Seq_LIVER_Mouse1.39630697
84MAF_26560356_Chip-Seq_TH1_Human1.39576292
85SA1_27219007_Chip-Seq_ERYTHROID_Human1.39482064
86JARID1A_20064375_ChIP-Seq_MESCs_Mouse1.39173573
87* RXRA_24833708_ChIP-Seq_LIVER_Mouse1.37946597
88SPI1_23127762_ChIP-Seq_K562_Human1.37344775
89EGR1_23403033_ChIP-Seq_LIVER_Mouse1.37198378
90MEIS1_26253404_ChIP-Seq_OPTIC_CUPS_Mouse1.36818265
91SA1_27219007_Chip-Seq_Bcells_Human1.36068128
92CTNNB1_20615089_ChIP-ChIP_FETAL_BRAIN_Human1.35723439
93ERG_20887958_ChIP-Seq_HPC-7_Mouse1.35442664
94* TDRD3_21172665_ChIP-Seq_MCF-7_Human1.34446180
95* RBPJ_21746931_ChIP-Seq_IB4-LCL_Human1.33167487
96ETS1_20019798_ChIP-Seq_JURKAT_Human1.33034455
97CTCF_18555785_Chip-Seq_ESCs_Mouse1.32698085
98SPI1_22790984_ChIP-Seq_ERYTHROLEUKEMIA_Mouse1.32449152
99CEBPB_23403033_ChIP-Seq_LIVER_Mouse1.31421466
100IRF1_21803131_ChIP-Seq_MONOCYTES_Human1.29932934
101ER_23166858_ChIP-Seq_MCF-7_Human1.28854680
102* E2F1_20622854_ChIP-Seq_HELA_Human1.28530805
103SMAD1_18555785_Chip-Seq_ESCs_Mouse1.26794897
104STAT3_22323479_ChIP-Seq_MACROPHAGE_Mouse1.26493426
105ZFP322A_24550733_ChIP-Seq_MESCs_Mouse1.26154225
106IRF1_19129219_ChIP-ChIP_H3396_Human1.25602793
107CEBPB_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.23616150
108* EBNA2_21746931_ChIP-Seq_IB4-LCL_Human1.23570769
109EWS_26573619_Chip-Seq_HEK293_Human1.23289341
110* GATA6_25053715_ChIP-Seq_YYC3_Human1.23175873
111* FOXP1_21924763_ChIP-Seq_HESCs_Human1.22871024
112GABP_17652178_ChIP-ChIP_JURKAT_Human1.22522411
113LYL1_20887958_ChIP-Seq_HPC-7_Mouse1.21164443
114CDKN2AIP_20523734_ChIP-Seq_CORTICAL_Neurons1.21038901
115SFPI1_20887958_ChIP-Seq_HPC-7_Mouse1.20461958
116TP63_19390658_ChIP-ChIP_HaCaT_Human1.20311138
117RBPJ_22232070_ChIP-Seq_NCS_Mouse1.20294197
118CDX2_21402776_ChIP-Seq_INTESTINAL-VILLUS_Mouse1.20042164
119GFI1B_20887958_ChIP-Seq_HPC-7_Mouse1.19984841
120YY1_22570637_ChIP-Seq_MALME-3M_Human1.19383023
121CTBP2_25329375_ChIP-Seq_LNCAP_Human1.18855788
122SMC4_20622854_ChIP-Seq_HELA_Human1.18696416
123STAT6_21828071_ChIP-Seq_BEAS2B_Human1.17962327
124* CTCF_26484167_Chip-Seq_Bcells_Mouse1.17738240
125POU5F1_26923725_Chip-Seq_MESODERM_Mouse1.16759586
126TEAD4_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.16759586
127* CEBPB_24764292_ChIP-Seq_MC3T3_Mouse1.16395660
128CRX_20693478_ChIP-Seq_RETINA_Mouse1.15880385
129* PHF8_20622854_ChIP-Seq_HELA_Human1.14032890
130PDX1_19855005_ChIP-ChIP_MIN6_Mouse1.13451845
131RELA_24523406_ChIP-Seq_FIBROSARCOMA_Human1.13200252
132P63_26484246_Chip-Seq_KERATINOCYTES_Human1.13076955
133OCT4_21477851_ChIP-Seq_ESCs_Mouse1.12022658
134SPI1_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse1.11251054
135UTX_26944678_Chip-Seq_JUKART_Human1.10972035
136THRA_23701648_ChIP-Seq_CEREBELLUM_Mouse1.10108668
137ZNF652_21678463_ChIP-ChIP_ZR75-1_Human1.09965138
138* ERA_21632823_ChIP-Seq_H3396_Human1.09915396
139EGR1_19374776_ChIP-ChIP_THP-1_Human1.09753736
140CEBPD_23245923_ChIP-Seq_MEFs_Mouse1.09443213
141PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human1.08662701
142BCL3_23251550_ChIP-Seq_MUSCLE_Mouse1.08586061
143CREB1_26743006_Chip-Seq_LNCaP_Human1.07925474
144PKCTHETA_26484144_Chip-Seq_BREAST_Human1.07736067
145* MYC_18358816_ChIP-ChIP_MESCs_Mouse1.06464828
146TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat1.06459780
147FOXO3_22982991_ChIP-Seq_MACROPHAGES_Mouse1.06003471
148CTCF_27219007_Chip-Seq_ERYTHROID_Human1.05512403
149SMAD4_21799915_ChIP-Seq_A2780_Human1.05265097
150GATA3_21878914_ChIP-Seq_MCF-7_Human1.05107935
151KDM2B_26808549_Chip-Seq_REH_Human1.05059348
152CTCF_21964334_Chip-Seq_Bcells_Human1.04547659
153TP63_22573176_ChIP-Seq_HFKS_Human1.04444216
154SMAD2/3_21741376_ChIP-Seq_ESCs_Human1.04432243
155TCF4_23295773_ChIP-Seq_U87_Human1.04178507
156SOX9_26525672_Chip-Seq_HEART_Mouse1.03758341
157TAL1_20887958_ChIP-Seq_HPC-7_Mouse1.03483961
158SPI1_23547873_ChIP-Seq_NB4_Human1.03296076
159GABP_19822575_ChIP-Seq_HepG2_Human1.01886559
160SPI1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.01564943
161EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human1.01221452
162HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse1.01123438
163EBNA1_20929547_Chip-Seq_RAJI-cells_Human1.00319991
164* TAF2_19829295_ChIP-Seq_ESCs_Human0.99467435
165FOXP2_21765815_ChIP-ChIP_NEURO2A_Mouse0.99295212
166SOX6_21985497_ChIP-Seq_MYOTUBES_Mouse0.99118833
167GATA4_25053715_ChIP-Seq_YYC3_Human0.98837456
168CHD1_26751641_Chip-Seq_LNCaP_Human0.98723239
169RARA_24833708_ChIP-Seq_LIVER_Mouse0.98647966
170* NANOG_20526341_ChIP-Seq_ESCs_Human0.98556063
171KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human0.98004694
172POU5F1_18555785_ChIP-Seq_MESCs_Mouse0.96963584
173* RUNX1_22897851_ChIP-Seq_JUKARTE6-1_Human0.96834201
174FLI1_20887958_ChIP-Seq_HPC-7_Mouse0.96273725
175LMO2_20887958_ChIP-Seq_HPC-7_Mouse0.96241140
176HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human0.95340117
177STAT3_23295773_ChIP-Seq_U87_Human0.93526565
178CTBP1_25329375_ChIP-Seq_LNCAP_Human0.93080341
179KLF4_25985364_ChIP-Seq_ATHEROSCLEROSIS_LESION_Mouse0.92075346
180HOXB4_20404135_ChIP-ChIP_EML_Mouse0.90340192
181PPARG_23326641_ChIP-Seq_C3H10T1-2_Mouse0.90200494
182MEIS1_20887958_ChIP-Seq_HPC-7_Mouse0.89629314
183OLIG2_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse0.88878944
184GATA1_26923725_Chip-Seq_HPCs_Mouse0.88818194
185CEBPB_26923725_Chip-Seq_MESODERM_Mouse0.88608337
186RUNX1_20887958_ChIP-Seq_HPC-7_Mouse0.88572433
187FOXP3_21729870_ChIP-Seq_TREG_Human0.86761751
188E2F4_17652178_ChIP-ChIP_JURKAT_Human0.86207018
189SRF_21415370_ChIP-Seq_HL-1_Mouse0.86183663
190NOTCH1_17114293_ChIP-ChIP_T-ALL_Human0.85861886

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0008877_abnormal_DNA_methylation4.30385616
2MP0002139_abnormal_hepatobiliary_system4.29630609
3MP0005410_abnormal_fertilization4.19309310
4MP0001188_hyperpigmentation3.66446441
5MP0002837_dystrophic_cardiac_calcinosis3.60941140
6MP0006292_abnormal_olfactory_placode3.28084828
7MP0005409_darkened_coat_color3.13106189
8MP0009379_abnormal_foot_pigmentation3.08281590
9MP0001986_abnormal_taste_sensitivity3.03540425
10MP0003303_peritoneal_inflammation2.49416381
11MP0000566_synostosis2.48128589
12MP0002138_abnormal_hepatobiliary_system2.46388808
13MP0005646_abnormal_pituitary_gland2.33575834
14MP0008058_abnormal_DNA_repair2.28022350
15MP0003698_abnormal_male_reproductive2.26363717
16MP0003195_calcinosis2.24512616
17MP0009697_abnormal_copulation2.22388710
18MP0001984_abnormal_olfaction2.10350062
19MP0000015_abnormal_ear_pigmentation2.09466012
20MP0001929_abnormal_gametogenesis2.00043612
21MP0005058_abnormal_lysosome_morphology1.99237560
22MP0005174_abnormal_tail_pigmentation1.98235334
23MP0003787_abnormal_imprinting1.93772730
24MP0000678_abnormal_parathyroid_gland1.93727254
25MP0003300_gastrointestinal_ulcer1.93218165
26MP0005365_abnormal_bile_salt1.91163252
27MP0002102_abnormal_ear_morphology1.90814471
28MP0001915_intracranial_hemorrhage1.87601744
29MP0005075_abnormal_melanosome_morpholog1.83828333
30MP0005451_abnormal_body_composition1.83179327
31MP0008995_early_reproductive_senescence1.81211504
32MP0002735_abnormal_chemical_nociception1.79351772
33MP0001764_abnormal_homeostasis1.70087858
34MP0002928_abnormal_bile_duct1.64135758
35MP0002210_abnormal_sex_determination1.62348548
36MP0002277_abnormal_respiratory_mucosa1.61075466
37MP0000609_abnormal_liver_physiology1.59489398
38MP0005377_hearing/vestibular/ear_phenot1.56344607
39MP0003878_abnormal_ear_physiology1.56344607
40MP0002736_abnormal_nociception_after1.55515310
41MP0008057_abnormal_DNA_replication1.55240742
42MP0003121_genomic_imprinting1.53810278
43MP0005645_abnormal_hypothalamus_physiol1.53251523
44MP0005220_abnormal_exocrine_pancreas1.52511772
45MP0010386_abnormal_urinary_bladder1.50850973
46MP0002095_abnormal_skin_pigmentation1.48794697
47MP0009333_abnormal_splenocyte_physiolog1.47776907
48MP0000685_abnormal_immune_system1.47593765
49MP0003172_abnormal_lysosome_physiology1.47272274
50MP0004147_increased_porphyrin_level1.46359216
51MP0005379_endocrine/exocrine_gland_phen1.44982897
52MP0003943_abnormal_hepatobiliary_system1.42972196
53MP0010094_abnormal_chromosome_stability1.41335632
54MP0003880_abnormal_central_pattern1.37417094
55MP0003183_abnormal_peptide_metabolism1.36752327
56MP0002160_abnormal_reproductive_system1.35371419
57MP0010155_abnormal_intestine_physiology1.34395640
58MP0003122_maternal_imprinting1.33617276
59MP0001145_abnormal_male_reproductive1.32839828
60MP0002163_abnormal_gland_morphology1.32102984
61MP0002938_white_spotting1.31198534
62MP0001800_abnormal_humoral_immune1.30089388
63MP0002132_abnormal_respiratory_system1.28624504
64MP0002396_abnormal_hematopoietic_system1.27587764
65MP0001968_abnormal_touch/_nociception1.26193156
66MP0003252_abnormal_bile_duct1.24819130
67MP0000631_abnormal_neuroendocrine_gland1.22924153
68MP0004264_abnormal_extraembryonic_tissu1.22918759
69MP0001790_abnormal_immune_system1.21002677
70MP0005387_immune_system_phenotype1.21002677
71MP0004808_abnormal_hematopoietic_stem1.19984684
72MP0001666_abnormal_nutrient_absorption1.18510500
73MP0001346_abnormal_lacrimal_gland1.17754497
74MP0005670_abnormal_white_adipose1.17372984
75MP0004019_abnormal_vitamin_homeostasis1.16834235
76MP0004381_abnormal_hair_follicle1.15948537
77MP0006054_spinal_hemorrhage1.15792049
78MP0005085_abnormal_gallbladder_physiolo1.15094411
79MP0005083_abnormal_biliary_tract1.14891669
80MP0005253_abnormal_eye_physiology1.14880506
81MP0000653_abnormal_sex_gland1.14055424
82MP0004084_abnormal_cardiac_muscle1.13827909
83MP0002723_abnormal_immune_serum1.13645980
84MP0009840_abnormal_foam_cell1.13271496
85MP0003186_abnormal_redox_activity1.13144902
86MP0005310_abnormal_salivary_gland1.12922783
87MP0009765_abnormal_xenobiotic_induced1.11832752
88MP0003806_abnormal_nucleotide_metabolis1.10860327
89MP0002161_abnormal_fertility/fecundity1.08685547
90MP0003693_abnormal_embryo_hatching1.08534894
91MP0010329_abnormal_lipoprotein_level1.07237127
92MP0002075_abnormal_coat/hair_pigmentati1.06780406
93MP0005623_abnormal_meninges_morphology1.06382175
94MP0003011_delayed_dark_adaptation1.05515555
95MP0003786_premature_aging1.05206218
96MP0002148_abnormal_hypersensitivity_rea1.04907493
97MP0005171_absent_coat_pigmentation1.00692387
98MP0005025_abnormal_response_to1.00674623
99MP0001944_abnormal_pancreas_morphology1.00404570
100MP0001186_pigmentation_phenotype1.00373447
101MP0003763_abnormal_thymus_physiology0.99434361
102MP0005394_taste/olfaction_phenotype0.99338221
103MP0005499_abnormal_olfactory_system0.99338221
104MP0005636_abnormal_mineral_homeostasis0.99191209
105MP0001765_abnormal_ion_homeostasis0.98790956
106MP0008469_abnormal_protein_level0.98541610
107MP0001845_abnormal_inflammatory_respons0.97285317
108MP0002876_abnormal_thyroid_physiology0.96958589
109MP0006276_abnormal_autonomic_nervous0.96731338
110MP0009046_muscle_twitch0.96106530
111MP0009745_abnormal_behavioral_response0.95695567
112MP0001905_abnormal_dopamine_level0.95661571
113MP0000372_irregular_coat_pigmentation0.95314150
114MP0008789_abnormal_olfactory_epithelium0.94060609
115MP0005084_abnormal_gallbladder_morpholo0.93899520
116MP0001348_abnormal_lacrimal_gland0.92917137
117MP0001502_abnormal_circadian_rhythm0.92666670
118MP0003656_abnormal_erythrocyte_physiolo0.92274782
119MP0005423_abnormal_somatic_nervous0.92146958
120MP0005448_abnormal_energy_balance0.91132486
121MP0005332_abnormal_amino_acid0.91033048
122MP0002118_abnormal_lipid_homeostasis0.90874190
123MP0002452_abnormal_antigen_presenting0.90581889
124MP0005671_abnormal_response_to0.90472964
125MP0002572_abnormal_emotion/affect_behav0.90043955
126MP0003111_abnormal_nucleus_morphology0.89622311
127MP0000681_abnormal_thyroid_gland0.88981487
128MP0009785_altered_susceptibility_to0.88451489
129MP0005389_reproductive_system_phenotype0.87697513
130MP0002419_abnormal_innate_immunity0.86523328
131MP0005000_abnormal_immune_tolerance0.86422492
132MP0009643_abnormal_urine_homeostasis0.84857097
133MP0005319_abnormal_enzyme/_coenzyme0.84786617
134MP0001873_stomach_inflammation0.84594282
135MP0008007_abnormal_cellular_replicative0.84515354
136MP0001835_abnormal_antigen_presentation0.83482798
137MP0002638_abnormal_pupillary_reflex0.82963868
138MP0000569_abnormal_digit_pigmentation0.82054323
139MP0005334_abnormal_fat_pad0.81834283
140MP0003123_paternal_imprinting0.81518659
141MP0000598_abnormal_liver_morphology0.81506691
142MP0005551_abnormal_eye_electrophysiolog0.81152914
143MP0009115_abnormal_fat_cell0.80887657
144MP0005464_abnormal_platelet_physiology0.80867639
145MP0002557_abnormal_social/conspecific_i0.79684304
146MP0000516_abnormal_urinary_system0.78742761
147MP0005367_renal/urinary_system_phenotyp0.78742761
148MP0005666_abnormal_adipose_tissue0.77620303
149MP0002398_abnormal_bone_marrow0.77387158
150MP0001545_abnormal_hematopoietic_system0.77299851
151MP0005397_hematopoietic_system_phenotyp0.77299851
152MP0002078_abnormal_glucose_homeostasis0.76712628
153MP0009780_abnormal_chondrocyte_physiolo0.76689470
154MP0000049_abnormal_middle_ear0.76627493
155MP0002272_abnormal_nervous_system0.76503647
156MP0001963_abnormal_hearing_physiology0.76116486
157MP0002098_abnormal_vibrissa_morphology0.75859389
158MP0001119_abnormal_female_reproductive0.74588902
159MP0002653_abnormal_ependyma_morphology0.73708212
160MP0004145_abnormal_muscle_electrophysio0.73178261
161MP0004185_abnormal_adipocyte_glucose0.72262359
162MP0005248_abnormal_Harderian_gland0.72041476
163MP0002693_abnormal_pancreas_physiology0.71856012
164MP0001529_abnormal_vocalization0.71414837
165MP0006072_abnormal_retinal_apoptosis0.71225344
166MP0002177_abnormal_outer_ear0.69827829
167MP0002067_abnormal_sensory_capabilities0.69414289
168MP0002063_abnormal_learning/memory/cond0.69372493
169MP0003635_abnormal_synaptic_transmissio0.68730620
170MP0002420_abnormal_adaptive_immunity0.68368677
171MP0001819_abnormal_immune_cell0.68343446
172MP0005167_abnormal_blood-brain_barrier0.68323207
173MP0005647_abnormal_sex_gland0.68051349
174MP0004130_abnormal_muscle_cell0.66757128
175MP0000367_abnormal_coat/_hair0.65840642
176MP0002429_abnormal_blood_cell0.65035892
177MP0000689_abnormal_spleen_morphology0.64871509
178MP0003953_abnormal_hormone_level0.64548723

Predicted human phenotypes

RankGene SetZ-score
1Absent/shortened dynein arms (HP:0200106)6.13922904
2Dynein arm defect of respiratory motile cilia (HP:0012255)6.13922904
3Respiratory insufficiency due to defective ciliary clearance (HP:0200073)5.93243435
4Chronic hepatic failure (HP:0100626)5.69899390
5Abnormality of cells of the erythroid lineage (HP:0012130)5.22307439
6Abnormal number of erythroid precursors (HP:0012131)4.84825359
7Abnormal respiratory motile cilium physiology (HP:0012261)4.76944724
8Abnormal respiratory motile cilium morphology (HP:0005938)4.63433304
9Abnormal respiratory epithelium morphology (HP:0012253)4.63433304
10Abnormal ciliary motility (HP:0012262)4.58489841
11Septate vagina (HP:0001153)4.50278675
12Vacuolated lymphocytes (HP:0001922)3.40281621
13Rhinitis (HP:0012384)3.38197972
14Aplasia/Hypoplasia of the sacrum (HP:0008517)3.30089100
15Tubulointerstitial nephritis (HP:0001970)3.22667614
16Chronic bronchitis (HP:0004469)3.20176233
17Reticulocytopenia (HP:0001896)3.19891643
18Generalized aminoaciduria (HP:0002909)3.12417016
19Intestinal atresia (HP:0011100)3.07203019
20Nephronophthisis (HP:0000090)2.93301618
21Chromosomal breakage induced by crosslinking agents (HP:0003221)2.92718401
22Loss of speech (HP:0002371)2.85331563
23Type I transferrin isoform profile (HP:0003642)2.72270241
24Macrocytic anemia (HP:0001972)2.70211599
25Medial flaring of the eyebrow (HP:0010747)2.69824686
26Premature ovarian failure (HP:0008209)2.68835608
27Hypergonadotropic hypogonadism (HP:0000815)2.68538187
28Vaginal fistula (HP:0004320)2.66971050
29Bronchiectasis (HP:0002110)2.65147845
30Rectovaginal fistula (HP:0000143)2.64514888
31Rectal fistula (HP:0100590)2.64514888
32Absent rod-and cone-mediated responses on ERG (HP:0007688)2.61996479
33True hermaphroditism (HP:0010459)2.58758815
34Acanthocytosis (HP:0001927)2.57059270
35Hypothermia (HP:0002045)2.56303920
36Deep venous thrombosis (HP:0002625)2.53284169
37Abnormality of the renal medulla (HP:0100957)2.53110781
38Parkinsonism with favorable response to dopaminergic medication (HP:0002548)2.46736223
39Pallor (HP:0000980)2.46707333
40Hyperthyroidism (HP:0000836)2.45614825
41Asymmetry of the thorax (HP:0001555)2.43403412
42Prolonged partial thromboplastin time (HP:0003645)2.42637515
43Intestinal fistula (HP:0100819)2.40313019
44Chromsome breakage (HP:0040012)2.39839782
45Abnormal spermatogenesis (HP:0008669)2.39642019
46Abnormality of reticulocytes (HP:0004312)2.38388326
47Poikilocytosis (HP:0004447)2.37310450
48Microvesicular hepatic steatosis (HP:0001414)2.37117483
49Bronchitis (HP:0012387)2.31531251
50Aplasia/Hypoplasia of the uvula (HP:0010293)2.30246163
51Glomerulonephritis (HP:0000099)2.29572905
52Thrombocytosis (HP:0001894)2.29468989
53Abnormality of the ileum (HP:0001549)2.28826935
5411 pairs of ribs (HP:0000878)2.27884551
55Chronic otitis media (HP:0000389)2.25855748
56Thyroiditis (HP:0100646)2.25516072
57Abnormality of the preputium (HP:0100587)2.23315991
58Abnormal protein glycosylation (HP:0012346)2.21859783
59Abnormal glycosylation (HP:0012345)2.21859783
60Abnormal isoelectric focusing of serum transferrin (HP:0003160)2.21859783
61Abnormal protein N-linked glycosylation (HP:0012347)2.21859783
62Severe visual impairment (HP:0001141)2.19218609
63Pancreatic fibrosis (HP:0100732)2.19058582
64Purpura (HP:0000979)2.18795888
65Optic nerve hypoplasia (HP:0000609)2.17576299
66Disinhibition (HP:0000734)2.15966503
67Infertility (HP:0000789)2.15354747
68Delayed epiphyseal ossification (HP:0002663)2.14302448
69Meckel diverticulum (HP:0002245)2.13707023
70Decreased central vision (HP:0007663)2.12585242
71Nephrogenic diabetes insipidus (HP:0009806)2.10952903
72Abnormality of the renal cortex (HP:0011035)2.10948516
73Nasal polyposis (HP:0100582)2.09776032
74Increased neuronal autofluorescent lipopigment (HP:0002074)2.09642518
75Widely patent fontanelles and sutures (HP:0004492)2.07823940
76Abnormality of aromatic amino acid family metabolism (HP:0004338)2.07298123
77Progressive muscle weakness (HP:0003323)2.07133838
78Exocrine pancreatic insufficiency (HP:0001738)2.04956776
79Thyroid-stimulating hormone excess (HP:0002925)2.04627983
80Postaxial foot polydactyly (HP:0001830)2.03930021
81Myelodysplasia (HP:0002863)2.03906821
82Recurrent sinusitis (HP:0011108)2.03261611
83Systemic lupus erythematosus (HP:0002725)2.02876347
84Dysostosis multiplex (HP:0000943)2.02608076
85Attenuation of retinal blood vessels (HP:0007843)2.02395160
86Increased cerebral lipofuscin (HP:0011813)2.02320451
87Metaphyseal irregularity (HP:0003025)2.01792058
88Abnormal hair whorl (HP:0010721)2.01337293
89Febrile seizures (HP:0002373)1.99947886
90Reticulocytosis (HP:0001923)1.99781492
91Potter facies (HP:0002009)1.99250032
92Facial shape deformation (HP:0011334)1.99250032
93Nephroblastoma (Wilms tumor) (HP:0002667)1.96830319
94Vascular calcification (HP:0004934)1.94749737
95Preaxial hand polydactyly (HP:0001177)1.94692909
96Aplastic anemia (HP:0001915)1.94672803
97Clubbing of toes (HP:0100760)1.94558464
98Ectopic kidney (HP:0000086)1.94427111
99Abnormal sex determination (HP:0012244)1.94176699
100Sex reversal (HP:0012245)1.94176699
101Abnormal rod and cone electroretinograms (HP:0008323)1.93248757
102Abnormality of polysaccharide metabolism (HP:0011012)1.93243779
103Abnormality of glycosaminoglycan metabolism (HP:0004371)1.93243779
104Abnormality of mucopolysaccharide metabolism (HP:0011020)1.93243779
105Seborrheic dermatitis (HP:0001051)1.93176190
106Congenital primary aphakia (HP:0007707)1.93041086
107Gastrointestinal stroma tumor (HP:0100723)1.92847202
108Hypophosphatemic rickets (HP:0004912)1.91012996
109Tubulointerstitial abnormality (HP:0001969)1.89947865
110Renal cortical cysts (HP:0000803)1.89867560
111Fibular aplasia (HP:0002990)1.89213274
112Bone marrow hypocellularity (HP:0005528)1.88964990
113Pseudobulbar signs (HP:0002200)1.88934270
114Bony spicule pigmentary retinopathy (HP:0007737)1.88585561
115Polydipsia (HP:0001959)1.88460841
116Abnormal drinking behavior (HP:0030082)1.88460841
117Abnormality of liposaccharide metabolism (HP:0010968)1.88316297
118Abnormality of glycosphingolipid metabolism (HP:0004343)1.88316297
119Abnormality of glycolipid metabolism (HP:0010969)1.88316297
120Molar tooth sign on MRI (HP:0002419)1.87227262
121Abnormality of midbrain morphology (HP:0002418)1.87227262
122Rib fusion (HP:0000902)1.86266384
123Unilateral renal agenesis (HP:0000122)1.86257890
124Chronic diarrhea (HP:0002028)1.85786130
125Abnormality of renal excretion (HP:0011036)1.85128993
126Abnormality of macrophages (HP:0004311)1.85025725
127Glycosuria (HP:0003076)1.84961079
128Abnormality of urine glucose concentration (HP:0011016)1.84961079
129Gait imbalance (HP:0002141)1.83949817
130Male infertility (HP:0003251)1.83263450
131Abnormality of chromosome stability (HP:0003220)1.82750042
132Embryonal renal neoplasm (HP:0011794)1.81757410
133Amelogenesis imperfecta (HP:0000705)1.80834355
134Personality changes (HP:0000751)1.80475013
135Renovascular hypertension (HP:0100817)1.79931360
136Nonprogressive disorder (HP:0003680)1.78803250
137Joint hemorrhage (HP:0005261)1.78728784
138Recurrent gram-negative bacterial infections (HP:0005420)1.78135738
139Pancreatic cysts (HP:0001737)1.77887455
140Abnormality of the diencephalon (HP:0010662)1.77567430
141Aplasia/Hypoplasia of the optic nerve (HP:0008058)1.77557169
142Azoospermia (HP:0000027)1.77091116
143Urinary glycosaminoglycan excretion (HP:0003541)1.76787085
144Mucopolysacchariduria (HP:0008155)1.76787085
145Congenital hepatic fibrosis (HP:0002612)1.76406741
146Elevated circulating parathyroid hormone (PTH) level (HP:0003165)1.75920560
147Submucous cleft hard palate (HP:0000176)1.75623767
148Chronic sinusitis (HP:0011109)1.75383490
149Anophthalmia (HP:0000528)1.75046818
150Abnormality of the parathyroid morphology (HP:0011766)1.74338540
151Epileptic encephalopathy (HP:0200134)1.73685174
152Recurrent bronchitis (HP:0002837)1.72434597
153Abnormality of the carotid arteries (HP:0005344)1.72256663
154Hemorrhage of the eye (HP:0011885)1.71892746
155Enlarged kidneys (HP:0000105)1.70067820
156Type 2 muscle fiber atrophy (HP:0003554)1.68439600
157Recurrent bacterial skin infections (HP:0005406)1.68314600
158Abnormality of chloride homeostasis (HP:0011422)1.66917565
159Obstructive lung disease (HP:0006536)1.66915724
160Chronic obstructive pulmonary disease (HP:0006510)1.66915724
161Metabolic acidosis (HP:0001942)1.66384548
162Rickets (HP:0002748)1.66354850
163Reduced antithrombin III activity (HP:0001976)1.66125929
164Dyschromatopsia (HP:0007641)1.64733104
165Xanthomatosis (HP:0000991)1.63917952
166Abnormality of the common coagulation pathway (HP:0010990)1.63609902
167Pancreatic islet-cell hyperplasia (HP:0004510)1.62952547
168Abnormality of the renal collecting system (HP:0004742)1.62745462
169Absent eyebrow (HP:0002223)1.62517853
170Congenital stationary night blindness (HP:0007642)1.62478309
171Protruding tongue (HP:0010808)1.61579580
172Hyperkalemia (HP:0002153)1.61343589
173Renal dysplasia (HP:0000110)1.61289017
174Abnormal pancreas size (HP:0012094)1.60978762
175Increased corneal curvature (HP:0100692)1.60648125
176Keratoconus (HP:0000563)1.60648125
177Duplication of thumb phalanx (HP:0009942)1.59665011
178Tubular atrophy (HP:0000092)1.58259143
179Postaxial hand polydactyly (HP:0001162)1.57796003
180Abnormality of the gastric mucosa (HP:0004295)1.57786873
181Renal hypoplasia (HP:0000089)1.57764197
182Occipital encephalocele (HP:0002085)1.57251766
183Asplenia (HP:0001746)1.55525121
184Male pseudohermaphroditism (HP:0000037)1.55366636
185Birth length less than 3rd percentile (HP:0003561)1.54654627
186Generalized hypopigmentation of hair (HP:0011358)1.54138126
187Small intestinal stenosis (HP:0012848)1.53372065

Predicted kinase interactions (KEA)

RankGene SetZ-score
1STK163.62853106
2RIPK43.58448232
3CASK3.45772775
4FRK3.25634986
5PASK2.93182282
6CAMKK12.84203973
7MKNK22.82581933
8WNK32.67482645
9MAP2K72.55697783
10TNIK2.38865734
11TXK2.36708581
12AKT32.27675861
13MKNK12.12408705
14LRRK22.10763040
15PRPF4B2.06223594
16MAP3K142.04656752
17IRAK41.83693116
18SGK21.80707934
19BMPR1B1.75010923
20SIK31.70636686
21BRD41.65916725
22CLK11.63409724
23FGFR41.62089228
24SIK21.61093223
25MAPK151.60944341
26PRKAA21.49641518
27MAP3K131.49375844
28EIF2AK11.46942737
29YES11.45476029
30IRAK31.45315675
31ERBB31.42567074
32PIK3CA1.41910364
33CDK121.40510731
34TYRO31.40453482
35TEC1.39340906
36MAPKAPK31.37531542
37EEF2K1.36705672
38MAP3K21.35609338
39SIK11.35533941
40PDK41.33482739
41PDK31.33482739
42NEK61.32193913
43NME21.30415902
44TIE11.26933066
45BRSK21.26630804
46CAMKK21.24165263
47ADRBK21.23746148
48VRK11.23107147
49CAMK1D1.23091373
50GRK11.19078139
51CCNB11.18836302
52MATK1.17486690
53MAPK131.17056004
54CDC71.15329888
55CDK191.15040079
56SGK2231.10605441
57SGK4941.10605441
58PRKD31.08977529
59CDK81.08277685
60WNK11.07316445
61INSRR1.06607900
62ZAK1.05031729
63PLK41.03796233
64SRPK11.01585790
65NTRK31.00681654
66SGK30.98865586
67FGFR30.98664025
68MAP3K40.95484478
69DDR20.94421446
70RPS6KB20.94123021
71EIF2AK30.92921207
72MAP4K10.91327617
73BTK0.89989724
74ATR0.89801812
75MARK30.85997207
76KIT0.82856956
77WNK40.82232038
78TSSK60.81115771
79EIF2AK20.80698567
80PRKCQ0.79908716
81MAP3K70.75515216
82NLK0.75311342
83CAMK1G0.75013453
84MAP3K10.74122270
85DYRK30.72994324
86TGFBR10.71552058
87MAP3K90.70892842
88TRIB30.70123564
89OXSR10.70119660
90STK40.69987394
91CHUK0.68709684
92PDPK10.68456169
93MAPK110.66925281
94NME10.65957414
95RPS6KB10.64569721
96DYRK1B0.62672309
97SYK0.61214497
98MAP3K80.61153420
99TYK20.61074932
100FGFR20.60331985
101BMPR20.59450173
102PLK30.59224529
103IRAK10.58953650
104FES0.58257191
105TAOK30.57420832
106STK380.57336730
107MUSK0.57291585
108IKBKE0.57210825
109CSF1R0.56684385
110MAP2K20.56274201
111HIPK20.55605903
112STK240.55348014
113BLK0.54443766
114ITK0.54084520
115PDK10.52496314
116LCK0.51775772
117PTK60.51712768
118BRAF0.51617609
119ACVR1B0.51009859
120CDK30.50037518
121TLK10.49308263
122KSR20.49224401
123STK38L0.48891457
124CDK70.48689165
125PIM20.47211470
126FGR0.46654229
127MAP2K60.45268095
128FLT30.44907871
129GRK60.43501221
130PRKAA10.42521185
131CSK0.42383960
132NEK20.42011070
133RPS6KA50.41981224
134IKBKB0.41873733
135LYN0.41534564
136CDC42BPA0.41426500
137ICK0.40422153
138BCR0.40224406
139NUAK10.40040648
140PRKCZ0.39820780
141MAP3K110.39625426
142JAK30.38672216
143STK390.38649966
144SGK10.38268706
145IRAK20.37922115
146TESK10.37916293
147MAP4K20.36619582
148RPS6KA60.36498583
149BCKDK0.36006591
150PRKD20.35413753
151PTK2B0.34934661
152ERN10.34887532
153RPS6KA10.34746832
154PRKCE0.33181074
155RPS6KA20.33015238
156PDK20.32508356
157DYRK1A0.30220343
158PLK10.29889628
159PLK20.28498446
160WEE10.28313803
161CSNK2A10.27760910
162ZAP700.27760525
163PIM10.27303373

Predicted pathways (KEGG)

RankGene SetZ-score
1Ribosome_Homo sapiens_hsa030104.48940695
2Fanconi anemia pathway_Homo sapiens_hsa034603.57466222
3Protein export_Homo sapiens_hsa030603.25506508
4Terpenoid backbone biosynthesis_Homo sapiens_hsa009002.62656952
5Homologous recombination_Homo sapiens_hsa034402.58653187
6Steroid biosynthesis_Homo sapiens_hsa001002.46707399
7Sulfur metabolism_Homo sapiens_hsa009202.44920601
8Other glycan degradation_Homo sapiens_hsa005112.41322256
9DNA replication_Homo sapiens_hsa030302.40859169
10Mismatch repair_Homo sapiens_hsa034302.22304165
11Staphylococcus aureus infection_Homo sapiens_hsa051502.19013833
12Base excision repair_Homo sapiens_hsa034102.11534850
13Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006012.09542889
14Basal transcription factors_Homo sapiens_hsa030222.02720741
15Maturity onset diabetes of the young_Homo sapiens_hsa049502.01728963
16SNARE interactions in vesicular transport_Homo sapiens_hsa041301.96309509
17Phototransduction_Homo sapiens_hsa047441.83549690
18Lysosome_Homo sapiens_hsa041421.82074870
19Nicotine addiction_Homo sapiens_hsa050331.76413820
20Non-homologous end-joining_Homo sapiens_hsa034501.70249958
21Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004001.69700166
22Fatty acid biosynthesis_Homo sapiens_hsa000611.54834380
23Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001301.54565828
24Galactose metabolism_Homo sapiens_hsa000521.53796409
25Neuroactive ligand-receptor interaction_Homo sapiens_hsa040801.52708998
26Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005631.50736639
27Complement and coagulation cascades_Homo sapiens_hsa046101.42677204
28Cell cycle_Homo sapiens_hsa041101.41194127
29Purine metabolism_Homo sapiens_hsa002301.40504616
30RNA degradation_Homo sapiens_hsa030181.36353335
31Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005121.34843285
32Acute myeloid leukemia_Homo sapiens_hsa052211.34083304
33Cytosolic DNA-sensing pathway_Homo sapiens_hsa046231.30514789
34Taste transduction_Homo sapiens_hsa047421.29606987
35Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006031.29308251
36Vibrio cholerae infection_Homo sapiens_hsa051101.27048090
37Synthesis and degradation of ketone bodies_Homo sapiens_hsa000721.26559713
38Phenylalanine metabolism_Homo sapiens_hsa003601.26330093
39Fatty acid metabolism_Homo sapiens_hsa012121.26218386
40Morphine addiction_Homo sapiens_hsa050321.25562715
41Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa005201.24644563
42Spliceosome_Homo sapiens_hsa030401.23676360
43Nucleotide excision repair_Homo sapiens_hsa034201.21503512
44Asthma_Homo sapiens_hsa053101.21193351
45Pentose and glucuronate interconversions_Homo sapiens_hsa000401.20103495
46Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049321.19128165
47Olfactory transduction_Homo sapiens_hsa047401.18141244
48Type II diabetes mellitus_Homo sapiens_hsa049301.16649248
49Glycosaminoglycan degradation_Homo sapiens_hsa005311.15978887
50B cell receptor signaling pathway_Homo sapiens_hsa046621.14158462
51Arginine biosynthesis_Homo sapiens_hsa002201.13491471
52Circadian entrainment_Homo sapiens_hsa047131.09949653
53Amphetamine addiction_Homo sapiens_hsa050311.09700899
54Adipocytokine signaling pathway_Homo sapiens_hsa049201.09640592
55Prolactin signaling pathway_Homo sapiens_hsa049171.08298815
56Herpes simplex infection_Homo sapiens_hsa051681.08218899
57Pyrimidine metabolism_Homo sapiens_hsa002401.08202876
58Tyrosine metabolism_Homo sapiens_hsa003501.07790659
59Fat digestion and absorption_Homo sapiens_hsa049751.07512711
60RIG-I-like receptor signaling pathway_Homo sapiens_hsa046221.07476434
61Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008601.06769784
62Insulin secretion_Homo sapiens_hsa049111.05009497
63Retrograde endocannabinoid signaling_Homo sapiens_hsa047231.03895170
64Glycerolipid metabolism_Homo sapiens_hsa005611.02934288
65Type I diabetes mellitus_Homo sapiens_hsa049401.00514387
66N-Glycan biosynthesis_Homo sapiens_hsa005101.00250570
67Insulin resistance_Homo sapiens_hsa049310.98132200
68Fatty acid degradation_Homo sapiens_hsa000710.97927010
69Other types of O-glycan biosynthesis_Homo sapiens_hsa005140.97797421
70Tryptophan metabolism_Homo sapiens_hsa003800.94679035
71TNF signaling pathway_Homo sapiens_hsa046680.94115462
72Measles_Homo sapiens_hsa051620.93703511
73NF-kappa B signaling pathway_Homo sapiens_hsa040640.93515699
74Transcriptional misregulation in cancer_Homo sapiens_hsa052020.92331590
75Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030080.92258972
76Intestinal immune network for IgA production_Homo sapiens_hsa046720.90670663
77Taurine and hypotaurine metabolism_Homo sapiens_hsa004300.90488014
78Sulfur relay system_Homo sapiens_hsa041220.89206609
79Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007600.88426726
80PPAR signaling pathway_Homo sapiens_hsa033200.88073784
81Pantothenate and CoA biosynthesis_Homo sapiens_hsa007700.87963316
82Inflammatory bowel disease (IBD)_Homo sapiens_hsa053210.87856425
83Hematopoietic cell lineage_Homo sapiens_hsa046400.87649658
84Collecting duct acid secretion_Homo sapiens_hsa049660.87421536
85mRNA surveillance pathway_Homo sapiens_hsa030150.86472494
86Primary bile acid biosynthesis_Homo sapiens_hsa001200.82762141
87Glutamatergic synapse_Homo sapiens_hsa047240.82592619
88Natural killer cell mediated cytotoxicity_Homo sapiens_hsa046500.81776151
89Long-term potentiation_Homo sapiens_hsa047200.81404589
90Protein processing in endoplasmic reticulum_Homo sapiens_hsa041410.80733576
91RNA transport_Homo sapiens_hsa030130.80358402
92Rheumatoid arthritis_Homo sapiens_hsa053230.80090040
93Systemic lupus erythematosus_Homo sapiens_hsa053220.79677871
94Serotonergic synapse_Homo sapiens_hsa047260.79509046
95Thyroid cancer_Homo sapiens_hsa052160.79459594
96RNA polymerase_Homo sapiens_hsa030200.79112216
97Regulation of autophagy_Homo sapiens_hsa041400.78947218
98Ascorbate and aldarate metabolism_Homo sapiens_hsa000530.76530054
99Ubiquitin mediated proteolysis_Homo sapiens_hsa041200.75638973
100Cocaine addiction_Homo sapiens_hsa050300.75148593
101Valine, leucine and isoleucine degradation_Homo sapiens_hsa002800.74521189
102Primary immunodeficiency_Homo sapiens_hsa053400.74371094
103Sphingolipid metabolism_Homo sapiens_hsa006000.72501916
104Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa051200.72082009
105Hepatitis C_Homo sapiens_hsa051600.71559202
106NOD-like receptor signaling pathway_Homo sapiens_hsa046210.71053835
107Butanoate metabolism_Homo sapiens_hsa006500.69963610
108Fc epsilon RI signaling pathway_Homo sapiens_hsa046640.69575671
109Allograft rejection_Homo sapiens_hsa053300.68665076
110Oxidative phosphorylation_Homo sapiens_hsa001900.67722751
111Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa009700.67700044
112Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006300.67116667
113Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005330.66712687
114Nitrogen metabolism_Homo sapiens_hsa009100.65532621
115ABC transporters_Homo sapiens_hsa020100.65442038
116Fructose and mannose metabolism_Homo sapiens_hsa000510.65379955
117Alcoholism_Homo sapiens_hsa050340.64437843
118Synaptic vesicle cycle_Homo sapiens_hsa047210.62857683
119Vitamin digestion and absorption_Homo sapiens_hsa049770.61803048
120mTOR signaling pathway_Homo sapiens_hsa041500.61721286
121Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006040.61307654
122Butirosin and neomycin biosynthesis_Homo sapiens_hsa005240.60996182
123Chemokine signaling pathway_Homo sapiens_hsa040620.59878936
124Retinol metabolism_Homo sapiens_hsa008300.58539650
125Legionellosis_Homo sapiens_hsa051340.57733469
126GABAergic synapse_Homo sapiens_hsa047270.56591118
127Hepatitis B_Homo sapiens_hsa051610.56116014
128Selenocompound metabolism_Homo sapiens_hsa004500.55384850
129Autoimmune thyroid disease_Homo sapiens_hsa053200.54905146
130Glycine, serine and threonine metabolism_Homo sapiens_hsa002600.54666106
131Notch signaling pathway_Homo sapiens_hsa043300.54592595
132Arachidonic acid metabolism_Homo sapiens_hsa005900.54543185
133cAMP signaling pathway_Homo sapiens_hsa040240.53923328
134Wnt signaling pathway_Homo sapiens_hsa043100.53781964
135Calcium signaling pathway_Homo sapiens_hsa040200.53605593
136Antigen processing and presentation_Homo sapiens_hsa046120.53479275
137Influenza A_Homo sapiens_hsa051640.53408555
138Metabolic pathways_Homo sapiens_hsa011000.53262228
139One carbon pool by folate_Homo sapiens_hsa006700.53202185
140Jak-STAT signaling pathway_Homo sapiens_hsa046300.52207628
141Dopaminergic synapse_Homo sapiens_hsa047280.51818777
142Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010400.51485043
143Inositol phosphate metabolism_Homo sapiens_hsa005620.51002219
144Renin secretion_Homo sapiens_hsa049240.50840646
145Renin-angiotensin system_Homo sapiens_hsa046140.50650443
146Graft-versus-host disease_Homo sapiens_hsa053320.49806228
147Glycerophospholipid metabolism_Homo sapiens_hsa005640.49225032
148Arginine and proline metabolism_Homo sapiens_hsa003300.49221948
149Steroid hormone biosynthesis_Homo sapiens_hsa001400.49004866
150Peroxisome_Homo sapiens_hsa041460.48948421
151Leishmaniasis_Homo sapiens_hsa051400.48929217
152Bladder cancer_Homo sapiens_hsa052190.48689815
153Tuberculosis_Homo sapiens_hsa051520.47292007
154Amyotrophic lateral sclerosis (ALS)_Homo sapiens_hsa050140.47200746
155Cytokine-cytokine receptor interaction_Homo sapiens_hsa040600.44231893
156Melanoma_Homo sapiens_hsa052180.43843314
157Apoptosis_Homo sapiens_hsa042100.42554618
158Oocyte meiosis_Homo sapiens_hsa041140.42445548
159Viral carcinogenesis_Homo sapiens_hsa052030.42361021
160Ovarian steroidogenesis_Homo sapiens_hsa049130.41961603
161Prostate cancer_Homo sapiens_hsa052150.41837326
162Toll-like receptor signaling pathway_Homo sapiens_hsa046200.41222222
163Phagosome_Homo sapiens_hsa041450.40198369
164Toxoplasmosis_Homo sapiens_hsa051450.40078643
165Progesterone-mediated oocyte maturation_Homo sapiens_hsa049140.39697199
166p53 signaling pathway_Homo sapiens_hsa041150.38687544
167Carbohydrate digestion and absorption_Homo sapiens_hsa049730.36799706
168Long-term depression_Homo sapiens_hsa047300.36149607
169Starch and sucrose metabolism_Homo sapiens_hsa005000.34965261
170T cell receptor signaling pathway_Homo sapiens_hsa046600.34742444

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