HOOK1

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: This gene encodes a member of the hook family of coiled-coil proteins, which bind to microtubules and organelles through their N- and C-terminal domains, respectively. The encoded protein localizes to discrete punctuate subcellular structures, and interacts with several members of the Rab GTPase family involved in endocytosis. It is thought to link endocytic membrane trafficking to the microtubule cytoskeleton. Several alternatively spliced transcript variants have been identified, but the full-length nature of some of these variants has not been determined. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1sperm motility (GO:0030317)4.95918112
2intestinal cholesterol absorption (GO:0030299)4.82776931
3L-phenylalanine catabolic process (GO:0006559)4.77754344
4erythrose 4-phosphate/phosphoenolpyruvate family amino acid catabolic process (GO:1902222)4.77754344
5erythrose 4-phosphate/phosphoenolpyruvate family amino acid metabolic process (GO:1902221)4.45845321
6L-phenylalanine metabolic process (GO:0006558)4.45845321
7fusion of sperm to egg plasma membrane (GO:0007342)4.32331793
8bundle of His cell to Purkinje myocyte communication (GO:0086069)4.31839327
9cell wall macromolecule metabolic process (GO:0044036)4.26172423
10cell wall macromolecule catabolic process (GO:0016998)4.26172423
11intestinal absorption (GO:0050892)4.17026582
12urea cycle (GO:0000050)4.13324259
13urea metabolic process (GO:0019627)4.13324259
14acrosome assembly (GO:0001675)3.96622945
15cilium or flagellum-dependent cell motility (GO:0001539)3.95409236
16aromatic amino acid family catabolic process (GO:0009074)3.80222687
17cysteine metabolic process (GO:0006534)3.70853433
18single strand break repair (GO:0000012)3.70012283
19cellular glucuronidation (GO:0052695)3.69813970
20nitrogen cycle metabolic process (GO:0071941)3.66092459
21L-alpha-amino acid transmembrane transport (GO:1902475)3.62600312
22sperm-egg recognition (GO:0035036)3.60572811
23homocysteine metabolic process (GO:0050667)3.60328097
24glucuronate metabolic process (GO:0019585)3.56814676
25uronic acid metabolic process (GO:0006063)3.56814676
26COPI coating of Golgi vesicle (GO:0048205)3.54431451
27Golgi transport vesicle coating (GO:0048200)3.54431451
28regulation of bile acid biosynthetic process (GO:0070857)3.51921794
29macroautophagy (GO:0016236)3.50013504
30regulation of centriole replication (GO:0046599)3.49319362
31epithelial cilium movement (GO:0003351)3.42920124
32* spermatid development (GO:0007286)3.41795861
33desmosome organization (GO:0002934)3.41464405
34plasma membrane fusion (GO:0045026)3.37730474
35epithelial cell fate commitment (GO:0072148)3.33704200
36sulfur amino acid catabolic process (GO:0000098)3.33208777
37drug transmembrane transport (GO:0006855)3.32318589
38triglyceride-rich lipoprotein particle remodeling (GO:0034370)3.31933984
39Golgi to endosome transport (GO:0006895)3.29055993
40lysine metabolic process (GO:0006553)3.28199446
41lysine catabolic process (GO:0006554)3.28199446
42male meiosis (GO:0007140)3.28135927
43binding of sperm to zona pellucida (GO:0007339)3.27626797
44multicellular organism reproduction (GO:0032504)3.26634578
45acrosome reaction (GO:0007340)3.26247462
46piRNA metabolic process (GO:0034587)3.23812213
47alpha-linolenic acid metabolic process (GO:0036109)3.21448660
48cell-cell recognition (GO:0009988)3.20737085
49drug catabolic process (GO:0042737)3.20607920
50protein targeting to Golgi (GO:0000042)3.19874117
51COPII vesicle coating (GO:0048208)3.19633087
52kynurenine metabolic process (GO:0070189)3.16538305
53bile acid biosynthetic process (GO:0006699)3.15361476
54sperm capacitation (GO:0048240)3.14394046
55regulation of cholesterol homeostasis (GO:2000188)3.14056549
56bile acid and bile salt transport (GO:0015721)3.13795822
57synaptonemal complex assembly (GO:0007130)3.13365978
58serine family amino acid catabolic process (GO:0009071)3.12932811
59bile acid metabolic process (GO:0008206)3.12749573
60positive regulation of glycolytic process (GO:0045821)3.12443308
61high-density lipoprotein particle remodeling (GO:0034375)3.12349131
62glutamate metabolic process (GO:0006536)3.11477937
63synaptonemal complex organization (GO:0070193)3.10588341
64positive regulation of calcium ion-dependent exocytosis (GO:0045956)3.10234776
65lactate metabolic process (GO:0006089)3.08054160
66establishment of protein localization to Golgi (GO:0072600)3.05209637
67epithelial cilium movement involved in determination of left/right asymmetry (GO:0060287)3.01028949
68indole-containing compound catabolic process (GO:0042436)3.00351325
69indolalkylamine catabolic process (GO:0046218)3.00351325
70tryptophan catabolic process (GO:0006569)3.00351325
71tryptophan metabolic process (GO:0006568)2.99492919
72reproduction (GO:0000003)2.97360982
73protein localization to Golgi apparatus (GO:0034067)2.97083001
74endocrine pancreas development (GO:0031018)2.96216863
75axonemal dynein complex assembly (GO:0070286)2.93443157
76cilium movement (GO:0003341)2.93438467
77regulation of type B pancreatic cell apoptotic process (GO:2000674)2.92030506
78regulation of cilium movement (GO:0003352)2.91950174
79chromosome condensation (GO:0030261)2.91218649
80acylglycerol homeostasis (GO:0055090)2.89293480
81triglyceride homeostasis (GO:0070328)2.89293480
82DNA packaging (GO:0006323)2.89189780
83calcium ion-dependent exocytosis (GO:0017156)2.88983730
84cellular ketone body metabolic process (GO:0046950)2.87991123
85ketone body metabolic process (GO:1902224)2.87959391
86negative regulation of cholesterol transport (GO:0032375)2.87720109
87negative regulation of sterol transport (GO:0032372)2.87720109
88embryonic retina morphogenesis in camera-type eye (GO:0060059)2.86080413
89dicarboxylic acid biosynthetic process (GO:0043650)2.85796811
90epoxygenase P450 pathway (GO:0019373)2.85631615
91sphingomyelin metabolic process (GO:0006684)2.83887678
92phenylpropanoid metabolic process (GO:0009698)2.83761730
93reverse cholesterol transport (GO:0043691)2.83607473
94organic cation transport (GO:0015695)2.82600032
95alpha-amino acid catabolic process (GO:1901606)2.78722526
96motile cilium assembly (GO:0044458)2.78635128
97glyoxylate metabolic process (GO:0046487)2.77775835
98nodal signaling pathway (GO:0038092)2.77711283
99axoneme assembly (GO:0035082)2.76991413
100rRNA methylation (GO:0031167)2.76775802
101tyrosine metabolic process (GO:0006570)2.76644009
102positive regulation of gluconeogenesis (GO:0045722)2.76269412
103amino-acid betaine metabolic process (GO:0006577)2.75991871
104aspartate family amino acid catabolic process (GO:0009068)2.75214410
105fatty acid beta-oxidation using acyl-CoA oxidase (GO:0033540)2.74652795
106cellular modified amino acid catabolic process (GO:0042219)2.74562893
107maintenance of protein localization in endoplasmic reticulum (GO:0035437)2.74121409
108aromatic amino acid family metabolic process (GO:0009072)2.73333482
109ethanol oxidation (GO:0006069)2.73265200
110regulation of triglyceride catabolic process (GO:0010896)2.72823765
111retrograde transport, vesicle recycling within Golgi (GO:0000301)2.71206570
112nuclear pore complex assembly (GO:0051292)2.70709483
113complement activation, alternative pathway (GO:0006957)2.69132367
114negative regulation of digestive system process (GO:0060457)2.68466463
115flavonoid metabolic process (GO:0009812)2.68398863
116hormone catabolic process (GO:0042447)2.67992249
117cellular amino acid catabolic process (GO:0009063)2.67073490
118regulation of short-term neuronal synaptic plasticity (GO:0048172)2.66855893
119tight junction assembly (GO:0070830)2.64624366
120membrane repolarization during cardiac muscle cell action potential (GO:0086013)2.64357816
121regulation of water loss via skin (GO:0033561)2.63348763
122regulation of protein activation cascade (GO:2000257)2.62623159
123multicellular organismal water homeostasis (GO:0050891)2.62395158
124ethanol metabolic process (GO:0006067)2.61129893
125glutamine family amino acid biosynthetic process (GO:0009084)2.60636457
126exogenous drug catabolic process (GO:0042738)2.60134607
127calcium-independent cell-cell adhesion via plasma membrane cell-adhesion molecules (GO:0016338)2.57765647
128ribosome assembly (GO:0042255)2.56838474
129phosphatidylethanolamine biosynthetic process (GO:0006646)2.56584918
130glandular epithelial cell differentiation (GO:0002067)2.55532319
131positive regulation of histone H3-K4 methylation (GO:0051571)2.54916267
132intestinal epithelial cell development (GO:0060576)2.54676724
133establishment of skin barrier (GO:0061436)2.53080718
134protein-lipid complex remodeling (GO:0034368)2.52602673
135macromolecular complex remodeling (GO:0034367)2.52602673
136plasma lipoprotein particle remodeling (GO:0034369)2.52602673
137negative regulation of neurotransmitter secretion (GO:0046929)2.50520285
138negative regulation of hormone metabolic process (GO:0032351)2.47922443
139centriole replication (GO:0007099)2.47148950
140regulation of acrosome reaction (GO:0060046)2.46483529
141columnar/cuboidal epithelial cell development (GO:0002066)2.46186162
142mitotic sister chromatid cohesion (GO:0007064)2.45282605
143nephron tubule morphogenesis (GO:0072078)2.45243214
144nephron epithelium morphogenesis (GO:0072088)2.45243214
145response to phenylpropanoid (GO:0080184)2.45062598
146water homeostasis (GO:0030104)2.44672966
147centriole assembly (GO:0098534)2.40257276
148histone H3-K9 demethylation (GO:0033169)2.39716976
149transcytosis (GO:0045056)2.38025020
150nuclear pore organization (GO:0006999)2.37976394
151phosphatidylethanolamine metabolic process (GO:0046337)2.36491306
152insulin secretion (GO:0030073)2.36021111
153regulation of cell-cell adhesion mediated by cadherin (GO:2000047)2.35476643
154magnesium ion transport (GO:0015693)2.34298999
155vitamin transmembrane transport (GO:0035461)2.33988602
156Leydig cell differentiation (GO:0033327)2.33203938
157keratinization (GO:0031424)2.32636878
158regulation of endoplasmic reticulum stress-induced intrinsic apoptotic signaling pathway (GO:19022352.31376709
159male gamete generation (GO:0048232)2.30965127
160spermatogenesis (GO:0007283)2.30810729
161epithelial cell maturation (GO:0002070)2.29439407
162prostate epithelial cord arborization involved in prostate glandular acinus morphogenesis (GO:0060522.28202144
163coenzyme catabolic process (GO:0009109)2.26983630
164microtubule depolymerization (GO:0007019)2.26422665
165cellular zinc ion homeostasis (GO:0006882)2.26066463
166intra-Golgi vesicle-mediated transport (GO:0006891)2.25284359

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1ESR1_17901129_ChIP-ChIP_LIVER_Mouse4.84206048
2EZH2_22144423_ChIP-Seq_EOC_Human3.67282949
3RXR_22158963_ChIP-Seq_LIVER_Mouse3.66071359
4* LXR_22158963_ChIP-Seq_LIVER_Mouse3.21619142
5* PPARA_22158963_ChIP-Seq_LIVER_Mouse3.20456957
6PRDM16_22522345_ChIP-ChIP_PALATE_MESENCHYMAL_Mouse3.04576884
7FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse3.02314492
8GLI1_17442700_ChIP-ChIP_MESCs_Mouse2.84940006
9BCL11B_21912641_ChIP-Seq_STHDH_STRIUM_Mouse2.81304575
10MYBL1_21750041_ChIP-ChIP_SPERMATOCYTES_Mouse2.64192423
11EGR1_23403033_ChIP-Seq_LIVER_Mouse2.60067014
12FOXO1_23066095_ChIP-Seq_LIVER_Mouse2.57997748
13ZFP322A_24550733_ChIP-Seq_MESCs_Mouse2.48909368
14NR1I2_20693526_ChIP-Seq_LIVER_Mouse2.02874849
15REST_21632747_ChIP-Seq_MESCs_Mouse1.98784735
16FOXA1_27197147_Chip-Seq_ENDOMETRIOID-ADENOCARCINOMA_Human1.89030292
17ZNF274_21170338_ChIP-Seq_K562_Hela1.87629449
18CDX2_19796622_ChIP-Seq_MESCs_Mouse1.75115518
19P300_19829295_ChIP-Seq_ESCs_Human1.70759147
20AR_21909140_ChIP-Seq_LNCAP_Human1.69128489
21BMI1_23680149_ChIP-Seq_NPCS_Mouse1.66531473
22FOXO3_23340844_ChIP-Seq_DLD1_Human1.61508181
23ER_23166858_ChIP-Seq_MCF-7_Human1.60885430
24NR4A2_19515692_ChIP-ChIP_MN9D_Mouse1.60597960
25SMARCD1_25818293_ChIP-Seq_ESCs_Mouse1.59283073
26TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.56315842
27ARNT_22903824_ChIP-Seq_MCF-7_Human1.54303148
28CDX2_20551321_ChIP-Seq_CACO-2_Human1.52953301
29SOX2_27498859_Chip-Seq_STOMACH_Mouse1.51192688
30TAF15_26573619_Chip-Seq_HEK293_Human1.51077756
31* FOXA2_19822575_ChIP-Seq_HepG2_Human1.50548801
32CEBPA_23403033_ChIP-Seq_LIVER_Mouse1.49487417
33GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.47467880
34* FOXA1_25552417_ChIP-Seq_VCAP_Human1.46914095
35CTBP2_25329375_ChIP-Seq_LNCAP_Human1.45587531
36IGF1R_20145208_ChIP-Seq_DFB_Human1.45320113
37SMAD3_21741376_ChIP-Seq_EPCs_Human1.44525840
38* KDM5B_21448134_ChIP-Seq_MESCs_Mouse1.43719649
39AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human1.43299378
40GATA6_25053715_ChIP-Seq_YYC3_Human1.40460671
41* RCOR1_19997604_ChIP-ChIP_NEURONS_Mouse1.40166248
42REST_18959480_ChIP-ChIP_MESCs_Mouse1.39811807
43* FOXA1_26743006_Chip-Seq_LNCaP-abl_Human1.38509230
44RCOR2_21632747_ChIP-Seq_MESCs_Mouse1.37061589
45DROSHA_22980978_ChIP-Seq_HELA_Human1.36316694
46TOP2B_26459242_ChIP-Seq_MCF-7_Human1.36108547
47RARB_27405468_Chip-Seq_BRAIN_Mouse1.35989126
48CBP_20019798_ChIP-Seq_JUKART_Human1.34920349
49IRF4_20064451_ChIP-Seq_CD4+T_Mouse1.34920349
50MYCN_21190229_ChIP-Seq_SHEP-21N_Human1.34305724
51SMAD4_19686287_ChIP-ChIP_HaCaT_Human1.33766884
52MEIS1_26253404_ChIP-Seq_OPTIC_CUPS_Mouse1.33457261
53BCAT_22108803_ChIP-Seq_LS180_Human1.31761689
54STAT3_23295773_ChIP-Seq_U87_Human1.30058639
55AHR_22903824_ChIP-Seq_MCF-7_Human1.30009343
56EWS_26573619_Chip-Seq_HEK293_Human1.29863054
57* TCF4_18268006_ChIP-ChIP_LS174T_Human1.28563338
58PRDM5_23873026_ChIP-Seq_MEFs_Mouse1.28495126
59* CREM_20920259_ChIP-Seq_GC1-SPG_Mouse1.26431520
60CTBP1_25329375_ChIP-Seq_LNCAP_Human1.25913882
61CEBPB_23403033_ChIP-Seq_LIVER_Mouse1.24672592
62* FOXA1_26769127_Chip-Seq_PDAC-Cell_line_Human1.24266157
63HNF4A_19761587_ChIP-ChIP_CACO-2_Human1.24166554
64GATA3_24758297_ChIP-Seq_MCF-7_Human1.23649849
65SMAD4_21799915_ChIP-Seq_A2780_Human1.23568095
66* UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human1.23076958
67P300_18555785_Chip-Seq_ESCs_Mouse1.22427343
68* TCF4_22108803_ChIP-Seq_LS180_Human1.20158093
69* PCGF4_22325352_ChIP-Seq_293T-Rex_Human1.19421530
70TAL1_21186366_ChIP-Seq_BM-HSCs_Mouse1.19397467
71VDR_22108803_ChIP-Seq_LS180_Human1.18550900
72TCF4_23295773_ChIP-Seq_U87_Human1.18270144
73KLF5_20875108_ChIP-Seq_MESCs_Mouse1.18049864
74NR3C1_21868756_ChIP-Seq_MCF10A_Human1.17175336
75HNF4A_19822575_ChIP-Seq_HepG2_Human1.17098584
76* RBPJ_21746931_ChIP-Seq_IB4_Human1.17045078
77E2F1_18555785_Chip-Seq_ESCs_Mouse1.16423772
78SUZ12_18555785_Chip-Seq_ESCs_Mouse1.15812872
79* HNFA_21074721_ChIP-Seq_CACO-2_Human1.15365050
80ERA_27197147_Chip-Seq_ENDOMETRIOID-ADENOCARCINOMA_Human1.14978291
81CEBPD_23245923_ChIP-Seq_MEFs_Mouse1.14724372
82* ETV1_20927104_ChIP-Seq_GIST48_Human1.14720409
83* NFYB_21822215_ChIP-Seq_K562_Human1.14433355
84* PHF8_20622853_ChIP-Seq_HELA_Human1.14123327
85SOX2_18555785_Chip-Seq_ESCs_Mouse1.13837693
86TCFCP2L1_18555785_Chip-Seq_ESCs_Mouse1.13260908
87ESR1_20079471_ChIP-ChIP_T-47D_Human1.13014265
88POU3F2_20337985_ChIP-ChIP_501MEL_Human1.12708577
89CDX2_21402776_ChIP-Seq_INTESTINAL-VILLUS_Mouse1.12372495
90ZNF217_24962896_ChIP-Seq_MCF-7_Human1.12126301
91* TBL1_22424771_ChIP-Seq_293T_Human1.11747053
92GBX2_23144817_ChIP-Seq_PC3_Human1.11469954
93SALL1_21062744_ChIP-ChIP_HESCs_Human1.11146635
94ZNF652_21678463_ChIP-ChIP_ZR75-1_Human1.10069393
95FOXA1_27270436_Chip-Seq_PROSTATE_Human1.09981707
96FOXA1_25329375_ChIP-Seq_VCAP_Human1.09981707
97HTT_18923047_ChIP-ChIP_STHdh_Human1.09721042
98* TP63_23658742_ChIP-Seq_EP156T_Human1.09502887
99RUNX2_22187159_ChIP-Seq_PCA_Human1.09187734
100RCOR3_21632747_ChIP-Seq_MESCs_Mouse1.08963340
101STAT3_18555785_Chip-Seq_ESCs_Mouse1.08663318
102* CBX2_22325352_ChIP-Seq_293T-Rex_Human1.07477692
103WDR5_24793694_ChIP-Seq_LNCAP_Human1.07385031
104FOXA1_21572438_ChIP-Seq_LNCaP_Human1.06927633
105FLI1_21867929_ChIP-Seq_TH2_Mouse1.06293573
106FLI1_27457419_Chip-Seq_LIVER_Mouse1.05589512
107KDM2B_26808549_Chip-Seq_REH_Human1.05159000
108STAT1_17558387_ChIP-Seq_HELA_Human1.04529144
109CDX2_22108803_ChIP-Seq_LS180_Human1.04132763
110TCF7L2_21901280_ChIP-Seq_H4IIE_Rat1.03584599
111NANOG_18555785_Chip-Seq_ESCs_Mouse1.03379808
112GATA2_21186366_ChIP-Seq_BM-HSCs_Mouse1.02269810
113ELK4_26923725_Chip-Seq_MESODERM_Mouse1.01674803
114AR_21915096_ChIP-Seq_LNCaP-1F5_Human1.01512049
115KAP1_22055183_ChIP-Seq_ESCs_Mouse1.01150334
116SMAD2/3_21741376_ChIP-Seq_EPCs_Human1.01102168
117TEAD4_22529382_ChIP-Seq_TROPHECTODERM_Mouse0.99202564
118PIAS1_25552417_ChIP-Seq_VCAP_Human0.98284412
119EZH2_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse0.97679921
120TAL1_26923725_Chip-Seq_HPCs_Mouse0.97054780
121FUS_26573619_Chip-Seq_HEK293_Human0.96318273
122SOX2_21211035_ChIP-Seq_LN229_Gbm0.95900941
123STAT6_21828071_ChIP-Seq_BEAS2B_Human0.91882578
124EWS-FLI1_20517297_ChIP-Seq_SK-N-MC_Human0.91185663
125AR_19668381_ChIP-Seq_PC3_Human0.90329688
126BACH1_22875853_ChIP-PCR_HELA_AND_SCP4_Human0.90136497
127SMAD4_21741376_ChIP-Seq_EPCs_Human0.89799053
128AR_25329375_ChIP-Seq_VCAP_Human0.89546141
129NFE2_27457419_Chip-Seq_LIVER_Mouse0.89411636
130FOXM1_26456572_ChIP-Seq_MCF-7_Human0.89257284
131FOXA1_21915096_ChIP-Seq_LNCaP-1F5_Human0.88991419
132CEBPB_26923725_Chip-Seq_HEMOGENIC-ENDOTHELIUM_Mouse0.88703933
133* POU5F1_26923725_Chip-Seq_MESODERM_Mouse0.88389952
134* TEAD4_26923725_Chip-Seq_HEMANGIOBLAST_Mouse0.88389952
135ZFP57_27257070_Chip-Seq_ESCs_Mouse0.87838269
136SUZ12_27294783_Chip-Seq_NPCs_Mouse0.87835332
137PCGF2_27294783_Chip-Seq_ESCs_Mouse0.87168552
138GATA4_25053715_ChIP-Seq_YYC3_Human0.86233745
139LUZP1_20508642_ChIP-Seq_ESCs_Mouse0.86007805
140CBP_21632823_ChIP-Seq_H3396_Human0.85846968
141MEIS1_26923725_Chip-Seq_HEMOGENIC-ENDOTHELIUM_Mouse0.84973204
142EBF1_22473956_ChIP-Seq_BONE_MARROW_Mouse0.84810952
143YAP1_20516196_ChIP-Seq_MESCs_Mouse0.84520750
144OCT4_18555785_Chip-Seq_ESCs_Mouse0.83876248
145KLF4_25985364_ChIP-Seq_ATHEROSCLEROSIS_LESION_Mouse0.83409123
146REST_19997604_ChIP-ChIP_NEURONS_Mouse0.83239734
147FLI1_26923725_Chip-Seq_MACROPHAGESS_Mouse0.83031742
148P53_22387025_ChIP-Seq_ESCs_Mouse0.83031005
149CMYC_18555785_Chip-Seq_ESCs_Mouse0.82583943

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0002139_abnormal_hepatobiliary_system5.33947116
2MP0005365_abnormal_bile_salt4.85106753
3MP0005360_urolithiasis4.74925523
4MP0005085_abnormal_gallbladder_physiolo4.67364650
5MP0005410_abnormal_fertilization3.72019968
6MP0001666_abnormal_nutrient_absorption3.29613388
7MP0003252_abnormal_bile_duct3.15711926
8MP0010234_abnormal_vibrissa_follicle3.10391834
9MP0008875_abnormal_xenobiotic_pharmacok2.95367614
10MP0005083_abnormal_biliary_tract2.52376789
11MP0003868_abnormal_feces_composition2.42847556
12MP0008057_abnormal_DNA_replication2.29624083
13MP0004264_abnormal_extraembryonic_tissu2.20394590
14MP0010329_abnormal_lipoprotein_level2.16770751
15MP0004043_abnormal_pH_regulation2.14280851
16MP0009780_abnormal_chondrocyte_physiolo1.94990415
17MP0010678_abnormal_skin_adnexa1.94601539
18MP0003283_abnormal_digestive_organ1.91342868
19MP0003941_abnormal_skin_development1.89544339
20MP0002909_abnormal_adrenal_gland1.85682173
21MP0010352_gastrointestinal_tract_polyps1.83396059
22MP0003195_calcinosis1.82693830
23MP0002163_abnormal_gland_morphology1.81876124
24MP0000566_synostosis1.81592447
25* MP0003698_abnormal_male_reproductive1.78160843
26MP0003806_abnormal_nucleotide_metabolis1.77801633
27MP0005551_abnormal_eye_electrophysiolog1.77372832
28MP0005220_abnormal_exocrine_pancreas1.77094553
29MP0004019_abnormal_vitamin_homeostasis1.71651623
30MP0003122_maternal_imprinting1.68964391
31MP0006072_abnormal_retinal_apoptosis1.68853059
32MP0002693_abnormal_pancreas_physiology1.67676687
33MP0002822_catalepsy1.65947932
34MP0001944_abnormal_pancreas_morphology1.62963000
35MP0003718_maternal_effect1.61855850
36* MP0001929_abnormal_gametogenesis1.60309375
37MP0004782_abnormal_surfactant_physiolog1.59192927
38MP0003878_abnormal_ear_physiology1.57239149
39MP0005377_hearing/vestibular/ear_phenot1.57239149
40MP0004270_analgesia1.55054972
41MP0008877_abnormal_DNA_methylation1.53880592
42MP0005332_abnormal_amino_acid1.51001997
43MP0005187_abnormal_penis_morphology1.44069265
44MP0004859_abnormal_synaptic_plasticity1.39680469
45MP0001765_abnormal_ion_homeostasis1.39569260
46MP0002138_abnormal_hepatobiliary_system1.36993901
47MP0002078_abnormal_glucose_homeostasis1.35095377
48MP0002118_abnormal_lipid_homeostasis1.34901637
49MP0001764_abnormal_homeostasis1.30613115
50MP0003890_abnormal_embryonic-extraembry1.30360217
51MP0001188_hyperpigmentation1.30236511
52MP0004957_abnormal_blastocyst_morpholog1.28804905
53MP0008961_abnormal_basal_metabolism1.25841492
54MP0000383_abnormal_hair_follicle1.17204423
55MP0005253_abnormal_eye_physiology1.16142642
56MP0000609_abnormal_liver_physiology1.16017070
57MP0000462_abnormal_digestive_system1.15875892
58MP0002876_abnormal_thyroid_physiology1.13703423
59MP0003693_abnormal_embryo_hatching1.12424220
60MP0003635_abnormal_synaptic_transmissio1.11851474
61MP0005636_abnormal_mineral_homeostasis1.10129247
62MP0003787_abnormal_imprinting1.08433521
63MP0002160_abnormal_reproductive_system1.08375799
64MP0002928_abnormal_bile_duct1.07845355
65MP0003183_abnormal_peptide_metabolism1.05887229
66MP0005645_abnormal_hypothalamus_physiol1.02457761
67MP0003121_genomic_imprinting1.02408496
68MP0005646_abnormal_pituitary_gland1.02068362
69MP0003011_delayed_dark_adaptation1.00701197
70* MP0002161_abnormal_fertility/fecundity1.00677726
71MP0005084_abnormal_gallbladder_morpholo0.97873372
72MP0003953_abnormal_hormone_level0.96780596
73MP0009643_abnormal_urine_homeostasis0.95867339
74MP0000427_abnormal_hair_cycle0.93572852
75MP0005395_other_phenotype0.92843418
76MP0001664_abnormal_digestion0.92791525
77MP0005448_abnormal_energy_balance0.92363428
78MP0001485_abnormal_pinna_reflex0.91904551
79MP0001145_abnormal_male_reproductive0.91487799
80MP0002653_abnormal_ependyma_morphology0.91457477
81MP0002063_abnormal_learning/memory/cond0.91029688
82MP0005535_abnormal_body_temperature0.90311587
83MP0003879_abnormal_hair_cell0.90121440
84MP0000653_abnormal_sex_gland0.89201992
85MP0010386_abnormal_urinary_bladder0.87876745
86MP0001756_abnormal_urination0.87668639
87MP0005319_abnormal_enzyme/_coenzyme0.87370937
88MP0002210_abnormal_sex_determination0.87366244
89MP0002234_abnormal_pharynx_morphology0.87216863
90MP0001502_abnormal_circadian_rhythm0.86285761
91MP0002098_abnormal_vibrissa_morphology0.84692410
92MP0001984_abnormal_olfaction0.84477993
93MP0001501_abnormal_sleep_pattern0.84467276
94MP0002229_neurodegeneration0.83757661
95MP0003119_abnormal_digestive_system0.82846732
96MP0005501_abnormal_skin_physiology0.82371262
97MP0003123_paternal_imprinting0.82076801
98MP0002837_dystrophic_cardiac_calcinosis0.81182411
99MP0005379_endocrine/exocrine_gland_phen0.80986361
100MP0000579_abnormal_nail_morphology0.80262173
101MP0009745_abnormal_behavioral_response0.79911747
102MP0005647_abnormal_sex_gland0.78284744
103MP0003300_gastrointestinal_ulcer0.77892458
104MP0003937_abnormal_limbs/digits/tail_de0.77657434
105MP0008872_abnormal_physiological_respon0.76759401
106MP0002254_reproductive_system_inflammat0.76240203
107MP0002877_abnormal_melanocyte_morpholog0.75196524
108MP0003656_abnormal_erythrocyte_physiolo0.74103513
109MP0000678_abnormal_parathyroid_gland0.74080724
110MP0009672_abnormal_birth_weight0.73602958
111MP0000013_abnormal_adipose_tissue0.72665047
112MP0002572_abnormal_emotion/affect_behav0.72382763
113MP0004133_heterotaxia0.71288117
114MP0000613_abnormal_salivary_gland0.68646805
115MP0003329_amyloid_beta_deposits0.68293207
116MP0009697_abnormal_copulation0.66588424
117MP0002734_abnormal_mechanical_nocicepti0.65949942
118MP0000631_abnormal_neuroendocrine_gland0.65296483
119MP0002069_abnormal_eating/drinking_beha0.65012706
120MP0002009_preneoplasia0.64655665
121MP0002084_abnormal_developmental_patter0.64362395
122MP0000470_abnormal_stomach_morphology0.62473447
123MP0002277_abnormal_respiratory_mucosa0.62315459
124MP0001881_abnormal_mammary_gland0.61990737
125MP0002796_impaired_skin_barrier0.61471043
126MP0001216_abnormal_epidermal_layer0.61216888
127MP0002233_abnormal_nose_morphology0.61146801
128MP0002557_abnormal_social/conspecific_i0.59538041
129MP0005423_abnormal_somatic_nervous0.58412500
130MP0004885_abnormal_endolymph0.58229276
131MP0009046_muscle_twitch0.58142144
132MP0005386_behavior/neurological_phenoty0.56034284
133MP0004924_abnormal_behavior0.56034284
134MP0005584_abnormal_enzyme/coenzyme_acti0.56020069
135MP0001324_abnormal_eye_pigmentation0.55804794
136MP0000537_abnormal_urethra_morphology0.54617714
137MP0004233_abnormal_muscle_weight0.53803205
138MP0001486_abnormal_startle_reflex0.53678992
139MP0008004_abnormal_stomach_pH0.53337748

Predicted human phenotypes

RankGene SetZ-score
1Intrahepatic cholestasis (HP:0001406)4.77337068
2Respiratory insufficiency due to defective ciliary clearance (HP:0200073)4.31989412
3Abnormality of aromatic amino acid family metabolism (HP:0004338)4.25215224
4Dynein arm defect of respiratory motile cilia (HP:0012255)4.24670692
5Absent/shortened dynein arms (HP:0200106)4.24670692
6Abnormality of monocarboxylic acid metabolism (HP:0010996)4.07595474
7Hyperinsulinemic hypoglycemia (HP:0000825)3.94606086
8Hypobetalipoproteinemia (HP:0003563)3.94071449
9Conjugated hyperbilirubinemia (HP:0002908)3.62155604
10Chronic bronchitis (HP:0004469)3.56664577
11Hypoglycemic seizures (HP:0002173)3.53727486
12Unilateral renal agenesis (HP:0000122)3.46296591
13Hypoglycemic coma (HP:0001325)3.43376022
14Ketosis (HP:0001946)3.35158679
15Ketoacidosis (HP:0001993)3.33256564
16Deep venous thrombosis (HP:0002625)3.20464702
17Gout (HP:0001997)3.20064804
18Fat malabsorption (HP:0002630)3.19171666
19Abnormality of the lower motor neuron (HP:0002366)3.19004733
20Abnormal respiratory motile cilium physiology (HP:0012261)3.12625557
21Right ventricular cardiomyopathy (HP:0011663)3.02483515
22Symptomatic seizures (HP:0011145)2.99182201
23Prolonged partial thromboplastin time (HP:0003645)2.85977928
24Infertility (HP:0000789)2.84977456
25Abnormality of the intrinsic pathway (HP:0010989)2.80397260
26Epidermoid cyst (HP:0200040)2.77203722
27Hyperglycemia (HP:0003074)2.76211102
28Hyperglycinemia (HP:0002154)2.75058342
29Abnormality of vitamin metabolism (HP:0100508)2.70186958
30Xanthomatosis (HP:0000991)2.69855421
31Central scotoma (HP:0000603)2.67390585
32Hyperphosphatemia (HP:0002905)2.66605206
33Hypolipoproteinemia (HP:0010981)2.64795524
34Late onset (HP:0003584)2.64225947
35Abnormality of the common coagulation pathway (HP:0010990)2.60827162
36Abnormal respiratory motile cilium morphology (HP:0005938)2.60705430
37Abnormal respiratory epithelium morphology (HP:0012253)2.60705430
38Rhinitis (HP:0012384)2.59912257
39Male infertility (HP:0003251)2.58360644
40Abnormality of vitamin B metabolism (HP:0004340)2.57148580
41Abnormality of glutamine family amino acid metabolism (HP:0010902)2.52777503
42Vascular calcification (HP:0004934)2.52474376
43Double outlet right ventricle (HP:0001719)2.48842349
44Congenital malformation of the right heart (HP:0011723)2.48842349
45Lip pit (HP:0100267)2.48292014
46Abnormality of chloride homeostasis (HP:0011422)2.45106894
47Hepatoblastoma (HP:0002884)2.43289331
48Abnormality of purine metabolism (HP:0004352)2.42797343
49Glycosuria (HP:0003076)2.42788217
50Abnormality of urine glucose concentration (HP:0011016)2.42788217
51Elevated circulating parathyroid hormone (PTH) level (HP:0003165)2.42529449
52Abnormality of sulfur amino acid metabolism (HP:0004339)2.42036694
53Hypothermia (HP:0002045)2.40125161
54Acanthocytosis (HP:0001927)2.39007085
55Tubulointerstitial nephritis (HP:0001970)2.38046877
56Proximal tubulopathy (HP:0000114)2.37352577
57Abnormal ciliary motility (HP:0012262)2.37272532
58Hyperammonemia (HP:0001987)2.36787376
59Abnormality of endocrine pancreas physiology (HP:0012093)2.35753958
60Abnormality of the pancreatic islet cells (HP:0006476)2.35753958
61Hyperglycinuria (HP:0003108)2.33403192
62Type II diabetes mellitus (HP:0005978)2.29868644
63Abnormality of renin-angiotensin system (HP:0000847)2.29483437
64Visual hallucinations (HP:0002367)2.28662744
65Posterior subcapsular cataract (HP:0007787)2.28635282
66Complement deficiency (HP:0004431)2.27135052
67Bony spicule pigmentary retinopathy (HP:0007737)2.26224519
68Abnormality of macular pigmentation (HP:0008002)2.21731109
69Ventricular fibrillation (HP:0001663)2.21659990
70Megaloblastic anemia (HP:0001889)2.21079996
71Hypomagnesemia (HP:0002917)2.17376994
72Abnormal biliary tract morphology (HP:0012440)2.14656366
73Abnormality of nucleobase metabolism (HP:0010932)2.13435948
74Abnormality of the level of lipoprotein cholesterol (HP:0010979)2.12988295
75Increased purine levels (HP:0004368)2.12614269
76Hyperuricemia (HP:0002149)2.12614269
77Dyschromatopsia (HP:0007641)2.11752959
78Osteomalacia (HP:0002749)2.10930127
79Pigmentary retinal degeneration (HP:0001146)2.10093870
80Malnutrition (HP:0004395)2.09607462
81Chorioretinal atrophy (HP:0000533)2.09280503
82Abnormality of aspartate family amino acid metabolism (HP:0010899)2.08804754
83Abnormality of serine family amino acid metabolism (HP:0010894)2.08789806
84Abnormality of glycine metabolism (HP:0010895)2.08789806
85Increased circulating renin level (HP:0000848)2.08433462
86Decreased central vision (HP:0007663)2.08362261
87Septate vagina (HP:0001153)2.05645116
88Retinal atrophy (HP:0001105)2.00391316
89Congenital stationary night blindness (HP:0007642)1.99857158
90Hyperphosphaturia (HP:0003109)1.99102398
91Abnormality of potassium homeostasis (HP:0011042)1.98981230
92Chronic hepatic failure (HP:0100626)1.97225011
93Abnormal gallbladder physiology (HP:0012438)1.96591056
94Cholecystitis (HP:0001082)1.96591056
95Hypercholesterolemia (HP:0003124)1.96213338
96Insulin-resistant diabetes mellitus (HP:0000831)1.95068360
97Hyperbilirubinemia (HP:0002904)1.94264427
98Abnormality of the vitamin B12 metabolism (HP:0004341)1.92424144
99Hypoalphalipoproteinemia (HP:0003233)1.91860115
100Spontaneous abortion (HP:0005268)1.91058633
101Hyperkalemia (HP:0002153)1.89817466
102Skin nodule (HP:0200036)1.88688339
103Papillary thyroid carcinoma (HP:0002895)1.88682060
104Cardiovascular calcification (HP:0011915)1.88630450
105Hyponatremia (HP:0002902)1.88530198
106Abnormality of the dental root (HP:0006486)1.87601139
107Taurodontia (HP:0000679)1.87601139
108Abnormality of permanent molar morphology (HP:0011071)1.87601139
109Status epilepticus (HP:0002133)1.87000392
110EEG with generalized epileptiform discharges (HP:0011198)1.86960475
111Hyperlipoproteinemia (HP:0010980)1.86000140
112Hyperaldosteronism (HP:0000859)1.85756846
113Epileptiform EEG discharges (HP:0011182)1.85209708
114Limb hypertonia (HP:0002509)1.82228847
115Hypsarrhythmia (HP:0002521)1.80921456
116Resting tremor (HP:0002322)1.80732688
117Impaired smooth pursuit (HP:0007772)1.80567926
118Decreased circulating renin level (HP:0003351)1.80409218
119Pancreatic islet-cell hyperplasia (HP:0004510)1.79858141
120Hyperactive renin-angiotensin system (HP:0000841)1.79553084
121Biliary tract neoplasm (HP:0100574)1.79469794
122Abnormality of renal excretion (HP:0011036)1.79317012
123Steatorrhea (HP:0002570)1.77412805
124Abnormality of calcium-phosphate metabolism (HP:0100530)1.76582433
125Absent eyebrow (HP:0002223)1.76532156
126Abnormal pancreas size (HP:0012094)1.76485390
127Abnormality of ocular smooth pursuit (HP:0000617)1.74953503
128Menstrual irregularities (HP:0000858)1.73268158
129Cone-rod dystrophy (HP:0000548)1.73164660
130Abnormality of methionine metabolism (HP:0010901)1.73152823
131Subcapsular cataract (HP:0000523)1.72563108
132Abnormality of the dental pulp (HP:0006479)1.72409437
133Abnormality of magnesium homeostasis (HP:0004921)1.72405078
134Irritability (HP:0000737)1.71417617
135Abnormality of small intestinal villus morphology (HP:0011472)1.70568142
136Villous atrophy (HP:0011473)1.70568142
137Abnormal rod and cone electroretinograms (HP:0008323)1.69883006
138Tubulointerstitial abnormality (HP:0001969)1.69645310
139Bronchiectasis (HP:0002110)1.68823812
140Abnormal urine phosphate concentration (HP:0012599)1.68520272
141Volvulus (HP:0002580)1.68508256
142Neoplasm of the adrenal cortex (HP:0100641)1.66432860
143Facial shape deformation (HP:0011334)1.66221855
144Potter facies (HP:0002009)1.66221855
145Thyroid carcinoma (HP:0002890)1.65566188
146Curly hair (HP:0002212)1.65538746
147Urethral obstruction (HP:0000796)1.64636664
148Abnormality of the nasal septum (HP:0000419)1.63953985
149Woolly hair (HP:0002224)1.63919810
150Breast carcinoma (HP:0003002)1.63835589

Predicted kinase interactions (KEA)

RankGene SetZ-score
1PDK34.37149722
2PDK44.37149722
3FRK3.96813434
4INSRR3.10714734
5PRKD33.08335323
6MST42.87689662
7NTRK32.86159098
8PLK42.82785208
9TAOK32.65965097
10EIF2AK32.59738226
11PDK22.45843622
12MAP3K22.44309335
13FGFR22.38337847
14LATS12.37537086
15MAP3K42.29153782
16MAP3K92.05938665
17PASK2.01332030
18LMTK21.98433632
19BCKDK1.79836594
20STK241.78631014
21TNIK1.76775513
22MKNK21.76594273
23WNK41.73519248
24PNCK1.73172196
25ACVR1B1.66342429
26STK381.61215426
27NLK1.54123230
28MAP2K41.53524244
29FGFR31.47811426
30OXSR11.47795540
31DAPK21.47090261
32WNK31.46050297
33MAP3K121.45604373
34SCYL21.44076772
35EPHA41.34942192
36AKT31.34910399
37ICK1.28116892
38CASK1.21660526
39RIPK11.19892351
40STK31.19319125
41TAF11.14692387
42KSR21.11752227
43PKN21.09110885
44PTK61.07747605
45TESK11.06959654
46CAMKK11.01571782
47NEK61.00815723
48MAPK150.99960504
49FGFR10.99880991
50CDK120.98116606
51DYRK1B0.97421779
52MAP2K70.96987943
53MAP4K20.93580498
54MARK10.91094119
55MET0.87855460
56MKNK10.87274259
57FLT30.85564792
58ERBB30.84767960
59RET0.83414815
60STK38L0.82580543
61CAMK1G0.80146702
62TSSK60.80018656
63ZAK0.79608122
64PRKAA10.79531328
65PDK10.79085494
66PLK30.77888435
67PLK20.77694174
68MAP3K10.76939854
69ERBB40.76077059
70PRKCE0.74989489
71MAP2K60.74354877
72KSR10.73482078
73SIK10.72592224
74ERN10.71112493
75TTK0.70678303
76TRPM70.70608127
77STK390.70469906
78FER0.70037671
79HIPK20.68513580
80CAMK1D0.67800972
81PIK3CA0.67666667
82PRKAA20.67349094
83NEK10.67313851
84MAP3K70.66292360
85PLK10.65289496
86PAK60.65265186
87MST1R0.65023329
88CDC42BPA0.62919336
89NME10.61976931
90CSNK1G10.60703368
91SGK20.60551103
92ERBB20.60417495
93TYRO30.59688627
94RPS6KB10.58701336
95CSNK1E0.58412790
96CDC70.57387884
97EEF2K0.57284928
98MINK10.57135743
99STK110.55622935
100SGK30.55005507
101DAPK10.54568360
102PRKCG0.54513005
103EIF2AK20.53443939
104PTK20.53110455
105RPS6KB20.52463896
106NTRK20.51386407
107NEK20.49498497
108GRK10.49071264
109EPHA20.48958867
110MAP3K100.48898618
111BRSK20.48561342
112LATS20.48430992
113RPS6KA30.47953295
114BRD40.47887047
115ATM0.47871888
116CDK50.47531730
117CHUK0.46939919
118PAK30.46273093
119PRKDC0.45605620
120PRKG20.45499822
121PRKCZ0.44803568
122PDPK10.43644811
123BRSK10.43560881
124PRKCI0.43114303
125WNK10.42635655
126MAP2K20.42213273
127CHEK10.41642250
128FGFR40.41419956
129PINK10.41394921
130CDK70.41278210
131MTOR0.41098157
132TAOK10.40005318
133SGK4940.39297954
134SGK2230.39297954
135AKT20.38698951
136SGK10.38588614
137CSNK1D0.38454019
138MAP3K60.38079226
139DYRK1A0.37972499
140NUAK10.37963209
141CDK10.37912915
142ALK0.37196420
143CDK20.37002938
144CSNK1A10.36891594
145GSK3B0.36510004
146CDK30.35028271
147PHKG20.34749679

Predicted pathways (KEGG)

RankGene SetZ-score
1Maturity onset diabetes of the young_Homo sapiens_hsa049504.13154035
2Nitrogen metabolism_Homo sapiens_hsa009103.72594086
3Primary bile acid biosynthesis_Homo sapiens_hsa001202.74384143
4Vitamin B6 metabolism_Homo sapiens_hsa007502.68634875
5Ascorbate and aldarate metabolism_Homo sapiens_hsa000532.45474632
6Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004002.44369531
7Arginine biosynthesis_Homo sapiens_hsa002202.38150607
8Fat digestion and absorption_Homo sapiens_hsa049752.23596305
9Tryptophan metabolism_Homo sapiens_hsa003802.05966752
10Selenocompound metabolism_Homo sapiens_hsa004502.01746765
11Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049641.96573416
12Sulfur metabolism_Homo sapiens_hsa009201.89321336
13Fatty acid degradation_Homo sapiens_hsa000711.81475631
14Bile secretion_Homo sapiens_hsa049761.78551728
15Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002501.78478525
16Propanoate metabolism_Homo sapiens_hsa006401.77000653
17Pyruvate metabolism_Homo sapiens_hsa006201.75515932
18Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006301.74153163
19Butanoate metabolism_Homo sapiens_hsa006501.69017194
20Insulin secretion_Homo sapiens_hsa049111.65816671
21Valine, leucine and isoleucine degradation_Homo sapiens_hsa002801.61544388
22Carbohydrate digestion and absorption_Homo sapiens_hsa049731.54583266
23Pancreatic secretion_Homo sapiens_hsa049721.50069000
24Glycolysis / Gluconeogenesis_Homo sapiens_hsa000101.45819042
25Glycine, serine and threonine metabolism_Homo sapiens_hsa002601.36307683
26Phototransduction_Homo sapiens_hsa047441.35712871
27Sphingolipid metabolism_Homo sapiens_hsa006001.34267552
28Protein processing in endoplasmic reticulum_Homo sapiens_hsa041411.33356806
29Glycerolipid metabolism_Homo sapiens_hsa005611.31868999
30ABC transporters_Homo sapiens_hsa020101.29293843
31Drug metabolism - cytochrome P450_Homo sapiens_hsa009821.23223725
32Glucagon signaling pathway_Homo sapiens_hsa049221.23025039
33Butirosin and neomycin biosynthesis_Homo sapiens_hsa005241.22168726
34Pentose and glucuronate interconversions_Homo sapiens_hsa000401.19966669
35Type II diabetes mellitus_Homo sapiens_hsa049301.18871488
36Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006011.17659974
37Histidine metabolism_Homo sapiens_hsa003401.16992371
38Renin-angiotensin system_Homo sapiens_hsa046141.16926688
39Starch and sucrose metabolism_Homo sapiens_hsa005001.16309230
40Amphetamine addiction_Homo sapiens_hsa050311.15811537
41Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa049611.14997225
42Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010401.10240535
43PPAR signaling pathway_Homo sapiens_hsa033201.09987328
44Biosynthesis of amino acids_Homo sapiens_hsa012301.09913924
45Lysine degradation_Homo sapiens_hsa003101.09111205
46Complement and coagulation cascades_Homo sapiens_hsa046101.07849897
47Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008601.06156150
48Cyanoamino acid metabolism_Homo sapiens_hsa004601.05696205
49Fatty acid metabolism_Homo sapiens_hsa012121.05264084
50Cysteine and methionine metabolism_Homo sapiens_hsa002701.04227247
51Long-term potentiation_Homo sapiens_hsa047201.00711377
52Carbon metabolism_Homo sapiens_hsa012000.97359795
53Protein export_Homo sapiens_hsa030600.96563693
54Tight junction_Homo sapiens_hsa045300.95562242
55Peroxisome_Homo sapiens_hsa041460.93024789
56Chemical carcinogenesis_Homo sapiens_hsa052040.90631226
57Ether lipid metabolism_Homo sapiens_hsa005650.90297434
58Citrate cycle (TCA cycle)_Homo sapiens_hsa000200.89679735
59Phenylalanine metabolism_Homo sapiens_hsa003600.89328969
60Nicotine addiction_Homo sapiens_hsa050330.89137603
61Pantothenate and CoA biosynthesis_Homo sapiens_hsa007700.88978282
62beta-Alanine metabolism_Homo sapiens_hsa004100.88598403
63Thyroid hormone synthesis_Homo sapiens_hsa049180.86334065
64Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009800.84550898
65Drug metabolism - other enzymes_Homo sapiens_hsa009830.83553245
66Synaptic vesicle cycle_Homo sapiens_hsa047210.83168031
67Fructose and mannose metabolism_Homo sapiens_hsa000510.80677494
68Folate biosynthesis_Homo sapiens_hsa007900.80190248
69One carbon pool by folate_Homo sapiens_hsa006700.80178269
70GABAergic synapse_Homo sapiens_hsa047270.79166039
71Taste transduction_Homo sapiens_hsa047420.77691720
72Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa049600.77374084
73Circadian entrainment_Homo sapiens_hsa047130.77014665
74Fatty acid elongation_Homo sapiens_hsa000620.76735721
75Vitamin digestion and absorption_Homo sapiens_hsa049770.76227422
76Retinol metabolism_Homo sapiens_hsa008300.75972017
77RNA transport_Homo sapiens_hsa030130.74701648
78Non-homologous end-joining_Homo sapiens_hsa034500.73861009
79Cocaine addiction_Homo sapiens_hsa050300.72590602
802-Oxocarboxylic acid metabolism_Homo sapiens_hsa012100.70566783
81Dopaminergic synapse_Homo sapiens_hsa047280.70102858
82Thyroid cancer_Homo sapiens_hsa052160.69767511
83alpha-Linolenic acid metabolism_Homo sapiens_hsa005920.68431756
84Glutamatergic synapse_Homo sapiens_hsa047240.68072975
85Fatty acid biosynthesis_Homo sapiens_hsa000610.67905193
86Aldosterone synthesis and secretion_Homo sapiens_hsa049250.66847643
87Terpenoid backbone biosynthesis_Homo sapiens_hsa009000.66717057
88Serotonergic synapse_Homo sapiens_hsa047260.66655634
89Protein digestion and absorption_Homo sapiens_hsa049740.64743150
90Steroid hormone biosynthesis_Homo sapiens_hsa001400.64645655
91Retrograde endocannabinoid signaling_Homo sapiens_hsa047230.64154770
92Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030080.63796918
93Taurine and hypotaurine metabolism_Homo sapiens_hsa004300.63445754
94Tyrosine metabolism_Homo sapiens_hsa003500.63160382
95Linoleic acid metabolism_Homo sapiens_hsa005910.60408868
96Arachidonic acid metabolism_Homo sapiens_hsa005900.58884186
97Metabolic pathways_Homo sapiens_hsa011000.58629185
98Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005120.58538531
99Caffeine metabolism_Homo sapiens_hsa002320.58046811
100Mineral absorption_Homo sapiens_hsa049780.57934067
101Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001300.56816636
102Circadian rhythm_Homo sapiens_hsa047100.56489189
103Renin secretion_Homo sapiens_hsa049240.55146996
104Synthesis and degradation of ketone bodies_Homo sapiens_hsa000720.54218098
105N-Glycan biosynthesis_Homo sapiens_hsa005100.53868784
106Phosphatidylinositol signaling system_Homo sapiens_hsa040700.53858665
107Insulin resistance_Homo sapiens_hsa049310.53625411
108Salivary secretion_Homo sapiens_hsa049700.53487585
109Gastric acid secretion_Homo sapiens_hsa049710.53439606
110Glycerophospholipid metabolism_Homo sapiens_hsa005640.52327369
111Oocyte meiosis_Homo sapiens_hsa041140.49183513
112Galactose metabolism_Homo sapiens_hsa000520.46987781
113Dorso-ventral axis formation_Homo sapiens_hsa043200.45997776
114Pentose phosphate pathway_Homo sapiens_hsa000300.45524782
115mRNA surveillance pathway_Homo sapiens_hsa030150.45387560
116Glutathione metabolism_Homo sapiens_hsa004800.44901077
117Cholinergic synapse_Homo sapiens_hsa047250.43459801
118Estrogen signaling pathway_Homo sapiens_hsa049150.42797961
119Vasopressin-regulated water reabsorption_Homo sapiens_hsa049620.42068660
120Morphine addiction_Homo sapiens_hsa050320.41654648
121Arginine and proline metabolism_Homo sapiens_hsa003300.41202636
122Sulfur relay system_Homo sapiens_hsa041220.40357415
123Inositol phosphate metabolism_Homo sapiens_hsa005620.39739589
124Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005630.38695670
125AMPK signaling pathway_Homo sapiens_hsa041520.37241798
126Long-term depression_Homo sapiens_hsa047300.36059294

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