HOOK2

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: Hook proteins are cytosolic coiled-coil proteins that contain conserved N-terminal domains, which attach to microtubules, and more divergent C-terminal domains, which mediate binding to organelles. The Drosophila Hook protein is a component of the endocytic compartment. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1DNA deamination (GO:0045006)4.77188019
2regulation of nuclear cell cycle DNA replication (GO:0033262)4.21605167
3regulation of mitochondrial translation (GO:0070129)4.18142239
4positive regulation of fatty acid beta-oxidation (GO:0032000)4.09005362
5positive regulation of fatty acid oxidation (GO:0046321)4.01238270
6rRNA modification (GO:0000154)3.90623952
7desmosome organization (GO:0002934)3.87962708
8fatty acid transmembrane transport (GO:1902001)3.71441384
9tRNA methylation (GO:0030488)3.64946094
10proteasome assembly (GO:0043248)3.64815496
11regulation of sequestering of triglyceride (GO:0010889)3.60192685
12white fat cell differentiation (GO:0050872)3.58467673
13carnitine shuttle (GO:0006853)3.49831423
14ribosomal large subunit biogenesis (GO:0042273)3.49475713
15regulation of triglyceride catabolic process (GO:0010896)3.48859868
16protein K6-linked ubiquitination (GO:0085020)3.48809723
17maturation of SSU-rRNA (GO:0030490)3.48111723
18amino-acid betaine transport (GO:0015838)3.46856442
19carnitine transport (GO:0015879)3.46856442
20termination of RNA polymerase III transcription (GO:0006386)3.45848903
21transcription elongation from RNA polymerase III promoter (GO:0006385)3.45848903
22carnitine transmembrane transport (GO:1902603)3.41433469
23ribosomal small subunit biogenesis (GO:0042274)3.38528141
24regulation of fatty acid oxidation (GO:0046320)3.36781777
25vitamin transmembrane transport (GO:0035461)3.35418580
26biotin metabolic process (GO:0006768)3.31079184
27ribonucleoprotein complex biogenesis (GO:0022613)3.27363594
28transcytosis (GO:0045056)3.25924025
29regulation of helicase activity (GO:0051095)3.24162890
30ribosome biogenesis (GO:0042254)3.22134893
31bundle of His cell to Purkinje myocyte communication (GO:0086069)3.19078637
32positive regulation of protein kinase C signaling (GO:0090037)3.16503647
33NADH metabolic process (GO:0006734)3.10916122
34rRNA methylation (GO:0031167)3.10797844
35quaternary ammonium group transport (GO:0015697)3.09588894
36regulation of fatty acid beta-oxidation (GO:0031998)3.08877450
37microtubule depolymerization (GO:0007019)3.07785849
38axonemal dynein complex assembly (GO:0070286)3.07687859
39interferon-gamma secretion (GO:0072643)3.06196550
40proline metabolic process (GO:0006560)3.04901920
41purine nucleobase biosynthetic process (GO:0009113)3.04389898
42ribosome assembly (GO:0042255)3.03454724
43cilium or flagellum-dependent cell motility (GO:0001539)3.02810969
44nucleobase biosynthetic process (GO:0046112)3.02089019
45purine ribonucleoside bisphosphate metabolic process (GO:0034035)2.98437487
463-phosphoadenosine 5-phosphosulfate metabolic process (GO:0050427)2.98437487
47positive regulation of triglyceride metabolic process (GO:0090208)2.97280060
48chromatin remodeling at centromere (GO:0031055)2.96147327
49kinetochore assembly (GO:0051382)2.95999644
50flavonoid metabolic process (GO:0009812)2.94459718
51transcription from RNA polymerase I promoter (GO:0006360)2.94194627
52mitotic metaphase plate congression (GO:0007080)2.94075786
53positive regulation of triglyceride biosynthetic process (GO:0010867)2.92941177
54replicative senescence (GO:0090399)2.92589754
55telomere maintenance via semi-conservative replication (GO:0032201)2.91193988
56spliceosomal snRNP assembly (GO:0000387)2.89482853
57termination of RNA polymerase I transcription (GO:0006363)2.89310714
58deoxyribonucleoside triphosphate metabolic process (GO:0009200)2.89267645
59glutathione biosynthetic process (GO:0006750)2.88769881
60transcription elongation from RNA polymerase I promoter (GO:0006362)2.88140054
61maturation of 5.8S rRNA (GO:0000460)2.87609892
62rRNA processing (GO:0006364)2.87587753
63sulfate transmembrane transport (GO:1902358)2.87303407
64regulation of telomere maintenance via telomerase (GO:0032210)2.84299722
65folic acid metabolic process (GO:0046655)2.83790186
66mitochondrial DNA replication (GO:0006264)2.83628441
67CENP-A containing nucleosome assembly (GO:0034080)2.83366705
68centriole assembly (GO:0098534)2.83125048
69rRNA metabolic process (GO:0016072)2.82477835
70regulation of triglyceride biosynthetic process (GO:0010866)2.81520902
717-methylguanosine mRNA capping (GO:0006370)2.81371323
72intestinal epithelial cell development (GO:0060576)2.81276913
73DNA replication initiation (GO:0006270)2.80226612
74DNA damage response, detection of DNA damage (GO:0042769)2.78891920
75piRNA metabolic process (GO:0034587)2.77989757
76RNA methylation (GO:0001510)2.77781944
77negative regulation of intrinsic apoptotic signaling pathway by p53 class mediator (GO:1902254)2.77454299
78transcription-coupled nucleotide-excision repair (GO:0006283)2.76962553
79DNA replication checkpoint (GO:0000076)2.76565590
80striated muscle atrophy (GO:0014891)2.75314041
81centriole replication (GO:0007099)2.75220227
82water-soluble vitamin biosynthetic process (GO:0042364)2.75102719
83auditory receptor cell differentiation (GO:0042491)2.75097057
84nonribosomal peptide biosynthetic process (GO:0019184)2.74892506
85diacylglycerol metabolic process (GO:0046339)2.74858003
86cellular ketone body metabolic process (GO:0046950)2.74713184
87RNA capping (GO:0036260)2.74466251
887-methylguanosine RNA capping (GO:0009452)2.74466251
89tRNA modification (GO:0006400)2.73205285
90DNA-dependent DNA replication (GO:0006261)2.72236841
91triglyceride catabolic process (GO:0019433)2.71115658
92single strand break repair (GO:0000012)2.70900926
93exonucleolytic nuclear-transcribed mRNA catabolic process involved in deadenylation-dependent decay 2.70894731
94regulation of gene silencing by RNA (GO:0060966)2.70281031
95regulation of posttranscriptional gene silencing (GO:0060147)2.70281031
96regulation of gene silencing by miRNA (GO:0060964)2.70281031
97negative regulation of phosphatidylinositol 3-kinase signaling (GO:0014067)2.69756110
98positive regulation of lipid catabolic process (GO:0050996)2.69550785
99keratinocyte development (GO:0003334)2.69338089
100DNA methylation involved in gamete generation (GO:0043046)2.69018432
101histone H4-K12 acetylation (GO:0043983)2.68137541
102DNA strand elongation involved in DNA replication (GO:0006271)2.67504658
103regulation of double-strand break repair via homologous recombination (GO:0010569)2.67207731
104establishment of integrated proviral latency (GO:0075713)2.67199614
105telomere maintenance via recombination (GO:0000722)2.66379611
106cellular component biogenesis (GO:0044085)2.65040771
107positive regulation of fatty acid metabolic process (GO:0045923)2.64880389
108acetyl-CoA metabolic process (GO:0006084)2.64530825
109pseudouridine synthesis (GO:0001522)2.64110715
110cell wall macromolecule catabolic process (GO:0016998)2.63930299
111cell wall macromolecule metabolic process (GO:0044036)2.63930299
112nuclear-transcribed mRNA catabolic process, exonucleolytic (GO:0000291)2.63232978
113regulation of triglyceride metabolic process (GO:0090207)2.62357288
114ribosomal small subunit assembly (GO:0000028)2.61991812
115DNA integration (GO:0015074)2.61244281
116viral transcription (GO:0019083)2.61129878
117reciprocal DNA recombination (GO:0035825)2.59817970
118reciprocal meiotic recombination (GO:0007131)2.59817970
119quinone biosynthetic process (GO:1901663)2.59226523
120regulation of cell proliferation involved in kidney development (GO:1901722)2.59189219
121sperm-egg recognition (GO:0035036)2.58202375
122telomere maintenance via telomere lengthening (GO:0010833)2.57428312
123protein-cofactor linkage (GO:0018065)2.56370718
124GTP biosynthetic process (GO:0006183)2.56324335
125nephron tubule morphogenesis (GO:0072078)2.56214262
126nephron epithelium morphogenesis (GO:0072088)2.56214262
127DNA strand elongation (GO:0022616)2.55456272
128translational termination (GO:0006415)2.54924758
129ethanol metabolic process (GO:0006067)2.54686724
130deoxyribonucleotide biosynthetic process (GO:0009263)2.54490472
131neutral lipid catabolic process (GO:0046461)2.54156275
132acylglycerol catabolic process (GO:0046464)2.54156275
133synaptonemal complex assembly (GO:0007130)2.54054135
134RNA splicing, via endonucleolytic cleavage and ligation (GO:0000394)2.53924135
135tRNA splicing, via endonucleolytic cleavage and ligation (GO:0006388)2.53924135
136intestinal absorption (GO:0050892)2.53267583
137histone exchange (GO:0043486)2.52847388
138binding of sperm to zona pellucida (GO:0007339)2.52736779
139calcium-independent cell-cell adhesion via plasma membrane cell-adhesion molecules (GO:0016338)2.52719511
140blastocyst development (GO:0001824)2.51845878
141response to stimulus involved in regulation of muscle adaptation (GO:0014874)2.51488731
142positive regulation of digestive system process (GO:0060456)2.50950381
143somatic hypermutation of immunoglobulin genes (GO:0016446)2.50801369
144somatic diversification of immune receptors via somatic mutation (GO:0002566)2.50801369
145terpenoid biosynthetic process (GO:0016114)2.50781512
146negative regulation of androgen receptor signaling pathway (GO:0060766)2.50708204
147negative regulation of DNA-dependent DNA replication (GO:2000104)2.49898730
148translation (GO:0006412)2.49663986
149positive regulation of glycogen biosynthetic process (GO:0045725)2.49210031
150intestinal cholesterol absorption (GO:0030299)2.48329614
151metaphase plate congression (GO:0051310)2.47906053
152oligosaccharide catabolic process (GO:0009313)2.46364803
153toxin metabolic process (GO:0009404)2.45267943
154ethanol oxidation (GO:0006069)2.43666454
155acylglycerol homeostasis (GO:0055090)2.43358261
156triglyceride homeostasis (GO:0070328)2.43358261
157glycerolipid catabolic process (GO:0046503)2.43186671
158alkaloid metabolic process (GO:0009820)2.43090873
159transepithelial transport (GO:0070633)2.41940150
160response to food (GO:0032094)2.41618977
161phenol-containing compound catabolic process (GO:0019336)2.40457701
162skeletal muscle adaptation (GO:0043501)2.39735066
163glycerol metabolic process (GO:0006071)2.39050895
164phosphatidylglycerol biosynthetic process (GO:0006655)2.38475819
165behavioral response to nicotine (GO:0035095)2.37682269
166alditol metabolic process (GO:0019400)2.37468455
167regulation of vascular endothelial growth factor signaling pathway (GO:1900746)2.37460299
168fatty acid beta-oxidation (GO:0006635)2.37272225
169monocarboxylic acid catabolic process (GO:0072329)2.36066643
170fatty acid catabolic process (GO:0009062)2.34633097
171sulfur amino acid catabolic process (GO:0000098)2.34432300
172glandular epithelial cell differentiation (GO:0002067)2.34420618
173sulfation (GO:0051923)2.33909694
174peptide biosynthetic process (GO:0043043)2.32820526
175fucose catabolic process (GO:0019317)2.32133039
176L-fucose metabolic process (GO:0042354)2.32133039
177L-fucose catabolic process (GO:0042355)2.32133039
178primary alcohol catabolic process (GO:0034310)2.31751667
179kynurenine metabolic process (GO:0070189)2.31446808
1802-oxoglutarate metabolic process (GO:0006103)2.31343817
181multicellular organismal water homeostasis (GO:0050891)2.30795184
182axoneme assembly (GO:0035082)2.29949578
183ubiquinone biosynthetic process (GO:0006744)2.29688594
184sulfate transport (GO:0008272)2.27623583
185brown fat cell differentiation (GO:0050873)2.26540632
186muscle atrophy (GO:0014889)2.26533346
187drug catabolic process (GO:0042737)2.26053596
188regulation of digestive system process (GO:0044058)2.25913205
189ketone body metabolic process (GO:1902224)2.25775620
190L-ascorbic acid metabolic process (GO:0019852)2.25635925
191glutathione derivative biosynthetic process (GO:1901687)2.25301271
192glutathione derivative metabolic process (GO:1901685)2.25301271
193cardiac right ventricle morphogenesis (GO:0003215)2.24725110
194branched-chain amino acid catabolic process (GO:0009083)2.24710452
195ubiquinone metabolic process (GO:0006743)2.23472863
196phosphatidylserine acyl-chain remodeling (GO:0036150)2.23222182
197sulfur compound transport (GO:0072348)2.23163070
198positive regulation of glycogen metabolic process (GO:0070875)2.22369046
199epoxygenase P450 pathway (GO:0019373)2.21811621
200purine nucleoside bisphosphate metabolic process (GO:0034032)2.21654913

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1E2F7_22180533_ChIP-Seq_HELA_Human4.57629828
2PPARG_19300518_ChIP-PET_3T3-L1_Mouse3.83365382
3* MYC_18555785_ChIP-Seq_MESCs_Mouse3.64506310
4KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human3.62985405
5E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse3.52737013
6ESR1_21235772_ChIP-Seq_MCF-7_Human3.36568683
7MYBL1_21750041_ChIP-ChIP_SPERMATOCYTES_Mouse3.22714170
8* JARID1A_20064375_ChIP-Seq_MESCs_Mouse3.11482218
9EST1_17652178_ChIP-ChIP_JURKAT_Human2.94592475
10ESR2_21235772_ChIP-Seq_MCF-7_Human2.93228055
11GABP_17652178_ChIP-ChIP_JURKAT_Human2.93003100
12* MYC_19079543_ChIP-ChIP_MESCs_Mouse2.83943498
13CIITA_18437201_ChIP-ChIP_Raji_B_and_iDC_Human2.68460471
14ETS1_20019798_ChIP-Seq_JURKAT_Human2.67321180
15* MYC_18358816_ChIP-ChIP_MESCs_Mouse2.64025757
16FOXM1_25889361_ChIP-Seq_OE33_AND_U2OS_Human2.53991915
17* MYC_19030024_ChIP-ChIP_MESCs_Mouse2.51131022
18E2F4_17652178_ChIP-ChIP_JURKAT_Human2.32760095
19TP63_17297297_ChIP-ChIP_HaCaT_Human2.31800775
20* NANOG_18555785_ChIP-Seq_MESCs_Mouse2.31442427
21TFAP2C_20629094_ChIP-Seq_MCF-7_Human2.30734727
22CHD1_19587682_ChIP-ChIP_MESCs_Mouse2.27524092
23NOTCH1_17114293_ChIP-ChIP_T-ALL_Human2.22841971
24* POU5F1_18358816_ChIP-ChIP_MESCs_Mouse2.21289416
25SMAD1_18555785_ChIP-Seq_MESCs_Mouse2.17782019
26* KLF2_18264089_ChIP-ChIP_MESCs_Mouse2.15402213
27* KLF5_18264089_ChIP-ChIP_MESCs_Mouse2.15402213
28* KLF4_18264089_ChIP-ChIP_MESCs_Mouse2.15402213
29YY1_21170310_ChIP-Seq_MESCs_Mouse2.15157631
30ESR1_20079471_ChIP-ChIP_T-47D_Human2.14215971
31CTNNB1_20615089_ChIP-ChIP_FETAL_BRAIN_Human2.13036933
32HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human2.08958708
33MYBL2_22936984_ChIP-ChIP_MESCs_Mouse2.07449691
34CREB1_15753290_ChIP-ChIP_HEK293T_Human2.04135135
35* P68_20966046_ChIP-Seq_HELA_Human2.00813363
36PPARA_22158963_ChIP-Seq_LIVER_Mouse2.00434306
37FOXO1_23066095_ChIP-Seq_LIVER_Mouse1.98827799
38* CTCF_27219007_Chip-Seq_Bcells_Human1.98813774
39ELF1_17652178_ChIP-ChIP_JURKAT_Human1.97741860
40E2F1_18555785_ChIP-Seq_MESCs_Mouse1.95642918
41MYCN_21190229_ChIP-Seq_SHEP-21N_Human1.92356018
42TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat1.92004192
43DROSHA_22980978_ChIP-Seq_HELA_Human1.91012882
44* RACK7_27058665_Chip-Seq_MCF-7_Human1.87890998
45HCFC1_20581084_ChIP-Seq_MESCs_Mouse1.87837081
46ESR1_17901129_ChIP-ChIP_LIVER_Mouse1.87559356
47RXR_22158963_ChIP-Seq_LIVER_Mouse1.80717560
48NANOG_18358816_ChIP-ChIP_MESCs_Mouse1.79873072
49* VDR_23849224_ChIP-Seq_CD4+_Human1.79726428
50ERG_21242973_ChIP-ChIP_JURKAT_Human1.79534779
51* NELFA_20434984_ChIP-Seq_ESCs_Mouse1.79286398
52NACC1_18358816_ChIP-ChIP_MESCs_Mouse1.76958750
53POU5F1_18700969_ChIP-ChIP_MESCs_Mouse1.73319650
54ZFP42_18358816_ChIP-ChIP_MESCs_Mouse1.71618860
55FOXM1_23109430_ChIP-Seq_U2OS_Human1.71211998
56DCP1A_22483619_ChIP-Seq_HELA_Human1.67855498
57HIF1A_21447827_ChIP-Seq_MCF-7_Human1.66414106
58XRN2_22483619_ChIP-Seq_HELA_Human1.65522259
59POU5F1_18555785_ChIP-Seq_MESCs_Mouse1.64626216
60SMAD2/3_21741376_ChIP-Seq_ESCs_Human1.64075550
61NR1I2_20693526_ChIP-Seq_LIVER_Mouse1.62317085
62FOXP3_21729870_ChIP-Seq_TREG_Human1.61948406
63* RUNX1_27514584_Chip-Seq_MCF-7_Human1.61426409
64EGR1_23403033_ChIP-Seq_LIVER_Mouse1.60559374
65KAP1_22055183_ChIP-Seq_ESCs_Mouse1.60446691
66SOX2_18555785_ChIP-Seq_MESCs_Mouse1.58751043
67TET1_21451524_ChIP-Seq_MESCs_Mouse1.56860113
68* SRF_21415370_ChIP-Seq_HL-1_Mouse1.55602968
69ESR1_15608294_ChIP-ChIP_MCF-7_Human1.55427848
70PHF8_20622854_ChIP-Seq_HELA_Human1.55207938
71MYCN_18555785_ChIP-Seq_MESCs_Mouse1.55053422
72TCF3_18692474_ChIP-Seq_MEFs_Mouse1.54090699
73SMC4_20622854_ChIP-Seq_HELA_Human1.53426561
74EKLF_21900194_ChIP-Seq_ERYTHROCYTE_Mouse1.52659488
75LXR_22292898_ChIP-Seq_THP-1_Human1.52405175
76SOX9_22984422_ChIP-ChIP_TESTIS_Rat1.51018960
77* E2F1_20622854_ChIP-Seq_HELA_Human1.50724359
78ZNF652_21678463_ChIP-ChIP_ZR75-1_Human1.50687510
79ERA_27197147_Chip-Seq_ENDOMETRIOID-ADENOCARCINOMA_Human1.49723377
80ERA_21632823_ChIP-Seq_H3396_Human1.47596088
81TTF2_22483619_ChIP-Seq_HELA_Human1.46691760
82* STAT3_1855785_ChIP-Seq_MESCs_Mouse1.46460615
83CDX2_20551321_ChIP-Seq_CACO-2_Human1.46414419
84* TP63_22573176_ChIP-Seq_HFKS_Human1.46056026
85ASH2L_23239880_ChIP-Seq_MESCs_Mouse1.44908654
86ZNF263_19887448_ChIP-Seq_K562_Human1.44430370
87P63_26484246_Chip-Seq_KERATINOCYTES_Human1.44107766
88AR_21909140_ChIP-Seq_LNCAP_Human1.43819765
89TCF3_18692474_ChIP-Seq_MESCs_Mouse1.43629801
90TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.42907768
91EZH2_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse1.42472127
92* RARG_19884340_ChIP-ChIP_MEFs_Mouse1.41787892
93* RAD21_21589869_ChIP-Seq_MESCs_Mouse1.41729474
94SALL1_21062744_ChIP-ChIP_HESCs_Human1.40459482
95SOX9_25088423_ChIP-ChIP_EMBRYONIC_GONADS_Mouse1.38108192
96IRF1_19129219_ChIP-ChIP_H3396_Human1.36985882
97* SRY_25088423_ChIP-ChIP_EMBRYONIC_GONADS_Mouse1.36634892
98NANOG_18700969_ChIP-ChIP_MESCs_Mouse1.36613079
99GABP_19822575_ChIP-Seq_HepG2_Human1.34165403
100SRY_22984422_ChIP-ChIP_TESTIS_Rat1.33152051
101LXR_22158963_ChIP-Seq_LIVER_Mouse1.32100783
102EZH2_27294783_Chip-Seq_ESCs_Mouse1.31227409
103PBX_27287812_Chip-Seq_EMBYONIC-LIMB_Mouse1.29001791
104SA1_27219007_Chip-Seq_Bcells_Human1.27877423
105KLF4_19030024_ChIP-ChIP_MESCs_Mouse1.27871993
106BCL6_27268052_Chip-Seq_Bcells_Human1.27750537
107BCOR_27268052_Chip-Seq_Bcells_Human1.27647923
108AHR_22903824_ChIP-Seq_MCF-7_Human1.27593154
109* CREB1_26743006_Chip-Seq_LNCaP_Human1.26642234
110TP63_19390658_ChIP-ChIP_HaCaT_Human1.24949979
111RARB_24833708_ChIP-Seq_LIVER_Mouse1.23720807
112* CREB1_26743006_Chip-Seq_LNCaP-abl_Human1.22332983
113* GATA6_25053715_ChIP-Seq_YYC3_Human1.22133639
114* CEBPA_23403033_ChIP-Seq_LIVER_Mouse1.21345784
115THAP11_20581084_ChIP-Seq_MESCs_Mouse1.19466020
116* STAT5_23275557_ChIP-Seq_MAMMARY-EPITHELIUM_Mouse1.19284375
117NR4A2_19515692_ChIP-ChIP_MN9D_Mouse1.19225059
118P63_20808887_ChIP-Seq_KERATINOCYTES_Human1.18268433
119* CEBPB_23403033_ChIP-Seq_LIVER_Mouse1.17967060
120OCT4_20526341_ChIP-Seq_ESCs_Human1.17830108
121CTCF_20526341_ChIP-Seq_ESCs_Human1.16945863
122GATA1_26923725_Chip-Seq_HPCs_Mouse1.16681418
123* NR0B1_18358816_ChIP-ChIP_MESCs_Mouse1.16373099
124GATA4_25053715_ChIP-Seq_YYC3_Human1.16177345
125SOX2_18692474_ChIP-Seq_MEFs_Mouse1.15272998
126* PDX1_19855005_ChIP-ChIP_MIN6_Mouse1.15266273
127GATA3_24758297_ChIP-Seq_MCF-7_Human1.14990171
128BMI1_19503595_ChIP-Seq_MEFsC_Mouse1.14532481
129P53_21459846_ChIP-Seq_SAOS-2_Human1.13816640
130* DNAJC2_21179169_ChIP-ChIP_NT2_Human1.13753950
131* RAC3_21632823_ChIP-Seq_H3396_Human1.13575255
132MYCN_19997598_ChIP-ChIP_NEUROBLASTOMA_Human1.13316282
133POU5F1_16518401_ChIP-PET_MESCs_Mouse1.12671341
134* KAP1_27257070_Chip-Seq_ESCs_Mouse1.11755076
135ELK1_19687146_ChIP-ChIP_HELA_Human1.10773600
136MYC_18940864_ChIP-ChIP_HL60_Human1.10641372
137TET1_21490601_ChIP-Seq_MESCs_Mouse1.10557825
138SOX2_18358816_ChIP-ChIP_MESCs_Mouse1.10536468
139* KLF4_18358816_ChIP-ChIP_MESCs_Mouse1.10152438
140PCGF2_27294783_Chip-Seq_NPCs_Mouse1.09031752
141* POU5F1_18692474_ChIP-Seq_MESCs_Mouse1.08833197
142NOTCH1_21737748_ChIP-Seq_TLL_Human1.08490747
143NANOG_18692474_ChIP-Seq_MEFs_Mouse1.08371732
144TBP_23326641_ChIP-Seq_C3H10T1-2_Mouse1.07390044
145PCGF2_27294783_Chip-Seq_ESCs_Mouse1.06612261
146SA1_27219007_Chip-Seq_ERYTHROID_Human1.05796922
147SOX2_18692474_ChIP-Seq_MESCs_Mouse1.05525194
148STAT1_20625510_ChIP-Seq_HELA_Human1.05407348
149FOXP1_21924763_ChIP-Seq_HESCs_Human1.04901544
150FOXO3_22982991_ChIP-Seq_MACROPHAGES_Mouse1.04637856
151EBNA2_21746931_ChIP-Seq_IB4-LCL_Human1.03336499
152EZH2_22144423_ChIP-Seq_EOC_Human1.03316042
153ZNF274_21170338_ChIP-Seq_K562_Hela1.02174587
154EBNA1_20929547_Chip-Seq_RAJI-cells_Human1.02067788
155PADI4_21655091_ChIP-ChIP_MCF-7_Human1.01935736
156FOXH1_21741376_ChIP-Seq_ESCs_Human1.01354097
157SOX2_27498859_Chip-Seq_STOMACH_Mouse1.00742738
158KLF5_25053715_ChIP-Seq_YYC3_Human1.00729280
159SUZ12_27294783_Chip-Seq_ESCs_Mouse1.00067612
160THRA_23701648_ChIP-Seq_CEREBELLUM_Mouse0.99571802
161SREBP2_21459322_ChIP-Seq_LIVER_Mouse0.98950817
162HOXB7_26014856_ChIP-Seq_BT474_Human0.98667769
163FLI1_27457419_Chip-Seq_LIVER_Mouse0.98493348
164YY1_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse0.98111143
165STAT6_21828071_ChIP-Seq_BEAS2B_Human0.97993887
166TAF7L_23326641_ChIP-Seq_C3H10T1-2_Mouse0.97039031
167* NANOG_18692474_ChIP-Seq_MESCs_Mouse0.96312311
168OCT4_19829295_ChIP-Seq_ESCs_Human0.96297026
169P300_27268052_Chip-Seq_Bcells_Human0.95901087
170E2F1_21310950_ChIP-Seq_MCF-7_Human0.95879419
171ELF1_20517297_ChIP-Seq_JURKAT_Human0.95614466
172TFAP2A_17053090_ChIP-ChIP_MCF-7_Human0.95386216
173AR_21915096_ChIP-Seq_LNCaP-1F5_Human0.95109081
174TAF2_19829295_ChIP-Seq_ESCs_Human0.94649052
175RBPJ_21746931_ChIP-Seq_IB4-LCL_Human0.93888442
176NEUROD2_26341353_ChIP-Seq_CORTEX_Mouse0.93599145
177GATA3_21867929_ChIP-Seq_CD8_Mouse0.93398622
178RXRA_24833708_ChIP-Seq_LIVER_Mouse0.93116586
179LDB1_21186366_ChIP-Seq_BM-HSCs_Mouse0.92999813
180* CTCF_26484167_Chip-Seq_Bcells_Mouse0.92323787
181* EGR1_20690147_ChIP-Seq_ERYTHROLEUKEMIA_Human0.91821572
182KDM5B_21448134_ChIP-Seq_MESCs_Mouse0.91509978
183RCOR2_21632747_ChIP-Seq_MESCs_Mouse0.91185190
184OCT4_18692474_ChIP-Seq_MEFs_Mouse0.91065118
185SUZ12_20075857_ChIP-Seq_MESCs_Mouse0.90874404
186ETS2_20176728_ChIP-ChIP_TROPHOBLAST_STEM_CELLS_Mouse0.90739266
187KDM5A_27292631_Chip-Seq_BREAST_Human0.90312590
188NFE2_27457419_Chip-Seq_LIVER_Mouse0.89609780
189ELK1_22589737_ChIP-Seq_MCF10A_Human0.88844526
190YY1_22570637_ChIP-Seq_MALME-3M_Human0.88507432
191CNOT3_19339689_ChIP-ChIP_MESCs_Mouse0.87458369
192VDR_22108803_ChIP-Seq_LS180_Human0.86702896

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0003693_abnormal_embryo_hatching3.61241001
2MP0003941_abnormal_skin_development3.51433580
3MP0000566_synostosis3.50963003
4MP0008058_abnormal_DNA_repair3.05294334
5MP0008057_abnormal_DNA_replication2.82441141
6MP0009780_abnormal_chondrocyte_physiolo2.80496310
7MP0003718_maternal_effect2.80267264
8MP0003111_abnormal_nucleus_morphology2.71087575
9MP0003806_abnormal_nucleotide_metabolis2.44848725
10MP0005666_abnormal_adipose_tissue2.41179886
11MP0004264_abnormal_extraembryonic_tissu2.40942658
12MP0006292_abnormal_olfactory_placode2.38609600
13MP0005360_urolithiasis2.34615518
14MP0004019_abnormal_vitamin_homeostasis2.24832534
15MP0004957_abnormal_blastocyst_morpholog2.21268178
16MP0010234_abnormal_vibrissa_follicle2.17775413
17MP0010094_abnormal_chromosome_stability2.17461456
18MP0004145_abnormal_muscle_electrophysio2.11614084
19MP0003786_premature_aging2.11090971
20MP0004130_abnormal_muscle_cell2.08966479
21MP0005410_abnormal_fertilization2.07537023
22MP0010329_abnormal_lipoprotein_level2.05644836
23MP0002277_abnormal_respiratory_mucosa2.04422419
24MP0002909_abnormal_adrenal_gland2.02149574
25MP0000751_myopathy2.00589260
26MP0003077_abnormal_cell_cycle1.95401239
27MP0003878_abnormal_ear_physiology1.93525436
28MP0005377_hearing/vestibular/ear_phenot1.93525436
29MP0005375_adipose_tissue_phenotype1.93356511
30MP0004133_heterotaxia1.93346645
31MP0000383_abnormal_hair_follicle1.80022242
32MP0003646_muscle_fatigue1.77985267
33MP0003136_yellow_coat_color1.72202565
34MP0002132_abnormal_respiratory_system1.70282258
35MP0005083_abnormal_biliary_tract1.69936777
36MP0003011_delayed_dark_adaptation1.68552197
37MP0008877_abnormal_DNA_methylation1.68328102
38MP0002971_abnormal_brown_adipose1.65272276
39MP0002638_abnormal_pupillary_reflex1.64966037
40MP0004185_abnormal_adipocyte_glucose1.64565775
41MP0005085_abnormal_gallbladder_physiolo1.63298197
42MP0009379_abnormal_foot_pigmentation1.60094748
43MP0002139_abnormal_hepatobiliary_system1.59906503
44MP0000003_abnormal_adipose_tissue1.59454639
45MP0001502_abnormal_circadian_rhythm1.58109302
46MP0002098_abnormal_vibrissa_morphology1.56721556
47MP0002210_abnormal_sex_determination1.54913598
48MP0008932_abnormal_embryonic_tissue1.54405585
49MP0001929_abnormal_gametogenesis1.51757798
50MP0000462_abnormal_digestive_system1.50751870
51MP0001666_abnormal_nutrient_absorption1.49862307
52MP0002837_dystrophic_cardiac_calcinosis1.48703713
53MP0003879_abnormal_hair_cell1.48525496
54MP0002653_abnormal_ependyma_morphology1.48486106
55MP0003315_abnormal_perineum_morphology1.47068754
56MP0000678_abnormal_parathyroid_gland1.46911022
57MP0002796_impaired_skin_barrier1.40699262
58MP0000013_abnormal_adipose_tissue1.40034975
59MP0002249_abnormal_larynx_morphology1.39962062
60MP0001145_abnormal_male_reproductive1.37701635
61MP0008872_abnormal_physiological_respon1.36809535
62MP0003787_abnormal_imprinting1.35677452
63MP0005448_abnormal_energy_balance1.34759732
64MP0004381_abnormal_hair_follicle1.34028262
65MP0005395_other_phenotype1.33790664
66MP0010678_abnormal_skin_adnexa1.33733281
67MP0002118_abnormal_lipid_homeostasis1.33375080
68MP0008875_abnormal_xenobiotic_pharmacok1.32740139
69MP0008007_abnormal_cellular_replicative1.32133990
70MP0002254_reproductive_system_inflammat1.31778173
71MP0003698_abnormal_male_reproductive1.29570950
72MP0000613_abnormal_salivary_gland1.28964939
73MP0002160_abnormal_reproductive_system1.27199062
74MP0000579_abnormal_nail_morphology1.25268076
75MP0001501_abnormal_sleep_pattern1.24149436
76MP0005389_reproductive_system_phenotype1.23702490
77MP0000653_abnormal_sex_gland1.22569769
78MP0006138_congestive_heart_failure1.21906149
79MP0004215_abnormal_myocardial_fiber1.20874590
80MP0005670_abnormal_white_adipose1.19434794
81MP0005551_abnormal_eye_electrophysiolog1.19375683
82MP0001986_abnormal_taste_sensitivity1.19127534
83MP0005365_abnormal_bile_salt1.17484392
84MP0004043_abnormal_pH_regulation1.17334207
85MP0002138_abnormal_hepatobiliary_system1.17284991
86MP0001293_anophthalmia1.15963564
87MP0001764_abnormal_homeostasis1.15954653
88MP0005330_cardiomyopathy1.15620160
89MP0001765_abnormal_ion_homeostasis1.15608394
90MP0000427_abnormal_hair_cycle1.14954053
91MP0003186_abnormal_redox_activity1.14694003
92MP0003890_abnormal_embryonic-extraembry1.14576063
93MP0002108_abnormal_muscle_morphology1.13066541
94MP0003137_abnormal_impulse_conducting1.11611087
95MP0008995_early_reproductive_senescence1.11200121
96MP0001664_abnormal_digestion1.10653501
97MP0000490_abnormal_crypts_of1.09841683
98MP0005501_abnormal_skin_physiology1.09242017
99MP0002102_abnormal_ear_morphology1.08906547
100MP0005646_abnormal_pituitary_gland1.08594978
101MP0001188_hyperpigmentation1.08142401
102MP0003119_abnormal_digestive_system1.07006909
103MP0005503_abnormal_tendon_morphology1.05918381
104MP0002078_abnormal_glucose_homeostasis1.04370625
105MP0005332_abnormal_amino_acid1.03831881
106MP0002970_abnormal_white_adipose1.02716156
107MP0005535_abnormal_body_temperature1.02536898
108MP0008789_abnormal_olfactory_epithelium1.02412470
109MP0009840_abnormal_foam_cell1.00213396
110MP0001485_abnormal_pinna_reflex0.99669458
111MP0008775_abnormal_heart_ventricle0.99089021
112MP0000762_abnormal_tongue_morphology0.98689445
113MP0000467_abnormal_esophagus_morphology0.98606778
114MP0003638_abnormal_response/metabolism_0.98103760
115MP0004147_increased_porphyrin_level0.96543269
116MP0005334_abnormal_fat_pad0.96184666
117MP0004858_abnormal_nervous_system0.96161951
118MP0005379_endocrine/exocrine_gland_phen0.94437284
119MP0005367_renal/urinary_system_phenotyp0.93463252
120MP0000516_abnormal_urinary_system0.93463252
121MP0002822_catalepsy0.93011605
122MP0000230_abnormal_systemic_arterial0.92896392
123MP0009643_abnormal_urine_homeostasis0.92702781
124MP0001119_abnormal_female_reproductive0.92525702
125MP0006036_abnormal_mitochondrial_physio0.92369246
126MP0005075_abnormal_melanosome_morpholog0.92004683
127MP0009115_abnormal_fat_cell0.91507407
128MP0003936_abnormal_reproductive_system0.90391014
129MP0003953_abnormal_hormone_level0.89959300
130MP0003195_calcinosis0.88684277
131MP0000750_abnormal_muscle_regeneration0.88196791
132MP0001968_abnormal_touch/_nociception0.87077179
133MP0009697_abnormal_copulation0.86418710
134MP0001346_abnormal_lacrimal_gland0.86048988
135MP0010386_abnormal_urinary_bladder0.84129642
136MP0005499_abnormal_olfactory_system0.82686296
137MP0005394_taste/olfaction_phenotype0.82686296
138MP0000470_abnormal_stomach_morphology0.82152758
139MP0004036_abnormal_muscle_relaxation0.82036222
140MP0004085_abnormal_heartbeat0.81857564
141MP0004084_abnormal_cardiac_muscle0.81850244
142MP0001286_abnormal_eye_development0.81486007
143MP0003937_abnormal_limbs/digits/tail_de0.80420613
144MP0000538_abnormal_urinary_bladder0.80397082
145MP0005452_abnormal_adipose_tissue0.79416252
146MP0005248_abnormal_Harderian_gland0.79106029
147MP0010352_gastrointestinal_tract_polyps0.78695745
148MP0002111_abnormal_tail_morphology0.78449957
149MP0009384_cardiac_valve_regurgitation0.76246262
150MP0002876_abnormal_thyroid_physiology0.75581386
151MP0005174_abnormal_tail_pigmentation0.75345079
152MP0005636_abnormal_mineral_homeostasis0.74946121
153MP0005620_abnormal_muscle_contractility0.74666431
154MP0004782_abnormal_surfactant_physiolog0.74404322
155MP0004087_abnormal_muscle_fiber0.74091358
156MP0005451_abnormal_body_composition0.73548737
157MP0003123_paternal_imprinting0.73153411
158MP0000627_abnormal_mammary_gland0.73147834
159MP0002161_abnormal_fertility/fecundity0.72935403
160MP0001756_abnormal_urination0.72767189
161MP0002085_abnormal_embryonic_tissue0.72341360
162MP0004885_abnormal_endolymph0.72220054
163MP0003938_abnormal_ear_development0.71795038
164MP0005310_abnormal_salivary_gland0.71419841
165MP0001919_abnormal_reproductive_system0.71264097

Predicted human phenotypes

RankGene SetZ-score
1Respiratory insufficiency due to defective ciliary clearance (HP:0200073)4.26452944
2Chromosomal breakage induced by crosslinking agents (HP:0003221)3.85586647
3Breast hypoplasia (HP:0003187)3.63195652
4Lymphangioma (HP:0100764)3.55393398
5Chromsome breakage (HP:0040012)3.42615042
6Duplicated collecting system (HP:0000081)3.37248267
7Decreased circulating renin level (HP:0003351)3.32260561
8Pendular nystagmus (HP:0012043)3.28200362
9J-shaped sella turcica (HP:0002680)3.18598114
10Reticulocytopenia (HP:0001896)3.03278231
11Abnormality of the renal collecting system (HP:0004742)3.01723544
12Right ventricular cardiomyopathy (HP:0011663)2.97154795
13Cerebral palsy (HP:0100021)2.93992531
14Abnormality of glutamine family amino acid metabolism (HP:0010902)2.90900595
15Cystic liver disease (HP:0006706)2.84512829
16Abnormal respiratory motile cilium physiology (HP:0012261)2.84148466
17Birth length less than 3rd percentile (HP:0003561)2.82574464
18Supernumerary spleens (HP:0009799)2.81585921
19Chronic bronchitis (HP:0004469)2.79637122
20Abnormal respiratory epithelium morphology (HP:0012253)2.78806779
21Abnormal respiratory motile cilium morphology (HP:0005938)2.78806779
22Dynein arm defect of respiratory motile cilia (HP:0012255)2.78093090
23Absent/shortened dynein arms (HP:0200106)2.78093090
24Proximal tubulopathy (HP:0000114)2.75564330
25Bundle branch block (HP:0011710)2.72176026
26Abnormality of glycine metabolism (HP:0010895)2.70267596
27Abnormality of serine family amino acid metabolism (HP:0010894)2.70267596
28Testicular atrophy (HP:0000029)2.65866589
29Delayed CNS myelination (HP:0002188)2.63110939
30Abnormality of the preputium (HP:0100587)2.62059693
31Amelogenesis imperfecta (HP:0000705)2.60454941
32Absent radius (HP:0003974)2.60092913
33Abnormal ciliary motility (HP:0012262)2.56569617
34Concave nail (HP:0001598)2.54736865
35Stridor (HP:0010307)2.54212687
36Ketosis (HP:0001946)2.53696795
37Progressive external ophthalmoplegia (HP:0000590)2.53505203
38Dicarboxylic aciduria (HP:0003215)2.51700548
39Abnormality of dicarboxylic acid metabolism (HP:0010995)2.51700548
40Absent forearm bone (HP:0003953)2.48582351
41Aplasia involving forearm bones (HP:0009822)2.48582351
42Ketoacidosis (HP:0001993)2.48544046
43Malnutrition (HP:0004395)2.45553545
44Hydroxyprolinuria (HP:0003080)2.44232289
45Abnormality of proline metabolism (HP:0010907)2.44232289
46Syncope (HP:0001279)2.43600264
47Confusion (HP:0001289)2.41766978
48Abnormal hair laboratory examination (HP:0003328)2.41060692
49Muscle abnormality related to mitochondrial dysfunction (HP:0003800)2.40950791
50Abnormality of pyrimidine metabolism (HP:0004353)2.40098607
51Meckel diverticulum (HP:0002245)2.38198904
52Pigmentary retinal degeneration (HP:0001146)2.37522644
53Rough bone trabeculation (HP:0100670)2.37225252
54Aplasia/Hypoplasia involving the musculature (HP:0001460)2.35820139
55Tachypnea (HP:0002789)2.35240166
56Macrocytic anemia (HP:0001972)2.35122007
57Aplasia/hypoplasia of the uterus (HP:0008684)2.33649994
58Aplasia/Hypoplasia of the sacrum (HP:0008517)2.33577313
59Impulsivity (HP:0100710)2.32369927
60Abnormality of renin-angiotensin system (HP:0000847)2.29816005
61Oligomenorrhea (HP:0000876)2.29654215
62Nephronophthisis (HP:0000090)2.29044568
63Hepatic necrosis (HP:0002605)2.28490990
64Abnormality of the ileum (HP:0001549)2.28006593
65Mesangial abnormality (HP:0001966)2.26009403
66Congenital stationary night blindness (HP:0007642)2.24812224
67True hermaphroditism (HP:0010459)2.24775118
68Pili torti (HP:0003777)2.24179962
69Abnormality of cochlea (HP:0000375)2.23177580
70Tubular atrophy (HP:0000092)2.19159864
71Oral leukoplakia (HP:0002745)2.18863191
72Hyperphosphatemia (HP:0002905)2.18235850
73Congenital ichthyosiform erythroderma (HP:0007431)2.17358597
74Late onset (HP:0003584)2.16485345
75Carpal bone hypoplasia (HP:0001498)2.15099515
76Aplasia/Hypoplasia of the uvula (HP:0010293)2.11540309
77Facial cleft (HP:0002006)2.07119389
78Rhinitis (HP:0012384)2.06895685
79Acanthosis nigricans (HP:0000956)2.06175516
80Heart block (HP:0012722)2.04907968
81Conjugated hyperbilirubinemia (HP:0002908)2.04249234
82Abnormality of the renal medulla (HP:0100957)2.04136668
83Osteomalacia (HP:0002749)2.03522189
84Abnormal trabecular bone morphology (HP:0100671)2.03082329
85Abnormality of chromosome stability (HP:0003220)2.02308436
86Genetic anticipation (HP:0003743)2.01863925
87Severe visual impairment (HP:0001141)2.01599502
88Abnormality of pyruvate family amino acid metabolism (HP:0010915)2.01456638
89Abnormality of alanine metabolism (HP:0010916)2.01456638
90Hyperalaninemia (HP:0003348)2.01456638
91Patellar aplasia (HP:0006443)2.01202264
92Hyperkalemia (HP:0002153)2.00181955
93Widely patent fontanelles and sutures (HP:0004492)1.98520722
94Onycholysis (HP:0001806)1.98219881
95Abnormality of renal resorption (HP:0011038)1.98132218
96Bronchomalacia (HP:0002780)1.97771104
97Abnormal rod and cone electroretinograms (HP:0008323)1.96619196
98Pancreatic cysts (HP:0001737)1.96463096
99Aplasia/Hypoplasia of the patella (HP:0006498)1.93628907
1003-Methylglutaconic aciduria (HP:0003535)1.91346904
101Molar tooth sign on MRI (HP:0002419)1.91310203
102Abnormality of midbrain morphology (HP:0002418)1.91310203
103Triphalangeal thumb (HP:0001199)1.90894521
104Increased muscle lipid content (HP:0009058)1.90077867
105Bone cyst (HP:0012062)1.90031669
106Abnormality of the labia minora (HP:0012880)1.89277432
107Abnormal atrioventricular conduction (HP:0005150)1.89075705
108Hepatocellular necrosis (HP:0001404)1.88937056
109Absent thumb (HP:0009777)1.88781519
110Septo-optic dysplasia (HP:0100842)1.88093201
111Hypoglycemic coma (HP:0001325)1.87887764
112Hyperglycinuria (HP:0003108)1.86319673
113Abolished electroretinogram (ERG) (HP:0000550)1.85977314
114Exercise-induced myalgia (HP:0003738)1.85866005
115Stomach cancer (HP:0012126)1.85677482
116Horseshoe kidney (HP:0000085)1.85585525
117Type II lissencephaly (HP:0007260)1.85339983
118Decreased activity of cytochrome C oxidase in muscle tissue (HP:0003688)1.84501673
119Median cleft lip (HP:0000161)1.84295517
120Insulin resistance (HP:0000855)1.83075652
121Bone marrow hypocellularity (HP:0005528)1.82763129
122Prolonged QT interval (HP:0001657)1.82695400
123Aplasia/Hypoplasia involving the carpal bones (HP:0006502)1.82269301
124Abnormal spermatogenesis (HP:0008669)1.81035675
125Ureteral duplication (HP:0000073)1.80848154
126Severe muscular hypotonia (HP:0006829)1.80606330
127Insulin-resistant diabetes mellitus (HP:0000831)1.79630262
128Clubbing of toes (HP:0100760)1.79389039
129Clumsiness (HP:0002312)1.78944879
130Woolly hair (HP:0002224)1.78033524
131Hyperactive renin-angiotensin system (HP:0000841)1.77170759
132Hyperventilation (HP:0002883)1.76907349
133Furrowed tongue (HP:0000221)1.76676316
134Microvesicular hepatic steatosis (HP:0001414)1.76079593
135Sparse eyelashes (HP:0000653)1.75954029
136Megaloblastic anemia (HP:0001889)1.75498379
137Abnormality of abdominal situs (HP:0011620)1.75247869
138Abdominal situs inversus (HP:0003363)1.75247869
139Stage 5 chronic kidney disease (HP:0003774)1.75025234
140Abnormality of cells of the erythroid lineage (HP:0012130)1.73772254
141Congenital hepatic fibrosis (HP:0002612)1.73560150
142Aplasia of the musculature (HP:0100854)1.72394554
143Amniotic constriction ring (HP:0009775)1.71817388
144Abnormality of placental membranes (HP:0011409)1.71817388
145Metabolic acidosis (HP:0001942)1.71130208
146Parakeratosis (HP:0001036)1.70109340
147Lethargy (HP:0001254)1.69103587
148Occipital encephalocele (HP:0002085)1.68567840
149Large for gestational age (HP:0001520)1.68357829
150Ileus (HP:0002595)1.67857508
151Rectal prolapse (HP:0002035)1.67750813
152Microretrognathia (HP:0000308)1.67543485
153Hyponatremia (HP:0002902)1.67466635
154Type I transferrin isoform profile (HP:0003642)1.67180749
155Muscle hypertrophy of the lower extremities (HP:0008968)1.67165455
156Long foot (HP:0001833)1.66555055
157Supernumerary bones of the axial skeleton (HP:0009144)1.66299715
158Abnormality of monocarboxylic acid metabolism (HP:0010996)1.66104394
159Duplication of thumb phalanx (HP:0009942)1.65671917
160Abnormal number of erythroid precursors (HP:0012131)1.65568046
161Azoospermia (HP:0000027)1.65252693
162Pallor (HP:0000980)1.65164226
163Increased hepatocellular lipid droplets (HP:0006565)1.64890232
164Pancreatic fibrosis (HP:0100732)1.64793909
165Popliteal pterygium (HP:0009756)1.64290369
166External ophthalmoplegia (HP:0000544)1.63543574
167Duodenal stenosis (HP:0100867)1.63438878
168Small intestinal stenosis (HP:0012848)1.63438878
169Methylmalonic aciduria (HP:0012120)1.62787407
170Renal Fanconi syndrome (HP:0001994)1.62737219
171Congenital sensorineural hearing impairment (HP:0008527)1.62485172
172Hyperammonemia (HP:0001987)1.62240723
173Morphological abnormality of the inner ear (HP:0011390)1.61709915
174Abnormality of renal excretion (HP:0011036)1.61239671
175Renal salt wasting (HP:0000127)1.60533767
176Calf muscle hypertrophy (HP:0008981)1.59561053
177Aplastic anemia (HP:0001915)1.58903441
178Gout (HP:0001997)1.58553250
179Abnormality of the renal cortex (HP:0011035)1.58244106
180Abnormality of chloride homeostasis (HP:0011422)1.57834639
181Distal lower limb muscle weakness (HP:0009053)1.57547437
182Attenuation of retinal blood vessels (HP:0007843)1.56996768
183Renal cortical cysts (HP:0000803)1.55876789
184Hyperlipoproteinemia (HP:0010980)1.54638340
185Ependymoma (HP:0002888)1.53421510
186Ventricular tachycardia (HP:0004756)1.53342680
187Abnormality of vitamin B metabolism (HP:0004340)1.52990112
188EMG: neuropathic changes (HP:0003445)1.52772414
189Abnormality of vitamin metabolism (HP:0100508)1.52205793
190Hyperthyroidism (HP:0000836)1.51375789
191Goiter (HP:0000853)1.50853494
192Myoglobinuria (HP:0002913)1.49989599
193Neoplasm of the heart (HP:0100544)1.49984866

Predicted kinase interactions (KEA)

RankGene SetZ-score
1EPHA26.06920313
2IRAK34.35846941
3PLK43.49993775
4STK163.46701469
5MAPKAPK33.43033558
6TRIB33.33769534
7SIK13.32979427
8MUSK3.18779979
9ZAK3.16668601
10BUB13.13086269
11FRK2.90008076
12TTK2.75962220
13SRPK12.47857779
14WEE12.41644137
15RIPK12.40035237
16STK38L2.12885576
17AKT32.02087491
18MST41.96471931
19PBK1.89953095
20ERN11.85220933
21PIK3CA1.82533171
22IRAK41.78845504
23IRAK21.78564945
24MAPK151.70162945
25PHKG21.69170700
26PHKG11.69170700
27IRAK11.64314034
28FER1.64100512
29VRK11.53408051
30MET1.50597576
31TLK11.49448456
32ADRBK21.48536927
33TNK21.48528637
34PRKCI1.47820068
35PRKD21.47055554
36MAP3K71.45020262
37NME11.44974117
38TSSK61.43051944
39PRKAA21.37692176
40EIF2AK11.36585238
41PLK11.34402811
42OBSCN1.31732342
43BRAF1.28435751
44DYRK31.28040979
45CHEK21.27053926
46CDK121.26914217
47CDK71.26564771
48PKN21.26519577
49MYLK1.25060591
50EEF2K1.24318252
51PAK31.23491041
52WNK31.23472380
53PRKAA11.14554589
54CDC71.14200358
55RPS6KB21.14190087
56FGFR21.12677721
57BRD41.10763773
58PRKD31.09999872
59PNCK1.09311438
60EIF2AK31.09075955
61PLK31.08513759
62ATR1.06917155
63NME21.02564047
64PTK61.02357719
65NEK21.00440319
66INSRR0.98718426
67MAP2K20.98125310
68RPS6KA20.95111958
69YES10.94054848
70DAPK20.93633082
71AURKA0.92001718
72BCKDK0.91970149
73CHUK0.91406520
74MARK10.90891255
75VRK20.89664834
76DYRK20.89023184
77AURKB0.88456300
78LATS10.88380373
79EIF2AK20.87615224
80LMTK20.83881581
81FGFR40.83365390
82GRK10.83297064
83MAP3K60.81784105
84ERBB20.81314288
85CAMK10.80529519
86PRKCE0.77746656
87WNK40.75288391
88PIM20.74115163
89HIPK20.72106259
90EPHB20.71550487
91PASK0.71503253
92MAP2K10.71315569
93STK40.71079980
94CHEK10.70793190
95MTOR0.70015680
96PRKD10.69793682
97RPS6KA60.69373511
98MKNK20.69361222
99CAMK2D0.69190886
100NLK0.67428200
101DMPK0.66199727
102ATM0.65528708
103PAK40.64364259
104PDK20.64276151
105PDPK10.62925071
106ACVR1B0.61093568
107MAP2K60.60040595
108BMPR20.58448936
109PRKCZ0.58192320
110NEK60.58020107
111BMPR1B0.57500828
112PTK20.57470649
113RPS6KC10.57125670
114RPS6KL10.57125670
115MARK20.56448053
116MAPK70.55686477
117SMG10.55275893
118ADRBK10.53936649
119CSNK2A10.52558393
120CSNK1A10.51987853
121MAP3K80.51232547
122BMX0.50376096
123STK380.49869912
124PRKG20.49799380
125PINK10.49722203
126IKBKB0.48791440
127BRSK20.47689014
128CSNK2A20.47616314
129EPHA30.47579420
130TAOK30.47268689
131CSNK1G10.47072067
132MKNK10.46038427
133TNIK0.44906816
134RPS6KA50.43868386
135TRPM70.43615795
136MAP3K30.42904420
137MAPK80.42482979
138OXSR10.42455190
139CDC42BPA0.42084218
140STK390.41590529
141TIE10.41588825
142CASK0.41357401
143TESK10.40892341
144PDK40.39985497
145PDK30.39985497
146ICK0.38652473
147PRKACA0.38374246
148CSNK1G30.38160734
149ABL20.37981592
150MAP3K110.37487494
151MAPKAPK50.37156153
152ARAF0.37104209
153KDR0.36941776
154PAK10.36734257
155ROCK10.35997316
156MST1R0.35424353
157PIM10.34184680
158NUAK10.33611724
159CDK20.32956088
160CAMK2G0.32925704
161BLK0.32532297
162ERBB40.31349702
163CSNK1E0.30351613
164STK30.29949486
165BCR0.29875728
166CDK30.28141757
167CAMK2B0.27720672
168CDK10.25922901

Predicted pathways (KEGG)

RankGene SetZ-score
1RNA polymerase_Homo sapiens_hsa030203.17182246
2Ribosome_Homo sapiens_hsa030103.14962691
3Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030082.77760976
4Mismatch repair_Homo sapiens_hsa034302.75277846
5Proteasome_Homo sapiens_hsa030502.71747573
6Fanconi anemia pathway_Homo sapiens_hsa034602.63838538
7DNA replication_Homo sapiens_hsa030302.62958189
8Pyrimidine metabolism_Homo sapiens_hsa002402.41204446
9Homologous recombination_Homo sapiens_hsa034402.15007723
10Spliceosome_Homo sapiens_hsa030402.14276120
11PPAR signaling pathway_Homo sapiens_hsa033201.95675596
12One carbon pool by folate_Homo sapiens_hsa006701.94104845
13Fatty acid degradation_Homo sapiens_hsa000711.89997110
14Basal transcription factors_Homo sapiens_hsa030221.86399830
15Folate biosynthesis_Homo sapiens_hsa007901.86268997
16Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa009701.80176202
17Pantothenate and CoA biosynthesis_Homo sapiens_hsa007701.79570960
182-Oxocarboxylic acid metabolism_Homo sapiens_hsa012101.76171558
19Nucleotide excision repair_Homo sapiens_hsa034201.75971412
20Maturity onset diabetes of the young_Homo sapiens_hsa049501.74814797
21RNA transport_Homo sapiens_hsa030131.65427449
22Vitamin digestion and absorption_Homo sapiens_hsa049771.63685099
23Base excision repair_Homo sapiens_hsa034101.58121973
24Glutathione metabolism_Homo sapiens_hsa004801.57568447
25Pentose and glucuronate interconversions_Homo sapiens_hsa000401.53688540
26Selenocompound metabolism_Homo sapiens_hsa004501.51505447
27Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa005201.50074702
28Arginine biosynthesis_Homo sapiens_hsa002201.47334985
29Fatty acid metabolism_Homo sapiens_hsa012121.43284396
30Drug metabolism - cytochrome P450_Homo sapiens_hsa009821.42709216
31Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009801.42573929
32Linoleic acid metabolism_Homo sapiens_hsa005911.42062616
33Drug metabolism - other enzymes_Homo sapiens_hsa009831.41668449
34Purine metabolism_Homo sapiens_hsa002301.41306677
35Oxidative phosphorylation_Homo sapiens_hsa001901.39422019
36Cytosolic DNA-sensing pathway_Homo sapiens_hsa046231.37064659
37Fat digestion and absorption_Homo sapiens_hsa049751.35314218
38Non-homologous end-joining_Homo sapiens_hsa034501.34941405
39Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005631.34661519
40Propanoate metabolism_Homo sapiens_hsa006401.33051860
41Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007601.32775953
42Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006011.31170439
43alpha-Linolenic acid metabolism_Homo sapiens_hsa005921.31032413
44Glycine, serine and threonine metabolism_Homo sapiens_hsa002601.29876284
45Arachidonic acid metabolism_Homo sapiens_hsa005901.29085270
46Fatty acid biosynthesis_Homo sapiens_hsa000611.25951206
47Histidine metabolism_Homo sapiens_hsa003401.25862892
48Phenylalanine metabolism_Homo sapiens_hsa003601.22043270
49Ascorbate and aldarate metabolism_Homo sapiens_hsa000531.22038978
50Synthesis and degradation of ketone bodies_Homo sapiens_hsa000721.21582535
51Arginine and proline metabolism_Homo sapiens_hsa003301.20925152
52RNA degradation_Homo sapiens_hsa030181.19379141
53Ovarian steroidogenesis_Homo sapiens_hsa049131.18638048
54Huntingtons disease_Homo sapiens_hsa050161.18159493
55Nitrogen metabolism_Homo sapiens_hsa009101.16887442
56Vitamin B6 metabolism_Homo sapiens_hsa007501.16759799
57Regulation of lipolysis in adipocytes_Homo sapiens_hsa049231.16281237
58Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001301.15776262
59Sulfur metabolism_Homo sapiens_hsa009201.14157451
60Butirosin and neomycin biosynthesis_Homo sapiens_hsa005241.13629506
61Fructose and mannose metabolism_Homo sapiens_hsa000511.13288131
62Retinol metabolism_Homo sapiens_hsa008301.13025596
63Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049641.12123337
64Protein export_Homo sapiens_hsa030601.10602827
65Cyanoamino acid metabolism_Homo sapiens_hsa004601.10200880
66Chemical carcinogenesis_Homo sapiens_hsa052041.08824125
67Cysteine and methionine metabolism_Homo sapiens_hsa002701.06879305
68Steroid biosynthesis_Homo sapiens_hsa001001.06156938
69Cardiac muscle contraction_Homo sapiens_hsa042601.05572745
70Sphingolipid metabolism_Homo sapiens_hsa006001.01765892
71p53 signaling pathway_Homo sapiens_hsa041151.01492257
72Bile secretion_Homo sapiens_hsa049761.00138908
73Mineral absorption_Homo sapiens_hsa049780.98596047
74Circadian rhythm_Homo sapiens_hsa047100.97367376
75Steroid hormone biosynthesis_Homo sapiens_hsa001400.96409973
76Sulfur relay system_Homo sapiens_hsa041220.96020214
77Insulin secretion_Homo sapiens_hsa049110.95982513
78Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010400.95828190
79Cell cycle_Homo sapiens_hsa041100.94656255
80beta-Alanine metabolism_Homo sapiens_hsa004100.94593751
81AMPK signaling pathway_Homo sapiens_hsa041520.92698618
82Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002500.91909375
83Peroxisome_Homo sapiens_hsa041460.91257959
84Terpenoid backbone biosynthesis_Homo sapiens_hsa009000.91167453
85Metabolic pathways_Homo sapiens_hsa011000.90225485
86Citrate cycle (TCA cycle)_Homo sapiens_hsa000200.87712439
87Lysine degradation_Homo sapiens_hsa003100.87664433
88Tyrosine metabolism_Homo sapiens_hsa003500.87042917
89Pentose phosphate pathway_Homo sapiens_hsa000300.84453634
90Tight junction_Homo sapiens_hsa045300.79339697
91Tryptophan metabolism_Homo sapiens_hsa003800.79153097
92Parkinsons disease_Homo sapiens_hsa050120.79103639
93Other glycan degradation_Homo sapiens_hsa005110.77318041
94Galactose metabolism_Homo sapiens_hsa000520.75547805
95Insulin resistance_Homo sapiens_hsa049310.75215646
96Glucagon signaling pathway_Homo sapiens_hsa049220.75182687
97Renin-angiotensin system_Homo sapiens_hsa046140.74042451
98Vascular smooth muscle contraction_Homo sapiens_hsa042700.73550519
99mRNA surveillance pathway_Homo sapiens_hsa030150.69296913
100Ether lipid metabolism_Homo sapiens_hsa005650.66436367
101Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008600.62725097
102Adipocytokine signaling pathway_Homo sapiens_hsa049200.61310427
103Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005330.59351931
104Taurine and hypotaurine metabolism_Homo sapiens_hsa004300.58631811
105Renin secretion_Homo sapiens_hsa049240.56605048
106Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006300.56493139
107Aldosterone synthesis and secretion_Homo sapiens_hsa049250.55897631
108Valine, leucine and isoleucine degradation_Homo sapiens_hsa002800.55769004
109Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049320.55587320
110Carbohydrate digestion and absorption_Homo sapiens_hsa049730.55561338
111Glycolysis / Gluconeogenesis_Homo sapiens_hsa000100.52821237
112Taste transduction_Homo sapiens_hsa047420.52629225
113Biosynthesis of amino acids_Homo sapiens_hsa012300.52172120
114Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006030.50605364
115Phototransduction_Homo sapiens_hsa047440.49885746
116Alzheimers disease_Homo sapiens_hsa050100.48496093
117Dilated cardiomyopathy_Homo sapiens_hsa054140.47823924
118Epstein-Barr virus infection_Homo sapiens_hsa051690.47143524
119Arrhythmogenic right ventricular cardiomyopathy (ARVC)_Homo sapiens_hsa054120.47012272
120Longevity regulating pathway - mammal_Homo sapiens_hsa042110.45501596
121Basal cell carcinoma_Homo sapiens_hsa052170.44697397
122ABC transporters_Homo sapiens_hsa020100.44171598
123Starch and sucrose metabolism_Homo sapiens_hsa005000.43617819
124Glycerophospholipid metabolism_Homo sapiens_hsa005640.42534569
125Systemic lupus erythematosus_Homo sapiens_hsa053220.42445328
126Thyroid hormone synthesis_Homo sapiens_hsa049180.40539872
127Caffeine metabolism_Homo sapiens_hsa002320.40134137
128Serotonergic synapse_Homo sapiens_hsa047260.39462657
129Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005120.39396447
130Insulin signaling pathway_Homo sapiens_hsa049100.38133265
131Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa049600.37684350
132Notch signaling pathway_Homo sapiens_hsa043300.37624228
133Primary bile acid biosynthesis_Homo sapiens_hsa001200.34376806
134Protein digestion and absorption_Homo sapiens_hsa049740.32792590
135Glycerolipid metabolism_Homo sapiens_hsa005610.31654756
136Pyruvate metabolism_Homo sapiens_hsa006200.30851040
137Hedgehog signaling pathway_Homo sapiens_hsa043400.30183981
138Collecting duct acid secretion_Homo sapiens_hsa049660.30143636
139Fatty acid elongation_Homo sapiens_hsa000620.28733492
140Butanoate metabolism_Homo sapiens_hsa006500.26254182
141Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa045500.26216677

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