ARCHS4

Functional Annotation Prediction

Predicted biological processes (GO)

Rank	Gene Set	Z-score
1	DNA methylation involved in gamete generation (GO:0043046)	7.99713961
2	* synaptonemal complex assembly (GO:0007130)	7.89747538
3	male meiosis (GO:0007140)	7.89426600
4	* synaptonemal complex organization (GO:0070193)	7.74078809
5	male meiosis I (GO:0007141)	6.55306544
6	* meiotic nuclear division (GO:0007126)	6.05559018
7	* chromosome organization involved in meiosis (GO:0070192)	5.87735541
8	cilium or flagellum-dependent cell motility (GO:0001539)	5.86056105
9	meiosis I (GO:0007127)	5.84697847
10	fusion of sperm to egg plasma membrane (GO:0007342)	5.49714766
11	nuclear pore organization (GO:0006999)	5.11543857
12	nuclear pore complex assembly (GO:0051292)	5.05650832
13	gene silencing by RNA (GO:0031047)	4.79187369
14	histone H3-K9 demethylation (GO:0033169)	4.77717774
15	* meiotic cell cycle process (GO:1903046)	4.66794160
16	positive regulation of meiosis (GO:0045836)	4.60890620
17	spermatid development (GO:0007286)	4.50862221
18	sperm-egg recognition (GO:0035036)	4.39887220
19	mitotic metaphase plate congression (GO:0007080)	4.35701335
20	binding of sperm to zona pellucida (GO:0007339)	4.35202090
21	positive regulation of meiotic cell cycle (GO:0051446)	4.31470646
22	* regulation of meiosis I (GO:0060631)	4.28311124
23	acrosome reaction (GO:0007340)	4.27321936
24	reciprocal meiotic recombination (GO:0007131)	4.17898922
25	reciprocal DNA recombination (GO:0035825)	4.17898922
26	meiotic chromosome segregation (GO:0045132)	4.16115011
27	histone exchange (GO:0043486)	4.08216911
28	DNA replication-dependent nucleosome organization (GO:0034723)	4.06180375
29	DNA replication-dependent nucleosome assembly (GO:0006335)	4.06180375
30	DNA methylation (GO:0006306)	4.04418805
31	DNA alkylation (GO:0006305)	4.04418805
32	axonemal dynein complex assembly (GO:0070286)	4.03047278
33	meiotic cell cycle (GO:0051321)	4.02861409
34	plasma membrane fusion (GO:0045026)	4.02656767
35	DNA replication checkpoint (GO:0000076)	3.98116617
36	protein K6-linked ubiquitination (GO:0085020)	3.92670810
37	pore complex assembly (GO:0046931)	3.90978306
38	cell-cell recognition (GO:0009988)	3.90322092
39	purine nucleobase biosynthetic process (GO:0009113)	3.84304081
40	sperm motility (GO:0030317)	3.81652562
41	DNA synthesis involved in DNA repair (GO:0000731)	3.79928914
42	protein targeting to Golgi (GO:0000042)	3.77008815
43	metaphase plate congression (GO:0051310)	3.76491520
44	regulation of attachment of spindle microtubules to kinetochore (GO:0051988)	3.75077556
45	* female gamete generation (GO:0007292)	3.74721449
46	gonadal mesoderm development (GO:0007506)	3.70452881
47	regulation of DNA endoreduplication (GO:0032875)	3.70336912
48	microtubule depolymerization (GO:0007019)	3.69671722
49	acrosome assembly (GO:0001675)	3.69214290
50	resolution of meiotic recombination intermediates (GO:0000712)	3.68671448
51	mitotic nuclear envelope disassembly (GO:0007077)	3.68502975
52	multicellular organism reproduction (GO:0032504)	3.67438878
53	attachment of spindle microtubules to kinetochore (GO:0008608)	3.67123153
54	proteasome assembly (GO:0043248)	3.66071214
55	regulation of histone H3-K9 methylation (GO:0051570)	3.61040205
56	nucleobase biosynthetic process (GO:0046112)	3.59373271
57	regulation of centriole replication (GO:0046599)	3.57341699
58	chromatin remodeling at centromere (GO:0031055)	3.56862977
59	establishment of protein localization to Golgi (GO:0072600)	3.55710571
60	monoubiquitinated protein deubiquitination (GO:0035520)	3.54101236
61	retrograde transport, vesicle recycling within Golgi (GO:0000301)	3.49804311
62	nuclear envelope disassembly (GO:0051081)	3.47557269
63	membrane disassembly (GO:0030397)	3.47557269
64	synapsis (GO:0007129)	3.47133385
65	motile cilium assembly (GO:0044458)	3.46586497
66	mitotic chromosome condensation (GO:0007076)	3.45399004
67	gene silencing (GO:0016458)	3.44768737
68	cell wall macromolecule catabolic process (GO:0016998)	3.43631688
69	cell wall macromolecule metabolic process (GO:0044036)	3.43631688
70	chaperone-mediated protein complex assembly (GO:0051131)	3.41510787
71	protein localization to chromosome, centromeric region (GO:0071459)	3.35410423
72	heterochromatin organization (GO:0070828)	3.34143580
73	DNA replication initiation (GO:0006270)	3.32665235
74	protein localization to kinetochore (GO:0034501)	3.32367551
75	* germ cell development (GO:0007281)	3.30299537
76	ribosome assembly (GO:0042255)	3.28946871
77	regulation of centrosome cycle (GO:0046605)	3.28871657
78	removal of superoxide radicals (GO:0019430)	3.28844077
79	cellular response to superoxide (GO:0071451)	3.28844077
80	cellular response to oxygen radical (GO:0071450)	3.28844077
81	kinetochore organization (GO:0051383)	3.28400851
82	epithelial cilium movement (GO:0003351)	3.28279520
83	DNA methylation or demethylation (GO:0044728)	3.28237209
84	histone H3-K36 demethylation (GO:0070544)	3.26385055
85	ribosome biogenesis (GO:0042254)	3.25369416
86	* gamete generation (GO:0007276)	3.25229084
87	positive regulation of chromosome segregation (GO:0051984)	3.25039422
88	fertilization (GO:0009566)	3.24545522
89	centriole replication (GO:0007099)	3.22534094
90	regulation of spindle organization (GO:0090224)	3.22435073
91	* regulation of chromosome segregation (GO:0051983)	3.22367095
92	* oogenesis (GO:0048477)	3.21472022
93	DNA replication-independent nucleosome organization (GO:0034724)	3.21462828
94	DNA replication-independent nucleosome assembly (GO:0006336)	3.21462828
95	CENP-A containing nucleosome assembly (GO:0034080)	3.17865889
96	mitotic sister chromatid segregation (GO:0000070)	3.17212995
97	mitotic sister chromatid cohesion (GO:0007064)	3.16471127
98	negative regulation of chromosome segregation (GO:0051985)	3.16124450
99	intra-S DNA damage checkpoint (GO:0031573)	3.15487337
100	chromosome condensation (GO:0030261)	3.12860041
101	epithelial cilium movement involved in determination of left/right asymmetry (GO:0060287)	3.12017530
102	negative regulation of mitotic metaphase/anaphase transition (GO:0045841)	3.10656264
103	negative regulation of sister chromatid segregation (GO:0033046)	3.10656264
104	negative regulation of mitotic sister chromatid separation (GO:2000816)	3.10656264
105	negative regulation of mitotic sister chromatid segregation (GO:0033048)	3.10656264
106	regulation of double-strand break repair via homologous recombination (GO:0010569)	3.10651941
107	* regulation of meiotic cell cycle (GO:0051445)	3.10135518
108	* male gamete generation (GO:0048232)	3.10008235
109	* spermatogenesis (GO:0007283)	3.09585652
110	regulation of mitotic metaphase/anaphase transition (GO:0030071)	3.06902191
111	spindle checkpoint (GO:0031577)	3.05743692
112	* sister chromatid cohesion (GO:0007062)	3.05207149
113	mitotic spindle checkpoint (GO:0071174)	3.04429890
114	establishment of chromosome localization (GO:0051303)	3.03976410
115	negative regulation of metaphase/anaphase transition of cell cycle (GO:1902100)	3.02428914
116	sex differentiation (GO:0007548)	3.02015113
117	regulation of metaphase/anaphase transition of cell cycle (GO:1902099)	3.00630013
118	* chromosome organization (GO:0051276)	3.00356816
119	DNA packaging (GO:0006323)	2.99813438
120	mitotic spindle assembly checkpoint (GO:0007094)	2.99632171
121	spindle assembly checkpoint (GO:0071173)	2.97927345
122	positive regulation of cellular response to oxidative stress (GO:1900409)	2.96175824
123	positive regulation of response to oxidative stress (GO:1902884)	2.96175824
124	oocyte maturation (GO:0001556)	2.93657565
125	DNA biosynthetic process (GO:0071897)	2.87233207
126	seminiferous tubule development (GO:0072520)	2.81998098
127	negative regulation of DNA damage response, signal transduction by p53 class mediator (GO:0043518)	2.80156569
128	* cellular process involved in reproduction in multicellular organism (GO:0022412)	2.79622050
129	N-terminal protein amino acid acetylation (GO:0006474)	2.79148697
130	* nuclear division (GO:0000280)	2.77466245
131	negative regulation of inclusion body assembly (GO:0090084)	2.77248901
132	spindle assembly involved in mitosis (GO:0090307)	2.74431745
133	positive regulation of mitotic sister chromatid separation (GO:1901970)	2.74130026
134	positive regulation of mitotic metaphase/anaphase transition (GO:0045842)	2.74130026
135	positive regulation of metaphase/anaphase transition of cell cycle (GO:1902101)	2.74130026
136	negative regulation of DNA repair (GO:0045738)	2.72739519
137	negative regulation of NF-kappaB import into nucleus (GO:0042347)	2.70676042
138	microtubule nucleation (GO:0007020)	2.68891916
139	rRNA methylation (GO:0031167)	2.68606784
140	protein localization to Golgi apparatus (GO:0034067)	2.68529485
141	piRNA metabolic process (GO:0034587)	10.7540447

Predicted upstream transcription factors (ChEA)

Rank	Gene Set	Z-score
1	E2F7_22180533_ChIP-Seq_HELA_Human	7.51876280
2	MYBL1_21750041_ChIP-ChIP_SPERMATOCYTES_Mouse	7.22430988
3	FOXM1_23109430_ChIP-Seq_U2OS_Human	4.16639975
4	E2F4_17652178_ChIP-ChIP_JURKAT_Human	3.51209490
5	MYC_18555785_ChIP-Seq_MESCs_Mouse	3.44635322
6	FOXM1_25889361_ChIP-Seq_OE33_AND_U2OS_Human	3.03239705
7	E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse	2.91315321
8	MYC_19079543_ChIP-ChIP_MESCs_Mouse	2.72826380
9	KDM5B_21448134_ChIP-Seq_MESCs_Mouse	2.52352533
10	SALL1_21062744_ChIP-ChIP_HESCs_Human	2.42413463
11	MYC_19030024_ChIP-ChIP_MESCs_Mouse	2.41683402
12	CREB1_15753290_ChIP-ChIP_HEK293T_Human	2.33196607
13	AR_21909140_ChIP-Seq_LNCAP_Human	2.31350625
14	KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human	2.31327944
15	JARID1A_20064375_ChIP-Seq_MESCs_Mouse	2.30859759
16	EST1_17652178_ChIP-ChIP_JURKAT_Human	2.28786838
17	* MYC_18358816_ChIP-ChIP_MESCs_Mouse	2.24968398
18	ETS1_20019798_ChIP-Seq_JURKAT_Human	2.24860174
19	* MYCN_18555785_ChIP-Seq_MESCs_Mouse	2.20691282
20	GABP_17652178_ChIP-ChIP_JURKAT_Human	2.18523483
21	TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat	2.13022572
22	IRF8_21731497_ChIP-ChIP_J774_Mouse	2.10718072
23	NELFA_20434984_ChIP-Seq_ESCs_Mouse	2.10495833
24	CHD1_19587682_ChIP-ChIP_MESCs_Mouse	2.08605526
25	KLF2_18264089_ChIP-ChIP_MESCs_Mouse	2.06293430
26	KLF5_18264089_ChIP-ChIP_MESCs_Mouse	2.06293430
27	KLF4_18264089_ChIP-ChIP_MESCs_Mouse	2.06293430
28	POU5F1_18555785_ChIP-Seq_MESCs_Mouse	2.04861914
29	* MYBL2_22936984_ChIP-ChIP_MESCs_Mouse	2.04786925
30	MYCN_21190229_ChIP-Seq_SHEP-21N_Human	2.03101020
31	* CREM_20920259_ChIP-Seq_GC1-SPG_Mouse	1.94466832
32	EKLF_21900194_ChIP-Seq_ERYTHROCYTE_Mouse	1.90793159
33	IGF1R_20145208_ChIP-Seq_DFB_Human	1.90421804
34	XRN2_22483619_ChIP-Seq_HELA_Human	1.89967635
35	VDR_23849224_ChIP-Seq_CD4+_Human	1.85888561
36	E2F1_21310950_ChIP-Seq_MCF-7_Human	1.75121765
37	SMAD1_18555785_ChIP-Seq_MESCs_Mouse	1.73056066
38	NOTCH1_21737748_ChIP-Seq_TLL_Human	1.69897824
39	NANOG_18555785_ChIP-Seq_MESCs_Mouse	1.69805063
40	CIITA_18437201_ChIP-ChIP_Raji_B_and_iDC_Human	1.65464684
41	PPARG_23326641_ChIP-Seq_C3H10T1-2_Mouse	1.64168199
42	STAT3_1855785_ChIP-Seq_MESCs_Mouse	1.62360844
43	VDR_20736230_ChIP-Seq_LYMPHOBLASTOID_Human	1.60599827
44	PRDM5_23873026_ChIP-Seq_MEFs_Mouse	1.60550449
45	RBPJ_22232070_ChIP-Seq_NCS_Mouse	1.56416251
46	GABP_19822575_ChIP-Seq_HepG2_Human	1.55055019
47	NACC1_18358816_ChIP-ChIP_MESCs_Mouse	1.54137040
48	DCP1A_22483619_ChIP-Seq_HELA_Human	1.53953514
49	HCFC1_20581084_ChIP-Seq_MESCs_Mouse	1.52948778
50	E2F1_18555785_ChIP-Seq_MESCs_Mouse	1.50805792
51	FOXP3_21729870_ChIP-Seq_TREG_Human	1.48058082
52	NANOG_18700969_ChIP-ChIP_MESCs_Mouse	1.47343604
53	TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse	1.44492015
54	ZNF274_21170338_ChIP-Seq_K562_Hela	1.42754657
55	YY1_21170310_ChIP-Seq_MESCs_Mouse	1.40923755
56	ZFP42_18358816_ChIP-ChIP_MESCs_Mouse	1.39649410
57	KDM5A_27292631_Chip-Seq_BREAST_Human	1.38871473
58	YY1_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse	1.38190465
59	POU5F1_18700969_ChIP-ChIP_MESCs_Mouse	1.36272535
60	ZFX_18555785_ChIP-Seq_MESCs_Mouse	1.35541126
61	TTF2_22483619_ChIP-Seq_HELA_Human	1.34238167
62	KLF4_18555785_ChIP-Seq_MESCs_Mouse	1.33997050
63	KAP1_22055183_ChIP-Seq_ESCs_Mouse	1.32043710
64	SOX2_18555785_ChIP-Seq_MESCs_Mouse	1.27592037
65	THAP11_20581084_ChIP-Seq_MESCs_Mouse	1.27423039
66	GATA3_26560356_Chip-Seq_TH1_Human	1.25701166
67	PADI4_21655091_ChIP-ChIP_MCF-7_Human	1.25483580
68	HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human	1.22839325
69	PKCTHETA_26484144_Chip-Seq_BREAST_Human	1.20659116
70	GATA1_26923725_Chip-Seq_HPCs_Mouse	1.20514332
71	ER_23166858_ChIP-Seq_MCF-7_Human	1.19350394
72	FUS_26573619_Chip-Seq_HEK293_Human	1.19226217
73	HOXB4_20404135_ChIP-ChIP_EML_Mouse	1.18782145
74	HOXB7_26014856_ChIP-Seq_BT474_Human	1.16652719
75	FOXA1_21572438_ChIP-Seq_LNCaP_Human	1.16578645
76	BCL11B_21912641_ChIP-Seq_STHDH_STRIUM_Mouse	1.16218515
77	POU5F1_18358816_ChIP-ChIP_MESCs_Mouse	1.15903011
78	EGR1_19374776_ChIP-ChIP_THP-1_Human	1.15003260
79	SPI1_23547873_ChIP-Seq_NB4_Human	1.14656934
80	GATA3_26560356_Chip-Seq_TH2_Human	1.09152345
81	CREB1_23762244_ChIP-Seq_HIPPOCAMPUS_Rat	1.08315499
82	SMRT_22465074_ChIP-Seq_MACROPHAGES_Mouse	1.07468921
83	FOXA1_25329375_ChIP-Seq_VCAP_Human	1.07445652
84	FOXA1_27270436_Chip-Seq_PROSTATE_Human	1.07445652
85	FOXO3_22982991_ChIP-Seq_MACROPHAGES_Mouse	1.06871243
86	ASH2L_23239880_ChIP-Seq_MESCs_Mouse	1.06447059
87	GATA3_20176728_ChIP-ChIP_TSCs_Mouse	1.05870023
88	MYB_21317192_ChIP-Seq_ERMYB_Mouse	1.00967656
89	ELK1_19687146_ChIP-ChIP_HELA_Human	1.00744416
90	SIN3A_21632747_ChIP-Seq_MESCs_Mouse	1.00619299
91	FOXH1_21741376_ChIP-Seq_EPCs_Human	0.98676713
92	* RBPJ_21746931_ChIP-Seq_IB4_Human	0.98224333
93	NANOG_21062744_ChIP-ChIP_HESCs_Human	0.97625909
94	E2F4_21247883_ChIP-Seq_LYMPHOBLASTOID_Human	0.97563532
95	GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse	0.96073090
96	ERA_21632823_ChIP-Seq_H3396_Human	0.96048820
97	* ETV1_20927104_ChIP-Seq_GIST48_Human	0.95352245
98	VDR_22108803_ChIP-Seq_LS180_Human	0.95330445
99	IRF8_22096565_ChIP-ChIP_GC-B_Mouse	0.94071951
100	NCOR_22465074_ChIP-Seq_MACROPHAGES_Mouse	0.93848209
101	* POU3F2_20337985_ChIP-ChIP_501MEL_Human	0.93100570
102	SMAD4_21741376_ChIP-Seq_EPCs_Human	0.92663853
103	FLI1_27457419_Chip-Seq_LIVER_Mouse	0.92515472
104	HSF1_23293686_ChIP-Seq_STHDH_STRIATAL_Mouse	0.91966063
105	MYB_26560356_Chip-Seq_TH2_Human	0.91306371
106	TAL1_22897851_ChIP-Seq_JUKARTE6-1_Human	0.90297398
107	PPARG_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse	0.88930569
108	TP53_22573176_ChIP-Seq_HFKS_Human	0.88785519
109	DACH1_20351289_ChIP-Seq_MDA-MB-231_Human	0.87324916
110	TCF12/HEB_22897851_ChIP-Seq_JUKARTE6-1_Human	0.87203022
111	RCOR1_19997604_ChIP-ChIP_NEURONS_Mouse	0.86343992
112	UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human	0.85868858
113	KLF4_18358816_ChIP-ChIP_MESCs_Mouse	0.85790327
114	NANOG_18358816_ChIP-ChIP_MESCs_Mouse	0.85762273
115	TCF3_18692474_ChIP-Seq_MESCs_Mouse	0.85678487
116	SPI1_22790984_ChIP-Seq_ERYTHROLEUKEMIA_Mouse	0.85624467
117	EGR1_23403033_ChIP-Seq_LIVER_Mouse	0.83725138
118	RUNX1_26923725_Chip-Seq_HPCs_Mouse	0.83593332
119	SFPI1_20887958_ChIP-Seq_HPC-7_Mouse	0.83386635
120	RUNX1_22897851_ChIP-Seq_JUKARTE6-1_Human	0.83212267
121	SOX9_22984422_ChIP-ChIP_TESTIS_Rat	0.82853856
122	BCL6_25482012_ChIP-Seq_CML-JURL-MK1_Human	0.81843255
123	SOX2_18692474_ChIP-Seq_MESCs_Mouse	0.81509037
124	AUTS2_25519132_ChIP-Seq_293T-REX_Human	0.81411056
125	IRF8_27001747_Chip-Seq_BMDM_Mouse	0.81252287
126	POU5F1_18692474_ChIP-Seq_MESCs_Mouse	0.81142592
127	ELF1_17652178_ChIP-ChIP_JURKAT_Human	0.80597634
128	CREB1_20920259_ChIP-Seq_GC1-SPG_Mouse	0.80076272
129	GRHL2_25758223_ChIP-Seq_PLACENTA_Mouse	0.79535414
130	RCOR2_21632747_ChIP-Seq_MESCs_Mouse	0.78989726
131	TCFCP2L1_18555785_ChIP-Seq_MESCs_Mouse	0.78823756
132	CCND1_20090754_ChIP-ChIP_RETINA_Mouse	0.78670317
133	SRF_21415370_ChIP-Seq_HL-1_Mouse	0.77899528
134	ZNF263_19887448_ChIP-Seq_K562_Human	0.76961059
135	TP63_19390658_ChIP-ChIP_HaCaT_Human	0.76354323
136	TCF3_18692474_ChIP-Seq_MEFs_Mouse	0.75089145
137	BCL3_23251550_ChIP-Seq_MUSCLE_Mouse	0.74839784
138	* SOX2_19030024_ChIP-ChIP_MESCs_Mouse	0.74754586
139	POU5F1_16518401_ChIP-PET_MESCs_Mouse	0.74029211
140	ZIC3_20872845_ChIP-ChIP_MESCs_Mouse	0.73222326
141	KAP1_27257070_Chip-Seq_ESCs_Mouse	0.73184650
142	NANOG_18692474_ChIP-Seq_MESCs_Mouse	0.73048676
143	TFEB_21752829_ChIP-Seq_HELA_Human	0.72855877
144	NANOG_18692474_ChIP-Seq_MEFs_Mouse	0.71956361
145	ASXL1_24218140_ChIP-Seq_BMDM_Mouse	0.71312012
146	CIITA_25753668_ChIP-Seq_RAJI_Human	0.71118495
147	NOTCH1_17114293_ChIP-ChIP_T-ALL_Human	0.70279047
148	YY1_22570637_ChIP-Seq_MALME-3M_Human	0.69730686
149	SALL4_18804426_ChIP-ChIP_MESCs_Mouse	0.67966655
150	MYC_18940864_ChIP-ChIP_HL60_Human	0.67882267

Predicted mouse phenotypes (MGI)

Rank	Gene Set	Z-score
1	MP0008877_abnormal_DNA_methylation	7.44052088
2	MP0008057_abnormal_DNA_replication	4.79831597
3	MP0005410_abnormal_fertilization	4.72877179
4	MP0010094_abnormal_chromosome_stability	4.33544408
5	MP0003693_abnormal_embryo_hatching	4.28805715
6	MP0003111_abnormal_nucleus_morphology	3.91468107
7	MP0002210_abnormal_sex_determination	3.85993058
8	MP0001929_abnormal_gametogenesis	3.81839319
9	MP0008058_abnormal_DNA_repair	3.74281469
10	MP0003698_abnormal_male_reproductive	3.34378224
11	MP0004957_abnormal_blastocyst_morpholog	3.34348173
12	MP0003077_abnormal_cell_cycle	3.29530809
13	MP0001145_abnormal_male_reproductive	3.20088658
14	MP0003786_premature_aging	3.15711567
15	MP0008995_early_reproductive_senescence	2.97465591
16	MP0000569_abnormal_digit_pigmentation	2.96902832
17	MP0000653_abnormal_sex_gland	2.81976024
18	MP0000015_abnormal_ear_pigmentation	2.72890827
19	MP0008007_abnormal_cellular_replicative	2.60077416
20	MP0002653_abnormal_ependyma_morphology	2.42833023
21	MP0003123_paternal_imprinting	2.40491002
22	MP0005174_abnormal_tail_pigmentation	2.28854672
23	MP0001730_embryonic_growth_arrest	2.11924521
24	MP0008004_abnormal_stomach_pH	2.09553218
25	MP0003718_maternal_effect	2.05921221
26	MP0002161_abnormal_fertility/fecundity	2.02895445
27	MP0008932_abnormal_embryonic_tissue	2.01223039
28	MP0003186_abnormal_redox_activity	1.90106787
29	MP0010307_abnormal_tumor_latency	1.87411506
30	MP0000350_abnormal_cell_proliferation	1.77704042
31	MP0005408_hypopigmentation	1.75954464
32	MP0002160_abnormal_reproductive_system	1.70671182
33	MP0005058_abnormal_lysosome_morphology	1.68693063
34	MP0005310_abnormal_salivary_gland	1.58756788
35	MP0000372_irregular_coat_pigmentation	1.54725274
36	MP0005380_embryogenesis_phenotype	1.49066592
37	MP0001672_abnormal_embryogenesis/_devel	1.49066592
38	MP0003878_abnormal_ear_physiology	1.47115080
39	MP0005377_hearing/vestibular/ear_phenot	1.47115080
40	MP0002095_abnormal_skin_pigmentation	1.43537336
41	MP0003183_abnormal_peptide_metabolism	1.41594541
42	MP0001697_abnormal_embryo_size	1.38672652
43	MP0002084_abnormal_developmental_patter	1.33672860
44	MP0010352_gastrointestinal_tract_polyps	1.33488649
45	MP0002085_abnormal_embryonic_tissue	1.31773382
46	MP0005075_abnormal_melanosome_morpholog	1.30047639
47	MP0001119_abnormal_female_reproductive	1.28499149
48	MP0003984_embryonic_growth_retardation	1.24692610
49	MP0002080_prenatal_lethality	1.22127396
50	MP0002088_abnormal_embryonic_growth/wei	1.20635692
51	MP0002132_abnormal_respiratory_system	1.20480291
52	MP0003890_abnormal_embryonic-extraembry	1.19595354
53	MP0003806_abnormal_nucleotide_metabolis	1.18733312
54	MP0005389_reproductive_system_phenotype	1.18408043
55	MP0004197_abnormal_fetal_growth/weight/	1.17937899
56	MP0001986_abnormal_taste_sensitivity	1.13874967
57	MP0000313_abnormal_cell_death	1.11978331
58	MP0005409_darkened_coat_color	1.11824692
59	MP0000678_abnormal_parathyroid_gland	1.11782924
60	MP0002086_abnormal_extraembryonic_tissu	1.08337485
61	MP0002877_abnormal_melanocyte_morpholog	1.06513354
62	MP0003699_abnormal_female_reproductive	1.06060121
63	MP0010368_abnormal_lymphatic_system	1.05019267
64	MP0000371_diluted_coat_color	1.03771211
65	MP0005076_abnormal_cell_differentiation	1.03066415
66	MP0004381_abnormal_hair_follicle	0.99924429
67	MP0001293_anophthalmia	0.99877198
68	MP0003941_abnormal_skin_development	0.97685525
69	MP0003724_increased_susceptibility_to	0.97356332
70	MP0001661_extended_life_span	0.95345294
71	MP0003315_abnormal_perineum_morphology	0.91716020
72	MP0003121_genomic_imprinting	0.90628900
73	MP0004808_abnormal_hematopoietic_stem	0.90499814
74	MP0002019_abnormal_tumor_incidence	0.88233123
75	MP0003136_yellow_coat_color	0.87129948
76	MP0002796_impaired_skin_barrier	0.86754966
77	MP0005647_abnormal_sex_gland	0.86562258
78	MP0003828_pulmonary_edema	0.85388577
79	MP0003936_abnormal_reproductive_system	0.80644626
80	MP0005623_abnormal_meninges_morphology	0.79475269
81	MP0003119_abnormal_digestive_system	0.78085594
82	MP0000358_abnormal_cell_content/	0.77407006
83	MP0005395_other_phenotype	0.76824973
84	MP0009697_abnormal_copulation	0.76104538
85	MP0001835_abnormal_antigen_presentation	0.75019869
86	MP0009672_abnormal_birth_weight	0.74337298
87	MP0004782_abnormal_surfactant_physiolog	0.74238108
88	MP0002075_abnormal_coat/hair_pigmentati	0.73375920
89	MP0003656_abnormal_erythrocyte_physiolo	0.72190869
90	MP0004133_heterotaxia	0.71783040
91	MP0006292_abnormal_olfactory_placode	0.70879049
92	MP0003567_abnormal_fetal_cardiomyocyte	0.68884352
93	MP0002277_abnormal_respiratory_mucosa	0.68867365
94	MP0009703_decreased_birth_body	0.66850932
95	MP0001324_abnormal_eye_pigmentation	0.66284479
96	MP0005397_hematopoietic_system_phenotyp	0.64338575
97	MP0001545_abnormal_hematopoietic_system	0.64338575
98	MP0004233_abnormal_muscle_weight	0.63160478
99	MP0003646_muscle_fatigue	0.63070487
100	MP0005384_cellular_phenotype	0.61233697
101	MP0001186_pigmentation_phenotype	0.61119441
102	MP0005621_abnormal_cell_physiology	0.60941315
103	MP0009115_abnormal_fat_cell	0.60590206
104	MP0002396_abnormal_hematopoietic_system	0.60226183
105	MP0008260_abnormal_autophagy	0.59518045
106	MP0001727_abnormal_embryo_implantation	0.59387816
107	MP0005266_abnormal_metabolism	0.59231779
108	MP0005451_abnormal_body_composition	0.58451794
109	MP0003943_abnormal_hepatobiliary_system	0.57282571
110	MP0002419_abnormal_innate_immunity	0.56600894
111	MP0003221_abnormal_cardiomyocyte_apopto	0.54986558
112	MP0003937_abnormal_limbs/digits/tail_de	0.54926527
113	MP0002928_abnormal_bile_duct	0.54818817
114	MP0002092_abnormal_eye_morphology	0.54704111
115	MP0000383_abnormal_hair_follicle	0.53984028
116	MP0002723_abnormal_immune_serum	0.53680667
117	MP0001919_abnormal_reproductive_system	0.52306206
118	MP0003861_abnormal_nervous_system	0.52259258
119	MP0002269_muscular_atrophy	0.52245047
120	MP0005376_homeostasis/metabolism_phenot	0.51733515
121	MP0001849_ear_inflammation	0.51648368
122	MP0004084_abnormal_cardiac_muscle	0.50237552
123	MP0005167_abnormal_blood-brain_barrier	0.49527117
124	MP0009785_altered_susceptibility_to	0.49277430
125	MP0001191_abnormal_skin_condition	0.49179832
126	MP0005319_abnormal_enzyme/_coenzyme	0.48014864
127	MP0000432_abnormal_head_morphology	0.43798402
128	MP0006036_abnormal_mitochondrial_physio	0.43224646
129	MP0000490_abnormal_crypts_of	0.42838948
130	MP0005670_abnormal_white_adipose	0.42275371
131	MP0002102_abnormal_ear_morphology	0.42040159
132	MP0000647_abnormal_sebaceous_gland	0.38656214
133	MP0000537_abnormal_urethra_morphology	0.38095100
134	MP0006035_abnormal_mitochondrial_morpho	0.36769590
135	MP0000428_abnormal_craniofacial_morphol	0.35743885
136	MP0000427_abnormal_hair_cycle	0.35721433
137	MP0005391_vision/eye_phenotype	0.35409511
138	MP0003115_abnormal_respiratory_system	0.35109441
139	MP0001286_abnormal_eye_development	0.33059303
140	MP0006072_abnormal_retinal_apoptosis	0.32406832
141	MP0003787_abnormal_imprinting	0.32332160
142	MP0002111_abnormal_tail_morphology	0.30856921
143	MP0001915_intracranial_hemorrhage	0.30523482

Predicted human phenotypes

Rank	Gene Set	Z-score
1	Respiratory insufficiency due to defective ciliary clearance (HP:0200073)	6.79012184
2	Volvulus (HP:0002580)	6.23629337
3	Dynein arm defect of respiratory motile cilia (HP:0012255)	5.74577379
4	Absent/shortened dynein arms (HP:0200106)	5.74577379
5	Azoospermia (HP:0000027)	5.50038821
6	Abnormal spermatogenesis (HP:0008669)	5.38793808
7	Degeneration of the lateral corticospinal tracts (HP:0002314)	4.91853146
8	Atrophy/Degeneration involving the corticospinal tracts (HP:0007372)	4.91853146
9	Abnormality of the lower motor neuron (HP:0002366)	4.61216538
10	Abnormal respiratory motile cilium physiology (HP:0012261)	4.49490279
11	Gonadotropin excess (HP:0000837)	4.37199585
12	Rhinitis (HP:0012384)	4.30198141
13	Abnormal respiratory epithelium morphology (HP:0012253)	4.26736208
14	Abnormal respiratory motile cilium morphology (HP:0005938)	4.26736208
15	Tubulointerstitial nephritis (HP:0001970)	4.26645724
16	Impulsivity (HP:0100710)	4.14563769
17	Supernumerary spleens (HP:0009799)	4.07290966
18	Abnormality of the corticospinal tract (HP:0002492)	3.94443104
19	Resting tremor (HP:0002322)	3.93640871
20	Birth length less than 3rd percentile (HP:0003561)	3.90553848
21	Chronic bronchitis (HP:0004469)	3.79372775
22	Parkinsonism with favorable response to dopaminergic medication (HP:0002548)	3.78049262
23	Breast hypoplasia (HP:0003187)	3.71371540
24	Chromsome breakage (HP:0040012)	3.69788833
25	Osteomalacia (HP:0002749)	3.65603778
26	Selective tooth agenesis (HP:0001592)	3.61009382
27	Abnormality of the anterior horn cell (HP:0006802)	3.60519375
28	Degeneration of anterior horn cells (HP:0002398)	3.60519375
29	Chromosomal breakage induced by crosslinking agents (HP:0003221)	3.59386233
30	Abnormal ciliary motility (HP:0012262)	3.42905142
31	11 pairs of ribs (HP:0000878)	3.41743032
32	Abnormality of the labia minora (HP:0012880)	3.41595587
33	Infertility (HP:0000789)	3.30362657
34	Metaphyseal cupping (HP:0003021)	3.24293864
35	Menstrual irregularities (HP:0000858)	3.18623561
36	Amyotrophic lateral sclerosis (HP:0007354)	3.15357213
37	Carpal bone hypoplasia (HP:0001498)	3.13090963
38	Ependymoma (HP:0002888)	3.12753197
39	Truncal obesity (HP:0001956)	3.07591992
40	Abnormality of chromosome stability (HP:0003220)	3.02925009
41	Horizontal nystagmus (HP:0000666)	3.00521480
42	Meckel diverticulum (HP:0002245)	3.00505166
43	Scotoma (HP:0000575)	2.97309579
44	Increased nuchal translucency (HP:0010880)	2.92209654
45	Abnormality of the preputium (HP:0100587)	2.84986724
46	Absent radius (HP:0003974)	2.81141157
47	Abnormality of the ileum (HP:0001549)	2.79693685
48	Male infertility (HP:0003251)	2.76551860
49	Upper motor neuron abnormality (HP:0002127)	2.76325419
50	Aplasia/Hypoplasia of the uvula (HP:0010293)	2.75520373
51	Aplasia/Hypoplasia of the macula (HP:0008059)	2.68816313
52	Vertebral arch anomaly (HP:0008438)	2.67337056
53	Loss of speech (HP:0002371)	2.65222605
54	Absent forearm bone (HP:0003953)	2.64703432
55	Aplasia involving forearm bones (HP:0009822)	2.64703432
56	Patellar aplasia (HP:0006443)	2.64164395
57	Nephronophthisis (HP:0000090)	2.58035011
58	Facial hemangioma (HP:0000329)	2.57331866
59	Disinhibition (HP:0000734)	2.53175756
60	Blepharitis (HP:0000498)	2.50731869
61	Nasal polyposis (HP:0100582)	2.49073741
62	Missing ribs (HP:0000921)	2.48992705
63	Flat occiput (HP:0005469)	2.48800179
64	Impaired vibration sensation in the lower limbs (HP:0002166)	2.47585866
65	Ectopic kidney (HP:0000086)	2.47520381
66	Absent thumb (HP:0009777)	2.45508473
67	Facial cleft (HP:0002006)	2.44776585
68	Aplasia/Hypoplasia of the patella (HP:0006498)	2.43740138
69	Recurrent bacterial skin infections (HP:0005406)	2.41319955
70	Aplasia/Hypoplasia involving the carpal bones (HP:0006502)	2.41291048
71	Fibular hypoplasia (HP:0003038)	2.40769725
72	Aplasia/Hypoplasia affecting the retina (HP:0008061)	2.40276435
73	Sloping forehead (HP:0000340)	2.38126453
74	Abnormality of DNA repair (HP:0003254)	2.38048515
75	Abnormality of lateral ventricle (HP:0030047)	2.37372459
76	Medulloblastoma (HP:0002885)	2.35760398
77	Duodenal stenosis (HP:0100867)	2.35279245
78	Small intestinal stenosis (HP:0012848)	2.35279245
79	Atrophy/Degeneration involving motor neurons (HP:0007373)	2.35195252
80	Abnormality of the costochondral junction (HP:0000919)	2.33750493
81	Abnormality of the renal collecting system (HP:0004742)	2.29172543
82	Oligodactyly (hands) (HP:0001180)	2.28910522
83	Bronchiectasis (HP:0002110)	2.28482227
84	Aplasia/Hypoplasia of the fovea (HP:0008060)	2.23764747
85	Hypoplasia of the fovea (HP:0007750)	2.23764747
86	Hypergonadotropic hypogonadism (HP:0000815)	2.23617579
87	Low anterior hairline (HP:0000294)	2.21289099
88	Abnormality of chromosome segregation (HP:0002916)	2.21027039
89	Abnormality of the astrocytes (HP:0100707)	2.20916777
90	Astrocytoma (HP:0009592)	2.20916777
91	Shoulder girdle muscle weakness (HP:0003547)	2.20893380
92	Cerebral hypomyelination (HP:0006808)	2.20171355
93	Breast carcinoma (HP:0003002)	2.20167904
94	Hand muscle atrophy (HP:0009130)	2.18473077
95	Oligodactyly (HP:0012165)	2.17599078
96	Oral leukoplakia (HP:0002745)	2.16563610
97	Agnosia (HP:0010524)	2.14922734
98	Congenital nonbullous ichthyosiform erythroderma (HP:0007479)	2.13904445
99	Rhabdomyosarcoma (HP:0002859)	2.13349035
100	Recurrent abscess formation (HP:0002722)	2.12111910
101	Rough bone trabeculation (HP:0100670)	2.11478071
102	Glioma (HP:0009733)	2.11281383
103	Horseshoe kidney (HP:0000085)	2.09688645
104	Abnormal lung lobation (HP:0002101)	2.08375382
105	Hypoplasia of the uterus (HP:0000013)	2.06999409
106	Proximal placement of thumb (HP:0009623)	2.06896609
107	Hypoplasia of the capital femoral epiphysis (HP:0003090)	2.06726481
108	Aplasia/hypoplasia of the humerus (HP:0006507)	2.06415271
109	Postural instability (HP:0002172)	2.06207523
110	Prominent nose (HP:0000448)	2.05316329
111	Spinal muscular atrophy (HP:0007269)	2.04256519
112	Premature ovarian failure (HP:0008209)	2.04247562
113	Hyperkalemia (HP:0002153)	2.03667825
114	Abnormality of the fovea (HP:0000493)	2.01885235
115	Abnormality of chloride homeostasis (HP:0011422)	2.01327712
116	Duplicated collecting system (HP:0000081)	2.00421789
117	Progressive external ophthalmoplegia (HP:0000590)	2.00115517
118	Hypoplasia of the radius (HP:0002984)	1.99886104
119	Delayed epiphyseal ossification (HP:0002663)	1.99658657
120	Aplasia/Hypoplasia of the earlobes (HP:0009906)	1.99486868
121	Bronchitis (HP:0012387)	1.97541510
122	Lip pit (HP:0100267)	1.95847749
123	Spontaneous abortion (HP:0005268)	1.95551956
124	Chronic hepatic failure (HP:0100626)	1.94939280
125	Neoplasm of the oral cavity (HP:0100649)	1.94678850
126	Abnormality of pyrimidine metabolism (HP:0004353)	1.94294579
127	Colon cancer (HP:0003003)	1.92230323
128	Ureteral duplication (HP:0000073)	1.90972571
129	Secondary amenorrhea (HP:0000869)	1.90473863
130	Abnormality of the carotid arteries (HP:0005344)	1.89277099
131	Neoplasm of the pancreas (HP:0002894)	1.88501605
132	Myelodysplasia (HP:0002863)	1.88414837
133	Abnormality of the duodenum (HP:0002246)	1.88150658
134	Tongue fasciculations (HP:0001308)	1.87681639
135	Uterine leiomyosarcoma (HP:0002891)	1.87265725
136	Leiomyosarcoma (HP:0100243)	1.87265725
137	Aplasia/Hypoplasia of the fibula (HP:0006492)	1.86902806
138	Gingivitis (HP:0000230)	1.86651816
139	Abnormality of the nasal mucosa (HP:0000433)	1.86390846
140	Capillary hemangiomas (HP:0005306)	1.86023421
141	Bone marrow hypocellularity (HP:0005528)	1.85106225
142	Abnormality of the renal medulla (HP:0100957)	1.84666211
143	Nephroblastoma (Wilms tumor) (HP:0002667)	1.83116769
144	Widely spaced teeth (HP:0000687)	1.82848166
145	Spastic gait (HP:0002064)	1.81890902
146	Median cleft lip (HP:0000161)	1.80979887
147	Short thumb (HP:0009778)	1.80307336
148	Abnormality of macrophages (HP:0004311)	1.78632007
149	Deviation of the thumb (HP:0009603)	1.78353923
150	Papillary thyroid carcinoma (HP:0002895)	1.77474832
151	Type II lissencephaly (HP:0007260)	1.77091696
152	Upper limb muscle weakness (HP:0003484)	1.76720162
153	Biliary tract neoplasm (HP:0100574)	1.76423156
154	Short ribs (HP:0000773)	1.76138826
155	Shawl scrotum (HP:0000049)	1.75036717
156	Insulin-resistant diabetes mellitus (HP:0000831)	1.73806758
157	Muscle fibrillation (HP:0010546)	1.72569773
158	Short humerus (HP:0005792)	1.72452755
159	Heterotopia (HP:0002282)	1.71751045
160	Rimmed vacuoles (HP:0003805)	1.71221558
161	Sandal gap (HP:0001852)	1.70701931
162	Embryonal renal neoplasm (HP:0011794)	1.69699088
163	Severe visual impairment (HP:0001141)	1.69199725
164	Ocular albinism (HP:0001107)	1.68093907
165	Abnormality of pyruvate family amino acid metabolism (HP:0010915)	1.67870784
166	Abnormality of alanine metabolism (HP:0010916)	1.67870784
167	Hyperalaninemia (HP:0003348)	1.67870784
168	Hyperpituitarism (HP:0010514)	1.67611715

Predicted kinase interactions (KEA)

Rank	Gene Set	Z-score
1	PDK3	5.72105917
2	PDK4	5.72105917
3	CDK19	4.58466297
4	WEE1	4.24323646
5	PDK2	3.90410058
6	CDC7	3.85729856
7	NEK2	3.18062012
8	BUB1	3.17323518
9	MAP3K2	3.01203651
10	ACVR1B	2.89908771
11	CDK12	2.82787494
12	MST1R	2.73967419
13	TTK	2.71585428
14	PNCK	2.55995027
15	BLK	2.43032534
16	EIF2AK1	2.10905787
17	SRPK1	2.09619385
18	PLK1	2.06414110
19	PLK4	2.02820486
20	BRSK2	1.92140200
21	NEK1	1.87684417
22	PLK2	1.87535760
23	DYRK3	1.75327513
24	LMTK2	1.61073556
25	CAMK1G	1.60982552
26	ATR	1.60422096
27	TESK1	1.58979809
28	CHEK2	1.54626445
29	KSR2	1.53393604
30	PLK3	1.46845044
31	CHEK1	1.45902587
32	FGR	1.37460015
33	OXSR1	1.36129528
34	CDK7	1.35453076
35	EPHA2	1.28944612
36	STK3	1.27836665
37	KSR1	1.27431115
38	EIF2AK3	1.26632330
39	TSSK6	1.26386222
40	STK38L	1.25860904
41	ICK	1.22707487
42	AURKB	1.17287660
43	YES1	1.17094251
44	AKT3	1.12793210
45	CCNB1	1.11574802
46	PRKD3	1.08715999
47	STK24	1.08080406
48	MKNK2	1.07679101
49	ATM	1.05829790
50	BRSK1	1.03385648
51	PIK3CG	1.02831341
52	BRD4	1.01183229
53	BMX	1.00928144
54	PASK	0.97565300
55	PDPK1	0.90568418
56	MAP2K3	0.88999690
57	AURKA	0.88737721
58	WNK3	0.84407425
59	TESK2	0.83837067
60	PDK1	0.83795935
61	CDK4	0.83362915
62	NEK9	0.82063627
63	CDK2	0.80767107
64	LATS2	0.80376203
65	MKNK1	0.79047817
66	TYK2	0.78892083
67	TYRO3	0.78159894
68	MATK	0.71121639
69	VRK1	0.71004645
70	ZAK	0.69739470
71	PDGFRB	0.64972489
72	CDK1	0.64505985
73	MAP3K5	0.63020900
74	CSF1R	0.62885725
75	MELK	0.62702295
76	STK16	0.62249072
77	MAP3K8	0.61887421
78	STK4	0.61435422
79	RAF1	0.61313144
80	MAP3K1	0.61086464
81	RPS6KB2	0.59734950
82	BMPR1B	0.57453029
83	JAK3	0.57403672
84	MTOR	0.56854514
85	EGFR	0.56581528
86	PRKCI	0.56341134
87	ALK	0.55489928
88	CSNK2A2	0.54968400
89	PINK1	0.54422408
90	PBK	0.54310154
91	PTK2B	0.53151731
92	INSRR	0.52403272
93	TAOK1	0.51787868
94	STK38	0.50294354
95	LATS1	0.49785875
96	CSNK2A1	0.48398896
97	SGK1	0.47979965
98	MAP3K9	0.47163275
99	RPS6KA4	0.46590404
100	BRAF	0.46513359
101	IRAK4	0.46366766
102	CSNK1E	0.45230073
103	PAK1	0.45031292
104	MAP3K3	0.44857534
105	MAP3K13	0.44475897
106	PAK4	0.43253611
107	BMPR2	0.41723905
108	PRKDC	0.38677080
109	MARK3	0.38428388
110	CSK	0.38169297
111	JAK2	0.38074225
112	MAP3K14	0.37107340
113	CSNK1D	0.37039331
114	NME2	0.36269276
115	CDK6	0.34693785
116	KIT	0.34615634
117	STK39	0.33452445
118	WNK4	0.33062527
119	STK11	0.29932105
120	PIM1	0.29802952
121	CDK8	0.27919451
122	GSK3B	0.27123955
123	EIF2AK2	0.26970175
124	ABL2	0.25746639
125	DYRK2	0.25182467
126	WNK1	0.25019732
127	MAPK10	0.22002496
128	TLK1	0.21766955
129	CDK3	0.21706279
130	STK10	0.21648335
131	IGF1R	0.21612175
132	NEK6	0.20644700
133	MET	0.20238795
134	MAPKAPK3	0.20123842
135	MAPK14	0.20057742
136	CDK9	0.20025994
137	RPS6KA1	0.19987927
138	SCYL2	0.19957131
139	PRKAA1	0.19850106
140	RET	0.19370401
141	MAPK8	0.14115702
142	TGFBR1	0.13777610
143	RPS6KA5	0.13524020
144	MAPK1	0.13194704
145	RPS6KB1	0.12088553
146	DYRK1B	0.11216523
147	AKT1	0.08086090

Predicted pathways (KEGG)

Rank	Gene Set	Z-score
1	Ribosome biogenesis in eukaryotes_Homo sapiens_hsa03008	4.75959378
2	RNA transport_Homo sapiens_hsa03013	3.84670241
3	DNA replication_Homo sapiens_hsa03030	3.68420786
4	Mismatch repair_Homo sapiens_hsa03430	3.63830450
5	Homologous recombination_Homo sapiens_hsa03440	3.57557388
6	Basal transcription factors_Homo sapiens_hsa03022	3.56569635
7	RNA polymerase_Homo sapiens_hsa03020	3.48903914
8	Vitamin B6 metabolism_Homo sapiens_hsa00750	3.36052218
9	Fanconi anemia pathway_Homo sapiens_hsa03460	3.33002280
10	Spliceosome_Homo sapiens_hsa03040	3.03849635
11	Cell cycle_Homo sapiens_hsa04110	3.00049402
12	Proteasome_Homo sapiens_hsa03050	2.71857579
13	Nucleotide excision repair_Homo sapiens_hsa03420	2.64701099
14	mRNA surveillance pathway_Homo sapiens_hsa03015	2.46554937
15	Pyrimidine metabolism_Homo sapiens_hsa00240	2.21284045
16	Base excision repair_Homo sapiens_hsa03410	2.08150269
17	Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa00970	2.02771326
18	Oocyte meiosis_Homo sapiens_hsa04114	1.95552995
19	RNA degradation_Homo sapiens_hsa03018	1.93934245
20	One carbon pool by folate_Homo sapiens_hsa00670	1.93372190
21	Non-homologous end-joining_Homo sapiens_hsa03450	1.91499766
22	SNARE interactions in vesicular transport_Homo sapiens_hsa04130	1.84402485
23	p53 signaling pathway_Homo sapiens_hsa04115	1.80776722
24	Selenocompound metabolism_Homo sapiens_hsa00450	1.73196838
25	Ubiquitin mediated proteolysis_Homo sapiens_hsa04120	1.66983035
26	Pentose phosphate pathway_Homo sapiens_hsa00030	1.57856141
27	Purine metabolism_Homo sapiens_hsa00230	1.52421170
28	Cysteine and methionine metabolism_Homo sapiens_hsa00270	1.29762932
29	Ribosome_Homo sapiens_hsa03010	1.28301937
30	NOD-like receptor signaling pathway_Homo sapiens_hsa04621	1.26736399
31	Progesterone-mediated oocyte maturation_Homo sapiens_hsa04914	1.24480401
32	Dorso-ventral axis formation_Homo sapiens_hsa04320	1.21493881
33	Fc gamma R-mediated phagocytosis_Homo sapiens_hsa04666	1.21355047
34	Osteoclast differentiation_Homo sapiens_hsa04380	1.20527959
35	RIG-I-like receptor signaling pathway_Homo sapiens_hsa04622	1.19828866
36	Epstein-Barr virus infection_Homo sapiens_hsa05169	1.17547912
37	Staphylococcus aureus infection_Homo sapiens_hsa05150	1.15136990
38	Biosynthesis of amino acids_Homo sapiens_hsa01230	1.13612226
39	Leishmaniasis_Homo sapiens_hsa05140	1.07528296
40	Tuberculosis_Homo sapiens_hsa05152	1.01845063
41	Phagosome_Homo sapiens_hsa04145	0.93281889
42	Pyruvate metabolism_Homo sapiens_hsa00620	0.93088076
43	Glycosaminoglycan degradation_Homo sapiens_hsa00531	0.92051242
44	Glycolysis / Gluconeogenesis_Homo sapiens_hsa00010	0.89828149
45	Huntingtons disease_Homo sapiens_hsa05016	0.87989425
46	Antigen processing and presentation_Homo sapiens_hsa04612	0.87752084
47	Toll-like receptor signaling pathway_Homo sapiens_hsa04620	0.85192224
48	Glycine, serine and threonine metabolism_Homo sapiens_hsa00260	0.80273373
49	Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa00520	0.78612655
50	Carbon metabolism_Homo sapiens_hsa01200	0.73626045
51	Pantothenate and CoA biosynthesis_Homo sapiens_hsa00770	0.73382491
52	Lysosome_Homo sapiens_hsa04142	0.70685811
53	Viral carcinogenesis_Homo sapiens_hsa05203	0.69957890
54	B cell receptor signaling pathway_Homo sapiens_hsa04662	0.68554895
55	Herpes simplex infection_Homo sapiens_hsa05168	0.67720470
56	Circadian rhythm_Homo sapiens_hsa04710	0.67656182
57	Endocytosis_Homo sapiens_hsa04144	0.67524521
58	ABC transporters_Homo sapiens_hsa02010	0.66942030
59	Linoleic acid metabolism_Homo sapiens_hsa00591	0.66841150
60	Glycerophospholipid metabolism_Homo sapiens_hsa00564	0.63996471
61	Phosphatidylinositol signaling system_Homo sapiens_hsa04070	0.63347569
62	beta-Alanine metabolism_Homo sapiens_hsa00410	0.60975119
63	Cyanoamino acid metabolism_Homo sapiens_hsa00460	0.58784115
64	N-Glycan biosynthesis_Homo sapiens_hsa00510	0.57989700
65	Shigellosis_Homo sapiens_hsa05131	0.57652607
66	Glutathione metabolism_Homo sapiens_hsa00480	0.57068293
67	alpha-Linolenic acid metabolism_Homo sapiens_hsa00592	0.57064409
68	Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa00250	0.56891284
69	Measles_Homo sapiens_hsa05162	0.56034645
70	Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa04550	0.55256179
71	HTLV-I infection_Homo sapiens_hsa05166	0.54740453
72	Toxoplasmosis_Homo sapiens_hsa05145	0.54609975
73	Folate biosynthesis_Homo sapiens_hsa00790	0.54482888
74	Systemic lupus erythematosus_Homo sapiens_hsa05322	0.54109299
75	Drug metabolism - other enzymes_Homo sapiens_hsa00983	0.52999771
76	Pathogenic Escherichia coli infection_Homo sapiens_hsa05130	0.50135492
77	Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa00630	0.50132402
78	Prostate cancer_Homo sapiens_hsa05215	0.49578113
79	Jak-STAT signaling pathway_Homo sapiens_hsa04630	0.49315651
80	Glycerolipid metabolism_Homo sapiens_hsa00561	0.49202794
81	Protein processing in endoplasmic reticulum_Homo sapiens_hsa04141	0.49007931
82	Fructose and mannose metabolism_Homo sapiens_hsa00051	0.47759876
83	Regulation of autophagy_Homo sapiens_hsa04140	0.47653496
84	Hepatitis B_Homo sapiens_hsa05161	0.47236173
85	Apoptosis_Homo sapiens_hsa04210	0.47099733
86	Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa05120	0.45189201
87	Glucagon signaling pathway_Homo sapiens_hsa04922	0.43154927
88	Transcriptional misregulation in cancer_Homo sapiens_hsa05202	0.42717227
89	Cytosolic DNA-sensing pathway_Homo sapiens_hsa04623	0.42627183
90	Vitamin digestion and absorption_Homo sapiens_hsa04977	0.42489522
91	NF-kappa B signaling pathway_Homo sapiens_hsa04064	0.42354451
92	T cell receptor signaling pathway_Homo sapiens_hsa04660	0.41851980
93	TGF-beta signaling pathway_Homo sapiens_hsa04350	0.38655889
94	Phenylalanine metabolism_Homo sapiens_hsa00360	0.38385986
95	Propanoate metabolism_Homo sapiens_hsa00640	0.38027724
96	Acute myeloid leukemia_Homo sapiens_hsa05221	0.36360832
97	Fatty acid biosynthesis_Homo sapiens_hsa00061	0.35920899
98	Citrate cycle (TCA cycle)_Homo sapiens_hsa00020	0.32929588
99	TNF signaling pathway_Homo sapiens_hsa04668	0.32770816
100	Hippo signaling pathway_Homo sapiens_hsa04390	0.31710633
101	Longevity regulating pathway - multiple species_Homo sapiens_hsa04213	0.30498200
102	Collecting duct acid secretion_Homo sapiens_hsa04966	0.29674860
103	Type II diabetes mellitus_Homo sapiens_hsa04930	0.29603918
104	Fc epsilon RI signaling pathway_Homo sapiens_hsa04664	0.29155429
105	Choline metabolism in cancer_Homo sapiens_hsa05231	0.29084681
106	Metabolic pathways_Homo sapiens_hsa01100	0.27928711
107	Tight junction_Homo sapiens_hsa04530	0.26828587
108	Malaria_Homo sapiens_hsa05144	0.26513858
109	MicroRNAs in cancer_Homo sapiens_hsa05206	0.26086002
110	ErbB signaling pathway_Homo sapiens_hsa04012	0.24711273
111	Salmonella infection_Homo sapiens_hsa05132	0.24158206
112	mTOR signaling pathway_Homo sapiens_hsa04150	0.22745563
113	MAPK signaling pathway_Homo sapiens_hsa04010	0.22254139
114	Chemokine signaling pathway_Homo sapiens_hsa04062	0.21695550
115	Non-small cell lung cancer_Homo sapiens_hsa05223	0.21581337
116	Hematopoietic cell lineage_Homo sapiens_hsa04640	0.21119787
117	Small cell lung cancer_Homo sapiens_hsa05222	0.20958367
118	Hedgehog signaling pathway_Homo sapiens_hsa04340	0.20291629
119	Influenza A_Homo sapiens_hsa05164	0.18357235
120	Hepatitis C_Homo sapiens_hsa05160	0.17473699
121	Olfactory transduction_Homo sapiens_hsa04740	0.17088560
122	Central carbon metabolism in cancer_Homo sapiens_hsa05230	0.16880350
123	Thyroid hormone signaling pathway_Homo sapiens_hsa04919	0.16336088
124	Legionellosis_Homo sapiens_hsa05134	0.14575797
125	Arachidonic acid metabolism_Homo sapiens_hsa00590	0.13551689
126	Thyroid cancer_Homo sapiens_hsa05216	0.13220528
127	Basal cell carcinoma_Homo sapiens_hsa05217	0.11037165
128	Sulfur relay system_Homo sapiens_hsa04122	0.10626968
129	Butirosin and neomycin biosynthesis_Homo sapiens_hsa00524	0.10025950
130	HIF-1 signaling pathway_Homo sapiens_hsa04066	0.08528419
131	Fat digestion and absorption_Homo sapiens_hsa04975	0.08095780
132	Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa00130	0.08030146
133	Inositol phosphate metabolism_Homo sapiens_hsa00562	0.07564315
134	Ether lipid metabolism_Homo sapiens_hsa00565	0.07223010
135	Mineral absorption_Homo sapiens_hsa04978	0.06127019
136	Longevity regulating pathway - mammal_Homo sapiens_hsa04211	0.05608180
137	Adherens junction_Homo sapiens_hsa04520	0.04350329
138	Lysine degradation_Homo sapiens_hsa00310	0.03704439
139	Renin-angiotensin system_Homo sapiens_hsa04614	0.03534002
140	Arginine and proline metabolism_Homo sapiens_hsa00330	0.03488931
141	Notch signaling pathway_Homo sapiens_hsa04330	0.03329010
142	Alcoholism_Homo sapiens_hsa05034	0.03316727
143	Terpenoid backbone biosynthesis_Homo sapiens_hsa00900	0.03081672
144	Wnt signaling pathway_Homo sapiens_hsa04310	0.02540197
145	Nicotinate and nicotinamide metabolism_Homo sapiens_hsa00760	0.02177793
146	FoxO signaling pathway_Homo sapiens_hsa04068	0.01961072
147	2-Oxocarboxylic acid metabolism_Homo sapiens_hsa01210	0.01944014

HORMAD1

Functional Annotation Prediction

Predicted biological processes (GO)

Predicted upstream transcription factors (ChEA)

Predicted mouse phenotypes (MGI)

Predicted human phenotypes

Predicted kinase interactions (KEA)

Predicted pathways (KEGG)

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