HORMAD2

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: No gene information available for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1piRNA metabolic process (GO:0034587)6.87735373
2synaptonemal complex assembly (GO:0007130)5.40053250
3histone H3-K9 demethylation (GO:0033169)5.34018752
4sperm motility (GO:0030317)5.27669287
5* sister chromatid cohesion (GO:0007062)5.18585121
6synaptonemal complex organization (GO:0070193)5.08963751
7histone H3-K36 demethylation (GO:0070544)4.90917117
8DNA methylation involved in gamete generation (GO:0043046)4.83671369
9acrosome reaction (GO:0007340)4.69874495
10male meiosis (GO:0007140)4.69072622
11* meiotic nuclear division (GO:0007126)4.20349756
12regulation of meiosis I (GO:0060631)4.19871955
13fertilization (GO:0009566)4.14260495
14DNA replication initiation (GO:0006270)4.12324003
15genitalia morphogenesis (GO:0035112)4.08532490
16nuclear pore complex assembly (GO:0051292)4.07774518
17positive regulation of meiosis (GO:0045836)4.07488272
18nuclear pore organization (GO:0006999)4.06005647
19DNA replication checkpoint (GO:0000076)4.04106254
20* chromosome organization involved in meiosis (GO:0070192)4.03992245
21mitotic nuclear envelope disassembly (GO:0007077)3.96194095
22formation of translation preinitiation complex (GO:0001731)3.95746550
23DNA replication-dependent nucleosome organization (GO:0034723)3.94791680
24DNA replication-dependent nucleosome assembly (GO:0006335)3.94791680
25DNA packaging (GO:0006323)3.94232809
26negative regulation of inclusion body assembly (GO:0090084)3.93840271
27male gamete generation (GO:0048232)3.92452126
28spermatogenesis (GO:0007283)3.92431459
29positive regulation of meiotic cell cycle (GO:0051446)3.90415039
30DNA strand elongation involved in DNA replication (GO:0006271)3.88538269
31regulation of meiotic cell cycle (GO:0051445)3.85392055
32protein K6-linked ubiquitination (GO:0085020)3.78007267
33gamete generation (GO:0007276)3.76919391
34meiotic chromosome segregation (GO:0045132)3.76433616
35protein localization to kinetochore (GO:0034501)3.73787786
36telomere maintenance via semi-conservative replication (GO:0032201)3.70842858
37mitotic metaphase plate congression (GO:0007080)3.70184759
38fusion of sperm to egg plasma membrane (GO:0007342)3.70115891
39nuclear envelope disassembly (GO:0051081)3.67649960
40membrane disassembly (GO:0030397)3.67649960
41DNA strand elongation (GO:0022616)3.65982713
42mitotic sister chromatid segregation (GO:0000070)3.65792303
43DNA alkylation (GO:0006305)3.65376853
44DNA methylation (GO:0006306)3.65376853
45positive regulation of response to oxidative stress (GO:1902884)3.65282878
46positive regulation of cellular response to oxidative stress (GO:1900409)3.65282878
47male meiosis I (GO:0007141)3.61528183
48somatic hypermutation of immunoglobulin genes (GO:0016446)3.60346568
49somatic diversification of immune receptors via somatic mutation (GO:0002566)3.60346568
50ribosome biogenesis (GO:0042254)3.59260209
51regulation of gene silencing by RNA (GO:0060966)3.56681185
52regulation of posttranscriptional gene silencing (GO:0060147)3.56681185
53regulation of gene silencing by miRNA (GO:0060964)3.56681185
54female gamete generation (GO:0007292)3.55790644
55protein localization to chromosome, centromeric region (GO:0071459)3.54775027
56regulation of DNA endoreduplication (GO:0032875)3.54200975
57sex differentiation (GO:0007548)3.53342302
58negative regulation of gene silencing (GO:0060969)3.52773758
59gene silencing by RNA (GO:0031047)3.49925924
60germ cell development (GO:0007281)3.49540750
61reciprocal DNA recombination (GO:0035825)3.48877743
62reciprocal meiotic recombination (GO:0007131)3.48877743
63reproductive system development (GO:0061458)3.48838544
64nucleobase biosynthetic process (GO:0046112)3.45455655
65* meiotic cell cycle process (GO:1903046)3.44588122
66histone exchange (GO:0043486)3.44019889
67phospholipid efflux (GO:0033700)3.43257887
68binding of sperm to zona pellucida (GO:0007339)3.43115822
69attachment of spindle microtubules to kinetochore (GO:0008608)3.39513365
70meiotic cell cycle (GO:0051321)3.39128839
71kinetochore organization (GO:0051383)3.38538196
72chromatin remodeling at centromere (GO:0031055)3.37653872
73telomere maintenance via recombination (GO:0000722)3.37476016
74regulation of histone H3-K9 methylation (GO:0051570)3.33398201
75metaphase plate congression (GO:0051310)3.30732181
76meiosis I (GO:0007127)3.30196761
77acrosome assembly (GO:0001675)3.29690554
78kinetochore assembly (GO:0051382)3.28200918
79sperm-egg recognition (GO:0035036)3.27049812
80ribosome assembly (GO:0042255)3.27003775
81regulation of microtubule-based movement (GO:0060632)3.26804080
82cellular process involved in reproduction in multicellular organism (GO:0022412)3.26254583
83DNA unwinding involved in DNA replication (GO:0006268)3.23702516
84gene silencing (GO:0016458)3.21544374
85purine nucleobase biosynthetic process (GO:0009113)3.20945963
86mitotic recombination (GO:0006312)3.20640105
87positive regulation of chromosome segregation (GO:0051984)3.19339380
88proteasome assembly (GO:0043248)3.18043143
89pore complex assembly (GO:0046931)3.17011937
90CENP-A containing nucleosome assembly (GO:0034080)3.16903762
91regulation of double-strand break repair via homologous recombination (GO:0010569)3.16117533
92DNA biosynthetic process (GO:0071897)3.14821255
93spermatid development (GO:0007286)3.14105843
94heterochromatin organization (GO:0070828)3.11087039
95DNA replication-independent nucleosome organization (GO:0034724)3.10714407
96DNA replication-independent nucleosome assembly (GO:0006336)3.10714407
97pre-miRNA processing (GO:0031054)3.10617807
98protein targeting to Golgi (GO:0000042)3.10541775
99single strand break repair (GO:0000012)3.10028896
100microtubule depolymerization (GO:0007019)3.09812248
101regulation of helicase activity (GO:0051095)3.09193918
102sperm capacitation (GO:0048240)3.08161125
103negative regulation of chromosome segregation (GO:0051985)3.06693465
104maintenance of fidelity involved in DNA-dependent DNA replication (GO:0045005)3.06252349
105regulation of chromosome segregation (GO:0051983)3.05164270
106regulation of nuclear cell cycle DNA replication (GO:0033262)3.04700106
107high-density lipoprotein particle remodeling (GO:0034375)3.04687352
108establishment of protein localization to Golgi (GO:0072600)3.04386934
109* chromosome organization (GO:0051276)3.02562239
110establishment of chromosome localization (GO:0051303)3.02062007
111sister chromatid segregation (GO:0000819)3.01922111
112rRNA modification (GO:0000154)3.01299001
113DNA deamination (GO:0045006)3.01045304
114chaperone-mediated protein complex assembly (GO:0051131)3.00512153
115telomere maintenance via telomere lengthening (GO:0010833)3.00372923
116DNA double-strand break processing (GO:0000729)2.99741720
117epithelial cilium movement (GO:0003351)2.99491015
118signal complex assembly (GO:0007172)2.98076756
119regulation of centriole replication (GO:0046599)2.98050597
120DNA duplex unwinding (GO:0032508)2.97394328
121chromosome condensation (GO:0030261)2.96829699
122multicellular organism reproduction (GO:0032504)2.96187818
123multicellular organismal reproductive process (GO:0048609)2.95951247
124histone H4-K12 acetylation (GO:0043983)2.95504443
125intra-S DNA damage checkpoint (GO:0031573)2.95232302
126negative regulation of meiosis (GO:0045835)2.95057297
127DNA geometric change (GO:0032392)2.94954429
128regulation of centrosome cycle (GO:0046605)2.94714810
129axonemal dynein complex assembly (GO:0070286)2.92724182
130positive regulation of protein ubiquitination involved in ubiquitin-dependent protein catabolic proc2.92309690
131ribonucleoprotein complex biogenesis (GO:0022613)2.92259776
132regulation of double-strand break repair (GO:2000779)2.90620428
133cilium or flagellum-dependent cell motility (GO:0001539)2.90547870
134centriole replication (GO:0007099)2.90120163
135negative regulation of sister chromatid segregation (GO:0033046)2.89750599
136negative regulation of mitotic sister chromatid separation (GO:2000816)2.89750599
137negative regulation of mitotic sister chromatid segregation (GO:0033048)2.89750599
138negative regulation of mitotic metaphase/anaphase transition (GO:0045841)2.89750599
139cell-cell recognition (GO:0009988)2.89584417
140positive regulation of mitotic sister chromatid separation (GO:1901970)2.89436847
141positive regulation of mitotic metaphase/anaphase transition (GO:0045842)2.89436847
142positive regulation of metaphase/anaphase transition of cell cycle (GO:1902101)2.89436847
143resolution of meiotic recombination intermediates (GO:0000712)2.89328650
144mitotic chromosome condensation (GO:0007076)2.88789888
145embryonic body morphogenesis (GO:0010172)2.81851568
146regulation of cilium movement (GO:0003352)2.81297263
147regulation of transcription from RNA polymerase I promoter (GO:0006356)2.80955237
148regulation of female receptivity (GO:0045924)2.79113127
149spermatid nucleus differentiation (GO:0007289)2.78491863
150DNA methylation or demethylation (GO:0044728)2.75894379
151phosphatidylethanolamine metabolic process (GO:0046337)2.74391837
152centriole assembly (GO:0098534)2.73310387
153retrograde transport, vesicle recycling within Golgi (GO:0000301)2.71225351
154phosphatidylethanolamine biosynthetic process (GO:0006646)2.70806092
155negative regulation of cyclin-dependent protein serine/threonine kinase activity (GO:0045736)2.67791930
156plasma membrane fusion (GO:0045026)2.65344593
157regulation of cholesterol esterification (GO:0010872)2.65334988
158cellular ketone body metabolic process (GO:0046950)2.64507548
159protein polyglutamylation (GO:0018095)2.62468310
160negative regulation of sterol transport (GO:0032372)2.61677188
161negative regulation of cholesterol transport (GO:0032375)2.61677188
162plasma lipoprotein particle assembly (GO:0034377)2.61668353
163macroautophagy (GO:0016236)2.59119836
164very-low-density lipoprotein particle assembly (GO:0034379)2.58204550
165negative regulation of DNA damage response, signal transduction by p53 class mediator (GO:0043518)2.57924330
166histone lysine demethylation (GO:0070076)2.57396878
167* nuclear division (GO:0000280)2.54615547
168regulation of inclusion body assembly (GO:0090083)2.53300917
169protein-lipid complex assembly (GO:0065005)2.52617125
170histone demethylation (GO:0016577)2.51415526
171synapsis (GO:0007129)15.4885947
172DNA synthesis involved in DNA repair (GO:0000731)11.3675216

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1E2F7_22180533_ChIP-Seq_HELA_Human7.43881737
2MYBL1_21750041_ChIP-ChIP_SPERMATOCYTES_Mouse4.78909177
3FOXM1_23109430_ChIP-Seq_U2OS_Human3.77618810
4MYC_18555785_ChIP-Seq_MESCs_Mouse3.77242288
5E2F4_17652178_ChIP-ChIP_JURKAT_Human3.25003530
6IGF1R_20145208_ChIP-Seq_DFB_Human2.95106462
7MYC_19079543_ChIP-ChIP_MESCs_Mouse2.89061713
8EKLF_21900194_ChIP-Seq_ERYTHROCYTE_Mouse2.85706104
9FOXM1_25889361_ChIP-Seq_OE33_AND_U2OS_Human2.84644099
10MYC_19030024_ChIP-ChIP_MESCs_Mouse2.59686955
11* MYC_18358816_ChIP-ChIP_MESCs_Mouse2.58258241
12FUS_26573619_Chip-Seq_HEK293_Human2.58109984
13E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse2.57469468
14CTBP2_25329375_ChIP-Seq_LNCAP_Human2.49570083
15EZH2_22144423_ChIP-Seq_EOC_Human2.43038659
16RNF2_27304074_Chip-Seq_NSC_Mouse2.42287496
17JARID1A_20064375_ChIP-Seq_MESCs_Mouse2.39386835
18BCAT_22108803_ChIP-Seq_LS180_Human2.37627772
19ZNF274_21170338_ChIP-Seq_K562_Hela2.36481066
20KLF2_18264089_ChIP-ChIP_MESCs_Mouse2.34812978
21KLF5_18264089_ChIP-ChIP_MESCs_Mouse2.34812978
22KLF4_18264089_ChIP-ChIP_MESCs_Mouse2.34812978
23KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human2.33167692
24ER_23166858_ChIP-Seq_MCF-7_Human2.33135889
25EST1_17652178_ChIP-ChIP_JURKAT_Human2.27703115
26SMAD1_18555785_ChIP-Seq_MESCs_Mouse2.24873602
27CHD1_19587682_ChIP-ChIP_MESCs_Mouse2.19143847
28ETS1_20019798_ChIP-Seq_JURKAT_Human2.15482815
29GABP_17652178_ChIP-ChIP_JURKAT_Human2.15346712
30EGR1_23403033_ChIP-Seq_LIVER_Mouse2.11934658
31* POU5F1_18555785_ChIP-Seq_MESCs_Mouse2.04603470
32BMI1_23680149_ChIP-Seq_NPCS_Mouse2.04559801
33POU5F1_26923725_Chip-Seq_MESODERM_Mouse2.02890918
34TEAD4_26923725_Chip-Seq_HEMANGIOBLAST_Mouse2.02890918
35NELFA_20434984_ChIP-Seq_ESCs_Mouse2.02725278
36MYCN_18555785_ChIP-Seq_MESCs_Mouse2.02002865
37* CTBP1_25329375_ChIP-Seq_LNCAP_Human1.98357700
38VDR_22108803_ChIP-Seq_LS180_Human1.97166638
39CREB1_15753290_ChIP-ChIP_HEK293T_Human1.95518312
40ERA_21632823_ChIP-Seq_H3396_Human1.92119299
41* MYBL2_22936984_ChIP-ChIP_MESCs_Mouse1.89616888
42MYCN_21190229_ChIP-Seq_SHEP-21N_Human1.89043908
43POU3F2_20337985_ChIP-ChIP_501MEL_Human1.87887702
44NANOG_18555785_ChIP-Seq_MESCs_Mouse1.87675831
45VDR_23849224_ChIP-Seq_CD4+_Human1.86653773
46SMAD4_21741376_ChIP-Seq_EPCs_Human1.85768677
47CBP_20019798_ChIP-Seq_JUKART_Human1.84093419
48IRF4_20064451_ChIP-Seq_CD4+T_Mouse1.84093419
49UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human1.81713614
50TAF15_26573619_Chip-Seq_HEK293_Human1.79760028
51KLF5_20875108_ChIP-Seq_MESCs_Mouse1.78299341
52POU5F1_18700969_ChIP-ChIP_MESCs_Mouse1.78142919
53XRN2_22483619_ChIP-Seq_HELA_Human1.76619430
54* KDM5B_21448134_ChIP-Seq_MESCs_Mouse1.74050561
55HCFC1_20581084_ChIP-Seq_MESCs_Mouse1.70302389
56* E2F1_18555785_ChIP-Seq_MESCs_Mouse1.69964475
57AR_25329375_ChIP-Seq_VCAP_Human1.68149079
58NOTCH1_17114293_ChIP-ChIP_T-ALL_Human1.67536248
59STAT3_23295773_ChIP-Seq_U87_Human1.67206520
60VDR_20736230_ChIP-Seq_LYMPHOBLASTOID_Human1.67162252
61YY1_21170310_ChIP-Seq_MESCs_Mouse1.66959987
62AR_21909140_ChIP-Seq_LNCAP_Human1.64701086
63STAT3_1855785_ChIP-Seq_MESCs_Mouse1.64609876
64NACC1_18358816_ChIP-ChIP_MESCs_Mouse1.64464392
65RUNX2_22187159_ChIP-Seq_PCA_Human1.61686898
66E2F1_21310950_ChIP-Seq_MCF-7_Human1.60520431
67SMAD2/3_21741376_ChIP-Seq_EPCs_Human1.60410342
68GABP_19822575_ChIP-Seq_HepG2_Human1.60181789
69FOXP3_21729870_ChIP-Seq_TREG_Human1.58192186
70NANOG_18700969_ChIP-ChIP_MESCs_Mouse1.58095892
71SOX2_19829295_ChIP-Seq_ESCs_Human1.57347347
72NANOG_19829295_ChIP-Seq_ESCs_Human1.57347347
73P300_19829295_ChIP-Seq_ESCs_Human1.55809078
74* YY1_22570637_ChIP-Seq_MALME-3M_Human1.55152016
75PRDM16_22522345_ChIP-ChIP_PALATE_MESENCHYMAL_Mouse1.54138736
76PHF8_20622853_ChIP-Seq_HELA_Human1.53398519
77EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human1.51337074
78TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.49674123
79GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.49056930
80DCP1A_22483619_ChIP-Seq_HELA_Human1.48650546
81PBX1_22567123_ChIP-ChIP_OVCAR3_Human1.47636164
82AUTS2_25519132_ChIP-Seq_293T-REX_Human1.47099031
83ETV1_20927104_ChIP-Seq_GIST48_Human1.45830354
84PPARG_23326641_ChIP-Seq_C3H10T1-2_Mouse1.45757071
85HTT_18923047_ChIP-ChIP_STHdh_Human1.45529378
86THAP11_20581084_ChIP-Seq_MESCs_Mouse1.44078004
87POU5F1_18358816_ChIP-ChIP_MESCs_Mouse1.43404452
88GATA3_26560356_Chip-Seq_TH1_Human1.40582953
89ZFP42_18358816_ChIP-ChIP_MESCs_Mouse1.39407453
90* TCF4_23295773_ChIP-Seq_U87_Human1.36872006
91EGR1_19374776_ChIP-ChIP_THP-1_Human1.34621934
92KLF4_18555785_ChIP-Seq_MESCs_Mouse1.33526296
93CDX2_21074721_ChIP-Seq_CACO-2_Mouse1.33508573
94KDM5A_27292631_Chip-Seq_BREAST_Human1.32995974
95SPI1_22790984_ChIP-Seq_ERYTHROLEUKEMIA_Mouse1.32714905
96CEBPB_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.31057443
97TTF2_22483619_ChIP-Seq_HELA_Human1.31045614
98OCT4_20526341_ChIP-Seq_ESCs_Human1.30476460
99RAC3_21632823_ChIP-Seq_H3396_Human1.30377872
100FOXH1_21741376_ChIP-Seq_EPCs_Human1.29742470
101RNF2_16625203_ChIP-ChIP_MESCs_Mouse1.29530741
102ZFX_18555785_ChIP-Seq_MESCs_Mouse1.29139007
103TCF4_22108803_ChIP-Seq_LS180_Human1.29129721
104RCOR1_19997604_ChIP-ChIP_NEURONS_Mouse1.28939032
105FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse1.28376881
106CDX2_22108803_ChIP-Seq_LS180_Human1.28223464
107CREM_20920259_ChIP-Seq_GC1-SPG_Mouse1.28020869
108* MYC_19829295_ChIP-Seq_ESCs_Human1.27917733
109PRDM14_20953172_ChIP-Seq_ESCs_Human1.27876918
110TBL1_22424771_ChIP-Seq_293T_Human1.27568498
111RUNX1_26923725_Chip-Seq_HPCs_Mouse1.27426987
112FOXA1_21572438_ChIP-Seq_LNCaP_Human1.27410902
113WDR5_24793694_ChIP-Seq_LNCAP_Human1.26786624
114KLF4_18358816_ChIP-ChIP_MESCs_Mouse1.26553924
115CEBPB_26923725_Chip-Seq_MESODERM_Mouse1.25703116
116TAL1_22897851_ChIP-Seq_JUKARTE6-1_Human1.23743883
117NFYB_21822215_ChIP-Seq_K562_Human1.23684891
118ESR1_17901129_ChIP-ChIP_LIVER_Mouse1.23571513
119RBPJ_21746931_ChIP-Seq_IB4_Human1.23464251
120HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human1.21726001
121ERA_27197147_Chip-Seq_ENDOMETRIOID-ADENOCARCINOMA_Human1.20869209
122TCF12/HEB_22897851_ChIP-Seq_JUKARTE6-1_Human1.20335991
123CHD7_19251738_ChIP-ChIP_MESCs_Mouse1.20161083
124YY1_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse1.19838645
125TOP2B_26459242_ChIP-Seq_MCF-7_Human1.19628012
126SALL1_21062744_ChIP-ChIP_HESCs_Human1.19398173
127SMAD3_21741376_ChIP-Seq_EPCs_Human1.19333419
128SOX2_18555785_ChIP-Seq_MESCs_Mouse1.18374363
129FOXA1_27270436_Chip-Seq_PROSTATE_Human1.17930264
130FOXA1_25329375_ChIP-Seq_VCAP_Human1.17930264
131MYCN_19997598_ChIP-ChIP_NEUROBLASTOMA_Human1.17628024
132HNFA_21074721_ChIP-Seq_CACO-2_Human1.17589982
133AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human1.15934337
134SETDB1_19884257_ChIP-Seq_MESCs_Mouse1.15001149
135ERG_20517297_ChIP-Seq_VCAP_Human1.14360163
136HOXB7_26014856_ChIP-Seq_BT474_Human1.14146190
137NANOG_21062744_ChIP-ChIP_HESCs_Human1.14061297
138* SMARCD1_25818293_ChIP-Seq_ESCs_Mouse1.13398573
139TCF3_18692474_ChIP-Seq_MEFs_Mouse1.12710232
140NANOG_18358816_ChIP-ChIP_MESCs_Mouse1.12623654
141CBP_21632823_ChIP-Seq_H3396_Human1.11884351
142GATA3_21878914_ChIP-Seq_MCF-7_Human1.11574434
143SMAD4_21799915_ChIP-Seq_A2780_Human1.11371774
144TCF3_18692474_ChIP-Seq_MESCs_Mouse1.10378846
145CIITA_18437201_ChIP-ChIP_Raji_B_and_iDC_Human1.10312211
146PCGF4_22325352_ChIP-Seq_293T-Rex_Human1.09548170
147EWS_26573619_Chip-Seq_HEK293_Human1.08797086
148CEBPA_26348894_ChIP-Seq_LIVER_Mouse1.08483835
149* NANOG_20526341_ChIP-Seq_ESCs_Human1.07768337
150* EBNA1_20929547_Chip-Seq_RAJI-cells_Human1.07678056
151TAL1_20887958_ChIP-Seq_HPC-7_Mouse1.07605146
152MYC_22102868_ChIP-Seq_BL_Human1.06478353
153CBX2_27304074_Chip-Seq_ESCs_Mouse1.06294547
154SRF_21415370_ChIP-Seq_HL-1_Mouse1.06076115
155DACH1_20351289_ChIP-Seq_MDA-MB-231_Human1.05211816
156ESR1_20079471_ChIP-ChIP_T-47D_Human1.05151960
157GATA6_21074721_ChIP-Seq_CACO-2_Human1.04850580
158TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat1.04817364
159PKCTHETA_26484144_Chip-Seq_BREAST_Human1.03921364
160NOTCH1_21737748_ChIP-Seq_TLL_Human1.03618436
161GRHL2_25758223_ChIP-Seq_PLACENTA_Mouse1.02847650
162ASH2L_23239880_ChIP-Seq_MESCs_Mouse1.02604698
163CBX2_22325352_ChIP-Seq_293T-Rex_Human1.01932917
164SMC4_20622854_ChIP-Seq_HELA_Human1.01375862
165CEBPB_22108803_ChIP-Seq_LS180_Human1.00734868
166NFYA_21822215_ChIP-Seq_K562_Human1.00378994
167FOXO3_22982991_ChIP-Seq_MACROPHAGES_Mouse1.00276639
168HOXB4_20404135_ChIP-ChIP_EML_Mouse0.99907373
169CCND1_20090754_ChIP-ChIP_RETINA_Mouse0.98657961
170NR0B1_18358816_ChIP-ChIP_MESCs_Mouse0.98365325
171SOX2_18358816_ChIP-ChIP_MESCs_Mouse0.97980653
172ASXL1_24218140_ChIP-Seq_BMDM_Mouse0.95853674
173PADI4_21655091_ChIP-ChIP_MCF-7_Human0.94877689
174E2F4_21247883_ChIP-Seq_LYMPHOBLASTOID_Human0.94499427
175* POU5F1_18692474_ChIP-Seq_MESCs_Mouse0.94318957
176SFPI1_20887958_ChIP-Seq_HPC-7_Mouse0.93679758
177ELK1_19687146_ChIP-ChIP_HELA_Human0.93281981
178SIN3A_21632747_ChIP-Seq_MESCs_Mouse0.92182904
179SOX2_18692474_ChIP-Seq_MESCs_Mouse0.89504617
180TFEB_21752829_ChIP-Seq_HELA_Human0.89398134
181CREB1_23762244_ChIP-Seq_HIPPOCAMPUS_Rat0.89276387
182FLI1_20887958_ChIP-Seq_HPC-7_Mouse0.89208447
183POU5F1_16518401_ChIP-PET_MESCs_Mouse0.88486990
184SOX2_18692474_ChIP-Seq_MEFs_Mouse0.86455523
185CIITA_25753668_ChIP-Seq_RAJI_Human0.86379531
186BCL3_23251550_ChIP-Seq_MUSCLE_Mouse0.86363802
187ELF1_17652178_ChIP-ChIP_JURKAT_Human0.84915200
188KAP1_27257070_Chip-Seq_ESCs_Mouse0.83676633
189SPI1_22096565_ChIP-ChIP_GC-B_Mouse0.82215901
190ZFP281_18358816_ChIP-ChIP_MESCs_Mouse0.81392436
191ERG_20887958_ChIP-Seq_HPC-7_Mouse0.81089575
192CEBPB_23403033_ChIP-Seq_LIVER_Mouse0.80005028
193TP63_19390658_ChIP-ChIP_HaCaT_Human0.79280286
194OCT4_18692474_ChIP-Seq_MEFs_Mouse0.78883804

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0008057_abnormal_DNA_replication4.80917681
2MP0010094_abnormal_chromosome_stability4.68136581
3MP0003111_abnormal_nucleus_morphology4.32468787
4MP0008877_abnormal_DNA_methylation4.16254944
5MP0003693_abnormal_embryo_hatching4.12740295
6MP0004957_abnormal_blastocyst_morpholog3.78972024
7MP0008058_abnormal_DNA_repair3.61110581
8MP0003077_abnormal_cell_cycle3.40405230
9MP0005410_abnormal_fertilization3.28538971
10MP0000678_abnormal_parathyroid_gland3.04121462
11MP0001929_abnormal_gametogenesis2.84228306
12MP0002210_abnormal_sex_determination2.71075809
13MP0000569_abnormal_digit_pigmentation2.68601441
14MP0005360_urolithiasis2.46130473
15MP0003786_premature_aging2.44365745
16MP0008007_abnormal_cellular_replicative2.40857126
17MP0001145_abnormal_male_reproductive2.38375931
18MP0003806_abnormal_nucleotide_metabolis2.24248515
19MP0003698_abnormal_male_reproductive2.23778655
20MP0010352_gastrointestinal_tract_polyps2.23223117
21MP0008004_abnormal_stomach_pH2.20216009
22MP0002876_abnormal_thyroid_physiology2.14967289
23MP0000350_abnormal_cell_proliferation2.10381757
24MP0001730_embryonic_growth_arrest2.08401433
25MP0008932_abnormal_embryonic_tissue2.05695312
26MP0005670_abnormal_white_adipose2.05057916
27MP0000653_abnormal_sex_gland2.02768489
28MP0002653_abnormal_ependyma_morphology2.02464091
29MP0003718_maternal_effect1.98650949
30MP0003646_muscle_fatigue1.94056685
31MP0010307_abnormal_tumor_latency1.89515799
32MP0003890_abnormal_embryonic-extraembry1.78198705
33MP0006292_abnormal_olfactory_placode1.69372804
34MP0001672_abnormal_embryogenesis/_devel1.67528973
35MP0005380_embryogenesis_phenotype1.67528973
36MP0005365_abnormal_bile_salt1.67272819
37MP0001697_abnormal_embryo_size1.64301901
38MP0002139_abnormal_hepatobiliary_system1.61033608
39MP0002396_abnormal_hematopoietic_system1.60850158
40MP0001986_abnormal_taste_sensitivity1.59703821
41MP0008995_early_reproductive_senescence1.56759241
42MP0003195_calcinosis1.49287993
43MP0003123_paternal_imprinting1.46601821
44MP0002161_abnormal_fertility/fecundity1.46311411
45MP0002085_abnormal_embryonic_tissue1.45278745
46MP0005085_abnormal_gallbladder_physiolo1.44986672
47MP0000313_abnormal_cell_death1.44830111
48MP0002086_abnormal_extraembryonic_tissu1.44086710
49MP0003984_embryonic_growth_retardation1.42746876
50MP0002084_abnormal_developmental_patter1.41956040
51MP0009278_abnormal_bone_marrow1.41583496
52MP0002088_abnormal_embryonic_growth/wei1.37810425
53MP0000490_abnormal_crypts_of1.36726370
54MP0005397_hematopoietic_system_phenotyp1.35182672
55MP0001545_abnormal_hematopoietic_system1.35182672
56MP0002019_abnormal_tumor_incidence1.34611365
57MP0004197_abnormal_fetal_growth/weight/1.33990270
58MP0002080_prenatal_lethality1.33915151
59MP0001293_anophthalmia1.27198878
60MP0002138_abnormal_hepatobiliary_system1.17865704
61MP0001119_abnormal_female_reproductive1.17538694
62MP0003941_abnormal_skin_development1.15880801
63MP0009840_abnormal_foam_cell1.14636686
64MP0005551_abnormal_eye_electrophysiolog1.12074599
65MP0001485_abnormal_pinna_reflex1.11146096
66MP0001968_abnormal_touch/_nociception1.08483640
67MP0004808_abnormal_hematopoietic_stem1.08254292
68MP0004133_heterotaxia1.07430614
69MP0000358_abnormal_cell_content/1.02752468
70MP0003186_abnormal_redox_activity1.01981755
71MP0005075_abnormal_melanosome_morpholog1.00793218
72MP0002722_abnormal_immune_system1.00208920
73MP0000689_abnormal_spleen_morphology0.99257510
74MP0001666_abnormal_nutrient_absorption0.98838326
75MP0003763_abnormal_thymus_physiology0.97194763
76MP0004019_abnormal_vitamin_homeostasis0.96457337
77MP0002249_abnormal_larynx_morphology0.95769663
78MP0000703_abnormal_thymus_morphology0.95098900
79MP0000681_abnormal_thyroid_gland0.94068315
80MP0008789_abnormal_olfactory_epithelium0.91918294
81MP0003567_abnormal_fetal_cardiomyocyte0.91167261
82MP0002398_abnormal_bone_marrow0.90184797
83MP0003699_abnormal_female_reproductive0.88705104
84MP0002160_abnormal_reproductive_system0.88683075
85MP0006036_abnormal_mitochondrial_physio0.87111977
86MP0003191_abnormal_cellular_cholesterol0.85891536
87MP0000566_synostosis0.85759470
88MP0003136_yellow_coat_color0.84624451
89MP0003879_abnormal_hair_cell0.83518268
90MP0002282_abnormal_trachea_morphology0.83214579
91MP0000427_abnormal_hair_cycle0.83163457
92MP0005389_reproductive_system_phenotype0.82850320
93MP0005647_abnormal_sex_gland0.81340537
94MP0005266_abnormal_metabolism0.79633044
95MP0010329_abnormal_lipoprotein_level0.79632225
96MP0000383_abnormal_hair_follicle0.79264923
97MP0006035_abnormal_mitochondrial_morpho0.78690346
98MP0001664_abnormal_digestion0.78289189
99MP0002405_respiratory_system_inflammati0.78074407
100MP0003878_abnormal_ear_physiology0.74922048
101MP0005377_hearing/vestibular/ear_phenot0.74922048
102MP0009333_abnormal_splenocyte_physiolog0.74701751
103MP0005076_abnormal_cell_differentiation0.73952166
104MP0002429_abnormal_blood_cell0.72569409
105MP0003937_abnormal_limbs/digits/tail_de0.72089879
106MP0003119_abnormal_digestive_system0.69995568
107MP0005395_other_phenotype0.69050397
108MP0003283_abnormal_digestive_organ0.68896826
109MP0000015_abnormal_ear_pigmentation0.68694809
110MP0001984_abnormal_olfaction0.68291957
111MP0002132_abnormal_respiratory_system0.67225867
112MP0003880_abnormal_central_pattern0.67197363
113MP0005174_abnormal_tail_pigmentation0.67040618
114MP0003938_abnormal_ear_development0.64952413
115MP0001919_abnormal_reproductive_system0.64495498
116MP0005023_abnormal_wound_healing0.64188514
117MP0002269_muscular_atrophy0.64150814
118MP0001963_abnormal_hearing_physiology0.64118964
119MP0001501_abnormal_sleep_pattern0.61511046
120MP0003936_abnormal_reproductive_system0.60775657
121MP0005384_cellular_phenotype0.60090302
122MP0000716_abnormal_immune_system0.59727320
123MP0009697_abnormal_copulation0.59566994
124MP0003868_abnormal_feces_composition0.58821331
125MP0009785_altered_susceptibility_to0.58099646
126MP0010678_abnormal_skin_adnexa0.57996582
127MP0004264_abnormal_extraembryonic_tissu0.56930073
128MP0003943_abnormal_hepatobiliary_system0.56487142
129MP0005332_abnormal_amino_acid0.56413984
130MP0000477_abnormal_intestine_morphology0.55999719
131MP0000371_diluted_coat_color0.55881142
132MP0002111_abnormal_tail_morphology0.55849835
133MP0001849_ear_inflammation0.55148860
134MP0009046_muscle_twitch0.55100276
135MP0009703_decreased_birth_body0.54961539
136MP0003705_abnormal_hypodermis_morpholog0.54002298
137MP0008875_abnormal_xenobiotic_pharmacok0.53392535
138MP0002092_abnormal_eye_morphology0.53368792
139MP0002254_reproductive_system_inflammat0.52991110
140MP0002075_abnormal_coat/hair_pigmentati0.52850942
141MP0005621_abnormal_cell_physiology0.52439001
142MP0001800_abnormal_humoral_immune0.52306135
143MP0003315_abnormal_perineum_morphology0.52276383
144MP0001764_abnormal_homeostasis0.52135727
145MP0003566_abnormal_cell_adhesion0.51690670
146MP0001188_hyperpigmentation0.50479616
147MP0002971_abnormal_brown_adipose0.48621068
148MP0002229_neurodegeneration0.47260894
149MP0005423_abnormal_somatic_nervous0.44841445
150MP0005499_abnormal_olfactory_system0.44592319
151MP0005394_taste/olfaction_phenotype0.44592319
152MP0009780_abnormal_chondrocyte_physiolo0.43119822
153MP0003329_amyloid_beta_deposits0.41791101
154MP0003638_abnormal_response/metabolism_0.41037407
155MP0006276_abnormal_autonomic_nervous0.40828719
156MP0001486_abnormal_startle_reflex0.40657046
157MP0002108_abnormal_muscle_morphology0.38950452
158MP0002233_abnormal_nose_morphology0.38417247
159MP0002067_abnormal_sensory_capabilities0.38179152

Predicted human phenotypes

RankGene SetZ-score
1Spontaneous abortion (HP:0005268)8.32568168
2Volvulus (HP:0002580)5.25305160
3Tubulointerstitial nephritis (HP:0001970)5.14218008
4Respiratory insufficiency due to defective ciliary clearance (HP:0200073)4.51798066
5Chromosomal breakage induced by crosslinking agents (HP:0003221)4.17895486
6Chromsome breakage (HP:0040012)4.16793503
7Carpal bone hypoplasia (HP:0001498)3.75520378
8Hypobetalipoproteinemia (HP:0003563)3.55743901
9Birth length less than 3rd percentile (HP:0003561)3.54630785
10Absent/shortened dynein arms (HP:0200106)3.46912671
11Dynein arm defect of respiratory motile cilia (HP:0012255)3.46912671
12Impulsivity (HP:0100710)3.46901422
13Abnormality of the ileum (HP:0001549)3.41713487
14Meckel diverticulum (HP:0002245)3.38898211
15Abnormality of chromosome stability (HP:0003220)3.37306247
16Ependymoma (HP:0002888)3.36753492
17Abnormal respiratory epithelium morphology (HP:0012253)3.35226477
18Abnormal respiratory motile cilium morphology (HP:0005938)3.35226477
19Horizontal nystagmus (HP:0000666)3.31742425
20Selective tooth agenesis (HP:0001592)3.28258223
21Degeneration of anterior horn cells (HP:0002398)3.27340044
22Abnormality of the anterior horn cell (HP:0006802)3.27340044
23Nephronophthisis (HP:0000090)3.25434886
24Aplasia/Hypoplasia involving the carpal bones (HP:0006502)3.23239624
25Aplasia/Hypoplasia of the uvula (HP:0010293)3.21771507
26Abnormality of the lower motor neuron (HP:0002366)3.20769332
27Premature ovarian failure (HP:0008209)3.19367901
28Gonadotropin excess (HP:0000837)3.15735693
29Abnormality of the preputium (HP:0100587)3.13643298
30Rhinitis (HP:0012384)3.12009078
31Abnormal spermatogenesis (HP:0008669)3.07253359
32Resting tremor (HP:0002322)3.07057291
33Chronic hepatic failure (HP:0100626)3.03856217
34Thyroid-stimulating hormone excess (HP:0002925)3.02798080
35Breast hypoplasia (HP:0003187)3.02330745
36Supernumerary spleens (HP:0009799)2.98770376
37Abnormality of pyrimidine metabolism (HP:0004353)2.97730400
38Abnormality of the renal medulla (HP:0100957)2.96922462
39Agnosia (HP:0010524)2.94017800
40Hypolipoproteinemia (HP:0010981)2.92400978
41Medulloblastoma (HP:0002885)2.89355691
42Abnormality of DNA repair (HP:0003254)2.86086451
43Hyperkalemia (HP:0002153)2.85579186
44Rectal fistula (HP:0100590)2.82135964
45Rectovaginal fistula (HP:0000143)2.82135964
46Facial hemangioma (HP:0000329)2.81918998
47Absent radius (HP:0003974)2.80927622
48Severe visual impairment (HP:0001141)2.80758450
49Rhabdomyosarcoma (HP:0002859)2.80311025
50Absent thumb (HP:0009777)2.77080848
51Azoospermia (HP:0000027)2.76616500
52Truncal obesity (HP:0001956)2.74493695
53Retinal atrophy (HP:0001105)2.74085352
54Abnormality of the renal collecting system (HP:0004742)2.73689863
55Oligodactyly (hands) (HP:0001180)2.72033928
56Aplasia/hypoplasia of the humerus (HP:0006507)2.69901021
57Osteomalacia (HP:0002749)2.68885882
58Abnormal respiratory motile cilium physiology (HP:0012261)2.68647863
59Molar tooth sign on MRI (HP:0002419)2.67138336
60Abnormality of midbrain morphology (HP:0002418)2.67138336
61Rough bone trabeculation (HP:0100670)2.64125771
62Nasal polyposis (HP:0100582)2.63857556
63Rib fusion (HP:0000902)2.61900978
64Bile duct proliferation (HP:0001408)2.61514109
65Abnormal biliary tract physiology (HP:0012439)2.61514109
66Myelodysplasia (HP:0002863)2.60672965
67Aplasia involving forearm bones (HP:0009822)2.59730447
68Absent forearm bone (HP:0003953)2.59730447
69Metaphyseal cupping (HP:0003021)2.57736040
70Cerebellar dysplasia (HP:0007033)2.57583158
71Patellar aplasia (HP:0006443)2.57102752
72Abnormality of the carotid arteries (HP:0005344)2.56537451
73Aplastic anemia (HP:0001915)2.56437512
74Bone marrow hypocellularity (HP:0005528)2.54195980
75Neoplasm of the oral cavity (HP:0100649)2.52642876
76Oral leukoplakia (HP:0002745)2.52589864
77Chronic bronchitis (HP:0004469)2.50620869
78Bell-shaped thorax (HP:0001591)2.50501631
79Short nail (HP:0001799)2.48893486
80Duodenal stenosis (HP:0100867)2.48041433
81Small intestinal stenosis (HP:0012848)2.48041433
82Cerebral hypomyelination (HP:0006808)2.44573142
83Vaginal fistula (HP:0004320)2.43613854
84Basal cell carcinoma (HP:0002671)2.42634676
85Abnormality of the aortic arch (HP:0012303)2.41033731
86Tubulointerstitial abnormality (HP:0001969)2.38828845
87Secondary amenorrhea (HP:0000869)2.37793648
8811 pairs of ribs (HP:0000878)2.37683476
89Abnormal protein glycosylation (HP:0012346)2.37655333
90Abnormal glycosylation (HP:0012345)2.37655333
91Abnormal isoelectric focusing of serum transferrin (HP:0003160)2.37655333
92Abnormal protein N-linked glycosylation (HP:0012347)2.37655333
93Intestinal fistula (HP:0100819)2.37575901
94Broad distal phalanx of finger (HP:0009836)2.37155259
95Abnormality of the labia minora (HP:0012880)2.35820541
96Multiple enchondromatosis (HP:0005701)2.35650720
97Short humerus (HP:0005792)2.33844116
98Aplasia/Hypoplasia of the patella (HP:0006498)2.31971573
99Atrophy/Degeneration involving motor neurons (HP:0007373)2.31556489
100Hypoalphalipoproteinemia (HP:0003233)2.29894673
101Spinal muscular atrophy (HP:0007269)2.29865477
102Tracheoesophageal fistula (HP:0002575)2.29315965
103Neoplasm of striated muscle (HP:0009728)2.29150271
104Amyotrophic lateral sclerosis (HP:0007354)2.28944667
105Sloping forehead (HP:0000340)2.28758017
106Hypochromic microcytic anemia (HP:0004840)2.28531620
107Nephroblastoma (Wilms tumor) (HP:0002667)2.28244438
108Hyperpituitarism (HP:0010514)2.28136034
109Reticulocytopenia (HP:0001896)2.26966379
110Type I transferrin isoform profile (HP:0003642)2.26542199
111Infertility (HP:0000789)2.25435334
112Abnormality of pyruvate family amino acid metabolism (HP:0010915)2.25353135
113Abnormality of alanine metabolism (HP:0010916)2.25353135
114Hyperalaninemia (HP:0003348)2.25353135
115Prolonged partial thromboplastin time (HP:0003645)2.25043107
116Tongue fasciculations (HP:0001308)2.22339012
117Ectopic kidney (HP:0000086)2.22308609
118Abnormal ciliary motility (HP:0012262)2.22176890
119Abnormality of the level of lipoprotein cholesterol (HP:0010979)2.20364071
120Increased nuchal translucency (HP:0010880)2.17951149
121Missing ribs (HP:0000921)2.16913755
122Intestinal atresia (HP:0011100)2.16782962
123Abnormality of the astrocytes (HP:0100707)2.16280198
124Astrocytoma (HP:0009592)2.16280198
125Aplasia/Hypoplasia of the sternum (HP:0006714)2.16144290
126Colon cancer (HP:0003003)2.15174188
127Male infertility (HP:0003251)2.12925922
128Abnormality of lateral ventricle (HP:0030047)2.12151957
129Bony spicule pigmentary retinopathy (HP:0007737)2.11427052
130Cystic liver disease (HP:0006706)2.10755190
131Degeneration of the lateral corticospinal tracts (HP:0002314)2.10319289
132Atrophy/Degeneration involving the corticospinal tracts (HP:0007372)2.10319289
133Short thumb (HP:0009778)2.10096558
134Duplicated collecting system (HP:0000081)2.09698985
135Squamous cell carcinoma (HP:0002860)2.09199541
136Type II lissencephaly (HP:0007260)2.08757008
137Lip pit (HP:0100267)2.08462659
138Clubbing of toes (HP:0100760)2.07856987
139Abnormality of abdominal situs (HP:0011620)2.07725217
140Abdominal situs inversus (HP:0003363)2.07725217
141Upper motor neuron abnormality (HP:0002127)2.06666702
142Amaurosis fugax (HP:0100576)2.06367245
143Abnormal trabecular bone morphology (HP:0100671)2.05435318
144Attenuation of retinal blood vessels (HP:0007843)2.03211015
145Bifid tongue (HP:0010297)2.03165658
146Non-midline cleft lip (HP:0100335)2.02842106
147Premature graying of hair (HP:0002216)2.02140365
148Embryonal renal neoplasm (HP:0011794)2.01678343
149Abnormal delivery (HP:0001787)1.99363674
150Shoulder girdle muscle weakness (HP:0003547)1.99309150
151Tubular atrophy (HP:0000092)1.98799251
152Scotoma (HP:0000575)1.94815839
153Abnormality of the duodenum (HP:0002246)1.94349467
154Abnormal lung lobation (HP:0002101)1.92511506
155Hypoplastic iliac wings (HP:0002866)1.92408302
156Large hands (HP:0001176)1.91434290
157Personality changes (HP:0000751)1.91248099
158Glioma (HP:0009733)1.90546099
159Abnormality of the nasal mucosa (HP:0000433)1.90116752
160Thickened helices (HP:0000391)1.88936516
161Muscle fibrillation (HP:0010546)1.88921826
162Broad alveolar ridges (HP:0000187)1.88439420
163Parkinsonism with favorable response to dopaminergic medication (HP:0002548)1.86981711
164Impaired vibration sensation in the lower limbs (HP:0002166)1.84864494
165Postural instability (HP:0002172)1.83239971
166Abnormality of macular pigmentation (HP:0008002)1.78927162
167Stage 5 chronic kidney disease (HP:0003774)1.75387401

Predicted kinase interactions (KEA)

RankGene SetZ-score
1CDK194.37575642
2WEE14.32329104
3PDK44.02618584
4PDK34.02618584
5CDK123.62768235
6CDC73.59844087
7MET3.41883424
8EIF2AK13.33622359
9BUB13.31497906
10ADRBK22.86921688
11NEK22.81035423
12OXSR12.79738434
13PLK22.74922186
14PTK2B2.73530898
15TTK2.71593284
16PDK22.57019384
17CAMK1G2.52975821
18FRK2.40991919
19ACVR1B2.16787757
20SRPK12.16558621
21PLK12.14193991
22BMX2.06445865
23CDK72.04259581
24FGR1.83755929
25CHEK21.72889200
26PLK41.72147673
27NEK91.69535337
28ATR1.69231533
29NEK11.68183376
30ICK1.61904151
31EIF2AK31.49887313
32IRAK31.48024314
33EPHA21.44082585
34MST1R1.43878420
35TESK21.38720043
36CDK41.37409935
37BRSK21.37369052
38SCYL21.32097602
39RPS6KB21.31203296
40CHEK11.29754275
41DYRK31.26319729
42STK101.18986254
43MAP3K21.15573509
44AURKB1.12289880
45AURKA1.11950688
46AKT31.10617898
47PIK3CG1.06008554
48PINK11.05208848
49MAP4K11.05146408
50TYRO31.05033396
51STK391.03943609
52BRD41.03493929
53CASK1.00567864
54MAP3K61.00141085
55PDK10.97926642
56TESK10.97467687
57PASK0.96994449
58MAP4K20.96786727
59MARK30.96719047
60PDPK10.96553902
61FGFR20.95808984
62MATK0.95686129
63STK160.95541084
64FLT30.95494330
65PAK40.95345186
66ATM0.94827468
67PIM10.94340626
68WNK40.94107032
69VRK10.89590199
70PNCK0.89146902
71INSRR0.88869494
72MAP3K80.88296389
73ALK0.84443369
74CDK20.83929666
75PLK30.83802749
76ZAP700.83290777
77NME20.80631603
78PBK0.78948502
79STK40.77168803
80MKNK20.77090643
81ADRBK10.75992388
82STK38L0.74747872
83STK30.73065424
84RET0.72984356
85BMPR1B0.71897082
86TSSK60.69223188
87BLK0.68684450
88EEF2K0.67205250
89PDGFRB0.67099666
90MKNK10.65896280
91YES10.64882636
92CSF1R0.64220698
93CDK60.62530253
94MELK0.62425818
95MUSK0.61038845
96PRKCG0.59385844
97EPHA40.59170944
98CCNB10.58008663
99CDK10.57741060
100BRSK10.57554593
101MAP2K20.57066936
102MAP3K40.56518828
103LATS20.56152871
104NTRK30.54627965
105PRKCE0.54613756
106PRKCI0.54169733
107MTOR0.54160075
108CSNK2A20.54081109
109CSNK2A10.53369114
110NEK60.52909216
111SGK10.52682712
112TNIK0.51891593
113GRK60.51814736
114MAPKAPK30.51781699
115PAK10.51485878
116BRAF0.51331650
117CDK30.51165350
118EIF2AK20.51020878
119BCKDK0.50887001
120FGFR30.50644569
121TXK0.49407403
122EGFR0.47528760
123MAPK110.44988353
124DYRK1A0.43415919
125DDR20.42991667
126PRKG10.42316407
127KSR20.39471036
128ROCK10.38875001
129MAP3K110.38002556
130ZAK0.37841096
131CAMK10.37261094
132PRKDC0.34814754
133CSNK1E0.34192667
134PRKACB0.33928382
135ERN10.33420020
136STK110.33088204
137TEC0.32598570
138PTK20.32505124
139PRKCZ0.30802908
140NLK0.28823888
141WNK30.28779773
142LATS10.28552623
143TAOK10.27498570
144CSK0.25247776
145MAPK140.24963138
146TYK20.24951128
147TLK10.24780630
148RPS6KA40.24737366
149MAP3K100.24289285
150GRK10.24271534
151STK380.24056804
152IGF1R0.23677062
153MAPK10.22862359
154RPS6KB10.22271420
155GSK3B0.22199117
156PIM20.22178474
157ARAF0.21589241
158DAPK10.19980755
159CSNK1D0.19283550
160MAP3K90.18937351

Predicted pathways (KEGG)

RankGene SetZ-score
1DNA replication_Homo sapiens_hsa030304.51512082
2Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030084.18502506
3Mismatch repair_Homo sapiens_hsa034304.09929941
4Homologous recombination_Homo sapiens_hsa034403.59536101
5RNA transport_Homo sapiens_hsa030133.38237560
6Primary bile acid biosynthesis_Homo sapiens_hsa001203.08583970
7Base excision repair_Homo sapiens_hsa034102.95069656
8Fanconi anemia pathway_Homo sapiens_hsa034602.94186180
9RNA polymerase_Homo sapiens_hsa030202.83304753
10Retinol metabolism_Homo sapiens_hsa008302.71440369
11Spliceosome_Homo sapiens_hsa030402.69545015
12Proteasome_Homo sapiens_hsa030502.69288503
13Synthesis and degradation of ketone bodies_Homo sapiens_hsa000722.65620868
14Nucleotide excision repair_Homo sapiens_hsa034202.57103760
15Propanoate metabolism_Homo sapiens_hsa006402.55405919
16Basal transcription factors_Homo sapiens_hsa030222.48738905
17Cell cycle_Homo sapiens_hsa041102.43870899
18Butanoate metabolism_Homo sapiens_hsa006502.34900163
19Steroid hormone biosynthesis_Homo sapiens_hsa001402.32152385
20One carbon pool by folate_Homo sapiens_hsa006702.30126955
21Vitamin B6 metabolism_Homo sapiens_hsa007502.29739296
22Pyrimidine metabolism_Homo sapiens_hsa002402.24015785
23Ribosome_Homo sapiens_hsa030102.23118267
24Fatty acid degradation_Homo sapiens_hsa000712.22650239
25Ascorbate and aldarate metabolism_Homo sapiens_hsa000532.22248378
26Caffeine metabolism_Homo sapiens_hsa002322.22127566
27Drug metabolism - cytochrome P450_Homo sapiens_hsa009822.20317111
28Non-homologous end-joining_Homo sapiens_hsa034502.06905490
29Fat digestion and absorption_Homo sapiens_hsa049752.01525698
30Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa009702.00450308
31Vitamin digestion and absorption_Homo sapiens_hsa049771.94276543
32Valine, leucine and isoleucine degradation_Homo sapiens_hsa002801.89419081
33mRNA surveillance pathway_Homo sapiens_hsa030151.81508637
34RNA degradation_Homo sapiens_hsa030181.79230444
35Pentose phosphate pathway_Homo sapiens_hsa000301.72564522
36beta-Alanine metabolism_Homo sapiens_hsa004101.60985728
37Phenylalanine metabolism_Homo sapiens_hsa003601.59784924
38p53 signaling pathway_Homo sapiens_hsa041151.56069334
39Nitrogen metabolism_Homo sapiens_hsa009101.55658208
40PPAR signaling pathway_Homo sapiens_hsa033201.51751679
41Selenocompound metabolism_Homo sapiens_hsa004501.46418031
42Olfactory transduction_Homo sapiens_hsa047401.42211335
43Biosynthesis of amino acids_Homo sapiens_hsa012301.29762088
44Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa005201.27019787
45Fatty acid metabolism_Homo sapiens_hsa012121.26008376
46Tryptophan metabolism_Homo sapiens_hsa003801.24231570
47Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001301.21918752
48Purine metabolism_Homo sapiens_hsa002301.19607353
49ABC transporters_Homo sapiens_hsa020101.18266129
50Ubiquitin mediated proteolysis_Homo sapiens_hsa041201.17911361
51Cysteine and methionine metabolism_Homo sapiens_hsa002701.17328573
52Phototransduction_Homo sapiens_hsa047441.15380255
53Fructose and mannose metabolism_Homo sapiens_hsa000511.06178403
54Oocyte meiosis_Homo sapiens_hsa041141.04540134
55Peroxisome_Homo sapiens_hsa041461.03518792
56Folate biosynthesis_Homo sapiens_hsa007900.99629552
57Epstein-Barr virus infection_Homo sapiens_hsa051690.96866799
58Fatty acid biosynthesis_Homo sapiens_hsa000610.95231720
59Arginine biosynthesis_Homo sapiens_hsa002200.94932958
60Herpes simplex infection_Homo sapiens_hsa051680.89617889
61Antigen processing and presentation_Homo sapiens_hsa046120.87678341
62Cytosolic DNA-sensing pathway_Homo sapiens_hsa046230.86020209
63Taurine and hypotaurine metabolism_Homo sapiens_hsa004300.84093146
64Regulation of autophagy_Homo sapiens_hsa041400.81615961
65Ether lipid metabolism_Homo sapiens_hsa005650.80411125
66Legionellosis_Homo sapiens_hsa051340.80064355
67Glycolysis / Gluconeogenesis_Homo sapiens_hsa000100.79597733
68N-Glycan biosynthesis_Homo sapiens_hsa005100.79021130
69Carbon metabolism_Homo sapiens_hsa012000.78011534
70Glutathione metabolism_Homo sapiens_hsa004800.75523255
71Sphingolipid metabolism_Homo sapiens_hsa006000.72876011
72Tyrosine metabolism_Homo sapiens_hsa003500.72147404
73Histidine metabolism_Homo sapiens_hsa003400.71731553
74Glycine, serine and threonine metabolism_Homo sapiens_hsa002600.71095568
75Taste transduction_Homo sapiens_hsa047420.70021491
76Sulfur relay system_Homo sapiens_hsa041220.69781802
77Starch and sucrose metabolism_Homo sapiens_hsa005000.66510647
78Primary immunodeficiency_Homo sapiens_hsa053400.64804267
79Viral carcinogenesis_Homo sapiens_hsa052030.64260153
80alpha-Linolenic acid metabolism_Homo sapiens_hsa005920.63333000
81Linoleic acid metabolism_Homo sapiens_hsa005910.60768523
82Cyanoamino acid metabolism_Homo sapiens_hsa004600.58624727
83Systemic lupus erythematosus_Homo sapiens_hsa053220.57675034
84Progesterone-mediated oocyte maturation_Homo sapiens_hsa049140.57637676
85Bile secretion_Homo sapiens_hsa049760.56771690
86Drug metabolism - other enzymes_Homo sapiens_hsa009830.54824077
87Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007600.51588152
88Staphylococcus aureus infection_Homo sapiens_hsa051500.51276635
892-Oxocarboxylic acid metabolism_Homo sapiens_hsa012100.50842653
90Neuroactive ligand-receptor interaction_Homo sapiens_hsa040800.50523499
91HTLV-I infection_Homo sapiens_hsa051660.48029485
92Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006300.47446788
93Terpenoid backbone biosynthesis_Homo sapiens_hsa009000.46886014
94Maturity onset diabetes of the young_Homo sapiens_hsa049500.46859500
95Pyruvate metabolism_Homo sapiens_hsa006200.45467406
96Glucagon signaling pathway_Homo sapiens_hsa049220.42067978
97Calcium signaling pathway_Homo sapiens_hsa040200.39302021
98Hedgehog signaling pathway_Homo sapiens_hsa043400.39284088
99Arachidonic acid metabolism_Homo sapiens_hsa005900.38875610
100Arginine and proline metabolism_Homo sapiens_hsa003300.38557970
101Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa045500.37808449
102Thyroid cancer_Homo sapiens_hsa052160.37555739
103Longevity regulating pathway - multiple species_Homo sapiens_hsa042130.36998388
104Pantothenate and CoA biosynthesis_Homo sapiens_hsa007700.35219264
105Galactose metabolism_Homo sapiens_hsa000520.34693464
106Transcriptional misregulation in cancer_Homo sapiens_hsa052020.34625779
107Glycerophospholipid metabolism_Homo sapiens_hsa005640.34308140
108Huntingtons disease_Homo sapiens_hsa050160.34082248
109Butirosin and neomycin biosynthesis_Homo sapiens_hsa005240.33932124
110Metabolic pathways_Homo sapiens_hsa011000.33595064
111Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005630.33167499
112Pentose and glucuronate interconversions_Homo sapiens_hsa000400.30837448
113Protein processing in endoplasmic reticulum_Homo sapiens_hsa041410.30565317
114NF-kappa B signaling pathway_Homo sapiens_hsa040640.29995964
115Citrate cycle (TCA cycle)_Homo sapiens_hsa000200.26072135
116Apoptosis_Homo sapiens_hsa042100.25342342
117Measles_Homo sapiens_hsa051620.24927135
118Intestinal immune network for IgA production_Homo sapiens_hsa046720.24439797
119African trypanosomiasis_Homo sapiens_hsa051430.23850789
120mTOR signaling pathway_Homo sapiens_hsa041500.23274639
121Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004000.23209955
122Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009800.22715757
123Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002500.22593666
124Glycerolipid metabolism_Homo sapiens_hsa005610.21427034
125Protein digestion and absorption_Homo sapiens_hsa049740.20908713
126Hematopoietic cell lineage_Homo sapiens_hsa046400.20649239
127MicroRNAs in cancer_Homo sapiens_hsa052060.19731849
128Mineral absorption_Homo sapiens_hsa049780.19690636
129Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049640.19459941
130TGF-beta signaling pathway_Homo sapiens_hsa043500.18838248
131NOD-like receptor signaling pathway_Homo sapiens_hsa046210.18793091
132Ovarian steroidogenesis_Homo sapiens_hsa049130.18014319
133Notch signaling pathway_Homo sapiens_hsa043300.17716595
134Small cell lung cancer_Homo sapiens_hsa052220.15055460
135Lysine degradation_Homo sapiens_hsa003100.14469270
136Dorso-ventral axis formation_Homo sapiens_hsa043200.12999405
137Central carbon metabolism in cancer_Homo sapiens_hsa052300.12891972
138Asthma_Homo sapiens_hsa053100.12493595
139Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008600.12250885
140Influenza A_Homo sapiens_hsa051640.11815655
141Jak-STAT signaling pathway_Homo sapiens_hsa046300.11487490
142Chemical carcinogenesis_Homo sapiens_hsa052040.11135334
143Renin-angiotensin system_Homo sapiens_hsa046140.10851023
144Complement and coagulation cascades_Homo sapiens_hsa046100.10011859
145Amyotrophic lateral sclerosis (ALS)_Homo sapiens_hsa050140.09137689
146Acute myeloid leukemia_Homo sapiens_hsa052210.08999369
147Inflammatory bowel disease (IBD)_Homo sapiens_hsa053210.08755253
148Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005330.08620484

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