HOXA10

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: In vertebrates, the genes encoding the class of transcription factors called homeobox genes are found in clusters named A, B, C, and D on four separate chromosomes. Expression of these proteins is spatially and temporally regulated during embryonic development. This gene is part of the A cluster on chromosome 7 and encodes a DNA-binding transcription factor that may regulate gene expression, morphogenesis, and differentiation. More specifically, it may function in fertility, embryo viability, and regulation of hematopoietic lineage commitment. Alternatively spliced transcript variants have been described. Read-through transcription also exists between this gene and the downstream homeobox A9 (HOXA9) gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1positive regulation of type I interferon-mediated signaling pathway (GO:0060340)7.42737020
2embryonic skeletal joint morphogenesis (GO:0060272)6.64262682
3cellular response to virus (GO:0098586)6.51334168
4regulation of interferon-beta biosynthetic process (GO:0045357)6.31154774
5* proximal/distal pattern formation (GO:0009954)5.49816222
6chondrocyte proliferation (GO:0035988)5.42289365
7glomerular basement membrane development (GO:0032836)5.27645069
8metanephric mesenchyme development (GO:0072075)5.23169476
9mesenchymal to epithelial transition involved in metanephros morphogenesis (GO:0003337)5.22666528
10organ induction (GO:0001759)5.14314913
11cartilage development involved in endochondral bone morphogenesis (GO:0060351)5.13017082
12kidney mesenchyme development (GO:0072074)4.98834387
13muscle filament sliding (GO:0030049)4.92444912
14actin-myosin filament sliding (GO:0033275)4.92444912
15thyroid gland development (GO:0030878)4.75689529
16regulation of apoptotic process involved in morphogenesis (GO:1902337)4.72131528
17deoxyribonucleoside monophosphate metabolic process (GO:0009162)4.65867569
18positive regulation of chondrocyte differentiation (GO:0032332)4.62847859
19ribosomal small subunit biogenesis (GO:0042274)4.55978472
20regulation of skeletal muscle contraction (GO:0014819)4.55768828
21proline biosynthetic process (GO:0006561)4.50440885
22glomerular filtration (GO:0003094)4.48150941
23renal filtration (GO:0097205)4.21842157
24positive regulation of cartilage development (GO:0061036)4.21723386
25fucose catabolic process (GO:0019317)4.21257817
26L-fucose metabolic process (GO:0042354)4.21257817
27L-fucose catabolic process (GO:0042355)4.21257817
28outer ear morphogenesis (GO:0042473)4.21168243
29cellular response to dsRNA (GO:0071359)4.17693215
30aminoglycoside antibiotic metabolic process (GO:0030647)4.11283259
31regulation of single stranded viral RNA replication via double stranded DNA intermediate (GO:00450914.09605027
32actin-mediated cell contraction (GO:0070252)4.09142778
33AMP metabolic process (GO:0046033)4.07883205
34* uterus development (GO:0060065)4.03412901
35embryonic forelimb morphogenesis (GO:0035115)3.97655981
36muscle cell fate commitment (GO:0042693)3.94856668
37regulation of organ formation (GO:0003156)3.94479009
38glomerular visceral epithelial cell development (GO:0072015)3.90817536
39forelimb morphogenesis (GO:0035136)3.89433355
40lymph vessel development (GO:0001945)3.88535626
41leukocyte apoptotic process (GO:0071887)3.88430113
42cGMP-mediated signaling (GO:0019934)3.86082645
43skeletal muscle contraction (GO:0003009)3.85983852
44negative regulation of epidermis development (GO:0045683)3.84512331
45mesenchymal to epithelial transition (GO:0060231)3.84162411
46metanephros development (GO:0001656)3.82194553
47embryonic skeletal system morphogenesis (GO:0048704)3.81348438
48macroautophagy (GO:0016236)3.80131805
49pyrimidine deoxyribonucleotide catabolic process (GO:0009223)3.78790635
50positive regulation of actin cytoskeleton reorganization (GO:2000251)3.64264924
51mesonephros development (GO:0001823)3.61216092
52positive regulation of metanephros development (GO:0072216)3.60982779
53negative regulation of mRNA splicing, via spliceosome (GO:0048025)3.60016103
54middle ear morphogenesis (GO:0042474)3.47320883
55definitive hemopoiesis (GO:0060216)3.47126153
56negative regulation of metanephros development (GO:0072217)3.45220289
57regulation of mesenchymal cell apoptotic process (GO:2001053)3.43488504
58branching involved in ureteric bud morphogenesis (GO:0001658)3.42865365
59cytokine biosynthetic process (GO:0042089)3.42760255
60actin filament depolymerization (GO:0030042)3.40704488
61fucose metabolic process (GO:0006004)3.40449879
62maturation of SSU-rRNA (GO:0030490)3.40327605
63regulation of hair follicle development (GO:0051797)3.39362093
64creatine metabolic process (GO:0006600)3.38826797
65cranial nerve morphogenesis (GO:0021602)3.38345991
66flavonoid metabolic process (GO:0009812)3.37912763
67nucleotide salvage (GO:0043173)3.37054158
68polyketide metabolic process (GO:0030638)3.33782391
69doxorubicin metabolic process (GO:0044598)3.33782391
70daunorubicin metabolic process (GO:0044597)3.33782391
71protein targeting to Golgi (GO:0000042)3.32671233
72purine nucleotide salvage (GO:0032261)3.29919532
73glomerular epithelial cell development (GO:0072310)3.26637844
74ribosomal small subunit assembly (GO:0000028)3.23378649
75negative regulation of cell size (GO:0045792)3.22288199
76negative regulation of viral entry into host cell (GO:0046597)3.21566387
77negative regulation of mRNA processing (GO:0050686)3.21331293
78response to pheromone (GO:0019236)3.19654239
79mitotic chromosome condensation (GO:0007076)3.19511917
80regulation of branching involved in prostate gland morphogenesis (GO:0060687)3.19434600
81skeletal system morphogenesis (GO:0048705)3.18144620
82UV protection (GO:0009650)3.17339954
83purine nucleobase metabolic process (GO:0006144)3.16964656
84cell proliferation involved in metanephros development (GO:0072203)3.16169985
85retrograde transport, vesicle recycling within Golgi (GO:0000301)3.15511887
86purine ribonucleotide transport (GO:0015868)3.14058736
87viral transcription (GO:0019083)3.13804357
88response to muscle activity (GO:0014850)3.13469021
89positive regulation of interferon-alpha production (GO:0032727)3.12364887
90muscle organ morphogenesis (GO:0048644)3.08330614
91type B pancreatic cell proliferation (GO:0044342)3.07881308
92positive regulation of myotube differentiation (GO:0010831)3.07307428
93DNA unwinding involved in DNA replication (GO:0006268)3.06470090
94establishment of protein localization to Golgi (GO:0072600)3.05804702
95organic cation transport (GO:0015695)3.05177274
96oxidative phosphorylation (GO:0006119)3.04946705
97translational termination (GO:0006415)3.04908177
98negative regulation of defense response to virus (GO:0050687)3.04430249
99programmed necrotic cell death (GO:0097300)3.03436366
100nucleobase-containing small molecule interconversion (GO:0015949)3.02601729
101glucan biosynthetic process (GO:0009250)3.02317395
102glycogen biosynthetic process (GO:0005978)3.02317395
103ubiquinone biosynthetic process (GO:0006744)3.02131585
104regulation of mammary gland epithelial cell proliferation (GO:0033599)3.01937111
105pyrimidine nucleotide catabolic process (GO:0006244)2.98931779
106NADH metabolic process (GO:0006734)2.98685084
107ribosomal large subunit biogenesis (GO:0042273)2.97928678
108urate metabolic process (GO:0046415)2.97135416
109formation of translation preinitiation complex (GO:0001731)2.95996338
110regulation of chondrocyte differentiation (GO:0032330)2.95930104
111ribonucleoprotein complex biogenesis (GO:0022613)2.94079384
112ribosome assembly (GO:0042255)2.92936176
113regulation of defense response to virus by host (GO:0050691)2.90639268
114negative regulation of erythrocyte differentiation (GO:0045647)2.90592913
115mature B cell differentiation involved in immune response (GO:0002313)2.89188676
116pyrimidine deoxyribonucleotide metabolic process (GO:0009219)2.89139674
117DNA strand elongation involved in DNA replication (GO:0006271)2.88285422
118negative regulation of mesenchymal cell apoptotic process (GO:2001054)2.88210389
119carnitine transmembrane transport (GO:1902603)2.87025375
120adenine nucleotide transport (GO:0051503)2.85993535
121translational elongation (GO:0006414)2.85776200
122fucosylation (GO:0036065)2.85671812
123regulation of interferon-alpha production (GO:0032647)2.85445728
124negative regulation of B cell apoptotic process (GO:0002903)2.85150218
125regulation of mesenchymal to epithelial transition involved in metanephros morphogenesis (GO:00033392.85098498
126skeletal muscle tissue development (GO:0007519)2.84652742
127DNA strand elongation (GO:0022616)2.83966438
128negative regulation of vascular endothelial growth factor receptor signaling pathway (GO:0030948)2.83263271
129branching involved in prostate gland morphogenesis (GO:0060442)2.81258391
130cell migration involved in heart development (GO:0060973)2.81082208
131myofibril assembly (GO:0030239)2.81038767
132developmental induction (GO:0031128)2.80471292
133regulation of metanephros development (GO:0072215)2.79527365
134IMP metabolic process (GO:0046040)2.79498228
135negative regulation of cell cycle G2/M phase transition (GO:1902750)2.78291802
136negative regulation of necroptotic process (GO:0060546)2.78058818
137negative regulation of RNA splicing (GO:0033119)2.76764792
138grooming behavior (GO:0007625)2.76201809
139metanephric epithelium development (GO:0072207)2.75649126
140bone trabecula formation (GO:0060346)2.74854635
141skeletal muscle fiber development (GO:0048741)2.74123448
142embryonic organ morphogenesis (GO:0048562)2.73197138
143drug transmembrane transport (GO:0006855)2.72873192
144pyrimidine nucleoside triphosphate metabolic process (GO:0009147)2.72252652
145smooth muscle tissue development (GO:0048745)2.72175679
146mesenchymal-epithelial cell signaling (GO:0060638)2.71921690
147regulation of stem cell maintenance (GO:2000036)2.71833683
148cell-cell signaling involved in cell fate commitment (GO:0045168)2.71699103
149collagen fibril organization (GO:0030199)2.71283609
150necrotic cell death (GO:0070265)2.71244739
151nephron tubule formation (GO:0072079)2.71197984
152poly(A)+ mRNA export from nucleus (GO:0016973)2.69899966
153primitive streak formation (GO:0090009)2.68253537
154actin filament-based movement (GO:0030048)2.68183035
155peripheral nervous system neuron development (GO:0048935)2.67993891
156glycogen catabolic process (GO:0005980)2.67792882
157telomere maintenance via semi-conservative replication (GO:0032201)2.67671391
158folic acid metabolic process (GO:0046655)2.66492300
159vitamin A metabolic process (GO:0006776)2.66322313
160cytokine metabolic process (GO:0042107)2.66032727
161regulation of cartilage development (GO:0061035)2.65076652
162purine-containing compound salvage (GO:0043101)2.64215148
163regulation of mitochondrial translation (GO:0070129)2.63872896
164pseudouridine synthesis (GO:0001522)2.63146564
165carnitine shuttle (GO:0006853)2.60915144
166diterpenoid biosynthetic process (GO:0016102)2.60770567
167negative regulation of mRNA metabolic process (GO:1903312)2.60700515
168regulation of actin cytoskeleton reorganization (GO:2000249)2.60387044
169regulation of glomerulus development (GO:0090192)2.60090478
170diaphragm development (GO:0060539)2.59685037
171DNA replication initiation (GO:0006270)2.59561854
172sarcoplasmic reticulum calcium ion transport (GO:0070296)2.58998004
173negative regulation of skeletal muscle tissue development (GO:0048642)2.58909283
174quinone biosynthetic process (GO:1901663)2.57675359
175nuclear-transcribed mRNA catabolic process, nonsense-mediated decay (GO:0000184)2.56380490
176sarcomere organization (GO:0045214)2.52962257
177carnitine transport (GO:0015879)2.51295447
178amino-acid betaine transport (GO:0015838)2.51295447
179regulation of necrotic cell death (GO:0010939)2.50688997
180proline metabolic process (GO:0006560)2.50525121
181pyrimidine nucleoside monophosphate metabolic process (GO:0009129)2.48143260
182dosage compensation (GO:0007549)2.48037217
183DNA synthesis involved in DNA repair (GO:0000731)2.47822275
184glucan catabolic process (GO:0009251)2.46235487
185nucleoside diphosphate biosynthetic process (GO:0009133)2.45004862
186glycogen metabolic process (GO:0005977)2.44260728
187ribosome biogenesis (GO:0042254)2.44181968

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1SRY_22984422_ChIP-ChIP_TESTIS_Rat3.50563207
2TP63_19390658_ChIP-ChIP_HaCaT_Human3.41539154
3* CHD7_19251738_ChIP-ChIP_MESCs_Mouse3.21666453
4* RARG_19884340_ChIP-ChIP_MEFs_Mouse3.09838288
5E2F7_22180533_ChIP-Seq_HELA_Human3.07605700
6KLF2_18264089_ChIP-ChIP_MESCs_Mouse3.06647107
7KLF5_18264089_ChIP-ChIP_MESCs_Mouse3.06647107
8KLF4_18264089_ChIP-ChIP_MESCs_Mouse3.06647107
9CDX2_20551321_ChIP-Seq_CACO-2_Human2.92957989
10HCFC1_20581084_ChIP-Seq_MESCs_Mouse2.88716289
11BP1_19119308_ChIP-ChIP_Hs578T_Human2.63432361
12MYC_18358816_ChIP-ChIP_MESCs_Mouse2.61155280
13NANOG_18700969_ChIP-ChIP_MESCs_Mouse2.50864049
14TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat2.47140463
15JARID1A_20064375_ChIP-Seq_MESCs_Mouse2.44606140
16XRN2_22483619_ChIP-Seq_HELA_Human2.44011525
17HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse2.43752276
18EKLF_21900194_ChIP-Seq_ERYTHROCYTE_Mouse2.37720467
19* WT1_20215353_ChIP-ChIP_NEPHRON_PROGENITOR_Mouse2.33420509
20TCF3_18692474_ChIP-Seq_MEFs_Mouse2.21771660
21POU5F1_18700969_ChIP-ChIP_MESCs_Mouse2.21681674
22BCL3_23251550_ChIP-Seq_MUSCLE_Mouse2.21359811
23ELF1_17652178_ChIP-ChIP_JURKAT_Human2.19872760
24ZNF263_19887448_ChIP-Seq_K562_Human2.17077883
25* PHC1_16625203_ChIP-ChIP_MESCs_Mouse2.13678685
26IRF1_21803131_ChIP-Seq_MONOCYTES_Human2.09443828
27AR_21909140_ChIP-Seq_LNCAP_Human2.07678055
28PPARD_23176727_ChIP-Seq_KERATINOCYTES_Mouse2.07427540
29TAF7L_23326641_ChIP-Seq_C3H10T1-2_Mouse2.07196915
30ELK3_25401928_ChIP-Seq_HUVEC_Human2.06899428
31ETS1_20019798_ChIP-Seq_JURKAT_Human2.04816791
32STAT3_1855785_ChIP-Seq_MESCs_Mouse1.98211737
33THAP11_20581084_ChIP-Seq_MESCs_Mouse1.95256156
34TTF2_22483619_ChIP-Seq_HELA_Human1.91620786
35WT1_19549856_ChIP-ChIP_CCG9911_Human1.90006571
36MYC_18555785_ChIP-Seq_MESCs_Mouse1.87191762
37TRIM28_21343339_ChIP-Seq_HEK293_Human1.83855813
38EGR1_19374776_ChIP-ChIP_THP-1_Human1.83486342
39* TP53_20018659_ChIP-ChIP_R1E_Mouse1.82755324
40DCP1A_22483619_ChIP-Seq_HELA_Human1.82086648
41ZFP281_18358816_ChIP-ChIP_MESCs_Mouse1.75855739
42DACH1_20351289_ChIP-Seq_MDA-MB-231_Human1.72658640
43HIF1A_21447827_ChIP-Seq_MCF-7_Human1.71902164
44TP63_17297297_ChIP-ChIP_HaCaT_Human1.71166125
45ESR1_21235772_ChIP-Seq_MCF-7_Human1.66331134
46NOTCH1_17114293_ChIP-ChIP_T-ALL_Human1.64593481
47KLF4_18358816_ChIP-ChIP_MESCs_Mouse1.63324950
48RUNX2_24764292_ChIP-Seq_MC3T3_Mouse1.62569447
49RACK7_27058665_Chip-Seq_MCF-7_Human1.62559310
50CIITA_25753668_ChIP-Seq_RAJI_Human1.60456902
51VDR_24763502_ChIP-Seq_THP-1_Human1.59712124
52OCT4_18692474_ChIP-Seq_MEFs_Mouse1.59166533
53SCL_19346495_ChIP-Seq_HPC-7_Human1.59059475
54MYBL1_21750041_ChIP-ChIP_SPERMATOCYTES_Mouse1.58543285
55KDM5A_27292631_Chip-Seq_BREAST_Human1.55838688
56CREB1_15753290_ChIP-ChIP_HEK293T_Human1.54396826
57E2F1_18555785_ChIP-Seq_MESCs_Mouse1.53176764
58* TET1_21451524_ChIP-Seq_MESCs_Mouse1.49672679
59CNOT3_19339689_ChIP-ChIP_MESCs_Mouse1.49107537
60SOX2_20726797_ChIP-Seq_SW620_Human1.49092460
61SRF_21415370_ChIP-Seq_HL-1_Mouse1.48826049
62ETS2_20176728_ChIP-ChIP_TROPHOBLAST_STEM_CELLS_Mouse1.48072647
63KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human1.47238070
64GABP_19822575_ChIP-Seq_HepG2_Human1.43802938
65TRP63_18441228_ChIP-ChIP_KERATINOCYTES_Mouse1.43693341
66NELFA_20434984_ChIP-Seq_ESCs_Mouse1.42970880
67NCOR1_26117541_ChIP-Seq_K562_Human1.42564584
68CEBPB_24764292_ChIP-Seq_MC3T3_Mouse1.41736974
69TCF21_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human1.40387886
70E2F1_21310950_ChIP-Seq_MCF-7_Human1.40333180
71PRDM16_22522345_ChIP-ChIP_PALATE_MESENCHYMAL_Mouse1.40100251
72FOXM1_25889361_ChIP-Seq_OE33_AND_U2OS_Human1.38859256
73ESR1_20079471_ChIP-ChIP_T-47D_Human1.35549449
74* KLF4_19030024_ChIP-ChIP_MESCs_Mouse1.35284203
75ZNF652_21678463_ChIP-ChIP_ZR75-1_Human1.34363406
76TP53_22127205_ChIP-Seq_IMR90_Human1.34316590
77MYC_22102868_ChIP-Seq_BL_Human1.33127171
78VDR_21846776_ChIP-Seq_THP-1_Human1.32332090
79ZFX_18555785_ChIP-Seq_MESCs_Mouse1.32180390
80NR0B1_18358816_ChIP-ChIP_MESCs_Mouse1.31768728
81LXR_22292898_ChIP-Seq_THP-1_Human1.30876301
82SOX2_18692474_ChIP-Seq_MEFs_Mouse1.29874571
83ERG_20887958_ChIP-Seq_HPC-7_Mouse1.29824930
84SPI1_22790984_ChIP-Seq_ERYTHROLEUKEMIA_Mouse1.29280074
85YY1_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse1.28687163
86TCF3_18692474_ChIP-Seq_MESCs_Mouse1.27557068
87PPARG_23326641_ChIP-Seq_C3H10T1-2_Mouse1.27405231
88ZFP281_18757296_ChIP-ChIP_E14_Mouse1.27166080
89NR1H3_23393188_ChIP-Seq_ATHEROSCLEROTIC-FOAM_Human1.23921991
90PPARG_19300518_ChIP-PET_3T3-L1_Mouse1.23680853
91ZFP42_18358816_ChIP-ChIP_MESCs_Mouse1.23054004
92KLF6_26769127_Chip-Seq_PDAC-Cell_line_Human1.23046806
93E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse1.21683011
94TBP_23326641_ChIP-Seq_C3H10T1-2_Mouse1.21534394
95TCFAP2C_20176728_ChIP-ChIP_TROPHOBLAST_STEM_CELLS_Mouse1.20584268
96CTCF_26484167_Chip-Seq_Bcells_Mouse1.20002008
97ELF1_20517297_ChIP-Seq_JURKAT_Human1.18380509
98CLOCK_20551151_ChIP-Seq_293T_Human1.16971924
99E2F4_21247883_ChIP-Seq_LYMPHOBLASTOID_Human1.16428099
100NANOG_18692474_ChIP-Seq_MEFs_Mouse1.16137617
101NKX2-5_21415370_ChIP-Seq_HL-1_Mouse1.15789517
102* STAT3_19079543_ChIP-ChIP_MESCs_Mouse1.15371517
103YY1_21170310_ChIP-Seq_MESCs_Mouse1.15202221
104SMAD4_19686287_ChIP-ChIP_HaCaT_Human1.15127264
105ASXL1_24218140_ChIP-Seq_BMDM_Mouse1.15078573
106TCF7_22412390_ChIP-Seq_EML_Mouse1.14100077
107CHD1_26751641_Chip-Seq_LNCaP_Human1.13878515
108* EZH2_18974828_ChIP-Seq_MESCs_Mouse1.12280932
109* RNF2_18974828_ChIP-Seq_MESCs_Mouse1.12280932
110SOX2_18358816_ChIP-ChIP_MESCs_Mouse1.12111517
111CTCF_21964334_Chip-Seq_Bcells_Human1.11971147
112FOXP3_21729870_ChIP-Seq_TREG_Human1.10876608
113KDM2B_26808549_Chip-Seq_SIL-ALL_Human1.10077712
114SA1_27219007_Chip-Seq_ERYTHROID_Human1.09823135
115SFPI1_20887958_ChIP-Seq_HPC-7_Mouse1.09531324
116FOXO3_22982991_ChIP-Seq_MACROPHAGES_Mouse1.09262011
117CTCF_27219007_Chip-Seq_ERYTHROID_Human1.08290179
118ESRRB_18555785_ChIP-Seq_MESCs_Mouse1.07594327
119GATA4_21415370_ChIP-Seq_HL-1_Mouse1.07573836
120UBF1/2_26484160_Chip-Seq_HMECs_Human1.07563193
121CREB1_26743006_Chip-Seq_LNCaP-abl_Human1.07410743
122CTCF_18555785_ChIP-Seq_MESCs_Mouse1.05674616
123NANOG_16153702_ChIP-ChIP_HESCs_Human1.05386138
124KLF4_18555785_ChIP-Seq_MESCs_Mouse1.04368143
125MYC_19079543_ChIP-ChIP_MESCs_Mouse1.03537603
126KDM2B_26808549_Chip-Seq_SUP-B15_Human1.03298402
127MYCN_18555785_ChIP-Seq_MESCs_Mouse1.03013638
128FOXP1_21924763_ChIP-Seq_HESCs_Human1.01713165
129NACC1_18358816_ChIP-ChIP_MESCs_Mouse1.01418910
130GABP_17652178_ChIP-ChIP_JURKAT_Human1.01290992
131TCF3_18467660_ChIP-ChIP_MESCs_Mouse1.00945362
132E2F4_17652178_ChIP-ChIP_JURKAT_Human1.00338235
133VDR_23849224_ChIP-Seq_CD4+_Human1.00240492
134P68_20966046_ChIP-Seq_HELA_Human0.98310679
135* TRIM28_19339689_ChIP-ChIP_MESCs_Mouse0.98265005
136GFI1B_20887958_ChIP-Seq_HPC-7_Mouse0.98182637
137CTCF_21964334_ChIP-Seq_BJAB-B_Human0.98140561
138* EP300_20729851_ChIP-Seq_FORBRAIN_MIDBRAIN_LIMB_HEART_Mouse0.98021281
139GATA2_22383799_ChIP-Seq_G1ME_Mouse0.97600874
140MAF_26560356_Chip-Seq_TH2_Human0.97600571
141CEBPB_21427703_ChIP-Seq_3T3-L1_Mouse0.97493059
142CCND1_20090754_ChIP-ChIP_RETINA_Mouse0.96388102
143* POU5F1_18358816_ChIP-ChIP_MESCs_Mouse0.96251301
144CREB1_23762244_ChIP-Seq_HIPPOCAMPUS_Rat0.96182663
145TCF4_18268006_ChIP-ChIP_LS174T_Human0.95202676
146POU5F1_16153702_ChIP-ChIP_HESCs_Human0.94949841
147ATF3_27146783_Chip-Seq_COLON_Human0.94555019
148ESR1_17901129_ChIP-ChIP_LIVER_Mouse0.94449020
149EST1_17652178_ChIP-ChIP_JURKAT_Human0.92983587
150TFEB_21752829_ChIP-Seq_HELA_Human0.92590760
151SALL4_18804426_ChIP-ChIP_MESCs_Mouse0.92222786
152ESR1_22446102_ChIP-Seq_UTERUS_Mouse0.91713890
153* TCF3_18347094_ChIP-ChIP_MESCs_Mouse0.91530121
154* BMI1_23680149_ChIP-Seq_NPCS_Mouse0.90831122
155MYC_19030024_ChIP-ChIP_MESCs_Mouse0.90779287
156HOXB4_20404135_ChIP-ChIP_EML_Mouse0.90720063
157ZFP281_27345836_Chip-Seq_ESCs_Mouse0.90421092
158ESR2_21235772_ChIP-Seq_MCF-7_Human0.90333383
159SOX2_27498859_Chip-Seq_STOMACH_Mouse0.88738792
160SETDB1_19884255_ChIP-Seq_MESCs_Mouse0.86596719
161P300_27058665_Chip-Seq_ZR-75-30cells_Human0.85981333
162TAL1_20887958_ChIP-Seq_HPC-7_Mouse0.85827037
163CSB_26484114_Chip-Seq_FIBROBLAST_Human0.84402981
164STAT5_23275557_ChIP-Seq_MAMMARY-EPITHELIUM_Mouse0.83851450
165ELK1_22589737_ChIP-Seq_MCF10A_Human0.83524588
166KLF4_26769127_Chip-Seq_PDAC-Cell_line_Human0.82795437
167SMAD1_18555785_ChIP-Seq_MESCs_Mouse0.82444284
168* SMAD2_18955504_ChIP-ChIP_HaCaT_Human0.81189690
169* SMAD3_18955504_ChIP-ChIP_HaCaT_Human0.81189690

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0000749_muscle_degeneration3.64816489
2MP0009250_abnormal_appendicular_skeleto3.38156731
3MP0008438_abnormal_cutaneous_collagen3.33557138
4MP0003283_abnormal_digestive_organ3.14439783
5MP0004858_abnormal_nervous_system2.90007632
6MP0004233_abnormal_muscle_weight2.82747630
7MP0005503_abnormal_tendon_morphology2.80388338
8MP0003942_abnormal_urinary_system2.75434521
9MP0000751_myopathy2.71695294
10MP0010030_abnormal_orbit_morphology2.66359100
11MP0010352_gastrointestinal_tract_polyps2.64669155
12MP0000372_irregular_coat_pigmentation2.59456610
13MP0009053_abnormal_anal_canal2.55456508
14MP0003646_muscle_fatigue2.53468982
15MP0000534_abnormal_ureter_morphology2.51351579
16MP0004036_abnormal_muscle_relaxation2.40996631
17MP0003878_abnormal_ear_physiology2.39927783
18MP0005377_hearing/vestibular/ear_phenot2.39927783
19MP0003806_abnormal_nucleotide_metabolis2.37987881
20MP0003941_abnormal_skin_development2.29033291
21MP0002396_abnormal_hematopoietic_system2.22308657
22MP0003123_paternal_imprinting2.07795262
23MP0006054_spinal_hemorrhage2.07013778
24MP0002932_abnormal_joint_morphology2.06479325
25MP0000013_abnormal_adipose_tissue2.04035236
26MP0004087_abnormal_muscle_fiber2.03308955
27MP0003705_abnormal_hypodermis_morpholog2.01328003
28MP0000003_abnormal_adipose_tissue1.99171901
29MP0002009_preneoplasia1.98692183
30MP0002249_abnormal_larynx_morphology1.96614228
31MP0006036_abnormal_mitochondrial_physio1.95597314
32MP0000681_abnormal_thyroid_gland1.94822324
33* MP0003385_abnormal_body_wall1.94234884
34MP0005330_cardiomyopathy1.88772839
35MP0003937_abnormal_limbs/digits/tail_de1.86380607
36MP0005451_abnormal_body_composition1.85064066
37MP0005670_abnormal_white_adipose1.79777242
38MP0000049_abnormal_middle_ear1.77870235
39MP0002254_reproductive_system_inflammat1.76130035
40MP0002269_muscular_atrophy1.76089241
41MP0004185_abnormal_adipocyte_glucose1.74816861
42MP0005369_muscle_phenotype1.74387665
43MP0000747_muscle_weakness1.73148535
44MP0005508_abnormal_skeleton_morphology1.70853145
45MP0005075_abnormal_melanosome_morpholog1.69772929
46MP0000767_abnormal_smooth_muscle1.69349642
47MP0003122_maternal_imprinting1.68857253
48MP0000538_abnormal_urinary_bladder1.66000280
49MP0002282_abnormal_trachea_morphology1.62971467
50MP0001958_emphysema1.61936401
51MP0010094_abnormal_chromosome_stability1.61380526
52MP0002106_abnormal_muscle_physiology1.61205241
53MP0002234_abnormal_pharynx_morphology1.59769029
54MP0003938_abnormal_ear_development1.54844958
55MP0004272_abnormal_basement_membrane1.54751483
56MP0005375_adipose_tissue_phenotype1.53202363
57MP0001661_extended_life_span1.52355426
58MP0004145_abnormal_muscle_electrophysio1.49460956
59MP0003279_aneurysm1.49450746
60* MP0002114_abnormal_axial_skeleton1.49323336
61MP0005023_abnormal_wound_healing1.48445431
62MP0004264_abnormal_extraembryonic_tissu1.47321594
63MP0008058_abnormal_DNA_repair1.46819789
64MP0005397_hematopoietic_system_phenotyp1.46067407
65MP0001545_abnormal_hematopoietic_system1.46067407
66* MP0002115_abnormal_skeleton_extremities1.45689426
67MP0000163_abnormal_cartilage_morphology1.45552524
68MP0005275_abnormal_skin_tensile1.42800911
69MP0010368_abnormal_lymphatic_system1.42059604
70* MP0002109_abnormal_limb_morphology1.41716348
71MP0002233_abnormal_nose_morphology1.41394891
72MP0004043_abnormal_pH_regulation1.39333743
73MP0003693_abnormal_embryo_hatching1.34983762
74MP0008007_abnormal_cellular_replicative1.34656122
75MP0009384_cardiac_valve_regurgitation1.34129688
76MP0001849_ear_inflammation1.33856976
77MP0000537_abnormal_urethra_morphology1.31582347
78MP0004957_abnormal_blastocyst_morpholog1.30220229
79MP0005623_abnormal_meninges_morphology1.29534399
80MP0005666_abnormal_adipose_tissue1.29315098
81MP0004134_abnormal_chest_morphology1.29310647
82* MP0003315_abnormal_perineum_morphology1.29236363
83MP0003111_abnormal_nucleus_morphology1.27226456
84MP0004084_abnormal_cardiac_muscle1.26529315
85MP0005187_abnormal_penis_morphology1.26040999
86MP0000678_abnormal_parathyroid_gland1.25770458
87MP0002089_abnormal_postnatal_growth/wei1.24440208
88MP0003828_pulmonary_edema1.24377484
89MP0000733_abnormal_muscle_development1.22932259
90MP0002971_abnormal_brown_adipose1.21734797
91MP0000465_gastrointestinal_hemorrhage1.20082708
92MP0009278_abnormal_bone_marrow1.19864138
93MP0009672_abnormal_birth_weight1.19771863
94MP0003077_abnormal_cell_cycle1.18927442
95MP0001346_abnormal_lacrimal_gland1.18608013
96MP0001727_abnormal_embryo_implantation1.17801794
97MP0010630_abnormal_cardiac_muscle1.17058894
98MP0002877_abnormal_melanocyte_morpholog1.14522378
99* MP0002113_abnormal_skeleton_development1.13040165
100MP0003115_abnormal_respiratory_system1.12826682
101MP0005620_abnormal_muscle_contractility1.12682044
102MP0000750_abnormal_muscle_regeneration1.11561285
103MP0003755_abnormal_palate_morphology1.09212126
104MP0004130_abnormal_muscle_cell1.09040164
105MP0003121_genomic_imprinting1.08527162
106MP0001664_abnormal_digestion1.07875226
107MP0009697_abnormal_copulation1.05614177
108MP0001879_abnormal_lymphatic_vessel1.05447258
109MP0004147_increased_porphyrin_level1.05416307
110MP0004808_abnormal_hematopoietic_stem1.03691534
111MP0003935_abnormal_craniofacial_develop1.02250893
112MP0000428_abnormal_craniofacial_morphol1.01418338
113MP0002135_abnormal_kidney_morphology1.00870245
114MP0003011_delayed_dark_adaptation0.99337370
115MP0001881_abnormal_mammary_gland0.98835740
116MP0000462_abnormal_digestive_system0.94979622
117MP0002111_abnormal_tail_morphology0.94457029
118MP0001270_distended_abdomen0.93948798
119MP0000477_abnormal_intestine_morphology0.93723783
120MP0008932_abnormal_embryonic_tissue0.93416969
121MP0000350_abnormal_cell_proliferation0.93347136
122MP0000516_abnormal_urinary_system0.92816850
123MP0005367_renal/urinary_system_phenotyp0.92816850
124MP0000432_abnormal_head_morphology0.92704377
125MP0008961_abnormal_basal_metabolism0.92367053
126MP0009379_abnormal_foot_pigmentation0.92052857
127MP0000762_abnormal_tongue_morphology0.91723028
128MP0004197_abnormal_fetal_growth/weight/0.91067152
129MP0002166_altered_tumor_susceptibility0.90183320
130MP0000490_abnormal_crypts_of0.89780591
131MP0002116_abnormal_craniofacial_bone0.89626518
132MP0005167_abnormal_blood-brain_barrier0.89151406
133MP0005266_abnormal_metabolism0.87464939
134MP0005380_embryogenesis_phenotype0.86548302
135MP0001672_abnormal_embryogenesis/_devel0.86548302
136MP0001177_atelectasis0.85276798
137MP0006138_congestive_heart_failure0.83538939
138MP0005390_skeleton_phenotype0.82559789
139MP0002132_abnormal_respiratory_system0.81464668
140MP0001614_abnormal_blood_vessel0.79936795
141MP0002085_abnormal_embryonic_tissue0.79926775
142MP0002088_abnormal_embryonic_growth/wei0.79755973
143MP0003786_premature_aging0.79282832
144MP0001348_abnormal_lacrimal_gland0.78228483
145MP0009643_abnormal_urine_homeostasis0.77856244
146MP0002108_abnormal_muscle_morphology0.77516313
147MP0003984_embryonic_growth_retardation0.77028796
148MP0001765_abnormal_ion_homeostasis0.76737573
149MP0002822_catalepsy0.76276601
150MP0002019_abnormal_tumor_incidence0.75359379
151MP0003566_abnormal_cell_adhesion0.75160677
152MP0003567_abnormal_fetal_cardiomyocyte0.74682039
153* MP0002160_abnormal_reproductive_system0.74474347
154MP0003950_abnormal_plasma_membrane0.72253318
155MP0002060_abnormal_skin_morphology0.72192232
156MP0002127_abnormal_cardiovascular_syste0.72122443
157MP0002128_abnormal_blood_circulation0.71696603
158MP0000759_abnormal_skeletal_muscle0.71368645
159MP0002332_abnormal_exercise_endurance0.70787879
160MP0003795_abnormal_bone_structure0.69430057
161MP0001764_abnormal_homeostasis0.66236721
162MP0001730_embryonic_growth_arrest0.62065168
163MP0003656_abnormal_erythrocyte_physiolo0.62012001
164MP0002970_abnormal_white_adipose0.61740578
165MP0000313_abnormal_cell_death0.60083377
166MP0001542_abnormal_bone_strength0.59475871

Predicted human phenotypes

RankGene SetZ-score
1Nemaline bodies (HP:0003798)6.98896813
2Muscle fiber inclusion bodies (HP:0100299)6.97438215
3Muscle fiber cytoplasmatic inclusion bodies (HP:0100303)6.82621531
4Exercise-induced myalgia (HP:0003738)6.02683050
5Type 1 muscle fiber predominance (HP:0003803)5.59053613
6Aplastic anemia (HP:0001915)5.19004004
7Septate vagina (HP:0001153)4.63604605
8Myopathic facies (HP:0002058)4.36233025
9Distal arthrogryposis (HP:0005684)4.17595145
10Centrally nucleated skeletal muscle fibers (HP:0003687)4.14298162
11Cupped ribs (HP:0000887)4.05871130
12Muscle hypertrophy of the lower extremities (HP:0008968)4.04061107
13Rhabdomyolysis (HP:0003201)3.98732348
14Radial bowing (HP:0002986)3.94541100
15Ureteral stenosis (HP:0000071)3.74387622
16Breech presentation (HP:0001623)3.72296492
17Muscle stiffness (HP:0003552)3.67432102
18Ulnar bowing (HP:0003031)3.66733196
19Myoglobinuria (HP:0002913)3.66355474
20Exercise-induced muscle cramps (HP:0003710)3.62128362
21Progressive muscle weakness (HP:0003323)3.58680091
22Abnormality of skeletal muscle fiber size (HP:0012084)3.55838267
23Abnormality of carpal bone ossification (HP:0006257)3.51971614
24EMG: myopathic abnormalities (HP:0003458)3.48059665
25Abnormality of the phalanges of the hallux (HP:0010057)3.39961731
26Ureteral obstruction (HP:0006000)3.39549566
27Neck muscle weakness (HP:0000467)3.39083190
28Abnormality of the 2nd finger (HP:0004100)3.36526177
29Protrusio acetabuli (HP:0003179)3.35286950
30Bifid tongue (HP:0010297)3.34778708
31Tongue fasciculations (HP:0001308)3.33681251
32Microglossia (HP:0000171)3.32763555
33Round ear (HP:0100830)3.31767084
34Metaphyseal cupping (HP:0003021)3.31764281
35Broad alveolar ridges (HP:0000187)3.25171520
36Facial hemangioma (HP:0000329)3.21900309
37Bicornuate uterus (HP:0000813)3.17686238
38Abnormal tarsal ossification (HP:0008369)3.17182622
39Increased variability in muscle fiber diameter (HP:0003557)3.13146110
40Muscle fibrillation (HP:0010546)3.12122386
41Absent phalangeal crease (HP:0006109)3.11962163
42Abnormal lung lobation (HP:0002101)3.10936612
43Abnormal ossification of hand bones (HP:0005921)3.09175525
44Ulnar deviation of the wrist (HP:0003049)3.08053324
45Premature rupture of membranes (HP:0001788)3.03018806
46Tracheal stenosis (HP:0002777)3.02110346
47Mesomelia (HP:0003027)3.01882914
48Hepatoblastoma (HP:0002884)2.99219533
49Bulbar palsy (HP:0001283)2.87294464
50Calf muscle hypertrophy (HP:0008981)2.84686013
51Aortic aneurysm (HP:0004942)2.82594587
52Ragged-red muscle fibers (HP:0003200)2.82342560
53Cervical subluxation (HP:0003308)2.78768701
54Bowed forearm bones (HP:0003956)2.78441700
55Bowing of the arm (HP:0006488)2.78441700
56Short 5th finger (HP:0009237)2.75550691
57Spinal rigidity (HP:0003306)2.75326460
58Abnormality of the distal phalanx of the thumb (HP:0009617)2.69514916
59Aortic dissection (HP:0002647)2.67694028
60Petechiae (HP:0000967)2.66744896
61Reduced antithrombin III activity (HP:0001976)2.64446212
62Abnormal hand bone ossification (HP:0010660)2.63949126
63Trismus (HP:0000211)2.63939215
64Spinal cord lesions (HP:0100561)2.63738200
65Syringomyelia (HP:0003396)2.63738200
66Hyporeflexia of lower limbs (HP:0002600)2.63440735
67Overlapping toe (HP:0001845)2.61840616
68Abnormal delivery (HP:0001787)2.61824837
69Abnormal foot bone ossification (HP:0010675)2.60456981
70Abnormality of the left ventricular outflow tract (HP:0011103)2.60220265
71Subaortic stenosis (HP:0001682)2.60220265
72Focal segmental glomerulosclerosis (HP:0000097)2.59784891
73Abnormality of the middle phalanges of the toes (HP:0010183)2.58151425
74Malignant hyperthermia (HP:0002047)2.57340425
75Ovoid vertebral bodies (HP:0003300)2.56669702
76Abnormality of the calf musculature (HP:0001430)2.54241497
77Abnormality of the alveolar ridges (HP:0006477)2.54106459
78Myotonia (HP:0002486)2.52981808
79Abnormal finger flexion creases (HP:0006143)2.49471390
80Deformed tarsal bones (HP:0008119)2.46294300
81Aplasia/Hypoplasia of the 5th finger (HP:0006262)2.45359112
82Increased connective tissue (HP:0009025)2.44282343
83Rimmed vacuoles (HP:0003805)2.43574322
84Calcaneovalgus deformity (HP:0001848)2.42293715
85Long clavicles (HP:0000890)2.39011962
86Reduced subcutaneous adipose tissue (HP:0003758)2.38392167
87Short middle phalanx of finger (HP:0005819)2.37298298
88Muscle fiber splitting (HP:0003555)2.36239425
89Aplasia/Hypoplasia involving the sinuses (HP:0009120)2.35654945
90Ankle contracture (HP:0006466)2.35039568
91Generalized amyotrophy (HP:0003700)2.34646042
92Aplasia/Hypoplasia of the frontal sinuses (HP:0009119)2.33770879
93Broad palm (HP:0001169)2.33371370
94Short middle phalanx of the 5th finger (HP:0004220)2.31715090
95Scapular winging (HP:0003691)2.30413021
96Short hallux (HP:0010109)2.29791694
97Increased muscle lipid content (HP:0009058)2.28381929
98Gastrointestinal dysmotility (HP:0002579)2.26717332
99Polycythemia (HP:0001901)2.24903872
100Abnormality of placental membranes (HP:0011409)2.22578797
101Amniotic constriction ring (HP:0009775)2.22578797
102Popliteal pterygium (HP:0009756)2.19658400
103Bilateral microphthalmos (HP:0007633)2.18850251
104Spondylolisthesis (HP:0003302)2.18657449
105Aplasia/Hypoplasia of the middle phalanx of the 5th finger (HP:0009161)2.17492938
106Abnormality of the 1st metacarpal (HP:0010009)2.16938452
107Abnormality of the calcaneus (HP:0008364)2.16757146
108Mildly elevated creatine phosphokinase (HP:0008180)2.16020371
109Hyperactive renin-angiotensin system (HP:0000841)2.12989762
110Coxa vara (HP:0002812)2.11323048
111Aplasia/Hypoplasia of the phalanges of the 5th finger (HP:0009376)2.11144242
112Areflexia of lower limbs (HP:0002522)2.10904935
113Absent frontal sinuses (HP:0002688)2.10866328
114Aplasia/Hypoplasia of the hallux (HP:0008362)2.10563426
115Glomerulosclerosis (HP:0000096)2.08422235
116Muscle fiber atrophy (HP:0100295)2.07734318
117Proximal placement of thumb (HP:0009623)2.05820295
118Abnormality of the 4th metacarpal (HP:0010012)2.04597503
119Increased intramyocellular lipid droplets (HP:0012240)2.04139832
120Self-mutilation (HP:0000742)2.04007348
121Aplasia/Hypoplasia of the 1st metacarpal (HP:0010026)2.03644014
122Short 1st metacarpal (HP:0010034)2.03644014
123Renal duplication (HP:0000075)2.03084984
124Metatarsus adductus (HP:0001840)2.01833330
125Weak cry (HP:0001612)2.01180436
126Bifid scrotum (HP:0000048)2.00567302
127Ulnar deviation of finger (HP:0009465)2.00565101
128Flared iliac wings (HP:0002869)2.00271411
129Broad metatarsal (HP:0001783)2.00070934
130Symphalangism affecting the phalanges of the hand (HP:0009773)1.99450288
131Deviation of the thumb (HP:0009603)1.98556871
132Nephroblastoma (Wilms tumor) (HP:0002667)1.98367047
133Acute lymphatic leukemia (HP:0006721)1.98215363
134Capillary hemangiomas (HP:0005306)1.96752640
135Abnormality of the umbilical cord (HP:0010881)1.95405449
136Advanced eruption of teeth (HP:0006288)1.94858035
137Type I transferrin isoform profile (HP:0003642)1.93883294
138Thoracolumbar scoliosis (HP:0002944)1.93418647
139Generalized muscle weakness (HP:0003324)1.93387384
140Embryonal renal neoplasm (HP:0011794)1.92306276
141Shallow orbits (HP:0000586)1.92122944
142Aplasia of the musculature (HP:0100854)1.91677758
143Abnormality of the acetabulum (HP:0003170)1.91304553
144Abnormality of the shoulder girdle musculature (HP:0001435)1.90083567
145Wrist flexion contracture (HP:0001239)1.88672142
146Asymmetric septal hypertrophy (HP:0001670)1.88089815
147Abnormality of the distal phalanges of the toes (HP:0010182)1.87592262
148Metabolic alkalosis (HP:0200114)1.87163152
149Type 2 muscle fiber atrophy (HP:0003554)1.86866910
150Fragile skin (HP:0001030)1.86609619
151Congenital diaphragmatic hernia (HP:0000776)1.83880012
152Dilated cardiomyopathy (HP:0001644)1.83071142
153Abnormal cartilage morphology (HP:0002763)1.82666937
154Abnormality of the proximal phalanges of the hand (HP:0009834)1.81887019
1552-3 toe syndactyly (HP:0004691)1.81868077
156Lipoatrophy (HP:0100578)1.81351212
157Abnormality of the phalanges of the 2nd finger (HP:0009541)1.81221653
158Abnormality of the middle phalanx of the 5th finger (HP:0004219)1.80687036
159Sensorimotor neuropathy (HP:0007141)1.80635854
160Broad toe (HP:0001837)1.79976747
161Soft skin (HP:0000977)1.79555973
162Fatigue (HP:0012378)1.79018253
163Distal lower limb amyotrophy (HP:0008944)1.78156953
164Gowers sign (HP:0003391)1.77635706
165Dysmetric saccades (HP:0000641)1.73475941
166Exercise intolerance (HP:0003546)1.72390874
167Sparse lateral eyebrow (HP:0005338)1.72233908
168Abnormal protein glycosylation (HP:0012346)1.71675714
169Abnormal glycosylation (HP:0012345)1.71675714
170Abnormal isoelectric focusing of serum transferrin (HP:0003160)1.71675714
171Abnormal protein N-linked glycosylation (HP:0012347)1.71675714
172Abnormality of the columella (HP:0009929)1.71442557
173Elbow flexion contracture (HP:0002987)1.71268957
174Respiratory insufficiency due to muscle weakness (HP:0002747)1.70093264
175Testicular atrophy (HP:0000029)1.69962981
176Distal lower limb muscle weakness (HP:0009053)1.69635430
177Abnormality of the fetal cardiovascular system (HP:0010948)1.68354031
178Abnormal umbilical cord blood vessels (HP:0011403)1.68354031
179Single umbilical artery (HP:0001195)1.68354031

Predicted kinase interactions (KEA)

RankGene SetZ-score
1TBK16.15293526
2OBSCN5.06530119
3TGFBR13.28422074
4IKBKE3.17089953
5TGFBR22.98408065
6ERN12.97218892
7GRK62.92899260
8PIM22.73287367
9PHKG22.68483256
10PHKG12.68483256
11VRK22.45739690
12MAP2K32.43185394
13DDR22.38058406
14MYLK2.35379163
15TTN2.34692453
16ARAF2.02778292
17CDK122.01864041
18MATK1.93333252
19CDK81.85116268
20PBK1.74004385
21TAOK11.68256302
22MST1R1.61696147
23PAK41.60583893
24IRAK31.51034988
25ABL21.46721478
26EPHB21.45825639
27CCNB11.44559784
28CDC71.43177179
29MKNK11.42343342
30PDPK11.42010540
31PRKG21.34720705
32EEF2K1.34716446
33GRK51.33428401
34PDGFRA1.33342080
35IKBKB1.31734641
36PIK3CG1.31600810
37TRIB31.28933762
38CSF1R1.27992141
39MUSK1.23538725
40STK101.22826092
41AKT31.21020381
42DMPK1.20505575
43PINK11.16812636
44TAOK21.12391664
45KIT1.11734027
46SMG11.11128233
47NME21.10220024
48MST41.08728661
49CDK71.08071016
50PDK11.03912673
51BUB11.03305547
52BRSK21.03005897
53LATS21.02215598
54MAP3K31.00714304
55RPS6KB20.99035567
56PKN20.98921450
57MAPK110.98001175
58LRRK20.93324206
59FLT30.93306382
60MAP3K80.91920601
61WNK40.91007292
62MAP3K130.90641302
63EPHA20.90333895
64MAPKAPK30.90320970
65WNK10.89918140
66CHEK20.87412018
67NME10.87167964
68PAK20.85785618
69MAP4K20.85296295
70PDK20.83413393
71BRAF0.82841550
72WEE10.81829207
73ADRBK10.80828131
74PASK0.80456205
75LIMK10.80250234
76NTRK10.78593168
77TTK0.78072907
78RPS6KA20.77123345
79MAP3K10.76727432
80MAPK70.76549660
81MOS0.73582698
82STK160.72865537
83TESK10.72298434
84MAP3K100.71630893
85MAP2K20.71331551
86ADRBK20.70777840
87MTOR0.69052383
88ZAK0.68822304
89CDK90.67735681
90AURKB0.67669308
91PIM10.67632957
92TIE10.67178197
93PIK3CA0.67176084
94VRK10.67163981
95MAP3K70.65303128
96ATR0.65259493
97PLK10.64482069
98BMPR1B0.63795411
99WNK30.63764951
100PTK20.63418528
101MAPK120.62945094
102NEK90.61099210
103ERBB30.60356683
104TRPM70.59975308
105CHEK10.59672201
106RPS6KL10.59292656
107RPS6KC10.59292656
108OXSR10.57208176
109SCYL20.56799484
110RPS6KA60.56458012
111PAK10.55266758
112AURKA0.55219259
113CDK40.54110063
114MELK0.52527597
115PRKCI0.52431869
116EIF2AK30.49429769
117KDR0.47574234
118CAMK1G0.45682640
119TESK20.45388960
120NEK20.45341270
121CAMK2G0.44747487
122FRK0.43787794
123MAP2K60.43757726
124RPS6KA40.42413678
125PRKAA20.42323977
126RPS6KB10.41542211
127PRPF4B0.40342614
128CDK60.40209727
129NEK10.40187450
130CDK20.40123588
131ICK0.39814092
132NUAK10.39604905
133RAF10.38838154
134MAP3K110.38677168
135GRK10.37675330
136EIF2AK10.36902402
137MAPK40.36043551
138BCKDK0.35019077
139CSNK2A20.34792838
140ILK0.34314070
141PRKD20.33653565
142MAPKAPK50.33618696
143MKNK20.33420108
144LATS10.33242396
145PRKD10.31952067
146TLK10.31951036
147PTK60.31499738
148MARK20.31129868
149MAP2K10.30803568
150AKT20.30632125
151MAPK30.29203678
152FGFR10.26946917

Predicted pathways (KEGG)

RankGene SetZ-score
1Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006034.34569975
22-Oxocarboxylic acid metabolism_Homo sapiens_hsa012102.76881511
3Galactose metabolism_Homo sapiens_hsa000522.43237027
4Sulfur metabolism_Homo sapiens_hsa009202.41999312
5Pyrimidine metabolism_Homo sapiens_hsa002402.36413890
6Fructose and mannose metabolism_Homo sapiens_hsa000512.36063600
7Butirosin and neomycin biosynthesis_Homo sapiens_hsa005242.36006864
8Citrate cycle (TCA cycle)_Homo sapiens_hsa000202.22827701
9Nucleotide excision repair_Homo sapiens_hsa034202.17051734
10Ribosome_Homo sapiens_hsa030102.16378982
11Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007602.08957192
12Pentose and glucuronate interconversions_Homo sapiens_hsa000402.07414571
13Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa005341.99958971
14One carbon pool by folate_Homo sapiens_hsa006701.98088239
15Homologous recombination_Homo sapiens_hsa034401.96434163
16Steroid biosynthesis_Homo sapiens_hsa001001.93932049
17RIG-I-like receptor signaling pathway_Homo sapiens_hsa046221.84142324
18Mineral absorption_Homo sapiens_hsa049781.82971545
19Thyroid cancer_Homo sapiens_hsa052161.81751537
20Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate_Homo sapiens_hsa005321.81680751
21ECM-receptor interaction_Homo sapiens_hsa045121.79990981
22Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006011.77530820
23Biosynthesis of amino acids_Homo sapiens_hsa012301.71945065
24Cyanoamino acid metabolism_Homo sapiens_hsa004601.70690664
25Ascorbate and aldarate metabolism_Homo sapiens_hsa000531.69098412
26RNA polymerase_Homo sapiens_hsa030201.63201993
27Non-homologous end-joining_Homo sapiens_hsa034501.61102944
28Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa009701.60905128
29Purine metabolism_Homo sapiens_hsa002301.60128257
30Pancreatic cancer_Homo sapiens_hsa052121.52145354
31* Transcriptional misregulation in cancer_Homo sapiens_hsa052021.50057664
32Hedgehog signaling pathway_Homo sapiens_hsa043401.49588627
33Arachidonic acid metabolism_Homo sapiens_hsa005901.45457029
34Focal adhesion_Homo sapiens_hsa045101.44069380
35Protein digestion and absorption_Homo sapiens_hsa049741.40760174
36Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001301.37624093
37Pertussis_Homo sapiens_hsa051331.37485036
38Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa005201.33999087
39Glycosaminoglycan degradation_Homo sapiens_hsa005311.33023797
40Fanconi anemia pathway_Homo sapiens_hsa034601.31755620
41DNA replication_Homo sapiens_hsa030301.31434634
42Basal cell carcinoma_Homo sapiens_hsa052171.25458231
43Bladder cancer_Homo sapiens_hsa052191.25379708
44PI3K-Akt signaling pathway_Homo sapiens_hsa041511.24846378
45Arginine and proline metabolism_Homo sapiens_hsa003301.24476417
46Cytosolic DNA-sensing pathway_Homo sapiens_hsa046231.23973575
47Proteoglycans in cancer_Homo sapiens_hsa052051.23940195
48Base excision repair_Homo sapiens_hsa034101.23526498
49Dilated cardiomyopathy_Homo sapiens_hsa054141.20970478
50Glucagon signaling pathway_Homo sapiens_hsa049221.17635416
51Other glycan degradation_Homo sapiens_hsa005111.14899538
52Hepatitis C_Homo sapiens_hsa051601.14623245
53Starch and sucrose metabolism_Homo sapiens_hsa005001.14467292
54Sulfur relay system_Homo sapiens_hsa041221.13800300
55Cell cycle_Homo sapiens_hsa041101.12402982
56Rap1 signaling pathway_Homo sapiens_hsa040151.11436500
57Glycolysis / Gluconeogenesis_Homo sapiens_hsa000101.10013437
58Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005331.09421758
59Longevity regulating pathway - multiple species_Homo sapiens_hsa042131.07792011
60TGF-beta signaling pathway_Homo sapiens_hsa043501.05303928
61Central carbon metabolism in cancer_Homo sapiens_hsa052301.05059390
62Longevity regulating pathway - mammal_Homo sapiens_hsa042111.04021105
63Pentose phosphate pathway_Homo sapiens_hsa000301.03640769
64Parkinsons disease_Homo sapiens_hsa050120.93297721
65Hippo signaling pathway_Homo sapiens_hsa043900.93070480
66Pathways in cancer_Homo sapiens_hsa052000.92611587
67Melanoma_Homo sapiens_hsa052180.90609935
68Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005120.90538172
69Valine, leucine and isoleucine degradation_Homo sapiens_hsa002800.90308876
70Glutathione metabolism_Homo sapiens_hsa004800.89516300
71Leukocyte transendothelial migration_Homo sapiens_hsa046700.89425798
72Adipocytokine signaling pathway_Homo sapiens_hsa049200.89120187
73AMPK signaling pathway_Homo sapiens_hsa041520.88155476
74Phenylalanine metabolism_Homo sapiens_hsa003600.87832140
75Salmonella infection_Homo sapiens_hsa051320.87328438
76Cardiac muscle contraction_Homo sapiens_hsa042600.86994635
77Fatty acid elongation_Homo sapiens_hsa000620.86852405
78Fatty acid degradation_Homo sapiens_hsa000710.84903551
79MicroRNAs in cancer_Homo sapiens_hsa052060.83319032
80Chronic myeloid leukemia_Homo sapiens_hsa052200.81888068
81Arrhythmogenic right ventricular cardiomyopathy (ARVC)_Homo sapiens_hsa054120.81254084
82Insulin signaling pathway_Homo sapiens_hsa049100.79163145
83Small cell lung cancer_Homo sapiens_hsa052220.79030201
84Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049320.78796416
85Bacterial invasion of epithelial cells_Homo sapiens_hsa051000.78727454
86Cysteine and methionine metabolism_Homo sapiens_hsa002700.78211189
87Choline metabolism in cancer_Homo sapiens_hsa052310.77035664
88Carbon metabolism_Homo sapiens_hsa012000.76798868
89Arginine biosynthesis_Homo sapiens_hsa002200.75981952
90Viral carcinogenesis_Homo sapiens_hsa052030.75715188
91Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa045500.75670505
92Propanoate metabolism_Homo sapiens_hsa006400.75065951
93Fatty acid metabolism_Homo sapiens_hsa012120.74035646
94Influenza A_Homo sapiens_hsa051640.73851073
95Regulation of lipolysis in adipocytes_Homo sapiens_hsa049230.73629264
96Folate biosynthesis_Homo sapiens_hsa007900.72475456
97Insulin resistance_Homo sapiens_hsa049310.71589444
98Circadian rhythm_Homo sapiens_hsa047100.71311565
99Adherens junction_Homo sapiens_hsa045200.70970369
100Selenocompound metabolism_Homo sapiens_hsa004500.70894967
101Herpes simplex infection_Homo sapiens_hsa051680.70598633
102RNA degradation_Homo sapiens_hsa030180.69399718
103Lysine degradation_Homo sapiens_hsa003100.69327133
104Phospholipase D signaling pathway_Homo sapiens_hsa040720.68689011
105Hepatitis B_Homo sapiens_hsa051610.67190575
106Proteasome_Homo sapiens_hsa030500.66775856
107AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa049330.66331191
108Malaria_Homo sapiens_hsa051440.64688306
109Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005630.64596176
110p53 signaling pathway_Homo sapiens_hsa041150.63928986
111cGMP-PKG signaling pathway_Homo sapiens_hsa040220.63851156
112Toll-like receptor signaling pathway_Homo sapiens_hsa046200.63479569
113Shigellosis_Homo sapiens_hsa051310.63134988
114Regulation of actin cytoskeleton_Homo sapiens_hsa048100.61602146
115Peroxisome_Homo sapiens_hsa041460.61227968
116Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004000.60559163
117Alzheimers disease_Homo sapiens_hsa050100.59878710
118HIF-1 signaling pathway_Homo sapiens_hsa040660.59154067
119VEGF signaling pathway_Homo sapiens_hsa043700.59032375
120RNA transport_Homo sapiens_hsa030130.57756945
121Drug metabolism - other enzymes_Homo sapiens_hsa009830.56759014
122Ubiquitin mediated proteolysis_Homo sapiens_hsa041200.56547299
123Tight junction_Homo sapiens_hsa045300.55641115
124Huntingtons disease_Homo sapiens_hsa050160.55614356
125Prostate cancer_Homo sapiens_hsa052150.55391347
126mRNA surveillance pathway_Homo sapiens_hsa030150.54923623
127Platelet activation_Homo sapiens_hsa046110.54910903
128Measles_Homo sapiens_hsa051620.53375695
129N-Glycan biosynthesis_Homo sapiens_hsa005100.52438827
130Calcium signaling pathway_Homo sapiens_hsa040200.51942430
131Metabolic pathways_Homo sapiens_hsa011000.51825339
132Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006300.51686816
133Hypertrophic cardiomyopathy (HCM)_Homo sapiens_hsa054100.50363958
134Spliceosome_Homo sapiens_hsa030400.49735512
135Acute myeloid leukemia_Homo sapiens_hsa052210.48889978
136Non-small cell lung cancer_Homo sapiens_hsa052230.48499870
137Apoptosis_Homo sapiens_hsa042100.47432378
138mTOR signaling pathway_Homo sapiens_hsa041500.47332344
139HTLV-I infection_Homo sapiens_hsa051660.47074395
140Renin-angiotensin system_Homo sapiens_hsa046140.46907357
141Protein processing in endoplasmic reticulum_Homo sapiens_hsa041410.46410586
142Pyruvate metabolism_Homo sapiens_hsa006200.44893769
143Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030080.44695267
144Basal transcription factors_Homo sapiens_hsa030220.44229455
145Fatty acid biosynthesis_Homo sapiens_hsa000610.43293912
146Leishmaniasis_Homo sapiens_hsa051400.43185255
147Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002500.42738648
148Systemic lupus erythematosus_Homo sapiens_hsa053220.42238614
149Mismatch repair_Homo sapiens_hsa034300.41208030
150Pathogenic Escherichia coli infection_Homo sapiens_hsa051300.41060644
151Oxidative phosphorylation_Homo sapiens_hsa001900.39664785
152Tryptophan metabolism_Homo sapiens_hsa003800.39364822
153Tyrosine metabolism_Homo sapiens_hsa003500.39362836
154Cytokine-cytokine receptor interaction_Homo sapiens_hsa040600.38100256
155Chemical carcinogenesis_Homo sapiens_hsa052040.36311236
156Oxytocin signaling pathway_Homo sapiens_hsa049210.36172271
157Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006040.35985456
158Ras signaling pathway_Homo sapiens_hsa040140.35486290
159Amyotrophic lateral sclerosis (ALS)_Homo sapiens_hsa050140.34602484

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