HOXA11

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: In vertebrates, the genes encoding the class of transcription factors called homeobox genes are found in clusters named A, B, C, and D on four separate chromosomes. Expression of these proteins is spatially and temporally regulated during embryonic development. This gene is part of the A cluster on chromosome 7 and encodes a DNA-binding transcription factor which may regulate gene expression, morphogenesis, and differentiation. This gene is involved in the regulation of uterine development and is required for female fertility. Mutations in this gene can cause radio-ulnar synostosis with amegakaryocytic thrombocytopenia. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1lymph vessel development (GO:0001945)5.51268102
2* proximal/distal pattern formation (GO:0009954)5.38930758
3mesenchymal to epithelial transition involved in metanephros morphogenesis (GO:0003337)5.20067898
4chondrocyte proliferation (GO:0035988)4.76995964
5negative regulation of epidermis development (GO:0045683)4.51877389
6* embryonic skeletal joint morphogenesis (GO:0060272)4.48253577
7regulation of branching involved in prostate gland morphogenesis (GO:0060687)4.43297011
8metanephric mesenchyme development (GO:0072075)4.28669040
9cell migration involved in heart development (GO:0060973)4.26328122
10bone trabecula formation (GO:0060346)4.23333924
11notochord development (GO:0030903)4.19726221
12branching involved in prostate gland morphogenesis (GO:0060442)4.17609824
13collagen fibril organization (GO:0030199)4.17469512
14maturation of SSU-rRNA (GO:0030490)4.08884488
15prostate epithelial cord arborization involved in prostate glandular acinus morphogenesis (GO:0060523.99974399
16kidney mesenchyme development (GO:0072074)3.99934605
17middle ear morphogenesis (GO:0042474)3.96246589
18peripheral nervous system neuron development (GO:0048935)3.92495960
19vitamin A metabolic process (GO:0006776)3.92311840
20heterochromatin organization (GO:0070828)3.88903689
21branching involved in mammary gland duct morphogenesis (GO:0060444)3.85948177
22positive regulation of macrophage activation (GO:0043032)3.83854174
23tooth mineralization (GO:0034505)3.78045180
24positive regulation of respiratory burst (GO:0060267)3.73721545
25mesenchymal-epithelial cell signaling (GO:0060638)3.73437568
26* forelimb morphogenesis (GO:0035136)3.67470822
27daunorubicin metabolic process (GO:0044597)3.65416948
28polyketide metabolic process (GO:0030638)3.65416948
29doxorubicin metabolic process (GO:0044598)3.65416948
30protein retention in ER lumen (GO:0006621)3.64902147
31regulation of hair follicle development (GO:0051797)3.64660968
32* embryonic forelimb morphogenesis (GO:0035115)3.64448221
33regulation of apoptotic process involved in morphogenesis (GO:1902337)3.63719210
34hormone catabolic process (GO:0042447)3.62457032
35* organ induction (GO:0001759)3.62427347
36ribosomal small subunit biogenesis (GO:0042274)3.57573751
37muscle cell fate commitment (GO:0042693)3.54826982
38negative regulation of complement activation (GO:0045916)3.54329527
39cell proliferation involved in metanephros development (GO:0072203)3.50488316
40paraxial mesoderm development (GO:0048339)3.49123520
41planar cell polarity pathway involved in neural tube closure (GO:0090179)3.47532465
42mesenchymal to epithelial transition (GO:0060231)3.46015120
43outer ear morphogenesis (GO:0042473)3.45732926
44regulation of mammary gland epithelial cell proliferation (GO:0033599)3.44959434
45basement membrane organization (GO:0071711)3.42564857
46sequestering of extracellular ligand from receptor (GO:0035581)3.42153504
47protein localization to kinetochore (GO:0034501)3.39984454
48negative regulation of intracellular estrogen receptor signaling pathway (GO:0033147)3.39472662
49regulation of translational termination (GO:0006449)3.36342168
50polarized epithelial cell differentiation (GO:0030859)3.34466194
51maintenance of protein localization in endoplasmic reticulum (GO:0035437)3.34438374
52* embryonic skeletal system morphogenesis (GO:0048704)3.33569437
53skin morphogenesis (GO:0043589)3.33192268
54male genitalia development (GO:0030539)3.33109325
55regulation of odontogenesis of dentin-containing tooth (GO:0042487)3.32080053
56maternal placenta development (GO:0001893)3.30800721
57endocardial cushion development (GO:0003197)3.29113046
58negative regulation of homotypic cell-cell adhesion (GO:0034111)3.28577252
59outflow tract septum morphogenesis (GO:0003148)3.28447414
60negative regulation of G2/M transition of mitotic cell cycle (GO:0010972)3.27275574
61diterpenoid biosynthetic process (GO:0016102)3.26864400
62regulation of establishment of planar polarity involved in neural tube closure (GO:0090178)3.26864012
63mesenchymal cell proliferation (GO:0010463)3.26650537
64adherens junction assembly (GO:0034333)3.26170679
65hypotonic response (GO:0006971)3.24305957
66epithelial cell differentiation involved in prostate gland development (GO:0060742)3.13577660
67regulation of heart morphogenesis (GO:2000826)3.13337599
68cranial nerve morphogenesis (GO:0021602)3.13098655
69proline biosynthetic process (GO:0006561)3.12692208
70cochlea morphogenesis (GO:0090103)3.09912888
71sphingosine metabolic process (GO:0006670)3.07812737
72apoptotic cell clearance (GO:0043277)3.07621552
73thyroid gland development (GO:0030878)3.03806103
74muscle organ morphogenesis (GO:0048644)3.02050446
75negative regulation of fibroblast growth factor receptor signaling pathway (GO:0040037)3.01894449
76endodermal cell differentiation (GO:0035987)3.01689082
77regulation of apoptotic cell clearance (GO:2000425)3.01310059
78* cartilage development involved in endochondral bone morphogenesis (GO:0060351)3.00467888
79midgut development (GO:0007494)3.00189186
80positive regulation of odontogenesis (GO:0042482)2.98582781
81hindlimb morphogenesis (GO:0035137)2.98050305
82mRNA stabilization (GO:0048255)2.95584913
83RNA stabilization (GO:0043489)2.95584913
84cell-substrate adherens junction assembly (GO:0007045)2.94923956
85focal adhesion assembly (GO:0048041)2.94923956
86embryonic cranial skeleton morphogenesis (GO:0048701)2.94010081
87extracellular matrix assembly (GO:0085029)2.92453394
88protein heterotrimerization (GO:0070208)2.91130054
89eyelid development in camera-type eye (GO:0061029)2.89944310
90negative regulation of fatty acid transport (GO:2000192)2.89486497
91artery morphogenesis (GO:0048844)2.89280245
92hippo signaling (GO:0035329)2.88623095
93negative regulation of cell cycle G2/M phase transition (GO:1902750)2.88141911
94anterior/posterior axis specification, embryo (GO:0008595)2.87924115
95positive regulation of smoothened signaling pathway (GO:0045880)2.87753252
96* uterus development (GO:0060065)2.87172057
97embryonic heart tube development (GO:0035050)2.84391758
98neuron projection extension involved in neuron projection guidance (GO:1902284)2.80886704
99axon extension involved in axon guidance (GO:0048846)2.80886704
100bone morphogenesis (GO:0060349)2.80609699
101rRNA transcription (GO:0009303)2.80407930
102vascular endothelial growth factor receptor signaling pathway (GO:0048010)2.79900902
103reproductive system development (GO:0061458)2.77668875
104mammary gland epithelial cell differentiation (GO:0060644)2.77096852
105regulation of glucose import in response to insulin stimulus (GO:2001273)2.77055876
106chromatin assembly (GO:0031497)2.76316735
107craniofacial suture morphogenesis (GO:0097094)2.76147028
108nucleobase-containing small molecule interconversion (GO:0015949)2.76121715
109* embryonic appendage morphogenesis (GO:0035113)2.75281075
110* embryonic limb morphogenesis (GO:0030326)2.75281075
111cardiac muscle cell proliferation (GO:0060038)2.75178332
112heart trabecula formation (GO:0060347)2.74791850
113* skeletal system morphogenesis (GO:0048705)2.73934802
114negative regulation of stem cell proliferation (GO:2000647)2.73656073
115regulation of cardioblast differentiation (GO:0051890)2.73565673
116negative regulation of catenin import into nucleus (GO:0035414)2.73442728
117negative regulation of epidermal cell differentiation (GO:0045605)2.73369692
118trabecula formation (GO:0060343)2.72341821
119regulation of secondary heart field cardioblast proliferation (GO:0003266)2.72203353
120regulation of cardioblast proliferation (GO:0003264)2.72203353
121negative regulation of protein activation cascade (GO:2000258)2.71804347
122negative regulation of humoral immune response (GO:0002921)2.71586735
123morphogenesis of an epithelial fold (GO:0060571)2.71206610
124keratan sulfate catabolic process (GO:0042340)2.70298525
125body morphogenesis (GO:0010171)2.70210013
126endothelial cell morphogenesis (GO:0001886)2.69738106
127head development (GO:0060322)2.69732743
128positive regulation of transforming growth factor beta receptor signaling pathway (GO:0030511)2.69620609
129primitive streak formation (GO:0090009)2.69520472
130* limb morphogenesis (GO:0035108)2.68997836
131* appendage morphogenesis (GO:0035107)2.68997836
132* regulation of organ formation (GO:0003156)2.68288232
133Wnt signaling pathway, planar cell polarity pathway (GO:0060071)2.67926226
134* embryonic organ morphogenesis (GO:0048562)2.67422979
135collagen metabolic process (GO:0032963)2.67402362
136cellular protein complex localization (GO:0034629)2.66546664
137vascular endothelial growth factor signaling pathway (GO:0038084)2.65321863
138lipopolysaccharide biosynthetic process (GO:0009103)2.64911744
139COPI coating of Golgi vesicle (GO:0048205)2.62933892
140Golgi transport vesicle coating (GO:0048200)2.62933892
141neural crest cell development (GO:0014032)2.62453521
142regulation of single stranded viral RNA replication via double stranded DNA intermediate (GO:00450912.62288774
143negative regulation of mRNA splicing, via spliceosome (GO:0048025)2.61225823
144anterior/posterior axis specification (GO:0009948)2.61086291
145positive regulation of tumor necrosis factor biosynthetic process (GO:0042535)2.60965528
146maintenance of protein location in nucleus (GO:0051457)2.60829770
147muscle cell migration (GO:0014812)2.60768678
148diol metabolic process (GO:0034311)2.60399949
149regulation of translational fidelity (GO:0006450)2.59851847
150G-protein coupled receptor signaling pathway coupled to cGMP nucleotide second messenger (GO:00071992.59290125
151regulation of establishment of planar polarity (GO:0090175)2.58806569
152regulation of intracellular estrogen receptor signaling pathway (GO:0033146)2.58542181
153folic acid metabolic process (GO:0046655)2.57579950
154replicative senescence (GO:0090399)2.57218378
155regulation of vascular endothelial growth factor signaling pathway (GO:1900746)2.55295539
156protein complex localization (GO:0031503)2.52991653
157cardiac septum morphogenesis (GO:0060411)2.49799354
158diaphragm development (GO:0060539)2.49531708
159cell-substrate junction assembly (GO:0007044)2.47821224
160positive regulation of DNA-dependent DNA replication (GO:2000105)2.46960672
161mitotic chromosome condensation (GO:0007076)2.45173984
162regulation of glucocorticoid metabolic process (GO:0031943)2.44843099
163embryonic process involved in female pregnancy (GO:0060136)2.44358284
164DNA unwinding involved in DNA replication (GO:0006268)2.42308155

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1KLF2_18264089_ChIP-ChIP_MESCs_Mouse4.53667438
2KLF5_18264089_ChIP-ChIP_MESCs_Mouse4.53667438
3KLF4_18264089_ChIP-ChIP_MESCs_Mouse4.53667438
4RARG_19884340_ChIP-ChIP_MEFs_Mouse3.08235544
5TP63_19390658_ChIP-ChIP_HaCaT_Human3.01839398
6TRIM28_21343339_ChIP-Seq_HEK293_Human2.82827104
7HIF1A_21447827_ChIP-Seq_MCF-7_Human2.57637015
8ZFP281_18358816_ChIP-ChIP_MESCs_Mouse2.51618851
9TP63_17297297_ChIP-ChIP_HaCaT_Human2.48081786
10WT1_20215353_ChIP-ChIP_NEPHRON_PROGENITOR_Mouse2.44615904
11TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat2.44310065
12BP1_19119308_ChIP-ChIP_Hs578T_Human2.40612073
13HCFC1_20581084_ChIP-Seq_MESCs_Mouse2.35111583
14TBP_23326641_ChIP-Seq_C3H10T1-2_Mouse2.35003088
15VDR_21846776_ChIP-Seq_THP-1_Human2.32985076
16XRN2_22483619_ChIP-Seq_HELA_Human2.30120120
17* EED_16625203_ChIP-ChIP_MESCs_Mouse2.28445355
18E2F7_22180533_ChIP-Seq_HELA_Human2.28128546
19TCF3_18692474_ChIP-Seq_MEFs_Mouse2.26082147
20NUCKS1_24931609_ChIP-Seq_HEPATOCYTES_Mouse2.25417951
21EGR1_19374776_ChIP-ChIP_THP-1_Human2.24523646
22NANOG_18700969_ChIP-ChIP_MESCs_Mouse2.24424999
23FOXM1_23109430_ChIP-Seq_U2OS_Human2.18506376
24RUNX2_24764292_ChIP-Seq_MC3T3_Mouse2.12394040
25CLOCK_20551151_ChIP-Seq_293T_Human2.11763448
26SOX2_18358816_ChIP-ChIP_MESCs_Mouse2.08073516
27ZFP281_18757296_ChIP-ChIP_E14_Mouse2.05681586
28POU5F1_18700969_ChIP-ChIP_MESCs_Mouse2.01537678
29* ELK3_25401928_ChIP-Seq_HUVEC_Human2.01493850
30ZNF263_19887448_ChIP-Seq_K562_Human2.01080537
31ESR1_15608294_ChIP-ChIP_MCF-7_Human1.97070428
32WT1_19549856_ChIP-ChIP_CCG9911_Human1.91850521
33* CHD7_19251738_ChIP-ChIP_MESCs_Mouse1.89597052
34DACH1_20351289_ChIP-Seq_MDA-MB-231_Human1.88135872
35* TP53_20018659_ChIP-ChIP_R1E_Mouse1.84713569
36MYC_18358816_ChIP-ChIP_MESCs_Mouse1.84370245
37KLF4_18358816_ChIP-ChIP_MESCs_Mouse1.80658123
38SMAD3_22036565_ChIP-Seq_ESCs_Mouse1.79913213
39TCF21_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human1.78307669
40EP300_20729851_ChIP-Seq_FORBRAIN_MIDBRAIN_LIMB_HEART_Mouse1.77346928
41TCF3_18692474_ChIP-Seq_MESCs_Mouse1.75574186
42* CNOT3_19339689_ChIP-ChIP_MESCs_Mouse1.74039712
43TRP63_18441228_ChIP-ChIP_KERATINOCYTES_Mouse1.73699645
44ZFP281_27345836_Chip-Seq_ESCs_Mouse1.73225909
45PPARD_23176727_ChIP-Seq_KERATINOCYTES_Mouse1.72604740
46THAP11_20581084_ChIP-Seq_MESCs_Mouse1.70854046
47CCND1_20090754_ChIP-ChIP_RETINA_Mouse1.68856822
48ZIC3_20872845_ChIP-ChIP_MESCs_Mouse1.68544218
49CDX2_20551321_ChIP-Seq_CACO-2_Human1.64889436
50MYC_19030024_ChIP-ChIP_MESCs_Mouse1.64302380
51ESR2_21235772_ChIP-Seq_MCF-7_Human1.63215439
52RACK7_27058665_Chip-Seq_MCF-7_Human1.63186788
53* EZH2_27304074_Chip-Seq_ESCs_Mouse1.61772590
54ESR1_21235772_ChIP-Seq_MCF-7_Human1.59937292
55ZFX_18555785_ChIP-Seq_MESCs_Mouse1.58536370
56TCF3_18467660_ChIP-ChIP_MESCs_Mouse1.58266013
57PPARG_19300518_ChIP-PET_3T3-L1_Mouse1.57062512
58TAF7L_23326641_ChIP-Seq_C3H10T1-2_Mouse1.56820989
59TP53_22127205_ChIP-Seq_IMR90_Human1.55084980
60* NANOG_18347094_ChIP-ChIP_MESCs_Mouse1.54894197
61ESR1_22446102_ChIP-Seq_UTERUS_Mouse1.53768365
62TTF2_22483619_ChIP-Seq_HELA_Human1.53086814
63DCP1A_22483619_ChIP-Seq_HELA_Human1.53083260
64* STAT3_19079543_ChIP-ChIP_MESCs_Mouse1.52124579
65STAT6_21828071_ChIP-Seq_BEAS2B_Human1.50478570
66JARID1A_20064375_ChIP-Seq_MESCs_Mouse1.49304927
67* TET1_21451524_ChIP-Seq_MESCs_Mouse1.48657378
68FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse1.45821711
69AR_21909140_ChIP-Seq_LNCAP_Human1.44735036
70HOXD13_18407260_ChIP-ChIP_DEVELOPING-LIMBS_Mouse1.43303846
71STAT3_1855785_ChIP-Seq_MESCs_Mouse1.42347120
72* JARID2_20075857_ChIP-Seq_MESCs_Mouse1.41359681
73UBF1/2_26484160_Chip-Seq_HMEC-DERIVED_Human1.40769215
74NACC1_18358816_ChIP-ChIP_MESCs_Mouse1.40026925
75KLF6_26769127_Chip-Seq_PDAC-Cell_line_Human1.39715774
76* TCF3_18347094_ChIP-ChIP_MESCs_Mouse1.39162070
77NANOG_16153702_ChIP-ChIP_HESCs_Human1.37641882
78SMAD1_18555785_ChIP-Seq_MESCs_Mouse1.37598270
79P300_27058665_Chip-Seq_ZR-75-30cells_Human1.36867103
80* RNF2_16625203_ChIP-ChIP_MESCs_Mouse1.36371313
81KDM2B_26808549_Chip-Seq_SUP-B15_Human1.35895097
82SALL4_18804426_ChIP-ChIP_MESCs_Mouse1.34840530
83NOTCH1_17114293_ChIP-ChIP_T-ALL_Human1.34059730
84FOXO3_23340844_ChIP-Seq_DLD1_Human1.32826092
85CREB1_23762244_ChIP-Seq_HIPPOCAMPUS_Rat1.27509543
86KLF4_18555785_ChIP-Seq_MESCs_Mouse1.27459455
87EZH2_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse1.26232055
88ESR1_20079471_ChIP-ChIP_T-47D_Human1.25136912
89* CBX2_27304074_Chip-Seq_ESCs_Mouse1.23670411
90ATF3_27146783_Chip-Seq_COLON_Human1.23382460
91TCFAP2C_20176728_ChIP-ChIP_TROPHOBLAST_STEM_CELLS_Mouse1.23340570
92* NR0B1_18358816_ChIP-ChIP_MESCs_Mouse1.23105034
93E2F1_21310950_ChIP-Seq_MCF-7_Human1.21537429
94* KLF4_19030024_ChIP-ChIP_MESCs_Mouse1.20839061
95CREB1_20920259_ChIP-Seq_GC1-SPG_Mouse1.19764361
96ZNF652_21678463_ChIP-ChIP_ZR75-1_Human1.19629354
97BRD4_25478319_ChIP-Seq_HGPS_Human1.19532742
98OCT4_18692474_ChIP-Seq_MEFs_Mouse1.18761233
99NCOR1_26117541_ChIP-Seq_K562_Human1.18581965
100CEBPB_24764292_ChIP-Seq_MC3T3_Mouse1.16973424
101CEBPB_21427703_ChIP-Seq_3T3-L1_Mouse1.16011254
102SMARCA4_20176728_ChIP-ChIP_TSCs_Mouse1.15441727
103NKX2-5_21415370_ChIP-Seq_HL-1_Mouse1.14950463
104NELFA_20434984_ChIP-Seq_ESCs_Mouse1.14640222
105CHD1_26751641_Chip-Seq_LNCaP_Human1.14431501
106HSF1_23293686_ChIP-Seq_STHDH_STRIATAL_Mouse1.13877710
107ETS1_20019798_ChIP-Seq_JURKAT_Human1.13865651
108* FOXM1_25889361_ChIP-Seq_OE33_AND_U2OS_Human1.13750556
109* CREB1_26743006_Chip-Seq_LNCaP-abl_Human1.13576826
110* SUZ12_16625203_ChIP-ChIP_MESCs_Mouse1.13336205
111CTCF_27219007_Chip-Seq_ERYTHROID_Human1.12636634
112SREBP1_19666523_ChIP-Seq_LIVER_Mouse1.11382439
113MYC_22102868_ChIP-Seq_BL_Human1.11031020
114CREB1_26743006_Chip-Seq_LNCaP_Human1.10825106
115POU5F1_18555785_ChIP-Seq_MESCs_Mouse1.10144273
116LXR_22292898_ChIP-Seq_THP-1_Human1.09895361
117SA1_27219007_Chip-Seq_ERYTHROID_Human1.09708340
118GABP_19822575_ChIP-Seq_HepG2_Human1.09664734
119MYCN_27167114_Chip-Seq_NEUROBLASTOMA_Human1.08334608
120FOXM1_26100407_CHIP-SEQ_Hek293_flp-in_Human1.07490173
121E2F4_17652178_ChIP-ChIP_JURKAT_Human1.07316607
122KDM5A_27292631_Chip-Seq_BREAST_Human1.07244096
123* JARID2_20064375_ChIP-Seq_MESCs_Mouse1.07187290
124SMC1_22415368_ChIP-Seq_MEFs_Mouse1.07143972
125DMRT1_23473982_ChIP-Seq_TESTES_Mouse1.07126096
126* SUZ12_18692474_ChIP-Seq_MEFs_Mouse1.06947293
127POU5F1_16153702_ChIP-ChIP_HESCs_Human1.06671954
128ELF3_26769127_Chip-Seq_PDAC-Cell_line_Human1.06638156
129EKLF_21900194_ChIP-Seq_ERYTHROCYTE_Mouse1.05768863
130NANOG_18692474_ChIP-Seq_MEFs_Mouse1.05249500
131ATF3_23680149_ChIP-Seq_GBM1-GSC_Human1.05110359
132* TRIM28_19339689_ChIP-ChIP_MESCs_Mouse1.04338552
133TCF7_22412390_ChIP-Seq_EML_Mouse1.02962606
134KDM2B_26808549_Chip-Seq_K562_Human1.02661238
135E2F1_18555785_ChIP-Seq_MESCs_Mouse1.02508925
136KLF4_26769127_Chip-Seq_PDAC-Cell_line_Human1.02479033
137* RING1B_27294783_Chip-Seq_NPCs_Mouse1.02307365
138POU5F1_16518401_ChIP-PET_MESCs_Mouse1.00984225
139CTCF_18555785_ChIP-Seq_MESCs_Mouse0.99752122
140TFAP2A_17053090_ChIP-ChIP_MCF-7_Human0.99372286
141MYC_18555785_ChIP-Seq_MESCs_Mouse0.99325798
142* RNF2_18974828_ChIP-Seq_MESCs_Mouse0.99118605
143* EZH2_18974828_ChIP-Seq_MESCs_Mouse0.99118605
144SOX2_18692474_ChIP-Seq_MEFs_Mouse0.98821954
145* SMAD3_18955504_ChIP-ChIP_HaCaT_Human0.97731245
146* SMAD2_18955504_ChIP-ChIP_HaCaT_Human0.97731245
147NANOG_18358816_ChIP-ChIP_MESCs_Mouse0.97170805
148MYC_19079543_ChIP-ChIP_MESCs_Mouse0.96780740
149KDM2B_26808549_Chip-Seq_SIL-ALL_Human0.96511048
150EOMES_20176728_ChIP-ChIP_TSCs_Mouse0.95596445
151* PHC1_16625203_ChIP-ChIP_MESCs_Mouse0.94560149
152MYBL1_21750041_ChIP-ChIP_SPERMATOCYTES_Mouse0.94011674
153FOXP2_23625967_ChIP-Seq_PFSK-1_AND_SK-N-MC_Human0.93950678
154UBF1/2_26484160_Chip-Seq_HMECs_Human0.92035689

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0008438_abnormal_cutaneous_collagen4.96007818
2MP0002254_reproductive_system_inflammat3.92813480
3MP0003705_abnormal_hypodermis_morpholog3.78306232
4MP0005503_abnormal_tendon_morphology3.16005333
5MP0009053_abnormal_anal_canal3.09506522
6MP0010030_abnormal_orbit_morphology2.83657859
7MP0006054_spinal_hemorrhage2.55315232
8MP0002877_abnormal_melanocyte_morpholog2.51590159
9MP0003122_maternal_imprinting2.44766276
10MP0003385_abnormal_body_wall2.37099167
11MP0005275_abnormal_skin_tensile2.33927215
12MP0003123_paternal_imprinting2.31573443
13MP0000537_abnormal_urethra_morphology2.29824893
14MP0004272_abnormal_basement_membrane2.19376422
15MP0010352_gastrointestinal_tract_polyps2.18550342
16MP0002932_abnormal_joint_morphology2.17204361
17* MP0003942_abnormal_urinary_system2.07005551
18MP0003315_abnormal_perineum_morphology2.05988662
19MP0005171_absent_coat_pigmentation2.03403804
20* MP0009250_abnormal_appendicular_skeleto2.00773690
21MP0003279_aneurysm1.93949405
22MP0005508_abnormal_skeleton_morphology1.93838336
23MP0005623_abnormal_meninges_morphology1.89964144
24MP0001849_ear_inflammation1.88287443
25MP0005257_abnormal_intraocular_pressure1.87176131
26MP0004233_abnormal_muscle_weight1.83361707
27MP0004264_abnormal_extraembryonic_tissu1.82464563
28MP0005076_abnormal_cell_differentiation1.80807670
29MP0003111_abnormal_nucleus_morphology1.76681931
30MP0000049_abnormal_middle_ear1.73086556
31MP0003121_genomic_imprinting1.71874093
32MP0003937_abnormal_limbs/digits/tail_de1.69238957
33MP0004858_abnormal_nervous_system1.63118901
34* MP0000534_abnormal_ureter_morphology1.61915447
35MP0002282_abnormal_trachea_morphology1.61447942
36MP0000428_abnormal_craniofacial_morphol1.60372779
37MP0002249_abnormal_larynx_morphology1.58960908
38MP0003566_abnormal_cell_adhesion1.57611161
39MP0005023_abnormal_wound_healing1.57232912
40MP0001958_emphysema1.56424462
41MP0000733_abnormal_muscle_development1.54632419
42MP0000516_abnormal_urinary_system1.54088946
43MP0005367_renal/urinary_system_phenotyp1.54088946
44MP0003938_abnormal_ear_development1.53646723
45MP0000013_abnormal_adipose_tissue1.52447783
46MP0000767_abnormal_smooth_muscle1.51790692
47MP0000749_muscle_degeneration1.51598216
48MP0001346_abnormal_lacrimal_gland1.44604896
49* MP0002114_abnormal_axial_skeleton1.44399903
50MP0000003_abnormal_adipose_tissue1.43078856
51* MP0002160_abnormal_reproductive_system1.42237968
52MP0000751_myopathy1.39091681
53MP0003693_abnormal_embryo_hatching1.38868189
54MP0001661_extended_life_span1.38504532
55* MP0002115_abnormal_skeleton_extremities1.37808402
56MP0000163_abnormal_cartilage_morphology1.32965053
57MP0003755_abnormal_palate_morphology1.32735284
58* MP0002109_abnormal_limb_morphology1.31262020
59MP0003935_abnormal_craniofacial_develop1.29801350
60MP0000762_abnormal_tongue_morphology1.28074035
61MP0002837_dystrophic_cardiac_calcinosis1.27882117
62MP0001542_abnormal_bone_strength1.27196879
63MP0008932_abnormal_embryonic_tissue1.27036335
64MP0004185_abnormal_adipocyte_glucose1.27019583
65MP0003283_abnormal_digestive_organ1.21340635
66MP0002234_abnormal_pharynx_morphology1.21167875
67MP0000681_abnormal_thyroid_gland1.19086460
68MP0002233_abnormal_nose_morphology1.15612158
69MP0000678_abnormal_parathyroid_gland1.14468500
70MP0003011_delayed_dark_adaptation1.12912641
71MP0000432_abnormal_head_morphology1.11201519
72MP0002113_abnormal_skeleton_development1.09809573
73MP0002108_abnormal_muscle_morphology1.09808277
74MP0004883_abnormal_blood_vessel1.09389343
75MP0002116_abnormal_craniofacial_bone1.07143272
76MP0005187_abnormal_penis_morphology1.06611554
77MP0003077_abnormal_cell_cycle1.06563283
78MP0005330_cardiomyopathy1.06487608
79MP0005670_abnormal_white_adipose1.06028906
80MP0000538_abnormal_urinary_bladder1.05386483
81MP0002092_abnormal_eye_morphology1.04670588
82MP0005380_embryogenesis_phenotype1.04219408
83MP0001672_abnormal_embryogenesis/_devel1.04219408
84MP0010368_abnormal_lymphatic_system1.04032200
85MP0005248_abnormal_Harderian_gland1.02823425
86MP0002085_abnormal_embryonic_tissue1.02805852
87MP0004957_abnormal_blastocyst_morpholog0.99079621
88MP0010094_abnormal_chromosome_stability0.98697420
89MP0003115_abnormal_respiratory_system0.98308015
90MP0002009_preneoplasia0.97794007
91MP0002925_abnormal_cardiovascular_devel0.97516680
92* MP0002111_abnormal_tail_morphology0.96822255
93MP0003941_abnormal_skin_development0.96284180
94MP0000750_abnormal_muscle_regeneration0.95983411
95MP0002269_muscular_atrophy0.95242886
96MP0003567_abnormal_fetal_cardiomyocyte0.95026446
97MP0002086_abnormal_extraembryonic_tissu0.94974053
98MP0001270_distended_abdomen0.94593749
99MP0003045_fibrosis0.94251601
100MP0002088_abnormal_embryonic_growth/wei0.93704728
101MP0002060_abnormal_skin_morphology0.93526520
102MP0003984_embryonic_growth_retardation0.91859606
103MP0004197_abnormal_fetal_growth/weight/0.91098298
104MP0000858_altered_metastatic_potential0.89362748
105MP0005164_abnormal_response_to0.88169695
106MP0004087_abnormal_muscle_fiber0.88078507
107MP0002896_abnormal_bone_mineralization0.87777605
108MP0003091_abnormal_cell_migration0.87415377
109MP0009384_cardiac_valve_regurgitation0.85721376
110MP0002697_abnormal_eye_size0.84960739
111MP0005390_skeleton_phenotype0.84915135
112MP0001293_anophthalmia0.84793848
113MP0002084_abnormal_developmental_patter0.84309321
114MP0010234_abnormal_vibrissa_follicle0.83638517
115MP0001614_abnormal_blood_vessel0.83518057
116MP0008007_abnormal_cellular_replicative0.83341536
117MP0005197_abnormal_uvea_morphology0.82107438
118MP0010307_abnormal_tumor_latency0.82010548
119MP0005375_adipose_tissue_phenotype0.81611057
120MP0001664_abnormal_digestion0.81180406
121MP0003119_abnormal_digestive_system0.79766509
122MP0000350_abnormal_cell_proliferation0.78852935
123MP0001730_embryonic_growth_arrest0.77834775
124MP0003890_abnormal_embryonic-extraembry0.76088669
125MP0001299_abnormal_eye_distance/0.73807310
126MP0001879_abnormal_lymphatic_vessel0.73497787
127MP0005394_taste/olfaction_phenotype0.72522140
128MP0005499_abnormal_olfactory_system0.72522140
129MP0001243_abnormal_dermal_layer0.72359084
130MP0002089_abnormal_postnatal_growth/wei0.72179544
131MP0000462_abnormal_digestive_system0.71859470
132MP0003936_abnormal_reproductive_system0.71061851
133MP0000759_abnormal_skeletal_muscle0.70970299
134MP0009780_abnormal_chondrocyte_physiolo0.70952416
135MP0001348_abnormal_lacrimal_gland0.70518053
136MP0002177_abnormal_outer_ear0.70182329
137MP0001697_abnormal_embryo_size0.69100419
138MP0000627_abnormal_mammary_gland0.68687073

Predicted human phenotypes

RankGene SetZ-score
1Premature rupture of membranes (HP:0001788)5.20935267
2Protrusio acetabuli (HP:0003179)4.42008911
3Aortic dissection (HP:0002647)4.16835018
4Aortic aneurysm (HP:0004942)4.02141596
5Abnormal umbilical cord blood vessels (HP:0011403)3.78882614
6Single umbilical artery (HP:0001195)3.78882614
7Abnormality of the fetal cardiovascular system (HP:0010948)3.78882614
8Short 5th finger (HP:0009237)3.57713034
9Mesomelia (HP:0003027)3.57679530
10Hepatoblastoma (HP:0002884)3.36447521
11Aplasia/Hypoplasia of the 5th finger (HP:0006262)3.27885098
12Shallow orbits (HP:0000586)3.16308841
13Abnormality of the umbilical cord (HP:0010881)3.15266755
14Short middle phalanx of the 5th finger (HP:0004220)3.15176993
15Bilateral microphthalmos (HP:0007633)3.12389610
16Cerebral aneurysm (HP:0004944)3.10036300
17Ankle contracture (HP:0006466)3.08049813
18Spinal rigidity (HP:0003306)3.02193124
19Septate vagina (HP:0001153)2.96669892
20Abnormality of the distal phalanx of the thumb (HP:0009617)2.92735571
21Abnormality of the phalanges of the hallux (HP:0010057)2.91239832
22Cervical subluxation (HP:0003308)2.89426386
23Renal duplication (HP:0000075)2.88062150
24Broad metatarsal (HP:0001783)2.84229748
25Rectal prolapse (HP:0002035)2.82337225
26Abnormality of the 4th metacarpal (HP:0010012)2.81256891
27Sparse lateral eyebrow (HP:0005338)2.80301942
28Peritonitis (HP:0002586)2.78163358
29Genu recurvatum (HP:0002816)2.74736210
30Elbow flexion contracture (HP:0002987)2.70996465
31Abnormality of the distal phalanges of the toes (HP:0010182)2.70335152
32Short clavicles (HP:0000894)2.63658055
33Soft skin (HP:0000977)2.59856873
34Mitral valve prolapse (HP:0001634)2.59606425
35Absent frontal sinuses (HP:0002688)2.57007842
36Broad thumb (HP:0011304)2.53941046
37Abnormality of the 2nd finger (HP:0004100)2.51776949
38Nonimmune hydrops fetalis (HP:0001790)2.50258962
39Increased connective tissue (HP:0009025)2.48988785
40Short hallux (HP:0010109)2.47216204
41Biconcave vertebral bodies (HP:0004586)2.45034687
42Abnormality of the calcaneus (HP:0008364)2.44618879
43Calcaneovalgus deformity (HP:0001848)2.44233141
44Deformed tarsal bones (HP:0008119)2.43653618
45Increased variability in muscle fiber diameter (HP:0003557)2.42830124
46Wide anterior fontanel (HP:0000260)2.41106280
47Abnormal ventriculo-arterial connection (HP:0011563)2.40719069
48Transposition of the great arteries (HP:0001669)2.40719069
49Abnormal connection of the cardiac segments (HP:0011545)2.40719069
50Absent phalangeal crease (HP:0006109)2.37192133
51Blue sclerae (HP:0000592)2.35949196
52Abnormal cartilage morphology (HP:0002763)2.35921018
53Aplasia/Hypoplasia of the clavicles (HP:0006710)2.34625257
54Aplasia/Hypoplasia of the 4th metacarpal (HP:0010042)2.33900056
55Short 4th metacarpal (HP:0010044)2.33900056
56Aplasia/Hypoplasia of the middle phalanx of the 5th finger (HP:0009161)2.33834888
57Broad distal phalanx of finger (HP:0009836)2.33812376
58Neoplasm of the heart (HP:0100544)2.31609762
59Wrist flexion contracture (HP:0001239)2.31462223
60* Ulnar bowing (HP:0003031)2.30269690
61Fused cervical vertebrae (HP:0002949)2.29370770
62Vertebral compression fractures (HP:0002953)2.28855239
63Dilatation of the ascending aorta (HP:0005111)2.27652022
64Spondylolisthesis (HP:0003302)2.27003516
65Aplasia/Hypoplasia of the hallux (HP:0008362)2.26847404
66Short middle phalanx of finger (HP:0005819)2.26462951
67Broad toe (HP:0001837)2.26129121
68Deviation of the hallux (HP:0010051)2.25661576
69Tarsal synostosis (HP:0008368)2.25598197
70Arterial tortuosity (HP:0005116)2.25477001
71Coronal craniosynostosis (HP:0004440)2.24319925
72Breast hypoplasia (HP:0003187)2.22213898
73Follicular hyperkeratosis (HP:0007502)2.19550896
74Multiple enchondromatosis (HP:0005701)2.18838221
75Achilles tendon contracture (HP:0001771)2.18664890
76Aplasia/Hypoplasia of the frontal sinuses (HP:0009119)2.18552035
77Short humerus (HP:0005792)2.18425395
78Partial duplication of the phalanx of hand (HP:0009999)2.17672040
79Mildly elevated creatine phosphokinase (HP:0008180)2.17457549
80Redundant skin (HP:0001582)2.17436584
81Abnormality of dentin (HP:0010299)2.17435175
82Trismus (HP:0000211)2.15815818
83Vascular tortuosity (HP:0004948)2.15787261
84Reduced subcutaneous adipose tissue (HP:0003758)2.14686154
85Aplasia/Hypoplasia of the phalanges of the 5th finger (HP:0009376)2.14518195
86Abnormal delivery (HP:0001787)2.14255514
87Abnormality of skeletal muscle fiber size (HP:0012084)2.13790452
88Type 1 muscle fiber predominance (HP:0003803)2.10846560
89Abnormal ossification of hand bones (HP:0005921)2.10769298
90Synostosis involving bones of the lower limbs (HP:0009138)2.10195952
91Synostosis involving bones of the feet (HP:0009140)2.10195952
92Broad long bones (HP:0005622)2.09368397
93Mitral regurgitation (HP:0001653)2.08821145
94Rib fusion (HP:0000902)2.08657039
95Round ear (HP:0100830)2.07103808
96Broad phalanges of the hand (HP:0009768)2.06635848
97Tracheal stenosis (HP:0002777)2.06405127
98Broad phalanx (HP:0006009)2.06350403
99Carpal synostosis (HP:0009702)2.04921330
100Generalized amyotrophy (HP:0003700)2.03811168
101Synostosis of carpal bones (HP:0005048)2.03467651
102Aplasia/hypoplasia of the humerus (HP:0006507)2.02936616
103Camptodactyly of toe (HP:0001836)2.02618812
104Aneurysm (HP:0002617)2.02349390
105Osteolytic defects of the hand bones (HP:0009699)2.01243711
106Osteolytic defects of the phalanges of the hand (HP:0009771)2.01243711
107Symphalangism affecting the phalanges of the hand (HP:0009773)2.01037456
108Neonatal short-limb short stature (HP:0008921)2.00370553
109Persistence of primary teeth (HP:0006335)1.99957124
110Aplasia/Hypoplasia of the 1st metacarpal (HP:0010026)1.99355709
111Short 1st metacarpal (HP:0010034)1.99355709
112Progressive muscle weakness (HP:0003323)1.98477825
113Preaxial foot polydactyly (HP:0001841)1.97855470
114Broad finger (HP:0001500)1.97757657
115Abnormality of carpal bone ossification (HP:0006257)1.97322292
116Selective tooth agenesis (HP:0001592)1.96288502
117Ulnar deviation of finger (HP:0009465)1.95739753
118Bladder diverticulum (HP:0000015)1.93099914
119Wormian bones (HP:0002645)1.92435052
120Abnormality of the middle phalanges of the toes (HP:0010183)1.92139615
121Aplasia/Hypoplasia of the middle phalanges of the hand (HP:0009843)1.91070506
122Ureteral obstruction (HP:0006000)1.90415864
123Aplasia of the musculature (HP:0100854)1.90032607
124Abnormality of the middle phalanx of the 5th finger (HP:0004219)1.89900126
125Spinal cord lesions (HP:0100561)1.89190234
126Syringomyelia (HP:0003396)1.89190234
127Synostosis involving bones of the hand (HP:0004278)1.89009180
128Joint laxity (HP:0001388)1.88307746
129Scapular winging (HP:0003691)1.88055774
130Hallux valgus (HP:0001822)1.87422460
131Atrophic scars (HP:0001075)1.87112415
132Abnormality of the Achilles tendon (HP:0005109)1.86916224
133Abnormal finger flexion creases (HP:0006143)1.84637645
134Abnormalities of placenta or umbilical cord (HP:0001194)1.84614692
135Short nail (HP:0001799)1.84183122
136Slender build (HP:0001533)1.83942620
137Hyperextensible skin (HP:0000974)1.83593147
138Fragile skin (HP:0001030)1.83023110
139Delayed cranial suture closure (HP:0000270)1.82416258
140Premature skin wrinkling (HP:0100678)1.82414507
141Aplasia/Hypoplasia involving the sinuses (HP:0009120)1.82005767
142Ureteral stenosis (HP:0000071)1.81634116
143Abnormality of the 1st metacarpal (HP:0010009)1.81031919
144Nephroblastoma (Wilms tumor) (HP:0002667)1.80782860
145Abnormal number of incisors (HP:0011064)1.80262124
146Aortic regurgitation (HP:0001659)1.78818949
147Bowel diverticulosis (HP:0005222)1.76840971
148Hypoplasia of the iris (HP:0007676)1.75925566
149Breech presentation (HP:0001623)1.74170307

Predicted kinase interactions (KEA)

RankGene SetZ-score
1ERN14.93511676
2CDK124.90420203
3TTN3.63696340
4TRIB33.36091598
5IRAK33.32891943
6DDR23.15270356
7TGFBR23.03962080
8NME22.94603498
9LATS12.85924545
10PDGFRA2.81218450
11LATS22.40495529
12BUB12.38729144
13MYLK2.37198662
14MAP3K102.35339097
15PKN22.25588659
16PAK42.10947371
17SMG12.10676559
18GRK51.91672440
19PAK21.75844582
20STK101.69567448
21GRK61.64384465
22TYRO31.63334164
23PRKD31.57047655
24NEK91.39539059
25TTK1.39517255
26TESK11.39438355
27WNK11.37457124
28MOS1.35766803
29CDK81.33665690
30EPHB21.32629442
31CSF1R1.31992751
32NTRK11.30978130
33RIPK11.30686647
34EEF2K1.30582048
35BMX1.30085897
36PTK21.26888716
37PTK61.26269452
38CHEK21.20570616
39LRRK21.19039471
40DMPK1.16624196
41MELK1.16435871
42PIK3CG1.15332263
43STK31.15157840
44CAMK1G1.14784767
45MET1.14144101
46CAMK1D1.09214213
47PRKG21.08042669
48LIMK11.05572574
49KDR1.05456750
50PRKD21.03025790
51SIK11.00532627
52MAPK70.99464578
53ABL20.99040233
54MAP2K20.98797944
55AKT30.95570904
56MTOR0.92871314
57MATK0.90274480
58PIM20.89802279
59FER0.89772619
60PAK10.89534432
61CDK70.88981859
62RPS6KB20.88819540
63FGFR10.87697163
64MAPKAPK30.86043195
65PRPF4B0.83726730
66AKT20.78892953
67AURKA0.78747095
68MUSK0.76952909
69ALK0.76242020
70PDPK10.75567857
71STK38L0.74860805
72GRK10.74284518
73PLK40.74094974
74TESK20.73774744
75CDK40.72073817
76IRAK20.71630143
77MAP3K80.70060421
78ILK0.69836045
79ZAK0.69427322
80PAK30.69318072
81TLK10.69155063
82FGFR30.67509745
83RPS6KC10.67321409
84RPS6KL10.67321409
85FLT30.67098194
86PDGFRB0.66155624
87RPS6KA20.65250594
88MST1R0.64912425
89STK40.63766073
90MAPK110.63124064
91PDK20.61866141
92LMTK20.60841269
93ERBB30.57441178
94NEK20.57080637
95BRSK10.56917874
96MKNK10.56727031
97ADRBK10.56615689
98RPS6KA60.54801106
99CDK90.51891266
100ATR0.50480397
101CAMK40.50157024
102FGFR20.49605252
103CSNK1A1L0.48509454
104TRPM70.48038099
105KSR20.47496866
106TGFBR10.47284863
107NEK10.46899425
108WEE10.45428980
109ERBB20.44323809
110PLK10.43804146
111MAP2K30.43590146
112MAP3K70.43467158
113ROCK10.42727534
114ADRBK20.42025206
115DAPK30.41351429
116CAMK2G0.40472789
117PTK2B0.40277106
118PBK0.39991044
119BRAF0.39608567
120PRKCI0.38634533
121SRC0.38327352
122ROCK20.38191356
123IGF1R0.37967080
124BRSK20.37816726
125RPS6KA40.37493528
126ARAF0.36486659
127MAP3K60.35695765
128AURKB0.35183083
129CDK60.35105230
130PASK0.34891508
131SCYL20.34778855
132MAPK120.34654082
133CHEK10.34636109
134TAOK20.34085997
135STK380.33260274
136ICK0.31360222
137MAP2K10.31057846
138GSK3A0.30908971
139INSR0.30800922
140CDC42BPA0.30652996
141MARK20.30142345
142MAPKAPK20.30126535
143EPHA20.29497222
144EPHB10.29277411
145CDC70.28487098

Predicted pathways (KEGG)

RankGene SetZ-score
1Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006034.17843424
2Sulfur relay system_Homo sapiens_hsa041223.51935538
3ECM-receptor interaction_Homo sapiens_hsa045122.62537374
4DNA replication_Homo sapiens_hsa030302.57120854
5Proteoglycans in cancer_Homo sapiens_hsa052052.48255674
6Basal cell carcinoma_Homo sapiens_hsa052172.39944437
7Focal adhesion_Homo sapiens_hsa045102.37598758
8Hippo signaling pathway_Homo sapiens_hsa043902.17400253
9One carbon pool by folate_Homo sapiens_hsa006702.10396201
10TGF-beta signaling pathway_Homo sapiens_hsa043502.05446380
11Glycosaminoglycan degradation_Homo sapiens_hsa005312.04333274
12Bladder cancer_Homo sapiens_hsa052191.93236220
13Ribosome_Homo sapiens_hsa030101.91266584
14Adherens junction_Homo sapiens_hsa045201.83694203
15Hedgehog signaling pathway_Homo sapiens_hsa043401.80247822
16MicroRNAs in cancer_Homo sapiens_hsa052061.78531778
17Arrhythmogenic right ventricular cardiomyopathy (ARVC)_Homo sapiens_hsa054121.63738969
18Protein processing in endoplasmic reticulum_Homo sapiens_hsa041411.59747511
19Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa045501.59287670
20Pyrimidine metabolism_Homo sapiens_hsa002401.58945242
21RNA polymerase_Homo sapiens_hsa030201.58730937
22Small cell lung cancer_Homo sapiens_hsa052221.57970180
23Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004001.56141776
24Arachidonic acid metabolism_Homo sapiens_hsa005901.55382379
25Chronic myeloid leukemia_Homo sapiens_hsa052201.54283573
26Galactose metabolism_Homo sapiens_hsa000521.54202558
27Fructose and mannose metabolism_Homo sapiens_hsa000511.52061634
28Bacterial invasion of epithelial cells_Homo sapiens_hsa051001.50859211
29Base excision repair_Homo sapiens_hsa034101.48619951
30Thyroid cancer_Homo sapiens_hsa052161.47141305
31Hypertrophic cardiomyopathy (HCM)_Homo sapiens_hsa054101.46515269
32Regulation of actin cytoskeleton_Homo sapiens_hsa048101.41292131
33Protein digestion and absorption_Homo sapiens_hsa049741.40437175
34Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate_Homo sapiens_hsa005321.37343837
35AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa049331.37001178
36Longevity regulating pathway - mammal_Homo sapiens_hsa042111.36425785
37Longevity regulating pathway - multiple species_Homo sapiens_hsa042131.34157089
38Pathways in cancer_Homo sapiens_hsa052001.32484288
39Tight junction_Homo sapiens_hsa045301.31929085
40mTOR signaling pathway_Homo sapiens_hsa041501.30852809
41Dilated cardiomyopathy_Homo sapiens_hsa054141.30698060
42Leukocyte transendothelial migration_Homo sapiens_hsa046701.30132022
43Amoebiasis_Homo sapiens_hsa051461.27453415
44PI3K-Akt signaling pathway_Homo sapiens_hsa041511.26150354
45Pancreatic cancer_Homo sapiens_hsa052121.25050299
46Nucleotide excision repair_Homo sapiens_hsa034201.23020018
47Rap1 signaling pathway_Homo sapiens_hsa040151.16552160
48Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa005201.15564969
49Central carbon metabolism in cancer_Homo sapiens_hsa052301.15368028
50Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001301.14704834
51Cell cycle_Homo sapiens_hsa041101.14479073
52Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005121.14173110
53* Transcriptional misregulation in cancer_Homo sapiens_hsa052021.13516980
54Wnt signaling pathway_Homo sapiens_hsa043101.09153499
55Sulfur metabolism_Homo sapiens_hsa009201.08416177
56Vitamin B6 metabolism_Homo sapiens_hsa007501.08067985
57Colorectal cancer_Homo sapiens_hsa052101.06943993
58Other glycan degradation_Homo sapiens_hsa005111.05884105
59Vascular smooth muscle contraction_Homo sapiens_hsa042701.04175457
60HTLV-I infection_Homo sapiens_hsa051660.98807240
61Biosynthesis of amino acids_Homo sapiens_hsa012300.94487218
62Citrate cycle (TCA cycle)_Homo sapiens_hsa000200.94238561
63Prostate cancer_Homo sapiens_hsa052150.93887223
64Melanoma_Homo sapiens_hsa052180.92491214
65p53 signaling pathway_Homo sapiens_hsa041150.92064318
66Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030080.92044782
67Purine metabolism_Homo sapiens_hsa002300.88439385
68Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa005340.85798681
69VEGF signaling pathway_Homo sapiens_hsa043700.85608258
70Renin-angiotensin system_Homo sapiens_hsa046140.84597081
71Mismatch repair_Homo sapiens_hsa034300.84522107
72Selenocompound metabolism_Homo sapiens_hsa004500.84077477
73RNA transport_Homo sapiens_hsa030130.83891846
74Folate biosynthesis_Homo sapiens_hsa007900.83798006
75Pathogenic Escherichia coli infection_Homo sapiens_hsa051300.83706627
76Regulation of lipolysis in adipocytes_Homo sapiens_hsa049230.82893262
77Endometrial cancer_Homo sapiens_hsa052130.79599380
78cGMP-PKG signaling pathway_Homo sapiens_hsa040220.76126429
79Non-small cell lung cancer_Homo sapiens_hsa052230.75718036
80Ubiquitin mediated proteolysis_Homo sapiens_hsa041200.75356756
81Apoptosis_Homo sapiens_hsa042100.75088945
82Viral myocarditis_Homo sapiens_hsa054160.74188670
83Viral carcinogenesis_Homo sapiens_hsa052030.73229347
84Phospholipase D signaling pathway_Homo sapiens_hsa040720.71760149
85Sphingolipid metabolism_Homo sapiens_hsa006000.71496158
86Glycolysis / Gluconeogenesis_Homo sapiens_hsa000100.71393288
87Cysteine and methionine metabolism_Homo sapiens_hsa002700.71392736
88Pentose phosphate pathway_Homo sapiens_hsa000300.70846153
89HIF-1 signaling pathway_Homo sapiens_hsa040660.70251924
90Glioma_Homo sapiens_hsa052140.68958230
91Melanogenesis_Homo sapiens_hsa049160.66319162
92Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa009700.65500929
93Neurotrophin signaling pathway_Homo sapiens_hsa047220.64569352
94Other types of O-glycan biosynthesis_Homo sapiens_hsa005140.63904420
95Toxoplasmosis_Homo sapiens_hsa051450.62712767
96Axon guidance_Homo sapiens_hsa043600.62333261
97Insulin signaling pathway_Homo sapiens_hsa049100.62021355
98Malaria_Homo sapiens_hsa051440.61267690
99alpha-Linolenic acid metabolism_Homo sapiens_hsa005920.61213813
100Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa049610.60758179
101mRNA surveillance pathway_Homo sapiens_hsa030150.60586234
102Thyroid hormone synthesis_Homo sapiens_hsa049180.60490663
103Thyroid hormone signaling pathway_Homo sapiens_hsa049190.60417424
104Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006040.59979265
105Platelet activation_Homo sapiens_hsa046110.59551842
106Fc gamma R-mediated phagocytosis_Homo sapiens_hsa046660.59295977
107Homologous recombination_Homo sapiens_hsa034400.58828412
108Cyanoamino acid metabolism_Homo sapiens_hsa004600.57952181
109Pentose and glucuronate interconversions_Homo sapiens_hsa000400.57745140
110Notch signaling pathway_Homo sapiens_hsa043300.57553186
111Pyruvate metabolism_Homo sapiens_hsa006200.56565788
112Fanconi anemia pathway_Homo sapiens_hsa034600.56286198
113Lysosome_Homo sapiens_hsa041420.55464320
114Progesterone-mediated oocyte maturation_Homo sapiens_hsa049140.54236676
115Ras signaling pathway_Homo sapiens_hsa040140.54126712
116Phenylalanine metabolism_Homo sapiens_hsa003600.54103231
117Lysine degradation_Homo sapiens_hsa003100.53734691
118Shigellosis_Homo sapiens_hsa051310.53434596
119Glutathione metabolism_Homo sapiens_hsa004800.52965924
120FoxO signaling pathway_Homo sapiens_hsa040680.52674808
121Adipocytokine signaling pathway_Homo sapiens_hsa049200.52351310
122Arginine and proline metabolism_Homo sapiens_hsa003300.51057256
123Salmonella infection_Homo sapiens_hsa051320.50400664
124Acute myeloid leukemia_Homo sapiens_hsa052210.50277981
125Fatty acid biosynthesis_Homo sapiens_hsa000610.50256636
126Chagas disease (American trypanosomiasis)_Homo sapiens_hsa051420.49916787
127Leishmaniasis_Homo sapiens_hsa051400.49662998
128Glucagon signaling pathway_Homo sapiens_hsa049220.47003134
129Linoleic acid metabolism_Homo sapiens_hsa005910.46618393
130Renal cell carcinoma_Homo sapiens_hsa052110.45862793
131N-Glycan biosynthesis_Homo sapiens_hsa005100.45780240
132GnRH signaling pathway_Homo sapiens_hsa049120.45717354
133Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005330.43817641
134Complement and coagulation cascades_Homo sapiens_hsa046100.43575573
135AMPK signaling pathway_Homo sapiens_hsa041520.42521758
136Gap junction_Homo sapiens_hsa045400.41602810
137Insulin resistance_Homo sapiens_hsa049310.40696901
138Spliceosome_Homo sapiens_hsa030400.40609812

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