HOXA2

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: In vertebrates, the genes encoding the class of transcription factors called homeobox genes are found in clusters named A, B, C, and D on four separate chromosomes. Expression of these proteins is spatially and temporally regulated during embryonic development. This gene is part of the A cluster on chromosome 7 and encodes a DNA-binding transcription factor which may regulate gene expression, morphogenesis, and differentiation. The encoded protein may be involved in the placement of hindbrain segments in the proper location along the anterior-posterior axis during development. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1hemidesmosome assembly (GO:0031581)6.81299067
2outer ear morphogenesis (GO:0042473)6.20298606
3mesenchymal-epithelial cell signaling (GO:0060638)5.71491612
4regulation of single stranded viral RNA replication via double stranded DNA intermediate (GO:00450915.67444481
5regulation of mitochondrial translation (GO:0070129)5.45438505
6cranial nerve structural organization (GO:0021604)5.37117772
7viral transcription (GO:0019083)5.10750778
8peptidyl-arginine omega-N-methylation (GO:0035247)4.95788767
9peptidyl-arginine N-methylation (GO:0035246)4.89119341
10peptidyl-arginine methylation (GO:0018216)4.89119341
11negative regulation of type 2 immune response (GO:0002829)4.89102206
12translational termination (GO:0006415)4.88405700
13regulation of acrosome reaction (GO:0060046)4.85764900
14righting reflex (GO:0060013)4.76806479
15respiratory tube development (GO:0030323)4.74340165
16dosage compensation (GO:0007549)4.58338445
17response to xenobiotic stimulus (GO:0009410)4.52835260
18cartilage morphogenesis (GO:0060536)4.49173055
19G-protein coupled receptor signaling pathway coupled to cGMP nucleotide second messenger (GO:00071994.48910321
20ribosomal small subunit assembly (GO:0000028)4.40222181
21chondrocyte proliferation (GO:0035988)4.36043603
22negative regulation of keratinocyte proliferation (GO:0010839)4.35252548
23negative regulation of viral entry into host cell (GO:0046597)4.18742750
24lateral sprouting from an epithelium (GO:0060601)4.10104898
25dendritic spine organization (GO:0097061)4.09835000
26negative regulation of chondrocyte differentiation (GO:0032331)4.06559140
27negative regulation of erythrocyte differentiation (GO:0045647)4.05018409
28translational elongation (GO:0006414)4.01069078
29SRP-dependent cotranslational protein targeting to membrane (GO:0006614)4.00707084
30protein retention in ER lumen (GO:0006621)4.00702496
31planar cell polarity pathway involved in neural tube closure (GO:0090179)3.98953632
32ribosomal small subunit biogenesis (GO:0042274)3.98131738
33regulation of heart morphogenesis (GO:2000826)3.94145467
34protein targeting to ER (GO:0045047)3.94006657
35cotranslational protein targeting to membrane (GO:0006613)3.93764342
36cellular protein complex disassembly (GO:0043624)3.86245507
37nuclear-transcribed mRNA catabolic process, nonsense-mediated decay (GO:0000184)3.85496252
38positive regulation of receptor biosynthetic process (GO:0010870)3.84704437
39cellular response to vitamin D (GO:0071305)3.81293045
40Golgi transport vesicle coating (GO:0048200)3.81123728
41COPI coating of Golgi vesicle (GO:0048205)3.81123728
42mesenchymal to epithelial transition involved in metanephros morphogenesis (GO:0003337)3.80153939
43establishment of protein localization to endoplasmic reticulum (GO:0072599)3.77842657
44facial nerve structural organization (GO:0021612)3.76920652
45anatomical structure arrangement (GO:0048532)3.76494426
46pyrimidine deoxyribonucleotide catabolic process (GO:0009223)3.73315898
47morphogenesis of an epithelial fold (GO:0060571)3.72653087
48viral life cycle (GO:0019058)3.71816657
49lung-associated mesenchyme development (GO:0060484)3.71381571
50regulation of establishment of planar polarity involved in neural tube closure (GO:0090178)3.71066457
51regulation of apoptotic process involved in morphogenesis (GO:1902337)3.67629228
52maintenance of protein localization in endoplasmic reticulum (GO:0035437)3.67609790
53negative regulation of T cell mediated immunity (GO:0002710)3.66352295
54proximal/distal pattern formation (GO:0009954)3.62344816
55histone arginine methylation (GO:0034969)3.62185888
56protein localization to endoplasmic reticulum (GO:0070972)3.60414086
57lipopolysaccharide biosynthetic process (GO:0009103)3.57114672
58* middle ear morphogenesis (GO:0042474)3.57046359
59negative regulation of cartilage development (GO:0061037)3.55008438
60maturation of SSU-rRNA (GO:0030490)3.47485518
61pyrimidine nucleotide catabolic process (GO:0006244)3.46333682
62cochlea morphogenesis (GO:0090103)3.45579340
63protein complex disassembly (GO:0043241)3.44548977
64negative regulation of cell fate commitment (GO:0010454)3.44007817
65translational initiation (GO:0006413)3.41428772
66desmosome organization (GO:0002934)3.39136107
67cellular response to vitamin (GO:0071295)3.39074925
68regulation of interleukin-13 production (GO:0032656)3.35432890
69regulation of cellular senescence (GO:2000772)3.31012982
70mammary gland epithelial cell differentiation (GO:0060644)3.29562494
71mesodermal cell differentiation (GO:0048333)3.29456901
72cell proliferation involved in metanephros development (GO:0072203)3.29142213
73pyrimidine deoxyribonucleotide metabolic process (GO:0009219)3.28433217
74epithelial tube branching involved in lung morphogenesis (GO:0060441)3.27872174
75negative regulation of catenin import into nucleus (GO:0035414)3.27727584
76thyroid gland development (GO:0030878)3.26649423
77regulation of Arp2/3 complex-mediated actin nucleation (GO:0034315)3.25722503
78membrane protein intracellular domain proteolysis (GO:0031293)3.24277588
79dendritic spine morphogenesis (GO:0060997)3.23016142
80nephron tubule formation (GO:0072079)3.20896583
81peptide cross-linking (GO:0018149)3.19741563
82definitive hemopoiesis (GO:0060216)3.19717113
83epithelial to mesenchymal transition (GO:0001837)3.19365570
84macromolecular complex disassembly (GO:0032984)3.18477210
85histone H2B ubiquitination (GO:0033523)3.13951241
86keratinocyte proliferation (GO:0043616)3.11413256
87pattern specification involved in kidney development (GO:0061004)3.10093569
88regulation of cell aging (GO:0090342)3.09514805
89lipopolysaccharide metabolic process (GO:0008653)3.09356696
90positive regulation of hair follicle development (GO:0051798)3.09349077
91positive regulation of hair cycle (GO:0042635)3.09349077
92embryonic skeletal system morphogenesis (GO:0048704)3.08075069
93regulation of mammary gland epithelial cell proliferation (GO:0033599)3.06341191
94Wnt signaling pathway, planar cell polarity pathway (GO:0060071)3.03908351
95cell-substrate junction assembly (GO:0007044)3.03278547
96kidney mesenchyme development (GO:0072074)3.02872065
97regulation of cardioblast differentiation (GO:0051890)3.02793255
98protein heterotrimerization (GO:0070208)3.01496454
99negative regulation of cytokine production involved in immune response (GO:0002719)3.00739019
100positive regulation of mesenchymal cell proliferation (GO:0002053)3.00702597
101neural crest cell development (GO:0014032)2.99114378
102embryonic cranial skeleton morphogenesis (GO:0048701)2.98951402
103cranial nerve morphogenesis (GO:0021602)2.98855517
104organ formation (GO:0048645)2.97408535
105negative regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051436)2.97200891
106cardiac epithelial to mesenchymal transition (GO:0060317)2.97169642
107peptidyl-arginine modification (GO:0018195)2.96348862
108acrosome reaction (GO:0007340)2.95150468
109dermatan sulfate biosynthetic process (GO:0030208)2.95008667
110Notch receptor processing (GO:0007220)2.94622576
111regulation of keratinocyte proliferation (GO:0010837)2.94537659
112regulation of branching involved in salivary gland morphogenesis (GO:0060693)2.93890764
113respiratory chain complex IV assembly (GO:0008535)2.93590393
114regulation of viral entry into host cell (GO:0046596)2.93028031
115growth hormone secretion (GO:0030252)2.92965898
116protein targeting to membrane (GO:0006612)2.91929549
117amyloid precursor protein catabolic process (GO:0042987)2.91483248
118lens fiber cell development (GO:0070307)2.91343421
119regulation of establishment of planar polarity (GO:0090175)2.91065953
120negative regulation of DNA repair (GO:0045738)2.91052417
121embryonic skeletal joint morphogenesis (GO:0060272)2.90835227
122cell migration involved in heart development (GO:0060973)2.90356020
123proteasome assembly (GO:0043248)2.88623634
124regulation of mitotic spindle organization (GO:0060236)2.87966692
125lymph vessel development (GO:0001945)2.87910175
126metanephric mesenchyme development (GO:0072075)2.86367184
127collagen fibril organization (GO:0030199)2.86132460
128retrograde vesicle-mediated transport, Golgi to ER (GO:0006890)2.85481218
129axon extension involved in axon guidance (GO:0048846)2.85135060
130neuron projection extension involved in neuron projection guidance (GO:1902284)2.85135060
131non-canonical Wnt signaling pathway (GO:0035567)2.83406975
132positive regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051437)2.83220447
133regulation of mesenchymal cell proliferation (GO:0010464)2.80832659
134mesenchymal to epithelial transition (GO:0060231)2.80499180
135endodermal cell differentiation (GO:0035987)2.80493838
136deoxyribonucleoside monophosphate metabolic process (GO:0009162)2.78865033
137anaphase-promoting complex-dependent proteasomal ubiquitin-dependent protein catabolic process (GO:02.72929232
138negative regulation of ubiquitin-protein transferase activity (GO:0051444)2.72628593
139negative regulation of ligase activity (GO:0051352)2.72628593
140retinal ganglion cell axon guidance (GO:0031290)2.70736377
141central nervous system projection neuron axonogenesis (GO:0021952)2.70484066
142membrane protein ectodomain proteolysis (GO:0006509)2.69867311
143regulation of nephron tubule epithelial cell differentiation (GO:0072182)2.69107412
144cytochrome complex assembly (GO:0017004)2.69105425
145base-excision repair, AP site formation (GO:0006285)2.68225669
146response to interferon-alpha (GO:0035455)2.66693711
147intracellular estrogen receptor signaling pathway (GO:0030520)2.66691446
148DNA unwinding involved in DNA replication (GO:0006268)2.65721238
149organ induction (GO:0001759)2.64525365
150DNA strand elongation (GO:0022616)2.64484366
151glucocorticoid receptor signaling pathway (GO:0042921)2.64383027
152skeletal system morphogenesis (GO:0048705)2.63954662
153regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051439)2.62863463
154regulation of spindle organization (GO:0090224)2.62631883
155epithelial cell differentiation involved in prostate gland development (GO:0060742)2.62566354
156regulation of cellular amino acid metabolic process (GO:0006521)2.62556495
157regulation of vitamin D biosynthetic process (GO:0060556)2.59348040
158blastocyst development (GO:0001824)2.56959665
159formation of translation preinitiation complex (GO:0001731)2.56284243
160DNA strand elongation involved in DNA replication (GO:0006271)2.54023287
161mitotic nuclear envelope reassembly (GO:0007084)2.50367412
162nuclear envelope reassembly (GO:0031468)2.50367412
163* anterior/posterior pattern specification (GO:0009952)2.50188219
164regulation of transmission of nerve impulse (GO:0051969)2.46979499
165heparan sulfate proteoglycan biosynthetic process (GO:0015012)2.46726204
166establishment of tissue polarity (GO:0007164)2.45872285
167establishment of planar polarity (GO:0001736)2.45872285
168negative regulation of axon extension involved in axon guidance (GO:0048843)2.45624319
169negative regulation of smooth muscle cell migration (GO:0014912)2.44203413
170negative regulation of axon guidance (GO:1902668)2.43527885
171spinal cord association neuron differentiation (GO:0021527)2.43037193
172protein deneddylation (GO:0000338)2.42623590
173beta-amyloid metabolic process (GO:0050435)2.39833284
174pyrimidine-containing compound salvage (GO:0008655)2.38744147
175pyrimidine nucleoside salvage (GO:0043097)2.38744147
176regulation of telomerase activity (GO:0051972)2.37075146
177embryonic organ morphogenesis (GO:0048562)2.36969071
178response to UV-B (GO:0010224)2.36899202
179hippo signaling (GO:0035329)2.36633429
180neurogenesis (GO:0022008)2.36205062
181face development (GO:0060324)2.35541646

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1TP63_17297297_ChIP-ChIP_HaCaT_Human7.39455808
2RBPJ_22232070_ChIP-Seq_NCS_Mouse5.63850983
3HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse4.88861976
4MYBL1_21750041_ChIP-ChIP_SPERMATOCYTES_Mouse3.99198523
5CHD7_19251738_ChIP-ChIP_MESCs_Mouse3.63212262
6HCFC1_20581084_ChIP-Seq_MESCs_Mouse3.22741484
7JARID1A_20064375_ChIP-Seq_MESCs_Mouse3.17733220
8TRP63_18441228_ChIP-ChIP_KERATINOCYTES_Mouse3.07119885
9RARG_19884340_ChIP-ChIP_MEFs_Mouse2.96573313
10NOTCH1_17114293_ChIP-ChIP_T-ALL_Human2.92841823
11STAT6_21828071_ChIP-Seq_BEAS2B_Human2.84369788
12CREB1_15753290_ChIP-ChIP_HEK293T_Human2.81689265
13AR_21909140_ChIP-Seq_LNCAP_Human2.61746707
14* PPARG_19300518_ChIP-PET_3T3-L1_Mouse2.56688428
15PPARG_23326641_ChIP-Seq_C3H10T1-2_Mouse2.55629434
16* PRDM5_23873026_ChIP-Seq_MEFs_Mouse2.48783952
17E2F7_22180533_ChIP-Seq_HELA_Human2.48631498
18THAP11_20581084_ChIP-Seq_MESCs_Mouse2.47812076
19KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human2.47566494
20* WT1_20215353_ChIP-ChIP_NEPHRON_PROGENITOR_Mouse2.44256782
21GABP_17652178_ChIP-ChIP_JURKAT_Human2.43696447
22SMAD4_19686287_ChIP-ChIP_HaCaT_Human2.42318230
23CIITA_25753668_ChIP-Seq_RAJI_Human2.41999838
24NUCKS1_24931609_ChIP-Seq_HEPATOCYTES_Mouse2.31552312
25CLOCK_20551151_ChIP-Seq_293T_Human2.31441777
26FOXM1_23109430_ChIP-Seq_U2OS_Human2.28408243
27GABP_19822575_ChIP-Seq_HepG2_Human2.28349177
28MYC_18555785_ChIP-Seq_MESCs_Mouse2.25308757
29ETS1_20019798_ChIP-Seq_JURKAT_Human2.24074612
30* KLF4_19030024_ChIP-ChIP_MESCs_Mouse2.17814890
31* SOX9_24532713_ChIP-Seq_HFSC_Mouse2.15077069
32TP63_19390658_ChIP-ChIP_HaCaT_Human2.11351413
33SCL_19346495_ChIP-Seq_HPC-7_Human2.09031423
34MYC_18358816_ChIP-ChIP_MESCs_Mouse2.08404640
35WT1_19549856_ChIP-ChIP_CCG9911_Human2.05521015
36* TP53_20018659_ChIP-ChIP_R1E_Mouse2.03729338
37ELF1_17652178_ChIP-ChIP_JURKAT_Human2.03548000
38ELK3_25401928_ChIP-Seq_HUVEC_Human2.02185088
39DMRT1_21621532_ChIP-ChIP_FETAL_Ovary2.00859063
40* PHC1_16625203_ChIP-ChIP_MESCs_Mouse2.00133671
41CIITA_18437201_ChIP-ChIP_Raji_B_and_iDC_Human1.98792826
42ZNF652_21678463_ChIP-ChIP_ZR75-1_Human1.91048620
43RUNX2_24764292_ChIP-Seq_MC3T3_Mouse1.90080228
44TRIM28_21343339_ChIP-Seq_HEK293_Human1.89593556
45EP300_20729851_ChIP-Seq_FORBRAIN_MIDBRAIN_LIMB_HEART_Mouse1.88542552
46* ZFP42_18358816_ChIP-ChIP_MESCs_Mouse1.86705460
47CREB1_23762244_ChIP-Seq_HIPPOCAMPUS_Rat1.86508797
48* CEBPD_21427703_ChIP-Seq_3T3-L1_Mouse1.85462056
49YY1_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse1.85053871
50ZFP281_18358816_ChIP-ChIP_MESCs_Mouse1.82804698
51ESR1_21235772_ChIP-Seq_MCF-7_Human1.82183169
52POU5F1_16153702_ChIP-ChIP_HESCs_Human1.81667706
53MYC_19030024_ChIP-ChIP_MESCs_Mouse1.76052625
54DCP1A_22483619_ChIP-Seq_HELA_Human1.75754079
55HOXD13_18407260_ChIP-ChIP_DEVELOPING-LIMBS_Mouse1.73366654
56ESR1_15608294_ChIP-ChIP_MCF-7_Human1.72542516
57HIF1A_21447827_ChIP-Seq_MCF-7_Human1.72432735
58* UBF1/2_26484160_Chip-Seq_HMECs_Human1.72372719
59MYCN_18555785_ChIP-Seq_MESCs_Mouse1.69853477
60IRF1_19129219_ChIP-ChIP_H3396_Human1.69231996
61E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse1.66680913
62ELK1_22589737_ChIP-Seq_MCF10A_Human1.65728317
63E2F1_18555785_ChIP-Seq_MESCs_Mouse1.65272354
64PPARD_23176727_ChIP-Seq_KERATINOCYTES_Mouse1.62262888
65* EED_16625203_ChIP-ChIP_MESCs_Mouse1.62101239
66ETS2_20176728_ChIP-ChIP_TROPHOBLAST_STEM_CELLS_Mouse1.61301259
67MYC_19079543_ChIP-ChIP_MESCs_Mouse1.61130066
68TCF21_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human1.59254549
69ZFP281_18757296_ChIP-ChIP_E14_Mouse1.59060160
70* RNF2_16625203_ChIP-ChIP_MESCs_Mouse1.57683645
71* CEBPB_24764292_ChIP-Seq_MC3T3_Mouse1.53648856
72CDKN2AIP_20523734_ChIP-Seq_CORTICAL_Neurons1.52297317
73TP53_22127205_ChIP-Seq_IMR90_Human1.51828199
74* SMAD2_18955504_ChIP-ChIP_HaCaT_Human1.49199091
75* SMAD3_18955504_ChIP-ChIP_HaCaT_Human1.49199091
76DACH1_20351289_ChIP-Seq_MDA-MB-231_Human1.48896953
77KDM5A_27292631_Chip-Seq_BREAST_Human1.48369415
78CTNNB1_20615089_ChIP-ChIP_FETAL_BRAIN_Human1.44298152
79* KDM5B_21448134_ChIP-Seq_MESCs_Mouse1.42796619
80* TRIM28_19339689_ChIP-ChIP_MESCs_Mouse1.39910599
81EKLF_21900194_ChIP-Seq_ERYTHROCYTE_Mouse1.39213158
82BRD4_25478319_ChIP-Seq_HGPS_Human1.37910135
83SALL1_21062744_ChIP-ChIP_HESCs_Human1.36978993
84TCF3_18692474_ChIP-Seq_MEFs_Mouse1.36244297
85CTCF_18555785_ChIP-Seq_MESCs_Mouse1.36160829
86KDM2B_26808549_Chip-Seq_JURKAT_Human1.36044624
87CREM_20920259_ChIP-Seq_GC1-SPG_Mouse1.34755347
88XRN2_22483619_ChIP-Seq_HELA_Human1.33749274
89FOXO3_22982991_ChIP-Seq_MACROPHAGES_Mouse1.32189019
90NFIB_24661679_ChIP-Seq_LUNG_Mouse1.31838020
91* CEBPB_21427703_ChIP-Seq_3T3-L1_Mouse1.31799973
92TTF2_22483619_ChIP-Seq_HELA_Human1.31727816
93FOXP3_21729870_ChIP-Seq_TREG_Human1.31491385
94E2F1_21310950_ChIP-Seq_MCF-7_Human1.29363125
95TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat1.29200835
96KLF4_26769127_Chip-Seq_PDAC-Cell_line_Human1.28617563
97CREB1_20920259_ChIP-Seq_GC1-SPG_Mouse1.27672896
98P300_27058665_Chip-Seq_ZR-75-30cells_Human1.26803427
99KLF6_26769127_Chip-Seq_PDAC-Cell_line_Human1.26700352
100ESR1_22446102_ChIP-Seq_UTERUS_Mouse1.22088932
101MYC_22102868_ChIP-Seq_BL_Human1.22000332
102EP300_21415370_ChIP-Seq_HL-1_Mouse1.21766761
103ELF3_26769127_Chip-Seq_PDAC-Cell_line_Human1.20950363
104KDM2B_26808549_Chip-Seq_SIL-ALL_Human1.20067992
105UBF1/2_26484160_Chip-Seq_HMEC-DERIVED_Human1.18628675
106HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human1.18310388
107ZFP281_27345836_Chip-Seq_ESCs_Mouse1.16696879
108POU5F1_18555785_ChIP-Seq_MESCs_Mouse1.16659217
109ESR2_21235772_ChIP-Seq_MCF-7_Human1.14493541
110SREBP1_19666523_ChIP-Seq_LIVER_Mouse1.14243858
111NANOG_16153702_ChIP-ChIP_HESCs_Human1.13904909
112E2F4_17652178_ChIP-ChIP_JURKAT_Human1.12747864
113ZFP322A_24550733_ChIP-Seq_MESCs_Mouse1.11439454
114PKCTHETA_26484144_Chip-Seq_BREAST_Human1.09188743
115SOX2_18358816_ChIP-ChIP_MESCs_Mouse1.09001492
116EST1_17652178_ChIP-ChIP_JURKAT_Human1.08568705
117FOXM1_26100407_CHIP-SEQ_Hek293_flp-in_Human1.07654586
118FOXM1_25889361_ChIP-Seq_OE33_AND_U2OS_Human1.07611572
119* RING1B_27294783_Chip-Seq_NPCs_Mouse1.06495586
120POU5F1_18358816_ChIP-ChIP_MESCs_Mouse1.06391612
121SOX2_16153702_ChIP-ChIP_HESCs_Human1.06386049
122KDM2B_26808549_Chip-Seq_SUP-B15_Human1.06244251
123* CBX2_27304074_Chip-Seq_ESCs_Mouse1.05186238
124PADI4_21655091_ChIP-ChIP_MCF-7_Human1.05119493
125BCL3_23251550_ChIP-Seq_MUSCLE_Mouse1.04898649
126TCF3_18467660_ChIP-ChIP_MESCs_Mouse1.04455320
127SMARCA4_20176728_ChIP-ChIP_TSCs_Mouse1.02891220
128DMRT1_23473982_ChIP-Seq_TESTES_Mouse1.02888041
129NKX2-5_21415370_ChIP-Seq_HL-1_Mouse1.02652978
130* SUZ12_16625203_ChIP-ChIP_MESCs_Mouse1.02113547
131CEBPD_23245923_ChIP-Seq_MEFs_Mouse1.01890177
132* CCND1_20090754_ChIP-ChIP_RETINA_Mouse1.00759650
133SALL4_18804426_ChIP-ChIP_XEN_Mouse1.00190525
134* EZH2_18974828_ChIP-Seq_MESCs_Mouse0.99453001
135* RNF2_18974828_ChIP-Seq_MESCs_Mouse0.99453001
136TET1_21451524_ChIP-Seq_MESCs_Mouse0.99259921
137ISL1_27105846_Chip-Seq_CPCs_Mouse0.98826310
138RACK7_27058665_Chip-Seq_MCF-7_Human0.98173314
139TCF4_18268006_ChIP-ChIP_LS174T_Human0.98044633
140* TBP_23326641_ChIP-Seq_C3H10T1-2_Mouse0.97460947
141ATF3_23680149_ChIP-Seq_GBM1-GSC_Human0.96872080
142GATA4_21415370_ChIP-Seq_HL-1_Mouse0.96767962
143P63_26484246_Chip-Seq_KERATINOCYTES_Human0.96179319
144IKZF1_21737484_ChIP-ChIP_HCT116_Human0.95996790
145E2F4_21247883_ChIP-Seq_LYMPHOBLASTOID_Human0.95808853
146TCF7_22412390_ChIP-Seq_EML_Mouse0.95669716
147GLI1_17442700_ChIP-ChIP_MESCs_Mouse0.95403447
148PAX6_23342162_ChIP-ChIP_BETA-FORBRAIN-LENS_Mouse0.95312048
149ERG_21242973_ChIP-ChIP_JURKAT_Human0.95234537
150NELFA_20434984_ChIP-Seq_ESCs_Mouse0.94426897
151SA1_22415368_ChIP-Seq_MEFs_Mouse0.93862609
152HOXB4_20404135_ChIP-ChIP_EML_Mouse0.93786639
153* TCFAP2C_20176728_ChIP-ChIP_TROPHOBLAST_STEM_CELLS_Mouse0.92945841
154ZFX_18555785_ChIP-Seq_MESCs_Mouse0.92748731
155ATF3_27146783_Chip-Seq_COLON_Human0.92733548
156* SOX2_20726797_ChIP-Seq_SW620_Human0.92726387
157HSF1_23293686_ChIP-Seq_STHDH_STRIATAL_Mouse0.92284768
158KDM2B_26808549_Chip-Seq_DND41_Human0.91995355
159CNOT3_19339689_ChIP-ChIP_MESCs_Mouse0.91542879
160EOMES_20176728_ChIP-ChIP_TSCs_Mouse0.91523568
161MYC_18940864_ChIP-ChIP_HL60_Human0.91290082
162SMC1_22415368_ChIP-Seq_MEFs_Mouse0.90226453
163FOXP1_21924763_ChIP-Seq_HESCs_Human0.89845100
164* RING1B_27294783_Chip-Seq_ESCs_Mouse0.89363921
165CHD1_26751641_Chip-Seq_LNCaP_Human0.88367805

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0010030_abnormal_orbit_morphology4.27153676
2MP0003705_abnormal_hypodermis_morpholog3.54086179
3MP0008438_abnormal_cutaneous_collagen3.42630094
4MP0002282_abnormal_trachea_morphology3.30449004
5MP0002249_abnormal_larynx_morphology3.09709473
6MP0005623_abnormal_meninges_morphology2.95575506
7MP0010368_abnormal_lymphatic_system2.89167422
8MP0009250_abnormal_appendicular_skeleto2.71428840
9MP0009379_abnormal_foot_pigmentation2.67967917
10MP0000537_abnormal_urethra_morphology2.48546129
11MP0005503_abnormal_tendon_morphology2.44428747
12MP0002938_white_spotting2.37088285
13MP0005275_abnormal_skin_tensile2.36582879
14MP0005499_abnormal_olfactory_system2.35995484
15MP0005394_taste/olfaction_phenotype2.35995484
16MP0002653_abnormal_ependyma_morphology2.35298178
17* MP0000049_abnormal_middle_ear2.27126037
18MP0009053_abnormal_anal_canal2.26952790
19MP0003385_abnormal_body_wall2.12819291
20MP0004272_abnormal_basement_membrane2.04706433
21* MP0005508_abnormal_skeleton_morphology1.96741065
22MP0002932_abnormal_joint_morphology1.96338953
23MP0001727_abnormal_embryo_implantation1.94029023
24MP0003942_abnormal_urinary_system1.92995726
25MP0001849_ear_inflammation1.91774727
26MP0003111_abnormal_nucleus_morphology1.90288475
27MP0003937_abnormal_limbs/digits/tail_de1.89175445
28MP0002822_catalepsy1.87811205
29MP0001879_abnormal_lymphatic_vessel1.84215790
30MP0001661_extended_life_span1.81775282
31MP0001299_abnormal_eye_distance/1.81561881
32MP0009384_cardiac_valve_regurgitation1.78407844
33MP0005171_absent_coat_pigmentation1.77625794
34MP0000678_abnormal_parathyroid_gland1.76228096
35MP0003566_abnormal_cell_adhesion1.71227356
36MP0003279_aneurysm1.68071903
37MP0010094_abnormal_chromosome_stability1.66784324
38MP0002060_abnormal_skin_morphology1.63656406
39MP0003077_abnormal_cell_cycle1.58963128
40MP0008057_abnormal_DNA_replication1.58473477
41MP0006054_spinal_hemorrhage1.52212309
42MP0008058_abnormal_DNA_repair1.51712940
43MP0000534_abnormal_ureter_morphology1.48248383
44* MP0003755_abnormal_palate_morphology1.47971172
45MP0003283_abnormal_digestive_organ1.46696375
46MP0004197_abnormal_fetal_growth/weight/1.45858048
47MP0003123_paternal_imprinting1.45799963
48MP0003011_delayed_dark_adaptation1.45615359
49* MP0000762_abnormal_tongue_morphology1.43808165
50* MP0000428_abnormal_craniofacial_morphol1.43324844
51MP0004858_abnormal_nervous_system1.42548579
52* MP0000163_abnormal_cartilage_morphology1.40249113
53* MP0002177_abnormal_outer_ear1.39522588
54* MP0003935_abnormal_craniofacial_develop1.39306596
55MP0000733_abnormal_muscle_development1.37676770
56MP0002233_abnormal_nose_morphology1.37652555
57MP0002877_abnormal_melanocyte_morpholog1.37076564
58MP0005257_abnormal_intraocular_pressure1.34984726
59MP0003828_pulmonary_edema1.34646547
60MP0003938_abnormal_ear_development1.34199081
61MP0001730_embryonic_growth_arrest1.30521890
62MP0004133_heterotaxia1.29420544
63MP0002116_abnormal_craniofacial_bone1.28467071
64MP0008007_abnormal_cellular_replicative1.28367640
65MP0000432_abnormal_head_morphology1.28348495
66MP0002396_abnormal_hematopoietic_system1.26455921
67MP0003878_abnormal_ear_physiology1.25675392
68MP0005377_hearing/vestibular/ear_phenot1.25675392
69MP0002132_abnormal_respiratory_system1.25034639
70MP0002108_abnormal_muscle_morphology1.24079679
71MP0001340_abnormal_eyelid_morphology1.23537352
72MP0002896_abnormal_bone_mineralization1.23153162
73MP0002111_abnormal_tail_morphology1.22120460
74MP0003115_abnormal_respiratory_system1.20758099
75MP0000465_gastrointestinal_hemorrhage1.20485078
76MP0002114_abnormal_axial_skeleton1.20052423
77MP0002109_abnormal_limb_morphology1.18636662
78MP0002115_abnormal_skeleton_extremities1.18481846
79MP0004185_abnormal_adipocyte_glucose1.16740299
80MP0000427_abnormal_hair_cycle1.15942173
81MP0003300_gastrointestinal_ulcer1.15051328
82MP0001958_emphysema1.13141555
83MP0005023_abnormal_wound_healing1.12879219
84MP0005666_abnormal_adipose_tissue1.12528025
85MP0008260_abnormal_autophagy1.11243345
86MP0001529_abnormal_vocalization1.10475398
87MP0001286_abnormal_eye_development1.09772210
88MP0000778_abnormal_nervous_system1.09680148
89MP0005248_abnormal_Harderian_gland1.08754830
90MP0003122_maternal_imprinting1.08746488
91MP0005409_darkened_coat_color1.08280187
92MP0003252_abnormal_bile_duct1.06958978
93MP0003119_abnormal_digestive_system1.06401101
94MP0001346_abnormal_lacrimal_gland1.05967548
95MP0000377_abnormal_hair_follicle1.05774772
96MP0000462_abnormal_digestive_system1.05628386
97MP0001348_abnormal_lacrimal_gland1.05558771
98MP0008789_abnormal_olfactory_epithelium1.02851981
99MP0002234_abnormal_pharynx_morphology1.02783933
100MP0003950_abnormal_plasma_membrane1.02581225
101MP0002113_abnormal_skeleton_development1.02349386
102MP0000955_abnormal_spinal_cord0.99123517
103MP0000569_abnormal_digit_pigmentation0.98332044
104MP0003567_abnormal_fetal_cardiomyocyte0.98072416
105MP0002269_muscular_atrophy0.97728833
106MP0003718_maternal_effect0.97715441
107MP0002092_abnormal_eye_morphology0.96730748
108MP0008932_abnormal_embryonic_tissue0.96147764
109MP0010234_abnormal_vibrissa_follicle0.95042740
110MP0003315_abnormal_perineum_morphology0.94060371
111MP0004233_abnormal_muscle_weight0.92393025
112MP0006138_congestive_heart_failure0.91973273
113MP0000383_abnormal_hair_follicle0.91842947
114MP0004134_abnormal_chest_morphology0.91543590
115MP0001293_anophthalmia0.90993234
116MP0002127_abnormal_cardiovascular_syste0.89139529
117MP0002925_abnormal_cardiovascular_devel0.88895033
118MP0000516_abnormal_urinary_system0.88778479
119MP0005367_renal/urinary_system_phenotyp0.88778479
120MP0002098_abnormal_vibrissa_morphology0.88209097
121MP0002084_abnormal_developmental_patter0.88190080
122MP0002184_abnormal_innervation0.87533167
123* MP0003861_abnormal_nervous_system0.86853475
124MP0002928_abnormal_bile_duct0.86422286
125MP0005380_embryogenesis_phenotype0.86231802
126MP0001672_abnormal_embryogenesis/_devel0.86231802
127MP0002089_abnormal_postnatal_growth/wei0.86179846
128MP0000013_abnormal_adipose_tissue0.85223828
129MP0000350_abnormal_cell_proliferation0.85003052
130MP0005391_vision/eye_phenotype0.83897307
131MP0000759_abnormal_skeletal_muscle0.83756874
132MP0000003_abnormal_adipose_tissue0.83598535
133MP0005501_abnormal_skin_physiology0.83182821
134* MP0005390_skeleton_phenotype0.83181048
135MP0010352_gastrointestinal_tract_polyps0.82553203
136MP0005193_abnormal_anterior_eye0.80615438
137MP0002697_abnormal_eye_size0.79767024
138MP0005187_abnormal_penis_morphology0.78355228
139MP0003091_abnormal_cell_migration0.78172111
140MP0000467_abnormal_esophagus_morphology0.77744459
141MP0001177_atelectasis0.77171246
142MP0004808_abnormal_hematopoietic_stem0.76507327
143* MP0002085_abnormal_embryonic_tissue0.73998807
144MP0000767_abnormal_smooth_muscle0.73698628
145MP0009931_abnormal_skin_appearance0.72935938
146MP0000681_abnormal_thyroid_gland0.72236180
147MP0001216_abnormal_epidermal_layer0.72074409
148MP0002128_abnormal_blood_circulation0.72036871
149MP0001243_abnormal_dermal_layer0.71881722
150MP0005076_abnormal_cell_differentiation0.70525045
151MP0004957_abnormal_blastocyst_morpholog0.69918695

Predicted human phenotypes

RankGene SetZ-score
1Protrusio acetabuli (HP:0003179)4.91951385
2Fragile nails (HP:0001808)4.62821834
3Premature rupture of membranes (HP:0001788)4.29807174
4Microvesicular hepatic steatosis (HP:0001414)4.17885510
5Facial cleft (HP:0002006)4.16817000
6Atrophic scars (HP:0001075)4.15301530
7Down-sloping shoulders (HP:0200021)4.13449404
8Shallow orbits (HP:0000586)3.79655443
9Thin bony cortex (HP:0002753)3.59339241
10Neonatal short-limb short stature (HP:0008921)3.43082645
11Short 4th metacarpal (HP:0010044)3.26878433
12Aplasia/Hypoplasia of the 4th metacarpal (HP:0010042)3.26878433
13Bell-shaped thorax (HP:0001591)3.23550619
14Ankle contracture (HP:0006466)3.14315678
15Hyperacusis (HP:0010780)3.10875423
16Coronal craniosynostosis (HP:0004440)3.01223417
17Fragile skin (HP:0001030)2.98676939
18Trismus (HP:0000211)2.92630518
19Elevated circulating parathyroid hormone (PTH) level (HP:0003165)2.86110302
20Milia (HP:0001056)2.80575918
21Abnormal isoelectric focusing of serum transferrin (HP:0003160)2.78705699
22Abnormal protein N-linked glycosylation (HP:0012347)2.78705699
23Abnormal protein glycosylation (HP:0012346)2.78705699
24Abnormal glycosylation (HP:0012345)2.78705699
25Syringomyelia (HP:0003396)2.78660471
26Spinal cord lesions (HP:0100561)2.78660471
27Degeneration of anterior horn cells (HP:0002398)2.76630746
28Abnormality of the anterior horn cell (HP:0006802)2.76630746
29Trigonocephaly (HP:0000243)2.75437142
30Soft skin (HP:0000977)2.69708014
31Abnormality of the 4th metacarpal (HP:0010012)2.67792747
32Insomnia (HP:0100785)2.66405458
33Natal tooth (HP:0000695)2.65452153
34Nonimmune hydrops fetalis (HP:0001790)2.64623558
35Median cleft lip (HP:0000161)2.62683897
36Abnormal number of incisors (HP:0011064)2.61006121
37Cerebral hypomyelination (HP:0006808)2.57769346
38Type I transferrin isoform profile (HP:0003642)2.57695639
39Mitral regurgitation (HP:0001653)2.53561163
40Tibial bowing (HP:0002982)2.52827505
41Midline defect of the nose (HP:0004122)2.51436341
42Abnormality of dentin (HP:0010299)2.51229605
43Distal lower limb muscle weakness (HP:0009053)2.50077747
44Renal duplication (HP:0000075)2.42979099
45Camptodactyly of toe (HP:0001836)2.42519476
46Spinal cord compression (HP:0002176)2.40815731
47Abnormality of the 2nd finger (HP:0004100)2.37911219
4811 pairs of ribs (HP:0000878)2.37604743
49Alacrima (HP:0000522)2.37280728
50Broad metatarsal (HP:0001783)2.34102211
51Myelomeningocele (HP:0002475)2.32193071
52Selective tooth agenesis (HP:0001592)2.31764605
53Peritonitis (HP:0002586)2.26434467
54Lymphangioma (HP:0100764)2.23195791
55Short nail (HP:0001799)2.22606348
56Hypokinesia (HP:0002375)2.21888209
57Ectopic anus (HP:0004397)2.20122944
58Dilatation of the ascending aorta (HP:0005111)2.19638647
59Abnormality of the distal phalanges of the toes (HP:0010182)2.19358859
60Abnormality of the parathyroid morphology (HP:0011766)2.18930425
61Microretrognathia (HP:0000308)2.18904693
62Aortic aneurysm (HP:0004942)2.16592746
63Abnormality of the lower motor neuron (HP:0002366)2.15817641
64Spinal rigidity (HP:0003306)2.15350222
65Scapular winging (HP:0003691)2.14446017
66Arnold-Chiari malformation (HP:0002308)2.14411809
67High anterior hairline (HP:0009890)2.14239088
68Reticulocytopenia (HP:0001896)2.12199268
69Missing ribs (HP:0000921)2.11962448
70Aplasia/Hypoplasia of the sacrum (HP:0008517)2.11934667
71Elbow flexion contracture (HP:0002987)2.11105446
72Rectovaginal fistula (HP:0000143)2.10447468
73Rectal fistula (HP:0100590)2.10447468
74Bifid uvula (HP:0000193)2.10147711
75Buphthalmos (HP:0000557)2.09999142
76Distal upper limb amyotrophy (HP:0007149)2.09743309
77Upper limb amyotrophy (HP:0009129)2.09743309
78Bladder diverticulum (HP:0000015)2.08239087
79Mesangial abnormality (HP:0001966)2.08065602
80Advanced eruption of teeth (HP:0006288)2.07947455
81Onycholysis (HP:0001806)2.07479545
82Limb-girdle muscle atrophy (HP:0003797)2.06449878
83Ileus (HP:0002595)2.05535808
84Septate vagina (HP:0001153)2.05246337
85Delayed cranial suture closure (HP:0000270)2.03541122
86Macroorchidism (HP:0000053)2.03120818
87Abnormal auditory evoked potentials (HP:0006958)2.02971278
88Morphological abnormality of the middle ear (HP:0008609)2.02895290
89Acute lymphatic leukemia (HP:0006721)2.02809314
90Abnormality of the nasal septum (HP:0000419)2.01816326
91Short palpebral fissure (HP:0012745)2.01246210
92Esophageal atresia (HP:0002032)2.01018100
93Deviation of the hallux (HP:0010051)1.98916975
94Sparse lateral eyebrow (HP:0005338)1.98402038
95Glossoptosis (HP:0000162)1.98334499
96Mitral valve prolapse (HP:0001634)1.97715235
97Vascular tortuosity (HP:0004948)1.97691376
98Hallux valgus (HP:0001822)1.97284341
99Abnormality of the anterior chamber (HP:0000593)1.96912773
100Aplastic anemia (HP:0001915)1.96598069
101Shoulder girdle muscle weakness (HP:0003547)1.96449976
102Bronchomalacia (HP:0002780)1.96051609
103Disproportionate tall stature (HP:0001519)1.94610833
104Polycystic kidney dysplasia (HP:0000113)1.94338314
105Aortic dissection (HP:0002647)1.94138792
106Cervical subluxation (HP:0003308)1.93973323
107Hand muscle atrophy (HP:0009130)1.93810451
108Type 1 muscle fiber predominance (HP:0003803)1.92839768
109Intestinal fistula (HP:0100819)1.92512999
110Adducted thumb (HP:0001181)1.92088733
111Abnormality of the parietal bone (HP:0002696)1.91717013
112Woolly hair (HP:0002224)1.91443334
113Wormian bones (HP:0002645)1.90982086
114Broad toe (HP:0001837)1.90936168
115Increased connective tissue (HP:0009025)1.90252851
116Plantar hyperkeratosis (HP:0007556)1.89744969
117Abnormality of the costochondral junction (HP:0000919)1.89631126
118Broad face (HP:0000283)1.88956611
119Inguinal hernia (HP:0000023)1.88908317
120Pelvic girdle muscle weakness (HP:0003749)1.87984491
121Rimmed vacuoles (HP:0003805)1.87909014
122Smooth philtrum (HP:0000319)1.87706439
123Follicular hyperkeratosis (HP:0007502)1.86989691
124Slender build (HP:0001533)1.86866562
125Anal stenosis (HP:0002025)1.86701260
126Abnormality of the acetabulum (HP:0003170)1.86490524
127Decreased lacrimation (HP:0000633)1.86294068
128Rough bone trabeculation (HP:0100670)1.85984322
129Achilles tendon contracture (HP:0001771)1.84975849
130Subacute progressive viral hepatitis (HP:0006572)1.84352522
131Primitive reflexes (palmomental, snout, glabellar) (HP:0002476)1.84229730
132Asymmetry of the thorax (HP:0001555)1.84028907
133Colon cancer (HP:0003003)1.83267203
134Poikiloderma (HP:0001029)1.82454456
135Wide anterior fontanel (HP:0000260)1.81586143
136Concave nail (HP:0001598)1.81023272
137Joint contractures involving the joints of the feet (HP:0100492)1.81014535
138Flexion contracture of toe (HP:0005830)1.81014535
139Increased density of long bones (HP:0006392)1.80094694
140Germ cell neoplasia (HP:0100728)1.79524411
141Femoral bowing (HP:0002980)1.79320898
142Broad hallux (HP:0010055)1.79199841
143Oligodontia (HP:0000677)1.77381611
144Abnormality of the phalanges of the hallux (HP:0010057)1.77321724
145Blue sclerae (HP:0000592)1.76457372
146Large earlobe (HP:0009748)1.76184102
147Omphalocele (HP:0001539)1.75608792
148Renovascular hypertension (HP:0100817)1.74967946
149Chin dimple (HP:0010751)1.74758027
150Broad thumb (HP:0011304)1.74547058
151Vaginal fistula (HP:0004320)1.74478344
152Ragged-red muscle fibers (HP:0003200)1.74410511
153Esotropia (HP:0000565)1.73960684
154Calcaneovalgus deformity (HP:0001848)1.72684746
155Partial duplication of the phalanx of hand (HP:0009999)1.72571544
156Pointed chin (HP:0000307)1.72563950
157Elfin facies (HP:0004428)1.72272678
158Bifid tongue (HP:0010297)1.72173753
159Protruding ear (HP:0000411)1.71869535
160Neoplasm of the pancreas (HP:0002894)1.71402905
161Proximal placement of thumb (HP:0009623)1.71045897
162Pterygium (HP:0001059)1.70911901
163Atresia of the external auditory canal (HP:0000413)1.70164302
164Abnormality of the Achilles tendon (HP:0005109)1.69837327
165Abnormal ossification of hand bones (HP:0005921)1.69718484
166Deviation of the thumb (HP:0009603)1.69534121
167Abnormal umbilical cord blood vessels (HP:0011403)1.69090220
168Single umbilical artery (HP:0001195)1.69090220
169Abnormality of the fetal cardiovascular system (HP:0010948)1.69090220
170Diastasis recti (HP:0001540)1.68451859
171Mildly elevated creatine phosphokinase (HP:0008180)1.68308023
172Hammertoe (HP:0001765)1.68051696
173Vertebral compression fractures (HP:0002953)1.67535245
174Abnormality of the peritoneum (HP:0002585)1.66907712
175Ridged nail (HP:0001807)1.65614957
176Sprengel anomaly (HP:0000912)1.65223283
177Patchy hypopigmentation of hair (HP:0011365)1.64233544
178Optic nerve coloboma (HP:0000588)1.64053561
179Overriding aorta (HP:0002623)1.63956556
180Preaxial hand polydactyly (HP:0001177)1.63146591
181Abnormality of the hip-girdle musculature (HP:0001445)1.63026926
182Abnormality of the musculature of the pelvis (HP:0001469)1.63026926
183Broad palm (HP:0001169)1.62687334
184Atrophy/Degeneration involving motor neurons (HP:0007373)1.62539413

Predicted kinase interactions (KEA)

RankGene SetZ-score
1EPHB24.98314794
2BRD43.42051918
3MKNK13.35971776
4EEF2K3.14361844
5MST1R2.95380426
6TLK12.93594653
7LATS12.65184868
8ERN12.64942800
9DYRK32.62858497
10ICK2.57847187
11TRIB32.47901888
12SIK12.30111256
13DDR22.16315228
14STK162.15651510
15PKN22.15157107
16TGFBR12.13889014
17PTK62.09925472
18LRRK22.06991394
19BRSK12.04243356
20RPS6KB22.00677553
21TTN1.99508161
22LATS21.97973895
23MKNK21.89730461
24ILK1.89673883
25CDK121.87902971
26CSNK1G21.85143301
27SMG11.78701606
28PBK1.76039618
29CDK91.70982397
30DMPK1.62259832
31MAP3K61.61922207
32ERBB31.58815723
33PDGFRA1.56554668
34TRPM71.54041549
35PAK21.53067667
36BUB11.52317119
37MAP2K71.45581495
38BCR1.43434925
39CDK81.42907142
40TESK21.34834205
41CSNK1A1L1.33928625
42PAK41.31666520
43MAP3K101.26726049
44NME11.25955467
45CDC71.25589243
46LIMK11.22422617
47MAPKAPK31.17771179
48EIF2AK11.15208681
49MAP4K21.14066127
50MAPKAPK51.13709672
51SIK21.12486874
52PASK1.12330695
53EPHB11.10728542
54FER1.07896228
55BTK1.04000828
56CDK191.00871083
57DYRK1B0.99977670
58ATR0.98622555
59CSNK1G30.97845650
60CDK60.97826673
61ABL20.97474374
62ROCK10.97427244
63RPS6KA40.97396613
64TGFBR20.96451116
65MAP2K40.96295216
66NEK20.96249501
67NTRK10.96052291
68CSNK1G10.95439064
69PRKD10.87750718
70CHEK20.86301887
71CDK140.83527917
72SRPK10.81625665
73CDK70.81119285
74BMX0.80163985
75AURKA0.79325873
76BCKDK0.77141088
77CHEK10.76861211
78TESK10.76803323
79KIT0.75203351
80FGFR10.74983149
81NUAK10.74267393
82PLK10.74120740
83CDK11A0.72803079
84LMTK20.72286780
85CDK150.71601242
86EPHA20.70376931
87ROCK20.70342455
88CDK180.69787038
89STK240.69257443
90STK30.65240110
91PLK20.65092777
92MTOR0.63384704
93TIE10.63321168
94NME20.55873405
95ADRBK10.55203463
96MAP3K30.54394119
97AURKB0.54070747
98CSF1R0.53842471
99UHMK10.53496495
100MAP3K50.52788185
101CAMKK10.51591452
102JAK30.50879737
103FGFR20.50390013
104DAPK30.50066583
105CDK20.49626848
106PRKD30.48337379
107MAP3K40.46877607
108SCYL20.46864120
109PTK20.46851034
110MAP3K70.46493046
111ARAF0.46039526
112MAPK110.46024404
113ERBB20.44953514
114PAK10.41825916
115PDGFRB0.41561893
116ALK0.41395565
117CLK10.40762697
118EGFR0.40411932
119TNIK0.39461778
120SIK30.39400245
121RIPK10.39228142
122SRC0.38938889
123CAMK1G0.38016429
124MARK30.37036924
125MAPKAPK20.36679716
126CDK10.36554346
127MAP2K10.36076260
128PAK60.35426214
129AKT20.35171248
130ATM0.34625893
131CAMK1D0.34410065
132CSNK1D0.33416323
133KSR20.32448607
134CASK0.32210432
135PLK30.32084793
136MET0.31914130
137CSNK2A10.30993857
138DYRK1A0.30947039
139MATK0.29928819
140CSNK1E0.29150979
141MAP3K80.28504562
142CDK30.28368354
143MAP2K30.28361538
144PIK3CA0.28352350
145RPS6KA10.27568555
146FGFR30.27116452
147PRKAA10.26538851
148PRKDC0.25908125
149NTRK20.25830645
150NEK90.25325823
151KDR0.24945255
152IGF1R0.23670242
153EIF2AK20.23603266
154MAPK10.23479602
155EPHA30.23051763

Predicted pathways (KEGG)

RankGene SetZ-score
1Ribosome_Homo sapiens_hsa030104.69500400
2Proteasome_Homo sapiens_hsa030504.34110258
3Sulfur relay system_Homo sapiens_hsa041224.22055822
4Basal cell carcinoma_Homo sapiens_hsa052173.67220992
5ECM-receptor interaction_Homo sapiens_hsa045122.71883009
6Glycosaminoglycan degradation_Homo sapiens_hsa005312.71049298
7Hedgehog signaling pathway_Homo sapiens_hsa043402.60102700
8Proteoglycans in cancer_Homo sapiens_hsa052052.33354036
9Hippo signaling pathway_Homo sapiens_hsa043902.24543539
10RNA polymerase_Homo sapiens_hsa030202.14911546
11Focal adhesion_Homo sapiens_hsa045102.04313894
12Pyrimidine metabolism_Homo sapiens_hsa002401.99505110
13MicroRNAs in cancer_Homo sapiens_hsa052061.88685725
14Adherens junction_Homo sapiens_hsa045201.87711642
15Autoimmune thyroid disease_Homo sapiens_hsa053201.77212818
16Wnt signaling pathway_Homo sapiens_hsa043101.70943210
17Small cell lung cancer_Homo sapiens_hsa052221.65445139
18Bladder cancer_Homo sapiens_hsa052191.64069391
19Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa045501.62248071
20Taste transduction_Homo sapiens_hsa047421.58684562
21Vibrio cholerae infection_Homo sapiens_hsa051101.58446399
22Spliceosome_Homo sapiens_hsa030401.54859322
23Mismatch repair_Homo sapiens_hsa034301.51183125
24Pathways in cancer_Homo sapiens_hsa052001.50059473
25PI3K-Akt signaling pathway_Homo sapiens_hsa041511.48509456
26Thyroid cancer_Homo sapiens_hsa052161.45762597
27Chronic myeloid leukemia_Homo sapiens_hsa052201.43191863
28Tight junction_Homo sapiens_hsa045301.42118877
29Transcriptional misregulation in cancer_Homo sapiens_hsa052021.42043025
30Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa009701.41636373
31Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate_Homo sapiens_hsa005321.41059048
32Leukocyte transendothelial migration_Homo sapiens_hsa046701.40489347
33Bacterial invasion of epithelial cells_Homo sapiens_hsa051001.39182912
34Platelet activation_Homo sapiens_hsa046111.36511036
35Axon guidance_Homo sapiens_hsa043601.36267539
36AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa049331.35654861
37Melanogenesis_Homo sapiens_hsa049161.35210109
38DNA replication_Homo sapiens_hsa030301.34271331
39Cell cycle_Homo sapiens_hsa041101.33466505
40TGF-beta signaling pathway_Homo sapiens_hsa043501.31434923
41Fanconi anemia pathway_Homo sapiens_hsa034601.31250708
42Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030081.30172832
432-Oxocarboxylic acid metabolism_Homo sapiens_hsa012101.23797595
44Taurine and hypotaurine metabolism_Homo sapiens_hsa004301.21303984
45Progesterone-mediated oocyte maturation_Homo sapiens_hsa049141.20236090
46One carbon pool by folate_Homo sapiens_hsa006701.20034310
47Steroid biosynthesis_Homo sapiens_hsa001001.19719643
48HTLV-I infection_Homo sapiens_hsa051661.13638049
49RNA transport_Homo sapiens_hsa030131.13473068
50Arrhythmogenic right ventricular cardiomyopathy (ARVC)_Homo sapiens_hsa054121.13412484
51Amoebiasis_Homo sapiens_hsa051461.12436322
52Protein digestion and absorption_Homo sapiens_hsa049741.10340227
53Malaria_Homo sapiens_hsa051441.09863666
54Melanoma_Homo sapiens_hsa052181.04697392
55p53 signaling pathway_Homo sapiens_hsa041151.02133048
56Synthesis and degradation of ketone bodies_Homo sapiens_hsa000721.01583529
57Herpes simplex infection_Homo sapiens_hsa051680.95419111
58Rap1 signaling pathway_Homo sapiens_hsa040150.94483705
59N-Glycan biosynthesis_Homo sapiens_hsa005100.94222848
60Ubiquitin mediated proteolysis_Homo sapiens_hsa041200.92519011
61Systemic lupus erythematosus_Homo sapiens_hsa053220.91981008
62RIG-I-like receptor signaling pathway_Homo sapiens_hsa046220.91498116
63Lysine degradation_Homo sapiens_hsa003100.91259882
64Cyanoamino acid metabolism_Homo sapiens_hsa004600.91052617
65Notch signaling pathway_Homo sapiens_hsa043300.89392399
66Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005330.89077259
67Regulation of actin cytoskeleton_Homo sapiens_hsa048100.87011614
68Phototransduction_Homo sapiens_hsa047440.86706730
69Protein export_Homo sapiens_hsa030600.86139493
70Hepatitis C_Homo sapiens_hsa051600.84653178
71AMPK signaling pathway_Homo sapiens_hsa041520.84031238
72Viral carcinogenesis_Homo sapiens_hsa052030.83584442
73Hepatitis B_Homo sapiens_hsa051610.82080477
74Colorectal cancer_Homo sapiens_hsa052100.81971328
75Glioma_Homo sapiens_hsa052140.81384354
76Pathogenic Escherichia coli infection_Homo sapiens_hsa051300.80226801
77Prostate cancer_Homo sapiens_hsa052150.80107891
78Other glycan degradation_Homo sapiens_hsa005110.80067556
79mRNA surveillance pathway_Homo sapiens_hsa030150.76873334
80Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007600.75833447
81Ascorbate and aldarate metabolism_Homo sapiens_hsa000530.74892306
82Renal cell carcinoma_Homo sapiens_hsa052110.74824032
83Cocaine addiction_Homo sapiens_hsa050300.74822682
84Gap junction_Homo sapiens_hsa045400.71476641
85Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001300.70304064
86Viral myocarditis_Homo sapiens_hsa054160.69856655
87Nucleotide excision repair_Homo sapiens_hsa034200.69616569
88Retinol metabolism_Homo sapiens_hsa008300.68333396
89Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa005340.68122756
90Cysteine and methionine metabolism_Homo sapiens_hsa002700.67753977
91Chemical carcinogenesis_Homo sapiens_hsa052040.64598405
92Base excision repair_Homo sapiens_hsa034100.63619385
93Other types of O-glycan biosynthesis_Homo sapiens_hsa005140.62673935
94Renin-angiotensin system_Homo sapiens_hsa046140.61718572
95Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006010.59843403
96ErbB signaling pathway_Homo sapiens_hsa040120.59463106
97Biosynthesis of amino acids_Homo sapiens_hsa012300.59272441
98Epstein-Barr virus infection_Homo sapiens_hsa051690.59141021
99Choline metabolism in cancer_Homo sapiens_hsa052310.59011084
100Selenocompound metabolism_Homo sapiens_hsa004500.59008262
101Hypertrophic cardiomyopathy (HCM)_Homo sapiens_hsa054100.57982066
102Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa051200.57675402
103Jak-STAT signaling pathway_Homo sapiens_hsa046300.57171786
104Salmonella infection_Homo sapiens_hsa051320.56226140
105Serotonergic synapse_Homo sapiens_hsa047260.55873464
106Non-small cell lung cancer_Homo sapiens_hsa052230.54599879
107Pancreatic cancer_Homo sapiens_hsa052120.53902870
108Shigellosis_Homo sapiens_hsa051310.53545362
109Neurotrophin signaling pathway_Homo sapiens_hsa047220.53439929
110Dilated cardiomyopathy_Homo sapiens_hsa054140.52178294
111Purine metabolism_Homo sapiens_hsa002300.51432392
112Ras signaling pathway_Homo sapiens_hsa040140.50786508
113Tuberculosis_Homo sapiens_hsa051520.49398619
114Glutathione metabolism_Homo sapiens_hsa004800.48658323
115Measles_Homo sapiens_hsa051620.48381555
116Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008600.48201621
117Vasopressin-regulated water reabsorption_Homo sapiens_hsa049620.46597896
118Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009800.46286962
119Folate biosynthesis_Homo sapiens_hsa007900.46184010
120Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006300.45074717
121Acute myeloid leukemia_Homo sapiens_hsa052210.44623695
122Alcoholism_Homo sapiens_hsa050340.44224088
123Central carbon metabolism in cancer_Homo sapiens_hsa052300.44077422
124B cell receptor signaling pathway_Homo sapiens_hsa046620.41104082
125Toxoplasmosis_Homo sapiens_hsa051450.40656645
126Oocyte meiosis_Homo sapiens_hsa041140.40134584
127Glucagon signaling pathway_Homo sapiens_hsa049220.40105427
128Long-term depression_Homo sapiens_hsa047300.40074348
129Protein processing in endoplasmic reticulum_Homo sapiens_hsa041410.38574689
130Cell adhesion molecules (CAMs)_Homo sapiens_hsa045140.38269466
131Galactose metabolism_Homo sapiens_hsa000520.38171896
132Non-homologous end-joining_Homo sapiens_hsa034500.37617264
133Drug metabolism - other enzymes_Homo sapiens_hsa009830.36625796
134Endometrial cancer_Homo sapiens_hsa052130.35901243
135Valine, leucine and isoleucine degradation_Homo sapiens_hsa002800.34684281
136Cytokine-cytokine receptor interaction_Homo sapiens_hsa040600.34212838
137Legionellosis_Homo sapiens_hsa051340.33058079
138Arginine and proline metabolism_Homo sapiens_hsa003300.29058182
139Terpenoid backbone biosynthesis_Homo sapiens_hsa009000.25665655
140Glycine, serine and threonine metabolism_Homo sapiens_hsa002600.25040337

Most similar genes based on co-expression Upload to Enrichr

Tissue Expression Export image »

Cell Line Expression Export image »