HOXA3

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: In vertebrates, the genes encoding the class of transcription factors called homeobox genes are found in clusters named A, B, C, and D on four separate chromosomes. Expression of these proteins is spatially and temporally regulated during embryonic development. This gene is part of the A cluster on chromosome 7 and encodes a DNA-binding transcription factor which may regulate gene expression, morphogenesis, and differentiation. Three transcript variants encoding two different isoforms have been found for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1definitive hemopoiesis (GO:0060216)5.55606315
2mesenchymal-epithelial cell signaling (GO:0060638)5.26542215
3regulation of single stranded viral RNA replication via double stranded DNA intermediate (GO:00450915.11845471
4outer ear morphogenesis (GO:0042473)5.09458082
5respiratory tube development (GO:0030323)4.76804672
6mesenchymal cell differentiation involved in renal system development (GO:2001012)4.38021948
7mesenchymal cell differentiation involved in kidney development (GO:0072161)4.38021948
8cartilage morphogenesis (GO:0060536)4.37870022
9cell differentiation involved in metanephros development (GO:0072202)4.31460175
10desmosome organization (GO:0002934)4.20919842
11regulation of mesenchymal cell apoptotic process (GO:2001053)4.10965768
12neural crest cell development (GO:0014032)4.07122638
13ribosomal small subunit assembly (GO:0000028)3.97892703
14facial nerve structural organization (GO:0021612)3.95890907
15negative regulation of mesenchymal cell apoptotic process (GO:2001054)3.81663300
16regulation of mammary gland epithelial cell proliferation (GO:0033599)3.81429576
17embryonic heart tube development (GO:0035050)3.78656597
18embryonic forelimb morphogenesis (GO:0035115)3.78450732
19muscle organ morphogenesis (GO:0048644)3.77523245
20chondrocyte proliferation (GO:0035988)3.74934929
21megakaryocyte development (GO:0035855)3.72915897
22mesenchymal to epithelial transition involved in metanephros morphogenesis (GO:0003337)3.68418524
23negative regulation of phagocytosis (GO:0050765)3.55768283
24polyketide metabolic process (GO:0030638)3.55019170
25doxorubicin metabolic process (GO:0044598)3.55019170
26daunorubicin metabolic process (GO:0044597)3.55019170
27metanephric mesenchyme development (GO:0072075)3.51052146
28* organ formation (GO:0048645)3.50557570
29mesenchymal cell development (GO:0014031)3.47751236
30purine nucleotide salvage (GO:0032261)3.46623463
31lymph vessel development (GO:0001945)3.44018440
32cell proliferation involved in metanephros development (GO:0072203)3.43075884
33kidney mesenchyme development (GO:0072074)3.41762631
34negative regulation of DNA damage response, signal transduction by p53 class mediator (GO:0043518)3.39016816
35viral transcription (GO:0019083)3.38128746
36lymphoid progenitor cell differentiation (GO:0002320)3.37850048
37translational termination (GO:0006415)3.29529047
38ureteric bud development (GO:0001657)3.28129727
39mammary gland epithelial cell differentiation (GO:0060644)3.27283192
40regulation of branching involved in salivary gland morphogenesis (GO:0060693)3.27205574
41mesonephros development (GO:0001823)3.24799102
42embryonic viscerocranium morphogenesis (GO:0048703)3.21998564
43mesenchymal cell differentiation (GO:0048762)3.21710190
44negative regulation of erythrocyte differentiation (GO:0045647)3.21310954
45pseudouridine synthesis (GO:0001522)3.20754488
46* embryonic organ morphogenesis (GO:0048562)3.20414596
47mesodermal cell differentiation (GO:0048333)3.18480081
48forelimb morphogenesis (GO:0035136)3.16588706
49muscle cell fate commitment (GO:0042693)3.14228970
50deoxyribonucleoside monophosphate metabolic process (GO:0009162)3.13516853
51negative regulation of B cell apoptotic process (GO:0002903)3.12917075
52platelet dense granule organization (GO:0060155)3.12193582
53mesonephric tubule development (GO:0072164)3.11385888
54regulation of heart morphogenesis (GO:2000826)3.09995846
55response to UV-B (GO:0010224)3.06009332
56negative regulation of chondrocyte differentiation (GO:0032331)3.05382929
57nephron tubule formation (GO:0072079)3.05043271
58middle ear morphogenesis (GO:0042474)3.03587660
59regulation of cardioblast differentiation (GO:0051890)3.02682144
60blood vessel maturation (GO:0001955)3.00754361
61mesonephric epithelium development (GO:0072163)3.00392620
62cell proliferation involved in kidney development (GO:0072111)2.98699334
63regulation of B cell apoptotic process (GO:0002902)2.98106246
64* embryonic skeletal system morphogenesis (GO:0048704)2.95001747
65maturation of 5.8S rRNA (GO:0000460)2.94243390
66glucocorticoid receptor signaling pathway (GO:0042921)2.93656354
67stem cell development (GO:0048864)2.93481548
68pattern specification involved in kidney development (GO:0061004)2.93167094
69planar cell polarity pathway involved in neural tube closure (GO:0090179)2.88742985
70fat-soluble vitamin catabolic process (GO:0042363)2.88728012
71vitamin catabolic process (GO:0009111)2.88728012
72regulation of stem cell maintenance (GO:2000036)2.88312863
73cranial nerve structural organization (GO:0021604)2.86015976
74regulation of apoptotic process involved in morphogenesis (GO:1902337)2.83569630
75lung-associated mesenchyme development (GO:0060484)2.82523176
76glomerulus development (GO:0032835)2.82157811
77embryonic skeletal joint morphogenesis (GO:0060272)2.79696301
78negative regulation of vascular endothelial growth factor receptor signaling pathway (GO:0030948)2.79047270
79lung vasculature development (GO:0060426)2.78254756
80regulation of establishment of planar polarity involved in neural tube closure (GO:0090178)2.77570246
81ribosomal small subunit biogenesis (GO:0042274)2.76669111
82osteoblast development (GO:0002076)2.76493557
83cell differentiation involved in kidney development (GO:0061005)2.75792501
84proximal/distal pattern formation (GO:0009954)2.74846441
85germ cell migration (GO:0008354)2.74728749
86lung secretory cell differentiation (GO:0061140)2.73616350
87regulation of organ formation (GO:0003156)2.71380569
88protein heterotrimerization (GO:0070208)2.71161913
89cell migration involved in heart development (GO:0060973)2.69451710
90negative regulation of epidermis development (GO:0045683)2.69232130
91translational elongation (GO:0006414)2.69218035
92somatic stem cell division (GO:0048103)2.68448888
93negative regulation of phosphatidylinositol 3-kinase signaling (GO:0014067)2.67557138
94regulation of secondary heart field cardioblast proliferation (GO:0003266)2.67306183
95regulation of cardioblast proliferation (GO:0003264)2.67306183
96nuclear-transcribed mRNA catabolic process, nonsense-mediated decay (GO:0000184)2.64464517
97rRNA modification (GO:0000154)2.64070550
98white fat cell differentiation (GO:0050872)2.62084468
99negative regulation of cell size (GO:0045792)2.61502360
100SRP-dependent cotranslational protein targeting to membrane (GO:0006614)2.60569861
101DNA damage response, detection of DNA damage (GO:0042769)2.60332300
102transcription from mitochondrial promoter (GO:0006390)2.60111962
103aminoglycoside antibiotic metabolic process (GO:0030647)2.59898564
104positive regulation of receptor biosynthetic process (GO:0010870)2.59597291
105pharyngeal system development (GO:0060037)2.59535296
106negative regulation of smooth muscle cell differentiation (GO:0051151)2.58449879
107regulation of odontogenesis (GO:0042481)2.58155775
108positive regulation of chondrocyte differentiation (GO:0032332)2.57991982
109diaphragm development (GO:0060539)2.57391488
110lens fiber cell differentiation (GO:0070306)2.57289000
111regulation of vitamin D biosynthetic process (GO:0060556)2.57019755
112* anterior/posterior pattern specification (GO:0009952)2.56197853
113regulation of vitamin metabolic process (GO:0030656)2.55795446
114alternative mRNA splicing, via spliceosome (GO:0000380)2.55550590
115cochlea morphogenesis (GO:0090103)2.54945824
116* skeletal system morphogenesis (GO:0048705)2.54891723
117mesenchymal to epithelial transition (GO:0060231)2.54395288
118* thyroid gland development (GO:0030878)2.54273484
119rRNA methylation (GO:0031167)2.53948610
120forebrain morphogenesis (GO:0048853)2.52850681
121hepatocyte differentiation (GO:0070365)2.52818335
122pteridine-containing compound biosynthetic process (GO:0042559)2.52560635
123bone trabecula formation (GO:0060346)2.51775457
124cotranslational protein targeting to membrane (GO:0006613)2.51674798
125prostate epithelial cord arborization involved in prostate glandular acinus morphogenesis (GO:0060522.50934194
126regulation of keratinocyte proliferation (GO:0010837)2.50713107
127sequestering of extracellular ligand from receptor (GO:0035581)2.50699287
128RNA methylation (GO:0001510)2.50005021
129organ induction (GO:0001759)2.49877753
130regulation of branching involved in ureteric bud morphogenesis (GO:0090189)2.49794304
131embryonic camera-type eye development (GO:0031076)2.49775892
132protein targeting to ER (GO:0045047)2.49580825
133peripheral nervous system neuron development (GO:0048935)2.49558714
134kidney epithelium development (GO:0072073)2.48839922
135positive regulation of fatty acid beta-oxidation (GO:0032000)2.48097297
136negative regulation of stem cell proliferation (GO:2000647)2.47759200
137embryonic cranial skeleton morphogenesis (GO:0048701)2.47502884
138cellular protein complex disassembly (GO:0043624)2.47433960
139urogenital system development (GO:0001655)2.47311422
140nucleotide salvage (GO:0043173)2.46661087
141artery development (GO:0060840)2.46415119
142regulation of Wnt signaling pathway, planar cell polarity pathway (GO:2000095)2.46298383
143paraxial mesoderm development (GO:0048339)2.45667501
144receptor guanylyl cyclase signaling pathway (GO:0007168)2.45411538
145hemidesmosome assembly (GO:0031581)2.45293519
146regulation of non-canonical Wnt signaling pathway (GO:2000050)2.45228284
147outflow tract septum morphogenesis (GO:0003148)2.39844019
148metanephros development (GO:0001656)2.38445819
149positive regulation of fatty acid oxidation (GO:0046321)2.37662914
150AMP metabolic process (GO:0046033)2.37499691
151respiratory system process (GO:0003016)2.35643474
152erythrose 4-phosphate/phosphoenolpyruvate family amino acid metabolic process (GO:1902221)2.34501679
153L-phenylalanine metabolic process (GO:0006558)2.34501679
154positive regulation of branching involved in ureteric bud morphogenesis (GO:0090190)2.33995721
155galactose metabolic process (GO:0006012)2.32444118
156regulation of cell aging (GO:0090342)2.30731357
157nucleoside salvage (GO:0043174)2.30334135
158regulation of cellular senescence (GO:2000772)2.29473534
159negative regulation of cell cycle arrest (GO:0071157)2.28182011
160positive regulation of fatty acid metabolic process (GO:0045923)2.27053266
161regulation of histone phosphorylation (GO:0033127)2.26384471
162negative regulation of kidney development (GO:0090185)2.26314023
163* cranial nerve morphogenesis (GO:0021602)2.25658787
164negative regulation of cell aging (GO:0090344)2.24348744
165tooth mineralization (GO:0034505)2.23202538
166viral mRNA export from host cell nucleus (GO:0046784)2.22710739
167mitochondrial RNA metabolic process (GO:0000959)2.22578353
168bundle of His cell to Purkinje myocyte communication (GO:0086069)2.22450845
169fertilization (GO:0009566)2.19703257
170negative regulation of keratinocyte proliferation (GO:0010839)2.18761999
171formation of translation preinitiation complex (GO:0001731)2.17642549

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse6.77558982
2E2F7_22180533_ChIP-Seq_HELA_Human5.12230451
3* CHD7_19251738_ChIP-ChIP_MESCs_Mouse5.11890262
4TP63_19390658_ChIP-ChIP_HaCaT_Human4.39148763
5TP63_17297297_ChIP-ChIP_HaCaT_Human4.35633036
6SCL_19346495_ChIP-Seq_HPC-7_Human3.96284055
7RBPJ_22232070_ChIP-Seq_NCS_Mouse3.51391974
8PPARG_19300518_ChIP-PET_3T3-L1_Mouse3.18448702
9FOXM1_23109430_ChIP-Seq_U2OS_Human3.07506515
10TRP63_18441228_ChIP-ChIP_KERATINOCYTES_Mouse2.81750586
11ESR1_15608294_ChIP-ChIP_MCF-7_Human2.77528419
12FOXM1_25889361_ChIP-Seq_OE33_AND_U2OS_Human2.70639046
13IRF8_22096565_ChIP-ChIP_GC-B_Human2.42653533
14CEBPD_21427703_ChIP-Seq_3T3-L1_Mouse2.37791263
15BP1_19119308_ChIP-ChIP_Hs578T_Human2.37033103
16FOXP3_17237761_ChIP-ChIP_TREG_Mouse2.35465451
17SOX9_22984422_ChIP-ChIP_TESTIS_Rat2.32903586
18E2F4_17652178_ChIP-ChIP_JURKAT_Human2.29010423
19ESR1_17901129_ChIP-ChIP_LIVER_Mouse2.22795402
20ZNF263_19887448_ChIP-Seq_K562_Human2.19952363
21SMAD4_19686287_ChIP-ChIP_HaCaT_Human2.16828426
22TRIM28_21343339_ChIP-Seq_HEK293_Human2.16824164
23NOTCH1_21737748_ChIP-Seq_TLL_Human2.15766336
24MYC_18555785_ChIP-Seq_MESCs_Mouse2.11133995
25JARID1A_20064375_ChIP-Seq_MESCs_Mouse2.05504767
26HNF4A_19761587_ChIP-ChIP_CACO-2_Human2.02808564
27EGR1_19374776_ChIP-ChIP_THP-1_Human1.93927225
28RUNX1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.86047973
29GATA6_25053715_ChIP-Seq_YYC3_Human1.84298561
30RARG_19884340_ChIP-ChIP_MEFs_Mouse1.80254217
31PRDM16_22522345_ChIP-ChIP_PALATE_MESENCHYMAL_Mouse1.79034159
32DACH1_20351289_ChIP-Seq_MDA-MB-231_Human1.78722393
33TAF7L_23326641_ChIP-Seq_C3H10T1-2_Mouse1.76471752
34AR_21909140_ChIP-Seq_LNCAP_Human1.75035114
35ELK1_19687146_ChIP-ChIP_HELA_Human1.72920978
36WT1_19549856_ChIP-ChIP_CCG9911_Human1.72398243
37HOXD13_18407260_ChIP-ChIP_DEVELOPING-LIMBS_Mouse1.71499931
38* SMAD3_18955504_ChIP-ChIP_HaCaT_Human1.70846914
39* SMAD2_18955504_ChIP-ChIP_HaCaT_Human1.70846914
40* POU5F1_16153702_ChIP-ChIP_HESCs_Human1.69720306
41* PHC1_16625203_ChIP-ChIP_MESCs_Mouse1.69038070
42RUNX2_24764292_ChIP-Seq_MC3T3_Mouse1.67164105
43DCP1A_22483619_ChIP-Seq_HELA_Human1.66109569
44GATA4_25053715_ChIP-Seq_YYC3_Human1.65739839
45MYC_18358816_ChIP-ChIP_MESCs_Mouse1.64643357
46FUS_26573619_Chip-Seq_HEK293_Human1.63203444
47STAT6_21828071_ChIP-Seq_BEAS2B_Human1.61184767
48TAL1_20887958_ChIP-Seq_HPC-7_Mouse1.59067910
49GLI1_17442700_ChIP-ChIP_MESCs_Mouse1.57649884
50* BMI1_23680149_ChIP-Seq_NPCS_Mouse1.57616229
51E2F1_21310950_ChIP-Seq_MCF-7_Human1.56795845
52BRD4_25478319_ChIP-Seq_HGPS_Human1.56735672
53* TET1_21451524_ChIP-Seq_MESCs_Mouse1.54035864
54ETS1_20019798_ChIP-Seq_JURKAT_Human1.52645525
55EWS_26573619_Chip-Seq_HEK293_Human1.52545789
56VDR_21846776_ChIP-Seq_THP-1_Human1.50995425
57RXR_22158963_ChIP-Seq_LIVER_Mouse1.48798113
58PPAR_26484153_Chip-Seq_NCI-H1993_Human1.47933093
59SOX2_18555785_ChIP-Seq_MESCs_Mouse1.47813266
60FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse1.47692936
61* SREBP2_21459322_ChIP-Seq_LIVER_Mouse1.43935271
62* KLF6_26769127_Chip-Seq_PDAC-Cell_line_Human1.43534739
63ESR1_21235772_ChIP-Seq_MCF-7_Human1.43474965
64SOX2_20726797_ChIP-Seq_SW620_Human1.40563391
65* CDX2_20551321_ChIP-Seq_CACO-2_Human1.40403514
66* CEBPB_21427703_ChIP-Seq_3T3-L1_Mouse1.40276100
67* EED_16625203_ChIP-ChIP_MESCs_Mouse1.39941005
68* RNF2_16625203_ChIP-ChIP_MESCs_Mouse1.39756283
69MYC_22102868_ChIP-Seq_BL_Human1.39103485
70RUNX1_20887958_ChIP-Seq_HPC-7_Mouse1.38409845
71* TP53_22127205_ChIP-Seq_IMR90_Human1.37711083
72PPARD_23176727_ChIP-Seq_KERATINOCYTES_Mouse1.36927184
73MECOM_23826213_ChIP-Seq_KASUMI_Mouse1.36365803
74* UBF1/2_26484160_Chip-Seq_HMECs_Human1.36160013
75GATA2_21666600_ChIP-Seq_HMVEC_Human1.35844701
76PPARA_22158963_ChIP-Seq_LIVER_Mouse1.35625051
77SOX9_24532713_ChIP-Seq_HFSC_Mouse1.34982579
78WT1_20215353_ChIP-ChIP_NEPHRON_PROGENITOR_Mouse1.33195698
79MYC_18940864_ChIP-ChIP_HL60_Human1.33193116
80EP300_20729851_ChIP-Seq_FORBRAIN_MIDBRAIN_LIMB_HEART_Mouse1.32961852
81BCL3_23251550_ChIP-Seq_MUSCLE_Mouse1.32688555
82* ATF3_27146783_Chip-Seq_COLON_Human1.32016329
83MYBL1_21750041_ChIP-ChIP_SPERMATOCYTES_Mouse1.29564578
84TP53_20018659_ChIP-ChIP_R1E_Mouse1.29147647
85CEBPD_23245923_ChIP-Seq_MEFs_Mouse1.28446831
86TCF7_22412390_ChIP-Seq_EML_Mouse1.28309566
87HIF1A_21447827_ChIP-Seq_MCF-7_Human1.27887630
88ASXL1_24218140_ChIP-Seq_BMDM_Mouse1.27526659
89* PRDM5_23873026_ChIP-Seq_MEFs_Mouse1.27244078
90CIITA_18437201_ChIP-ChIP_Raji_B_and_iDC_Human1.26708111
91MYC_19030024_ChIP-ChIP_MESCs_Mouse1.25780140
92CEBPA_23403033_ChIP-Seq_LIVER_Mouse1.24363306
93GFI1B_20887958_ChIP-Seq_HPC-7_Mouse1.23499639
94SPI1_22790984_ChIP-Seq_ERYTHROLEUKEMIA_Mouse1.23236965
95CIITA_25753668_ChIP-Seq_RAJI_Human1.22750389
96CJUN_26792858_Chip-Seq_BT549_Human1.22477688
97MYB_21317192_ChIP-Seq_ERMYB_Mouse1.22253365
98MEF2A_21415370_ChIP-Seq_HL-1_Mouse1.22162306
99LYL1_20887958_ChIP-Seq_HPC-7_Mouse1.21767331
100TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat1.21424864
101GABP_17652178_ChIP-ChIP_JURKAT_Human1.20555449
102KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human1.20519928
103CBX2_27304074_Chip-Seq_ESCs_Mouse1.20297061
104EGR1_23403033_ChIP-Seq_LIVER_Mouse1.19717570
105TTF2_22483619_ChIP-Seq_HELA_Human1.19692877
106* CDX2_19796622_ChIP-Seq_MESCs_Mouse1.19426460
107ESR1_20079471_ChIP-ChIP_T-47D_Human1.18706086
108ELK3_25401928_ChIP-Seq_HUVEC_Human1.18451034
109YY1_22570637_ChIP-Seq_MALME-3M_Human1.18212004
110TBP_23326641_ChIP-Seq_C3H10T1-2_Mouse1.17906575
111IRF8_22096565_ChIP-ChIP_GC-B_Mouse1.17877496
112GABP_19822575_ChIP-Seq_HepG2_Human1.16187109
113ERG_20887958_ChIP-Seq_HPC-7_Mouse1.15136305
114ISL1_27105846_Chip-Seq_CPCs_Mouse1.14795634
115* KLF4_26769127_Chip-Seq_PDAC-Cell_line_Human1.13885821
116PPARG_23326641_ChIP-Seq_C3H10T1-2_Mouse1.13323411
117PKCTHETA_26484144_Chip-Seq_BREAST_Human1.11996519
118ZNF652_21678463_ChIP-ChIP_ZR75-1_Human1.11862408
119XRN2_22483619_ChIP-Seq_HELA_Human1.08340827
120ELF1_17652178_ChIP-ChIP_JURKAT_Human1.08126835
121DMRT1_23473982_ChIP-Seq_TESTES_Mouse1.06701592
122NFIB_24661679_ChIP-Seq_LUNG_Mouse1.06213887
123VDR_24763502_ChIP-Seq_THP-1_Human1.05744749
124HCFC1_20581084_ChIP-Seq_MESCs_Mouse1.05368992
125RACK7_27058665_Chip-Seq_MCF-7_Human1.05024932
126FOXP3_21729870_ChIP-Seq_TREG_Human1.04487414
127ZFX_18555785_ChIP-Seq_MESCs_Mouse1.03791800
128STAT1_20625510_ChIP-Seq_HELA_Human1.02419156
129ESR1_22446102_ChIP-Seq_UTERUS_Mouse1.02104029
130FOXA1_27197147_Chip-Seq_ENDOMETRIOID-ADENOCARCINOMA_Human0.99765888
131ELF1_20517297_ChIP-Seq_JURKAT_Human0.99756093
132STAT6_20620947_ChIP-Seq_CD4_POS_T_Human0.99582953
133E2F1_18555785_ChIP-Seq_MESCs_Mouse0.98899247
134* MYBL2_22936984_ChIP-ChIP_MESCs_Mouse0.98833395
135NANOG_16153702_ChIP-ChIP_HESCs_Human0.97932960
136KLF5_18264089_ChIP-ChIP_MESCs_Mouse0.97084976
137KLF4_18264089_ChIP-ChIP_MESCs_Mouse0.97084976
138KLF2_18264089_ChIP-ChIP_MESCs_Mouse0.97084976
139IRF1_21803131_ChIP-Seq_MONOCYTES_Human0.96625385
140SRF_21415370_ChIP-Seq_HL-1_Mouse0.96248756
141ZNF274_21170338_ChIP-Seq_K562_Hela0.95764238
142LXR_22158963_ChIP-Seq_LIVER_Mouse0.95609965
143STAT3_20064451_ChIP-Seq_CD4+T_Mouse0.94952680
144ERA_27197147_Chip-Seq_ENDOMETRIOID-ADENOCARCINOMA_Human0.94767018
145* EP300_21415370_ChIP-Seq_HL-1_Mouse0.94336213
146P63_26484246_Chip-Seq_KERATINOCYTES_Human0.93696056
147SPI1_23547873_ChIP-Seq_NB4_Human0.93692748
148SFPI1_20887958_ChIP-Seq_HPC-7_Mouse0.92481347
149KDM5A_27292631_Chip-Seq_BREAST_Human0.92356168
150SA1_22415368_ChIP-Seq_MEFs_Mouse0.92036829
151NKX2-5_21415370_ChIP-Seq_HL-1_Mouse0.91712398
152* STAT3_19079543_ChIP-ChIP_MESCs_Mouse0.91486320
153CEBPB_24764292_ChIP-Seq_MC3T3_Mouse0.91372848
154* NFI_21473784_ChIP-Seq_ESCs_Mouse0.90945035
155KLF4_19030024_ChIP-ChIP_MESCs_Mouse0.90770372
156HOXB4_20404135_ChIP-ChIP_EML_Mouse0.90146925
157FOXO3_22982991_ChIP-Seq_MACROPHAGES_Mouse0.89675142
158HSF1_23293686_ChIP-Seq_STHDH_STRIATAL_Mouse0.89544001
159MYC_19079543_ChIP-ChIP_MESCs_Mouse0.88835319
160SPI1_22096565_ChIP-ChIP_GC-B_Mouse0.88752073
161RUNX1_22412390_ChIP-Seq_EML_Mouse0.87705225
162TP53_18474530_ChIP-ChIP_U2OS_Human0.87586183
163RNF2_27304074_Chip-Seq_NSC_Mouse0.86896263
164* KDM5B_21448134_ChIP-Seq_MESCs_Mouse0.86636254
165TCF21_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human0.86614627
166FOXM1_26100407_CHIP-SEQ_Hek293_flp-in_Human0.85025091
167FOXO1_25302145_ChIP-Seq_T-LYMPHOCYTE_Mouse0.84806636

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0005670_abnormal_white_adipose3.29335299
2MP0005360_urolithiasis3.24980861
3MP0010030_abnormal_orbit_morphology3.12977712
4MP0002396_abnormal_hematopoietic_system2.94266142
5MP0002160_abnormal_reproductive_system2.79702296
6* MP0002249_abnormal_larynx_morphology2.73603019
7MP0003941_abnormal_skin_development2.71330971
8MP0005503_abnormal_tendon_morphology2.63706730
9MP0010368_abnormal_lymphatic_system2.53617098
10MP0002009_preneoplasia2.39711189
11MP0002938_white_spotting2.37917440
12* MP0009250_abnormal_appendicular_skeleto2.35649127
13MP0001879_abnormal_lymphatic_vessel2.32313662
14MP0003283_abnormal_digestive_organ2.31980187
15* MP0002282_abnormal_trachea_morphology2.27244711
16MP0004808_abnormal_hematopoietic_stem2.24174440
17MP0002234_abnormal_pharynx_morphology2.18818737
18MP0000049_abnormal_middle_ear2.18314627
19MP0003385_abnormal_body_wall2.13489466
20MP0004782_abnormal_surfactant_physiolog2.09133822
21MP0003942_abnormal_urinary_system2.07055216
22MP0003279_aneurysm2.06736482
23MP0008438_abnormal_cutaneous_collagen2.03130569
24MP0005275_abnormal_skin_tensile1.98866602
25MP0006054_spinal_hemorrhage1.98255188
26MP0000537_abnormal_urethra_morphology1.95465732
27MP0001188_hyperpigmentation1.93185319
28MP0002139_abnormal_hepatobiliary_system1.92086101
29MP0008007_abnormal_cellular_replicative1.84858605
30MP0005623_abnormal_meninges_morphology1.82077109
31MP0002932_abnormal_joint_morphology1.80466736
32MP0000516_abnormal_urinary_system1.77149826
33MP0005367_renal/urinary_system_phenotyp1.77149826
34MP0003950_abnormal_plasma_membrane1.64881413
35* MP0005508_abnormal_skeleton_morphology1.63013576
36MP0003122_maternal_imprinting1.57821360
37MP0001661_extended_life_span1.56900526
38MP0003252_abnormal_bile_duct1.54955334
39MP0002177_abnormal_outer_ear1.50756500
40MP0004272_abnormal_basement_membrane1.50588328
41MP0003567_abnormal_fetal_cardiomyocyte1.49647445
42MP0003806_abnormal_nucleotide_metabolis1.47368927
43MP0000566_synostosis1.46816827
44MP0003705_abnormal_hypodermis_morpholog1.43093186
45MP0000003_abnormal_adipose_tissue1.42312978
46MP0005409_darkened_coat_color1.41154769
47MP0005646_abnormal_pituitary_gland1.40953359
48MP0000534_abnormal_ureter_morphology1.36727167
49MP0000467_abnormal_esophagus_morphology1.36552540
50MP0010352_gastrointestinal_tract_polyps1.35063177
51MP0002060_abnormal_skin_morphology1.34929568
52* MP0000678_abnormal_parathyroid_gland1.34643775
53MP0000465_gastrointestinal_hemorrhage1.34542508
54MP0003115_abnormal_respiratory_system1.34381117
55MP0003123_paternal_imprinting1.33646068
56MP0002138_abnormal_hepatobiliary_system1.31672908
57MP0002095_abnormal_skin_pigmentation1.30906199
58MP0001545_abnormal_hematopoietic_system1.29785869
59MP0005397_hematopoietic_system_phenotyp1.29785869
60* MP0000163_abnormal_cartilage_morphology1.27734757
61MP0003315_abnormal_perineum_morphology1.26179126
62MP0001958_emphysema1.24233355
63MP0001664_abnormal_digestion1.23953532
64* MP0000762_abnormal_tongue_morphology1.23872083
65MP0002109_abnormal_limb_morphology1.23007362
66* MP0003935_abnormal_craniofacial_develop1.21671684
67MP0001346_abnormal_lacrimal_gland1.21205136
68MP0000767_abnormal_smooth_muscle1.21131147
69MP0004134_abnormal_chest_morphology1.20725225
70MP0000733_abnormal_muscle_development1.20186589
71MP0000013_abnormal_adipose_tissue1.19985049
72* MP0003755_abnormal_palate_morphology1.19409325
73MP0003938_abnormal_ear_development1.18178079
74MP0003937_abnormal_limbs/digits/tail_de1.17991417
75MP0010234_abnormal_vibrissa_follicle1.16615298
76MP0005023_abnormal_wound_healing1.16062865
77MP0005389_reproductive_system_phenotype1.15400200
78MP0003943_abnormal_hepatobiliary_system1.14039542
79MP0005257_abnormal_intraocular_pressure1.13576342
80MP0000613_abnormal_salivary_gland1.13038773
81MP0002877_abnormal_melanocyte_morpholog1.12314895
82* MP0002114_abnormal_axial_skeleton1.11885201
83MP0009379_abnormal_foot_pigmentation1.11246661
84MP0002113_abnormal_skeleton_development1.10380862
85MP0002876_abnormal_thyroid_physiology1.08869507
86MP0004185_abnormal_adipocyte_glucose1.08138847
87MP0000428_abnormal_craniofacial_morphol1.07386084
88* MP0000681_abnormal_thyroid_gland1.06631827
89MP0010678_abnormal_skin_adnexa1.06439634
90MP0003111_abnormal_nucleus_morphology1.04774195
91MP0000490_abnormal_crypts_of1.04439192
92MP0008057_abnormal_DNA_replication1.03703555
93MP0002115_abnormal_skeleton_extremities1.03121573
94MP0003121_genomic_imprinting1.02357684
95MP0009053_abnormal_anal_canal1.02162018
96MP0003566_abnormal_cell_adhesion1.01461552
97MP0003718_maternal_effect1.00975354
98MP0002233_abnormal_nose_morphology1.00965437
99MP0010094_abnormal_chromosome_stability1.00911326
100MP0000432_abnormal_head_morphology1.00352252
101MP0002928_abnormal_bile_duct1.00106335
102MP0000383_abnormal_hair_follicle0.99692040
103MP0002102_abnormal_ear_morphology0.98843906
104MP0005410_abnormal_fertilization0.98278396
105* MP0002116_abnormal_craniofacial_bone0.98246503
106MP0003786_premature_aging0.97317357
107MP0002166_altered_tumor_susceptibility0.97152656
108MP0009278_abnormal_bone_marrow0.97023885
109MP0000538_abnormal_urinary_bladder0.95975274
110MP0009697_abnormal_copulation0.95247759
111MP0001849_ear_inflammation0.93962928
112* MP0002108_abnormal_muscle_morphology0.93871737
113MP0002111_abnormal_tail_morphology0.92407082
114MP0006292_abnormal_olfactory_placode0.91442763
115MP0000749_muscle_degeneration0.91124995
116* MP0001270_distended_abdomen0.90925605
117MP0001177_atelectasis0.89364713
118MP0008995_early_reproductive_senescence0.89332524
119MP0003191_abnormal_cellular_cholesterol0.88328835
120MP0002089_abnormal_postnatal_growth/wei0.88048445
121MP0002098_abnormal_vibrissa_morphology0.87475813
122* MP0005390_skeleton_phenotype0.86978837
123MP0002277_abnormal_respiratory_mucosa0.86273034
124MP0001764_abnormal_homeostasis0.86130236
125MP0002269_muscular_atrophy0.85786519
126MP0005375_adipose_tissue_phenotype0.85461939
127MP0005174_abnormal_tail_pigmentation0.85266944
128MP0001293_anophthalmia0.83656842
129* MP0002925_abnormal_cardiovascular_devel0.82922757
130MP0001915_intracranial_hemorrhage0.82882868
131MP0004197_abnormal_fetal_growth/weight/0.82290960
132MP0001175_abnormal_lung_morphology0.81791205
133MP0001881_abnormal_mammary_gland0.80435650
134MP0005084_abnormal_gallbladder_morpholo0.80421116
135MP0003828_pulmonary_edema0.78774625
136MP0002128_abnormal_blood_circulation0.78447880
137MP0005451_abnormal_body_composition0.76713310
138MP0000427_abnormal_hair_cycle0.76596595
139* MP0001614_abnormal_blood_vessel0.75877801
140MP0005076_abnormal_cell_differentiation0.75618707
141MP0004233_abnormal_muscle_weight0.75321871
142MP0008932_abnormal_embryonic_tissue0.74967989
143MP0003693_abnormal_embryo_hatching0.74499757
144MP0001873_stomach_inflammation0.73889292
145MP0005666_abnormal_adipose_tissue0.70438223
146MP0005332_abnormal_amino_acid0.69381417
147MP0000653_abnormal_sex_gland0.68268759
148MP0006036_abnormal_mitochondrial_physio0.67680915
149MP0001145_abnormal_male_reproductive0.67076073
150MP0000627_abnormal_mammary_gland0.66947375

Predicted human phenotypes

RankGene SetZ-score
1Abnormal umbilical cord blood vessels (HP:0011403)4.06108231
2Single umbilical artery (HP:0001195)4.06108231
3Abnormality of the fetal cardiovascular system (HP:0010948)4.06108231
4Spinal cord lesions (HP:0100561)3.87010217
5Syringomyelia (HP:0003396)3.87010217
6White forelock (HP:0002211)3.49516621
7Microretrognathia (HP:0000308)3.42106011
8Patchy hypopigmentation of hair (HP:0011365)3.34880491
9Short 4th metacarpal (HP:0010044)3.22742598
10Aplasia/Hypoplasia of the 4th metacarpal (HP:0010042)3.22742598
11Protrusio acetabuli (HP:0003179)3.21456139
12Neonatal short-limb short stature (HP:0008921)3.11577427
13Bell-shaped thorax (HP:0001591)3.05677727
14Shallow orbits (HP:0000586)2.94222519
15Septate vagina (HP:0001153)2.92671362
16Abnormality of the phalanges of the hallux (HP:0010057)2.86469805
17Short middle phalanx of the 5th finger (HP:0004220)2.85130665
18Abnormality of the umbilical cord (HP:0010881)2.76352972
19Reduced subcutaneous adipose tissue (HP:0003758)2.74768789
20Absent phalangeal crease (HP:0006109)2.73771241
21Broad metatarsal (HP:0001783)2.73408960
22Periauricular skin pits (HP:0100277)2.68245598
23Preauricular pit (HP:0004467)2.68245598
24Mesomelia (HP:0003027)2.64957453
25Ankle contracture (HP:0006466)2.64924437
26Hypoplastic left heart (HP:0004383)2.63523657
27Renal duplication (HP:0000075)2.62600321
28Selective tooth agenesis (HP:0001592)2.61174634
29Birth length less than 3rd percentile (HP:0003561)2.56307236
30Sensory axonal neuropathy (HP:0003390)2.55647221
31Popliteal pterygium (HP:0009756)2.55277668
32Abnormality of the parietal bone (HP:0002696)2.53307867
33Follicular hyperkeratosis (HP:0007502)2.51884375
34Abnormality of the columella (HP:0009929)2.51548589
35Asymmetry of the thorax (HP:0001555)2.50642728
36Type I transferrin isoform profile (HP:0003642)2.46326894
37Reduced antithrombin III activity (HP:0001976)2.45295890
38Spondylolisthesis (HP:0003302)2.45213660
39Abnormality of the nasolacrimal system (HP:0000614)2.43062223
40Hypoplastic heart (HP:0001961)2.41417641
41Nasolacrimal duct obstruction (HP:0000579)2.33965116
42Abnormality of the 4th metacarpal (HP:0010012)2.33604269
43Distal arthrogryposis (HP:0005684)2.33193863
44Atrophic scars (HP:0001075)2.30152865
45Down-sloping shoulders (HP:0200021)2.25134637
46Metaphyseal dysplasia (HP:0100255)2.23636353
47Abnormality of the phalanges of the 2nd finger (HP:0009541)2.22109296
48Tracheomalacia (HP:0002779)2.21105569
49Acute myeloid leukemia (HP:0004808)2.19260586
50Thin bony cortex (HP:0002753)2.18586717
51Congenital malformation of the right heart (HP:0011723)2.18412725
52Double outlet right ventricle (HP:0001719)2.18412725
53Abnormality of the lacrimal duct (HP:0011481)2.13882190
54Abnormality of the nasal septum (HP:0000419)2.13757594
55Gout (HP:0001997)2.11999862
56Pigmentary retinal degeneration (HP:0001146)2.11003726
57Acute lymphatic leukemia (HP:0006721)2.08877107
58Heterochromia iridis (HP:0001100)2.08565234
59Abnormal finger flexion creases (HP:0006143)2.08383419
60Cervical subluxation (HP:0003308)2.07944608
61Squamous cell carcinoma (HP:0002860)2.04994931
62Broad palm (HP:0001169)2.04004874
63Abnormal protein glycosylation (HP:0012346)2.03912241
64Abnormal glycosylation (HP:0012345)2.03912241
65Abnormal isoelectric focusing of serum transferrin (HP:0003160)2.03912241
66Abnormal protein N-linked glycosylation (HP:0012347)2.03912241
67Abnormal lung lobation (HP:0002101)2.03460057
68Midline defect of the nose (HP:0004122)2.03150568
69Premature rupture of membranes (HP:0001788)2.02831092
70Abnormal tarsal ossification (HP:0008369)2.01735091
71Soft skin (HP:0000977)2.01535571
72Rectal prolapse (HP:0002035)2.01219110
73Transposition of the great arteries (HP:0001669)1.99498588
74Abnormal connection of the cardiac segments (HP:0011545)1.99498588
75Abnormal ventriculo-arterial connection (HP:0011563)1.99498588
76Slender build (HP:0001533)1.98369307
77Abnormality of the proximal phalanges of the hand (HP:0009834)1.97987703
78Abnormality of aromatic amino acid family metabolism (HP:0004338)1.97740693
79Renal dysplasia (HP:0000110)1.97469624
80Abnormality of carpal bone ossification (HP:0006257)1.97363188
81Thrombocytosis (HP:0001894)1.97331019
82Embryonal renal neoplasm (HP:0011794)1.96104133
83Morphological abnormality of the middle ear (HP:0008609)1.95809339
84Trismus (HP:0000211)1.94495988
85Missing ribs (HP:0000921)1.93635331
86Skin pits (HP:0100276)1.93198519
8711 pairs of ribs (HP:0000878)1.92544886
88Reticulocytopenia (HP:0001896)1.91088243
89Spinal rigidity (HP:0003306)1.91016888
90Unilateral renal agenesis (HP:0000122)1.90938843
91Aplasia/Hypoplasia of the sacrum (HP:0008517)1.90662725
92Fragile skin (HP:0001030)1.89484569
93Aortic valve stenosis (HP:0001650)1.88675488
94Aplasia cutis congenita (HP:0001057)1.88287641
95Cutaneous melanoma (HP:0012056)1.87997160
96Abnormality of the phalanges of the 5th finger (HP:0004213)1.87680822
97Neonatal respiratory distress (HP:0002643)1.86690160
98Abnormality of incisor morphology (HP:0011063)1.86558075
99Spontaneous abortion (HP:0005268)1.86518138
100Increased density of long bones (HP:0006392)1.85960862
101Abnormality of the distal phalanges of the toes (HP:0010182)1.84527362
102Decreased skull ossification (HP:0004331)1.84428836
103Diastasis recti (HP:0001540)1.84325343
104Absent thumb (HP:0009777)1.84172091
105Abnormalities of placenta or umbilical cord (HP:0001194)1.83541461
106Aplastic anemia (HP:0001915)1.83487062
107Germ cell neoplasia (HP:0100728)1.82231194
108Abnormality of dentin (HP:0010299)1.81689404
109Abnormal number of incisors (HP:0011064)1.81495632
110Lip pit (HP:0100267)1.81432912
111Abnormality of the 2nd finger (HP:0004100)1.80906726
112Bicornuate uterus (HP:0000813)1.80684891
113Abnormality of the middle phalanx of the 5th finger (HP:0004219)1.80075451
114Weak cry (HP:0001612)1.79854296
115Bowel diverticulosis (HP:0005222)1.79779078
116Short 5th finger (HP:0009237)1.79670387
117Sprengel anomaly (HP:0000912)1.79439951
118Conical tooth (HP:0000698)1.79296924
119Redundant skin (HP:0001582)1.77817901
120Breast hypoplasia (HP:0003187)1.77114157
121Aortic aneurysm (HP:0004942)1.76743228
122Absent frontal sinuses (HP:0002688)1.75815211
123Delayed closure of the anterior fontanelle (HP:0001476)1.75592814
124Rectal fistula (HP:0100590)1.75486013
125Rectovaginal fistula (HP:0000143)1.75486013
126Sparse lateral eyebrow (HP:0005338)1.75253498
127Aplasia/Hypoplasia of the phalanges of the 5th finger (HP:0009376)1.74391859
128Natal tooth (HP:0000695)1.74303121
129Congenital sensorineural hearing impairment (HP:0008527)1.72366218
130Broad toe (HP:0001837)1.71968889
131Abnormality of the incisor (HP:0000676)1.70875630
132Hypoplasia of the uterus (HP:0000013)1.69360657
133Pterygium (HP:0001059)1.68305824
134Aortic dissection (HP:0002647)1.67222384
135Abnormality of the distal phalanx of the thumb (HP:0009617)1.66474819
136Bronchomalacia (HP:0002780)1.66151601
137Elbow flexion contracture (HP:0002987)1.65229224
138Anal stenosis (HP:0002025)1.64589207
139Broad long bones (HP:0005622)1.64275363
140Aplasia/Hypoplasia of the middle phalanx of the 5th finger (HP:0009161)1.64195606
141Round ear (HP:0100830)1.62503681
142Bladder diverticulum (HP:0000015)1.62480861
143Myopathic facies (HP:0002058)1.61638183
144Progressive muscle weakness (HP:0003323)1.61511127
145Facial cleft (HP:0002006)1.60915310
146Abnormality of the costochondral junction (HP:0000919)1.60643328
147Broad phalanx (HP:0006009)1.60631393
148Hyperuricemia (HP:0002149)1.60476945
149Increased purine levels (HP:0004368)1.60476945
150Hypoplastic iliac wings (HP:0002866)1.59835896
151Type 1 muscle fiber predominance (HP:0003803)1.59389109
152Abnormality of skeletal muscle fiber size (HP:0012084)1.59250935
153Cupped ribs (HP:0000887)1.59000086
154Pulmonary artery stenosis (HP:0004415)1.58746914
155Abnormality of the acetabulum (HP:0003170)1.58648385
156Intestinal fistula (HP:0100819)1.57112446
157Abnormality of the anterior chamber (HP:0000593)1.57110520
158Obstructive sleep apnea (HP:0002870)1.56672430
159Aplasia/Hypoplasia of the 5th finger (HP:0006262)1.56327994
160Absent eyebrow (HP:0002223)1.56119012
161Long nose (HP:0003189)1.55004483
162Myelomeningocele (HP:0002475)1.53895120
163Premature skin wrinkling (HP:0100678)1.53650131
164Scapular winging (HP:0003691)1.53409520
165Abnormal ossification of hand bones (HP:0005921)1.53370714
166Patent foramen ovale (HP:0001655)1.52635788
167Broad finger (HP:0001500)1.52472227
168Keratoconus (HP:0000563)1.52467823
169Increased corneal curvature (HP:0100692)1.52467823
170Abnormality of the wing of the ilium (HP:0011867)1.51719053
171Optic nerve coloboma (HP:0000588)1.51595931
172Increased number of teeth (HP:0011069)1.50715124
173Abnormality of skull ossification (HP:0002703)1.49987777
174Abnormal vertebral ossification (HP:0100569)1.49437425
175Smooth philtrum (HP:0000319)1.49396192
176Broad phalanges of the hand (HP:0009768)1.48841616
177Flat cornea (HP:0007720)1.48691972
178Slender long bone (HP:0003100)1.48488638
179Partial duplication of the phalanx of hand (HP:0009999)1.48290087
180Prolonged bleeding time (HP:0003010)1.47902075
181Atresia of the external auditory canal (HP:0000413)1.47723201
182Mitral regurgitation (HP:0001653)1.47594561
183Absent eyelashes (HP:0000561)1.47460386
184Biconcave vertebral bodies (HP:0004586)1.46587792
185Milia (HP:0001056)1.45877353

Predicted kinase interactions (KEA)

RankGene SetZ-score
1MST1R5.98178816
2MKNK13.88571839
3MKNK23.54316221
4VRK23.27358412
5TIE13.09450240
6KIT3.07696325
7CDK82.83116932
8MET2.63754203
9EPHA22.47272981
10BRD42.23534851
11LATS22.21436278
12TAF12.10975264
13LATS12.01899301
14TGFBR12.01725290
15STK161.96726010
16MAPKAPK31.92906886
17SMG11.92838405
18EPHB21.92084369
19TRPM71.78353296
20IRAK31.77719780
21BMPR1B1.77303791
22MAP3K121.74907806
23STK31.68787972
24NLK1.67801673
25RIPK11.67101137
26CSF1R1.66408538
27TEC1.63098025
28MUSK1.61321147
29CDK71.56004284
30NME21.54625459
31ICK1.52804703
32DYRK31.49106951
33MAP3K31.48763859
34EIF2AK21.47504165
35PAK41.46846995
36EIF2AK11.46207786
37BTK1.44183496
38FLT31.43815959
39CLK11.34978965
40MYLK1.34487930
41NEK91.33823733
42MATK1.31106061
43EPHA31.30785205
44ERBB31.27812146
45RPS6KA41.18523452
46SIK11.17201414
47YES11.15833056
48DDR21.14693167
49CDK121.10168552
50PAK21.09330334
51CSNK1G11.08853292
52TGFBR21.05352803
53TTN1.02101803
54CDK31.00403846
55BRSK20.98869515
56MELK0.96786596
57PRKG20.96547516
58ATR0.95929720
59EEF2K0.94503816
60PBK0.93700110
61EIF2AK30.93189436
62STK38L0.92785331
63FRK0.89172890
64MAPK110.88584517
65MAP4K10.87854042
66CDK60.86625955
67MAP3K100.86490843
68PASK0.85528937
69OBSCN0.85228619
70MAP2K30.84169548
71ERN10.82908790
72PIM20.81497379
73RPS6KB20.80361020
74ABL20.79140762
75IKBKB0.76931967
76CSNK1A1L0.76784721
77NEK20.76400723
78FGFR10.75299832
79TLK10.74869352
80BMX0.74140728
81PTK60.73377103
82MTOR0.72193699
83PIK3CG0.71046746
84VRK10.70738318
85NUAK10.69755410
86CDK40.68876051
87DAPK10.68525120
88FER0.67954115
89NME10.67640404
90WEE10.67375303
91TXK0.67328634
92PNCK0.67052187
93LRRK20.66931309
94LMTK20.65719654
95PIM10.65505949
96DYRK1B0.65479286
97PINK10.63148034
98CSNK1G30.62667112
99PTK2B0.62307278
100ACVR1B0.61011586
101FGFR20.60471863
102FGFR30.58660776
103MAPK40.58346781
104PRKAA20.56885905
105MAP2K60.56501693
106SGK20.56346186
107ADRBK10.55807518
108SIK30.54048799
109TTK0.53607084
110TRIM280.53116359
111MAPKAPK50.52620469
112IRAK40.51755393
113MAPKAPK20.51497624
114SRPK10.50334215
115PHKG10.50025543
116PHKG20.50025543
117GSK3A0.49882181
118ILK0.49510422
119AKT20.49437700
120AKT30.49422843
121AURKB0.49071553
122CHEK20.47472549
123CHEK10.47145910
124CDC70.46585477
125AURKA0.46574538
126IGF1R0.46347647
127STK100.45897862
128TRIB30.45677320
129PIK3CA0.44623095
130PRKD20.44353644
131MAP2K10.44264563
132GRK10.44181292
133TNIK0.43613380
134PLK30.42709441
135MAP2K20.41241244
136CCNB10.40825317
137PRKAA10.40623247
138PTK20.40540999
139PDGFRA0.39480705
140EPHB10.39285456
141MAPK70.39272643
142SGK30.39258068
143PLK10.39121916
144AKT10.38690394
145CDK90.38687712
146TNK20.38657750
147MAP3K70.38593206
148CHUK0.38449225
149BRSK10.37706041
150RPS6KA60.37115710
151CAMK1G0.37111236
152MAPK10.36952739
153INSRR0.36341277
154ZAK0.35740031
155RPS6KB10.35347684
156BCKDK0.34121726
157GRK50.33744694

Predicted pathways (KEGG)

RankGene SetZ-score
1Sulfur relay system_Homo sapiens_hsa041223.15861670
2Ribosome_Homo sapiens_hsa030103.15035229
3DNA replication_Homo sapiens_hsa030302.77384822
4Base excision repair_Homo sapiens_hsa034102.32773327
5Pentose and glucuronate interconversions_Homo sapiens_hsa000402.27858439
6Cell cycle_Homo sapiens_hsa041102.25712699
7Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006012.20906291
8Sulfur metabolism_Homo sapiens_hsa009202.14673751
9Maturity onset diabetes of the young_Homo sapiens_hsa049502.09235959
10ECM-receptor interaction_Homo sapiens_hsa045122.04282405
11Transcriptional misregulation in cancer_Homo sapiens_hsa052022.01979366
12Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005632.01959307
13Basal cell carcinoma_Homo sapiens_hsa052171.99928143
14Spliceosome_Homo sapiens_hsa030401.99718184
15Homologous recombination_Homo sapiens_hsa034401.87803943
16Galactose metabolism_Homo sapiens_hsa000521.84583626
17Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005331.81839282
18Pentose phosphate pathway_Homo sapiens_hsa000301.75025824
19Drug metabolism - other enzymes_Homo sapiens_hsa009831.68882180
20Mismatch repair_Homo sapiens_hsa034301.65347957
21Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001301.62558510
22Nitrogen metabolism_Homo sapiens_hsa009101.62087665
23Chemical carcinogenesis_Homo sapiens_hsa052041.61088563
24Small cell lung cancer_Homo sapiens_hsa052221.56909427
25Bacterial invasion of epithelial cells_Homo sapiens_hsa051001.56733548
26Ascorbate and aldarate metabolism_Homo sapiens_hsa000531.56703759
27Basal transcription factors_Homo sapiens_hsa030221.56274515
28p53 signaling pathway_Homo sapiens_hsa041151.48424292
29Glycerolipid metabolism_Homo sapiens_hsa005611.45365263
30RNA degradation_Homo sapiens_hsa030181.44606130
31Fanconi anemia pathway_Homo sapiens_hsa034601.44497733
32Drug metabolism - cytochrome P450_Homo sapiens_hsa009821.44147025
33Steroid hormone biosynthesis_Homo sapiens_hsa001401.43489055
34Glutathione metabolism_Homo sapiens_hsa004801.43175287
35Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate_Homo sapiens_hsa005321.42171415
36Non-homologous end-joining_Homo sapiens_hsa034501.41400256
37MicroRNAs in cancer_Homo sapiens_hsa052061.40149874
38Cysteine and methionine metabolism_Homo sapiens_hsa002701.37837219
39Bladder cancer_Homo sapiens_hsa052191.35639161
40Caffeine metabolism_Homo sapiens_hsa002321.34336714
41Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009801.33937841
42Notch signaling pathway_Homo sapiens_hsa043301.31450246
43Focal adhesion_Homo sapiens_hsa045101.30812730
44Selenocompound metabolism_Homo sapiens_hsa004501.30373904
45PI3K-Akt signaling pathway_Homo sapiens_hsa041511.30022804
46Proteoglycans in cancer_Homo sapiens_hsa052051.29833560
47Hippo signaling pathway_Homo sapiens_hsa043901.29545534
48Arginine and proline metabolism_Homo sapiens_hsa003301.29306087
49N-Glycan biosynthesis_Homo sapiens_hsa005101.28208106
50Proteasome_Homo sapiens_hsa030501.27413232
51Pathways in cancer_Homo sapiens_hsa052001.26838044
52Starch and sucrose metabolism_Homo sapiens_hsa005001.26813850
53Nucleotide excision repair_Homo sapiens_hsa034201.26288955
54Chronic myeloid leukemia_Homo sapiens_hsa052201.25517803
55Other types of O-glycan biosynthesis_Homo sapiens_hsa005141.23730112
56RNA polymerase_Homo sapiens_hsa030201.22480473
57Prostate cancer_Homo sapiens_hsa052151.22127814
58Vitamin digestion and absorption_Homo sapiens_hsa049771.21736430
592-Oxocarboxylic acid metabolism_Homo sapiens_hsa012101.21664401
60Fructose and mannose metabolism_Homo sapiens_hsa000511.20887100
61Herpes simplex infection_Homo sapiens_hsa051681.19933951
62Protein digestion and absorption_Homo sapiens_hsa049741.19595811
63TGF-beta signaling pathway_Homo sapiens_hsa043501.18839648
64Platelet activation_Homo sapiens_hsa046111.18534427
65Fat digestion and absorption_Homo sapiens_hsa049751.18336866
66Adherens junction_Homo sapiens_hsa045201.14980982
67Pathogenic Escherichia coli infection_Homo sapiens_hsa051301.14598969
68Acute myeloid leukemia_Homo sapiens_hsa052211.14044220
69Thyroid cancer_Homo sapiens_hsa052161.12365835
70HTLV-I infection_Homo sapiens_hsa051661.12254585
71Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa045501.10339075
72Hedgehog signaling pathway_Homo sapiens_hsa043401.10177040
73Melanoma_Homo sapiens_hsa052181.09648286
74Renin-angiotensin system_Homo sapiens_hsa046141.09641223
75Pyrimidine metabolism_Homo sapiens_hsa002401.09342671
76One carbon pool by folate_Homo sapiens_hsa006701.09245853
77Other glycan degradation_Homo sapiens_hsa005111.06714238
78Viral myocarditis_Homo sapiens_hsa054161.06317195
79Cytosolic DNA-sensing pathway_Homo sapiens_hsa046231.05604145
80Sphingolipid metabolism_Homo sapiens_hsa006001.01461145
81RNA transport_Homo sapiens_hsa030131.01137269
82Lysine degradation_Homo sapiens_hsa003101.00007164
83AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa049330.98109374
84Circadian rhythm_Homo sapiens_hsa047100.94961791
85Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030080.94322139
86Jak-STAT signaling pathway_Homo sapiens_hsa046300.93761343
87Wnt signaling pathway_Homo sapiens_hsa043100.92839650
88Shigellosis_Homo sapiens_hsa051310.92002915
89Arginine biosynthesis_Homo sapiens_hsa002200.91948765
90mRNA surveillance pathway_Homo sapiens_hsa030150.91758666
91NF-kappa B signaling pathway_Homo sapiens_hsa040640.90718835
92Rap1 signaling pathway_Homo sapiens_hsa040150.90127663
93Cyanoamino acid metabolism_Homo sapiens_hsa004600.87330580
94Measles_Homo sapiens_hsa051620.86041191
95Hepatitis B_Homo sapiens_hsa051610.85668312
96Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa005200.85000350
97Cytokine-cytokine receptor interaction_Homo sapiens_hsa040600.84931152
98Hematopoietic cell lineage_Homo sapiens_hsa046400.84288116
99Folate biosynthesis_Homo sapiens_hsa007900.83367740
100Longevity regulating pathway - mammal_Homo sapiens_hsa042110.83322671
101Arrhythmogenic right ventricular cardiomyopathy (ARVC)_Homo sapiens_hsa054120.81800486
102Peroxisome_Homo sapiens_hsa041460.80146217
103SNARE interactions in vesicular transport_Homo sapiens_hsa041300.78088754
104Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005120.76690519
105Intestinal immune network for IgA production_Homo sapiens_hsa046720.76110772
106Malaria_Homo sapiens_hsa051440.75634550
107Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007600.75529508
108Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008600.75456498
109Pantothenate and CoA biosynthesis_Homo sapiens_hsa007700.73789969
110Regulation of actin cytoskeleton_Homo sapiens_hsa048100.72851250
111Phenylalanine metabolism_Homo sapiens_hsa003600.72273591
112Toxoplasmosis_Homo sapiens_hsa051450.70837656
113Hypertrophic cardiomyopathy (HCM)_Homo sapiens_hsa054100.69272046
114Metabolic pathways_Homo sapiens_hsa011000.69167681
115Leukocyte transendothelial migration_Homo sapiens_hsa046700.69131411
116Melanogenesis_Homo sapiens_hsa049160.68291999
117Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006300.67092385
118Ubiquitin mediated proteolysis_Homo sapiens_hsa041200.66768172
119Glycolysis / Gluconeogenesis_Homo sapiens_hsa000100.66557155
120TNF signaling pathway_Homo sapiens_hsa046680.66266991
121Purine metabolism_Homo sapiens_hsa002300.66050773
122Leishmaniasis_Homo sapiens_hsa051400.65072621
123Viral carcinogenesis_Homo sapiens_hsa052030.64726233
124Tyrosine metabolism_Homo sapiens_hsa003500.64637363
125Complement and coagulation cascades_Homo sapiens_hsa046100.64527554
126Propanoate metabolism_Homo sapiens_hsa006400.63876058
127Histidine metabolism_Homo sapiens_hsa003400.62960454
128Toll-like receptor signaling pathway_Homo sapiens_hsa046200.61840861
129FoxO signaling pathway_Homo sapiens_hsa040680.60598895
130Ether lipid metabolism_Homo sapiens_hsa005650.60091798
131Longevity regulating pathway - multiple species_Homo sapiens_hsa042130.59074994
132Inflammatory bowel disease (IBD)_Homo sapiens_hsa053210.58769862
133Arachidonic acid metabolism_Homo sapiens_hsa005900.58745656
134Glycerophospholipid metabolism_Homo sapiens_hsa005640.57458288
135Non-small cell lung cancer_Homo sapiens_hsa052230.56804029
136AMPK signaling pathway_Homo sapiens_hsa041520.55900066
137Epstein-Barr virus infection_Homo sapiens_hsa051690.55894450
138Tryptophan metabolism_Homo sapiens_hsa003800.55683018
139Axon guidance_Homo sapiens_hsa043600.55576054
140Pancreatic cancer_Homo sapiens_hsa052120.55013218
141Salmonella infection_Homo sapiens_hsa051320.53584698
142Colorectal cancer_Homo sapiens_hsa052100.53573990
143Apoptosis_Homo sapiens_hsa042100.52935364
144Pyruvate metabolism_Homo sapiens_hsa006200.52111191
145RIG-I-like receptor signaling pathway_Homo sapiens_hsa046220.51326958
146Amoebiasis_Homo sapiens_hsa051460.51068437
147Glycosaminoglycan degradation_Homo sapiens_hsa005310.51014197
148Regulation of lipolysis in adipocytes_Homo sapiens_hsa049230.46915717
149Fatty acid biosynthesis_Homo sapiens_hsa000610.46476842
150Retinol metabolism_Homo sapiens_hsa008300.46348900
151Ovarian steroidogenesis_Homo sapiens_hsa049130.46332776
152Dilated cardiomyopathy_Homo sapiens_hsa054140.45139600
153Glucagon signaling pathway_Homo sapiens_hsa049220.44302902
154Endometrial cancer_Homo sapiens_hsa052130.43947877
155Phototransduction_Homo sapiens_hsa047440.43488766
156Protein processing in endoplasmic reticulum_Homo sapiens_hsa041410.36687726
157African trypanosomiasis_Homo sapiens_hsa051430.35938732
158Insulin resistance_Homo sapiens_hsa049310.35472115
159Fatty acid degradation_Homo sapiens_hsa000710.34727978
160Glycine, serine and threonine metabolism_Homo sapiens_hsa002600.34622045
161Biosynthesis of amino acids_Homo sapiens_hsa012300.31386639

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