HOXA4

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: In vertebrates, the genes encoding the class of transcription factors called homeobox genes are found in clusters named A, B, C, and D on four separate chromosomes. Expression of these proteins is spatially and temporally regulated during embryonic development. This gene is part of the A cluster on chromosome 7 and encodes a DNA-binding transcription factor which may regulate gene expression, morphogenesis, and differentiation. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1cilium or flagellum-dependent cell motility (GO:0001539)8.93639887
2fusion of sperm to egg plasma membrane (GO:0007342)8.75420038
3sperm motility (GO:0030317)8.30797142
4regulation of cilium movement (GO:0003352)7.72597048
5sperm-egg recognition (GO:0035036)7.13668099
6acrosome assembly (GO:0001675)7.13557055
7acrosome reaction (GO:0007340)6.92772000
8multicellular organism reproduction (GO:0032504)6.88231093
9cell wall macromolecule catabolic process (GO:0016998)6.74692441
10cell wall macromolecule metabolic process (GO:0044036)6.74692441
11binding of sperm to zona pellucida (GO:0007339)6.70881394
12plasma membrane fusion (GO:0045026)6.63752708
13motile cilium assembly (GO:0044458)6.43254124
14cell-cell recognition (GO:0009988)6.34785454
15polyketide metabolic process (GO:0030638)6.25914656
16doxorubicin metabolic process (GO:0044598)6.25914656
17daunorubicin metabolic process (GO:0044597)6.25914656
18thyroid gland development (GO:0030878)6.21647877
19epithelial cilium movement (GO:0003351)6.21352106
20axonemal dynein complex assembly (GO:0070286)6.14566172
21spermatid development (GO:0007286)6.06889038
22reproduction (GO:0000003)5.86026050
23cranial nerve morphogenesis (GO:0021602)5.71500827
24piRNA metabolic process (GO:0034587)5.53347435
25muscle cell fate commitment (GO:0042693)5.46773962
26single fertilization (GO:0007338)5.42130721
27regulation of response to osmotic stress (GO:0047484)5.33999721
28microtubule severing (GO:0051013)5.31095708
29lymph vessel development (GO:0001945)5.30743343
30cilium movement (GO:0003341)5.21390031
31ventricular system development (GO:0021591)5.11070507
32heterochromatin organization (GO:0070828)5.08699900
33synaptonemal complex organization (GO:0070193)4.88626657
34synaptonemal complex assembly (GO:0007130)4.84044026
35sperm capacitation (GO:0048240)4.73348401
36male meiosis (GO:0007140)4.73149078
37organic cation transport (GO:0015695)4.67057542
38protein polyglutamylation (GO:0018095)4.60529775
39regulation of microtubule-based movement (GO:0060632)4.58646218
40epithelial cilium movement involved in determination of left/right asymmetry (GO:0060287)4.55928800
41fertilization (GO:0009566)4.54554551
42negative regulation of epidermis development (GO:0045683)4.45676100
43chromosome condensation (GO:0030261)4.43629092
44outer ear morphogenesis (GO:0042473)4.15229382
45embryonic viscerocranium morphogenesis (GO:0048703)4.13079421
46muscle filament sliding (GO:0030049)4.10523240
47actin-myosin filament sliding (GO:0033275)4.10523240
48aminoglycoside antibiotic metabolic process (GO:0030647)4.09887550
49response to muscle activity (GO:0014850)4.09828698
50spermatogenesis (GO:0007283)4.09805489
51male gamete generation (GO:0048232)4.07932043
52outflow tract septum morphogenesis (GO:0003148)4.05175605
53* embryonic skeletal system morphogenesis (GO:0048704)4.03439263
54protein localization to chromosome, centromeric region (GO:0071459)3.97505494
55negative regulation of G2/M transition of mitotic cell cycle (GO:0010972)3.94433889
56regulation of apoptotic process involved in morphogenesis (GO:1902337)3.91688055
57DNA packaging (GO:0006323)3.91188501
58nuclear pore complex assembly (GO:0051292)3.89858187
59nephron tubule morphogenesis (GO:0072078)3.85679493
60nephron epithelium morphogenesis (GO:0072088)3.85679493
61genitalia morphogenesis (GO:0035112)3.82566383
62regulation of mammary gland epithelial cell proliferation (GO:0033599)3.81188274
63negative regulation of inclusion body assembly (GO:0090084)3.79883613
64regulation of nuclear cell cycle DNA replication (GO:0033262)3.77944415
65maintenance of protein location in nucleus (GO:0051457)3.77860405
66mitotic sister chromatid segregation (GO:0000070)3.75175452
67seminiferous tubule development (GO:0072520)3.75092799
68gamete generation (GO:0007276)3.74335966
69cochlea morphogenesis (GO:0090103)3.68491175
70DNA replication-dependent nucleosome organization (GO:0034723)3.67100079
71DNA replication-dependent nucleosome assembly (GO:0006335)3.67100079
72positive regulation of histone deacetylation (GO:0031065)3.63549851
73germ cell development (GO:0007281)3.56680105
74ribosomal small subunit biogenesis (GO:0042274)3.56658831
75mammary gland epithelial cell differentiation (GO:0060644)3.56269483
76chromatin assembly (GO:0031497)3.56147000
77negative regulation of cell size (GO:0045792)3.54896434
78microtubule depolymerization (GO:0007019)3.48207160
79respiratory system process (GO:0003016)3.47202325
80protein localization to kinetochore (GO:0034501)3.46155409
81negative regulation of cell cycle G2/M phase transition (GO:1902750)3.46050353
82cellular process involved in reproduction in multicellular organism (GO:0022412)3.43368975
83kidney mesenchyme development (GO:0072074)3.40971357
84skeletal muscle contraction (GO:0003009)3.39925463
85nucleoside transmembrane transport (GO:1901642)3.38800145
86respiratory tube development (GO:0030323)3.37957350
87negative regulation of intracellular estrogen receptor signaling pathway (GO:0033147)3.37903742
88sister chromatid segregation (GO:0000819)3.37862983
89actin-mediated cell contraction (GO:0070252)3.37507606
90positive regulation of protein deacetylation (GO:0090312)3.37078950
91positive regulation of myotube differentiation (GO:0010831)3.34352352
92chromosome organization involved in meiosis (GO:0070192)3.34213087
93negative regulation of epidermal cell differentiation (GO:0045605)3.33206240
94protein retention in ER lumen (GO:0006621)3.30126946
95negative regulation of erythrocyte differentiation (GO:0045647)3.26745648
96protein localization to cilium (GO:0061512)3.24912992
97meiotic cell cycle (GO:0051321)3.23660197
98DNA methylation involved in gamete generation (GO:0043046)3.21727015
99negative regulation of homotypic cell-cell adhesion (GO:0034111)3.19213974
100myofibril assembly (GO:0030239)3.16399099
101mesenchymal-epithelial cell signaling (GO:0060638)3.15940355
102male meiosis I (GO:0007141)3.14969338
103tachykinin receptor signaling pathway (GO:0007217)3.14893297
104* skeletal system morphogenesis (GO:0048705)3.12929705
105embryonic heart tube development (GO:0035050)3.12747639
106left/right pattern formation (GO:0060972)3.10760097
107regulation of inclusion body assembly (GO:0090083)3.09452425
108body morphogenesis (GO:0010171)3.08210095
109maintenance of protein localization in endoplasmic reticulum (GO:0035437)3.05850602
110nuclear pore organization (GO:0006999)3.05677161
111tooth mineralization (GO:0034505)3.05621077
112cell-substrate adherens junction assembly (GO:0007045)3.05454447
113focal adhesion assembly (GO:0048041)3.05454447
114heart trabecula formation (GO:0060347)3.05281653
115RNA stabilization (GO:0043489)3.02571877
116mRNA stabilization (GO:0048255)3.02571877
117muscle organ morphogenesis (GO:0048644)3.01841505
118meiotic nuclear division (GO:0007126)3.01062450
119formation of translation preinitiation complex (GO:0001731)2.97511168
120hormone catabolic process (GO:0042447)2.96064091
121multicellular organismal reproductive process (GO:0048609)2.95556840
122peripheral nervous system neuron development (GO:0048935)2.95060993
123embryonic skeletal joint morphogenesis (GO:0060272)2.94700156
124cell recognition (GO:0008037)2.93461938
125* embryonic organ morphogenesis (GO:0048562)2.93088231
126regulation of cardioblast differentiation (GO:0051890)2.92957352
127spermatid nucleus differentiation (GO:0007289)2.91362074
128DNA damage response, detection of DNA damage (GO:0042769)2.90237997
129adherens junction assembly (GO:0034333)2.89871522
130coronary vasculature morphogenesis (GO:0060977)2.89594550
131transepithelial transport (GO:0070633)2.88856123
132response to parathyroid hormone (GO:0071107)2.88818477
133regulation of skeletal muscle contraction (GO:0014819)2.88482531
134positive regulation of DNA-dependent DNA replication (GO:2000105)2.86844663
135skeletal muscle fiber development (GO:0048741)2.85097353
136* multicellular organismal development (GO:0007275)2.84416038
137notochord development (GO:0030903)2.84010828
138histone H4-K8 acetylation (GO:0043982)2.83435625
139histone H4-K5 acetylation (GO:0043981)2.83435625
140cell proliferation involved in metanephros development (GO:0072203)2.83375312
141pore complex assembly (GO:0046931)2.82529866
142sarcoplasmic reticulum calcium ion transport (GO:0070296)2.81483848
143AMP metabolic process (GO:0046033)2.81324338
144regulation of telomere maintenance via telomerase (GO:0032210)2.81147153
145regulation of heart morphogenesis (GO:2000826)2.79364416
146positive regulation of smoothened signaling pathway (GO:0045880)2.79093918
147glycolytic process (GO:0006096)2.78794331
148response to stimulus involved in regulation of muscle adaptation (GO:0014874)2.78682806
149middle ear morphogenesis (GO:0042474)2.78008421
150negative regulation of organelle assembly (GO:1902116)2.77882384
151sarcomere organization (GO:0045214)2.76935258
152negative regulation of endoplasmic reticulum calcium ion concentration (GO:0032471)2.76097502
153* anterior/posterior pattern specification (GO:0009952)2.74867847
154negative regulation of necroptotic process (GO:0060546)2.72947272
155peptidyl-lysine dimethylation (GO:0018027)2.69373778
156regulation of NFAT protein import into nucleus (GO:0051532)2.68602781
157negative regulation of retinoic acid receptor signaling pathway (GO:0048387)2.67915602
158regulation of early endosome to late endosome transport (GO:2000641)2.65121736
159cardiac muscle cell proliferation (GO:0060038)2.62209128
160creatine metabolic process (GO:0006600)2.61050901
161regulation of secondary heart field cardioblast proliferation (GO:0003266)2.60820948
162regulation of cardioblast proliferation (GO:0003264)2.60820948
163proximal/distal pattern formation (GO:0009954)2.59088565
164muscle cell cellular homeostasis (GO:0046716)2.58112429
165glycogen catabolic process (GO:0005980)2.57939658
166cardiac myofibril assembly (GO:0055003)2.53893107
167rRNA transcription (GO:0009303)2.51528745
168trabecula formation (GO:0060343)2.50608932
169mitotic chromosome condensation (GO:0007076)2.50601670
170vascular endothelial growth factor receptor signaling pathway (GO:0048010)2.50479986
171protein maturation by protein folding (GO:0022417)2.48877958
172cartilage development involved in endochondral bone morphogenesis (GO:0060351)2.46925136
173proline biosynthetic process (GO:0006561)2.46577615
174oxidative phosphorylation (GO:0006119)2.46187008
175nucleotide salvage (GO:0043173)2.46076166
176glucan biosynthetic process (GO:0009250)2.45641961
177glycogen biosynthetic process (GO:0005978)2.45641961
178regulation of myotube differentiation (GO:0010830)2.45041628
179apoptotic process involved in morphogenesis (GO:0060561)2.44078823
180regulation of mesenchymal cell apoptotic process (GO:2001053)2.39456417
181grooming behavior (GO:0007625)2.37231682
182osteoblast development (GO:0002076)2.36899983
183glycogen metabolic process (GO:0005977)2.35375567
184negative regulation of fatty acid transport (GO:2000192)2.34274433
185cell-substrate junction assembly (GO:0007044)2.33790175
186glucan catabolic process (GO:0009251)2.33136817
187ribonucleoprotein complex biogenesis (GO:0022613)2.32544568
188gluconeogenesis (GO:0006094)2.31425062
189RNA localization (GO:0006403)2.30004401
190ribosome biogenesis (GO:0042254)2.29929850
191organ induction (GO:0001759)2.29912234
192cartilage morphogenesis (GO:0060536)2.29056159
1934-hydroxyproline metabolic process (GO:0019471)2.28710332
194glucan metabolic process (GO:0044042)2.27897402
195cellular glucan metabolic process (GO:0006073)2.27897402

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1MYBL1_21750041_ChIP-ChIP_SPERMATOCYTES_Mouse9.18835573
2BP1_19119308_ChIP-ChIP_Hs578T_Human4.97319329
3KLF4_18264089_ChIP-ChIP_MESCs_Mouse4.93494038
4KLF2_18264089_ChIP-ChIP_MESCs_Mouse4.93494038
5KLF5_18264089_ChIP-ChIP_MESCs_Mouse4.93494038
6STAT6_21828071_ChIP-Seq_BEAS2B_Human3.21933172
7NOTCH1_17114293_ChIP-ChIP_T-ALL_Human2.93220589
8ZNF263_19887448_ChIP-Seq_K562_Human2.88550331
9TP63_19390658_ChIP-ChIP_HaCaT_Human2.78161512
10RARG_19884340_ChIP-ChIP_MEFs_Mouse2.70087709
11ESR1_15608294_ChIP-ChIP_MCF-7_Human2.60700205
12MYC_18555785_ChIP-Seq_MESCs_Mouse2.59340838
13NACC1_18358816_ChIP-ChIP_MESCs_Mouse2.56805230
14RUNX1_26923725_Chip-Seq_MACROPHAGESS_Mouse2.53688254
15GLI1_17442700_ChIP-ChIP_MESCs_Mouse2.49544723
16FOXM1_23109430_ChIP-Seq_U2OS_Human2.49339899
17ZFP322A_24550733_ChIP-Seq_MESCs_Mouse2.42338183
18* PPARG_19300518_ChIP-PET_3T3-L1_Mouse2.33783503
19* CHD7_19251738_ChIP-ChIP_MESCs_Mouse2.31270751
20HCFC1_20581084_ChIP-Seq_MESCs_Mouse2.31087709
21EKLF_21900194_ChIP-Seq_ERYTHROCYTE_Mouse2.28638455
22SMAD1_18555785_ChIP-Seq_MESCs_Mouse2.25626007
23* ELK3_25401928_ChIP-Seq_HUVEC_Human2.21904842
24GATA1_26923725_Chip-Seq_HPCs_Mouse2.21200883
25PRDM16_22522345_ChIP-ChIP_PALATE_MESENCHYMAL_Mouse2.17542289
26TAF7L_23326641_ChIP-Seq_C3H10T1-2_Mouse2.14561921
27E2F7_22180533_ChIP-Seq_HELA_Human2.12619483
28TP63_17297297_ChIP-ChIP_HaCaT_Human2.11375453
29LXR_22292898_ChIP-Seq_THP-1_Human2.04478327
30DACH1_20351289_ChIP-Seq_MDA-MB-231_Human2.01600962
31RACK7_27058665_Chip-Seq_MCF-7_Human1.95257053
32ESR1_17901129_ChIP-ChIP_LIVER_Mouse1.95152995
33THRA_23701648_ChIP-Seq_CEREBELLUM_Mouse1.87237441
34VDR_21846776_ChIP-Seq_THP-1_Human1.87014284
35* TP53_20018659_ChIP-ChIP_R1E_Mouse1.84173723
36XRN2_22483619_ChIP-Seq_HELA_Human1.82880669
37KDM2B_26808549_Chip-Seq_SIL-ALL_Human1.78351070
38TRIM28_21343339_ChIP-Seq_HEK293_Human1.78191277
39ZFX_18555785_ChIP-Seq_MESCs_Mouse1.74641776
40TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat1.72784131
41ZNF652_21678463_ChIP-ChIP_ZR75-1_Human1.70093830
42MYC_22102868_ChIP-Seq_BL_Human1.66025777
43ELK4_26923725_Chip-Seq_MESODERM_Mouse1.65840019
44NUCKS1_24931609_ChIP-Seq_HEPATOCYTES_Mouse1.65262474
45E2F1_17053090_ChIP-ChIP_MCF-7_Human1.61162777
46KLF6_26769127_Chip-Seq_PDAC-Cell_line_Human1.58836222
47MYC_18358816_ChIP-ChIP_MESCs_Mouse1.58751621
48* TP53_22127205_ChIP-Seq_IMR90_Human1.57770082
49THAP11_20581084_ChIP-Seq_MESCs_Mouse1.55059287
50CREM_20920259_ChIP-Seq_GC1-SPG_Mouse1.54327490
51KLF4_18358816_ChIP-ChIP_MESCs_Mouse1.51900489
52CLOCK_20551151_ChIP-Seq_293T_Human1.51410779
53* PHC1_16625203_ChIP-ChIP_MESCs_Mouse1.51325813
54CREB1_23762244_ChIP-Seq_HIPPOCAMPUS_Rat1.50866943
55NANOG_18700969_ChIP-ChIP_MESCs_Mouse1.50029135
56KDM2B_26808549_Chip-Seq_SUP-B15_Human1.49678834
57ELF1_20517297_ChIP-Seq_JURKAT_Human1.48464137
58EZH2_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse1.48441491
59* YY1_22570637_ChIP-Seq_MALME-3M_Human1.48249895
60TCF3_18692474_ChIP-Seq_MESCs_Mouse1.47515731
61UBF1/2_26484160_Chip-Seq_HMEC-DERIVED_Human1.46133189
62PRDM14_21183938_ChIP-Seq_MESCs_Mouse1.45449863
63TBP_23326641_ChIP-Seq_C3H10T1-2_Mouse1.44445573
64IRF1_19129219_ChIP-ChIP_H3396_Human1.44267786
65KDM2B_26808549_Chip-Seq_K562_Human1.43901074
66CTCF_27219007_Chip-Seq_ERYTHROID_Human1.42908275
67SOX2_18358816_ChIP-ChIP_MESCs_Mouse1.39965965
68ATF3_27146783_Chip-Seq_COLON_Human1.39808218
69VDR_22108803_ChIP-Seq_LS180_Human1.39756134
70CCND1_20090754_ChIP-ChIP_RETINA_Mouse1.38456831
71FOXM1_25889361_ChIP-Seq_OE33_AND_U2OS_Human1.38376950
72SMAD3_22036565_ChIP-Seq_ESCs_Mouse1.38353660
73RNF2_27304074_Chip-Seq_NSC_Mouse1.37814595
74KDM2B_26808549_Chip-Seq_DND41_Human1.37533749
75SETDB1_19884257_ChIP-Seq_MESCs_Mouse1.37239010
76MYC_19079543_ChIP-ChIP_MESCs_Mouse1.36353101
77STAT3_19079543_ChIP-ChIP_MESCs_Mouse1.36222156
78KLF4_26769127_Chip-Seq_PDAC-Cell_line_Human1.35391264
79* UBF1/2_26484160_Chip-Seq_HMECs_Human1.33468580
80E2F4_17652178_ChIP-ChIP_JURKAT_Human1.33341501
81TTF2_22483619_ChIP-Seq_HELA_Human1.33051608
82P300_27058665_Chip-Seq_ZR-75-30cells_Human1.31694008
83AR_21909140_ChIP-Seq_LNCAP_Human1.31049820
84CREB1_26743006_Chip-Seq_LNCaP-abl_Human1.28822579
85EZH2_18974828_ChIP-Seq_MESCs_Mouse1.27676295
86RNF2_18974828_ChIP-Seq_MESCs_Mouse1.27676295
87STAT3_1855785_ChIP-Seq_MESCs_Mouse1.27269324
88TCF3_18347094_ChIP-ChIP_MESCs_Mouse1.26756747
89ZFP281_18358816_ChIP-ChIP_MESCs_Mouse1.24293217
90FLI1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.24027015
91NANOG_18347094_ChIP-ChIP_MESCs_Mouse1.23661192
92MYCN_27167114_Chip-Seq_NEUROBLASTOMA_Human1.23455799
93PPARG_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse1.22963049
94TCFAP2C_20176728_ChIP-ChIP_TROPHOBLAST_STEM_CELLS_Mouse1.22797585
95NFIB_24661679_ChIP-Seq_LUNG_Mouse1.22282467
96CREB1_20920259_ChIP-Seq_GC1-SPG_Mouse1.21848720
97SA1_27219007_Chip-Seq_ERYTHROID_Human1.21491042
98* WT1_20215353_ChIP-ChIP_NEPHRON_PROGENITOR_Mouse1.21400738
99POU5F1_18700969_ChIP-ChIP_MESCs_Mouse1.21360608
100JARID1A_20064375_ChIP-Seq_MESCs_Mouse1.20539510
101DCP1A_22483619_ChIP-Seq_HELA_Human1.20305906
102ESR1_20079471_ChIP-ChIP_T-47D_Human1.19863420
103MYC_19030024_ChIP-ChIP_MESCs_Mouse1.19294814
104SMC4_20622854_ChIP-Seq_HELA_Human1.18457883
105NKX2-5_21415370_ChIP-Seq_HL-1_Mouse1.18420804
106CNOT3_19339689_ChIP-ChIP_MESCs_Mouse1.16750393
107HIF1A_21447827_ChIP-Seq_MCF-7_Human1.16268869
108SREBP1_19666523_ChIP-Seq_LIVER_Mouse1.16157784
109* CBX2_27304074_Chip-Seq_ESCs_Mouse1.15929090
110EGR1_20690147_ChIP-Seq_ERYTHROLEUKEMIA_Human1.14735006
111BCL3_23251550_ChIP-Seq_MUSCLE_Mouse1.14432329
112EGR1_19374776_ChIP-ChIP_THP-1_Human1.14368642
113SREBP2_21459322_ChIP-Seq_LIVER_Mouse1.14067430
114KLF4_18555785_ChIP-Seq_MESCs_Mouse1.13903834
115CEBPB_26923725_Chip-Seq_MACROPHAGESS_Mouse1.13223155
116PRDM5_23873026_ChIP-Seq_MEFs_Mouse1.13153246
117* EED_16625203_ChIP-ChIP_MESCs_Mouse1.12937346
118CTCF_21964334_Chip-Seq_Bcells_Human1.12593800
119SRY_22984422_ChIP-ChIP_TESTIS_Rat1.12200036
120TCF3_18467660_ChIP-ChIP_MESCs_Mouse1.11769217
121KDM2B_26808549_Chip-Seq_HPB-ALL_Human1.11641146
122NANOG_18358816_ChIP-ChIP_MESCs_Mouse1.10773429
123EWS-FLI1_20517297_ChIP-Seq_SK-N-MC_Human1.10582339
124TFAP2A_17053090_ChIP-ChIP_MCF-7_Human1.10509091
125TRP63_18441228_ChIP-ChIP_KERATINOCYTES_Mouse1.10110098
126CTCF_18555785_ChIP-Seq_MESCs_Mouse1.09973643
127TRIM28_19339689_ChIP-ChIP_MESCs_Mouse1.09761576
128* JARID2_20075857_ChIP-Seq_MESCs_Mouse1.09263184
129CSB_26484114_Chip-Seq_FIBROBLAST_Human1.08496227
130STAT3_18555785_ChIP-Seq_MESCs_Mouse1.08183994
131CREB1_26743006_Chip-Seq_LNCaP_Human1.07347949
132CEBPB_24764292_ChIP-Seq_MC3T3_Mouse1.06965173
133SPI1_26923725_Chip-Seq_HPCs_Mouse1.06690032
134MEIS1_26923725_Chip-Seq_HEMOGENIC-ENDOTHELIUM_Mouse1.06362802
135ZFP281_27345836_Chip-Seq_ESCs_Mouse1.06207128
136CDX2_19796622_ChIP-Seq_MESCs_Mouse1.05506353
137* ESET_19884257_ChIP-Seq_ESCs_Mouse1.05374796
138* TET1_21451524_ChIP-Seq_MESCs_Mouse1.05351858
139* KLF4_19030024_ChIP-ChIP_MESCs_Mouse1.05304786
140* EZH2_27304074_Chip-Seq_ESCs_Mouse1.03787672
141POU5F1_18692474_ChIP-Seq_MESCs_Mouse1.03699089
142* CDX2_20551321_ChIP-Seq_CACO-2_Human1.03533649
143SPI1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.03458752
144NR0B1_18358816_ChIP-ChIP_MESCs_Mouse1.03077263
145NANOG_18692474_ChIP-Seq_MESCs_Mouse1.02972714
146KLF4_25985364_ChIP-Seq_ATHEROSCLEROSIS_LESION_Mouse1.02206718
147MYC_27129775_Chip-Seq_CORNEA_Mouse1.01609418
148SOX3_22085726_ChIP-Seq_NPCs_Mouse1.01550558
149POU5F1_16518401_ChIP-PET_MESCs_Mouse1.00265262
150NANOG_18692474_ChIP-Seq_MEFs_Mouse0.99100886
151SPI1_20517297_ChIP-Seq_HL60_Human0.98920195
152SOX2_18555785_ChIP-Seq_MESCs_Mouse0.98700054
153RUNX2_24764292_ChIP-Seq_MC3T3_Mouse0.98542821
154TP63_22573176_ChIP-Seq_HFKS_Human0.98221064
155PHF8_20622854_ChIP-Seq_HELA_Human0.98124438
156* PBX_27287812_Chip-Seq_EMBYONIC-LIMB_Mouse0.98080348
157TAL1_26923725_Chip-Seq_HEMANGIOBLAST_Mouse0.97703471
158POU5F1_18358816_ChIP-ChIP_MESCs_Mouse0.94943938
159PPARG_20176806_ChIP-Seq_3T3-L1_Mouse0.94218651
160* BCOR_27268052_Chip-Seq_Bcells_Human0.93862796
161FLI1_26923725_Chip-Seq_HEMOGENIC-ENDOTHELIUM_Mouse0.93508645
162RXRA_24833708_ChIP-Seq_LIVER_Mouse0.93335119
163ZFP281_18757296_ChIP-ChIP_E14_Mouse0.93238380
164* EBNA1_20929547_Chip-Seq_RAJI-cells_Human0.92379315
165RARA_24833708_ChIP-Seq_LIVER_Mouse0.88258741
166TCF3_18692474_ChIP-Seq_MEFs_Mouse0.87413833
167FLI1_27457419_Chip-Seq_LIVER_Mouse0.86795144
168* GATA3_21867929_ChIP-Seq_CD8_Mouse0.86618061
169EZH2_22144423_ChIP-Seq_EOC_Human0.86156467
170CEBPB_26923725_Chip-Seq_HEMOGENIC-ENDOTHELIUM_Mouse0.83400730
171NCOR1_26117541_ChIP-Seq_K562_Human0.83272851
172P68_20966046_ChIP-Seq_HELA_Human0.83079393
173JARID1B-DAIN_22020125_ChIP-Seq_ESCs_Mouse0.80825695
174CTCF_26484167_Chip-Seq_Bcells_Mouse0.79994111
175SPI1_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse0.79984028
176CTCF_20526341_ChIP-Seq_ESCs_Human0.79730519
177TCF7_22412390_ChIP-Seq_EML_Mouse0.79511908
178ZFP42_18358816_ChIP-ChIP_MESCs_Mouse0.79084763
179SOX2_18692474_ChIP-Seq_MESCs_Mouse0.76827796
180SMC3_22415368_ChIP-Seq_MEFs_Mouse0.76712941
181SA1_22415368_ChIP-Seq_MEFs_Mouse0.75564607
182FOXP1_21924763_ChIP-Seq_HESCs_Human0.75262219

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0005410_abnormal_fertilization9.14169748
2MP0003011_delayed_dark_adaptation3.64502127
3MP0003123_paternal_imprinting3.33456624
4MP0003698_abnormal_male_reproductive3.25584080
5MP0001929_abnormal_gametogenesis2.91749628
6MP0003122_maternal_imprinting2.90352117
7MP0005623_abnormal_meninges_morphology2.85700978
8MP0002877_abnormal_melanocyte_morpholog2.75795674
9MP0004233_abnormal_muscle_weight2.56759265
10MP0003121_genomic_imprinting2.37542437
11MP0005451_abnormal_body_composition2.27874914
12MP0002249_abnormal_larynx_morphology2.25220685
13MP0003705_abnormal_hypodermis_morpholog2.19715000
14MP0004264_abnormal_extraembryonic_tissu2.15471679
15MP0004036_abnormal_muscle_relaxation2.14314046
16MP0000751_myopathy2.14240254
17MP0002653_abnormal_ependyma_morphology2.13498598
18MP0000681_abnormal_thyroid_gland2.11545870
19MP0004858_abnormal_nervous_system2.03658788
20MP0002234_abnormal_pharynx_morphology2.01969950
21MP0010030_abnormal_orbit_morphology1.96308934
22MP0008057_abnormal_DNA_replication1.96019451
23MP0004087_abnormal_muscle_fiber1.93142556
24MP0005075_abnormal_melanosome_morpholog1.86396117
25MP0002254_reproductive_system_inflammat1.85989529
26MP0002210_abnormal_sex_determination1.83502435
27MP0005330_cardiomyopathy1.80423091
28MP0001145_abnormal_male_reproductive1.79940226
29MP0008438_abnormal_cutaneous_collagen1.79536255
30MP0004782_abnormal_surfactant_physiolog1.77576014
31MP0003385_abnormal_body_wall1.77469559
32MP0002161_abnormal_fertility/fecundity1.77444243
33MP0000003_abnormal_adipose_tissue1.74943936
34MP0008961_abnormal_basal_metabolism1.72878077
35MP0003950_abnormal_plasma_membrane1.70440914
36MP0002269_muscular_atrophy1.67053819
37MP0001661_extended_life_span1.66259866
38MP0006292_abnormal_olfactory_placode1.61033496
39MP0005257_abnormal_intraocular_pressure1.60462398
40MP0000747_muscle_weakness1.58656778
41* MP0002932_abnormal_joint_morphology1.57440988
42MP0003279_aneurysm1.56743035
43MP0003942_abnormal_urinary_system1.56525059
44MP0001270_distended_abdomen1.56202665
45MP0005409_darkened_coat_color1.55425647
46MP0000749_muscle_degeneration1.53439211
47MP0000013_abnormal_adipose_tissue1.53408704
48MP0005670_abnormal_white_adipose1.52008253
49MP0005499_abnormal_olfactory_system1.50621289
50MP0005394_taste/olfaction_phenotype1.50621289
51MP0005369_muscle_phenotype1.47449969
52MP0003646_muscle_fatigue1.45070293
53MP0002332_abnormal_exercise_endurance1.41827298
54MP0003938_abnormal_ear_development1.41812196
55MP0001879_abnormal_lymphatic_vessel1.41417032
56MP0005076_abnormal_cell_differentiation1.41304237
57MP0001346_abnormal_lacrimal_gland1.40993272
58MP0004084_abnormal_cardiac_muscle1.40384099
59MP0006035_abnormal_mitochondrial_morpho1.40137639
60MP0010630_abnormal_cardiac_muscle1.39465573
61MP0004957_abnormal_blastocyst_morpholog1.37915064
62MP0002282_abnormal_trachea_morphology1.37810446
63MP0003890_abnormal_embryonic-extraembry1.37231111
64MP0004185_abnormal_adipocyte_glucose1.35318384
65MP0002106_abnormal_muscle_physiology1.34886197
66* MP0002114_abnormal_axial_skeleton1.34228440
67MP0000678_abnormal_parathyroid_gland1.33300358
68MP0005360_urolithiasis1.31900993
69MP0000653_abnormal_sex_gland1.31706972
70MP0001188_hyperpigmentation1.31216834
71MP0001293_anophthalmia1.28475194
72MP0005375_adipose_tissue_phenotype1.28080981
73MP0003045_fibrosis1.27630403
74MP0008877_abnormal_DNA_methylation1.27020535
75MP0006138_congestive_heart_failure1.25754364
76MP0004197_abnormal_fetal_growth/weight/1.24301194
77MP0000762_abnormal_tongue_morphology1.22108328
78MP0010352_gastrointestinal_tract_polyps1.20718735
79MP0005380_embryogenesis_phenotype1.19330618
80MP0001672_abnormal_embryogenesis/_devel1.19330618
81MP0000534_abnormal_ureter_morphology1.18085848
82MP0005058_abnormal_lysosome_morphology1.13606430
83MP0001849_ear_inflammation1.12461023
84MP0002088_abnormal_embryonic_growth/wei1.12438216
85MP0001348_abnormal_lacrimal_gland1.11881642
86MP0000049_abnormal_middle_ear1.11642218
87MP0003984_embryonic_growth_retardation1.08999351
88MP0002085_abnormal_embryonic_tissue1.07842864
89MP0000467_abnormal_esophagus_morphology1.07035157
90MP0005666_abnormal_adipose_tissue1.06831942
91MP0000750_abnormal_muscle_regeneration1.05742131
92MP0002092_abnormal_eye_morphology1.05296583
93MP0002233_abnormal_nose_morphology1.04805471
94MP0002132_abnormal_respiratory_system1.04770516
95MP0000432_abnormal_head_morphology1.04750048
96MP0003935_abnormal_craniofacial_develop1.04628676
97MP0005620_abnormal_muscle_contractility1.04427151
98MP0005508_abnormal_skeleton_morphology1.02494401
99MP0002160_abnormal_reproductive_system0.99668547
100MP0002970_abnormal_white_adipose0.98110781
101MP0004272_abnormal_basement_membrane0.97967639
102MP0003111_abnormal_nucleus_morphology0.97843917
103MP0002177_abnormal_outer_ear0.96807830
104MP0000759_abnormal_skeletal_muscle0.96656457
105MP0000428_abnormal_craniofacial_morphol0.96189548
106MP0002108_abnormal_muscle_morphology0.96178347
107MP0003806_abnormal_nucleotide_metabolis0.95229918
108MP0008007_abnormal_cellular_replicative0.94965361
109MP0003315_abnormal_perineum_morphology0.93949270
110MP0002938_white_spotting0.88132656
111MP0003755_abnormal_palate_morphology0.86837620
112MP0010368_abnormal_lymphatic_system0.86706307
113MP0009053_abnormal_anal_canal0.85173384
114MP0005367_renal/urinary_system_phenotyp0.85027903
115MP0000516_abnormal_urinary_system0.85027903
116MP0002116_abnormal_craniofacial_bone0.84307905
117MP0002109_abnormal_limb_morphology0.84188715
118MP0008932_abnormal_embryonic_tissue0.83930065
119MP0004145_abnormal_muscle_electrophysio0.83412533
120MP0005503_abnormal_tendon_morphology0.81111715
121MP0002086_abnormal_extraembryonic_tissu0.80723062
122MP0000733_abnormal_muscle_development0.80258742
123* MP0009250_abnormal_appendicular_skeleto0.79697140
124MP0000537_abnormal_urethra_morphology0.79298008
125MP0002084_abnormal_developmental_patter0.78855755
126MP0004043_abnormal_pH_regulation0.78706523
127MP0003077_abnormal_cell_cycle0.77728159
128MP0003115_abnormal_respiratory_system0.77711806
129MP0001730_embryonic_growth_arrest0.77325412
130MP0009703_decreased_birth_body0.77194901
131MP0002277_abnormal_respiratory_mucosa0.76420155
132MP0005501_abnormal_skin_physiology0.75918597
133MP0001697_abnormal_embryo_size0.74578815
134MP0000767_abnormal_smooth_muscle0.74576477
135MP0002928_abnormal_bile_duct0.74458592
136MP0002925_abnormal_cardiovascular_devel0.73829749
137MP0004808_abnormal_hematopoietic_stem0.73096433
138MP0008058_abnormal_DNA_repair0.72394106
139MP0009697_abnormal_copulation0.72292930
140MP0009780_abnormal_chondrocyte_physiolo0.72122917
141MP0006036_abnormal_mitochondrial_physio0.71540124
142MP0009115_abnormal_fat_cell0.71338148
143MP0002127_abnormal_cardiovascular_syste0.71008589
144MP0003283_abnormal_digestive_organ0.70887299
145MP0001664_abnormal_digestion0.70076496
146MP0002697_abnormal_eye_size0.69167624
147MP0002971_abnormal_brown_adipose0.68765921
148MP0010094_abnormal_chromosome_stability0.68533435
149MP0003879_abnormal_hair_cell0.68013137
150MP0003252_abnormal_bile_duct0.67512045
151MP0000350_abnormal_cell_proliferation0.66936705
152MP0005391_vision/eye_phenotype0.66905395
153MP0000358_abnormal_cell_content/0.66318218
154MP0000163_abnormal_cartilage_morphology0.66176416
155MP0001915_intracranial_hemorrhage0.61648643
156MP0001340_abnormal_eyelid_morphology0.60966902
157MP0002128_abnormal_blood_circulation0.60850989

Predicted human phenotypes

RankGene SetZ-score
1Respiratory insufficiency due to defective ciliary clearance (HP:0200073)8.60945045
2Absent/shortened dynein arms (HP:0200106)7.77993343
3Dynein arm defect of respiratory motile cilia (HP:0012255)7.77993343
4Muscle fiber inclusion bodies (HP:0100299)5.45519557
5Abnormal respiratory motile cilium physiology (HP:0012261)5.35185296
6Muscle fiber cytoplasmatic inclusion bodies (HP:0100303)5.34698894
7Nemaline bodies (HP:0003798)5.12317908
8Nasal polyposis (HP:0100582)4.96456064
9Exercise-induced myalgia (HP:0003738)4.91614198
10Abnormal respiratory motile cilium morphology (HP:0005938)4.87739692
11Abnormal respiratory epithelium morphology (HP:0012253)4.87739692
12Bilateral microphthalmos (HP:0007633)4.81514585
13Type 1 muscle fiber predominance (HP:0003803)4.73439043
14Hepatoblastoma (HP:0002884)4.63563731
15Chronic bronchitis (HP:0004469)4.50924429
16Rhinitis (HP:0012384)4.39383811
17Distal arthrogryposis (HP:0005684)4.39375328
18Myopathic facies (HP:0002058)4.35923471
19Abnormality of the lower motor neuron (HP:0002366)4.33934755
20Nephroblastoma (Wilms tumor) (HP:0002667)4.18563375
21Abnormal ciliary motility (HP:0012262)4.13152025
22Abnormality of the nasal mucosa (HP:0000433)4.12899637
23Embryonal renal neoplasm (HP:0011794)3.94864709
24Renal duplication (HP:0000075)3.75169917
25Ulnar deviation of the wrist (HP:0003049)3.52327655
26Muscle stiffness (HP:0003552)3.45718452
27Abnormality of skeletal muscle fiber size (HP:0012084)3.29183560
28Infertility (HP:0000789)3.28702819
29Exercise-induced muscle cramps (HP:0003710)3.26427975
30Centrally nucleated skeletal muscle fibers (HP:0003687)3.25161039
31Calcaneovalgus deformity (HP:0001848)3.21828329
32Subaortic stenosis (HP:0001682)3.21174413
33Abnormality of the left ventricular outflow tract (HP:0011103)3.21174413
34Increased variability in muscle fiber diameter (HP:0003557)3.18954336
35Spinal rigidity (HP:0003306)3.18746605
36Hyporeflexia of lower limbs (HP:0002600)3.15433497
37Round ear (HP:0100830)3.13810044
38Protrusio acetabuli (HP:0003179)3.00458155
39Double outlet right ventricle (HP:0001719)2.99318726
40Congenital malformation of the right heart (HP:0011723)2.99318726
41Multiple enchondromatosis (HP:0005701)2.97711111
42Supernumerary spleens (HP:0009799)2.96902891
43EMG: myopathic abnormalities (HP:0003458)2.94566399
44Sensory axonal neuropathy (HP:0003390)2.88274255
45Bifid tongue (HP:0010297)2.87201457
46Rhabdomyolysis (HP:0003201)2.86956031
47Hypochromic microcytic anemia (HP:0004840)2.80792435
48Muscle hypertrophy of the lower extremities (HP:0008968)2.78993631
49Abnormal lung lobation (HP:0002101)2.78692463
50Deformed tarsal bones (HP:0008119)2.75467810
51Abnormality of the aortic arch (HP:0012303)2.75382839
52Abnormal ventriculo-arterial connection (HP:0011563)2.75162212
53Transposition of the great arteries (HP:0001669)2.75162212
54Abnormal connection of the cardiac segments (HP:0011545)2.75162212
55Bulbar palsy (HP:0001283)2.73382343
56Nephronophthisis (HP:0000090)2.73153278
57Difficulty running (HP:0009046)2.68227986
58Ragged-red muscle fibers (HP:0003200)2.68028160
59Unilateral renal agenesis (HP:0000122)2.66076357
60Embryonal neoplasm (HP:0002898)2.66021420
61Muscle fiber splitting (HP:0003555)2.62923415
62Hypoplastic left heart (HP:0004383)2.61804877
63Neck muscle weakness (HP:0000467)2.60209721
64Increased connective tissue (HP:0009025)2.60017407
65Absent phalangeal crease (HP:0006109)2.59096102
66Abnormal umbilical cord blood vessels (HP:0011403)2.58305067
67Single umbilical artery (HP:0001195)2.58305067
68Abnormality of the fetal cardiovascular system (HP:0010948)2.58305067
69Hypoplastic heart (HP:0001961)2.57030674
70Cerebral aneurysm (HP:0004944)2.56164936
71Rib fusion (HP:0000902)2.55162964
72Bile duct proliferation (HP:0001408)2.53145383
73Abnormal biliary tract physiology (HP:0012439)2.53145383
74Molar tooth sign on MRI (HP:0002419)2.49888459
75Abnormality of midbrain morphology (HP:0002418)2.49888459
76Asymmetric septal hypertrophy (HP:0001670)2.48525795
77Amyotrophic lateral sclerosis (HP:0007354)2.48469440
78Impulsivity (HP:0100710)2.48076175
79Hyperacusis (HP:0010780)2.46860220
80Abnormality of the phalanges of the hallux (HP:0010057)2.39619730
81Short humerus (HP:0005792)2.35652416
82Bronchitis (HP:0012387)2.32976078
83Malignant hyperthermia (HP:0002047)2.32790964
84Vertebral compression fractures (HP:0002953)2.32469142
85Cystic liver disease (HP:0006706)2.31785263
86Progressive muscle weakness (HP:0003323)2.31669572
87Neoplasm of the heart (HP:0100544)2.30792584
88Rectal fistula (HP:0100590)2.28346498
89Rectovaginal fistula (HP:0000143)2.28346498
90Myoglobinuria (HP:0002913)2.27970077
91Deep venous thrombosis (HP:0002625)2.27307654
92Abnormality of the ileum (HP:0001549)2.26491824
93Mildly elevated creatine phosphokinase (HP:0008180)2.23657843
94Abnormality of the umbilical cord (HP:0010881)2.23319983
95Calf muscle hypertrophy (HP:0008981)2.22422931
96Meckel diverticulum (HP:0002245)2.21854580
97Aplasia/hypoplasia of the humerus (HP:0006507)2.21596227
98Neoplasm of striated muscle (HP:0009728)2.21581237
99Diastasis recti (HP:0001540)2.21491527
100Supernumerary ribs (HP:0005815)2.19121384
101Rimmed vacuoles (HP:0003805)2.17313324
102Abnormality of the calf musculature (HP:0001430)2.16790365
103Achilles tendon contracture (HP:0001771)2.16123520
104Preauricular pit (HP:0004467)2.15083138
105Periauricular skin pits (HP:0100277)2.15083138
106Facial cleft (HP:0002006)2.15043263
107Elbow flexion contracture (HP:0002987)2.13229748
108Abnormality of the distal phalanx of the thumb (HP:0009617)2.13171131
109Partial duplication of thumb phalanx (HP:0009944)2.10711094
110Popliteal pterygium (HP:0009756)2.10131630
111Abnormality of the salivary glands (HP:0010286)2.09390083
112Abnormality of the pulmonary veins (HP:0011718)2.08390650
113Abnormality of the Achilles tendon (HP:0005109)2.07160468
114Distal lower limb muscle weakness (HP:0009053)2.05123664
115Abnormality of the calcaneus (HP:0008364)2.04005236
116Bronchiectasis (HP:0002110)2.03766590
117Partial duplication of the phalanx of hand (HP:0009999)2.03068302
118Rectal prolapse (HP:0002035)2.02835396
119Ulnar bowing (HP:0003031)2.02825411
120Back pain (HP:0003418)2.00530917
121Gout (HP:0001997)1.97046843
122Supernumerary bones of the axial skeleton (HP:0009144)1.96583252
123Self-mutilation (HP:0000742)1.96458895
124Increased nuchal translucency (HP:0010880)1.94999122
125Hyperthyroidism (HP:0000836)1.94628217
126Septate vagina (HP:0001153)1.94011407
127Vaginal fistula (HP:0004320)1.93726655
128Fused cervical vertebrae (HP:0002949)1.91038075
129Spastic tetraparesis (HP:0001285)1.90670336
130Hypopigmentation of the fundus (HP:0007894)1.90561328
131Generalized amyotrophy (HP:0003700)1.89968620
132Reduced subcutaneous adipose tissue (HP:0003758)1.88823610
133Intestinal fistula (HP:0100819)1.88550751
134Abnormality of the renal medulla (HP:0100957)1.87729114
135Weak cry (HP:0001612)1.87047928
136Foot dorsiflexor weakness (HP:0009027)1.87013084
137Broad alveolar ridges (HP:0000187)1.86821571
138Breech presentation (HP:0001623)1.86666957
139Nasolacrimal duct obstruction (HP:0000579)1.86511367
140Muscle fibrillation (HP:0010546)1.86405031
141Dislocated radial head (HP:0003083)1.86280649
142Tongue fasciculations (HP:0001308)1.85477095
143Male infertility (HP:0003251)1.83655894
144Upper motor neuron abnormality (HP:0002127)1.83261173
145Abnormality of dentin (HP:0010299)1.82994054
146Abnormality of the foot musculature (HP:0001436)1.82843809
147Abnormal finger flexion creases (HP:0006143)1.81763722
148Aplasia/Hypoplasia of the 4th metacarpal (HP:0010042)1.81727823
149Short 4th metacarpal (HP:0010044)1.81727823
150Posterior embryotoxon (HP:0000627)1.81317782
151Scapular winging (HP:0003691)1.81204861
152Abnormality of the anterior chamber (HP:0000593)1.80900601
153Dyschromatopsia (HP:0007641)1.80870908
154Skin pits (HP:0100276)1.80528185
155Areflexia of lower limbs (HP:0002522)1.80420435
156Bowel diverticulosis (HP:0005222)1.80338268
157Neoplasm of the adrenal cortex (HP:0100641)1.79864060
158Pendular nystagmus (HP:0012043)1.77288104
159Horizontal nystagmus (HP:0000666)1.76881656
160Anomalous pulmonary venous return (HP:0010772)1.76853378
161Glioma (HP:0009733)1.76049162
162Abnormality of carpal bone ossification (HP:0006257)1.73961609
163Ependymoma (HP:0002888)1.73371686
164Fragile skin (HP:0001030)1.73249434
165Tubular atrophy (HP:0000092)1.72047599
166Abnormality of the radial head (HP:0003995)1.71657119
167Skin tags (HP:0010609)1.70622819
168Pancreatic islet-cell hyperplasia (HP:0004510)1.70375081
169Trismus (HP:0000211)1.69736035
170Hand muscle atrophy (HP:0009130)1.69440272
171Lip pit (HP:0100267)1.68581139
172Distal lower limb amyotrophy (HP:0008944)1.68527728
173Frequent falls (HP:0002359)1.68459354
174Adducted thumb (HP:0001181)1.68225752
175Preauricular skin tag (HP:0000384)1.67876091
176Heterotopia (HP:0002282)1.67704881
177Stridor (HP:0010307)1.67536140
178Premature rupture of membranes (HP:0001788)1.66754890
179Abnormality of the line of Schwalbe (HP:0008048)1.65546734
180Duodenal stenosis (HP:0100867)1.65263687
181Small intestinal stenosis (HP:0012848)1.65263687
182Metatarsus adductus (HP:0001840)1.64258160
183Hyperinsulinemic hypoglycemia (HP:0000825)1.63436872
184Abnormality of the tricuspid valve (HP:0001702)1.63066135
185Truncus arteriosus (HP:0001660)1.62839538
186Hypoplasia of the iris (HP:0007676)1.61929677
187Impaired proprioception (HP:0010831)1.61671023
188Thin ribs (HP:0000883)1.61668726
189Postaxial foot polydactyly (HP:0001830)1.61568521
190Nasal speech (HP:0001611)1.61317374
191Pterygium (HP:0001059)1.59808651

Predicted kinase interactions (KEA)

RankGene SetZ-score
1PDK45.61750695
2PDK35.61750695
3CDK125.27431393
4GRK53.81087685
5OBSCN3.50123869
6PDK23.43641207
7NME23.35355808
8ERN13.25066810
9TESK13.20396679
10TTK3.11034087
11IRAK32.95066048
12SMG12.59853467
13PRKD32.47262047
14ARAF2.45065574
15ICK2.35848557
16WNK12.33437404
17GRK62.31234064
18PHKG22.23189118
19PHKG12.23189118
20MATK2.19014687
21ADRBK22.17576108
22ZAK1.98322895
23TYRO31.93734820
24MAP3K131.91565272
25CSF1R1.73635085
26GRK11.71351283
27TGFBR21.67692624
28PTK2B1.55665426
29MST1R1.50772489
30PINK11.50023811
31MAP3K91.46818478
32CDK81.45897440
33WNK41.39998899
34MAPKAPK31.34052035
35STK101.32571311
36NEK21.31237764
37BRD41.30492612
38CHEK21.29408877
39STK381.26209089
40MAPK111.22993375
41MAPK71.19065725
42PAK41.15443481
43PDPK11.15297299
44MARK21.12501126
45LATS21.12500632
46BRAF1.11802596
47MAP3K101.11043728
48ILK1.10975032
49SCYL21.10385424
50RPS6KB21.06813859
51DYRK1B1.06010484
52STK391.03237134
53STK31.01067027
54LATS10.98881151
55GRK70.98873935
56PTK20.98802729
57TRIB30.98662618
58MOS0.98397592
59MAP3K60.97528853
60CDK90.96796251
61NTRK10.96093613
62MAP3K10.94186296
63MELK0.93764552
64PLK10.93381366
65PRKG20.92226748
66CAMK1G0.91095275
67MAP2K20.88381324
68CAMK40.85719534
69KSR20.84355168
70PRKCH0.83941479
71TTN0.78939530
72MTOR0.77097010
73NME10.76260797
74ADRBK10.73135756
75CHEK10.73056007
76PIK3CG0.72872642
77PAK20.72492859
78VRK20.70310926
79CSNK1A1L0.69253744
80EPHA20.68043532
81ABL20.67996046
82MAP2K60.67625820
83MARK30.66963179
84CDK70.66940180
85MAP2K40.66043747
86CDC70.64144498
87RIPK10.63626636
88MAP3K30.63470801
89TRPM70.60200436
90DYRK30.59420862
91FLT30.58907495
92PRPF4B0.56624088
93AURKA0.56362065
94PDGFRA0.55525977
95IRAK20.53466990
96CSK0.52956357
97PDK10.52502884
98RPS6KB10.52371668
99CDC42BPA0.52303421
100PASK0.51387972
101LIMK10.49890019
102RPS6KA20.49653068
103CSNK1G30.48430127
104EEF2K0.46362883
105BCKDK0.45218202
106MAP3K70.44148491
107EPHB20.43752016
108EIF2AK10.43205544
109TAOK20.42533249
110ATR0.42532200
111MAP2K10.42511725
112PAK10.42145036
113MAPKAPK50.41565594
114ATM0.41506996
115DDR20.41492637
116RPS6KA10.41240382
117CAMK1D0.40637535
118TIE10.40297181
119MUSK0.39337355
120NEK10.39300361
121PIM20.39081688
122MYLK0.37500753
123AKT20.36023108
124ALK0.35833403
125MAPKAPK20.35319304
126BUB10.35257444
127LRRK20.34477818
128DMPK0.33468226
129SIK20.32457292
130PNCK0.31779228
131RET0.30536927
132BRSK10.29785991
133IRAK10.29570383
134INSR0.29328666
135PTK60.28225759
136CDK20.28032738
137CSNK1E0.27151289
138STK38L0.24595578
139BMX0.24548711
140HIPK20.24078602
141CDK40.22856259
142PRKACB0.22673323
143CDK10.22344420
144PRKD20.20973701
145PRKCD0.19872879
146AURKB0.19589644
147MAP3K80.19159899
148IGF1R0.18820213
149CDK150.17693834
150FGFR30.17426543
151MET0.17288263
152GSK3B0.16992562
153MAPK120.16968237
154SIK10.16178178
155LMTK20.16117117
156GSK3A0.15576452
157PRKAA10.15263382
158MAP2K30.14570707
159TESK20.14544439
160SRC0.14181909
161PKN20.12488477
162CDK11A0.12113907

Predicted pathways (KEGG)

RankGene SetZ-score
1Vitamin B6 metabolism_Homo sapiens_hsa007508.04286188
2Glycolysis / Gluconeogenesis_Homo sapiens_hsa000102.86297833
3Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006032.79665271
4alpha-Linolenic acid metabolism_Homo sapiens_hsa005922.66379553
5Linoleic acid metabolism_Homo sapiens_hsa005912.64250288
6Fructose and mannose metabolism_Homo sapiens_hsa000512.56208544
7Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004002.55604058
82-Oxocarboxylic acid metabolism_Homo sapiens_hsa012102.02591379
9Arachidonic acid metabolism_Homo sapiens_hsa005902.02353364
10Propanoate metabolism_Homo sapiens_hsa006401.99219336
11Pyruvate metabolism_Homo sapiens_hsa006201.99128058
12Hedgehog signaling pathway_Homo sapiens_hsa043401.97732730
13Other glycan degradation_Homo sapiens_hsa005111.84235236
14Basal cell carcinoma_Homo sapiens_hsa052171.79695923
15Ribosome_Homo sapiens_hsa030101.76301725
16Circadian rhythm_Homo sapiens_hsa047101.75712175
17Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate_Homo sapiens_hsa005321.63843114
18Non-small cell lung cancer_Homo sapiens_hsa052231.63494346
19Fanconi anemia pathway_Homo sapiens_hsa034601.59721079
20Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030081.58386684
21Fatty acid biosynthesis_Homo sapiens_hsa000611.56602218
22Cell cycle_Homo sapiens_hsa041101.53657874
23Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009801.52768504
24Insulin signaling pathway_Homo sapiens_hsa049101.51179575
25Pancreatic cancer_Homo sapiens_hsa052121.51118028
26mRNA surveillance pathway_Homo sapiens_hsa030151.44575061
27RNA transport_Homo sapiens_hsa030131.41878151
28Phenylalanine metabolism_Homo sapiens_hsa003601.37213615
29Pentose phosphate pathway_Homo sapiens_hsa000301.36156519
30Carbon metabolism_Homo sapiens_hsa012001.35975765
31Arginine and proline metabolism_Homo sapiens_hsa003301.35741173
32Chronic myeloid leukemia_Homo sapiens_hsa052201.35503793
33Ubiquitin mediated proteolysis_Homo sapiens_hsa041201.35225770
34Lysine degradation_Homo sapiens_hsa003101.33230637
35PPAR signaling pathway_Homo sapiens_hsa033201.32263831
36Oocyte meiosis_Homo sapiens_hsa041141.28445552
37Basal transcription factors_Homo sapiens_hsa030221.26664792
38Dorso-ventral axis formation_Homo sapiens_hsa043201.26282190
39Glucagon signaling pathway_Homo sapiens_hsa049221.23917196
40Pentose and glucuronate interconversions_Homo sapiens_hsa000401.18021108
41Citrate cycle (TCA cycle)_Homo sapiens_hsa000201.17267349
42Selenocompound metabolism_Homo sapiens_hsa004501.15071647
43Galactose metabolism_Homo sapiens_hsa000521.14045177
44p53 signaling pathway_Homo sapiens_hsa041151.12496282
45Ether lipid metabolism_Homo sapiens_hsa005651.07348724
46Glycerophospholipid metabolism_Homo sapiens_hsa005641.06270245
47Glycerolipid metabolism_Homo sapiens_hsa005611.05361242
48One carbon pool by folate_Homo sapiens_hsa006701.04364377
49Arginine biosynthesis_Homo sapiens_hsa002201.04040521
50Glioma_Homo sapiens_hsa052141.03159259
51Insulin resistance_Homo sapiens_hsa049311.03135586
52Central carbon metabolism in cancer_Homo sapiens_hsa052301.02098633
53Other types of O-glycan biosynthesis_Homo sapiens_hsa005141.00227135
54Ovarian steroidogenesis_Homo sapiens_hsa049130.99017288
55Pyrimidine metabolism_Homo sapiens_hsa002400.97900551
56mTOR signaling pathway_Homo sapiens_hsa041500.96210692
57Protein processing in endoplasmic reticulum_Homo sapiens_hsa041410.95671917
58Base excision repair_Homo sapiens_hsa034100.95170117
59Spliceosome_Homo sapiens_hsa030400.94786154
60Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007600.93107855
61Cyanoamino acid metabolism_Homo sapiens_hsa004600.92866256
62Huntingtons disease_Homo sapiens_hsa050160.92548839
63Notch signaling pathway_Homo sapiens_hsa043300.88424179
64Thyroid cancer_Homo sapiens_hsa052160.88297291
65Cysteine and methionine metabolism_Homo sapiens_hsa002700.87627467
66Tryptophan metabolism_Homo sapiens_hsa003800.87137448
67Acute myeloid leukemia_Homo sapiens_hsa052210.86750393
68Neurotrophin signaling pathway_Homo sapiens_hsa047220.84215472
69Choline metabolism in cancer_Homo sapiens_hsa052310.83466822
70Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005120.81582197
71Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa049610.79492032
72Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001300.78515183
73Glycosaminoglycan degradation_Homo sapiens_hsa005310.78385148
74cGMP-PKG signaling pathway_Homo sapiens_hsa040220.77910543
75Hippo signaling pathway_Homo sapiens_hsa043900.77618477
76Cardiac muscle contraction_Homo sapiens_hsa042600.77497494
77Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa045500.76366891
78Prostate cancer_Homo sapiens_hsa052150.75989670
79Renal cell carcinoma_Homo sapiens_hsa052110.75922795
80AMPK signaling pathway_Homo sapiens_hsa041520.75872580
81Valine, leucine and isoleucine degradation_Homo sapiens_hsa002800.75351486
82Drug metabolism - other enzymes_Homo sapiens_hsa009830.75203077
83Longevity regulating pathway - multiple species_Homo sapiens_hsa042130.74742556
84Transcriptional misregulation in cancer_Homo sapiens_hsa052020.73939709
85Fatty acid degradation_Homo sapiens_hsa000710.73151526
86Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002500.72058536
87Protein digestion and absorption_Homo sapiens_hsa049740.71661276
88Starch and sucrose metabolism_Homo sapiens_hsa005000.71234395
89Thyroid hormone signaling pathway_Homo sapiens_hsa049190.69237888
90Prion diseases_Homo sapiens_hsa050200.69138514
91FoxO signaling pathway_Homo sapiens_hsa040680.67899621
92Endometrial cancer_Homo sapiens_hsa052130.67658723
93Chemical carcinogenesis_Homo sapiens_hsa052040.66626207
94Fatty acid metabolism_Homo sapiens_hsa012120.65545842
95Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa005340.64709018
96Inositol phosphate metabolism_Homo sapiens_hsa005620.64646248
97Melanoma_Homo sapiens_hsa052180.63266685
98Phospholipase D signaling pathway_Homo sapiens_hsa040720.61817937
99VEGF signaling pathway_Homo sapiens_hsa043700.61720461
100RNA polymerase_Homo sapiens_hsa030200.61480652
101Renin-angiotensin system_Homo sapiens_hsa046140.61142183
102Purine metabolism_Homo sapiens_hsa002300.60399863
103ErbB signaling pathway_Homo sapiens_hsa040120.59763283
104Sulfur relay system_Homo sapiens_hsa041220.59210452
105Amyotrophic lateral sclerosis (ALS)_Homo sapiens_hsa050140.58994321
106Pathways in cancer_Homo sapiens_hsa052000.58496487
107DNA replication_Homo sapiens_hsa030300.57736905
108Proteoglycans in cancer_Homo sapiens_hsa052050.57383724
109PI3K-Akt signaling pathway_Homo sapiens_hsa041510.56554948
110N-Glycan biosynthesis_Homo sapiens_hsa005100.54976746
111Nucleotide excision repair_Homo sapiens_hsa034200.54703962
112Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049640.54642410
113Tyrosine metabolism_Homo sapiens_hsa003500.54456579
114Regulation of actin cytoskeleton_Homo sapiens_hsa048100.52396468
115HTLV-I infection_Homo sapiens_hsa051660.52322650
116Vasopressin-regulated water reabsorption_Homo sapiens_hsa049620.52057057
117Wnt signaling pathway_Homo sapiens_hsa043100.51749452
118Glycine, serine and threonine metabolism_Homo sapiens_hsa002600.51533911
119Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa005200.51042505
120Arrhythmogenic right ventricular cardiomyopathy (ARVC)_Homo sapiens_hsa054120.50874752
121MicroRNAs in cancer_Homo sapiens_hsa052060.50234587
122Sulfur metabolism_Homo sapiens_hsa009200.49065043
123Small cell lung cancer_Homo sapiens_hsa052220.48299693
124Tight junction_Homo sapiens_hsa045300.47625000
125Hypertrophic cardiomyopathy (HCM)_Homo sapiens_hsa054100.46929123
126Adipocytokine signaling pathway_Homo sapiens_hsa049200.45073413
127Sphingolipid metabolism_Homo sapiens_hsa006000.43615942
128Rap1 signaling pathway_Homo sapiens_hsa040150.43488667
129Amoebiasis_Homo sapiens_hsa051460.43029690
130Glutathione metabolism_Homo sapiens_hsa004800.42333366
131Progesterone-mediated oocyte maturation_Homo sapiens_hsa049140.42065167
132Biosynthesis of amino acids_Homo sapiens_hsa012300.41552784
133Colorectal cancer_Homo sapiens_hsa052100.41324563
134Phosphatidylinositol signaling system_Homo sapiens_hsa040700.40162103
135Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa047500.39938397
136Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa049600.39613670
137ECM-receptor interaction_Homo sapiens_hsa045120.37530939
138Focal adhesion_Homo sapiens_hsa045100.36401704
139Dilated cardiomyopathy_Homo sapiens_hsa054140.35884807
140Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005630.35867751
141Regulation of lipolysis in adipocytes_Homo sapiens_hsa049230.35757929
142Vascular smooth muscle contraction_Homo sapiens_hsa042700.35715203
143RNA degradation_Homo sapiens_hsa030180.35633749
144Viral carcinogenesis_Homo sapiens_hsa052030.35534137
145Fc epsilon RI signaling pathway_Homo sapiens_hsa046640.33649869
146Retinol metabolism_Homo sapiens_hsa008300.33235871
147Metabolic pathways_Homo sapiens_hsa011000.32180714
148Ras signaling pathway_Homo sapiens_hsa040140.31256754
149Carbohydrate digestion and absorption_Homo sapiens_hsa049730.30943952
150Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006300.29936019
151Longevity regulating pathway - mammal_Homo sapiens_hsa042110.28902104
152ABC transporters_Homo sapiens_hsa020100.28800690
153Endocytosis_Homo sapiens_hsa041440.26908789
154Bladder cancer_Homo sapiens_hsa052190.26898741

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