HOXA5

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: In vertebrates, the genes encoding the class of transcription factors called homeobox genes are found in clusters named A, B, C, and D on four separate chromosomes. Expression of these proteins is spatially and temporally regulated during embryonic development. This gene is part of the A cluster on chromosome 7 and encodes a DNA-binding transcription factor which may regulate gene expression, morphogenesis, and differentiation. Methylation of this gene may result in the loss of its expression and, since the encoded protein upregulates the tumor suppressor p53, this protein may play an important role in tumorigenesis. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1ribosomal small subunit assembly (GO:0000028)9.42757240
2viral transcription (GO:0019083)8.29264081
3translational termination (GO:0006415)7.94234938
4definitive hemopoiesis (GO:0060216)6.78434206
5translational elongation (GO:0006414)6.69622968
6ribosomal small subunit biogenesis (GO:0042274)6.61462536
7SRP-dependent cotranslational protein targeting to membrane (GO:0006614)6.58264805
8protein targeting to ER (GO:0045047)6.42766693
9cotranslational protein targeting to membrane (GO:0006613)6.42296135
10nuclear-transcribed mRNA catabolic process, nonsense-mediated decay (GO:0000184)6.15554234
11establishment of protein localization to endoplasmic reticulum (GO:0072599)6.13843735
12viral life cycle (GO:0019058)6.11233272
13protein localization to endoplasmic reticulum (GO:0070972)6.01747251
14cellular protein complex disassembly (GO:0043624)5.99067187
15maturation of SSU-rRNA (GO:0030490)5.89248414
16embryonic skeletal joint morphogenesis (GO:0060272)5.67312912
17facial nerve structural organization (GO:0021612)5.46102588
18regulation of single stranded viral RNA replication via double stranded DNA intermediate (GO:00450915.44483491
19protein complex disassembly (GO:0043241)5.32365235
20translational initiation (GO:0006413)5.25667760
21macromolecular complex disassembly (GO:0032984)4.92100006
22grooming behavior (GO:0007625)4.59776085
23cranial nerve morphogenesis (GO:0021602)4.59428626
24peripheral nervous system neuron development (GO:0048935)4.49311012
25protein targeting to membrane (GO:0006612)4.40492983
26nuclear-transcribed mRNA catabolic process (GO:0000956)4.33964554
27megakaryocyte development (GO:0035855)4.29011591
28mRNA catabolic process (GO:0006402)4.17729611
29platelet dense granule organization (GO:0060155)4.16943255
30embryonic heart tube development (GO:0035050)4.13693074
31ribosomal large subunit biogenesis (GO:0042273)4.04513494
32organ induction (GO:0001759)4.04023281
33pharyngeal system development (GO:0060037)4.00721246
34cranial nerve structural organization (GO:0021604)3.99154913
35regulation of female receptivity (GO:0045924)3.94293850
36outer ear morphogenesis (GO:0042473)3.91932565
37response to interferon-alpha (GO:0035455)3.91268565
38* anterior/posterior pattern specification (GO:0009952)3.87928408
39RNA catabolic process (GO:0006401)3.84643909
40lymphoid progenitor cell differentiation (GO:0002320)3.83969427
41DNA replication checkpoint (GO:0000076)3.78807769
42negative regulation of B cell apoptotic process (GO:0002903)3.76178313
43DNA deamination (GO:0045006)3.74416194
44muscle cell fate commitment (GO:0042693)3.66423598
45outflow tract septum morphogenesis (GO:0003148)3.63834426
46response to interferon-beta (GO:0035456)3.62504636
47metanephros development (GO:0001656)3.59225847
48* embryonic organ morphogenesis (GO:0048562)3.55816868
49cellular response to ATP (GO:0071318)3.51639568
50aggressive behavior (GO:0002118)3.50064706
51phospholipid scrambling (GO:0017121)3.49188438
52female mating behavior (GO:0060180)3.44220468
53regulation of organ formation (GO:0003156)3.42833845
54* thyroid gland development (GO:0030878)3.41206695
55* regulation of mammary gland epithelial cell proliferation (GO:0033599)3.39167620
56regulation of apoptotic process involved in morphogenesis (GO:1902337)3.30102258
57antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-independent (G3.29685667
58pattern specification involved in kidney development (GO:0061004)3.29072871
59morphogenesis of an epithelial fold (GO:0060571)3.27780493
60translation (GO:0006412)3.27271251
61mesenchymal to epithelial transition involved in metanephros morphogenesis (GO:0003337)3.26898247
62dosage compensation (GO:0007549)3.26089632
63positive regulation of fatty acid oxidation (GO:0046321)3.25283241
64cartilage development involved in endochondral bone morphogenesis (GO:0060351)3.19381422
65negative regulation of DNA-templated transcription, elongation (GO:0032785)3.17468230
66pseudouridine synthesis (GO:0001522)3.16405544
67embryonic viscerocranium morphogenesis (GO:0048703)3.14965360
68L-fucose metabolic process (GO:0042354)3.13138385
69L-fucose catabolic process (GO:0042355)3.13138385
70fucose catabolic process (GO:0019317)3.13138385
71mesonephros development (GO:0001823)3.11988145
72kidney mesenchyme development (GO:0072074)3.11958419
73regulation of glomerulus development (GO:0090192)3.10193300
74mesenchymal to epithelial transition (GO:0060231)3.09268749
75urogenital system development (GO:0001655)3.08894975
76regulation of secondary heart field cardioblast proliferation (GO:0003266)3.07143669
77regulation of cardioblast proliferation (GO:0003264)3.07143669
78UV protection (GO:0009650)3.06929203
79formation of translation preinitiation complex (GO:0001731)3.06388937
80tooth mineralization (GO:0034505)3.05975475
81negative regulation of transcription elongation from RNA polymerase II promoter (GO:0034244)3.04818686
82secretory granule organization (GO:0033363)3.04684016
83* mammary gland epithelial cell differentiation (GO:0060644)3.04459080
84glucocorticoid biosynthetic process (GO:0006704)3.03806574
85folic acid metabolic process (GO:0046655)3.00831186
86negative regulation of mRNA processing (GO:0050686)2.99060705
87negative regulation of viral entry into host cell (GO:0046597)2.98997254
88behavioral response to nicotine (GO:0035095)2.98487833
89ribonucleoprotein complex biogenesis (GO:0022613)2.96681558
90positive regulation of fatty acid beta-oxidation (GO:0032000)2.95995009
91pyrimidine deoxyribonucleotide catabolic process (GO:0009223)2.94595727
92regulation of nuclear cell cycle DNA replication (GO:0033262)2.94397823
93uterus development (GO:0060065)2.93147075
94antigen processing and presentation of endogenous peptide antigen (GO:0002483)2.91510504
95antigen processing and presentation of endogenous peptide antigen via MHC class I (GO:0019885)2.91510504
96establishment of protein localization to membrane (GO:0090150)2.91017568
97negative regulation of homotypic cell-cell adhesion (GO:0034111)2.90330379
98germ cell migration (GO:0008354)2.89911121
99regulation of chromatin binding (GO:0035561)2.89852889
100positive regulation of muscle cell apoptotic process (GO:0010661)2.88746920
101* negative regulation of erythrocyte differentiation (GO:0045647)2.88203122
102neuron fate specification (GO:0048665)2.87968622
103negative regulation of vascular endothelial growth factor receptor signaling pathway (GO:0030948)2.86449582
104aorta morphogenesis (GO:0035909)2.85058223
105embryonic forelimb morphogenesis (GO:0035115)2.84699888
106antigen processing and presentation via MHC class Ib (GO:0002475)2.83843266
107heparin metabolic process (GO:0030202)2.83666150
108heparin biosynthetic process (GO:0030210)2.83666150
109mature B cell differentiation involved in immune response (GO:0002313)2.82330761
110cellular anion homeostasis (GO:0030002)2.81165302
111* embryonic skeletal system morphogenesis (GO:0048704)2.75877000
112mitochondrial respiratory chain complex I biogenesis (GO:0097031)2.75672893
113mitochondrial respiratory chain complex I assembly (GO:0032981)2.75672893
114NADH dehydrogenase complex assembly (GO:0010257)2.75672893
115cardiac muscle cell proliferation (GO:0060038)2.75651985
116endosome to pigment granule transport (GO:0043485)2.75520317
117endosome to melanosome transport (GO:0035646)2.75520317
118negative regulation of RNA splicing (GO:0033119)2.75215066
119* regionalization (GO:0003002)2.75171552
120regulation of mesenchymal cell apoptotic process (GO:2001053)2.73347218
121branching involved in prostate gland morphogenesis (GO:0060442)2.72987850
122glucose 6-phosphate metabolic process (GO:0051156)2.70599101
123negative regulation of lipopolysaccharide-mediated signaling pathway (GO:0031665)2.70392450
124forelimb morphogenesis (GO:0035136)2.67845285
125positive regulation of glomerulus development (GO:0090193)2.67704004
126regulation of heart morphogenesis (GO:2000826)2.67149345
127anatomical structure arrangement (GO:0048532)2.66259294
128white fat cell differentiation (GO:0050872)2.66100236
129tRNA methylation (GO:0030488)2.65515107
130lymph vessel development (GO:0001945)2.64660727
131CD4-positive or CD8-positive, alpha-beta T cell lineage commitment (GO:0043369)2.63978770
132developmental induction (GO:0031128)2.62952848
133rRNA catabolic process (GO:0016075)2.61058553
134negative regulation of T cell differentiation in thymus (GO:0033085)2.60723671
135rRNA processing (GO:0006364)2.60380870
136diaphragm development (GO:0060539)2.59531305
137regulation of fatty acid beta-oxidation (GO:0031998)2.58815819
138blood vessel maturation (GO:0001955)2.57579652
139negative regulation of leukocyte chemotaxis (GO:0002689)2.57114367
140protein targeting (GO:0006605)2.57097022
141negative regulation of viral genome replication (GO:0045071)2.56954665
142proximal/distal pattern formation (GO:0009954)2.52277087
143respiratory chain complex IV assembly (GO:0008535)2.47938756
144regulation of stem cell maintenance (GO:2000036)2.47627731
145negative regulation of phagocytosis (GO:0050765)2.47027767
146negative regulation of kidney development (GO:0090185)2.46914967
147cell differentiation involved in metanephros development (GO:0072202)2.45292549
148organ formation (GO:0048645)2.44677159
149mesodermal cell differentiation (GO:0048333)2.43088860
150lymph node development (GO:0048535)2.42032901
151middle ear morphogenesis (GO:0042474)2.41439171
152* skeletal system morphogenesis (GO:0048705)2.40878206
153establishment of protein localization to organelle (GO:0072594)2.39421928
154segment specification (GO:0007379)2.39094085
155dorsal/ventral neural tube patterning (GO:0021904)2.37243981
156protein localization to membrane (GO:0072657)2.31392704
157negative regulation of mRNA splicing, via spliceosome (GO:0048025)2.31083345
158cellular component biogenesis (GO:0044085)2.31062486
159mesenchymal cell differentiation involved in kidney development (GO:0072161)2.30748253
160mesenchymal cell differentiation involved in renal system development (GO:2001012)2.30748253
161intra-S DNA damage checkpoint (GO:0031573)2.30630505
162negative regulation of metanephros development (GO:0072217)2.30173218
163neural crest cell development (GO:0014032)2.29972063
164negative regulation of DNA repair (GO:0045738)2.29560499
165activation of transmembrane receptor protein tyrosine kinase activity (GO:0007171)2.29087198
166negative regulation by host of viral transcription (GO:0043922)2.28478155
167negative regulation of type 2 immune response (GO:0002829)2.28114191

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1TP63_17297297_ChIP-ChIP_HaCaT_Human4.80369223
2SCL_19346495_ChIP-Seq_HPC-7_Human4.74485664
3RBPJ_22232070_ChIP-Seq_NCS_Mouse4.49740718
4SOX9_22984422_ChIP-ChIP_TESTIS_Rat3.90540105
5MYC_18555785_ChIP-Seq_MESCs_Mouse3.78790753
6HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse3.75129029
7* CHD7_19251738_ChIP-ChIP_MESCs_Mouse3.13359122
8EKLF_21900194_ChIP-Seq_ERYTHROCYTE_Mouse3.01318739
9* TP63_19390658_ChIP-ChIP_HaCaT_Human2.97942882
10TAL1_20887958_ChIP-Seq_HPC-7_Mouse2.76216223
11CIITA_18437201_ChIP-ChIP_Raji_B_and_iDC_Human2.71423988
12TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat2.67066966
13SPI1_22790984_ChIP-Seq_ERYTHROLEUKEMIA_Mouse2.66624732
14* EED_16625203_ChIP-ChIP_MESCs_Mouse2.59403471
15RUNX1_20887958_ChIP-Seq_HPC-7_Mouse2.52176693
16* CBX2_27304074_Chip-Seq_ESCs_Mouse2.48707386
17MECOM_23826213_ChIP-Seq_KASUMI_Mouse2.47575197
18* BMI1_23680149_ChIP-Seq_NPCS_Mouse2.40594669
19* EZH2_27304074_Chip-Seq_ESCs_Mouse2.38300362
20* JARID2_20064375_ChIP-Seq_MESCs_Mouse2.35805967
21HCFC1_20581084_ChIP-Seq_MESCs_Mouse2.32407419
22IRF8_22096565_ChIP-ChIP_GC-B_Mouse2.31231497
23* JARID2_20075857_ChIP-Seq_MESCs_Mouse2.29619073
24JARID1A_20064375_ChIP-Seq_MESCs_Mouse2.24080826
25FLI1_20887958_ChIP-Seq_HPC-7_Mouse2.22833032
26TET1_21451524_ChIP-Seq_MESCs_Mouse2.20048406
27ELF1_17652178_ChIP-ChIP_JURKAT_Human2.16273117
28* EZH2_18974828_ChIP-Seq_MESCs_Mouse2.10969552
29* RNF2_18974828_ChIP-Seq_MESCs_Mouse2.10969552
30MYC_19079543_ChIP-ChIP_MESCs_Mouse2.10591431
31ESR1_15608294_ChIP-ChIP_MCF-7_Human2.09134657
32NOTCH1_21737748_ChIP-Seq_TLL_Human2.06083895
33TRP63_18441228_ChIP-ChIP_KERATINOCYTES_Mouse2.03446369
34STAT6_21828071_ChIP-Seq_BEAS2B_Human2.03194953
35IRF8_22096565_ChIP-ChIP_GC-B_Human2.02276431
36ERG_20887958_ChIP-Seq_HPC-7_Mouse2.01374101
37MYC_22102868_ChIP-Seq_BL_Human1.98868265
38ZNF652_21678463_ChIP-ChIP_ZR75-1_Human1.96961845
39MYB_21317192_ChIP-Seq_ERMYB_Mouse1.95032159
40CEBPB_24764292_ChIP-Seq_MC3T3_Mouse1.94686390
41XRN2_22483619_ChIP-Seq_HELA_Human1.93146432
42SPI1_22096565_ChIP-ChIP_GC-B_Mouse1.89885160
43HOXB4_20404135_ChIP-ChIP_EML_Mouse1.89239411
44VDR_21846776_ChIP-Seq_THP-1_Human1.83989393
45LYL1_20887958_ChIP-Seq_HPC-7_Mouse1.83490503
46DACH1_20351289_ChIP-Seq_MDA-MB-231_Human1.82230644
47* TTF2_22483619_ChIP-Seq_HELA_Human1.81717226
48EZH2_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse1.77537651
49E2F7_22180533_ChIP-Seq_HELA_Human1.76991254
50MYC_18358816_ChIP-ChIP_MESCs_Mouse1.75929074
51GABP_17652178_ChIP-ChIP_JURKAT_Human1.75321541
52SPI1_23547873_ChIP-Seq_NB4_Human1.73297385
53RNF2_27304074_Chip-Seq_NSC_Mouse1.71191606
54* CDX2_20551321_ChIP-Seq_CACO-2_Human1.70031806
55* P68_20966046_ChIP-Seq_HELA_Human1.68223983
56KDM5A_27292631_Chip-Seq_BREAST_Human1.66589225
57KDM2B_26808549_Chip-Seq_SIL-ALL_Human1.65618623
58MYC_19030024_ChIP-ChIP_MESCs_Mouse1.65245860
59PPARG_19300518_ChIP-PET_3T3-L1_Mouse1.64508721
60BP1_19119308_ChIP-ChIP_Hs578T_Human1.64452775
61GATA2_21666600_ChIP-Seq_HMVEC_Human1.64009161
62THAP11_20581084_ChIP-Seq_MESCs_Mouse1.63077604
63ELK1_19687146_ChIP-ChIP_HELA_Human1.62525669
64STAT6_20620947_ChIP-Seq_CD4_POS_T_Human1.56578713
65FOXM1_25889361_ChIP-Seq_OE33_AND_U2OS_Human1.55636171
66SFPI1_20887958_ChIP-Seq_HPC-7_Mouse1.52237978
67VDR_23849224_ChIP-Seq_CD4+_Human1.51711237
68* GFI1B_20887958_ChIP-Seq_HPC-7_Mouse1.50052433
69* RNF2_16625203_ChIP-ChIP_MESCs_Mouse1.47594217
70IRF1_21803131_ChIP-Seq_MONOCYTES_Human1.45516197
71* KLF4_19030024_ChIP-ChIP_MESCs_Mouse1.44268736
72* SUZ12_18692474_ChIP-Seq_MEFs_Mouse1.42472696
73VDR_24763502_ChIP-Seq_THP-1_Human1.41669019
74GABP_19822575_ChIP-Seq_HepG2_Human1.40878150
75EST1_17652178_ChIP-ChIP_JURKAT_Human1.40706792
76MAF_26560356_Chip-Seq_TH1_Human1.40317634
77ELF1_20517297_ChIP-Seq_JURKAT_Human1.39949107
78FOXP3_17237761_ChIP-ChIP_TREG_Mouse1.39620597
79LXR_22292898_ChIP-Seq_THP-1_Human1.39589350
80STAT3_19079543_ChIP-ChIP_MESCs_Mouse1.36762341
81* PHC1_16625203_ChIP-ChIP_MESCs_Mouse1.36197427
82ASXL1_24218140_ChIP-Seq_BMDM_Mouse1.35853814
83* BCL3_23251550_ChIP-Seq_MUSCLE_Mouse1.35808036
84HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human1.35283609
85RUNX1_22412390_ChIP-Seq_EML_Mouse1.34445944
86* SUZ12_16625203_ChIP-ChIP_MESCs_Mouse1.34010886
87CCND1_20090754_ChIP-ChIP_RETINA_Mouse1.32554614
88TCF7_22412390_ChIP-Seq_EML_Mouse1.31049058
89LMO2_20887958_ChIP-Seq_HPC-7_Mouse1.29906261
90* ELK3_25401928_ChIP-Seq_HUVEC_Human1.29416169
91TBP_23326641_ChIP-Seq_C3H10T1-2_Mouse1.29348784
92E2F4_17652178_ChIP-ChIP_JURKAT_Human1.28943509
93FOXO3_22982991_ChIP-Seq_MACROPHAGES_Mouse1.28919869
94* EZH2_27294783_Chip-Seq_ESCs_Mouse1.28785052
95CREB1_23762244_ChIP-Seq_HIPPOCAMPUS_Rat1.27417483
96CTCF_27219007_Chip-Seq_ERYTHROID_Human1.27255632
97MEIS1_20887958_ChIP-Seq_HPC-7_Mouse1.26867958
98CTNNB1_20615089_ChIP-ChIP_FETAL_BRAIN_Human1.26571437
99* BCL6_27268052_Chip-Seq_Bcells_Human1.25534938
100RARG_19884340_ChIP-ChIP_MEFs_Mouse1.24598647
101ELK1_22589737_ChIP-Seq_MCF10A_Human1.24448692
102GATA2_20887958_ChIP-Seq_HPC-7_Mouse1.24240602
103* TP53_22127205_ChIP-Seq_IMR90_Human1.24063810
104ZFX_18555785_ChIP-Seq_MESCs_Mouse1.23285367
105SA1_27219007_Chip-Seq_ERYTHROID_Human1.22864719
106FOXP1_21924763_ChIP-Seq_HESCs_Human1.22722548
107KLF2_18264089_ChIP-ChIP_MESCs_Mouse1.22549803
108KLF5_18264089_ChIP-ChIP_MESCs_Mouse1.22549803
109KLF4_18264089_ChIP-ChIP_MESCs_Mouse1.22549803
110* SMAD2_18955504_ChIP-ChIP_HaCaT_Human1.22007556
111* SMAD3_18955504_ChIP-ChIP_HaCaT_Human1.22007556
112CREB1_15753290_ChIP-ChIP_HEK293T_Human1.21034137
113ETS1_20019798_ChIP-Seq_JURKAT_Human1.20850846
114E2F1_18555785_ChIP-Seq_MESCs_Mouse1.20045623
115STAT4_19710469_ChIP-ChIP_TH1__Mouse1.18704945
116MYBL1_21750041_ChIP-ChIP_SPERMATOCYTES_Mouse1.18501883
117KDM2B_26808549_Chip-Seq_SUP-B15_Human1.17961432
118NELFA_20434984_ChIP-Seq_ESCs_Mouse1.15488752
119CREB1_26743006_Chip-Seq_LNCaP-abl_Human1.14688241
120UTX_26944678_Chip-Seq_JUKART_Human1.14182426
121FOXP3_21729870_ChIP-Seq_TREG_Human1.14044284
122GATA1_22383799_ChIP-Seq_G1ME_Mouse1.13984957
123MYCN_27167114_Chip-Seq_NEUROBLASTOMA_Human1.13862496
124KDM2B_26808549_Chip-Seq_DND41_Human1.13135177
125YY1_21170310_ChIP-Seq_MESCs_Mouse1.12862529
126CREB1_26743006_Chip-Seq_LNCaP_Human1.12070031
127SUZ12_27294783_Chip-Seq_ESCs_Mouse1.11922702
128EGR1_19032775_ChIP-ChIP_M12_Human1.11827308
129SMAD4_19686287_ChIP-ChIP_HaCaT_Human1.11520422
130GATA2_22383799_ChIP-Seq_G1ME_Mouse1.10088145
131IRF1_19129219_ChIP-ChIP_H3396_Human1.09661340
132RING1B_27294783_Chip-Seq_NPCs_Mouse1.09604344
133CHD1_19587682_ChIP-ChIP_MESCs_Mouse1.09531412
134PKCTHETA_26484144_Chip-Seq_BREAST_Human1.08493469
135CTCF_26484167_Chip-Seq_Bcells_Mouse1.07483722
136RACK7_27058665_Chip-Seq_MCF-7_Human1.06313918
137CTCF_21964334_ChIP-Seq_BJAB-B_Human1.05928209
138YY1_22570637_ChIP-Seq_MALME-3M_Human1.05048788
139KDM2B_26808549_Chip-Seq_HPB-ALL_Human1.04150404
140E2F1_20622854_ChIP-Seq_HELA_Human1.03572915
141* CTCF_18555785_ChIP-Seq_MESCs_Mouse1.02812688
142RING1B_27294783_Chip-Seq_ESCs_Mouse1.02494123
143NOTCH1_17114293_ChIP-ChIP_T-ALL_Human1.01759925
144POU5F1_16153702_ChIP-ChIP_HESCs_Human1.00891396
145MYBL2_22936984_ChIP-ChIP_MESCs_Mouse1.00868475
146MYB_26560356_Chip-Seq_TH1_Human0.99748128
147CIITA_25753668_ChIP-Seq_RAJI_Human0.99387943
148* PHF8_20622854_ChIP-Seq_HELA_Human0.98751424
149KDM2B_26808549_Chip-Seq_JURKAT_Human0.98441956
150E2F4_21247883_ChIP-Seq_LYMPHOBLASTOID_Human0.98430989
151MYB_26560356_Chip-Seq_TH2_Human0.98065396
152MAF_26560356_Chip-Seq_TH2_Human0.96394839
153MYC_18940864_ChIP-ChIP_HL60_Human0.96192569
154PPARG_23326641_ChIP-Seq_C3H10T1-2_Mouse0.95379339
155ZFP42_18358816_ChIP-ChIP_MESCs_Mouse0.95283296
156NCOR_22465074_ChIP-Seq_MACROPHAGES_Mouse0.94507779
157* TP53_20018659_ChIP-ChIP_R1E_Mouse0.93293905
158TAL1_20566737_ChIP-Seq_PRIMARY_FETAL_LIVER_ERYTHROID_Mouse0.91919531
159* CNOT3_19339689_ChIP-ChIP_MESCs_Mouse0.89111493
160CUX1_19635798_ChIP-ChIP_MULTIPLE_HUMAN_CANCER_TYPES_Human0.88601040
161EGR1_19374776_ChIP-ChIP_THP-1_Human0.87072057
162E2F1_21310950_ChIP-Seq_MCF-7_Human0.85245614

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0009379_abnormal_foot_pigmentation4.42635533
2MP0002160_abnormal_reproductive_system3.99889939
3MP0005670_abnormal_white_adipose3.61737025
4MP0002132_abnormal_respiratory_system2.99602522
5MP0009053_abnormal_anal_canal2.94776709
6MP0010368_abnormal_lymphatic_system2.88056337
7MP0004185_abnormal_adipocyte_glucose2.68524100
8MP0001879_abnormal_lymphatic_vessel2.60451181
9MP0004808_abnormal_hematopoietic_stem2.54699932
10MP0002396_abnormal_hematopoietic_system2.49862024
11MP0001346_abnormal_lacrimal_gland2.49088897
12MP0000678_abnormal_parathyroid_gland2.34278784
13* MP0002249_abnormal_larynx_morphology2.32022394
14MP0005646_abnormal_pituitary_gland2.31325778
15MP0000013_abnormal_adipose_tissue2.24549127
16MP0005174_abnormal_tail_pigmentation2.15825413
17MP0002234_abnormal_pharynx_morphology2.01645284
18MP0006054_spinal_hemorrhage1.95803728
19MP0003315_abnormal_perineum_morphology1.95537311
20MP0000049_abnormal_middle_ear1.93569313
21MP0001545_abnormal_hematopoietic_system1.92601146
22MP0005397_hematopoietic_system_phenotyp1.92601146
23MP0000465_gastrointestinal_hemorrhage1.92491444
24MP0005389_reproductive_system_phenotype1.91047620
25MP0002009_preneoplasia1.78822938
26MP0009250_abnormal_appendicular_skeleto1.78572417
27MP0003942_abnormal_urinary_system1.75823834
28MP0002166_altered_tumor_susceptibility1.74230592
29MP0000372_irregular_coat_pigmentation1.74172090
30MP0010030_abnormal_orbit_morphology1.73446484
31MP0004130_abnormal_muscle_cell1.68077706
32MP0005409_darkened_coat_color1.68028652
33MP0000003_abnormal_adipose_tissue1.66624920
34MP0008995_early_reproductive_senescence1.65258842
35MP0001293_anophthalmia1.62503279
36MP0002938_white_spotting1.60311635
37* MP0002282_abnormal_trachea_morphology1.59038935
38MP0002095_abnormal_skin_pigmentation1.58034779
39MP0003693_abnormal_embryo_hatching1.57934994
40MP0003941_abnormal_skin_development1.57775295
41MP0001958_emphysema1.55387916
42MP0000490_abnormal_crypts_of1.55256645
43MP0003123_paternal_imprinting1.52674414
44MP0003385_abnormal_body_wall1.52293233
45MP0003011_delayed_dark_adaptation1.51966200
46MP0003786_premature_aging1.49462969
47MP0003567_abnormal_fetal_cardiomyocyte1.46885085
48MP0002102_abnormal_ear_morphology1.45634208
49MP0010234_abnormal_vibrissa_follicle1.43697656
50MP0005075_abnormal_melanosome_morpholog1.43675147
51MP0005666_abnormal_adipose_tissue1.42097962
52MP0001661_extended_life_span1.41869836
53MP0005187_abnormal_penis_morphology1.41409778
54MP0000631_abnormal_neuroendocrine_gland1.40439311
55MP0005464_abnormal_platelet_physiology1.40226210
56MP0002060_abnormal_skin_morphology1.40116166
57MP0001188_hyperpigmentation1.38672446
58MP0004381_abnormal_hair_follicle1.36890924
59MP0000467_abnormal_esophagus_morphology1.36863241
60MP0008961_abnormal_basal_metabolism1.36643454
61MP0001270_distended_abdomen1.32386467
62MP0001502_abnormal_circadian_rhythm1.30352349
63MP0003646_muscle_fatigue1.28336743
64* MP0002177_abnormal_outer_ear1.25849176
65MP0004147_increased_porphyrin_level1.25585494
66MP0001835_abnormal_antigen_presentation1.25343517
67MP0000685_abnormal_immune_system1.24752619
68MP0009785_altered_susceptibility_to1.24523075
69* MP0000681_abnormal_thyroid_gland1.24441954
70MP0005375_adipose_tissue_phenotype1.23589268
71MP0003724_increased_susceptibility_to1.22022584
72MP0005623_abnormal_meninges_morphology1.20917257
73MP0003122_maternal_imprinting1.20012367
74MP0003283_abnormal_digestive_organ1.19945609
75MP0000762_abnormal_tongue_morphology1.18932953
76MP0002006_tumorigenesis1.18416691
77MP0000516_abnormal_urinary_system1.18083919
78MP0005367_renal/urinary_system_phenotyp1.18083919
79* MP0002932_abnormal_joint_morphology1.17377816
80MP0003136_yellow_coat_color1.15080517
81MP0009697_abnormal_copulation1.14817542
82MP0003943_abnormal_hepatobiliary_system1.13999843
83MP0000767_abnormal_smooth_muscle1.13797652
84MP0008007_abnormal_cellular_replicative1.11702031
85MP0003111_abnormal_nucleus_morphology1.11278427
86MP0010155_abnormal_intestine_physiology1.11261032
87MP0002108_abnormal_muscle_morphology1.07220653
88MP0009278_abnormal_bone_marrow1.05694379
89MP0002876_abnormal_thyroid_physiology1.05619676
90MP0000383_abnormal_hair_follicle1.03417800
91MP0005503_abnormal_tendon_morphology1.02127075
92MP0000537_abnormal_urethra_morphology1.01730306
93MP0005076_abnormal_cell_differentiation1.00908619
94MP0001348_abnormal_lacrimal_gland1.00775481
95MP0003937_abnormal_limbs/digits/tail_de0.99413794
96* MP0002114_abnormal_axial_skeleton0.98859160
97MP0000733_abnormal_muscle_development0.98518509
98MP0003077_abnormal_cell_cycle0.97630530
99MP0004134_abnormal_chest_morphology0.96993598
100MP0002398_abnormal_bone_marrow0.96658463
101MP0003763_abnormal_thymus_physiology0.94217876
102MP0005275_abnormal_skin_tensile0.93017269
103MP0000534_abnormal_ureter_morphology0.92752394
104MP0002877_abnormal_melanocyte_morpholog0.92609272
105MP0004272_abnormal_basement_membrane0.91610771
106MP0002109_abnormal_limb_morphology0.90783587
107MP0002116_abnormal_craniofacial_bone0.90331923
108MP0009931_abnormal_skin_appearance0.90118852
109MP0000377_abnormal_hair_follicle0.89813325
110* MP0005508_abnormal_skeleton_morphology0.89577680
111MP0000428_abnormal_craniofacial_morphol0.89207694
112MP0003279_aneurysm0.89118764
113MP0005025_abnormal_response_to0.88939681
114MP0002092_abnormal_eye_morphology0.87468235
115MP0002722_abnormal_immune_system0.87437751
116MP0005084_abnormal_gallbladder_morpholo0.86186064
117MP0005360_urolithiasis0.85864664
118MP0001915_intracranial_hemorrhage0.84843622
119MP0010352_gastrointestinal_tract_polyps0.83904942
120MP0005671_abnormal_response_to0.83465349
121MP0008932_abnormal_embryonic_tissue0.82847339
122MP0001216_abnormal_epidermal_layer0.82293018
123MP0003935_abnormal_craniofacial_develop0.81919296
124MP0000689_abnormal_spleen_morphology0.81029657
125MP0005220_abnormal_exocrine_pancreas0.80799368
126MP0003566_abnormal_cell_adhesion0.79682253
127MP0002115_abnormal_skeleton_extremities0.79229798
128MP0002420_abnormal_adaptive_immunity0.78301179
129MP0001919_abnormal_reproductive_system0.77865144
130MP0003938_abnormal_ear_development0.77834512
131MP0006292_abnormal_olfactory_placode0.77270049
132MP0005501_abnormal_skin_physiology0.76776613
133MP0010678_abnormal_skin_adnexa0.76703344
134MP0002452_abnormal_antigen_presenting0.76689426
135MP0002089_abnormal_postnatal_growth/wei0.76189844
136MP0001819_abnormal_immune_cell0.75683060
137* MP0000163_abnormal_cartilage_morphology0.75485020
138* MP0002113_abnormal_skeleton_development0.75437146
139MP0002127_abnormal_cardiovascular_syste0.75387929
140MP0001881_abnormal_mammary_gland0.73921055
141MP0010094_abnormal_chromosome_stability0.73204759
142MP0003119_abnormal_digestive_system0.70942406
143MP0002163_abnormal_gland_morphology0.69992919
144MP0008058_abnormal_DNA_repair0.67962855
145MP0000350_abnormal_cell_proliferation0.67688553
146MP0003755_abnormal_palate_morphology0.66912088
147MP0001145_abnormal_male_reproductive0.66163064
148MP0002135_abnormal_kidney_morphology0.65032617
149MP0003936_abnormal_reproductive_system0.63683892
150MP0002098_abnormal_vibrissa_morphology0.61362401
151MP0000538_abnormal_urinary_bladder0.61277966
152MP0006036_abnormal_mitochondrial_physio0.59998602
153MP0000613_abnormal_salivary_gland0.59692488
154MP0009765_abnormal_xenobiotic_induced0.53684269
155MP0001119_abnormal_female_reproductive0.53339761
156MP0002210_abnormal_sex_determination0.53089102
157MP0000653_abnormal_sex_gland0.52223952
158MP0006276_abnormal_autonomic_nervous0.52174600
159* MP0001664_abnormal_digestion0.52083086
160MP0003948_abnormal_gas_homeostasis0.51993000
161MP0001440_abnormal_grooming_behavior0.51726898

Predicted human phenotypes

RankGene SetZ-score
1Abnormality of cells of the erythroid lineage (HP:0012130)6.17961777
2Abnormal number of erythroid precursors (HP:0012131)5.73600459
3Reticulocytopenia (HP:0001896)5.55237512
4Aplasia/Hypoplasia of the sacrum (HP:0008517)4.41951353
5Thrombocytosis (HP:0001894)4.19450337
6Aplastic anemia (HP:0001915)4.12935070
7Short 1st metacarpal (HP:0010034)4.12894810
8Aplasia/Hypoplasia of the 1st metacarpal (HP:0010026)4.12894810
9Syringomyelia (HP:0003396)4.06878834
10Spinal cord lesions (HP:0100561)4.06878834
11Pallor (HP:0000980)3.72968842
12Rectovaginal fistula (HP:0000143)3.69988805
13Rectal fistula (HP:0100590)3.69988805
14Abnormality of the 1st metacarpal (HP:0010009)3.69201025
15Asymmetry of the thorax (HP:0001555)3.43835952
16Abnormal umbilical cord blood vessels (HP:0011403)3.41795168
17Single umbilical artery (HP:0001195)3.41795168
18Abnormality of the fetal cardiovascular system (HP:0010948)3.41795168
19Intestinal fistula (HP:0100819)3.39255406
20Abnormal lung lobation (HP:0002101)3.27085491
21Abnormal number of incisors (HP:0011064)3.27001700
22Macrocytic anemia (HP:0001972)3.25772966
23Muscle fiber atrophy (HP:0100295)3.22516129
24Abnormality of the distal phalanges of the toes (HP:0010182)3.22374391
25Symphalangism affecting the phalanges of the hand (HP:0009773)3.21058434
26Vaginal fistula (HP:0004320)3.17555223
27Type 2 muscle fiber atrophy (HP:0003554)3.15465452
28Prolonged bleeding time (HP:0003010)3.13866000
29Abnormality of the middle phalanx of the 5th finger (HP:0004219)3.12302246
30Abnormality of the aortic arch (HP:0012303)2.95916692
31Septate vagina (HP:0001153)2.94570383
32Absent phalangeal crease (HP:0006109)2.92897626
33Short phalanx of the thumb (HP:0009660)2.90356944
34Midline defect of the nose (HP:0004122)2.90151259
35Testicular atrophy (HP:0000029)2.90078705
36Abnormality of the middle phalanges of the toes (HP:0010183)2.89172024
37Hyperthyroidism (HP:0000836)2.83365702
38Abnormality of the phalanges of the 5th finger (HP:0004213)2.81715354
39Truncus arteriosus (HP:0001660)2.78501051
40Nonprogressive disorder (HP:0003680)2.78238249
41Microretrognathia (HP:0000308)2.76646841
42Hematochezia (HP:0002573)2.73342710
43Abnormality of the columella (HP:0009929)2.69554356
44Preauricular pit (HP:0004467)2.68384583
45Periauricular skin pits (HP:0100277)2.68384583
46Germ cell neoplasia (HP:0100728)2.67559780
47Broad distal phalanx of finger (HP:0009836)2.67211745
48Bicornuate uterus (HP:0000813)2.66500407
49Optic nerve coloboma (HP:0000588)2.62824132
50Morphological abnormality of the middle ear (HP:0008609)2.56365455
51Down-sloping shoulders (HP:0200021)2.52886369
52Abnormality of the 4th metacarpal (HP:0010012)2.47798170
53Short middle phalanx of the 5th finger (HP:0004220)2.47712379
54Abnormality of the parietal bone (HP:0002696)2.42831465
55Annular pancreas (HP:0001734)2.42688707
56Abnormal connection of the cardiac segments (HP:0011545)2.42345049
57Abnormal ventriculo-arterial connection (HP:0011563)2.42345049
58Transposition of the great arteries (HP:0001669)2.42345049
59Ulnar bowing (HP:0003031)2.39753890
60Ectopic kidney (HP:0000086)2.38741344
61Erythema (HP:0010783)2.35422581
62Aplasia/Hypoplasia of the patella (HP:0006498)2.33326093
63Abnormality of the renal collecting system (HP:0004742)2.32769257
64Acute lymphatic leukemia (HP:0006721)2.31764217
65Methylmalonic aciduria (HP:0012120)2.31228742
66Hypoplasia of the radius (HP:0002984)2.29090574
67Abnormality of the costochondral junction (HP:0000919)2.29020399
68Carpal synostosis (HP:0009702)2.28966361
69Colon cancer (HP:0003003)2.28827987
70Abnormal finger flexion creases (HP:0006143)2.27923363
71Abnormality of the nasal septum (HP:0000419)2.27882091
72Abnormality of the axillary hair (HP:0100134)2.26587099
73Abnormality of secondary sexual hair (HP:0009888)2.26587099
74Protrusio acetabuli (HP:0003179)2.25616019
75IgM deficiency (HP:0002850)2.24854320
76Abnormal hemoglobin (HP:0011902)2.24848007
77Stenosis of the external auditory canal (HP:0000402)2.24506085
78Renal dysplasia (HP:0000110)2.22210193
79Abnormality of the nasal mucosa (HP:0000433)2.20710401
80Weak cry (HP:0001612)2.19769921
81Renal duplication (HP:0000075)2.19287627
82Methylmalonic acidemia (HP:0002912)2.18335825
83Spontaneous hematomas (HP:0007420)2.17167703
84Abnormality of cochlea (HP:0000375)2.16885545
85Absent thumb (HP:0009777)2.16333610
86Short thumb (HP:0009778)2.14908408
87Double outlet right ventricle (HP:0001719)2.14703688
88Congenital malformation of the right heart (HP:0011723)2.14703688
89Elevated erythrocyte sedimentation rate (HP:0003565)2.13707801
90Microcytic anemia (HP:0001935)2.13403270
91Short 5th finger (HP:0009237)2.13314480
92Hypotrichosis (HP:0001006)2.13197148
93Aplasia/Hypoplasia of the phalanges of the thumb (HP:0009658)2.12098905
94Synostosis involving bones of the hand (HP:0004278)2.11823819
95Lip pit (HP:0100267)2.11421591
96Progressive muscle weakness (HP:0003323)2.06267238
97Myositis (HP:0100614)2.03722550
98Patellar aplasia (HP:0006443)2.03510964
99Aplasia/Hypoplasia involving the carpal bones (HP:0006502)2.03157847
100Abnormality of the distal phalanx of the thumb (HP:0009617)2.03133970
101Abnormality of the phalanges of the hallux (HP:0010057)2.02786348
102Type I transferrin isoform profile (HP:0003642)2.00502667
103Abnormality of the heme biosynthetic pathway (HP:0010472)2.00433633
104Bowing of the arm (HP:0006488)2.00241177
105Bowed forearm bones (HP:0003956)2.00241177
106Neonatal short-limb short stature (HP:0008921)1.98323590
107Epistaxis (HP:0000421)1.94657510
108Supernumerary spleens (HP:0009799)1.94413972
109Submucous cleft hard palate (HP:0000176)1.94235000
110Abnormality of the umbilical cord (HP:0010881)1.93231944
111Ureteral stenosis (HP:0000071)1.92742242
112Acute myeloid leukemia (HP:0004808)1.90736669
113Gonadotropin excess (HP:0000837)1.90093531
114Abnormality of the proximal phalanges of the hand (HP:0009834)1.88741631
115Selective tooth agenesis (HP:0001592)1.88416903
116Aplasia/Hypoplasia of the 5th finger (HP:0006262)1.88382241
117Interstitial pulmonary disease (HP:0006530)1.87971523
118Nasolacrimal duct obstruction (HP:0000579)1.87901563
119Partial duplication of the phalanx of hand (HP:0009999)1.86802287
120Aplasia/Hypoplasia of the middle phalanx of the 5th finger (HP:0009161)1.85881772
121Increased muscle lipid content (HP:0009058)1.85648843
122Myotonia (HP:0002486)1.85580479
123Congenital, generalized hypertrichosis (HP:0004540)1.85110062
124Abnormality of DNA repair (HP:0003254)1.85050061
125Chronic otitis media (HP:0000389)1.83743193
126Diastasis recti (HP:0001540)1.82457500
127Increased intramyocellular lipid droplets (HP:0012240)1.81710817
128Absent rod-and cone-mediated responses on ERG (HP:0007688)1.80756854
129Patchy hypopigmentation of hair (HP:0011365)1.80545969
130Migraine (HP:0002076)1.79805912
131Abnormality of the radial head (HP:0003995)1.79725119
132Absent eyebrow (HP:0002223)1.79500553
133Rectal prolapse (HP:0002035)1.79061193
134Dislocated radial head (HP:0003083)1.78887851
135Increased hepatocellular lipid droplets (HP:0006565)1.77923263
136Respiratory difficulties (HP:0002880)1.77405076
137Cutaneous finger syndactyly (HP:0010554)1.77339899
138Delayed cranial suture closure (HP:0000270)1.76807225
139Short hallux (HP:0010109)1.76562093
140Abnormality of the nasolacrimal system (HP:0000614)1.76271804
141Absent eyelashes (HP:0000561)1.75516843
142Proximal placement of thumb (HP:0009623)1.75249796
14311 pairs of ribs (HP:0000878)1.75234512
144Sparse eyelashes (HP:0000653)1.74748982
145Metaphyseal dysplasia (HP:0100255)1.73400948
146Woolly hair (HP:0002224)1.72515412
147Synostosis of carpal bones (HP:0005048)1.70558424
148Birth length less than 3rd percentile (HP:0003561)1.70329894
149Aplasia/Hypoplasia of the 4th metacarpal (HP:0010042)1.70215085
150Short 4th metacarpal (HP:0010044)1.70215085
151Flexion contracture of toe (HP:0005830)1.69805081
152Joint contractures involving the joints of the feet (HP:0100492)1.69805081
153Reduced antithrombin III activity (HP:0001976)1.68887134
154Absent hair (HP:0002298)1.68713008
155Mesangial abnormality (HP:0001966)1.68547983
156Hypoplastic heart (HP:0001961)1.68081628
157Carpal bone hypoplasia (HP:0001498)1.67609416
158Abnormality of reticulocytes (HP:0004312)1.67066168
159Hypoplastic left heart (HP:0004383)1.66849715
160Petechiae (HP:0000967)1.66560872
161Skin pits (HP:0100276)1.66536117
162Abnormality of the lacrimal duct (HP:0011481)1.66385446
163Decreased number of large peripheral myelinated nerve fibers (HP:0003387)1.66384664
164Onycholysis (HP:0001806)1.65577702
165White forelock (HP:0002211)1.63968983
166Abnormality of the 2nd finger (HP:0004100)1.63750008
167Abnormal platelet function (HP:0011869)1.62903955
168Impaired platelet aggregation (HP:0003540)1.62903955
169Hypoproteinemia (HP:0003075)1.62811639
170Peripheral hypomyelination (HP:0007182)1.62595400
171Distal arthrogryposis (HP:0005684)1.61266238
172Abnormality of the phalanges of the 2nd finger (HP:0009541)1.58535460
173Depressed nasal ridge (HP:0000457)1.58190306
174Myelodysplasia (HP:0002863)1.57500244
175Cutaneous melanoma (HP:0012056)1.56640481
176Decreased skull ossification (HP:0004331)1.56187741
177Thick lower lip vermilion (HP:0000179)1.55852429
178Bilateral microphthalmos (HP:0007633)1.55649698
179Radial bowing (HP:0002986)1.54482746
180Decreased activity of cytochrome C oxidase in muscle tissue (HP:0003688)1.53966839
181Pili torti (HP:0003777)1.53382502
182Fragile nails (HP:0001808)1.52219887

Predicted kinase interactions (KEA)

RankGene SetZ-score
1NME23.88585803
2TIE13.75182745
3MKNK13.53370001
4MUSK3.40853215
5MAPK153.39820383
6TGFBR13.28148768
7MKNK22.83365720
8TLK12.80538646
9CDK122.75392085
10MAP3K122.59244755
11TGFBR22.54326248
12KIT2.16841755
13CDC72.11130473
14EEF2K2.08684534
15TNIK1.95793062
16TEC1.91183651
17LRRK21.85334033
18MAPKAPK31.83767867
19FLT31.74264598
20WEE11.72353744
21IRAK31.67584459
22CAMK1G1.63421000
23CDK191.59934050
24MAPKAPK51.59720046
25RPS6KB21.59430626
26SRPK11.58737818
27BTK1.58637168
28BRD41.58013942
29ABL21.57467505
30CHEK21.56122078
31AKT31.53366633
32STK161.53212709
33MAP4K11.43262512
34ERBB31.41954949
35RPS6KA41.40266573
36AURKA1.39858157
37ILK1.39243892
38ICK1.38940706
39WNK41.32382954
40TRPM71.31857872
41EPHB21.31048297
42TAOK31.30928435
43GRK61.30653418
44BLK1.29292671
45DYRK31.27925673
46RPS6KA61.27825427
47GRK11.23869886
48SMG11.23561705
49MAP3K61.20623838
50RPS6KC11.20314237
51RPS6KL11.20314237
52RPS6KA21.18881609
53NLK1.14231420
54PRKG21.12886157
55BRSK21.12591838
56TNK21.11538368
57CDK81.11346107
58KDR1.10315129
59MAPK111.09625980
60LIMK11.06577200
61MTOR1.05392784
62CSNK1G11.04402484
63MAP3K111.03777124
64PKN21.03242164
65CAMK1D1.02565266
66VRK20.99978457
67ARAF0.97586811
68CHEK10.95229963
69CLK10.94309971
70IRAK20.93655365
71CSF1R0.93378482
72MATK0.91587961
73PIM10.91373766
74MYLK0.89843042
75AKT20.89323992
76CDK70.88832431
77BRAF0.85881836
78RPS6KA50.84081482
79VRK10.84073023
80PAK40.80162125
81CDK20.80102739
82PNCK0.80000180
83ZAP700.77747275
84PIM20.77418449
85PRKD30.75037084
86CSNK1G30.74116358
87HIPK20.73423779
88TRIB30.73184314
89ACVR1B0.73074215
90IKBKB0.72982563
91PASK0.72592623
92DYRK1B0.72157173
93RPS6KA10.72015360
94TBK10.71292466
95SIK20.69916657
96MAP2K30.68029959
97PDK20.67752668
98MAPK40.64997237
99DYRK20.63485245
100CSNK1A1L0.59085341
101IKBKE0.59065089
102EIF2AK20.57722623
103PAK20.57353300
104MAPK30.56669743
105PTK60.52983203
106ERN10.52419513
107STK100.51942745
108BUB10.51593983
109CDK90.51132949
110PDPK10.51090320
111SIK10.50913145
112BMPR1B0.50589266
113ATM0.50524576
114MAPK140.50151425
115IRAK40.49947363
116PHKG10.49663863
117PHKG20.49663863
118MAP3K100.49442376
119NEK90.49138610
120CDK60.49128834
121RPS6KB10.48697916
122SYK0.48428608
123MAP2K60.47634320
124TESK10.47598685
125FER0.47295174
126PRKD20.45165958
127CSNK1G20.45114705
128MAPK80.44727593
129AKT10.44100545
130ADRBK10.43756703
131PRKAA10.43694575
132CAMK10.43440960
133CDK40.43065091
134MAP2K10.42808322
135FES0.42553431
136GSK3B0.41988639
137FGFR30.41640530
138CHUK0.41049300
139CDK10.40132067
140LYN0.39963332
141MAP2K40.39843344
142EPHA30.39499461
143BCKDK0.38985432
144CASK0.38843298
145CSNK2A10.38548625
146MAP2K20.37520332
147TXK0.37043586
148NEK20.36077628
149FRK0.35408420
150MAP3K70.34954171
151MAPKAPK20.34586275
152RIPK10.34084375
153AURKB0.33518416
154CDK30.33293313
155MST40.30961254
156ATR0.30251046

Predicted pathways (KEGG)

RankGene SetZ-score
1Ribosome_Homo sapiens_hsa030107.37672689
2Butirosin and neomycin biosynthesis_Homo sapiens_hsa005243.40332413
3Sulfur metabolism_Homo sapiens_hsa009202.93160666
4DNA replication_Homo sapiens_hsa030302.73694711
5Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005632.46392027
6Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005332.44454945
7Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate_Homo sapiens_hsa005322.40167359
8Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001302.32379654
9Spliceosome_Homo sapiens_hsa030402.24960586
10One carbon pool by folate_Homo sapiens_hsa006702.07819389
11Base excision repair_Homo sapiens_hsa034102.05606955
12Transcriptional misregulation in cancer_Homo sapiens_hsa052022.02187308
13Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa005342.01327545
14Cyanoamino acid metabolism_Homo sapiens_hsa004601.92314199
15Cytosolic DNA-sensing pathway_Homo sapiens_hsa046231.82764455
16Renin-angiotensin system_Homo sapiens_hsa046141.80034036
17Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006011.77671324
18Selenocompound metabolism_Homo sapiens_hsa004501.76230006
19Platelet activation_Homo sapiens_hsa046111.58359592
20Thyroid cancer_Homo sapiens_hsa052161.51528719
21Pyrimidine metabolism_Homo sapiens_hsa002401.49343710
22Caffeine metabolism_Homo sapiens_hsa002321.49234360
23Glycosaminoglycan degradation_Homo sapiens_hsa005311.48029527
24Inflammatory bowel disease (IBD)_Homo sapiens_hsa053211.40434891
25RIG-I-like receptor signaling pathway_Homo sapiens_hsa046221.35532836
26p53 signaling pathway_Homo sapiens_hsa041151.29471852
27Herpes simplex infection_Homo sapiens_hsa051681.27950816
28Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005121.27076858
29Mismatch repair_Homo sapiens_hsa034301.26429206
30RNA degradation_Homo sapiens_hsa030181.24821650
31RNA polymerase_Homo sapiens_hsa030201.21754034
32Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006301.21504420
33Cell cycle_Homo sapiens_hsa041101.20964837
34Jak-STAT signaling pathway_Homo sapiens_hsa046301.17577058
35Small cell lung cancer_Homo sapiens_hsa052221.17103462
36Basal cell carcinoma_Homo sapiens_hsa052171.15980762
37Glycerolipid metabolism_Homo sapiens_hsa005611.13632182
38Vitamin digestion and absorption_Homo sapiens_hsa049771.13066188
39Fat digestion and absorption_Homo sapiens_hsa049751.11959625
40Acute myeloid leukemia_Homo sapiens_hsa052211.08597626
41Hematopoietic cell lineage_Homo sapiens_hsa046401.06711512
42N-Glycan biosynthesis_Homo sapiens_hsa005101.06667755
43Leishmaniasis_Homo sapiens_hsa051401.06416380
44Steroid hormone biosynthesis_Homo sapiens_hsa001401.06326792
45Nucleotide excision repair_Homo sapiens_hsa034201.05976196
46Longevity regulating pathway - mammal_Homo sapiens_hsa042111.05319879
47Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007601.01662048
48Cytokine-cytokine receptor interaction_Homo sapiens_hsa040600.99982838
49Asthma_Homo sapiens_hsa053100.92570997
50Other glycan degradation_Homo sapiens_hsa005110.91228869
51Maturity onset diabetes of the young_Homo sapiens_hsa049500.90697827
52Primary immunodeficiency_Homo sapiens_hsa053400.90624311
53Homologous recombination_Homo sapiens_hsa034400.90589636
54SNARE interactions in vesicular transport_Homo sapiens_hsa041300.89930708
55Lysine degradation_Homo sapiens_hsa003100.89256838
56Pathogenic Escherichia coli infection_Homo sapiens_hsa051300.89008189
57Pertussis_Homo sapiens_hsa051330.88281299
58Chronic myeloid leukemia_Homo sapiens_hsa052200.88123995
59NOD-like receptor signaling pathway_Homo sapiens_hsa046210.87139385
60Measles_Homo sapiens_hsa051620.87052955
61Amyotrophic lateral sclerosis (ALS)_Homo sapiens_hsa050140.86695248
62Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008600.86099678
63Shigellosis_Homo sapiens_hsa051310.85573699
64RNA transport_Homo sapiens_hsa030130.82926089
65Antigen processing and presentation_Homo sapiens_hsa046120.81619548
66AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa049330.81112645
67Leukocyte transendothelial migration_Homo sapiens_hsa046700.81074048
68Pathways in cancer_Homo sapiens_hsa052000.79411657
69B cell receptor signaling pathway_Homo sapiens_hsa046620.79079418
70Proteasome_Homo sapiens_hsa030500.79017603
71HTLV-I infection_Homo sapiens_hsa051660.78607617
72Adipocytokine signaling pathway_Homo sapiens_hsa049200.77532205
73Hepatitis B_Homo sapiens_hsa051610.77152085
74Fanconi anemia pathway_Homo sapiens_hsa034600.77017859
75Protein export_Homo sapiens_hsa030600.76793816
76ECM-receptor interaction_Homo sapiens_hsa045120.74651805
77Purine metabolism_Homo sapiens_hsa002300.73212277
78mRNA surveillance pathway_Homo sapiens_hsa030150.73130144
79Longevity regulating pathway - multiple species_Homo sapiens_hsa042130.72603373
80Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030080.72183301
81Galactose metabolism_Homo sapiens_hsa000520.71941915
82Toll-like receptor signaling pathway_Homo sapiens_hsa046200.71346918
83Drug metabolism - other enzymes_Homo sapiens_hsa009830.71346099
84Legionellosis_Homo sapiens_hsa051340.70164234
85Salmonella infection_Homo sapiens_hsa051320.70015569
86Basal transcription factors_Homo sapiens_hsa030220.69712470
87Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa045500.69665771
88Hedgehog signaling pathway_Homo sapiens_hsa043400.68668701
89Proteoglycans in cancer_Homo sapiens_hsa052050.68327299
90Arachidonic acid metabolism_Homo sapiens_hsa005900.67181304
91PI3K-Akt signaling pathway_Homo sapiens_hsa041510.66284195
92TGF-beta signaling pathway_Homo sapiens_hsa043500.64767013
93Pentose phosphate pathway_Homo sapiens_hsa000300.63794939
94Ovarian steroidogenesis_Homo sapiens_hsa049130.63788280
95Systemic lupus erythematosus_Homo sapiens_hsa053220.62635893
96Chagas disease (American trypanosomiasis)_Homo sapiens_hsa051420.62375855
97Chemical carcinogenesis_Homo sapiens_hsa052040.62296514
98MicroRNAs in cancer_Homo sapiens_hsa052060.60972671
99mTOR signaling pathway_Homo sapiens_hsa041500.60512345
100Malaria_Homo sapiens_hsa051440.59965131
101NF-kappa B signaling pathway_Homo sapiens_hsa040640.58283170
102Intestinal immune network for IgA production_Homo sapiens_hsa046720.57006521
103Notch signaling pathway_Homo sapiens_hsa043300.57003889
104Other types of O-glycan biosynthesis_Homo sapiens_hsa005140.55213721
105Toxoplasmosis_Homo sapiens_hsa051450.54988320
106Hippo signaling pathway_Homo sapiens_hsa043900.54503944
107Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006040.54491633
108Parkinsons disease_Homo sapiens_hsa050120.53999157
109Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006030.53042420
110Bacterial invasion of epithelial cells_Homo sapiens_hsa051000.52573775
111Rap1 signaling pathway_Homo sapiens_hsa040150.52298046
112Fc epsilon RI signaling pathway_Homo sapiens_hsa046640.51991853
113Ubiquitin mediated proteolysis_Homo sapiens_hsa041200.51578242
114Phototransduction_Homo sapiens_hsa047440.51370424
115Non-small cell lung cancer_Homo sapiens_hsa052230.51070503
116Influenza A_Homo sapiens_hsa051640.50496684
117AMPK signaling pathway_Homo sapiens_hsa041520.50432583
118Bladder cancer_Homo sapiens_hsa052190.49360469
119Hepatitis C_Homo sapiens_hsa051600.48975706
120Neurotrophin signaling pathway_Homo sapiens_hsa047220.48912574
121Sulfur relay system_Homo sapiens_hsa041220.46235989
122Neuroactive ligand-receptor interaction_Homo sapiens_hsa040800.45877243
123Melanoma_Homo sapiens_hsa052180.45133115
124Focal adhesion_Homo sapiens_hsa045100.44324318
125Wnt signaling pathway_Homo sapiens_hsa043100.44085642
126Melanogenesis_Homo sapiens_hsa049160.43556277
127Metabolic pathways_Homo sapiens_hsa011000.42991623
128Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049320.42875222
129Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa009700.42769640
130TNF signaling pathway_Homo sapiens_hsa046680.42310455
131alpha-Linolenic acid metabolism_Homo sapiens_hsa005920.42154427
132Choline metabolism in cancer_Homo sapiens_hsa052310.41002128
133Folate biosynthesis_Homo sapiens_hsa007900.40650964
134Retinol metabolism_Homo sapiens_hsa008300.40060582
135Type II diabetes mellitus_Homo sapiens_hsa049300.39932840
136Apoptosis_Homo sapiens_hsa042100.38267808
137Circadian rhythm_Homo sapiens_hsa047100.38189373
138HIF-1 signaling pathway_Homo sapiens_hsa040660.37710435
139Osteoclast differentiation_Homo sapiens_hsa043800.37688946
140Natural killer cell mediated cytotoxicity_Homo sapiens_hsa046500.37685818
141Pentose and glucuronate interconversions_Homo sapiens_hsa000400.36957276
142MAPK signaling pathway_Homo sapiens_hsa040100.36187815
143Regulation of lipolysis in adipocytes_Homo sapiens_hsa049230.35210690
144Nitrogen metabolism_Homo sapiens_hsa009100.34713324
145Huntingtons disease_Homo sapiens_hsa050160.34522481
146Aldosterone synthesis and secretion_Homo sapiens_hsa049250.32188868
147Glycerophospholipid metabolism_Homo sapiens_hsa005640.30927256
148Cysteine and methionine metabolism_Homo sapiens_hsa002700.29870420
149Cholinergic synapse_Homo sapiens_hsa047250.29499337
150Linoleic acid metabolism_Homo sapiens_hsa005910.29352715
151Peroxisome_Homo sapiens_hsa041460.26411693
152Valine, leucine and isoleucine degradation_Homo sapiens_hsa002800.25015025
153Protein digestion and absorption_Homo sapiens_hsa049740.24356279

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