HOXA6

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: In vertebrates, the genes encoding the class of transcription factors called homeobox genes are found in clusters named A, B, C, and D on four separate chromosomes. Expression of these proteins is spatially and temporally regulated during embryonic development. This gene is part of the A cluster on chromosome 7 and encodes a DNA-binding transcription factor which may regulate gene expression, morphogenesis, and differentiation. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1thyroid gland development (GO:0030878)7.11318553
2definitive hemopoiesis (GO:0060216)6.44485091
3dosage compensation (GO:0007549)6.21905218
4ribosomal small subunit assembly (GO:0000028)5.77588968
5cranial nerve morphogenesis (GO:0021602)5.60670758
6respiratory tube development (GO:0030323)5.50252146
7amyloid precursor protein catabolic process (GO:0042987)5.39027382
8mammary gland epithelial cell differentiation (GO:0060644)5.01821840
9positive regulation of receptor biosynthetic process (GO:0010870)4.90042278
10embryonic heart tube development (GO:0035050)4.85660070
11viral transcription (GO:0019083)4.56409868
12cartilage morphogenesis (GO:0060536)4.41577252
13ribosomal small subunit biogenesis (GO:0042274)4.41096413
14antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-independent (G4.40839688
15lymph vessel development (GO:0001945)4.36283888
16translational termination (GO:0006415)4.35377741
17megakaryocyte development (GO:0035855)4.19318581
18Peyers patch development (GO:0048541)4.18327884
19mucosal-associated lymphoid tissue development (GO:0048537)4.18327884
20mature B cell differentiation involved in immune response (GO:0002313)4.17488474
21positive regulation of histone deacetylation (GO:0031065)4.13398905
22hepatocyte apoptotic process (GO:0097284)4.08627695
23cellular extravasation (GO:0045123)4.01760334
24negative regulation of cell cycle G2/M phase transition (GO:1902750)3.94719639
25negative regulation of erythrocyte differentiation (GO:0045647)3.91134790
26nuclear-transcribed mRNA catabolic process, nonsense-mediated decay (GO:0000184)3.87838736
27regulation of single stranded viral RNA replication via double stranded DNA intermediate (GO:00450913.84631875
28deoxyribonucleoside monophosphate metabolic process (GO:0009162)3.81650002
29mammary gland alveolus development (GO:0060749)3.81549444
30regulation of DNA damage checkpoint (GO:2000001)3.74832994
31rRNA catabolic process (GO:0016075)3.73819635
32translational elongation (GO:0006414)3.73193618
33negative regulation of B cell apoptotic process (GO:0002903)3.65893496
34regulation of mammary gland epithelial cell proliferation (GO:0033599)3.62661345
35peripheral nervous system neuron development (GO:0048935)3.61185077
36negative regulation of mRNA splicing, via spliceosome (GO:0048025)3.60023192
37pyrimidine deoxyribonucleotide catabolic process (GO:0009223)3.57454716
38formation of translation preinitiation complex (GO:0001731)3.56745879
39lung secretory cell differentiation (GO:0061140)3.55230727
40antigen processing and presentation via MHC class Ib (GO:0002475)3.51079791
41pyrimidine nucleoside monophosphate metabolic process (GO:0009129)3.49183963
42viral life cycle (GO:0019058)3.45522947
43amyloid precursor protein metabolic process (GO:0042982)3.44157784
44angiogenesis involved in wound healing (GO:0060055)3.43623109
45SRP-dependent cotranslational protein targeting to membrane (GO:0006614)3.43087952
46cotranslational protein targeting to membrane (GO:0006613)3.36113603
47protein targeting to ER (GO:0045047)3.35191830
48negative regulation of DNA repair (GO:0045738)3.33746198
49autophagic vacuole fusion (GO:0000046)3.31109030
50respiratory system process (GO:0003016)3.29864939
51germ cell migration (GO:0008354)3.28512311
52mRNA stabilization (GO:0048255)3.23880503
53RNA stabilization (GO:0043489)3.23880503
54positive regulation of protein deacetylation (GO:0090312)3.21664057
55establishment of protein localization to endoplasmic reticulum (GO:0072599)3.21382813
56protein localization to cell surface (GO:0034394)3.20191644
57regulation of apoptotic process involved in morphogenesis (GO:1902337)3.17685058
58proximal/distal pattern formation (GO:0009954)3.17340625
59cellular protein complex disassembly (GO:0043624)3.16208323
60* skeletal system morphogenesis (GO:0048705)3.16108304
61negative regulation of fibroblast apoptotic process (GO:2000270)3.15665459
62heparin biosynthetic process (GO:0030210)3.14903508
63heparin metabolic process (GO:0030202)3.14903508
64blood vessel maturation (GO:0001955)3.13416489
65epithelial cell maturation (GO:0002070)3.13224075
66growth hormone receptor signaling pathway (GO:0060396)3.11428625
67aggressive behavior (GO:0002118)3.09851245
68negative regulation of mRNA processing (GO:0050686)3.09367892
69vascular endothelial growth factor signaling pathway (GO:0038084)3.09265932
70UV protection (GO:0009650)3.07372586
71translational initiation (GO:0006413)3.06882058
72negative regulation of epidermis development (GO:0045683)3.04955881
73nucleotide salvage (GO:0043173)3.04694906
74grooming behavior (GO:0007625)3.04653791
75peptidyl-arginine omega-N-methylation (GO:0035247)3.02617332
76DNA unwinding involved in DNA replication (GO:0006268)3.01189135
77rRNA transcription (GO:0009303)3.00824961
78protein localization to endoplasmic reticulum (GO:0070972)3.00586256
79embryonic skeletal joint morphogenesis (GO:0060272)3.00435829
80insulin-like growth factor receptor signaling pathway (GO:0048009)3.00097079
81DNA replication initiation (GO:0006270)2.99857536
82positive regulation of blood vessel endothelial cell migration (GO:0043536)2.99362076
83regulation of centriole replication (GO:0046599)2.99028497
84mature B cell differentiation (GO:0002335)2.96469845
85mesenchymal-epithelial cell signaling (GO:0060638)2.96255276
863-UTR-mediated mRNA stabilization (GO:0070935)2.95342549
87pyrimidine nucleoside monophosphate biosynthetic process (GO:0009130)2.94973229
88regulation of histone H3-K4 methylation (GO:0051569)2.94819577
89regulation of translational fidelity (GO:0006450)2.93886609
90protein complex disassembly (GO:0043241)2.93636485
91viral mRNA export from host cell nucleus (GO:0046784)2.92184721
92DNA strand elongation involved in DNA replication (GO:0006271)2.92182928
93vitamin A metabolic process (GO:0006776)2.90123412
94lymphoid progenitor cell differentiation (GO:0002320)2.89798286
95protein localization to kinetochore (GO:0034501)2.89043825
96* anterior/posterior pattern specification (GO:0009952)2.88331445
97regulation of hydrogen peroxide metabolic process (GO:0010310)2.87947382
98telomere maintenance via semi-conservative replication (GO:0032201)2.83811349
99positive regulation of mitochondrial membrane permeability (GO:0035794)2.83809620
100chromatin assembly (GO:0031497)2.82608630
101negative regulation of myeloid cell differentiation (GO:0045638)2.82132279
102primitive streak formation (GO:0090009)2.81747135
103macroautophagy (GO:0016236)2.81746269
104maturation of SSU-rRNA (GO:0030490)2.80039390
105nuclear-transcribed mRNA catabolic process (GO:0000956)2.79818875
106regulation of female receptivity (GO:0045924)2.79771388
107negative regulation of phagocytosis (GO:0050765)2.79319570
108negative regulation of defense response to virus (GO:0050687)2.78557367
109pyrimidine nucleotide catabolic process (GO:0006244)2.77785238
110pseudouridine synthesis (GO:0001522)2.76954490
111DNA strand elongation (GO:0022616)2.76903757
112* embryonic organ morphogenesis (GO:0048562)2.75708714
113T cell apoptotic process (GO:0070231)2.75481682
114macromolecular complex disassembly (GO:0032984)2.75429502
115mitochondrial outer membrane permeabilization involved in programmed cell death (GO:1902686)2.74022932
116positive regulation of mitochondrial membrane permeability involved in apoptotic process (GO:19021102.74022932
117folic acid metabolic process (GO:0046655)2.73863640
118methionine biosynthetic process (GO:0009086)2.73408226
119embryonic hemopoiesis (GO:0035162)2.72713955
120maternal placenta development (GO:0001893)2.72355844
121AMP metabolic process (GO:0046033)2.71810032
122histone H3-K36 demethylation (GO:0070544)2.70525314
123peptidyl-arginine methylation (GO:0018216)2.70103803
124peptidyl-arginine N-methylation (GO:0035246)2.70103803
125negative regulation of vascular endothelial growth factor receptor signaling pathway (GO:0030948)2.69940453
126* embryonic skeletal system morphogenesis (GO:0048704)2.68097668
127negative regulation of cell cycle arrest (GO:0071157)2.67696908
128organ induction (GO:0001759)2.67457578
129morphogenesis of an endothelium (GO:0003159)2.67230903
130endothelial tube morphogenesis (GO:0061154)2.67230903
131folic acid-containing compound biosynthetic process (GO:0009396)2.66461722
132negative regulation of Notch signaling pathway (GO:0045746)2.66200861
133mast cell degranulation (GO:0043303)2.65844943
134mast cell activation involved in immune response (GO:0002279)2.65844943
135positive regulation of DNA repair (GO:0045739)2.65705565
136mRNA catabolic process (GO:0006402)2.65490285
137regulation of stem cell maintenance (GO:2000036)2.65004512
138microtubule severing (GO:0051013)2.63860351
139interleukin-1-mediated signaling pathway (GO:0070498)2.63620693
140embryonic viscerocranium morphogenesis (GO:0048703)2.62716141
141phospholipase C-activating dopamine receptor signaling pathway (GO:0060158)2.61739535
142positive regulation of DNA-dependent DNA replication (GO:2000105)2.60804978
143platelet dense granule organization (GO:0060155)2.59079579
144positive regulation of prostaglandin secretion (GO:0032308)2.58980794
145DNA dealkylation (GO:0035510)2.58680137
146histone H2A acetylation (GO:0043968)2.58521191
147heterochromatin organization (GO:0070828)2.58373893
148chondrocyte proliferation (GO:0035988)2.57605200
149negative regulation of response to biotic stimulus (GO:0002832)2.57170673
150deoxyribonucleotide catabolic process (GO:0009264)2.56756019
151negative regulation of cell size (GO:0045792)2.56639645
152lymphocyte apoptotic process (GO:0070227)2.56227967
153positive regulation of histone H3-K4 methylation (GO:0051571)2.56134856
154cellular response to growth hormone stimulus (GO:0071378)2.56085363
155uterus development (GO:0060065)2.53950216
156regulation of monocyte differentiation (GO:0045655)2.53834191
157translesion synthesis (GO:0019985)2.53677868
158ubiquinone biosynthetic process (GO:0006744)2.53145936
159negative regulation of RNA splicing (GO:0033119)2.52564670
160peptidyl-histidine modification (GO:0018202)2.51596325
161negative regulation of granulocyte differentiation (GO:0030853)2.51574921
162poly(A)+ mRNA export from nucleus (GO:0016973)2.51218676
163cartilage development involved in endochondral bone morphogenesis (GO:0060351)2.50812419
164lung-associated mesenchyme development (GO:0060484)2.50724502
165negative regulation of macroautophagy (GO:0016242)2.50717126
166RNA catabolic process (GO:0006401)2.50592840
167DNA synthesis involved in DNA repair (GO:0000731)2.50069536
168alternative mRNA splicing, via spliceosome (GO:0000380)2.49910695
169negative regulation of homotypic cell-cell adhesion (GO:0034111)2.48801489
170negative regulation of phosphatidylinositol 3-kinase signaling (GO:0014067)2.48476380
171cell proliferation involved in metanephros development (GO:0072203)2.48345461
172organelle membrane fusion (GO:0090174)2.47164825
173cellular response to vascular endothelial growth factor stimulus (GO:0035924)2.46785501
174nucleotide-excision repair, DNA gap filling (GO:0006297)2.46510590
175transcription from mitochondrial promoter (GO:0006390)2.46486797
176protein targeting to membrane (GO:0006612)2.46043441
177deoxyribose phosphate catabolic process (GO:0046386)2.45333308
178spliceosomal tri-snRNP complex assembly (GO:0000244)2.45306987
179seminiferous tubule development (GO:0072520)2.45282273
180negative regulation of necroptotic process (GO:0060546)2.45270200
181negative regulation of histone methylation (GO:0031061)2.44563221
182sleep (GO:0030431)2.44090905
183snRNA metabolic process (GO:0016073)2.44078009
184negative regulation of mRNA metabolic process (GO:1903312)2.43059132
185DNA biosynthetic process (GO:0071897)2.43020868
186ADP metabolic process (GO:0046031)2.42254078
187phosphatidylglycerol biosynthetic process (GO:0006655)2.41200223

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse5.64185682
2SCL_19346495_ChIP-Seq_HPC-7_Human3.93626988
3BP1_19119308_ChIP-ChIP_Hs578T_Human3.69623993
4FOXM1_23109430_ChIP-Seq_U2OS_Human3.26613314
5MYC_22102868_ChIP-Seq_BL_Human3.21668753
6E2F7_22180533_ChIP-Seq_HELA_Human3.14877801
7TP63_19390658_ChIP-ChIP_HaCaT_Human2.95399597
8EGR1_19374776_ChIP-ChIP_THP-1_Human2.95057797
9VDR_21846776_ChIP-Seq_THP-1_Human2.81410811
10EKLF_21900194_ChIP-Seq_ERYTHROCYTE_Mouse2.75015139
11KDM5A_27292631_Chip-Seq_BREAST_Human2.51654390
12FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse2.47537984
13TP63_17297297_ChIP-ChIP_HaCaT_Human2.46715243
14MYC_18555785_ChIP-Seq_MESCs_Mouse2.34468093
15HCFC1_20581084_ChIP-Seq_MESCs_Mouse2.34184425
16TCF7_22412390_ChIP-Seq_EML_Mouse2.29624687
17NUCKS1_24931609_ChIP-Seq_HEPATOCYTES_Mouse2.29506123
18* CHD7_19251738_ChIP-ChIP_MESCs_Mouse2.28201491
19JARID1A_20064375_ChIP-Seq_MESCs_Mouse2.22270683
20ESR1_20079471_ChIP-ChIP_T-47D_Human2.21132386
21* ELK3_25401928_ChIP-Seq_HUVEC_Human2.11927023
22MECOM_23826213_ChIP-Seq_KASUMI_Mouse2.09120834
23KLF4_18264089_ChIP-ChIP_MESCs_Mouse2.04453051
24KLF2_18264089_ChIP-ChIP_MESCs_Mouse2.04453051
25KLF5_18264089_ChIP-ChIP_MESCs_Mouse2.04453051
26* TTF2_22483619_ChIP-Seq_HELA_Human1.99017132
27GATA1_22025678_ChIP-Seq_K562_Human1.98243632
28CTNNB1_20615089_ChIP-ChIP_FETAL_BRAIN_Human1.98181677
29ETS1_20019798_ChIP-Seq_JURKAT_Human1.95943077
30BCL3_23251550_ChIP-Seq_MUSCLE_Mouse1.95278345
31MYB_21317192_ChIP-Seq_ERMYB_Mouse1.93873129
32ELF1_20517297_ChIP-Seq_JURKAT_Human1.88184148
33RUNX1_20887958_ChIP-Seq_HPC-7_Mouse1.87554631
34ELF1_17652178_ChIP-ChIP_JURKAT_Human1.81190971
35KDM2B_26808549_Chip-Seq_SIL-ALL_Human1.80179179
36STAT6_21828071_ChIP-Seq_BEAS2B_Human1.79480709
37FOXM1_25889361_ChIP-Seq_OE33_AND_U2OS_Human1.79456189
38* WT1_20215353_ChIP-ChIP_NEPHRON_PROGENITOR_Mouse1.76907074
39THAP11_20581084_ChIP-Seq_MESCs_Mouse1.71221154
40RUNX2_24764292_ChIP-Seq_MC3T3_Mouse1.66522531
41PRDM16_22522345_ChIP-ChIP_PALATE_MESENCHYMAL_Mouse1.63677905
42FOXP3_21729870_ChIP-Seq_TREG_Human1.63402995
43E2F1_21310950_ChIP-Seq_MCF-7_Human1.61642980
44VDR_24763502_ChIP-Seq_THP-1_Human1.61504666
45DACH1_20351289_ChIP-Seq_MDA-MB-231_Human1.61123363
46RARG_19884340_ChIP-ChIP_MEFs_Mouse1.61090540
47ESR1_15608294_ChIP-ChIP_MCF-7_Human1.60991870
48HIF1A_21447827_ChIP-Seq_MCF-7_Human1.60062604
49MYC_19079543_ChIP-ChIP_MESCs_Mouse1.59968480
50TAL1_20887958_ChIP-Seq_HPC-7_Mouse1.59454399
51GABP_19822575_ChIP-Seq_HepG2_Human1.56908858
52KDM2B_26808549_Chip-Seq_SUP-B15_Human1.56634591
53PKCTHETA_26484144_Chip-Seq_BREAST_Human1.55965627
54SPI1_22790984_ChIP-Seq_ERYTHROLEUKEMIA_Mouse1.55343803
55DCP1A_22483619_ChIP-Seq_HELA_Human1.55332343
56MAF_26560356_Chip-Seq_TH1_Human1.49901333
57P68_20966046_ChIP-Seq_HELA_Human1.46763462
58CLOCK_20551151_ChIP-Seq_293T_Human1.46022705
59E2F4_21247883_ChIP-Seq_LYMPHOBLASTOID_Human1.45919693
60VDR_23849224_ChIP-Seq_CD4+_Human1.44614676
61* TET1_21451524_ChIP-Seq_MESCs_Mouse1.41095370
62YY1_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse1.40728741
63RUNX1_22412390_ChIP-Seq_EML_Mouse1.39352042
64E2F4_17652178_ChIP-ChIP_JURKAT_Human1.38895328
65KDM2B_26808549_Chip-Seq_HPB-ALL_Human1.37222984
66RUNX_20019798_ChIP-Seq_JUKART_Human1.35460852
67KDM2B_26808549_Chip-Seq_DND41_Human1.35418418
68SFPI1_20887958_ChIP-Seq_HPC-7_Mouse1.35325335
69MAF_26560356_Chip-Seq_TH2_Human1.34607579
70FOXP3_17237761_ChIP-ChIP_TREG_Mouse1.34294582
71UTX_26944678_Chip-Seq_JUKART_Human1.32742315
72KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human1.32060722
73KLF4_18358816_ChIP-ChIP_MESCs_Mouse1.31926716
74IRF8_22096565_ChIP-ChIP_GC-B_Human1.31334750
75CREB1_23762244_ChIP-Seq_HIPPOCAMPUS_Rat1.31139196
76* TBP_23326641_ChIP-Seq_C3H10T1-2_Mouse1.30923859
77IGF1R_20145208_ChIP-Seq_DFB_Human1.30474787
78CBX2_27304074_Chip-Seq_ESCs_Mouse1.29356900
79ZFP281_18757296_ChIP-ChIP_E14_Mouse1.28067065
80CIITA_25753668_ChIP-Seq_RAJI_Human1.27494152
81ZNF652_21678463_ChIP-ChIP_ZR75-1_Human1.26901887
82* PHC1_16625203_ChIP-ChIP_MESCs_Mouse1.26091691
83GFI1B_20887958_ChIP-Seq_HPC-7_Mouse1.25353129
84NOTCH1_17114293_ChIP-ChIP_T-ALL_Human1.23940817
85CTCF_21964334_ChIP-Seq_BJAB-B_Human1.23242736
86CTCF_27219007_Chip-Seq_ERYTHROID_Human1.22383214
87EST1_17652178_ChIP-ChIP_JURKAT_Human1.21864406
88NCOR1_26117541_ChIP-Seq_K562_Human1.21769350
89NOTCH1_21737748_ChIP-Seq_TLL_Human1.21175129
90POU5F1_18700969_ChIP-ChIP_MESCs_Mouse1.20910657
91CDX2_20551321_ChIP-Seq_CACO-2_Human1.20205167
92ASXL1_24218140_ChIP-Seq_BMDM_Mouse1.20058677
93IRF1_21803131_ChIP-Seq_MONOCYTES_Human1.19271784
94ZFP42_18358816_ChIP-ChIP_MESCs_Mouse1.18248456
95TCF3_18692474_ChIP-Seq_MEFs_Mouse1.18247656
96* BCL6_27268052_Chip-Seq_Bcells_Human1.17640586
97SPI1_23547873_ChIP-Seq_NB4_Human1.17414654
98MYC_18940864_ChIP-ChIP_HL60_Human1.16155694
99PPARG_19300518_ChIP-PET_3T3-L1_Mouse1.16089255
100GATA2_21666600_ChIP-Seq_HMVEC_Human1.15982324
101TFEB_21752829_ChIP-Seq_HELA_Human1.15638584
102DMRT1_23473982_ChIP-Seq_TESTES_Mouse1.14707196
103P300_27058665_Chip-Seq_ZR-75-30cells_Human1.14441928
104PHF8_20622854_ChIP-Seq_HELA_Human1.13759346
105ZFP281_27345836_Chip-Seq_ESCs_Mouse1.13269289
106E2A_27217539_Chip-Seq_RAMOS-Cell_line_Human1.13061883
107WT1_19549856_ChIP-ChIP_CCG9911_Human1.12431834
108POU5F1_18555785_ChIP-Seq_MESCs_Mouse1.12283605
109STAT3_22323479_ChIP-Seq_MACROPHAGE_Mouse1.12045275
110XRN2_22483619_ChIP-Seq_HELA_Human1.11947540
111HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human1.10867422
112NR1H3_23393188_ChIP-Seq_ATHEROSCLEROTIC-FOAM_Human1.10202579
113TCF21_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human1.09910064
114MYBL1_21750041_ChIP-ChIP_SPERMATOCYTES_Mouse1.09774153
115ZFX_18555785_ChIP-Seq_MESCs_Mouse1.08438513
116* SMAD3_18955504_ChIP-ChIP_HaCaT_Human1.07723327
117* SMAD2_18955504_ChIP-ChIP_HaCaT_Human1.07723327
118* TP53_20018659_ChIP-ChIP_R1E_Mouse1.07168013
119KLF6_26769127_Chip-Seq_PDAC-Cell_line_Human1.06830255
120ZFP281_18358816_ChIP-ChIP_MESCs_Mouse1.05847824
121CEBPB_21427703_ChIP-Seq_3T3-L1_Mouse1.05677073
122MYB_26560356_Chip-Seq_TH1_Human1.05331265
123NFIB_24661679_ChIP-Seq_LUNG_Mouse1.04626273
124STAT3_1855785_ChIP-Seq_MESCs_Mouse1.04262802
125EP300_20729851_ChIP-Seq_FORBRAIN_MIDBRAIN_LIMB_HEART_Mouse1.04212431
126* CREB1_26743006_Chip-Seq_LNCaP_Human1.03956411
127TRP63_18441228_ChIP-ChIP_KERATINOCYTES_Mouse1.03911199
128SA1_27219007_Chip-Seq_ERYTHROID_Human1.03700285
129EBNA2_21746931_ChIP-Seq_IB4-LCL_Human1.03653101
130SREBP2_21459322_ChIP-Seq_LIVER_Mouse1.02571874
131* KDM2B_26808549_Chip-Seq_JURKAT_Human1.02538102
132MYC_19030024_ChIP-ChIP_MESCs_Mouse1.02501065
133* BCOR_27268052_Chip-Seq_Bcells_Human1.02482385
134HOXB4_20404135_ChIP-ChIP_EML_Mouse1.02412378
135RACK7_27058665_Chip-Seq_MCF-7_Human1.01952173
136FLI1_20887958_ChIP-Seq_HPC-7_Mouse1.01818140
137BRD4_25478319_ChIP-Seq_HGPS_Human1.01506680
138SPI1_22096565_ChIP-ChIP_GC-B_Mouse1.00690981
139FOXO1_25302145_ChIP-Seq_T-LYMPHOCYTE_Mouse1.00004266
140MYCN_27167114_Chip-Seq_NEUROBLASTOMA_Human0.99933385
141ESR1_21235772_ChIP-Seq_MCF-7_Human0.99413901
142MYB_26560356_Chip-Seq_TH2_Human0.99401864
143BRD4_27068464_Chip-Seq_AML-cells_Mouse0.98685837
144ERG_20887958_ChIP-Seq_HPC-7_Mouse0.98464633
145NANOG_21062744_ChIP-ChIP_HESCs_Human0.98091304
146CTCF_21964334_Chip-Seq_Bcells_Human0.97839466
147NCOR_22465074_ChIP-Seq_MACROPHAGES_Mouse0.97504733
148CTCF_18555785_ChIP-Seq_MESCs_Mouse0.97196475
149TRIM28_21343339_ChIP-Seq_HEK293_Human0.97151142
150PPARG_23326641_ChIP-Seq_C3H10T1-2_Mouse0.97079028
151MYC_18358816_ChIP-ChIP_MESCs_Mouse0.96957593
152SPI1_23127762_ChIP-Seq_K562_Human0.95380596
153KLF4_19030024_ChIP-ChIP_MESCs_Mouse0.95151252
154CTCF_26484167_Chip-Seq_Bcells_Mouse0.93663343
155NELFA_20434984_ChIP-Seq_ESCs_Mouse0.93316822
156FOXO3_22982991_ChIP-Seq_MACROPHAGES_Mouse0.92617331
157NANOG_18700969_ChIP-ChIP_MESCs_Mouse0.92590219

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0010030_abnormal_orbit_morphology4.16176789
2MP0003122_maternal_imprinting3.30653588
3MP0002396_abnormal_hematopoietic_system3.14763974
4MP0002160_abnormal_reproductive_system3.14326656
5MP0000681_abnormal_thyroid_gland2.98217602
6MP0008438_abnormal_cutaneous_collagen2.92826173
7MP0003705_abnormal_hypodermis_morpholog2.80666749
8MP0005367_renal/urinary_system_phenotyp2.78597903
9MP0000516_abnormal_urinary_system2.78597903
10MP0010094_abnormal_chromosome_stability2.64971443
11MP0009697_abnormal_copulation2.60321094
12MP0004782_abnormal_surfactant_physiolog2.60130638
13MP0002009_preneoplasia2.59020103
14MP0008057_abnormal_DNA_replication2.34470640
15MP0004808_abnormal_hematopoietic_stem2.31134101
16MP0003011_delayed_dark_adaptation2.30440890
17MP0003121_genomic_imprinting2.26089948
18MP0008058_abnormal_DNA_repair2.22374147
19MP0010352_gastrointestinal_tract_polyps2.21284452
20MP0003806_abnormal_nucleotide_metabolis2.16329737
21MP0001346_abnormal_lacrimal_gland2.15444139
22MP0002938_white_spotting2.15202185
23MP0002877_abnormal_melanocyte_morpholog2.15013386
24MP0005623_abnormal_meninges_morphology2.13064402
25MP0003111_abnormal_nucleus_morphology2.09043909
26MP0005075_abnormal_melanosome_morpholog2.06117557
27MP0002249_abnormal_larynx_morphology1.99475470
28MP0002932_abnormal_joint_morphology1.97112956
29MP0001348_abnormal_lacrimal_gland1.91081847
30MP0002822_catalepsy1.87259571
31MP0008961_abnormal_basal_metabolism1.84440966
32MP0005360_urolithiasis1.78729420
33MP0003123_paternal_imprinting1.73711261
34MP0005023_abnormal_wound_healing1.72907675
35MP0001849_ear_inflammation1.69043081
36MP0002132_abnormal_respiratory_system1.68849272
37MP0009250_abnormal_appendicular_skeleto1.66423179
38MP0003786_premature_aging1.65971519
39MP0005646_abnormal_pituitary_gland1.63558689
40MP0000733_abnormal_muscle_development1.61217103
41MP0001293_anophthalmia1.61082593
42MP0005187_abnormal_penis_morphology1.60980394
43MP0003566_abnormal_cell_adhesion1.59646295
44MP0003077_abnormal_cell_cycle1.57386173
45MP0003300_gastrointestinal_ulcer1.52782056
46MP0002282_abnormal_trachea_morphology1.50735401
47MP0004036_abnormal_muscle_relaxation1.50318164
48MP0004272_abnormal_basement_membrane1.49940515
49MP0005275_abnormal_skin_tensile1.49044174
50MP0002108_abnormal_muscle_morphology1.47751938
51MP0010368_abnormal_lymphatic_system1.47742665
52MP0000428_abnormal_craniofacial_morphol1.45301121
53MP0003828_pulmonary_edema1.45002443
54MP0006054_spinal_hemorrhage1.42063877
55MP0003279_aneurysm1.41577062
56MP0001188_hyperpigmentation1.37875252
57MP0003942_abnormal_urinary_system1.37353738
58MP0003436_decreased_susceptibility_to1.36605844
59MP0003943_abnormal_hepatobiliary_system1.36504435
60MP0000537_abnormal_urethra_morphology1.34467008
61MP0003646_muscle_fatigue1.33338644
62MP0010307_abnormal_tumor_latency1.33106274
63MP0000465_gastrointestinal_hemorrhage1.32913029
64MP0006292_abnormal_olfactory_placode1.32670331
65MP0005389_reproductive_system_phenotype1.32478180
66MP0003385_abnormal_body_wall1.29426617
67MP0003763_abnormal_thymus_physiology1.28793806
68MP0009278_abnormal_bone_marrow1.28208036
69MP0004233_abnormal_muscle_weight1.27524775
70MP0001664_abnormal_digestion1.27369574
71MP0005503_abnormal_tendon_morphology1.27220398
72MP0004957_abnormal_blastocyst_morpholog1.25729099
73MP0002060_abnormal_skin_morphology1.25124495
74MP0005058_abnormal_lysosome_morphology1.24702446
75* MP0002114_abnormal_axial_skeleton1.23594713
76MP0005464_abnormal_platelet_physiology1.22517850
77MP0001545_abnormal_hematopoietic_system1.22400690
78MP0005397_hematopoietic_system_phenotyp1.22400690
79MP0000467_abnormal_esophagus_morphology1.22155756
80MP0005670_abnormal_white_adipose1.18881044
81MP0001881_abnormal_mammary_gland1.18549986
82MP0004264_abnormal_extraembryonic_tissu1.17370657
83MP0008007_abnormal_cellular_replicative1.16062535
84MP0004134_abnormal_chest_morphology1.15663028
85MP0002277_abnormal_respiratory_mucosa1.15267568
86MP0000490_abnormal_crypts_of1.13408276
87MP0005645_abnormal_hypothalamus_physiol1.13052542
88MP0009379_abnormal_foot_pigmentation1.12961504
89MP0002092_abnormal_eye_morphology1.12333277
90MP0002254_reproductive_system_inflammat1.12162268
91MP0000534_abnormal_ureter_morphology1.11803805
92MP0004084_abnormal_cardiac_muscle1.10788299
93MP0004197_abnormal_fetal_growth/weight/1.10063638
94MP0005174_abnormal_tail_pigmentation1.08687287
95MP0002925_abnormal_cardiovascular_devel1.08469023
96MP0003315_abnormal_perineum_morphology1.07678017
97MP0005508_abnormal_skeleton_morphology1.05763741
98MP0000759_abnormal_skeletal_muscle1.05230535
99MP0003787_abnormal_imprinting1.05098908
100MP0003045_fibrosis1.05091999
101MP0002113_abnormal_skeleton_development1.04661438
102MP0008932_abnormal_embryonic_tissue1.02380329
103MP0008995_early_reproductive_senescence1.01659652
104MP0002234_abnormal_pharynx_morphology1.01625405
105MP0002109_abnormal_limb_morphology1.01325446
106MP0002086_abnormal_extraembryonic_tissu1.01016603
107MP0000163_abnormal_cartilage_morphology1.00843369
108MP0002098_abnormal_vibrissa_morphology0.99002324
109MP0000538_abnormal_urinary_bladder0.97867561
110MP0010630_abnormal_cardiac_muscle0.96959090
111MP0005257_abnormal_intraocular_pressure0.96910839
112MP0003091_abnormal_cell_migration0.96653067
113MP0000762_abnormal_tongue_morphology0.95974214
114MP0005076_abnormal_cell_differentiation0.95860830
115MP0003693_abnormal_embryo_hatching0.94544129
116MP0003252_abnormal_bile_duct0.94262080
117MP0003935_abnormal_craniofacial_develop0.93350921
118MP0002398_abnormal_bone_marrow0.93330885
119MP0002115_abnormal_skeleton_extremities0.91625397
120MP0000767_abnormal_smooth_muscle0.90439805
121MP0001502_abnormal_circadian_rhythm0.88237736
122MP0002095_abnormal_skin_pigmentation0.87943587
123MP0000678_abnormal_parathyroid_gland0.87597161
124MP0001614_abnormal_blood_vessel0.87060900
125MP0000350_abnormal_cell_proliferation0.86679496
126MP0000858_altered_metastatic_potential0.86565671
127MP0005197_abnormal_uvea_morphology0.86444977
128MP0001672_abnormal_embryogenesis/_devel0.83984743
129MP0005380_embryogenesis_phenotype0.83984743
130MP0000703_abnormal_thymus_morphology0.82614099
131MP0001501_abnormal_sleep_pattern0.82605241
132MP0005330_cardiomyopathy0.82591353
133MP0002177_abnormal_outer_ear0.82195545
134MP0000470_abnormal_stomach_morphology0.81929610
135MP0002722_abnormal_immune_system0.80408487
136MP0001958_emphysema0.80401964
137MP0001243_abnormal_dermal_layer0.80242049
138MP0002166_altered_tumor_susceptibility0.80048755
139MP0002088_abnormal_embryonic_growth/wei0.79944850
140MP0002019_abnormal_tumor_incidence0.78967618
141MP0001764_abnormal_homeostasis0.78711014
142MP0002128_abnormal_blood_circulation0.78670845
143MP0003984_embryonic_growth_retardation0.78602808
144MP0006036_abnormal_mitochondrial_physio0.77883009
145MP0008770_decreased_survivor_rate0.77646975
146MP0000372_irregular_coat_pigmentation0.77441596
147MP0009931_abnormal_skin_appearance0.77284875
148MP0003567_abnormal_fetal_cardiomyocyte0.76851566
149MP0002837_dystrophic_cardiac_calcinosis0.76518611
150MP0001175_abnormal_lung_morphology0.76021073
151MP0000383_abnormal_hair_follicle0.75856740
152MP0001270_distended_abdomen0.75659668
153MP0009053_abnormal_anal_canal0.75240276
154MP0000749_muscle_degeneration0.74799825
155MP0000003_abnormal_adipose_tissue0.74488253
156MP0005621_abnormal_cell_physiology0.74464328
157MP0002928_abnormal_bile_duct0.74123807
158MP0000598_abnormal_liver_morphology0.74066729
159MP0005390_skeleton_phenotype0.74031163
160MP0001851_eye_inflammation0.73906912
161MP0002269_muscular_atrophy0.69114308
162MP0000313_abnormal_cell_death0.68117841
163MP0010678_abnormal_skin_adnexa0.67267240
164MP0004484_altered_response_of0.67036540
165MP0002127_abnormal_cardiovascular_syste0.67013534
166MP0000689_abnormal_spleen_morphology0.66955578
167MP0000627_abnormal_mammary_gland0.63548258

Predicted human phenotypes

RankGene SetZ-score
1Abnormality of the columella (HP:0009929)4.48355407
2Septate vagina (HP:0001153)4.43015767
3Cerebellar dysplasia (HP:0007033)4.25964009
4Renal duplication (HP:0000075)4.09624319
5Buphthalmos (HP:0000557)3.77070283
6Increased density of long bones (HP:0006392)3.75346045
7Hyperacusis (HP:0010780)3.72659286
8Clumsiness (HP:0002312)3.53074280
9Poor eye contact (HP:0000817)3.42343977
10Hepatoblastoma (HP:0002884)3.40121959
11Protrusio acetabuli (HP:0003179)3.31556601
12Type II lissencephaly (HP:0007260)3.20193734
13Aplastic anemia (HP:0001915)3.17966227
14Spinal rigidity (HP:0003306)3.17675181
15Abnormal umbilical cord blood vessels (HP:0011403)3.17520819
16Single umbilical artery (HP:0001195)3.17520819
17Abnormality of the fetal cardiovascular system (HP:0010948)3.17520819
18Increased neuronal autofluorescent lipopigment (HP:0002074)3.11610958
19Intracellular accumulation of autofluorescent lipopigment storage material (HP:0003204)3.07327969
20Prostate neoplasm (HP:0100787)3.05311395
21Ankle contracture (HP:0006466)2.95567442
22Aplasia/Hypoplasia of the 4th metacarpal (HP:0010042)2.94585847
23Short 4th metacarpal (HP:0010044)2.94585847
24Exercise-induced myalgia (HP:0003738)2.86472582
25Tinnitus (HP:0000360)2.82656173
26Anterior segment dysgenesis (HP:0007700)2.81696405
27Premature rupture of membranes (HP:0001788)2.76929829
28Increased cerebral lipofuscin (HP:0011813)2.75702520
29Microretrognathia (HP:0000308)2.75676834
30Bladder diverticulum (HP:0000015)2.74725287
31Birth length less than 3rd percentile (HP:0003561)2.65140690
32Abnormality of the peritoneum (HP:0002585)2.64885371
33Absent frontal sinuses (HP:0002688)2.63859788
34Truncus arteriosus (HP:0001660)2.62265051
35Ulnar bowing (HP:0003031)2.62196505
36Dysmetric saccades (HP:0000641)2.61799670
37Calcaneovalgus deformity (HP:0001848)2.61371378
38Lip pit (HP:0100267)2.61168673
39Progressive muscle weakness (HP:0003323)2.59575087
40Vacuolated lymphocytes (HP:0001922)2.57287603
41Ependymoma (HP:0002888)2.57083697
42Abnormal number of incisors (HP:0011064)2.53761051
43Centrally nucleated skeletal muscle fibers (HP:0003687)2.53710752
44Macroorchidism (HP:0000053)2.52153053
45Abnormality of the parietal bone (HP:0002696)2.50478500
46Peritonitis (HP:0002586)2.50165150
47Overriding aorta (HP:0002623)2.49983216
48Abnormality of the 4th metacarpal (HP:0010012)2.49833712
49Renovascular hypertension (HP:0100817)2.49815613
50Abnormal protein glycosylation (HP:0012346)2.49157839
51Abnormal glycosylation (HP:0012345)2.49157839
52Abnormal isoelectric focusing of serum transferrin (HP:0003160)2.49157839
53Abnormal protein N-linked glycosylation (HP:0012347)2.49157839
54Petechiae (HP:0000967)2.48922148
55Syringomyelia (HP:0003396)2.46260129
56Spinal cord lesions (HP:0100561)2.46260129
57Soft skin (HP:0000977)2.45592961
58Elfin facies (HP:0004428)2.44869868
59Radial bowing (HP:0002986)2.44699626
60Thoracic kyphosis (HP:0002942)2.42723357
61Abnormality of homocysteine metabolism (HP:0010919)2.41711537
62Homocystinuria (HP:0002156)2.41711537
63Bowel diverticulosis (HP:0005222)2.41629998
64Abnormality of T cell physiology (HP:0011840)2.36666329
65Increased connective tissue (HP:0009025)2.35320470
66Severe combined immunodeficiency (HP:0004430)2.33002211
67Short phalanx of the thumb (HP:0009660)2.31689532
68Protruding tongue (HP:0010808)2.30551946
69Distal arthrogryposis (HP:0005684)2.29885428
70Abnormality of DNA repair (HP:0003254)2.28924180
71Chromsome breakage (HP:0040012)2.27970654
72Increased variability in muscle fiber diameter (HP:0003557)2.27427334
73Deformed tarsal bones (HP:0008119)2.25648630
74Submucous cleft hard palate (HP:0000176)2.25379693
75Increased muscle lipid content (HP:0009058)2.25128225
76Self-mutilation (HP:0000742)2.24214723
77Reduced antithrombin III activity (HP:0001976)2.23810035
78Persistence of primary teeth (HP:0006335)2.22040147
79Flat cornea (HP:0007720)2.21445744
80Acute lymphatic leukemia (HP:0006721)2.21156563
81Bundle branch block (HP:0011710)2.20921490
82Mesomelia (HP:0003027)2.20552487
83Abnormality of skeletal muscle fiber size (HP:0012084)2.19618341
84Ragged-red muscle fibers (HP:0003200)2.19519127
85Deviation of the hallux (HP:0010051)2.18951363
86Chromosomal breakage induced by crosslinking agents (HP:0003221)2.18870669
87Congenital glaucoma (HP:0001087)2.18703464
88Hallux valgus (HP:0001822)2.17482167
89Selective tooth agenesis (HP:0001592)2.17014035
90Optic nerve coloboma (HP:0000588)2.16392528
91Spontaneous abortion (HP:0005268)2.15987382
92Short thumb (HP:0009778)2.15975714
93Abnormality of the umbilical cord (HP:0010881)2.15389875
94Broad distal phalanx of finger (HP:0009836)2.14695848
95Abnormality of alanine metabolism (HP:0010916)2.13454093
96Hyperalaninemia (HP:0003348)2.13454093
97Abnormality of pyruvate family amino acid metabolism (HP:0010915)2.13454093
98Premature ovarian failure (HP:0008209)2.13400180
99Myopathic facies (HP:0002058)2.12413196
100Broad thumb (HP:0011304)2.12236366
101Abnormality of the sella turcica (HP:0002679)2.11627546
102Absent phalangeal crease (HP:0006109)2.09175101
103Retinal dysplasia (HP:0007973)2.08210002
104Rhabdomyosarcoma (HP:0002859)2.07638347
105Thrombocytosis (HP:0001894)2.07336646
106Hypoplasia of the iris (HP:0007676)2.05998590
107Abnormality of the fingertips (HP:0001211)2.05190649
108Opisthotonus (HP:0002179)2.05158552
109Mitral valve prolapse (HP:0001634)2.04664953
110Aplasia/Hypoplasia of the frontal sinuses (HP:0009119)2.04600075
111Muscle hypertrophy of the lower extremities (HP:0008968)2.04440341
112Cervical subluxation (HP:0003308)2.04178440
113Bowed forearm bones (HP:0003956)2.03858308
114Bowing of the arm (HP:0006488)2.03858308
115Impaired social interactions (HP:0000735)2.00659610
116Abnormal social behavior (HP:0012433)2.00659610
117Partial duplication of the phalanx of hand (HP:0009999)1.99593742
118Neoplasm of striated muscle (HP:0009728)1.99029481
119Long eyelashes (HP:0000527)1.99022167
120Wormian bones (HP:0002645)1.96822662
121Decreased skull ossification (HP:0004331)1.96802010
122Osteolytic defects of the hand bones (HP:0009699)1.95754189
123Osteolytic defects of the phalanges of the hand (HP:0009771)1.95754189
124Short 1st metacarpal (HP:0010034)1.94168936
125Aplasia/Hypoplasia of the 1st metacarpal (HP:0010026)1.94168936
126Abnormality of the astrocytes (HP:0100707)1.93812779
127Astrocytoma (HP:0009592)1.93812779
128Aplasia/Hypoplasia of the patella (HP:0006498)1.93048696
129Abnormality of the thoracic spine (HP:0100711)1.93034149
130Neoplasm of the adrenal cortex (HP:0100641)1.91195518
131Abnormality of the prostate (HP:0008775)1.90745523
132Calf muscle hypertrophy (HP:0008981)1.90225851
133Patellar aplasia (HP:0006443)1.90077337
134Capillary hemangiomas (HP:0005306)1.90032693
135Broad face (HP:0000283)1.88879444
136Autoimmune hemolytic anemia (HP:0001890)1.88501364
137Broad palm (HP:0001169)1.88355978
138Transposition of the great arteries (HP:0001669)1.88050122
139Abnormal connection of the cardiac segments (HP:0011545)1.88050122
140Abnormal ventriculo-arterial connection (HP:0011563)1.88050122
141Pancytopenia (HP:0001876)1.86309975
142Granulocytopenia (HP:0001913)1.85132729
143Increased intramyocellular lipid droplets (HP:0012240)1.85099214
144Acute myeloid leukemia (HP:0004808)1.84653789
145Hypergonadotropic hypogonadism (HP:0000815)1.83141364
146Shallow orbits (HP:0000586)1.82905340
147Aortic aneurysm (HP:0004942)1.82875362
148Supernumerary bones of the axial skeleton (HP:0009144)1.82486260
149Autoimmune thrombocytopenia (HP:0001973)1.81785871
150Thin bony cortex (HP:0002753)1.81527565
151Medulloblastoma (HP:0002885)1.80223896
152Type I transferrin isoform profile (HP:0003642)1.79926197
153Embryonal renal neoplasm (HP:0011794)1.76961089
154Prominent nose (HP:0000448)1.76874779
155Partial duplication of thumb phalanx (HP:0009944)1.76389913
156Supernumerary nipples (HP:0002558)1.76230345
157Abnormality of skull ossification (HP:0002703)1.76160314
158Increased nuchal translucency (HP:0010880)1.74991614
159Cellulitis (HP:0100658)1.74285518
160Bilateral microphthalmos (HP:0007633)1.74097914
161Abnormality of cells of the erythroid lineage (HP:0012130)1.73414659
162Neonatal hypoglycemia (HP:0001998)1.73143726
163Abnormality of the 1st metacarpal (HP:0010009)1.73112004
164Abnormality of B cell number (HP:0010975)1.71628338
165Insomnia (HP:0100785)1.71594930
166Lymphangioma (HP:0100764)1.71396476
167Ulnar deviation of the wrist (HP:0003049)1.71235908
168Myelodysplasia (HP:0002863)1.69935849
169Skin tags (HP:0010609)1.69849481
170Elbow flexion contracture (HP:0002987)1.69272924
171Abnormality of cochlea (HP:0000375)1.68560100
172Reticulocytopenia (HP:0001896)1.68487984
173Aplasia/Hypoplasia of the phalanges of the thumb (HP:0009658)1.67437716
174Sensory axonal neuropathy (HP:0003390)1.67403873
175Abnormal number of erythroid precursors (HP:0012131)1.66881033
176Osteomyelitis (HP:0002754)1.66772725
177Nephroblastoma (Wilms tumor) (HP:0002667)1.66215314
178Subacute progressive viral hepatitis (HP:0006572)1.65565404
179Prolonged bleeding time (HP:0003010)1.64680064
180Intellectual disability, profound (HP:0002187)1.64665827
181Aortic dissection (HP:0002647)1.63731071
182Missing ribs (HP:0000921)1.63290533
183Progressive inability to walk (HP:0002505)1.63054579
184Generalized amyotrophy (HP:0003700)1.62305440
185Asymmetry of the thorax (HP:0001555)1.62235479
186Abnormality of the distal phalanx of the thumb (HP:0009617)1.61095206
187Increased serum ferritin (HP:0003281)1.60342453
188Atrophic scars (HP:0001075)1.59248085

Predicted kinase interactions (KEA)

RankGene SetZ-score
1PIK3CG4.93718040
2EEF2K3.57308661
3FLT33.56802203
4BCKDK3.53890932
5MAP3K103.46759337
6TRIB33.44910700
7CDK123.20766935
8KIT2.77558371
9ERN12.65216741
10ZAK2.64018164
11CSF1R2.50958585
12PAK42.44573713
13PKN22.43216881
14PINK12.36243674
15LRRK22.34588440
16FES2.22722158
17MAP2K22.11246878
18TLK12.01411121
19MATK2.00850854
20RPS6KB21.94754085
21TTN1.91291214
22TNK21.84674205
23MAPK151.76260127
24MAP3K141.75093579
25KDR1.72840783
26VRK11.71590367
27ALK1.68135530
28OBSCN1.67302639
29MAP4K21.61349833
30PIK3CA1.57805761
31IRAK31.57456995
32PRKD31.56480837
33NUAK11.56170878
34GRK61.51936070
35MAP2K31.48819952
36SIK11.45750663
37EPHB11.44011703
38PDGFRA1.42882267
39BMPR1B1.41671167
40CAMK1G1.39464559
41CHEK21.37727775
42IRAK21.32928482
43MAPK111.32233721
44TAOK31.31776135
45FRK1.29866262
46PAK21.25864068
47CDC71.23885000
48TEC1.20924235
49MKNK21.19873718
50DDR21.17055323
51PIM21.12415081
52WNK11.11012963
53CCNB11.08624842
54BMX1.08485007
55MAP3K121.08457691
56BTK1.03025359
57PRKG21.02763228
58STK101.01033491
59AURKA1.00811763
60MARK31.00402943
61RET0.99757636
62SMG10.99343560
63PTK20.98026441
64MAP3K10.96210250
65PDGFRB0.94893630
66TGFBR20.93431893
67PTK60.92072207
68ILK0.90338850
69TGFBR10.90324790
70MARK20.89904030
71ABL20.89436341
72LATS10.88006895
73MAP2K60.87771363
74SIK20.87546790
75RIPK10.87092523
76SIK30.85770226
77CDK80.85186501
78LATS20.83451574
79CDK70.80159838
80MTOR0.80154367
81CDK60.79896958
82CDK20.79533320
83ICK0.79197455
84BRD40.79100157
85HIPK20.78866336
86NME20.78484593
87PIM10.78123593
88PRKCQ0.77134806
89MAP4K10.76944830
90ZAP700.74404167
91ATM0.74104019
92TRPM70.73560179
93EIF2AK20.73500054
94MST1R0.73158285
95MKNK10.72910428
96TSSK60.72057218
97MAP3K30.70355202
98PASK0.69312796
99PRKCH0.69288844
100AURKB0.68482982
101CLK10.67200017
102TTK0.66030359
103RPS6KA50.65906195
104CDK40.65364540
105NTRK10.64983182
106VRK20.59826279
107MET0.58630808
108CSNK1A1L0.56375196
109MAP3K70.55756621
110EPHA30.54745640
111MAPK70.53207976
112CDK30.52784094
113PRKD10.52174414
114WEE10.51930298
115TBK10.51229976
116AKT20.50918326
117BUB10.49398344
118MAP3K110.49019021
119RPS6KB10.48860203
120PRKAA10.48577756
121CDK10.48381138
122MYLK0.46873215
123MAPKAPK30.46638807
124PRKD20.46512555
125STK40.46152408
126TESK20.46058615
127TIE10.45571172
128CAMK40.44848989
129MAPK140.44651411
130MAPK130.44289016
131IGF1R0.43146270
132MELK0.43140847
133MAP3K60.43010966
134GSK3B0.42270280
135SCYL20.42268886
136TAOK20.42082223
137RPS6KA10.42077683
138AKT10.42011717
139MAPK30.41560134
140ATR0.38975199
141LCK0.36862591
142CAMK1D0.36764722
143PTK2B0.36344595
144MAP2K10.36024450
145PLK10.35737595
146ADRBK10.35140946
147MAPK10.34313447
148PBK0.33585309
149RPS6KL10.33518635
150RPS6KC10.33518635
151RPS6KA60.33274693
152CDK90.32415073
153IRAK40.31104282
154CHUK0.30197843
155DYRK30.30195233
156NEK20.28435186
157MAPK90.27717672
158CHEK10.27155872
159MAPK40.27071432
160HCK0.26474532
161MAP3K80.26092074
162IKBKB0.25872659

Predicted pathways (KEGG)

RankGene SetZ-score
1Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007603.00478315
2Ribosome_Homo sapiens_hsa030102.90508740
3Homologous recombination_Homo sapiens_hsa034402.77135394
4Sulfur relay system_Homo sapiens_hsa041222.42321668
5Non-homologous end-joining_Homo sapiens_hsa034502.38166993
6Pyrimidine metabolism_Homo sapiens_hsa002402.27856760
7Acute myeloid leukemia_Homo sapiens_hsa052212.27828164
8Lysine degradation_Homo sapiens_hsa003102.19625627
9Small cell lung cancer_Homo sapiens_hsa052222.19369089
10Nucleotide excision repair_Homo sapiens_hsa034202.17547926
11Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate_Homo sapiens_hsa005322.07576049
12Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005631.94383220
13Transcriptional misregulation in cancer_Homo sapiens_hsa052021.92243141
14Other types of O-glycan biosynthesis_Homo sapiens_hsa005141.87839062
15ECM-receptor interaction_Homo sapiens_hsa045121.87453089
16Non-small cell lung cancer_Homo sapiens_hsa052231.84364938
17Central carbon metabolism in cancer_Homo sapiens_hsa052301.83129572
18Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006011.82444315
19B cell receptor signaling pathway_Homo sapiens_hsa046621.80299941
20Other glycan degradation_Homo sapiens_hsa005111.80256550
21Chronic myeloid leukemia_Homo sapiens_hsa052201.78024258
22Proteoglycans in cancer_Homo sapiens_hsa052051.77184375
23Focal adhesion_Homo sapiens_hsa045101.75869734
24RNA polymerase_Homo sapiens_hsa030201.74970965
25Fanconi anemia pathway_Homo sapiens_hsa034601.74302790
26Fc epsilon RI signaling pathway_Homo sapiens_hsa046641.69901307
27mTOR signaling pathway_Homo sapiens_hsa041501.67543195
28Selenocompound metabolism_Homo sapiens_hsa004501.66923479
29Platelet activation_Homo sapiens_hsa046111.65400367
30Leukocyte transendothelial migration_Homo sapiens_hsa046701.64282840
31AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa049331.55099054
32Regulation of autophagy_Homo sapiens_hsa041401.54695218
33Bacterial invasion of epithelial cells_Homo sapiens_hsa051001.51971658
34VEGF signaling pathway_Homo sapiens_hsa043701.48395000
35Endometrial cancer_Homo sapiens_hsa052131.46811097
36Neurotrophin signaling pathway_Homo sapiens_hsa047221.44599824
37Pentose phosphate pathway_Homo sapiens_hsa000301.41482964
38Circadian rhythm_Homo sapiens_hsa047101.38673031
39Purine metabolism_Homo sapiens_hsa002301.36086304
40MicroRNAs in cancer_Homo sapiens_hsa052061.36026020
41Systemic lupus erythematosus_Homo sapiens_hsa053221.33330764
42Thyroid cancer_Homo sapiens_hsa052161.28601444
43Amoebiasis_Homo sapiens_hsa051461.27120409
44Glioma_Homo sapiens_hsa052141.25725228
45Toxoplasmosis_Homo sapiens_hsa051451.23593832
46Insulin resistance_Homo sapiens_hsa049311.19192937
47Viral carcinogenesis_Homo sapiens_hsa052031.19185494
48Basal cell carcinoma_Homo sapiens_hsa052171.17106295
49HTLV-I infection_Homo sapiens_hsa051661.14928902
50Carbohydrate digestion and absorption_Homo sapiens_hsa049731.14782590
51PI3K-Akt signaling pathway_Homo sapiens_hsa041511.14071153
52Leishmaniasis_Homo sapiens_hsa051401.12900089
53Fc gamma R-mediated phagocytosis_Homo sapiens_hsa046661.10225948
54Pancreatic cancer_Homo sapiens_hsa052121.08280785
55Regulation of lipolysis in adipocytes_Homo sapiens_hsa049231.07271941
56Pathways in cancer_Homo sapiens_hsa052001.05926706
57Olfactory transduction_Homo sapiens_hsa047401.05105917
58Osteoclast differentiation_Homo sapiens_hsa043801.04679010
59Drug metabolism - other enzymes_Homo sapiens_hsa009831.03710313
60Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa009701.03522226
61Prostate cancer_Homo sapiens_hsa052151.03133751
62RNA transport_Homo sapiens_hsa030131.02960369
63Hepatitis C_Homo sapiens_hsa051601.01968983
64Protein processing in endoplasmic reticulum_Homo sapiens_hsa041411.01812529
65Prolactin signaling pathway_Homo sapiens_hsa049171.01283589
66Colorectal cancer_Homo sapiens_hsa052101.01242398
67Spliceosome_Homo sapiens_hsa030400.94718273
68Shigellosis_Homo sapiens_hsa051310.94635308
69Herpes simplex infection_Homo sapiens_hsa051680.92953422
70Cell cycle_Homo sapiens_hsa041100.92509911
71Tryptophan metabolism_Homo sapiens_hsa003800.92086487
72Bladder cancer_Homo sapiens_hsa052190.91831054
73TNF signaling pathway_Homo sapiens_hsa046680.91054046
74Epstein-Barr virus infection_Homo sapiens_hsa051690.90991594
75Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa045500.90498409
76Hepatitis B_Homo sapiens_hsa051610.89851729
77Regulation of actin cytoskeleton_Homo sapiens_hsa048100.89741174
78Cyanoamino acid metabolism_Homo sapiens_hsa004600.89702462
79Protein digestion and absorption_Homo sapiens_hsa049740.89506824
80Cytosolic DNA-sensing pathway_Homo sapiens_hsa046230.89419347
81HIF-1 signaling pathway_Homo sapiens_hsa040660.89255740
82DNA replication_Homo sapiens_hsa030300.88914693
83Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006030.88845682
84Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030080.88301384
85RNA degradation_Homo sapiens_hsa030180.87981907
86One carbon pool by folate_Homo sapiens_hsa006700.86611903
87Melanoma_Homo sapiens_hsa052180.86198116
88Steroid hormone biosynthesis_Homo sapiens_hsa001400.86139619
89Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005330.85909381
90Jak-STAT signaling pathway_Homo sapiens_hsa046300.81285569
91Cysteine and methionine metabolism_Homo sapiens_hsa002700.81112615
92Folate biosynthesis_Homo sapiens_hsa007900.81107531
93Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006300.80347607
94Thyroid hormone signaling pathway_Homo sapiens_hsa049190.79769809
95Longevity regulating pathway - multiple species_Homo sapiens_hsa042130.78675755
96N-Glycan biosynthesis_Homo sapiens_hsa005100.77290827
97p53 signaling pathway_Homo sapiens_hsa041150.77280782
98AMPK signaling pathway_Homo sapiens_hsa041520.77169458
99Galactose metabolism_Homo sapiens_hsa000520.77095801
100Rap1 signaling pathway_Homo sapiens_hsa040150.76370379
101RIG-I-like receptor signaling pathway_Homo sapiens_hsa046220.76086550
102Apoptosis_Homo sapiens_hsa042100.75962182
103Hematopoietic cell lineage_Homo sapiens_hsa046400.75943049
104Longevity regulating pathway - mammal_Homo sapiens_hsa042110.74961417
105Estrogen signaling pathway_Homo sapiens_hsa049150.74716610
106Ubiquitin mediated proteolysis_Homo sapiens_hsa041200.74261317
107Mismatch repair_Homo sapiens_hsa034300.74125257
108Salivary secretion_Homo sapiens_hsa049700.73085075
109Pathogenic Escherichia coli infection_Homo sapiens_hsa051300.72683567
110Pantothenate and CoA biosynthesis_Homo sapiens_hsa007700.71604658
111Measles_Homo sapiens_hsa051620.69716040
112Notch signaling pathway_Homo sapiens_hsa043300.69273100
113Chagas disease (American trypanosomiasis)_Homo sapiens_hsa051420.68844280
114Amyotrophic lateral sclerosis (ALS)_Homo sapiens_hsa050140.68786278
115Adherens junction_Homo sapiens_hsa045200.68713874
116cGMP-PKG signaling pathway_Homo sapiens_hsa040220.68474820
117Progesterone-mediated oocyte maturation_Homo sapiens_hsa049140.68306191
118Peroxisome_Homo sapiens_hsa041460.66611812
119Renin-angiotensin system_Homo sapiens_hsa046140.66163739
120Alcoholism_Homo sapiens_hsa050340.65394655
121Calcium signaling pathway_Homo sapiens_hsa040200.63247748
122Antigen processing and presentation_Homo sapiens_hsa046120.62712724
123Choline metabolism in cancer_Homo sapiens_hsa052310.61647614
124Influenza A_Homo sapiens_hsa051640.61570062
125Phospholipase D signaling pathway_Homo sapiens_hsa040720.61542973
126T cell receptor signaling pathway_Homo sapiens_hsa046600.60763093
127mRNA surveillance pathway_Homo sapiens_hsa030150.60463964
128FoxO signaling pathway_Homo sapiens_hsa040680.58920787
129Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008600.58366594
130Insulin signaling pathway_Homo sapiens_hsa049100.58136330
131Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa005340.55457492
132Valine, leucine and isoleucine degradation_Homo sapiens_hsa002800.54931108
133Nitrogen metabolism_Homo sapiens_hsa009100.53532295
134Renal cell carcinoma_Homo sapiens_hsa052110.53207258
135Base excision repair_Homo sapiens_hsa034100.53033320
136Glycosaminoglycan degradation_Homo sapiens_hsa005310.51736350
137Phototransduction_Homo sapiens_hsa047440.51358831
138Oocyte meiosis_Homo sapiens_hsa041140.51173760
139Toll-like receptor signaling pathway_Homo sapiens_hsa046200.50178537
140Oxytocin signaling pathway_Homo sapiens_hsa049210.49572516
141Basal transcription factors_Homo sapiens_hsa030220.49292855
142NF-kappa B signaling pathway_Homo sapiens_hsa040640.46859763
143Primary immunodeficiency_Homo sapiens_hsa053400.45582474
144Dorso-ventral axis formation_Homo sapiens_hsa043200.45478704
145Adipocytokine signaling pathway_Homo sapiens_hsa049200.45299819
146Pentose and glucuronate interconversions_Homo sapiens_hsa000400.45286114
147Glucagon signaling pathway_Homo sapiens_hsa049220.43746585
148Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004000.39707684
149SNARE interactions in vesicular transport_Homo sapiens_hsa041300.39676109
150Phosphatidylinositol signaling system_Homo sapiens_hsa040700.38630847
151Neuroactive ligand-receptor interaction_Homo sapiens_hsa040800.36971687
152Butanoate metabolism_Homo sapiens_hsa006500.31414971
153Biosynthesis of amino acids_Homo sapiens_hsa012300.30827177
154Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009800.29859947
155Metabolic pathways_Homo sapiens_hsa011000.29058703
156Fructose and mannose metabolism_Homo sapiens_hsa000510.28295520
157Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001300.27504491
158Taste transduction_Homo sapiens_hsa047420.27126087
159Drug metabolism - cytochrome P450_Homo sapiens_hsa009820.26138580
160Aldosterone synthesis and secretion_Homo sapiens_hsa049250.25782102
161Gastric acid secretion_Homo sapiens_hsa049710.25754856
162NOD-like receptor signaling pathway_Homo sapiens_hsa046210.25677935
1632-Oxocarboxylic acid metabolism_Homo sapiens_hsa012100.25240248
164Arachidonic acid metabolism_Homo sapiens_hsa005900.23154009

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