HOXA7

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: In vertebrates, the genes encoding the class of transcription factors called homeobox genes are found in clusters named A, B, C, and D on four separate chromosomes. Expression of these proteins is spatially and temporally regulated during embryonic development. This gene is part of the A cluster on chromosome 7 and encodes a DNA-binding transcription factor which may regulate gene expression, morphogenesis, and differentiation. For example, the encoded protein represses the transcription of differentiation-specific genes during keratinocyte proliferation, but this repression is then overcome by differentiation signals. This gene is highly similar to the antennapedia (Antp) gene of Drosophila. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1ribosomal small subunit assembly (GO:0000028)7.07020354
2viral transcription (GO:0019083)6.77955116
3ribosomal small subunit biogenesis (GO:0042274)6.61491560
4translational termination (GO:0006415)6.40976104
5daunorubicin metabolic process (GO:0044597)6.14825907
6polyketide metabolic process (GO:0030638)6.14825907
7doxorubicin metabolic process (GO:0044598)6.14825907
8piRNA metabolic process (GO:0034587)5.97384231
9aminoglycoside antibiotic metabolic process (GO:0030647)5.86715169
10translational elongation (GO:0006414)5.50562242
11SRP-dependent cotranslational protein targeting to membrane (GO:0006614)5.48076947
12thyroid gland development (GO:0030878)5.37858996
13cotranslational protein targeting to membrane (GO:0006613)5.35007217
14protein targeting to ER (GO:0045047)5.33293121
15phospholipase C-activating dopamine receptor signaling pathway (GO:0060158)5.32271138
16purine nucleotide salvage (GO:0032261)5.28298268
17viral life cycle (GO:0019058)5.10909407
18maturation of SSU-rRNA (GO:0030490)5.10847016
19nuclear-transcribed mRNA catabolic process, nonsense-mediated decay (GO:0000184)5.09133804
20establishment of protein localization to endoplasmic reticulum (GO:0072599)5.07490217
21ADP metabolic process (GO:0046031)5.04105030
22protein localization to endoplasmic reticulum (GO:0070972)5.00281828
23cellular protein complex disassembly (GO:0043624)4.87161121
24AMP metabolic process (GO:0046033)4.80988388
25regulation of apoptotic process involved in morphogenesis (GO:1902337)4.80601654
26regulation of female gonad development (GO:2000194)4.76036301
27mature B cell differentiation involved in immune response (GO:0002313)4.60233079
28translational initiation (GO:0006413)4.47229652
29deoxyribonucleoside monophosphate metabolic process (GO:0009162)4.46985710
30regulation of mammary gland epithelial cell proliferation (GO:0033599)4.46934827
31negative regulation of B cell apoptotic process (GO:0002903)4.42126107
32protein complex disassembly (GO:0043241)4.34289543
33definitive hemopoiesis (GO:0060216)4.31084084
34positive regulation of catecholamine secretion (GO:0033605)4.16420752
35DNA methylation involved in gamete generation (GO:0043046)4.13530696
36ribosomal large subunit biogenesis (GO:0042273)4.05032460
37macromolecular complex disassembly (GO:0032984)4.04183773
38mucosal-associated lymphoid tissue development (GO:0048537)4.01551538
39Peyers patch development (GO:0048541)4.01551538
40DNA deamination (GO:0045006)3.99901477
41regulation of skeletal muscle contraction (GO:0014819)3.96392772
42negative regulation of vascular endothelial growth factor receptor signaling pathway (GO:0030948)3.84231761
43endothelium development (GO:0003158)3.82855966
44nucleotide salvage (GO:0043173)3.77371979
45ribonucleoprotein complex biogenesis (GO:0022613)3.72529286
46cranial nerve morphogenesis (GO:0021602)3.71920763
47aggressive behavior (GO:0002118)3.71577215
48* negative regulation of epidermis development (GO:0045683)3.71548776
49purine-containing compound salvage (GO:0043101)3.69768138
50nuclear-transcribed mRNA catabolic process (GO:0000956)3.69621729
51positive regulation of granulocyte macrophage colony-stimulating factor production (GO:0032725)3.68247911
52rRNA transcription (GO:0009303)3.64406006
53regulation of response to osmotic stress (GO:0047484)3.63641073
54protein targeting to membrane (GO:0006612)3.60474031
55pyrimidine deoxyribonucleotide catabolic process (GO:0009223)3.59690921
56protein localization to kinetochore (GO:0034501)3.57162258
57purine deoxyribonucleoside triphosphate metabolic process (GO:0009215)3.56243912
58mRNA catabolic process (GO:0006402)3.55204129
59multicellular organism reproduction (GO:0032504)3.50630489
60purine deoxyribonucleotide metabolic process (GO:0009151)3.49573371
61lymphoid progenitor cell differentiation (GO:0002320)3.43759824
62DNA replication checkpoint (GO:0000076)3.42401355
63muscle organ morphogenesis (GO:0048644)3.40755332
64nucleoside diphosphate biosynthetic process (GO:0009133)3.40699788
65platelet dense granule organization (GO:0060155)3.34085766
66deoxyribonucleoside triphosphate metabolic process (GO:0009200)3.32758363
67regulation of memory T cell differentiation (GO:0043380)3.30827045
68RNA catabolic process (GO:0006401)3.30646876
69negative regulation of cell cycle G2/M phase transition (GO:1902750)3.27228694
70regulation of single stranded viral RNA replication via double stranded DNA intermediate (GO:00450913.25265162
71regulation of granulocyte macrophage colony-stimulating factor production (GO:0032645)3.22846474
72muscle filament sliding (GO:0030049)3.22145101
73actin-myosin filament sliding (GO:0033275)3.22145101
74pseudouridine synthesis (GO:0001522)3.20409634
75regulation of steroid hormone secretion (GO:2000831)3.18793879
76positive regulation of odontogenesis (GO:0042482)3.17895229
77UV protection (GO:0009650)3.17668065
78negative regulation of interleukin-2 production (GO:0032703)3.16759058
792-deoxyribonucleotide metabolic process (GO:0009394)3.15110403
80mature B cell differentiation (GO:0002335)3.15019951
81positive regulation of steroid hormone secretion (GO:2000833)3.13991670
82megakaryocyte development (GO:0035855)3.13743586
83regulation of nuclear cell cycle DNA replication (GO:0033262)3.13453205
84mesonephros development (GO:0001823)3.13297693
85translation (GO:0006412)3.13131237
86DNA unwinding involved in DNA replication (GO:0006268)3.12236422
87regulation of female receptivity (GO:0045924)3.11397567
88male meiosis I (GO:0007141)3.10771174
89synapsis (GO:0007129)3.07694217
90negative regulation of phagocytosis (GO:0050765)3.06505505
91negative regulation of circadian rhythm (GO:0042754)3.06371059
92reproduction (GO:0000003)3.04994846
93purine deoxyribonucleotide catabolic process (GO:0009155)3.04487246
94deoxyribonucleotide catabolic process (GO:0009264)3.02427169
95negative regulation of erythrocyte differentiation (GO:0045647)3.01127699
96female mating behavior (GO:0060180)3.00703737
97positive regulation of T-helper cell differentiation (GO:0045624)2.99535995
98grooming behavior (GO:0007625)2.98253393
99cellular ketone body metabolic process (GO:0046950)2.97802827
100deoxyribose phosphate catabolic process (GO:0046386)2.96800534
101deoxyribose phosphate metabolic process (GO:0019692)2.95467718
102negative regulation of fibroblast growth factor receptor signaling pathway (GO:0040037)2.94905176
103lymph vessel development (GO:0001945)2.93655189
104negative regulation of kidney development (GO:0090185)2.90737603
105muscle cell fate commitment (GO:0042693)2.86900734
106protein localization to chromosome, centromeric region (GO:0071459)2.86730050
107fertilization (GO:0009566)2.85945509
108base-excision repair, AP site formation (GO:0006285)2.85334233
109single fertilization (GO:0007338)2.84185466
110skeletal muscle contraction (GO:0003009)2.82328711
111positive regulation of keratinocyte differentiation (GO:0045618)2.81781044
112formation of translation preinitiation complex (GO:0001731)2.80801123
113cellular component biogenesis (GO:0044085)2.79117967
114positive regulation of DNA-dependent DNA replication (GO:2000105)2.78852495
115deoxyribonucleotide metabolic process (GO:0009262)2.77161223
116protein kinase C signaling (GO:0070528)2.76216091
117purine nucleoside diphosphate metabolic process (GO:0009135)2.76113217
118purine ribonucleoside diphosphate metabolic process (GO:0009179)2.76113217
119pyrimidine nucleotide catabolic process (GO:0006244)2.75865473
120regulation of penile erection (GO:0060405)2.75585672
121regulation of necrotic cell death (GO:0010939)2.74020368
122pyrimidine deoxyribonucleotide metabolic process (GO:0009219)2.72694442
123desmosome organization (GO:0002934)2.72531652
124positive regulation of interleukin-17 production (GO:0032740)2.71539470
125male meiosis (GO:0007140)2.69061771
126meiosis I (GO:0007127)2.67763047
127DNA damage response, detection of DNA damage (GO:0042769)2.66910418
128maintenance of protein location in nucleus (GO:0051457)2.66393064
129sphingoid metabolic process (GO:0046519)2.65716238
130actin-mediated cell contraction (GO:0070252)2.64170805
131positive regulation of digestive system process (GO:0060456)2.64026089
132meiotic cell cycle (GO:0051321)2.63625610
133valine metabolic process (GO:0006573)2.62343101
134rRNA processing (GO:0006364)2.60795890
135DNA damage response, signal transduction by p53 class mediator resulting in transcription of p21 cla2.60216763
136negative regulation of telomere maintenance (GO:0032205)2.59832331
137* negative regulation of epidermal cell differentiation (GO:0045605)2.59378377
138positive regulation of activated T cell proliferation (GO:0042104)2.58312121
139fucose catabolic process (GO:0019317)2.58192611
140L-fucose metabolic process (GO:0042354)2.58192611
141L-fucose catabolic process (GO:0042355)2.58192611
142positive regulation of protein deacetylation (GO:0090312)2.57910791
143meiotic nuclear division (GO:0007126)2.57747379
144positive regulation of receptor biosynthetic process (GO:0010870)2.57606883
145negative regulation of G2/M transition of mitotic cell cycle (GO:0010972)2.57077144
146ribosome biogenesis (GO:0042254)2.55801367
147poly(A)+ mRNA export from nucleus (GO:0016973)2.54343131
148positive regulation of defense response to virus by host (GO:0002230)2.54300687
149ketone body metabolic process (GO:1902224)2.53814432
150rRNA metabolic process (GO:0016072)2.53547036
151establishment of protein localization to membrane (GO:0090150)2.52562520
152DNA replication initiation (GO:0006270)2.52554739
153phospholipid scrambling (GO:0017121)2.52451922
154pattern specification involved in kidney development (GO:0061004)2.52006691
155autophagic vacuole fusion (GO:0000046)2.51799183
156short-chain fatty acid metabolic process (GO:0046459)2.51560866
157interferon-gamma production (GO:0032609)2.50687483
158DNA damage response, signal transduction resulting in transcription (GO:0042772)2.49581111
1593-UTR-mediated mRNA stabilization (GO:0070935)2.49390185
160regulation of necroptotic process (GO:0060544)2.47768837
161negative regulation of telomerase activity (GO:0051974)2.47628122
162histone H4-K12 acetylation (GO:0043983)2.47618843
163cellular metabolic compound salvage (GO:0043094)2.47488862
164purine nucleobase metabolic process (GO:0006144)2.47180018
165skeletal muscle tissue regeneration (GO:0043403)2.47109307
166response to muscle activity (GO:0014850)2.46926344
167telomere maintenance via semi-conservative replication (GO:0032201)2.46337375
168positive regulation of CD4-positive, alpha-beta T cell activation (GO:2000516)2.46258479
169maternal behavior (GO:0042711)2.43517247
170L-methionine biosynthetic process from methylthioadenosine (GO:0019509)2.43274931
171synaptonemal complex assembly (GO:0007130)2.42538176
172regulation of cell proliferation involved in kidney development (GO:1901722)2.42150631
173vesicle fusion (GO:0006906)2.40949293
174female gamete generation (GO:0007292)2.40611074
175negative regulation of necroptotic process (GO:0060546)2.39419324
176chromosome organization involved in meiosis (GO:0070192)2.39294304
177DNA strand elongation involved in DNA replication (GO:0006271)2.38972003
178gene silencing by RNA (GO:0031047)2.37719820
179negative regulation of transcription elongation from RNA polymerase II promoter (GO:0034244)2.37637560
180hematopoietic stem cell proliferation (GO:0071425)2.37551439
181positive regulation of CD4-positive, alpha-beta T cell differentiation (GO:0043372)2.37384832
182regulation of respiratory burst (GO:0060263)2.36394197
183hemidesmosome assembly (GO:0031581)2.35961268
184regulation of antigen processing and presentation of peptide antigen (GO:0002583)2.34804847
185mitochondrial DNA replication (GO:0006264)2.34763518
186mitotic chromosome condensation (GO:0007076)2.33726667
187cytidine metabolic process (GO:0046087)2.32745790
188cytidine catabolic process (GO:0006216)2.32745790
189cytidine deamination (GO:0009972)2.32745790
190cellular hyperosmotic response (GO:0071474)2.32414058
191rRNA methylation (GO:0031167)2.31293087
192activation of transmembrane receptor protein tyrosine kinase activity (GO:0007171)2.30512673
193positive regulation of B cell differentiation (GO:0045579)2.29026845
194regulation of hair follicle development (GO:0051797)2.29008600

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1TP63_17297297_ChIP-ChIP_HaCaT_Human5.53073073
2E2F7_22180533_ChIP-Seq_HELA_Human5.32643206
3BP1_19119308_ChIP-ChIP_Hs578T_Human4.03236723
4NOTCH1_17114293_ChIP-ChIP_T-ALL_Human3.51773090
5MYC_18555785_ChIP-Seq_MESCs_Mouse3.32228827
6SCL_19346495_ChIP-Seq_HPC-7_Human3.20801138
7KLF2_18264089_ChIP-ChIP_MESCs_Mouse2.96083341
8KLF5_18264089_ChIP-ChIP_MESCs_Mouse2.96083341
9KLF4_18264089_ChIP-ChIP_MESCs_Mouse2.96083341
10EKLF_21900194_ChIP-Seq_ERYTHROCYTE_Mouse2.92101060
11MYBL1_21750041_ChIP-ChIP_SPERMATOCYTES_Mouse2.88093297
12PRDM16_22522345_ChIP-ChIP_PALATE_MESENCHYMAL_Mouse2.81968012
13TP63_19390658_ChIP-ChIP_HaCaT_Human2.59728938
14FOXM1_25889361_ChIP-Seq_OE33_AND_U2OS_Human2.58632502
15TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat2.47968980
16EZH2_22144423_ChIP-Seq_EOC_Human2.38220013
17ELF1_17652178_ChIP-ChIP_JURKAT_Human2.38187961
18SOX9_22984422_ChIP-ChIP_TESTIS_Rat2.30178252
19E2F4_17652178_ChIP-ChIP_JURKAT_Human2.26725165
20SPI1_22790984_ChIP-Seq_ERYTHROLEUKEMIA_Mouse2.26222948
21TRP63_18441228_ChIP-ChIP_KERATINOCYTES_Mouse2.25428159
22MYC_19079543_ChIP-ChIP_MESCs_Mouse2.20397887
23MYC_18358816_ChIP-ChIP_MESCs_Mouse2.05892847
24E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse2.05861145
25HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse2.02208727
26EGR1_19374776_ChIP-ChIP_THP-1_Human2.02035163
27RUNX1_20887958_ChIP-Seq_HPC-7_Mouse1.93198824
28MYC_22102868_ChIP-Seq_BL_Human1.90325118
29VDR_21846776_ChIP-Seq_THP-1_Human1.90018938
30* CHD7_19251738_ChIP-ChIP_MESCs_Mouse1.89959250
31EST1_17652178_ChIP-ChIP_JURKAT_Human1.88411046
32MYC_19030024_ChIP-ChIP_MESCs_Mouse1.84497410
33TAL1_20887958_ChIP-Seq_HPC-7_Mouse1.80670704
34XRN2_22483619_ChIP-Seq_HELA_Human1.79466393
35TET1_21451524_ChIP-Seq_MESCs_Mouse1.78853990
36* BCL3_23251550_ChIP-Seq_MUSCLE_Mouse1.78675831
37CHD1_19587682_ChIP-ChIP_MESCs_Mouse1.78479881
38CREB1_15753290_ChIP-ChIP_HEK293T_Human1.77702724
39KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human1.75606018
40FOXM1_23109430_ChIP-Seq_U2OS_Human1.73801252
41ZNF263_19887448_ChIP-Seq_K562_Human1.72116747
42NOTCH1_21737748_ChIP-Seq_TLL_Human1.70412495
43HCFC1_20581084_ChIP-Seq_MESCs_Mouse1.68263831
44* BCL6_27268052_Chip-Seq_Bcells_Human1.67412830
45GABP_17652178_ChIP-ChIP_JURKAT_Human1.66311145
46TTF2_22483619_ChIP-Seq_HELA_Human1.65439871
47FLI1_20887958_ChIP-Seq_HPC-7_Mouse1.62045427
48* CTCF_26484167_Chip-Seq_Bcells_Mouse1.59957126
49SPI1_23547873_ChIP-Seq_NB4_Human1.59036152
50CEBPB_24764292_ChIP-Seq_MC3T3_Mouse1.58130209
51ETS1_20019798_ChIP-Seq_JURKAT_Human1.54260423
52MYB_21317192_ChIP-Seq_ERMYB_Mouse1.53389198
53MECOM_23826213_ChIP-Seq_KASUMI_Mouse1.48666731
54* KLF4_18358816_ChIP-ChIP_MESCs_Mouse1.47517680
55ERG_20887958_ChIP-Seq_HPC-7_Mouse1.45531596
56VDR_23849224_ChIP-Seq_CD4+_Human1.45510448
57JARID1A_20064375_ChIP-Seq_MESCs_Mouse1.45248301
58FOXP3_21729870_ChIP-Seq_TREG_Human1.44807654
59RUNX1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.44329406
60CDX2_20551321_ChIP-Seq_CACO-2_Human1.43876392
61P68_20966046_ChIP-Seq_HELA_Human1.42528904
62ELF1_20517297_ChIP-Seq_JURKAT_Human1.41035238
63* TCF7_22412390_ChIP-Seq_EML_Mouse1.39818028
64E2F1_18555785_ChIP-Seq_MESCs_Mouse1.38118586
65CIITA_18437201_ChIP-ChIP_Raji_B_and_iDC_Human1.36458598
66HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human1.34420271
67STAT1_20625510_ChIP-Seq_HELA_Human1.32354443
68* MYBL2_22936984_ChIP-ChIP_MESCs_Mouse1.32147307
69HOXB4_20404135_ChIP-ChIP_EML_Mouse1.31122468
70IRF1_21803131_ChIP-Seq_MONOCYTES_Human1.27491703
71SFPI1_20887958_ChIP-Seq_HPC-7_Mouse1.27266385
72BCOR_27268052_Chip-Seq_Bcells_Human1.25399056
73RUNX1_22412390_ChIP-Seq_EML_Mouse1.24156640
74PDX1_19855005_ChIP-ChIP_MIN6_Mouse1.23795773
75IRF8_22096565_ChIP-ChIP_GC-B_Mouse1.23299424
76KLF4_19030024_ChIP-ChIP_MESCs_Mouse1.22888061
77ZNF652_21678463_ChIP-ChIP_ZR75-1_Human1.22395333
78STAT3_1855785_ChIP-Seq_MESCs_Mouse1.22020168
79SPI1_22096565_ChIP-ChIP_GC-B_Mouse1.21770433
80CTCF_21964334_ChIP-Seq_BJAB-B_Human1.20983000
81THAP11_20581084_ChIP-Seq_MESCs_Mouse1.18759589
82SREBP2_21459322_ChIP-Seq_LIVER_Mouse1.18708873
83CIITA_25753668_ChIP-Seq_RAJI_Human1.18631100
84NELFA_20434984_ChIP-Seq_ESCs_Mouse1.18358208
85MYB_26560356_Chip-Seq_TH2_Human1.17781595
86TP53_20018659_ChIP-ChIP_R1E_Mouse1.16694385
87ESR1_15608294_ChIP-ChIP_MCF-7_Human1.15451489
88* NANOG_20526341_ChIP-Seq_ESCs_Human1.14070622
89ASXL1_24218140_ChIP-Seq_BMDM_Mouse1.13736947
90GATA2_22383799_ChIP-Seq_G1ME_Mouse1.13731872
91YY1_21170310_ChIP-Seq_MESCs_Mouse1.13264038
92ELK1_19687146_ChIP-ChIP_HELA_Human1.12222840
93P300_27268052_Chip-Seq_Bcells_Human1.11834914
94ELK3_25401928_ChIP-Seq_HUVEC_Human1.10765354
95LYL1_20887958_ChIP-Seq_HPC-7_Mouse1.10524554
96ZFX_18555785_ChIP-Seq_MESCs_Mouse1.10385340
97DCP1A_22483619_ChIP-Seq_HELA_Human1.08784087
98DACH1_20351289_ChIP-Seq_MDA-MB-231_Human1.08641751
99AR_21909140_ChIP-Seq_LNCAP_Human1.07718863
100ELK1_22589737_ChIP-Seq_MCF10A_Human1.07428014
101STAT6_21828071_ChIP-Seq_BEAS2B_Human1.07110671
102TAF7L_23326641_ChIP-Seq_C3H10T1-2_Mouse1.06394830
103LMO2_20887958_ChIP-Seq_HPC-7_Mouse1.05322849
104RAC3_21632823_ChIP-Seq_H3396_Human1.04461619
105TCF3_18692474_ChIP-Seq_MEFs_Mouse1.02222541
106GATA1_22383799_ChIP-Seq_G1ME_Mouse1.02192815
107ETS1_21867929_ChIP-Seq_TH2_Mouse1.01441060
108POU5F1_18700969_ChIP-ChIP_MESCs_Mouse1.00344849
109VDR_24763502_ChIP-Seq_THP-1_Human1.00179202
110* SPI1_20517297_ChIP-Seq_HL60_Human0.98992969
111* P63_26484246_Chip-Seq_KERATINOCYTES_Human0.98941006
112* UTX_26944678_Chip-Seq_JUKART_Human0.98938860
113GABP_19822575_ChIP-Seq_HepG2_Human0.98367168
114E2F1_20622854_ChIP-Seq_HELA_Human0.97791127
115SMC3_22415368_ChIP-Seq_MEFs_Mouse0.97548664
116CTCF_18555785_ChIP-Seq_MESCs_Mouse0.97111148
117SRF_21415370_ChIP-Seq_HL-1_Mouse0.97004388
118MAF_26560356_Chip-Seq_TH1_Human0.95945294
119MYCN_21190229_ChIP-Seq_SHEP-21N_Human0.94910065
120YY1_22570637_ChIP-Seq_MALME-3M_Human0.94754477
121POU5F1_18358816_ChIP-ChIP_MESCs_Mouse0.94682049
122RAD21_21589869_ChIP-Seq_MESCs_Mouse0.94484869
123FOXO3_22982991_ChIP-Seq_MACROPHAGES_Mouse0.94079321
124GFI1B_20887958_ChIP-Seq_HPC-7_Mouse0.92903800
125ESR1_21235772_ChIP-Seq_MCF-7_Human0.92761277
126CNOT3_19339689_ChIP-ChIP_MESCs_Mouse0.91752430
127NR1H3_23393188_ChIP-Seq_ATHEROSCLEROTIC-FOAM_Human0.90818192
128E2F1_21310950_ChIP-Seq_MCF-7_Human0.89967738
129KLF4_18555785_ChIP-Seq_MESCs_Mouse0.89896372
130CTCF_21964334_Chip-Seq_Bcells_Human0.89724325
131* SA1_22415368_ChIP-Seq_MEFs_Mouse0.88963551
132MYC_18940864_ChIP-ChIP_HL60_Human0.88679877
133* TBP_23326641_ChIP-Seq_C3H10T1-2_Mouse0.88308863
134PPARG_19300518_ChIP-PET_3T3-L1_Mouse0.88175221
135HIF1A_21447827_ChIP-Seq_MCF-7_Human0.87619867
136* MEIS1_20887958_ChIP-Seq_HPC-7_Mouse0.87382776
137POU5F1_18555785_ChIP-Seq_MESCs_Mouse0.87062704
138PPARG_23326641_ChIP-Seq_C3H10T1-2_Mouse0.86555941
139IRF8_22096565_ChIP-ChIP_GC-B_Human0.85654070
140BRD4_27068464_Chip-Seq_AML-cells_Mouse0.85278156
141TBX5_21415370_ChIP-Seq_HL-1_Mouse0.84230098
142TAF2_19829295_ChIP-Seq_ESCs_Human0.83817208
143TP63_22573176_ChIP-Seq_HFKS_Human0.82929783
144PU.1_20513432_ChIP-Seq_MACROPHAGES_Mouse0.82848339

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0002396_abnormal_hematopoietic_system3.81503907
2MP0003718_maternal_effect3.48592251
3MP0003806_abnormal_nucleotide_metabolis3.41774610
4MP0004381_abnormal_hair_follicle3.04308684
5MP0005075_abnormal_melanosome_morpholog2.88070003
6MP0002160_abnormal_reproductive_system2.81975827
7MP0002234_abnormal_pharynx_morphology2.80340867
8MP0003011_delayed_dark_adaptation2.79222282
9MP0000681_abnormal_thyroid_gland2.54816470
10MP0002796_impaired_skin_barrier2.48816491
11MP0001188_hyperpigmentation2.47596854
12MP0000013_abnormal_adipose_tissue2.27482040
13MP0009379_abnormal_foot_pigmentation2.24710731
14MP0000383_abnormal_hair_follicle2.24202778
15MP0004957_abnormal_blastocyst_morpholog2.20778811
16MP0004782_abnormal_surfactant_physiolog2.20019762
17MP0006036_abnormal_mitochondrial_physio2.16231739
18MP0003315_abnormal_perineum_morphology2.15593304
19MP0002254_reproductive_system_inflammat2.11774140
20MP0002132_abnormal_respiratory_system2.09788274
21MP0006292_abnormal_olfactory_placode2.09115289
22MP0000490_abnormal_crypts_of2.08743330
23MP0002249_abnormal_larynx_morphology2.07709601
24MP0002108_abnormal_muscle_morphology2.04327680
25MP0000749_muscle_degeneration2.03160223
26MP0001664_abnormal_digestion1.98396326
27MP0004264_abnormal_extraembryonic_tissu1.95044380
28MP0005501_abnormal_skin_physiology1.90945891
29MP0000003_abnormal_adipose_tissue1.88587021
30MP0010030_abnormal_orbit_morphology1.85526065
31MP0003693_abnormal_embryo_hatching1.83011782
32MP0010352_gastrointestinal_tract_polyps1.79512902
33MP0005503_abnormal_tendon_morphology1.78079804
34MP0000372_irregular_coat_pigmentation1.76464592
35MP0004145_abnormal_muscle_electrophysio1.75678419
36MP0003941_abnormal_skin_development1.75238080
37MP0009697_abnormal_copulation1.72248357
38MP0000678_abnormal_parathyroid_gland1.72151828
39MP0005397_hematopoietic_system_phenotyp1.70313568
40MP0001545_abnormal_hematopoietic_system1.70313568
41MP0003938_abnormal_ear_development1.70225407
42MP0000465_gastrointestinal_hemorrhage1.69460375
43MP0004808_abnormal_hematopoietic_stem1.67193667
44MP0000762_abnormal_tongue_morphology1.66266866
45MP0000759_abnormal_skeletal_muscle1.66130928
46MP0009250_abnormal_appendicular_skeleto1.65807607
47MP0010094_abnormal_chromosome_stability1.65099718
48MP0003646_muscle_fatigue1.64689879
49MP0001764_abnormal_homeostasis1.61303300
50MP0004233_abnormal_muscle_weight1.56965154
51MP0005389_reproductive_system_phenotype1.56936182
52MP0008007_abnormal_cellular_replicative1.55930586
53MP0002098_abnormal_vibrissa_morphology1.54657008
54MP0003950_abnormal_plasma_membrane1.49205686
55MP0005360_urolithiasis1.49076558
56MP0003077_abnormal_cell_cycle1.47004901
57MP0000751_myopathy1.46336360
58MP0002060_abnormal_skin_morphology1.46155892
59MP0005395_other_phenotype1.46082557
60MP0001661_extended_life_span1.45321251
61MP0001216_abnormal_epidermal_layer1.44919761
62MP0004036_abnormal_muscle_relaxation1.42117952
63MP0008057_abnormal_DNA_replication1.37820057
64MP0000733_abnormal_muscle_development1.37274142
65MP0000377_abnormal_hair_follicle1.36712480
66MP0002932_abnormal_joint_morphology1.35698931
67MP0002009_preneoplasia1.35065785
68MP0000049_abnormal_middle_ear1.33458134
69MP0002138_abnormal_hepatobiliary_system1.32928859
70MP0002277_abnormal_respiratory_mucosa1.28754601
71MP0005275_abnormal_skin_tensile1.28365443
72MP0005646_abnormal_pituitary_gland1.25070047
73MP0008932_abnormal_embryonic_tissue1.24666366
74MP0008877_abnormal_DNA_methylation1.24417996
75MP0005330_cardiomyopathy1.23507096
76MP0010678_abnormal_skin_adnexa1.23027638
77MP0003763_abnormal_thymus_physiology1.22848356
78MP0005410_abnormal_fertilization1.22305666
79MP0003045_fibrosis1.21793215
80MP0001849_ear_inflammation1.20101699
81MP0005369_muscle_phenotype1.19975694
82MP0010771_integument_phenotype1.19659512
83MP0001270_distended_abdomen1.16415928
84MP0000747_muscle_weakness1.16063755
85MP0003111_abnormal_nucleus_morphology1.10506127
86MP0003942_abnormal_urinary_system1.09826004
87MP0002095_abnormal_skin_pigmentation1.09263447
88MP0001929_abnormal_gametogenesis1.08400839
89MP0002127_abnormal_cardiovascular_syste1.04719889
90MP0004087_abnormal_muscle_fiber1.04288233
91MP0005023_abnormal_wound_healing1.03959270
92MP0005058_abnormal_lysosome_morphology1.02996193
93MP0008058_abnormal_DNA_repair1.02041730
94MP0001881_abnormal_mammary_gland1.01878611
95MP0005499_abnormal_olfactory_system1.01740763
96MP0005394_taste/olfaction_phenotype1.01740763
97* MP0002114_abnormal_axial_skeleton1.00928563
98MP0004858_abnormal_nervous_system1.00863572
99MP0002019_abnormal_tumor_incidence1.00664559
100MP0003453_abnormal_keratinocyte_physiol1.00483314
101MP0005508_abnormal_skeleton_morphology0.99395776
102MP0008789_abnormal_olfactory_epithelium0.98709316
103MP0010368_abnormal_lymphatic_system0.98653908
104MP0002166_altered_tumor_susceptibility0.96161617
105MP0002233_abnormal_nose_morphology0.96029050
106MP0001835_abnormal_antigen_presentation0.95963485
107MP0003136_yellow_coat_color0.95343964
108MP0005174_abnormal_tail_pigmentation0.95065537
109MP0005375_adipose_tissue_phenotype0.94672468
110MP0004043_abnormal_pH_regulation0.94297118
111MP0002006_tumorigenesis0.92602584
112MP0002398_abnormal_bone_marrow0.92480885
113MP0002269_muscular_atrophy0.92302223
114* MP0002722_abnormal_immune_system0.91536971
115MP0000350_abnormal_cell_proliferation0.91529823
116MP0002109_abnormal_limb_morphology0.91512192
117MP0002106_abnormal_muscle_physiology0.91223658
118MP0001879_abnormal_lymphatic_vessel0.90718345
119MP0000858_altered_metastatic_potential0.90560814
120MP0002282_abnormal_trachea_morphology0.90538010
121MP0010155_abnormal_intestine_physiology0.90310782
122MP0003705_abnormal_hypodermis_morpholog0.90197083
123MP0000467_abnormal_esophagus_morphology0.90072077
124MP0002210_abnormal_sex_determination0.89713664
125MP0003279_aneurysm0.88775136
126MP0009931_abnormal_skin_appearance0.87933294
127MP0003566_abnormal_cell_adhesion0.87801897
128MP0009278_abnormal_bone_marrow0.86927423
129MP0005464_abnormal_platelet_physiology0.86066920
130MP0000689_abnormal_spleen_morphology0.85145138
131MP0005409_darkened_coat_color0.84993933
132MP0002876_abnormal_thyroid_physiology0.84770206
133MP0000647_abnormal_sebaceous_gland0.84583851
134MP0000653_abnormal_sex_gland0.83856251
135MP0002877_abnormal_melanocyte_morpholog0.82688584
136MP0003385_abnormal_body_wall0.80520510
137MP0008961_abnormal_basal_metabolism0.79995786
138MP0005257_abnormal_intraocular_pressure0.79872702
139MP0000750_abnormal_muscle_regeneration0.78666809
140MP0000163_abnormal_cartilage_morphology0.78009012
141MP0003828_pulmonary_edema0.77884258
142MP0002429_abnormal_blood_cell0.77757069
143MP0002938_white_spotting0.77545239
144MP0003724_increased_susceptibility_to0.77542002
145MP0005670_abnormal_white_adipose0.76784232
146MP0000477_abnormal_intestine_morphology0.76456946
147MP0003959_abnormal_lean_body0.76387067
148MP0000613_abnormal_salivary_gland0.75999683
149MP0003436_decreased_susceptibility_to0.75253429
150MP0003786_premature_aging0.74942324
151MP0005620_abnormal_muscle_contractility0.73258837
152MP0002751_abnormal_autonomic_nervous0.72848655
153MP0000685_abnormal_immune_system0.72743412
154MP0006054_spinal_hemorrhage0.72686173
155MP0001145_abnormal_male_reproductive0.72058906
156MP0003755_abnormal_palate_morphology0.71832780
157MP0001191_abnormal_skin_condition0.71820855
158MP0000313_abnormal_cell_death0.71655982
159MP0003866_abnormal_defecation0.71552134
160MP0001853_heart_inflammation0.71130132
161MP0000427_abnormal_hair_cycle0.70220999
162MP0005025_abnormal_response_to0.69951349
163MP0003183_abnormal_peptide_metabolism0.69819237
164MP0003698_abnormal_male_reproductive0.68248915
165MP0004084_abnormal_cardiac_muscle0.67321681
166MP0000462_abnormal_digestive_system0.66936426
167MP0003699_abnormal_female_reproductive0.66919724
168MP0008004_abnormal_stomach_pH0.66010397
169MP0003879_abnormal_hair_cell0.65258753
170MP0009333_abnormal_splenocyte_physiolog0.65075499
171MP0002148_abnormal_hypersensitivity_rea0.64519668
172MP0001119_abnormal_female_reproductive0.61669584

Predicted human phenotypes

RankGene SetZ-score
1Aplastic anemia (HP:0001915)5.66167156
2Abnormality of cells of the erythroid lineage (HP:0012130)5.35582655
3Muscle fiber inclusion bodies (HP:0100299)5.19236944
4Muscle fiber cytoplasmatic inclusion bodies (HP:0100303)5.13445351
5Nemaline bodies (HP:0003798)4.96678202
6Reticulocytopenia (HP:0001896)4.96074592
7Abnormal number of erythroid precursors (HP:0012131)4.90478007
8Exercise-induced myalgia (HP:0003738)4.88611431
9Distal arthrogryposis (HP:0005684)4.19873858
10Muscle stiffness (HP:0003552)3.92873572
11Centrally nucleated skeletal muscle fibers (HP:0003687)3.81590007
12Abnormal hemoglobin (HP:0011902)3.66220239
13Aplasia/Hypoplasia of the sacrum (HP:0008517)3.64444158
14Type 1 muscle fiber predominance (HP:0003803)3.63678038
15Pallor (HP:0000980)3.60802480
16Type 2 muscle fiber atrophy (HP:0003554)3.54934005
17Decreased activity of mitochondrial respiratory chain (HP:0008972)3.40110323
18Abnormal activity of mitochondrial respiratory chain (HP:0011922)3.40110323
19Macrocytic anemia (HP:0001972)3.36352111
20Neck muscle weakness (HP:0000467)3.32732022
21Thrombocytosis (HP:0001894)3.31971534
22Rhabdomyolysis (HP:0003201)3.31837224
23Bilateral microphthalmos (HP:0007633)3.30575679
24Absent phalangeal crease (HP:0006109)3.30573215
25Elevated erythrocyte sedimentation rate (HP:0003565)3.29185597
26Reduced antithrombin III activity (HP:0001976)3.28336844
27Nasolacrimal duct obstruction (HP:0000579)3.21183150
28Concave nail (HP:0001598)3.12185667
29Lip pit (HP:0100267)3.02101426
30Partial duplication of thumb phalanx (HP:0009944)3.01273782
31Rimmed vacuoles (HP:0003805)3.00059606
32Dicarboxylic aciduria (HP:0003215)2.94707256
33Abnormality of dicarboxylic acid metabolism (HP:0010995)2.94707256
34Petechiae (HP:0000967)2.93547224
35EMG: myopathic abnormalities (HP:0003458)2.92893408
36Abnormal isoelectric focusing of serum transferrin (HP:0003160)2.92491946
37Popliteal pterygium (HP:0009756)2.91806186
38Partial duplication of the phalanx of hand (HP:0009999)2.89681058
39Bulbar palsy (HP:0001283)2.78082177
40Myopathic facies (HP:0002058)2.74473296
41Abnormality of skeletal muscle fiber size (HP:0012084)2.72787509
42Malignant hyperthermia (HP:0002047)2.72488589
43Hypotrichosis (HP:0001006)2.70933971
44Chromsome breakage (HP:0040012)2.70625150
45Sparse eyelashes (HP:0000653)2.70351686
46Muscle fiber splitting (HP:0003555)2.70015516
47Microretrognathia (HP:0000308)2.66755922
48Multiple enchondromatosis (HP:0005701)2.66481476
49Spinal rigidity (HP:0003306)2.64952844
50Increased muscle lipid content (HP:0009058)2.63180231
51Abnormality of placental membranes (HP:0011409)2.62173638
52Amniotic constriction ring (HP:0009775)2.62173638
53Abnormal lung lobation (HP:0002101)2.62015969
54Type I transferrin isoform profile (HP:0003642)2.61088294
55Bundle branch block (HP:0011710)2.57835816
56Chromosomal breakage induced by crosslinking agents (HP:0003221)2.57704877
57Nephroblastoma (Wilms tumor) (HP:0002667)2.55097448
58Aplasia of the musculature (HP:0100854)2.54829610
59Hyporeflexia of lower limbs (HP:0002600)2.54758058
60Abnormal finger flexion creases (HP:0006143)2.51678313
61Rib fusion (HP:0000902)2.51211746
62Myoglobinuria (HP:0002913)2.48632082
63Myositis (HP:0100614)2.48515572
64Severe combined immunodeficiency (HP:0004430)2.46690215
65B lymphocytopenia (HP:0010976)2.44702642
66Absent rod-and cone-mediated responses on ERG (HP:0007688)2.44491467
67Increased variability in muscle fiber diameter (HP:0003557)2.39247237
68Rhabdomyosarcoma (HP:0002859)2.37345895
69Asymmetric septal hypertrophy (HP:0001670)2.35910094
70Agammaglobulinemia (HP:0004432)2.34778573
71Abnormality of the lacrimal duct (HP:0011481)2.33439114
72Methylmalonic aciduria (HP:0012120)2.33276142
73Embryonal renal neoplasm (HP:0011794)2.32985559
74Abnormality of the phalanges of the hallux (HP:0010057)2.32140269
75Round ear (HP:0100830)2.30949772
76Posterior subcapsular cataract (HP:0007787)2.30733622
77Aplasia/Hypoplasia of the thymus (HP:0010515)2.30326131
78Down-sloping shoulders (HP:0200021)2.28281279
79Granulocytopenia (HP:0001913)2.27008229
80Myelodysplasia (HP:0002863)2.24798885
81Unsteady gait (HP:0002317)2.22235835
82Symphalangism affecting the phalanges of the hand (HP:0009773)2.20470370
83Abnormality of the prostate (HP:0008775)2.19203909
84Myotonia (HP:0002486)2.18971774
85Metaphyseal dysplasia (HP:0100255)2.18508325
86Anterior segment dysgenesis (HP:0007700)2.17036776
87Abnormality of B cell number (HP:0010975)2.16053115
88Erythema (HP:0010783)2.15818740
89Exercise-induced muscle cramps (HP:0003710)2.15325202
90Meckel diverticulum (HP:0002245)2.15247379
91Progressive muscle weakness (HP:0003323)2.15061188
92Scapular winging (HP:0003691)2.14929754
93Mesangial abnormality (HP:0001966)2.13785282
94IgM deficiency (HP:0002850)2.12110557
95Increased intramyocellular lipid droplets (HP:0012240)2.11432792
96Male infertility (HP:0003251)2.10408818
97Decreased activity of cytochrome C oxidase in muscle tissue (HP:0003688)2.10323263
983-Methylglutaconic aciduria (HP:0003535)2.09400372
99Fatigable weakness (HP:0003473)2.08937536
100Abnormality of the neuromuscular junction (HP:0003398)2.08937536
101Colon cancer (HP:0003003)2.08714291
102Gowers sign (HP:0003391)2.06649373
103Radial bowing (HP:0002986)2.06515094
104Abnormality of the ileum (HP:0001549)2.05014368
105Increased IgE level (HP:0003212)2.03990389
106Hepatoblastoma (HP:0002884)2.03935741
107Aplasia/Hypoplasia involving the musculature (HP:0001460)2.03122420
108Ulnar deviation of the wrist (HP:0003049)2.02385459
109Muscle hypertrophy of the lower extremities (HP:0008968)2.01935794
110Pancytopenia (HP:0001876)2.01819467
111Abnormality of the nasolacrimal system (HP:0000614)2.01798750
112Muscle fiber atrophy (HP:0100295)2.01077277
113Muscle abnormality related to mitochondrial dysfunction (HP:0003800)1.99765516
114Sensory axonal neuropathy (HP:0003390)1.99587521
115Abnormality of the shoulder girdle musculature (HP:0001435)1.96644479
116Abnormality of the preputium (HP:0100587)1.96065918
117Neoplasm of striated muscle (HP:0009728)1.96021211
118Abnormality of hair growth rate (HP:0011363)1.95321531
119Slow-growing hair (HP:0002217)1.95321531
120Acute myeloid leukemia (HP:0004808)1.93228429
121Fetal akinesia sequence (HP:0001989)1.90602993
122Heart block (HP:0012722)1.90303173
123Abnormality of the salivary glands (HP:0010286)1.89951314
124Abnormality of the heme biosynthetic pathway (HP:0010472)1.89947626
125Abnormality of the columella (HP:0009929)1.88382188
126Woolly hair (HP:0002224)1.88093496
127Combined immunodeficiency (HP:0005387)1.87681234
128Easy fatigability (HP:0003388)1.87309449
129Respiratory insufficiency due to muscle weakness (HP:0002747)1.85483436
130Hypochromic anemia (HP:0001931)1.85342605
131Acute lymphatic leukemia (HP:0006721)1.84562370
132Ragged-red muscle fibers (HP:0003200)1.84371303
133Abnormal atrioventricular conduction (HP:0005150)1.84149063
134Hip contracture (HP:0003273)1.83801092
135Atresia of the external auditory canal (HP:0000413)1.83593451
136Abnormality of the axillary hair (HP:0100134)1.82457859
137Abnormality of secondary sexual hair (HP:0009888)1.82457859
138Trismus (HP:0000211)1.81175612
139Facial diplegia (HP:0001349)1.80736965
140Abnormality of the anterior chamber (HP:0000593)1.78622422
141Eosinophilia (HP:0001880)1.78417557
142Hypophosphatemic rickets (HP:0004912)1.78152159
143Thin bony cortex (HP:0002753)1.76874471
144Depressed nasal ridge (HP:0000457)1.76830498
145Nonprogressive disorder (HP:0003680)1.76830263
146Chronic otitis media (HP:0000389)1.76567437
147Methylmalonic acidemia (HP:0002912)1.75775822
148Nonimmune hydrops fetalis (HP:0001790)1.75384477
149Hypochromic microcytic anemia (HP:0004840)1.75250917
150Patchy hypopigmentation of hair (HP:0011365)1.75192059
151Abnormality of the distal phalanx of the thumb (HP:0009617)1.74576493
152Calcaneovalgus deformity (HP:0001848)1.74485120
153Abnormality of fatty-acid metabolism (HP:0004359)1.74253386
154Short middle phalanx of the 5th finger (HP:0004220)1.71884030
155Shawl scrotum (HP:0000049)1.71720045
156Deformed tarsal bones (HP:0008119)1.70976152
157Fragile nails (HP:0001808)1.70937232
158Respiratory difficulties (HP:0002880)1.70900468
159Nasal polyposis (HP:0100582)1.68390269
160Triphalangeal thumb (HP:0001199)1.67693058
161Anomalous pulmonary venous return (HP:0010772)1.66185412
162Conical tooth (HP:0000698)1.64120978
163Aplasia/Hypoplasia of the spleen (HP:0010451)1.62928983
164Abnormality of the nasal mucosa (HP:0000433)1.61904392
165Duplication of thumb phalanx (HP:0009942)1.61873492
166Premature ovarian failure (HP:0008209)1.61206565
167Abnormality of the parietal bone (HP:0002696)1.61119047
168Weak cry (HP:0001612)1.61107282
169White forelock (HP:0002211)1.60684004
170Episodic fever (HP:0001954)1.59921993
171Renal Fanconi syndrome (HP:0001994)1.59182558
172Asplenia (HP:0001746)1.58847174
173Short 5th finger (HP:0009237)1.57598070
174Abnormality of T cell physiology (HP:0011840)1.57413119
175Testicular atrophy (HP:0000029)1.57400123
176Flared metaphyses (HP:0003015)1.57229290
177Preauricular skin tag (HP:0000384)1.56804618
178Pili torti (HP:0003777)1.56444812
179Pendular nystagmus (HP:0012043)1.56301393
180Abnormal protein N-linked glycosylation (HP:0012347)1.55846883
181Abnormal protein glycosylation (HP:0012346)1.55846883
182Abnormal glycosylation (HP:0012345)1.55846883

Predicted kinase interactions (KEA)

RankGene SetZ-score
1BCKDK3.96276507
2OBSCN3.31536269
3VRK23.11848088
4ARAF2.97374957
5MAP3K132.92958416
6GRK52.91124132
7CDK122.86602910
8PIM22.76995705
9KIT2.72529438
10ERN12.68704562
11EEF2K2.61155486
12KDR2.59930111
13CSF1R2.56942290
14PINK12.51031666
15TGFBR22.42294451
16NME22.32167829
17MATK2.29946867
18MAPKAPK32.25261689
19MAP2K32.21899988
20ADRBK22.20938365
21TAOK32.20855156
22TLK12.10894885
23GRK62.09004356
24STK102.04727479
25FLT31.95321038
26MOS1.94948907
27RPS6KB21.92850042
28TEC1.91623334
29CDK71.76392202
30CDK81.75650646
31BTK1.70161618
32BRD41.70019592
33TGFBR11.68023132
34GRK11.68023103
35BRSK21.65321471
36MUSK1.57282418
37MAPKAPK51.56631957
38NUAK11.53948044
39MAP3K61.48617570
40PHKG21.40532510
41PHKG11.40532510
42MAP2K61.38853564
43PRKG21.38083847
44CDK191.34242866
45WEE11.33713759
46GRK71.28652435
47TRPM71.27094555
48CLK11.26864938
49SCYL21.26006208
50MKNK11.25126166
51LRRK21.25003264
52DYRK31.21976373
53MARK31.21664043
54PIK3CG1.19333341
55HIPK21.16567164
56SRPK11.16381905
57MAP3K31.13911809
58TBK11.09831658
59TAOK11.05162871
60TTK1.05136051
61WNK11.04301667
62PBK1.01183216
63TNK20.96555188
64CSNK1G10.96337485
65STK160.94740756
66MAP4K10.94017168
67TXK0.91805537
68CDK30.87414000
69CDK90.86229720
70CSNK1G30.85242700
71MAPK110.85220294
72ILK0.84518987
73EIF2AK20.84412935
74MAP3K140.84053538
75MAP4K20.83797195
76MAP3K70.83052898
77ADRBK10.82095891
78PLK10.80397299
79MAPK120.80229886
80AURKB0.79597415
81CAMK40.78486796
82PAK40.77842206
83CSNK1A1L0.76732118
84VRK10.76401333
85MAP3K10.76165689
86CHEK20.75786467
87IKBKB0.75676243
88TAOK20.70692126
89MAP3K120.70451389
90BRAF0.70269767
91MAPK40.70101298
92MKNK20.69476997
93EPHB20.69037377
94CDK40.66932740
95TNIK0.63953693
96ZAP700.63921239
97JAK30.63325207
98TIE10.63185616
99NLK0.62145186
100MAP3K110.60842820
101PIM10.59914553
102ITK0.58786402
103MST40.58148457
104BLK0.57803276
105NEK60.57499850
106CDC70.57269302
107PRKD20.57253168
108PAK20.55495432
109MAPK70.55096178
110PRKCQ0.54824148
111LIMK10.53663396
112OXSR10.53258398
113RPS6KA50.53200769
114AURKA0.51859428
115LATS10.51458583
116MST1R0.51328903
117TTN0.51190156
118NME10.51031992
119LATS20.49375420
120BUB10.47260283
121FES0.47257761
122SYK0.46514501
123BRSK10.45359517
124TESK20.43941362
125NEK20.43817334
126MAPKAPK20.43312152
127MARK20.43153175
128RPS6KL10.43103334
129RPS6KC10.43103334
130RPS6KA60.42779738
131PAK10.42585145
132TESK10.41602468
133RPS6KA40.40225612
134DAPK10.38316018
135ZAK0.37992236
136ATR0.37426953
137NEK90.36661705
138RAF10.36234222
139CAMK2G0.35746734
140AKT20.35498089
141MAP2K40.35275371
142MYLK0.34448488
143CCNB10.34325665
144EIF2AK30.32996585
145EPHB10.30968181
146ABL20.30640876
147MAP2K20.29785767
148MAPK150.28518107
149LCK0.27923854
150CSNK1G20.27911521
151MAP3K80.27748875
152MAP3K50.27526000
153CDK20.26750615
154EPHA30.26315133

Predicted pathways (KEGG)

RankGene SetZ-score
1Ribosome_Homo sapiens_hsa030106.35434055
2DNA replication_Homo sapiens_hsa030303.52407633
3Cyanoamino acid metabolism_Homo sapiens_hsa004603.19285416
4Base excision repair_Homo sapiens_hsa034102.43573652
5Mismatch repair_Homo sapiens_hsa034302.42024328
62-Oxocarboxylic acid metabolism_Homo sapiens_hsa012102.38988065
7Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030082.34044215
8Homologous recombination_Homo sapiens_hsa034402.25809827
9Caffeine metabolism_Homo sapiens_hsa002322.11265336
10RNA polymerase_Homo sapiens_hsa030201.96574563
11Cell cycle_Homo sapiens_hsa041101.96375054
12Arachidonic acid metabolism_Homo sapiens_hsa005901.96343280
13Thyroid cancer_Homo sapiens_hsa052161.92743794
14Synthesis and degradation of ketone bodies_Homo sapiens_hsa000721.86988675
15Spliceosome_Homo sapiens_hsa030401.80666235
16Pyrimidine metabolism_Homo sapiens_hsa002401.74977518
17Fanconi anemia pathway_Homo sapiens_hsa034601.73718591
18Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007601.69956768
19Propanoate metabolism_Homo sapiens_hsa006401.67683429
20Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006031.66242143
21RNA degradation_Homo sapiens_hsa030181.66128708
22Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006301.66074771
23Valine, leucine and isoleucine degradation_Homo sapiens_hsa002801.63247923
24Transcriptional misregulation in cancer_Homo sapiens_hsa052021.58047567
25p53 signaling pathway_Homo sapiens_hsa041151.51415632
26Citrate cycle (TCA cycle)_Homo sapiens_hsa000201.50267761
27Nucleotide excision repair_Homo sapiens_hsa034201.48473947
28RNA transport_Homo sapiens_hsa030131.46765687
29Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006011.45650850
30Cytosolic DNA-sensing pathway_Homo sapiens_hsa046231.43046378
31Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001301.42137229
32Asthma_Homo sapiens_hsa053101.33360997
33Phenylalanine metabolism_Homo sapiens_hsa003601.32521604
34RIG-I-like receptor signaling pathway_Homo sapiens_hsa046221.30124688
35Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005331.29581875
36Non-homologous end-joining_Homo sapiens_hsa034501.22338428
37Cysteine and methionine metabolism_Homo sapiens_hsa002701.20277330
38Folate biosynthesis_Homo sapiens_hsa007901.19896415
39Basal transcription factors_Homo sapiens_hsa030221.19308545
40Acute myeloid leukemia_Homo sapiens_hsa052211.06682939
41Other glycan degradation_Homo sapiens_hsa005111.06223563
42Olfactory transduction_Homo sapiens_hsa047401.04551292
43Herpes simplex infection_Homo sapiens_hsa051681.03832144
44Sulfur relay system_Homo sapiens_hsa041221.03752146
45Regulation of autophagy_Homo sapiens_hsa041401.00170168
46Galactose metabolism_Homo sapiens_hsa000520.98313857
47Fc epsilon RI signaling pathway_Homo sapiens_hsa046640.98130233
48Carbon metabolism_Homo sapiens_hsa012000.97768149
49Sulfur metabolism_Homo sapiens_hsa009200.97516662
50Vitamin B6 metabolism_Homo sapiens_hsa007500.96974990
51Steroid hormone biosynthesis_Homo sapiens_hsa001400.96410122
52Chemical carcinogenesis_Homo sapiens_hsa052040.95391088
53Jak-STAT signaling pathway_Homo sapiens_hsa046300.95237258
54alpha-Linolenic acid metabolism_Homo sapiens_hsa005920.95204079
55Bladder cancer_Homo sapiens_hsa052190.92380768
56Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa005200.92025018
57Linoleic acid metabolism_Homo sapiens_hsa005910.90330609
58Hematopoietic cell lineage_Homo sapiens_hsa046400.89872463
59Tyrosine metabolism_Homo sapiens_hsa003500.88932145
60Inflammatory bowel disease (IBD)_Homo sapiens_hsa053210.87455854
61Primary immunodeficiency_Homo sapiens_hsa053400.86417036
62Sphingolipid metabolism_Homo sapiens_hsa006000.84302429
63Basal cell carcinoma_Homo sapiens_hsa052170.83878176
64Circadian rhythm_Homo sapiens_hsa047100.82602232
65Leishmaniasis_Homo sapiens_hsa051400.82310843
66Fructose and mannose metabolism_Homo sapiens_hsa000510.81772279
67Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate_Homo sapiens_hsa005320.80950206
68Peroxisome_Homo sapiens_hsa041460.79822709
69Pentose and glucuronate interconversions_Homo sapiens_hsa000400.79596921
70Butanoate metabolism_Homo sapiens_hsa006500.77555867
71Pathways in cancer_Homo sapiens_hsa052000.74570054
72Shigellosis_Homo sapiens_hsa051310.73107345
73Amyotrophic lateral sclerosis (ALS)_Homo sapiens_hsa050140.72215178
74Hypertrophic cardiomyopathy (HCM)_Homo sapiens_hsa054100.70497569
75Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004000.70061017
76Drug metabolism - cytochrome P450_Homo sapiens_hsa009820.69822170
77MicroRNAs in cancer_Homo sapiens_hsa052060.69655646
78Platelet activation_Homo sapiens_hsa046110.69056993
79HTLV-I infection_Homo sapiens_hsa051660.67108831
80Fatty acid elongation_Homo sapiens_hsa000620.66953927
81Non-small cell lung cancer_Homo sapiens_hsa052230.66366127
82Calcium signaling pathway_Homo sapiens_hsa040200.66277669
83Cardiac muscle contraction_Homo sapiens_hsa042600.65201285
84Purine metabolism_Homo sapiens_hsa002300.64387282
85Small cell lung cancer_Homo sapiens_hsa052220.63551150
86Pentose phosphate pathway_Homo sapiens_hsa000300.63477614
87Proteasome_Homo sapiens_hsa030500.61722954
88Cytokine-cytokine receptor interaction_Homo sapiens_hsa040600.60205549
89Chronic myeloid leukemia_Homo sapiens_hsa052200.57821170
90Notch signaling pathway_Homo sapiens_hsa043300.57805462
91Pathogenic Escherichia coli infection_Homo sapiens_hsa051300.57115289
92Dorso-ventral axis formation_Homo sapiens_hsa043200.56852269
93Glutathione metabolism_Homo sapiens_hsa004800.56658865
94Pancreatic cancer_Homo sapiens_hsa052120.55536843
95Intestinal immune network for IgA production_Homo sapiens_hsa046720.53887614
96Drug metabolism - other enzymes_Homo sapiens_hsa009830.53460614
97Hedgehog signaling pathway_Homo sapiens_hsa043400.53420449
98Glycerophospholipid metabolism_Homo sapiens_hsa005640.53215381
99Huntingtons disease_Homo sapiens_hsa050160.52705712
100B cell receptor signaling pathway_Homo sapiens_hsa046620.52106287
101Ovarian steroidogenesis_Homo sapiens_hsa049130.52055266
102Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa045500.51561883
103Oxidative phosphorylation_Homo sapiens_hsa001900.50638832
104Renin secretion_Homo sapiens_hsa049240.50369558
105Arginine and proline metabolism_Homo sapiens_hsa003300.49910972
106Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa009700.49736287
107Metabolic pathways_Homo sapiens_hsa011000.49577848
108Fc gamma R-mediated phagocytosis_Homo sapiens_hsa046660.49171622
109Vascular smooth muscle contraction_Homo sapiens_hsa042700.49048155
110SNARE interactions in vesicular transport_Homo sapiens_hsa041300.46886553
111cGMP-PKG signaling pathway_Homo sapiens_hsa040220.45864506
112One carbon pool by folate_Homo sapiens_hsa006700.45452680
113Protein export_Homo sapiens_hsa030600.44607062
114Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009800.44451181
115Histidine metabolism_Homo sapiens_hsa003400.43775222
116N-Glycan biosynthesis_Homo sapiens_hsa005100.43544274
117Alzheimers disease_Homo sapiens_hsa050100.42842098
118Taurine and hypotaurine metabolism_Homo sapiens_hsa004300.42438731
119Apoptosis_Homo sapiens_hsa042100.42143202
120Oxytocin signaling pathway_Homo sapiens_hsa049210.41216172
121PI3K-Akt signaling pathway_Homo sapiens_hsa041510.41031838
122Pantothenate and CoA biosynthesis_Homo sapiens_hsa007700.40392749
123Vitamin digestion and absorption_Homo sapiens_hsa049770.39562813
124Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005630.38108214
125Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049320.38098358
126Dilated cardiomyopathy_Homo sapiens_hsa054140.37996685
127mRNA surveillance pathway_Homo sapiens_hsa030150.37982161
128Allograft rejection_Homo sapiens_hsa053300.37970661
129Fatty acid degradation_Homo sapiens_hsa000710.37803736
130Arginine biosynthesis_Homo sapiens_hsa002200.36656122
131Toxoplasmosis_Homo sapiens_hsa051450.36404128
132NOD-like receptor signaling pathway_Homo sapiens_hsa046210.36041686
133Epstein-Barr virus infection_Homo sapiens_hsa051690.35086057
134Viral myocarditis_Homo sapiens_hsa054160.34766228
135Viral carcinogenesis_Homo sapiens_hsa052030.34559166
136Glucagon signaling pathway_Homo sapiens_hsa049220.34431333
137Glycine, serine and threonine metabolism_Homo sapiens_hsa002600.33613848
138Glycosaminoglycan degradation_Homo sapiens_hsa005310.32751785
139Protein digestion and absorption_Homo sapiens_hsa049740.32713453
140Sphingolipid signaling pathway_Homo sapiens_hsa040710.32127506
141Melanoma_Homo sapiens_hsa052180.31850509
142Leukocyte transendothelial migration_Homo sapiens_hsa046700.31525919
143Renin-angiotensin system_Homo sapiens_hsa046140.31192161
144Ether lipid metabolism_Homo sapiens_hsa005650.29719492
145Antigen processing and presentation_Homo sapiens_hsa046120.29570804
146Measles_Homo sapiens_hsa051620.29370818
147Parkinsons disease_Homo sapiens_hsa050120.29155844
148NF-kappa B signaling pathway_Homo sapiens_hsa040640.29070720
149Influenza A_Homo sapiens_hsa051640.28244873
150Malaria_Homo sapiens_hsa051440.27817325

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