HOXA9

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: In vertebrates, the genes encoding the class of transcription factors called homeobox genes are found in clusters named A, B, C, and D on four separate chromosomes. Expression of these proteins is spatially and temporally regulated during embryonic development. This gene is part of the A cluster on chromosome 7 and encodes a DNA-binding transcription factor which may regulate gene expression, morphogenesis, and differentiation. This gene is highly similar to the abdominal-B (Abd-B) gene of Drosophila. A specific translocation event which causes a fusion between this gene and the NUP98 gene has been associated with myeloid leukemogenesis. Read-through transcription exists between this gene and the upstream homeobox A10 (HOXA10) gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1ribosomal small subunit assembly (GO:0000028)7.31928445
2antigen processing and presentation of endogenous peptide antigen via MHC class I (GO:0019885)7.22056270
3antigen processing and presentation of endogenous peptide antigen (GO:0002483)7.22056270
4antigen processing and presentation via MHC class Ib (GO:0002475)6.72789677
5definitive hemopoiesis (GO:0060216)6.42420243
6viral transcription (GO:0019083)6.02603363
7antigen processing and presentation of endogenous antigen (GO:0019883)5.75212292
8translational termination (GO:0006415)5.69424044
9thyroid gland development (GO:0030878)5.28012554
10ribosomal small subunit biogenesis (GO:0042274)5.18967715
11megakaryocyte development (GO:0035855)5.17547456
12SRP-dependent cotranslational protein targeting to membrane (GO:0006614)5.08473799
13translational elongation (GO:0006414)5.04400961
14deoxyribonucleoside monophosphate metabolic process (GO:0009162)4.99304520
15negative regulation of B cell apoptotic process (GO:0002903)4.97150958
16cotranslational protein targeting to membrane (GO:0006613)4.95327338
17protein targeting to ER (GO:0045047)4.95175945
18establishment of protein localization to endoplasmic reticulum (GO:0072599)4.71015871
19antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-independent (G4.70946958
20protein localization to endoplasmic reticulum (GO:0070972)4.65491194
21lymph vessel development (GO:0001945)4.63746757
22regulation of antigen processing and presentation of peptide antigen (GO:0002583)4.56318037
23viral life cycle (GO:0019058)4.47931034
24poly(A)+ mRNA export from nucleus (GO:0016973)4.45500227
25nuclear-transcribed mRNA catabolic process, nonsense-mediated decay (GO:0000184)4.41665174
26cellular protein complex disassembly (GO:0043624)4.28786036
27pentose-phosphate shunt (GO:0006098)4.18498370
28DNA deamination (GO:0045006)4.08717741
29negative regulation of erythrocyte differentiation (GO:0045647)4.02199945
30translational initiation (GO:0006413)3.98877254
31regulation of B cell apoptotic process (GO:0002902)3.95496062
32maturation of SSU-rRNA (GO:0030490)3.94780170
33protein complex disassembly (GO:0043241)3.93585488
34DNA unwinding involved in DNA replication (GO:0006268)3.87205237
35dosage compensation (GO:0007549)3.85391938
36lymphoid progenitor cell differentiation (GO:0002320)3.85203132
37pyrimidine deoxyribonucleotide catabolic process (GO:0009223)3.83149689
38proline biosynthetic process (GO:0006561)3.76569127
39purine nucleotide salvage (GO:0032261)3.70993651
40negative regulation of phagocytosis (GO:0050765)3.64498732
41NADPH regeneration (GO:0006740)3.62558929
42L-fucose catabolic process (GO:0042355)3.60841383
43fucose catabolic process (GO:0019317)3.60841383
44L-fucose metabolic process (GO:0042354)3.60841383
45thrombin receptor signaling pathway (GO:0070493)3.60791188
46macromolecular complex disassembly (GO:0032984)3.60198503
47regulation of mammary gland epithelial cell proliferation (GO:0033599)3.59836012
48rRNA catabolic process (GO:0016075)3.55150621
49polyketide metabolic process (GO:0030638)3.54708114
50doxorubicin metabolic process (GO:0044598)3.54708114
51daunorubicin metabolic process (GO:0044597)3.54708114
52negative regulation of mRNA processing (GO:0050686)3.53236724
53positive regulation of B cell differentiation (GO:0045579)3.49069869
54platelet dense granule organization (GO:0060155)3.48668283
55response to interferon-beta (GO:0035456)3.47031339
56telomere maintenance via semi-conservative replication (GO:0032201)3.45939795
57positive regulation of receptor biosynthetic process (GO:0010870)3.44448362
58UV protection (GO:0009650)3.43272849
59regulation of single stranded viral RNA replication via double stranded DNA intermediate (GO:00450913.41646117
60cranial nerve morphogenesis (GO:0021602)3.34604742
61viral mRNA export from host cell nucleus (GO:0046784)3.32500455
62DNA strand elongation involved in DNA replication (GO:0006271)3.32266377
63protein targeting to membrane (GO:0006612)3.29986741
64embryonic heart tube development (GO:0035050)3.29694358
65nuclear-transcribed mRNA catabolic process (GO:0000956)3.28515397
66mature B cell differentiation involved in immune response (GO:0002313)3.27294121
67DNA strand elongation (GO:0022616)3.25398464
68embryonic skeletal joint morphogenesis (GO:0060272)3.23678090
69uterus development (GO:0060065)3.18475724
70aminoglycoside antibiotic metabolic process (GO:0030647)3.17573285
71alternative mRNA splicing, via spliceosome (GO:0000380)3.16890805
72pyrimidine nucleotide catabolic process (GO:0006244)3.16401106
73deoxyribose phosphate catabolic process (GO:0046386)3.15422736
74embryonic skeletal system morphogenesis (GO:0048704)3.14888794
75IMP metabolic process (GO:0046040)3.13825713
76mRNA catabolic process (GO:0006402)3.13115201
77peripheral nervous system neuron development (GO:0048935)3.11792820
78endothelium development (GO:0003158)3.10031221
79ribosome biogenesis (GO:0042254)3.07858500
80protein localization to kinetochore (GO:0034501)3.04705668
81nucleotide salvage (GO:0043173)3.04515683
82RNA catabolic process (GO:0006401)3.03288603
83Peyers patch development (GO:0048541)3.02923105
84mucosal-associated lymphoid tissue development (GO:0048537)3.02923105
85ribosomal large subunit biogenesis (GO:0042273)3.02880227
86deoxyribonucleotide catabolic process (GO:0009264)3.00058004
87DNA topological change (GO:0006265)2.99746200
88cellular response to exogenous dsRNA (GO:0071360)2.99399908
89purine-containing compound salvage (GO:0043101)2.99337251
90negative regulation of RNA splicing (GO:0033119)2.98120359
91macrophage differentiation (GO:0030225)2.97606419
92response to protozoan (GO:0001562)2.96907327
93regulation of B cell differentiation (GO:0045577)2.96591248
94positive regulation of protein deacetylation (GO:0090312)2.96360262
95secretory granule organization (GO:0033363)2.95867126
96mast cell activation (GO:0045576)2.95404844
973-UTR-mediated mRNA stabilization (GO:0070935)2.94541154
98defense response to protozoan (GO:0042832)2.92255739
99negative regulation of vascular endothelial growth factor receptor signaling pathway (GO:0030948)2.92019129
100rRNA processing (GO:0006364)2.91038954
101rRNA metabolic process (GO:0016072)2.90458315
102negative regulation of mRNA metabolic process (GO:1903312)2.88881643
103ribonucleoprotein complex biogenesis (GO:0022613)2.88684876
104purine deoxyribonucleotide catabolic process (GO:0009155)2.87857212
105cyclooxygenase pathway (GO:0019371)2.87334888
106grooming behavior (GO:0007625)2.85883263
107respiratory tube development (GO:0030323)2.84463837
108response to interferon-alpha (GO:0035455)2.83945363
109regulation of apoptotic process involved in morphogenesis (GO:1902337)2.83871903
110telomere maintenance via recombination (GO:0000722)2.83532941
111endosome to pigment granule transport (GO:0043485)2.83474369
112endosome to melanosome transport (GO:0035646)2.83474369
113necroptotic process (GO:0070266)2.83413569
114lipoxygenase pathway (GO:0019372)2.81565915
115regulation of histone phosphorylation (GO:0033127)2.81546559
116cellular component biogenesis (GO:0044085)2.80592987
117regulation of T-helper 1 cell differentiation (GO:0045625)2.80128306
118execution phase of apoptosis (GO:0097194)2.79828386
119DNA replication initiation (GO:0006270)2.79238529
120aggressive behavior (GO:0002118)2.78850329
121cellular hyperosmotic response (GO:0071474)2.75843848
122negative regulation of cell cycle G2/M phase transition (GO:1902750)2.74785933
123regulation of mitochondrial translation (GO:0070129)2.74403312
124Arp2/3 complex-mediated actin nucleation (GO:0034314)2.73112285
125ribosome assembly (GO:0042255)2.72706919
126glucose catabolic process (GO:0006007)2.72118188
127positive regulation of megakaryocyte differentiation (GO:0045654)2.69921658
128translation (GO:0006412)2.69333483
129positive regulation of histone H3-K4 methylation (GO:0051571)2.66893122
130mitotic recombination (GO:0006312)2.66348023
131purine nucleobase metabolic process (GO:0006144)2.65247886
132pseudouridine synthesis (GO:0001522)2.65029307
133pyrimidine deoxyribonucleotide metabolic process (GO:0009219)2.64142799
134formation of translation preinitiation complex (GO:0001731)2.64027159
135negative regulation of CD4-positive, alpha-beta T cell differentiation (GO:0043371)2.63333462
136negative regulation of T-helper cell differentiation (GO:0045623)2.63333462
137negative regulation of mRNA splicing, via spliceosome (GO:0048025)2.63036775
138IMP biosynthetic process (GO:0006188)2.62745201
139mitochondrial calcium ion transport (GO:0006851)2.62213902
140proximal/distal pattern formation (GO:0009954)2.61800072
141oxidative phosphorylation (GO:0006119)2.60863071
142hexose catabolic process (GO:0019320)2.59484841
143positive regulation of T cell mediated cytotoxicity (GO:0001916)2.58195630
144purine deoxyribonucleoside triphosphate metabolic process (GO:0009215)2.57112196
145deoxyribonucleoside triphosphate metabolic process (GO:0009200)2.56775550
146angiogenesis involved in wound healing (GO:0060055)2.56534938
147regulation of erythrocyte differentiation (GO:0045646)2.56298984
148rRNA transcription (GO:0009303)2.55678872
149immunoglobulin mediated immune response (GO:0016064)2.53725638
150maternal placenta development (GO:0001893)2.53529822
151mast cell degranulation (GO:0043303)2.52976530
152mast cell activation involved in immune response (GO:0002279)2.52976530
153regulation of T cell mediated cytotoxicity (GO:0001914)2.51994172
154T cell apoptotic process (GO:0070231)2.51900543
155termination of RNA polymerase II transcription (GO:0006369)2.51020827
156myeloid cell development (GO:0061515)2.50688529
157morphogenesis of an epithelial fold (GO:0060571)2.50625344
158intra-S DNA damage checkpoint (GO:0031573)2.50519461
1592-deoxyribonucleotide metabolic process (GO:0009394)2.48380784
160L-methionine biosynthetic process from methylthioadenosine (GO:0019509)2.48303263
161pyrimidine nucleoside triphosphate metabolic process (GO:0009147)2.47578510
162regulation of necroptotic process (GO:0060544)2.46688878
163skeletal system morphogenesis (GO:0048705)2.44575181
164fucosylation (GO:0036065)2.42855729
165type I interferon signaling pathway (GO:0060337)2.42758568
166cellular response to type I interferon (GO:0071357)2.42758568

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1E2F7_22180533_ChIP-Seq_HELA_Human6.24629319
2EKLF_21900194_ChIP-Seq_ERYTHROCYTE_Mouse3.50468991
3SCL_19346495_ChIP-Seq_HPC-7_Human3.37445032
4* CHD7_19251738_ChIP-ChIP_MESCs_Mouse3.35560771
5BP1_19119308_ChIP-ChIP_Hs578T_Human3.13470112
6ELF1_17652178_ChIP-ChIP_JURKAT_Human3.02987021
7MECOM_23826213_ChIP-Seq_KASUMI_Mouse2.97269700
8* VDR_21846776_ChIP-Seq_THP-1_Human2.95507230
9MYC_18555785_ChIP-Seq_MESCs_Mouse2.85935323
10MYC_22102868_ChIP-Seq_BL_Human2.84372363
11RUNX1_20887958_ChIP-Seq_HPC-7_Mouse2.79545166
12SPI1_22790984_ChIP-Seq_ERYTHROLEUKEMIA_Mouse2.76192979
13MYB_21317192_ChIP-Seq_ERMYB_Mouse2.68142773
14IRF8_22096565_ChIP-ChIP_GC-B_Human2.51374210
15IRF8_22096565_ChIP-ChIP_GC-B_Mouse2.45073511
16NOTCH1_17114293_ChIP-ChIP_T-ALL_Human2.44386559
17TAL1_20887958_ChIP-Seq_HPC-7_Mouse2.43174573
18HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse2.42231806
19SOX9_22984422_ChIP-ChIP_TESTIS_Rat2.36932027
20FLI1_20887958_ChIP-Seq_HPC-7_Mouse2.35650900
21E2F4_17652178_ChIP-ChIP_JURKAT_Human2.21377921
22SPI1_23547873_ChIP-Seq_NB4_Human2.16247362
23EGR1_19374776_ChIP-ChIP_THP-1_Human2.14824924
24SPI1_22096565_ChIP-ChIP_GC-B_Mouse2.13493209
25MYBL1_21750041_ChIP-ChIP_SPERMATOCYTES_Mouse2.13313931
26HCFC1_20581084_ChIP-Seq_MESCs_Mouse2.11425565
27MYC_18358816_ChIP-ChIP_MESCs_Mouse2.04797062
28FOXM1_23109430_ChIP-Seq_U2OS_Human2.02793596
29FOXM1_25889361_ChIP-Seq_OE33_AND_U2OS_Human2.01992459
30BCL3_23251550_ChIP-Seq_MUSCLE_Mouse2.00623423
31ASXL1_24218140_ChIP-Seq_BMDM_Mouse1.97871741
32ERG_20887958_ChIP-Seq_HPC-7_Mouse1.93868290
33* VDR_24763502_ChIP-Seq_THP-1_Human1.87645609
34MYC_19079543_ChIP-ChIP_MESCs_Mouse1.85259925
35ZNF263_19887448_ChIP-Seq_K562_Human1.84961424
36SFPI1_20887958_ChIP-Seq_HPC-7_Mouse1.84299803
37HOXB4_20404135_ChIP-ChIP_EML_Mouse1.83217790
38IRF1_21803131_ChIP-Seq_MONOCYTES_Human1.79117445
39* XRN2_22483619_ChIP-Seq_HELA_Human1.78981305
40RUNX1_22412390_ChIP-Seq_EML_Mouse1.77993978
41MYC_19030024_ChIP-ChIP_MESCs_Mouse1.77210443
42KDM5A_27292631_Chip-Seq_BREAST_Human1.76655110
43CIITA_25753668_ChIP-Seq_RAJI_Human1.75685251
44GATA1_22025678_ChIP-Seq_K562_Human1.74527352
45TCF7_22412390_ChIP-Seq_EML_Mouse1.71128074
46* BRD4_27068464_Chip-Seq_AML-cells_Mouse1.67264099
47EST1_17652178_ChIP-ChIP_JURKAT_Human1.66915509
48LYL1_20887958_ChIP-Seq_HPC-7_Mouse1.66798997
49DACH1_20351289_ChIP-Seq_MDA-MB-231_Human1.66409652
50NR1H3_23393188_ChIP-Seq_ATHEROSCLEROTIC-FOAM_Human1.65543616
51MAF_26560356_Chip-Seq_TH1_Human1.65116102
52ESR1_15608294_ChIP-ChIP_MCF-7_Human1.63162386
53LMO2_20887958_ChIP-Seq_HPC-7_Mouse1.58272120
54GFI1B_20887958_ChIP-Seq_HPC-7_Mouse1.57842706
55FOXP3_21729870_ChIP-Seq_TREG_Human1.57037502
56VDR_23849224_ChIP-Seq_CD4+_Human1.56796611
57ETS1_20019798_ChIP-Seq_JURKAT_Human1.55457567
58MEIS1_20887958_ChIP-Seq_HPC-7_Mouse1.53130452
59UTX_26944678_Chip-Seq_JUKART_Human1.52962667
60GATA1_22383799_ChIP-Seq_G1ME_Mouse1.52892257
61TP63_19390658_ChIP-ChIP_HaCaT_Human1.51530794
62MYB_26560356_Chip-Seq_TH2_Human1.49692562
63MYB_26560356_Chip-Seq_TH1_Human1.47791613
64NCOR_22465074_ChIP-Seq_MACROPHAGES_Mouse1.42426663
65ELF1_20517297_ChIP-Seq_JURKAT_Human1.41041495
66STAT4_19710469_ChIP-ChIP_TH1__Mouse1.38840164
67PPARG_23326641_ChIP-Seq_C3H10T1-2_Mouse1.38709874
68JARID1A_20064375_ChIP-Seq_MESCs_Mouse1.38612975
69GABP_17652178_ChIP-ChIP_JURKAT_Human1.38354592
70YY1_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse1.35883185
71SMRT_22465074_ChIP-Seq_MACROPHAGES_Mouse1.35793408
72PRDM16_22522345_ChIP-ChIP_PALATE_MESENCHYMAL_Mouse1.35007945
73* TET1_21451524_ChIP-Seq_MESCs_Mouse1.31705090
74NOTCH1_21737748_ChIP-Seq_TLL_Human1.30201059
75TBP_23326641_ChIP-Seq_C3H10T1-2_Mouse1.27511264
76CNOT3_19339689_ChIP-ChIP_MESCs_Mouse1.27390703
77E2F1_18555785_ChIP-Seq_MESCs_Mouse1.26686330
78TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat1.25304666
79STAT6_20620947_ChIP-Seq_CD4_POS_T_Human1.23777013
80* ELK3_25401928_ChIP-Seq_HUVEC_Human1.22171054
81IRF8_21731497_ChIP-ChIP_J774_Mouse1.20331404
82ZFX_18555785_ChIP-Seq_MESCs_Mouse1.20281811
83MYCN_21190229_ChIP-Seq_SHEP-21N_Human1.18815554
84E2A_27217539_Chip-Seq_RAMOS-Cell_line_Human1.18675953
85NELFA_20434984_ChIP-Seq_ESCs_Mouse1.18455973
86CHD1_19587682_ChIP-ChIP_MESCs_Mouse1.18371518
87* TTF2_22483619_ChIP-Seq_HELA_Human1.18272277
88E2F4_21247883_ChIP-Seq_LYMPHOBLASTOID_Human1.18082861
89FOXO3_22982991_ChIP-Seq_MACROPHAGES_Mouse1.18068720
90MYC_18940864_ChIP-ChIP_HL60_Human1.16110920
91GATA2_20887958_ChIP-Seq_HPC-7_Mouse1.15912225
92KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human1.15468496
93GATA2_22383799_ChIP-Seq_G1ME_Mouse1.14665458
94GABP_19822575_ChIP-Seq_HepG2_Human1.14038388
95* MYBL2_22936984_ChIP-ChIP_MESCs_Mouse1.13837019
96E2F1_21310950_ChIP-Seq_MCF-7_Human1.13366810
97CREB1_15753290_ChIP-ChIP_HEK293T_Human1.12481525
98* KLF4_19030024_ChIP-ChIP_MESCs_Mouse1.11520679
99POU5F1_18555785_ChIP-Seq_MESCs_Mouse1.10824546
100KDM2B_26808549_Chip-Seq_SIL-ALL_Human1.10692906
101PPARG_19300518_ChIP-PET_3T3-L1_Mouse1.08146474
102CTCF_26484167_Chip-Seq_Bcells_Mouse1.08112491
103TAL1_20566737_ChIP-Seq_PRIMARY_FETAL_LIVER_ERYTHROID_Mouse1.07800776
104HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human1.07198439
105ZNF652_21678463_ChIP-ChIP_ZR75-1_Human1.07167452
106MAF_26560356_Chip-Seq_TH2_Human1.06584592
107YY1_21170310_ChIP-Seq_MESCs_Mouse1.05157837
108ZFP42_18358816_ChIP-ChIP_MESCs_Mouse1.04976524
109CIITA_18437201_ChIP-ChIP_Raji_B_and_iDC_Human1.04447940
110SPI1_23127762_ChIP-Seq_K562_Human1.04085715
111CEBPB_24764292_ChIP-Seq_MC3T3_Mouse1.03169648
112* BCL6_27268052_Chip-Seq_Bcells_Human1.02934482
113IRF8_27001747_Chip-Seq_BMDM_Mouse1.02899684
114CREB1_23762244_ChIP-Seq_HIPPOCAMPUS_Rat1.02328713
115MYCN_18555785_ChIP-Seq_MESCs_Mouse1.01706080
116THAP11_20581084_ChIP-Seq_MESCs_Mouse1.00410677
117SRF_21415370_ChIP-Seq_HL-1_Mouse0.99908003
118CTCF_18555785_ChIP-Seq_MESCs_Mouse0.99429296
119* PHC1_16625203_ChIP-ChIP_MESCs_Mouse0.97598141
120P68_20966046_ChIP-Seq_HELA_Human0.96973006
121AR_21909140_ChIP-Seq_LNCAP_Human0.96423738
122FOXO1_25302145_ChIP-Seq_T-LYMPHOCYTE_Mouse0.96422238
123PKCTHETA_26484144_Chip-Seq_BREAST_Human0.95914769
124PDX1_19855005_ChIP-ChIP_MIN6_Mouse0.95888820
125DCP1A_22483619_ChIP-Seq_HELA_Human0.95217594
126CUX1_19635798_ChIP-ChIP_MULTIPLE_HUMAN_CANCER_TYPES_Human0.93789510
127TFEB_21752829_ChIP-Seq_HELA_Human0.93784879
128KDM2B_26808549_Chip-Seq_HPB-ALL_Human0.93720759
129* ELK1_19687146_ChIP-ChIP_HELA_Human0.92287182
130STAT3_1855785_ChIP-Seq_MESCs_Mouse0.91198205
131CCND1_20090754_ChIP-ChIP_RETINA_Mouse0.90693009

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0002396_abnormal_hematopoietic_system5.18438954
2MP0001835_abnormal_antigen_presentation3.29571721
3MP0002160_abnormal_reproductive_system2.93374213
4MP0002009_preneoplasia2.86296854
5MP0005174_abnormal_tail_pigmentation2.85282040
6* MP0004808_abnormal_hematopoietic_stem2.83421027
7MP0005075_abnormal_melanosome_morpholog2.76905339
8MP0000685_abnormal_immune_system2.71613883
9MP0005397_hematopoietic_system_phenotyp2.64229462
10MP0001545_abnormal_hematopoietic_system2.64229462
11MP0000490_abnormal_crypts_of2.60187435
12MP0002249_abnormal_larynx_morphology2.58435034
13MP0005464_abnormal_platelet_physiology2.56248115
14MP0009785_altered_susceptibility_to2.51863129
15MP0003806_abnormal_nucleotide_metabolis2.38681953
16MP0000465_gastrointestinal_hemorrhage2.31017424
17MP0000516_abnormal_urinary_system2.29435450
18MP0005367_renal/urinary_system_phenotyp2.29435450
19MP0003693_abnormal_embryo_hatching2.25212044
20MP0009697_abnormal_copulation2.19293658
21MP0002166_altered_tumor_susceptibility2.13727802
22* MP0002398_abnormal_bone_marrow2.09295662
23MP0005025_abnormal_response_to2.06147293
24MP0005671_abnormal_response_to2.03823421
25MP0004264_abnormal_extraembryonic_tissu1.92868598
26MP0002877_abnormal_melanocyte_morpholog1.92564011
27MP0003436_decreased_susceptibility_to1.83593325
28* MP0002722_abnormal_immune_system1.82849513
29* MP0000689_abnormal_spleen_morphology1.81355537
30MP0008007_abnormal_cellular_replicative1.80318736
31MP0002420_abnormal_adaptive_immunity1.80287056
32MP0009278_abnormal_bone_marrow1.80220001
33MP0002095_abnormal_skin_pigmentation1.79612674
34MP0004782_abnormal_surfactant_physiolog1.79604884
35MP0002234_abnormal_pharynx_morphology1.78436507
36MP0001819_abnormal_immune_cell1.77622738
37MP0010094_abnormal_chromosome_stability1.75388468
38MP0004957_abnormal_blastocyst_morpholog1.75041023
39MP0008057_abnormal_DNA_replication1.74360968
40* MP0002429_abnormal_blood_cell1.73818459
41MP0000716_abnormal_immune_system1.72894700
42MP0003077_abnormal_cell_cycle1.70597946
43MP0001800_abnormal_humoral_immune1.70221376
44MP0002452_abnormal_antigen_presenting1.68889983
45MP0009379_abnormal_foot_pigmentation1.68067907
46MP0002723_abnormal_immune_serum1.67723010
47MP0000537_abnormal_urethra_morphology1.66912576
48MP0004185_abnormal_adipocyte_glucose1.66744818
49MP0001873_stomach_inflammation1.66327060
50MP0010155_abnormal_intestine_physiology1.65952880
51MP0002419_abnormal_innate_immunity1.65113107
52MP0002148_abnormal_hypersensitivity_rea1.60903854
53MP0003866_abnormal_defecation1.60366518
54MP0009333_abnormal_splenocyte_physiolog1.58165208
55MP0009250_abnormal_appendicular_skeleto1.53635202
56MP0001188_hyperpigmentation1.53509756
57MP0001986_abnormal_taste_sensitivity1.47931553
58MP0002006_tumorigenesis1.44576871
59MP0005000_abnormal_immune_tolerance1.44482615
60MP0003763_abnormal_thymus_physiology1.43232787
61MP0001853_heart_inflammation1.40537242
62MP0002822_catalepsy1.39451547
63MP0005646_abnormal_pituitary_gland1.38676321
64MP0003786_premature_aging1.38256855
65MP0000703_abnormal_thymus_morphology1.36753922
66MP0003300_gastrointestinal_ulcer1.35022556
67MP0000015_abnormal_ear_pigmentation1.34237174
68MP0000343_altered_response_to1.31631554
69MP0003172_abnormal_lysosome_physiology1.30980330
70MP0006292_abnormal_olfactory_placode1.26698679
71MP0003567_abnormal_fetal_cardiomyocyte1.25727613
72MP0002019_abnormal_tumor_incidence1.25703516
73MP0008961_abnormal_basal_metabolism1.22599715
74MP0005389_reproductive_system_phenotype1.22197558
75MP0005084_abnormal_gallbladder_morpholo1.19197078
76MP0009053_abnormal_anal_canal1.18056018
77MP0002405_respiratory_system_inflammati1.18029828
78MP0001845_abnormal_inflammatory_respons1.17893805
79MP0001664_abnormal_digestion1.17873252
80MP0003183_abnormal_peptide_metabolism1.17186449
81MP0006054_spinal_hemorrhage1.16680990
82MP0000313_abnormal_cell_death1.15762312
83MP0003943_abnormal_hepatobiliary_system1.15482445
84MP0002089_abnormal_postnatal_growth/wei1.13210041
85MP0001790_abnormal_immune_system1.12883678
86MP0005387_immune_system_phenotype1.12883678
87MP0005187_abnormal_penis_morphology1.12549661
88MP0003111_abnormal_nucleus_morphology1.09496371
89MP0000372_irregular_coat_pigmentation1.06769715
90MP0005670_abnormal_white_adipose1.06582443
91* MP0002114_abnormal_axial_skeleton1.05202558
92MP0008469_abnormal_protein_level1.04804055
93MP0002132_abnormal_respiratory_system1.04401890
94MP0001348_abnormal_lacrimal_gland1.04269126
95MP0010352_gastrointestinal_tract_polyps1.01965715
96MP0001346_abnormal_lacrimal_gland1.01560199
97MP0006036_abnormal_mitochondrial_physio1.01155151
98MP0008058_abnormal_DNA_repair0.97757823
99MP0004147_increased_porphyrin_level0.95602260
100MP0000678_abnormal_parathyroid_gland0.95135883
101MP0001270_distended_abdomen0.94937943
102MP0000477_abnormal_intestine_morphology0.94793740
103MP0005623_abnormal_meninges_morphology0.93375615
104MP0005666_abnormal_adipose_tissue0.91216208
105MP0005220_abnormal_exocrine_pancreas0.91062990
106MP0003724_increased_susceptibility_to0.88755358
107MP0001764_abnormal_homeostasis0.87030322
108MP0005508_abnormal_skeleton_morphology0.86084604
109MP0002876_abnormal_thyroid_physiology0.86053187
110MP0008932_abnormal_embryonic_tissue0.86049531
111MP0003315_abnormal_perineum_morphology0.85652123
112MP0000467_abnormal_esophagus_morphology0.85089030
113MP0000013_abnormal_adipose_tissue0.84700934
114MP0005058_abnormal_lysosome_morphology0.81044522
115MP0000003_abnormal_adipose_tissue0.80573810
116MP0010307_abnormal_tumor_latency0.80072517
117MP0005375_adipose_tissue_phenotype0.79408200
118MP0000858_altered_metastatic_potential0.78668630
119MP0000350_abnormal_cell_proliferation0.78345840
120MP0003385_abnormal_body_wall0.76736665
121MP0005409_darkened_coat_color0.76727820
122MP0000733_abnormal_muscle_development0.76385513
123MP0003718_maternal_effect0.76160186
124MP0003123_paternal_imprinting0.75813799
125MP0005501_abnormal_skin_physiology0.75621293
126MP0002932_abnormal_joint_morphology0.73866128
127MP0001879_abnormal_lymphatic_vessel0.73780287
128MP0000762_abnormal_tongue_morphology0.72493546
129MP0001663_abnormal_digestive_system0.71793503
130MP0002135_abnormal_kidney_morphology0.71675244
131MP0000759_abnormal_skeletal_muscle0.71672576
132MP0000598_abnormal_liver_morphology0.71495627
133MP0002928_abnormal_bile_duct0.71191785
134MP0003656_abnormal_erythrocyte_physiolo0.70640834
135MP0001661_extended_life_span0.69258845
136MP0004947_skin_inflammation0.68656286
137MP0000371_diluted_coat_color0.68397535
138MP0002080_prenatal_lethality0.68030056
139MP0009931_abnormal_skin_appearance0.67697431
140MP0002282_abnormal_trachea_morphology0.67106363
141MP0002075_abnormal_coat/hair_pigmentati0.66818202
142MP0003828_pulmonary_edema0.66534306
143MP0009765_abnormal_xenobiotic_induced0.66079309
144MP0003191_abnormal_cellular_cholesterol0.65964625
145MP0005390_skeleton_phenotype0.64425528
146MP0001730_embryonic_growth_arrest0.63312075
147MP0005076_abnormal_cell_differentiation0.61902104
148MP0000681_abnormal_thyroid_gland0.59860435
149MP0010368_abnormal_lymphatic_system0.59857904
150MP0002938_white_spotting0.58513365
151MP0005023_abnormal_wound_healing0.58154072

Predicted human phenotypes

RankGene SetZ-score
1Chronic otitis media (HP:0000389)6.10708370
2Eczematoid dermatitis (HP:0000976)6.02091101
3Thrombocytosis (HP:0001894)5.32667735
4Aplastic anemia (HP:0001915)5.25715750
5Myositis (HP:0100614)4.87208180
6Elevated erythrocyte sedimentation rate (HP:0003565)4.69298393
7Nasal polyposis (HP:0100582)4.58497855
8Abnormality of cells of the erythroid lineage (HP:0012130)4.55497436
9Long clavicles (HP:0000890)4.50243359
10Reticulocytopenia (HP:0001896)4.40474494
11Abnormality of the nasal mucosa (HP:0000433)4.13856205
12Abnormal number of erythroid precursors (HP:0012131)4.10468466
13IgM deficiency (HP:0002850)3.92252625
14Petechiae (HP:0000967)3.76564807
15Short middle phalanx of the 5th finger (HP:0004220)3.59968462
16Recurrent abscess formation (HP:0002722)3.46932397
17Agammaglobulinemia (HP:0004432)3.43874854
18Recurrent bacterial skin infections (HP:0005406)3.30884953
19Septate vagina (HP:0001153)3.28465195
20Poikiloderma (HP:0001029)3.25524290
21Microvesicular hepatic steatosis (HP:0001414)3.23538269
22Recurrent bronchitis (HP:0002837)3.17719898
23Abnormality of the columella (HP:0009929)3.14473730
24Prolonged bleeding time (HP:0003010)3.12428140
25Acute lymphatic leukemia (HP:0006721)3.05980245
26Increased muscle lipid content (HP:0009058)3.05151080
27Increased intramyocellular lipid droplets (HP:0012240)3.01786386
28Acute myeloid leukemia (HP:0004808)2.99920202
29Reduced antithrombin III activity (HP:0001976)2.99721688
30Short 5th finger (HP:0009237)2.86681459
31Absent rod-and cone-mediated responses on ERG (HP:0007688)2.85854575
32Autoimmune hemolytic anemia (HP:0001890)2.85132069
33Ureteral stenosis (HP:0000071)2.83777873
34Abnormality of T cell physiology (HP:0011840)2.83496841
35Epistaxis (HP:0000421)2.83321568
36Thickened calvaria (HP:0002684)2.80572714
37Abnormal activity of mitochondrial respiratory chain (HP:0011922)2.80247508
38Decreased activity of mitochondrial respiratory chain (HP:0008972)2.80247508
39Cutaneous melanoma (HP:0012056)2.78124857
40Radial bowing (HP:0002986)2.74187911
41Pallor (HP:0000980)2.74066663
42Granulocytopenia (HP:0001913)2.71240352
43Entropion (HP:0000621)2.66215314
44B lymphocytopenia (HP:0010976)2.63026995
45Abnormality of B cell number (HP:0010975)2.63026995
46Aplasia/Hypoplasia of the 5th finger (HP:0006262)2.60191366
47Growth hormone excess (HP:0000845)2.58330023
48Syringomyelia (HP:0003396)2.57818837
49Spinal cord lesions (HP:0100561)2.57818837
50Type I transferrin isoform profile (HP:0003642)2.56208900
51Broad distal phalanx of finger (HP:0009836)2.54493470
52Abnormal delayed hypersensitivity skin test (HP:0002963)2.47325858
53Aplasia/Hypoplasia of the 1st metacarpal (HP:0010026)2.47088517
54Short 1st metacarpal (HP:0010034)2.47088517
55Ureteral obstruction (HP:0006000)2.46790516
56Recurrent skin infections (HP:0001581)2.43969458
57Cellulitis (HP:0100658)2.41038186
58Meningitis (HP:0001287)2.39143452
59Severe combined immunodeficiency (HP:0004430)2.36658544
60Autoimmune thrombocytopenia (HP:0001973)2.32482995
61Myelodysplasia (HP:0002863)2.32069107
62Cerebral palsy (HP:0100021)2.30703630
63Interstitial pulmonary disease (HP:0006530)2.29589664
64Macrocytic anemia (HP:0001972)2.28572928
65Abnormal platelet function (HP:0011869)2.28026273
66Impaired platelet aggregation (HP:0003540)2.28026273
67Abnormality of macrophages (HP:0004311)2.27771174
68Abnormality of the 1st metacarpal (HP:0010009)2.27609834
69Single umbilical artery (HP:0001195)2.27171744
70Abnormality of the fetal cardiovascular system (HP:0010948)2.27171744
71Abnormal umbilical cord blood vessels (HP:0011403)2.27171744
72Ulnar deviation of the wrist (HP:0003049)2.27104062
73Abnormality of the middle phalanx of the 5th finger (HP:0004219)2.26202003
74Orchitis (HP:0100796)2.23851796
75Panhypogammaglobulinemia (HP:0003139)2.20400533
76Prostate neoplasm (HP:0100787)2.18556882
77Osteolytic defects of the phalanges of the hand (HP:0009771)2.18112708
78Osteolytic defects of the hand bones (HP:0009699)2.18112708
79Truncus arteriosus (HP:0001660)2.17844272
80Recurrent fungal infections (HP:0002841)2.15567385
81Aplasia/Hypoplasia of the middle phalanx of the 5th finger (HP:0009161)2.14641580
82Centrally nucleated skeletal muscle fibers (HP:0003687)2.14537324
83Clubbing of toes (HP:0100760)2.12317654
84Osteomyelitis (HP:0002754)2.11623129
85Absent phalangeal crease (HP:0006109)2.11135006
86Dicarboxylic aciduria (HP:0003215)2.09872775
87Abnormality of dicarboxylic acid metabolism (HP:0010995)2.09872775
88Spontaneous abortion (HP:0005268)2.08866499
89Redundant skin (HP:0001582)2.08674255
90Aplasia/Hypoplasia of the thymus (HP:0010515)2.07349575
91Abnormality of the 2nd finger (HP:0004100)2.06668366
923-Methylglutaconic aciduria (HP:0003535)2.06642661
93Abnormality of the fingertips (HP:0001211)2.06641034
94Chronic sinusitis (HP:0011109)2.05396284
95Short clavicles (HP:0000894)2.05099306
96Vacuolated lymphocytes (HP:0001922)2.04009911
97Squamous cell carcinoma (HP:0002860)2.03750579
98Gastrointestinal inflammation (HP:0004386)2.03722429
99Seborrheic dermatitis (HP:0001051)2.02481568
100Abnormality of the prostate (HP:0008775)2.02474560
101Pancytopenia (HP:0001876)2.01671169
102Chest pain (HP:0100749)2.01497851
103Abnormality of the parietal bone (HP:0002696)2.00903951
104Abnormality of DNA repair (HP:0003254)1.98372712
105Asymmetry of the thorax (HP:0001555)1.96942222
106Cervical subluxation (HP:0003308)1.96806436
107Polygenic inheritance (HP:0010982)1.95268711
108Abnormal isoelectric focusing of serum transferrin (HP:0003160)1.93815509
109Abnormal protein N-linked glycosylation (HP:0012347)1.93815509
110Abnormal protein glycosylation (HP:0012346)1.93815509
111Abnormal glycosylation (HP:0012345)1.93815509
112Thin bony cortex (HP:0002753)1.92785747
113Erythema (HP:0010783)1.92050660
114Abnormality of the phalanges of the 5th finger (HP:0004213)1.91677784
115Decreased electroretinogram (ERG) amplitude (HP:0000654)1.90796679
116Chronic mucocutaneous candidiasis (HP:0002728)1.89657937
117Recurrent cutaneous fungal infections (HP:0011370)1.89657937
118Microretrognathia (HP:0000308)1.89553993
119Inflammation of the large intestine (HP:0002037)1.89085995
120Metaphyseal dysplasia (HP:0100255)1.87646043
121Purpura (HP:0000979)1.87265957
122Recurrent viral infections (HP:0004429)1.86930703
123Constricted visual fields (HP:0001133)1.86460209
124Myopathic facies (HP:0002058)1.86053084
125Bone marrow hypocellularity (HP:0005528)1.85478567
126Transposition of the great arteries (HP:0001669)1.85131354
127Abnormal connection of the cardiac segments (HP:0011545)1.85131354
128Abnormal ventriculo-arterial connection (HP:0011563)1.85131354
129Neoplasm of the adrenal cortex (HP:0100641)1.84831585
130Aplasia/Hypoplasia of the sacrum (HP:0008517)1.84806543
131Muscle stiffness (HP:0003552)1.84684233
132Ragged-red muscle fibers (HP:0003200)1.84278612
133Exercise-induced myalgia (HP:0003738)1.83925169
134Birth length less than 3rd percentile (HP:0003561)1.82532429
135Arterial thrombosis (HP:0004420)1.81932829
136Abnormality of the distal phalanges of the toes (HP:0010182)1.81350169
137Eosinophilia (HP:0001880)1.81067351
138Abnormality of the 4th metacarpal (HP:0010012)1.80966913
139Progressive muscle weakness (HP:0003323)1.80955750
140Symphalangism affecting the phalanges of the hand (HP:0009773)1.80460740
14111 pairs of ribs (HP:0000878)1.79338699
142Hyperthyroidism (HP:0000836)1.78882229
143Muscle fiber atrophy (HP:0100295)1.78739227
144Type 2 muscle fiber atrophy (HP:0003554)1.78645202
145Calcaneovalgus deformity (HP:0001848)1.77809088
146Facial diplegia (HP:0001349)1.77710077
147Colon cancer (HP:0003003)1.76643994
148Amaurosis fugax (HP:0100576)1.76577374
149Aplasia/Hypoplasia of the phalanges of the 5th finger (HP:0009376)1.75326693
150Menorrhagia (HP:0000132)1.75101642
151Increased IgE level (HP:0003212)1.73938733
152Abnormality of the heme biosynthetic pathway (HP:0010472)1.70261886
153Thoracic kyphosis (HP:0002942)1.69922191
154Broad palm (HP:0001169)1.69806198
155Encephalitis (HP:0002383)1.69335588
156Bowed forearm bones (HP:0003956)1.68599939
157Bowing of the arm (HP:0006488)1.68599939
158Cheilitis (HP:0100825)1.67848426
159Chronic obstructive pulmonary disease (HP:0006510)1.67562677
160Obstructive lung disease (HP:0006536)1.67562677
161Episodic fever (HP:0001954)1.66783985
162Mediastinal lymphadenopathy (HP:0100721)1.66513386

Predicted kinase interactions (KEA)

RankGene SetZ-score
1FLT34.71363882
2PKN24.28171437
3KIT4.00848632
4EEF2K3.08627329
5CSF1R2.87186141
6TRIB32.65078354
7TEC2.48908096
8MAP4K12.36733174
9TAOK32.25865357
10NME22.11873480
11BTK2.10937133
12ADRBK22.08258774
13PIM22.04814882
14WEE12.01434736
15VRK22.00257738
16TNIK1.91127799
17MAP2K31.84356821
18STK161.76297558
19LRRK21.75152677
20CDK191.72443006
21GRK61.71766792
22RPS6KB21.67593885
23BUB11.62178867
24NUAK11.58926114
25IRAK41.56124175
26MAPKAPK31.54659507
27FES1.54334821
28MATK1.49922535
29PBK1.47972255
30MAP3K131.47157745
31SMG11.46319156
32TGFBR11.45855823
33MAP3K141.43690217
34TBK11.42284024
35IRAK31.40478040
36ERN11.39573155
37BLK1.36690611
38MKNK11.24916658
39SCYL21.24563038
40TLK11.19440258
41SYK1.18128660
42PAK41.16249758
43NEK21.13902725
44ZAP701.13559918
45DYRK31.08298579
46CHEK21.07897537
47MUSK1.07571755
48TAF11.06284513
49TGFBR21.04935893
50BRSK21.04822296
51ZAK1.04519398
52MAP3K121.02277908
53EIF2AK31.00540293
54BCKDK0.98595959
55ABL20.97405998
56CDK30.95295951
57AKT30.95067759
58RPS6KA50.93877882
59TYK20.93581431
60JAK30.92895623
61MST1R0.92568708
62CDC70.91947819
63MAPKAPK50.91058344
64PASK0.91022845
65MAP2K60.89895742
66CDK70.89230189
67EIF2AK20.88539455
68MAP3K60.86830552
69CAMKK20.86630310
70PRKG20.85454637
71PIM10.82078701
72ACVR1B0.80739551
73PIK3CG0.77864584
74ILK0.77611611
75MAP2K20.76797613
76LYN0.74272329
77HIPK20.73445133
78PTK60.73424764
79STK100.72430045
80LCK0.71965515
81SIK20.70503120
82CDK80.70356021
83PINK10.69294616
84OBSCN0.68610606
85CDK90.68477841
86ATR0.68464221
87CLK10.65441478
88RPS6KA40.64560056
89MAPK40.64083287
90DAPK10.62619146
91TNK20.61205625
92RIPK40.60630846
93CAMKK10.60457761
94IKBKE0.60201929
95CHEK10.59938130
96RAF10.59293636
97MAPK110.58990759
98MAPK150.56933417
99CDK40.54971053
100TRPM70.52982288
101TXK0.52290423
102TIE10.51854025
103ITK0.51135814
104HCK0.50984906
105PRPF4B0.49585409
106CDK20.49495708
107BRD40.49292099
108MYLK0.49224896
109KDR0.49194630
110RPS6KA60.48764731
111MAP3K50.48486623
112IRAK20.48443555
113CCNB10.47526820
114CDK120.47418818
115MAP3K80.46815476
116CSNK2A20.46113181
117AURKA0.45741426
118MAP3K110.45558131
119PRKCQ0.44889230
120MAP3K70.44158166
121PAK20.44027302
122RPS6KC10.43319983
123RPS6KL10.43319983
124PLK10.42967508
125CSNK2A10.41924709
126YES10.41921145
127EPHB10.41544046
128MKNK20.41342542
129VRK10.40961898
130TESK20.40439122
131AKT20.40408585
132STK240.39105745
133ATM0.38899840
134IKBKB0.38478752
135AURKB0.38346979
136SRPK10.34949972
137NLK0.33839132
138CDK60.33460783
139CAMK10.32881476
140RPS6KA20.32342519

Predicted pathways (KEGG)

RankGene SetZ-score
1Ribosome_Homo sapiens_hsa030104.85141006
2DNA replication_Homo sapiens_hsa030304.24574325
3Mismatch repair_Homo sapiens_hsa034302.78878491
4Butirosin and neomycin biosynthesis_Homo sapiens_hsa005242.63912910
5Base excision repair_Homo sapiens_hsa034102.63170309
6Homologous recombination_Homo sapiens_hsa034402.15235445
7Leishmaniasis_Homo sapiens_hsa051401.89711735
8* Transcriptional misregulation in cancer_Homo sapiens_hsa052021.89046701
9Pentose phosphate pathway_Homo sapiens_hsa000301.87519816
10Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005331.83934307
11Primary immunodeficiency_Homo sapiens_hsa053401.82200508
12Spliceosome_Homo sapiens_hsa030401.79353518
13RIG-I-like receptor signaling pathway_Homo sapiens_hsa046221.72898488
14Other glycan degradation_Homo sapiens_hsa005111.69344115
15Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006011.64939478
16Cytosolic DNA-sensing pathway_Homo sapiens_hsa046231.60656740
17Galactose metabolism_Homo sapiens_hsa000521.60113259
18Nucleotide excision repair_Homo sapiens_hsa034201.59128156
19Asthma_Homo sapiens_hsa053101.58579870
20Pyrimidine metabolism_Homo sapiens_hsa002401.57159568
21Acute myeloid leukemia_Homo sapiens_hsa052211.56332476
22Herpes simplex infection_Homo sapiens_hsa051681.50764259
23N-Glycan biosynthesis_Homo sapiens_hsa005101.50656549
24Non-homologous end-joining_Homo sapiens_hsa034501.44869164
25Fructose and mannose metabolism_Homo sapiens_hsa000511.44600817
26Antigen processing and presentation_Homo sapiens_hsa046121.43724739
27Thyroid cancer_Homo sapiens_hsa052161.38341351
28Cell cycle_Homo sapiens_hsa041101.37485579
29mRNA surveillance pathway_Homo sapiens_hsa030151.31617848
30Glycosaminoglycan degradation_Homo sapiens_hsa005311.29686858
31Central carbon metabolism in cancer_Homo sapiens_hsa052301.27949778
32Cyanoamino acid metabolism_Homo sapiens_hsa004601.24007692
33Hematopoietic cell lineage_Homo sapiens_hsa046401.23354141
34Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030081.23122666
35Sulfur relay system_Homo sapiens_hsa041221.21742121
36Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006301.21685913
37B cell receptor signaling pathway_Homo sapiens_hsa046621.21150632
38Cysteine and methionine metabolism_Homo sapiens_hsa002701.18428642
39RNA degradation_Homo sapiens_hsa030181.13650386
40Jak-STAT signaling pathway_Homo sapiens_hsa046301.12677463
41Systemic lupus erythematosus_Homo sapiens_hsa053221.12054014
42Measles_Homo sapiens_hsa051621.11836336
43Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa009701.10339061
44Platelet activation_Homo sapiens_hsa046111.04328692
45Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa005201.03958968
46Inflammatory bowel disease (IBD)_Homo sapiens_hsa053211.03034822
47Fc epsilon RI signaling pathway_Homo sapiens_hsa046641.03027434
48RNA transport_Homo sapiens_hsa030131.01725797
49Selenocompound metabolism_Homo sapiens_hsa004501.01639391
50Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006041.01223737
51Renin-angiotensin system_Homo sapiens_hsa046141.00769407
52RNA polymerase_Homo sapiens_hsa030200.99845924
53Protein export_Homo sapiens_hsa030600.98983257
54Legionellosis_Homo sapiens_hsa051340.98561671
55Folate biosynthesis_Homo sapiens_hsa007900.97679540
56Intestinal immune network for IgA production_Homo sapiens_hsa046720.96639338
57Other types of O-glycan biosynthesis_Homo sapiens_hsa005140.96309618
58Leukocyte transendothelial migration_Homo sapiens_hsa046700.92875792
59NOD-like receptor signaling pathway_Homo sapiens_hsa046210.91918729
60Glycolysis / Gluconeogenesis_Homo sapiens_hsa000100.90066327
61Influenza A_Homo sapiens_hsa051640.89520018
62Shigellosis_Homo sapiens_hsa051310.88210317
63p53 signaling pathway_Homo sapiens_hsa041150.87920443
64Fc gamma R-mediated phagocytosis_Homo sapiens_hsa046660.86032728
65Pentose and glucuronate interconversions_Homo sapiens_hsa000400.85733334
66Fanconi anemia pathway_Homo sapiens_hsa034600.83134553
67Basal transcription factors_Homo sapiens_hsa030220.80074508
68Natural killer cell mediated cytotoxicity_Homo sapiens_hsa046500.78551561
69Toll-like receptor signaling pathway_Homo sapiens_hsa046200.77091257
70Purine metabolism_Homo sapiens_hsa002300.75802653
71Osteoclast differentiation_Homo sapiens_hsa043800.75006349
72Graft-versus-host disease_Homo sapiens_hsa053320.74287394
73Chronic myeloid leukemia_Homo sapiens_hsa052200.74124005
74Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate_Homo sapiens_hsa005320.74108687
75Pertussis_Homo sapiens_hsa051330.73507565
76Biosynthesis of amino acids_Homo sapiens_hsa012300.73467698
77Apoptosis_Homo sapiens_hsa042100.72877507
78Non-small cell lung cancer_Homo sapiens_hsa052230.72860851
79HIF-1 signaling pathway_Homo sapiens_hsa040660.71491189
80Toxoplasmosis_Homo sapiens_hsa051450.70231003
81Hepatitis B_Homo sapiens_hsa051610.70014908
82Glycerophospholipid metabolism_Homo sapiens_hsa005640.67692121
83Proteasome_Homo sapiens_hsa030500.67412014
84One carbon pool by folate_Homo sapiens_hsa006700.65866201
85Starch and sucrose metabolism_Homo sapiens_hsa005000.65823375
86Longevity regulating pathway - multiple species_Homo sapiens_hsa042130.65527627
87NF-kappa B signaling pathway_Homo sapiens_hsa040640.65409592
88Regulation of autophagy_Homo sapiens_hsa041400.63331064
89Autoimmune thyroid disease_Homo sapiens_hsa053200.61961276
90Chagas disease (American trypanosomiasis)_Homo sapiens_hsa051420.61399625
91Carbon metabolism_Homo sapiens_hsa012000.60853789
92Malaria_Homo sapiens_hsa051440.60813539
93Pathogenic Escherichia coli infection_Homo sapiens_hsa051300.59878464
94mTOR signaling pathway_Homo sapiens_hsa041500.59464757
95Bladder cancer_Homo sapiens_hsa052190.58247594
96ABC transporters_Homo sapiens_hsa020100.58201371
97Drug metabolism - other enzymes_Homo sapiens_hsa009830.57031982
98Glutathione metabolism_Homo sapiens_hsa004800.56640781
99Ubiquitin mediated proteolysis_Homo sapiens_hsa041200.56119792
100Viral carcinogenesis_Homo sapiens_hsa052030.55438708
101Longevity regulating pathway - mammal_Homo sapiens_hsa042110.55320815
102Sulfur metabolism_Homo sapiens_hsa009200.55001947
103Tuberculosis_Homo sapiens_hsa051520.54438034
104Valine, leucine and isoleucine degradation_Homo sapiens_hsa002800.53042476
105Epstein-Barr virus infection_Homo sapiens_hsa051690.52179765
106Regulation of lipolysis in adipocytes_Homo sapiens_hsa049230.51128061
107SNARE interactions in vesicular transport_Homo sapiens_hsa041300.51069484
108Type I diabetes mellitus_Homo sapiens_hsa049400.50822895
109Amyotrophic lateral sclerosis (ALS)_Homo sapiens_hsa050140.50221390
110Cytokine-cytokine receptor interaction_Homo sapiens_hsa040600.50071420
111Arachidonic acid metabolism_Homo sapiens_hsa005900.48219568
112Peroxisome_Homo sapiens_hsa041460.47888001
113Small cell lung cancer_Homo sapiens_hsa052220.47768733
114African trypanosomiasis_Homo sapiens_hsa051430.47768422
115Neurotrophin signaling pathway_Homo sapiens_hsa047220.47077028
116VEGF signaling pathway_Homo sapiens_hsa043700.46262841
117Hepatitis C_Homo sapiens_hsa051600.45959118
118HTLV-I infection_Homo sapiens_hsa051660.42691077
119Allograft rejection_Homo sapiens_hsa053300.42647933
120Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005630.42401839
121Salmonella infection_Homo sapiens_hsa051320.42339043
122Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007600.39969860
123Progesterone-mediated oocyte maturation_Homo sapiens_hsa049140.39747734
124Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001300.38426511
125Olfactory transduction_Homo sapiens_hsa047400.38094311
126Pancreatic cancer_Homo sapiens_hsa052120.36903226
127Adipocytokine signaling pathway_Homo sapiens_hsa049200.36730744
128Carbohydrate digestion and absorption_Homo sapiens_hsa049730.35909819
129Ether lipid metabolism_Homo sapiens_hsa005650.33813015
130Metabolic pathways_Homo sapiens_hsa011000.32758063
131Insulin resistance_Homo sapiens_hsa049310.30927253
132Arginine and proline metabolism_Homo sapiens_hsa003300.30452317
133Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008600.29802740
134Melanoma_Homo sapiens_hsa052180.29508388
1352-Oxocarboxylic acid metabolism_Homo sapiens_hsa012100.26761986
136Lysine degradation_Homo sapiens_hsa003100.22755919
137Propanoate metabolism_Homo sapiens_hsa006400.22146179
138Parkinsons disease_Homo sapiens_hsa050120.20295874

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