HOXB13

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: This gene encodes a transcription factor that belongs to the homeobox gene family. Genes of this family are highly conserved among vertebrates and essential for vertebrate embryonic development. This gene has been implicated to play a role in fetal skin development and cutaneous regeneration. In mice, a similar gene was shown to exhibit temporal and spatial colinearity in the main body axis of the embryo, but was not expressed in the secondary axes, which suggests functions in body patterning along the axis. This gene and other HOXB genes form a gene cluster at chromosome the 17q21-22 region. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1UDP-N-acetylglucosamine metabolic process (GO:0006047)8.86656974
2* branching involved in prostate gland morphogenesis (GO:0060442)7.52413793
3regulation of epithelial cell proliferation involved in prostate gland development (GO:0060768)7.31735255
4Golgi transport vesicle coating (GO:0048200)7.25208095
5COPI coating of Golgi vesicle (GO:0048205)7.25208095
6L-fucose catabolic process (GO:0042355)7.10057983
7fucose catabolic process (GO:0019317)7.10057983
8L-fucose metabolic process (GO:0042354)7.10057983
9intestinal epithelial cell development (GO:0060576)6.89209128
10artery development (GO:0060840)6.60487636
11biotin metabolic process (GO:0006768)6.54153663
12maintenance of protein localization in endoplasmic reticulum (GO:0035437)6.47924179
13mannose metabolic process (GO:0006013)6.17573512
14galactose catabolic process (GO:0019388)5.99702149
15fucose metabolic process (GO:0006004)5.93481138
16epithelial cell differentiation involved in prostate gland development (GO:0060742)5.57051085
17protein retention in ER lumen (GO:0006621)5.54586483
18endothelial cell chemotaxis (GO:0035767)5.53939047
19mitotic cell cycle arrest (GO:0071850)5.52439664
20regulation of receptor binding (GO:1900120)5.50302023
21activation of signaling protein activity involved in unfolded protein response (GO:0006987)5.22857085
22ER-associated ubiquitin-dependent protein catabolic process (GO:0030433)5.19864380
23iron ion import (GO:0097286)5.16882331
24nucleotide-sugar biosynthetic process (GO:0009226)5.09429051
25* prostate gland epithelium morphogenesis (GO:0060740)5.08177457
26lung secretory cell differentiation (GO:0061140)5.05043147
27nucleotide-sugar metabolic process (GO:0009225)5.02075797
28N-glycan processing (GO:0006491)5.00601782
29positive regulation of nuclease activity (GO:0032075)5.00536245
30angiotensin maturation (GO:0002003)4.87154468
31pyrimidine-containing compound transmembrane transport (GO:0072531)4.62033992
32regulation of nuclease activity (GO:0032069)4.51343720
33positive regulation of steroid hormone secretion (GO:2000833)4.47659111
34beta-amyloid metabolic process (GO:0050435)4.40326312
35endoplasmic reticulum unfolded protein response (GO:0030968)4.39902533
36GDP-mannose metabolic process (GO:0019673)4.34743779
37carnitine shuttle (GO:0006853)4.34534409
38vitamin transmembrane transport (GO:0035461)4.33689087
39cellular response to unfolded protein (GO:0034620)4.24203164
40positive regulation of transcription from RNA polymerase III promoter (GO:0045945)4.17822946
41valine metabolic process (GO:0006573)4.17425825
42COPII vesicle coating (GO:0048208)4.16504939
43retrograde vesicle-mediated transport, Golgi to ER (GO:0006890)4.15667795
44hemidesmosome assembly (GO:0031581)4.13438755
45protein autoprocessing (GO:0016540)4.13070249
46apoptotic cell clearance (GO:0043277)4.06278730
47ER-nucleus signaling pathway (GO:0006984)4.02781405
48response to endoplasmic reticulum stress (GO:0034976)3.98359367
49glandular epithelial cell differentiation (GO:0002067)3.94452514
50cellular response to topologically incorrect protein (GO:0035967)3.93093995
51intrinsic apoptotic signaling pathway in response to endoplasmic reticulum stress (GO:0070059)3.86227030
52transcytosis (GO:0045056)3.86198263
53positive regulation of natural killer cell differentiation (GO:0032825)3.83002631
54* response to testosterone (GO:0033574)3.81696147
55fatty acid transmembrane transport (GO:1902001)3.81631919
56protein N-linked glycosylation via asparagine (GO:0018279)3.81160831
57pharyngeal system development (GO:0060037)3.81133327
58galactose metabolic process (GO:0006012)3.79936802
59peptidyl-asparagine modification (GO:0018196)3.79289914
60hexose catabolic process (GO:0019320)3.78671774
61opsonization (GO:0008228)3.74782196
62activation of transmembrane receptor protein tyrosine kinase activity (GO:0007171)3.71667754
63sulfur amino acid catabolic process (GO:0000098)3.71006253
64fucosylation (GO:0036065)3.66324026
65hormone catabolic process (GO:0042447)3.61879429
66auditory receptor cell differentiation (GO:0042491)3.59417526
67potassium ion homeostasis (GO:0055075)3.57915944
68positive regulation of actin filament depolymerization (GO:0030836)3.55835933
69insulin-like growth factor receptor signaling pathway (GO:0048009)3.50343338
70protein N-linked glycosylation (GO:0006487)3.47479941
71sex differentiation (GO:0007548)3.46666829
72carnitine transmembrane transport (GO:1902603)3.46379498
73regulation of fatty acid beta-oxidation (GO:0031998)3.43430687
74vesicle coating (GO:0006901)3.41073945
75regulation of cell-cell adhesion mediated by cadherin (GO:2000047)3.37713298
76positive regulation of growth hormone secretion (GO:0060124)3.37524083
77L-serine metabolic process (GO:0006563)3.36328110
78positive regulation of histone deacetylation (GO:0031065)3.34735817
79fatty acid beta-oxidation using acyl-CoA oxidase (GO:0033540)3.33599653
80response to unfolded protein (GO:0006986)3.33083598
81desmosome organization (GO:0002934)3.32611774
82regulation of growth hormone secretion (GO:0060123)3.31712785
83bundle of His cell to Purkinje myocyte communication (GO:0086069)3.26826482
84positive regulation of intracellular steroid hormone receptor signaling pathway (GO:0033145)3.25461809
85acetyl-CoA metabolic process (GO:0006084)3.25078046
86regulation of pH (GO:0006885)3.24299072
87L-serine transport (GO:0015825)3.22649447
88import into cell (GO:0098657)3.22597691
89zinc ion transport (GO:0006829)3.22072195
90cellular ketone body metabolic process (GO:0046950)3.21580360
91cerebellar Purkinje cell layer development (GO:0021680)3.21297454
92negative regulation of glycogen biosynthetic process (GO:0045719)3.21202965
93regulation of acrosome reaction (GO:0060046)3.18188244
94protein localization to synapse (GO:0035418)3.14710989
95regulation of insulin-like growth factor receptor signaling pathway (GO:0043567)3.11084674
96response to topologically incorrect protein (GO:0035966)3.11069543
97glucosamine-containing compound metabolic process (GO:1901071)3.09243686
98dorsal/ventral neural tube patterning (GO:0021904)3.08244728
99amino-acid betaine transport (GO:0015838)3.08079226
100carnitine transport (GO:0015879)3.08079226
101sequestering of metal ion (GO:0051238)3.07954749
102peptidyl-tyrosine autophosphorylation (GO:0038083)3.07717970
103negative regulation of sterol transport (GO:0032372)3.07652473
104negative regulation of cholesterol transport (GO:0032375)3.07652473
105fusion of sperm to egg plasma membrane (GO:0007342)3.07449126
106positive regulation of CREB transcription factor activity (GO:0032793)3.07191479
107lung cell differentiation (GO:0060479)3.06745552
108lipopolysaccharide biosynthetic process (GO:0009103)3.06544816
109sulfur compound transport (GO:0072348)3.05186111
110actin filament depolymerization (GO:0030042)3.00855048
111cerebellar granule cell differentiation (GO:0021707)3.00345143
112monosaccharide catabolic process (GO:0046365)2.98566682
113positive regulation of fatty acid beta-oxidation (GO:0032000)2.96895463
114regulation of hippo signaling (GO:0035330)2.96806925
115adhesion of symbiont to host cell (GO:0044650)2.95804247
116virion attachment to host cell (GO:0019062)2.95804247
117negative regulation of cell size (GO:0045792)2.95504930
118calcium-independent cell-cell adhesion via plasma membrane cell-adhesion molecules (GO:0016338)2.95235796
119positive regulation of fatty acid oxidation (GO:0046321)2.94743813
120lung epithelial cell differentiation (GO:0060487)2.93392205
121misfolded or incompletely synthesized protein catabolic process (GO:0006515)2.91846736
122peptide cross-linking (GO:0018149)2.91618373
123amino sugar metabolic process (GO:0006040)2.90581384
124mRNA cleavage (GO:0006379)2.89217732
125coronary vasculature morphogenesis (GO:0060977)2.88650270
126quaternary ammonium group transport (GO:0015697)2.87926415
127long-chain fatty-acyl-CoA biosynthetic process (GO:0035338)2.87278699
128coenzyme A biosynthetic process (GO:0015937)2.87032024
129diol metabolic process (GO:0034311)2.86640354
130positive regulation of catenin import into nucleus (GO:0035413)2.85985578
131regulation of steroid hormone secretion (GO:2000831)2.85225165
132positive regulation of glycoprotein metabolic process (GO:1903020)2.80419443
133extracellular matrix assembly (GO:0085029)2.80138260
134polyamine biosynthetic process (GO:0006596)2.79840401
135sulfate transmembrane transport (GO:1902358)2.79501953
136regulation of membrane protein ectodomain proteolysis (GO:0051043)2.78720286
137ketone body metabolic process (GO:1902224)2.76817633
138adaptation of signaling pathway (GO:0023058)2.76687458
139cytoskeletal anchoring at plasma membrane (GO:0007016)2.76374040
140branched-chain amino acid catabolic process (GO:0009083)2.75407082
141glucocorticoid receptor signaling pathway (GO:0042921)2.75382079
142epithelial cell-cell adhesion (GO:0090136)2.74471010
143phenol-containing compound catabolic process (GO:0019336)2.74153327
144peptidyl-proline hydroxylation (GO:0019511)2.73694017
145positive regulation of action potential (GO:0045760)2.73215917
146righting reflex (GO:0060013)2.71804919
147protein targeting to Golgi (GO:0000042)2.70839028
148regulation of Arp2/3 complex-mediated actin nucleation (GO:0034315)2.68059502
149opioid receptor signaling pathway (GO:0038003)2.66598316
150response to misfolded protein (GO:0051788)2.64048751
151positive regulation of excitatory postsynaptic membrane potential (GO:2000463)2.61640130
152negative regulation of translation, ncRNA-mediated (GO:0040033)2.61012148
153regulation of translation, ncRNA-mediated (GO:0045974)2.61012148
154negative regulation of translation involved in gene silencing by miRNA (GO:0035278)2.61012148
155purine nucleoside bisphosphate biosynthetic process (GO:0034033)2.60770017
156ribonucleoside bisphosphate biosynthetic process (GO:0034030)2.60770017
157nucleoside bisphosphate biosynthetic process (GO:0033866)2.60770017
158homocysteine metabolic process (GO:0050667)2.60244073
159alpha-linolenic acid metabolic process (GO:0036109)2.59875728
160establishment or maintenance of epithelial cell apical/basal polarity (GO:0045197)2.59478383
161negative regulation of cell fate commitment (GO:0010454)2.58825155
162muscle cell fate commitment (GO:0042693)2.58822480
163copper ion transport (GO:0006825)2.58733253
164multicellular organismal movement (GO:0050879)2.57285518
165musculoskeletal movement (GO:0050881)2.57285518
166fatty-acyl-CoA biosynthetic process (GO:0046949)2.55005093
167vascular endothelial growth factor signaling pathway (GO:0038084)2.53741846
168regulation of Wnt signaling pathway involved in heart development (GO:0003307)2.52665015
169multicellular organism reproduction (GO:0032504)2.51479521
170coenzyme A metabolic process (GO:0015936)2.51146047
171cellular biogenic amine biosynthetic process (GO:0042401)2.50856613
172reflex (GO:0060004)2.50628630
173regulation of mesenchymal cell apoptotic process (GO:2001053)2.49584741
174neurotransmitter catabolic process (GO:0042135)2.48906858
175acyl-CoA biosynthetic process (GO:0071616)2.47931642
176thioester biosynthetic process (GO:0035384)2.47931642
177regulation of fatty acid oxidation (GO:0046320)2.47823493
178proline biosynthetic process (GO:0006561)2.47445807
179serine family amino acid biosynthetic process (GO:0009070)2.44078666
180neuron fate specification (GO:0048665)2.42434693
181DNA methylation involved in gamete generation (GO:0043046)2.41954272

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1TP63_17297297_ChIP-ChIP_HaCaT_Human6.30835263
2EZH2_22144423_ChIP-Seq_EOC_Human4.10829541
3AR_21572438_ChIP-Seq_LNCaP_Human4.00538787
4PIAS1_25552417_ChIP-Seq_VCAP_Human3.84428049
5SOX2_27498859_Chip-Seq_STOMACH_Mouse3.67933335
6ZNF263_19887448_ChIP-Seq_K562_Human3.09389287
7FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse3.07283703
8ESR2_21235772_ChIP-Seq_MCF-7_Human2.99812110
9SMAD4_19686287_ChIP-ChIP_HaCaT_Human2.95123327
10SOX2_20726797_ChIP-Seq_SW620_Human2.94945701
11CDX2_20551321_ChIP-Seq_CACO-2_Human2.92853083
12TRIM28_21343339_ChIP-Seq_HEK293_Human2.92825424
13STAT6_21828071_ChIP-Seq_BEAS2B_Human2.75497393
14TRP63_18441228_ChIP-ChIP_KERATINOCYTES_Mouse2.70413810
15CLOCK_20551151_ChIP-Seq_293T_Human2.68808548
16ESR1_21235772_ChIP-Seq_MCF-7_Human2.66866377
17VDR_22108803_ChIP-Seq_LS180_Human2.60527146
18GATA6_25053715_ChIP-Seq_YYC3_Human2.56464807
19ESR1_20079471_ChIP-ChIP_T-47D_Human2.51139665
20ZFP322A_24550733_ChIP-Seq_MESCs_Mouse2.49526188
21* SMARCA4_20176728_ChIP-ChIP_TSCs_Mouse2.48314918
22GATA4_25053715_ChIP-Seq_YYC3_Human2.47588529
23* CBX2_27304074_Chip-Seq_ESCs_Mouse2.41010687
24NR4A2_19515692_ChIP-ChIP_MN9D_Mouse2.39118993
25IGF1R_20145208_ChIP-Seq_DFB_Human2.36559402
26STAT5_23275557_ChIP-Seq_MAMMARY-EPITHELIUM_Mouse2.36175879
27CHD7_19251738_ChIP-ChIP_MESCs_Mouse2.32398379
28FOXO3_23340844_ChIP-Seq_DLD1_Human2.32038515
29CTNNB1_20615089_ChIP-ChIP_FETAL_BRAIN_Human2.31604375
30KLF6_26769127_Chip-Seq_PDAC-Cell_line_Human2.28112742
31RARG_19884340_ChIP-ChIP_MEFs_Mouse2.22572935
32FOXA1_21915096_ChIP-Seq_LNCaP-1F5_Human2.16344226
33ESR1_17901129_ChIP-ChIP_LIVER_Mouse2.15941300
34SMAD3_18955504_ChIP-ChIP_HaCaT_Human2.12835884
35SMAD2_18955504_ChIP-ChIP_HaCaT_Human2.12835884
36AR_21915096_ChIP-Seq_LNCaP-1F5_Human2.12828947
37ELF3_26769127_Chip-Seq_PDAC-Cell_line_Human1.99517156
38ZNF217_24962896_ChIP-Seq_MCF-7_Human1.98537145
39RUNX1_27514584_Chip-Seq_MCF-7_Human1.96863754
40NUCKS1_24931609_ChIP-Seq_HEPATOCYTES_Mouse1.89488187
41DROSHA_22980978_ChIP-Seq_HELA_Human1.88370507
42AR_21909140_ChIP-Seq_LNCAP_Human1.87451922
43CDX2_19796622_ChIP-Seq_MESCs_Mouse1.87423851
44HNF4A_19761587_ChIP-ChIP_CACO-2_Human1.87195438
45ATF3_27146783_Chip-Seq_COLON_Human1.85736531
46TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat1.85702558
47HIF1A_21447827_ChIP-Seq_MCF-7_Human1.79383638
48POU5F1_18700969_ChIP-ChIP_MESCs_Mouse1.79043194
49RACK7_27058665_Chip-Seq_MCF-7_Human1.78817413
50ETS2_20176728_ChIP-ChIP_TROPHOBLAST_STEM_CELLS_Mouse1.78467632
51AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human1.76954673
52KDM5A_27292631_Chip-Seq_BREAST_Human1.76920391
53PPAR_26484153_Chip-Seq_NCI-H1993_Human1.76116318
54* EZH2_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse1.75708072
55JARID2_20075857_ChIP-Seq_MESCs_Mouse1.75121886
56CHD1_26751641_Chip-Seq_LNCaP_Human1.73557080
57FOXA1_27197147_Chip-Seq_ENDOMETRIOID-ADENOCARCINOMA_Human1.72624113
58GATA3_24758297_ChIP-Seq_MCF-7_Human1.71177745
59GATA1_22025678_ChIP-Seq_K562_Human1.68585946
60TFAP2C_20629094_ChIP-Seq_MCF-7_Human1.64222243
61LXR_22292898_ChIP-Seq_THP-1_Human1.57911975
62PPARA_22158963_ChIP-Seq_LIVER_Mouse1.55761844
63ERA_27197147_Chip-Seq_ENDOMETRIOID-ADENOCARCINOMA_Human1.55483367
64* EED_16625203_ChIP-ChIP_MESCs_Mouse1.52219397
65FOXA1_26769127_Chip-Seq_PDAC-Cell_line_Human1.51336352
66KLF5_25053715_ChIP-Seq_YYC3_Human1.50920569
67MYCN_19997598_ChIP-ChIP_NEUROBLASTOMA_Human1.50144816
68KLF4_26769127_Chip-Seq_PDAC-Cell_line_Human1.48207540
69TCF21_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human1.47280639
70* CREB1_26743006_Chip-Seq_LNCaP_Human1.44801554
71* EZH2_27304074_Chip-Seq_ESCs_Mouse1.42439426
72CREB1_26743006_Chip-Seq_LNCaP-abl_Human1.40178919
73* EZH2_27294783_Chip-Seq_ESCs_Mouse1.39837314
74ERG_20517297_ChIP-Seq_VCAP_Human1.37300471
75ELF5_23300383_ChIP-Seq_T47D_Human1.37071695
76P68_20966046_ChIP-Seq_HELA_Human1.32199662
77* RING1B_27294783_Chip-Seq_NPCs_Mouse1.30146817
78AHR_22903824_ChIP-Seq_MCF-7_Human1.27241994
79CTCF_27219007_Chip-Seq_Bcells_Human1.26814931
80CEBPB_21427703_ChIP-Seq_3T3-L1_Mouse1.24579084
81NRF2_20460467_ChIP-Seq_MEFs_Mouse1.24387203
82NFE2L2_20460467_ChIP-Seq_MEFs_Mouse1.24387203
83FOXA1_25552417_ChIP-Seq_VCAP_Human1.24129754
84SALL4_18804426_ChIP-ChIP_XEN_Mouse1.24029478
85TCFAP2C_20176728_ChIP-ChIP_TROPHOBLAST_STEM_CELLS_Mouse1.23952100
86SMC4_20622854_ChIP-Seq_HELA_Human1.23780587
87FOXA2_19822575_ChIP-Seq_HepG2_Human1.23022330
88ZNF652_21678463_ChIP-ChIP_ZR75-1_Human1.22769419
89DMRT1_21621532_ChIP-ChIP_FETAL_Ovary1.21897615
90SIN3A_21632747_ChIP-Seq_MESCs_Mouse1.21710713
91LXR_22158963_ChIP-Seq_LIVER_Mouse1.21341709
92RUNX2_24764292_ChIP-Seq_MC3T3_Mouse1.20878881
93* TP53_20018659_ChIP-ChIP_R1E_Mouse1.19778735
94RXR_22158963_ChIP-Seq_LIVER_Mouse1.19631050
95PPARG_19300518_ChIP-PET_3T3-L1_Mouse1.19317195
96OCT1_27270436_Chip-Seq_PROSTATE_Human1.19212034
97PPARD_23208498_ChIP-Seq_MDA-MB-231_Human1.18971294
98* BMI1_23680149_ChIP-Seq_NPCS_Mouse1.18352751
99ZNF274_21170338_ChIP-Seq_K562_Hela1.18249280
100CJUN_26792858_Chip-Seq_BT549_Human1.16140039
101WDR5_24793694_ChIP-Seq_LNCAP_Human1.16095835
102STAT3_22323479_ChIP-Seq_MACROPHAGE_Mouse1.15774753
103FOXM1_26456572_ChIP-Seq_MCF-7_Human1.15467285
104CTNNB1_20460455_ChIP-Seq_HCT116_Human1.14405161
105SOX9_24532713_ChIP-Seq_HFSC_Mouse1.14154479
106E2F1_20622854_ChIP-Seq_HELA_Human1.13366982
107TP53_22127205_ChIP-Seq_IMR90_Human1.13182458
108MYCN_27167114_Chip-Seq_NEUROBLASTOMA_Human1.12948603
109P300_27058665_Chip-Seq_ZR-75-30cells_Human1.10641757
110AR_25329375_ChIP-Seq_VCAP_Human1.10398140
111PKCTHETA_26484144_Chip-Seq_BREAST_Human1.10342609
112* OCT4_20526341_ChIP-Seq_ESCs_Human1.09475075
113CTBP2_25329375_ChIP-Seq_LNCAP_Human1.09219278
114JUND_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human1.06907338
115ESR1_22446102_ChIP-Seq_UTERUS_Mouse1.06642062
116JARID2_20064375_ChIP-Seq_MESCs_Mouse1.06608146
117BACH1_22875853_ChIP-PCR_HELA_AND_SCP4_Human1.05659773
118* ERA_21632823_ChIP-Seq_H3396_Human1.05495124
119* PHC1_16625203_ChIP-ChIP_MESCs_Mouse1.01774193
120E2F1_17053090_ChIP-ChIP_MCF-7_Human1.01568799
121STAT1_20625510_ChIP-Seq_HELA_Human1.01248756
122* RNF2_27304074_Chip-Seq_NSC_Mouse0.98465536
123* TET1_21451524_ChIP-Seq_MESCs_Mouse0.97925957
124EOMES_20176728_ChIP-ChIP_TSCs_Mouse0.97745018
125TAF7L_23326641_ChIP-Seq_C3H10T1-2_Mouse0.97702520
126ATF3_23680149_ChIP-Seq_GBM1-GSC_Human0.97015428
127* RNF2_18974828_ChIP-Seq_MESCs_Mouse0.95458389
128* EZH2_18974828_ChIP-Seq_MESCs_Mouse0.95458389
129* ELK3_25401928_ChIP-Seq_HUVEC_Human0.94314475
130ERG_21242973_ChIP-ChIP_JURKAT_Human0.94148342
131E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse0.93392867
132* KLF4_18358816_ChIP-ChIP_MESCs_Mouse0.93379154
133* FOXA1_26743006_Chip-Seq_LNCaP-abl_Human0.92738664
134SUZ12_18555785_ChIP-Seq_MESCs_Mouse0.92365440
135ARNT_22903824_ChIP-Seq_MCF-7_Human0.91013740
136TBP_23326641_ChIP-Seq_C3H10T1-2_Mouse0.89204447
137GATA2_21666600_ChIP-Seq_HMVEC_Human0.88146621
138CTBP1_25329375_ChIP-Seq_LNCAP_Human0.87716470
139* SUZ12_16625203_ChIP-ChIP_MESCs_Mouse0.87408394
140CTNNB1_24651522_ChIP-Seq_LGR5+_INTESTINAL_STEM_Human0.87026523
141BCL3_23251550_ChIP-Seq_MUSCLE_Mouse0.85795296
142RAC3_21632823_ChIP-Seq_H3396_Human0.85074081
143P63_26484246_Chip-Seq_KERATINOCYTES_Human0.84782557
144TFAP2A_17053090_ChIP-ChIP_MCF-7_Human0.84520352
145OCT4_19829295_ChIP-Seq_ESCs_Human0.84439331
146NANOG_18555785_ChIP-Seq_MESCs_Mouse0.82977162
147NEUROD2_26341353_ChIP-Seq_CORTEX_Mouse0.82898257
148* SUZ12_27294783_Chip-Seq_ESCs_Mouse0.82789441
149* HNF4A_19822575_ChIP-Seq_HepG2_Human0.82510956
150* TCF3_18467660_ChIP-ChIP_MESCs_Mouse0.82404711
151KDM2B_26808549_Chip-Seq_K562_Human0.82125147
152CTCF_20526341_ChIP-Seq_ESCs_Human0.81609842
153JUN_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human0.81431593
154NR1I2_20693526_ChIP-Seq_LIVER_Mouse0.80438727
155PPARD_23176727_ChIP-Seq_KERATINOCYTES_Mouse0.80233762
156BCL11B_21912641_ChIP-Seq_STHDH_STRIUM_Mouse0.80164153
157REST_21632747_ChIP-Seq_MESCs_Mouse0.79779714
158PHF8_20622854_ChIP-Seq_HELA_Human0.79640048
159TP63_22573176_ChIP-Seq_HFKS_Human0.79147448
160DACH1_20351289_ChIP-Seq_MDA-MB-231_Human0.78845234
161NR3C1_21868756_ChIP-Seq_MCF10A_Human0.78844846
162TBX20_22328084_ChIP-Seq_HEART_Mouse0.78310557
163TBX20_22080862_ChIP-Seq_HEART_Mouse0.78310557
164BCOR_27268052_Chip-Seq_Bcells_Human0.78102608
165RBPJ_21746931_ChIP-Seq_IB4-LCL_Human0.77986486
166RARB_24833708_ChIP-Seq_LIVER_Mouse0.77830508
167CDX2_22108803_ChIP-Seq_LS180_Human0.77116742
168ESR1_15608294_ChIP-ChIP_MCF-7_Human0.76972661
169* RNF2_27304074_Chip-Seq_ESCs_Mouse0.76961446
170POU5F1_18555785_ChIP-Seq_MESCs_Mouse0.76731421
171GATA3_21878914_ChIP-Seq_MCF-7_Human0.76467532
172KDM2B_26808549_Chip-Seq_SIL-ALL_Human0.75449141

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0010234_abnormal_vibrissa_follicle6.79730241
2MP0004858_abnormal_nervous_system4.95160777
3MP0005310_abnormal_salivary_gland4.59955689
4MP0003705_abnormal_hypodermis_morpholog3.88421680
5MP0003300_gastrointestinal_ulcer3.81935748
6MP0000537_abnormal_urethra_morphology3.78068020
7MP0002166_altered_tumor_susceptibility3.53219670
8MP0001873_stomach_inflammation3.22751719
9MP0002234_abnormal_pharynx_morphology3.21647592
10MP0010386_abnormal_urinary_bladder3.16237706
11MP0002822_catalepsy3.07206439
12MP0004145_abnormal_muscle_electrophysio2.93699673
13MP0004264_abnormal_extraembryonic_tissu2.86092866
14MP0005670_abnormal_white_adipose2.67300956
15MP0008438_abnormal_cutaneous_collagen2.66855753
16MP0005451_abnormal_body_composition2.64690323
17MP0002006_tumorigenesis2.62713601
18MP0004043_abnormal_pH_regulation2.52357634
19MP0001765_abnormal_ion_homeostasis2.48575858
20MP0010352_gastrointestinal_tract_polyps2.46632812
21MP0003866_abnormal_defecation2.40756233
22MP0006054_spinal_hemorrhage2.34135636
23MP0000613_abnormal_salivary_gland2.26976763
24MP0009384_cardiac_valve_regurgitation2.25935846
25MP0005275_abnormal_skin_tensile2.25027815
26MP0003011_delayed_dark_adaptation2.24594963
27MP0004233_abnormal_muscle_weight2.17635602
28MP0005645_abnormal_hypothalamus_physiol2.11787810
29MP0002249_abnormal_larynx_morphology2.06102435
30MP0002735_abnormal_chemical_nociception2.03176657
31MP0003879_abnormal_hair_cell2.02166363
32MP0000538_abnormal_urinary_bladder1.98829116
33MP0001756_abnormal_urination1.80165686
34MP0001666_abnormal_nutrient_absorption1.69549402
35MP0005410_abnormal_fertilization1.67223890
36MP0001501_abnormal_sleep_pattern1.66773027
37MP0010155_abnormal_intestine_physiology1.66505233
38MP0000678_abnormal_parathyroid_gland1.64129382
39MP0000462_abnormal_digestive_system1.62846436
40MP0002132_abnormal_respiratory_system1.61875238
41MP0010678_abnormal_skin_adnexa1.60863199
42MP0002653_abnormal_ependyma_morphology1.59790059
43MP0005636_abnormal_mineral_homeostasis1.59187016
44MP0009053_abnormal_anal_canal1.57074404
45MP0002009_preneoplasia1.54273108
46MP0009780_abnormal_chondrocyte_physiolo1.53466983
47MP0004185_abnormal_adipocyte_glucose1.52631180
48MP0002295_abnormal_pulmonary_circulatio1.51228836
49MP0004742_abnormal_vestibular_system1.50469674
50MP0000490_abnormal_crypts_of1.49784501
51MP0005381_digestive/alimentary_phenotyp1.48732501
52MP0001663_abnormal_digestive_system1.48424443
53MP0001485_abnormal_pinna_reflex1.43528301
54MP0003123_paternal_imprinting1.43105652
55MP0005023_abnormal_wound_healing1.41976972
56MP0005058_abnormal_lysosome_morphology1.39569622
57MP0000566_synostosis1.38999379
58MP0005646_abnormal_pituitary_gland1.36984299
59MP0008961_abnormal_basal_metabolism1.36845825
60MP0001299_abnormal_eye_distance/1.36783096
61MP0000477_abnormal_intestine_morphology1.35976566
62MP0009764_decreased_sensitivity_to1.35696111
63MP0005503_abnormal_tendon_morphology1.32417882
64MP0009643_abnormal_urine_homeostasis1.32259743
65MP0005551_abnormal_eye_electrophysiolog1.32047178
66MP0003183_abnormal_peptide_metabolism1.30427504
67MP0005666_abnormal_adipose_tissue1.26655859
68MP0000516_abnormal_urinary_system1.20720529
69MP0005367_renal/urinary_system_phenotyp1.20720529
70MP0003315_abnormal_perineum_morphology1.18749106
71MP0001486_abnormal_startle_reflex1.16583104
72MP0006292_abnormal_olfactory_placode1.16495200
73MP0005220_abnormal_exocrine_pancreas1.16132369
74MP0005187_abnormal_penis_morphology1.15050505
75MP0002060_abnormal_skin_morphology1.13501005
76MP0001958_emphysema1.12804390
77* MP0005647_abnormal_sex_gland1.12781544
78MP0002557_abnormal_social/conspecific_i1.11952845
79MP0000026_abnormal_inner_ear1.11286041
80MP0004947_skin_inflammation1.09618096
81MP0002736_abnormal_nociception_after1.09158303
82MP0001968_abnormal_touch/_nociception1.08935169
83MP0001664_abnormal_digestion1.08820971
84MP0003566_abnormal_cell_adhesion1.08623171
85MP0003656_abnormal_erythrocyte_physiolo1.07921019
86MP0005085_abnormal_gallbladder_physiolo1.06503669
87MP0002136_abnormal_kidney_physiology1.06272835
88MP0003942_abnormal_urinary_system1.05001472
89MP0003045_fibrosis1.04499497
90MP0003283_abnormal_digestive_organ1.04435606
91MP0005166_decreased_susceptibility_to1.02917812
92MP0002909_abnormal_adrenal_gland1.02552448
93MP0002139_abnormal_hepatobiliary_system1.01463042
94MP0002796_impaired_skin_barrier0.99909287
95* MP0003698_abnormal_male_reproductive0.99001746
96MP0003718_maternal_effect0.96660826
97MP0001348_abnormal_lacrimal_gland0.94647594
98MP0000534_abnormal_ureter_morphology0.94048203
99MP0001764_abnormal_homeostasis0.93834595
100MP0006276_abnormal_autonomic_nervous0.93763231
101MP0002896_abnormal_bone_mineralization0.90137197
102MP0001849_ear_inflammation0.87177725
103MP0001944_abnormal_pancreas_morphology0.86879143
104MP0002733_abnormal_thermal_nociception0.86510441
105MP0000733_abnormal_muscle_development0.86329318
106MP0002876_abnormal_thyroid_physiology0.85370813
107MP0003453_abnormal_keratinocyte_physiol0.84036230
108MP0002098_abnormal_vibrissa_morphology0.83291588
109MP0003279_aneurysm0.83078863
110MP0003693_abnormal_embryo_hatching0.82444593
111MP0001905_abnormal_dopamine_level0.82148965
112MP0001440_abnormal_grooming_behavior0.81900056
113MP0001346_abnormal_lacrimal_gland0.81552966
114MP0000627_abnormal_mammary_gland0.81279703
115MP0004134_abnormal_chest_morphology0.80930981
116MP0005257_abnormal_intraocular_pressure0.78778309
117MP0000631_abnormal_neuroendocrine_gland0.78729913
118MP0000604_amyloidosis0.78044374
119MP0005076_abnormal_cell_differentiation0.77644979
120MP0009765_abnormal_xenobiotic_induced0.77576261
121MP0005395_other_phenotype0.77361762
122MP0000465_gastrointestinal_hemorrhage0.77322733
123MP0002229_neurodegeneration0.76799867
124MP0000681_abnormal_thyroid_gland0.76783590
125MP0001216_abnormal_epidermal_layer0.75823707
126MP0000470_abnormal_stomach_morphology0.74183510
127MP0002168_other_aberrant_phenotype0.73416206
128MP0000858_altered_metastatic_potential0.72944962
129MP0003937_abnormal_limbs/digits/tail_de0.71724046
130MP0005319_abnormal_enzyme/_coenzyme0.71136922
131MP0002277_abnormal_respiratory_mucosa0.70761817
132MP0002067_abnormal_sensory_capabilities0.70354992
133MP0003091_abnormal_cell_migration0.70156486
134MP0002090_abnormal_vision0.69407360
135MP0000747_muscle_weakness0.69263556
136MP0006072_abnormal_retinal_apoptosis0.68649124
137MP0000432_abnormal_head_morphology0.68095765
138* MP0003861_abnormal_nervous_system0.67905102
139MP0009250_abnormal_appendicular_skeleto0.67774316
140MP0005501_abnormal_skin_physiology0.67498146
141MP0000467_abnormal_esophagus_morphology0.67465228
142MP0002135_abnormal_kidney_morphology0.67102413
143MP0000377_abnormal_hair_follicle0.66340976
144MP0002572_abnormal_emotion/affect_behav0.65906304
145MP0002210_abnormal_sex_determination0.65311847
146MP0002116_abnormal_craniofacial_bone0.65097025
147MP0005332_abnormal_amino_acid0.64938214
148MP0002272_abnormal_nervous_system0.64895865
149MP0000343_altered_response_to0.64481969
150* MP0001145_abnormal_male_reproductive0.64123386
151MP0008875_abnormal_xenobiotic_pharmacok0.63908099
152MP0003953_abnormal_hormone_level0.63744252
153* MP0000955_abnormal_spinal_cord0.63729913
154MP0003119_abnormal_digestive_system0.63156316
155MP0004272_abnormal_basement_membrane0.63037946
156MP0002160_abnormal_reproductive_system0.61407293
157MP0001929_abnormal_gametogenesis0.61330097
158MP0000163_abnormal_cartilage_morphology0.61289099
159MP0000762_abnormal_tongue_morphology0.58513098
160MP0000230_abnormal_systemic_arterial0.57395135
161MP0001919_abnormal_reproductive_system0.55056026
162MP0002396_abnormal_hematopoietic_system0.54060585
163MP0003868_abnormal_feces_composition0.53282033
164MP0003936_abnormal_reproductive_system0.51201071
165MP0003941_abnormal_skin_development0.48859651
166MP0001533_abnormal_skeleton_physiology0.48478160

Predicted human phenotypes

RankGene SetZ-score
1Abnormality of cochlea (HP:0000375)6.03965576
2Aortic aneurysm (HP:0004942)4.99194022
3Testicular atrophy (HP:0000029)4.09562252
4Abnormality of the 2nd finger (HP:0004100)4.01527145
5Right ventricular cardiomyopathy (HP:0011663)3.95057989
6Morphological abnormality of the inner ear (HP:0011390)3.93686174
7Vacuolated lymphocytes (HP:0001922)3.91385990
8Prostate neoplasm (HP:0100787)3.73204057
9Aplasia involving bones of the upper limbs (HP:0009823)3.65900408
10Aplasia of the phalanges of the hand (HP:0009802)3.65900408
11Aplasia involving bones of the extremities (HP:0009825)3.65900408
12Dysmetric saccades (HP:0000641)3.65244249
13Amelogenesis imperfecta (HP:0000705)3.52705664
14Gonadotropin excess (HP:0000837)3.52174705
15Genetic anticipation (HP:0003743)3.47638286
16Abnormality of the distal phalanx of the thumb (HP:0009617)3.36931554
17Abnormality of the proximal phalanges of the hand (HP:0009834)3.30851811
18Exocrine pancreatic insufficiency (HP:0001738)3.28081496
19Hypoplasia of the uterus (HP:0000013)3.26854476
20Calf muscle hypertrophy (HP:0008981)3.23543911
21Atrophic scars (HP:0001075)3.23349164
22Abdominal distention (HP:0003270)3.21232202
23Aortic dissection (HP:0002647)3.08284276
24Abnormality of the phalanges of the hallux (HP:0010057)3.07646296
25Short hallux (HP:0010109)3.06433862
26Abnormal tarsal ossification (HP:0008369)3.05470696
27Abnormal foot bone ossification (HP:0010675)3.02011397
28Flattened epiphyses (HP:0003071)2.97244486
29Anal stenosis (HP:0002025)2.93409104
30Neonatal hypoglycemia (HP:0001998)2.90724063
31Abnormality of the 1st metacarpal (HP:0010009)2.89029406
32Muscle hypertrophy of the lower extremities (HP:0008968)2.88849126
33Broad face (HP:0000283)2.88745102
34Aplasia/Hypoplasia of the hallux (HP:0008362)2.85950254
35Azoospermia (HP:0000027)2.85843455
36Hypoplastic nipples (HP:0002557)2.83841943
37Mildly elevated creatine phosphokinase (HP:0008180)2.83738450
38Limb-girdle muscle atrophy (HP:0003797)2.82916083
39Aplasia/Hypoplasia of the 1st metacarpal (HP:0010026)2.79948002
40Short 1st metacarpal (HP:0010034)2.79948002
41Rectal prolapse (HP:0002035)2.78627941
42Glossoptosis (HP:0000162)2.77786092
43Fibular aplasia (HP:0002990)2.76088606
44Abnormality of the fingertips (HP:0001211)2.73440953
45Congenital stationary night blindness (HP:0007642)2.71278406
46Lip pit (HP:0100267)2.69340832
47Abnormality of the parathyroid morphology (HP:0011766)2.66880221
48Abnormality of the middle phalanges of the toes (HP:0010183)2.66145137
49Mucopolysacchariduria (HP:0008155)2.65347359
50Urinary glycosaminoglycan excretion (HP:0003541)2.65347359
51Onycholysis (HP:0001806)2.64349690
52Hyperactive renin-angiotensin system (HP:0000841)2.64198520
53Decreased circulating renin level (HP:0003351)2.64184294
54Thoracolumbar scoliosis (HP:0002944)2.64035515
55Obstructive sleep apnea (HP:0002870)2.63964042
56Protrusio acetabuli (HP:0003179)2.63234058
57Abnormality of the phalanges of the 2nd finger (HP:0009541)2.61623192
58Aplasia/Hypoplasia of the phalanges of the thumb (HP:0009658)2.60498829
59Symphalangism affecting the phalanges of the hand (HP:0009773)2.59586554
60Unilateral renal agenesis (HP:0000122)2.56542230
61Impaired smooth pursuit (HP:0007772)2.55907558
62Intracellular accumulation of autofluorescent lipopigment storage material (HP:0003204)2.54298514
63Abnormality of the intrinsic pathway (HP:0010989)2.52062508
64Ureteral stenosis (HP:0000071)2.49454852
65Ketoacidosis (HP:0001993)2.48583739
66Breast hypoplasia (HP:0003187)2.46523543
67Aplasia/Hypoplasia of the pubic bone (HP:0009104)2.45920745
68Ileus (HP:0002595)2.45662517
69Dysostosis multiplex (HP:0000943)2.45478896
70Gaze-evoked nystagmus (HP:0000640)2.44308869
71Aplasia/Hypoplasia of the middle phalanx of the 5th finger (HP:0009161)2.43336197
72Beaking of vertebral bodies (HP:0004568)2.43270315
73Depressed nasal tip (HP:0000437)2.40987636
74Urethral obstruction (HP:0000796)2.39717943
75Ureteral obstruction (HP:0006000)2.38371955
76Germ cell neoplasia (HP:0100728)2.37061795
77Aplasia/Hypoplasia of the sternum (HP:0006714)2.35175398
78Abnormality of polysaccharide metabolism (HP:0011012)2.34597209
79Abnormality of glycosaminoglycan metabolism (HP:0004371)2.34597209
80Abnormality of mucopolysaccharide metabolism (HP:0011020)2.34597209
81Bifid scrotum (HP:0000048)2.33693399
82Abnormality of chloride homeostasis (HP:0011422)2.33193517
83Aplasia/Hypoplasia of the phalanges of the toes (HP:0010173)2.31872109
84Aneurysm (HP:0002617)2.31392445
85Clumsiness (HP:0002312)2.30763493
86Abnormality of carpal bone ossification (HP:0006257)2.30607941
87Hyperparathyroidism (HP:0000843)2.29624626
88Milia (HP:0001056)2.27703424
89Hypoplasia of the pons (HP:0012110)2.25762216
90Abnormality of secondary sexual hair (HP:0009888)2.25461616
91Abnormality of the axillary hair (HP:0100134)2.25461616
92Retinal dysplasia (HP:0007973)2.25404022
93Abnormality of the aortic arch (HP:0012303)2.22453210
94Hypoplasia of the ulna (HP:0003022)2.20430666
9511 pairs of ribs (HP:0000878)2.19830055
96Rimmed vacuoles (HP:0003805)2.17463282
97Achilles tendon contracture (HP:0001771)2.17014438
98Distal arthrogryposis (HP:0005684)2.16105117
99Hand muscle atrophy (HP:0009130)2.15600103
100Myopathic facies (HP:0002058)2.14248481
101Limb ataxia (HP:0002070)2.14031504
102Aplasia/Hypoplasia of the phalanges of the 5th finger (HP:0009376)2.13226289
103Myokymia (HP:0002411)2.12895318
104Abnormal hand bone ossification (HP:0010660)2.12400828
105Biliary tract neoplasm (HP:0100574)2.11335522
106Laryngomalacia (HP:0001601)2.10145281
107Pili torti (HP:0003777)2.09298365
108Congenital sensorineural hearing impairment (HP:0008527)2.06949580
109Long toe (HP:0010511)2.05260385
110Shawl scrotum (HP:0000049)2.04843045
111Oligodontia (HP:0000677)2.03847303
112Genu varum (HP:0002970)2.02955107
113Advanced eruption of teeth (HP:0006288)2.02069835
114Protuberant abdomen (HP:0001538)2.00895042
115Aplasia/Hypoplasia involving the sinuses (HP:0009120)2.00880660
116Micronodular cirrhosis (HP:0001413)2.00575875
117Tented upper lip vermilion (HP:0010804)1.99879868
118Cervical subluxation (HP:0003308)1.99808687
119Shallow orbits (HP:0000586)1.99607031
120Microretrognathia (HP:0000308)1.99584916
121Flat acetabular roof (HP:0003180)1.99477014
122Cone-rod dystrophy (HP:0000548)1.98252664
123Abnormal ossification of hand bones (HP:0005921)1.97963768
124Subcapsular cataract (HP:0000523)1.97237002
125Abnormality of the distal phalanges of the toes (HP:0010182)1.97012924
126Pustule (HP:0200039)1.97002941
127Abnormality of the pons (HP:0007361)1.96711100
128Aplasia/hypoplasia of the femur (HP:0005613)1.96650462
129Absent phalangeal crease (HP:0006109)1.96455917
130Abnormally folded helix (HP:0008544)1.95572410
1312-3 toe syndactyly (HP:0004691)1.94697108
132Steatorrhea (HP:0002570)1.94575926
133Fat malabsorption (HP:0002630)1.94485670
134Abnormality of the ischium (HP:0003174)1.93178377
135Hyperglycinuria (HP:0003108)1.93092912
136Septate vagina (HP:0001153)1.92706473
137Abnormality of the Achilles tendon (HP:0005109)1.92592682
138Gastrointestinal dysmotility (HP:0002579)1.92086792
139Hypoplastic ischia (HP:0003175)1.91952842
140Arterial tortuosity (HP:0005116)1.91634626
141Cerebral aneurysm (HP:0004944)1.90636543
142Premature rupture of membranes (HP:0001788)1.90431520
143Ketosis (HP:0001946)1.90364339
144Coxa valga (HP:0002673)1.90364327
145Dilatation of the ascending aorta (HP:0005111)1.89934643
146Overfolded helix (HP:0000396)1.89663304
147Radial bowing (HP:0002986)1.88396938
148Ulnar deviation of finger (HP:0009465)1.88295522
149Hydroxyprolinuria (HP:0003080)1.88212190
150Abnormality of proline metabolism (HP:0010907)1.88212190
151Sparse lateral eyebrow (HP:0005338)1.87786714
152Vascular tortuosity (HP:0004948)1.87526233
153Widely patent fontanelles and sutures (HP:0004492)1.87232350
154Aplasia/hypoplasia of the uterus (HP:0008684)1.87026485
155Abnormal spermatogenesis (HP:0008669)1.86020867
156Progressive cerebellar ataxia (HP:0002073)1.85995736
157Hyperkalemia (HP:0002153)1.85904171
158Bony spicule pigmentary retinopathy (HP:0007737)1.85002483
159Polycystic kidney dysplasia (HP:0000113)1.83541753
160Patellar aplasia (HP:0006443)1.82983638
161Spinal cord compression (HP:0002176)1.82748251
162Short phalanx of the thumb (HP:0009660)1.82532372
163Hyperventilation (HP:0002883)1.81740474
164Abnormality of the vasculature of the conjunctiva (HP:0008054)1.81596121
165Abnormality of the middle phalanx of the 5th finger (HP:0004219)1.80488335
166Abnormality of ocular smooth pursuit (HP:0000617)1.80313048
167Fragile nails (HP:0001808)1.80111267
168Aplasia/Hypoplasia involving the pelvis (HP:0009103)1.79641090
169Aplasia/Hypoplasia of the patella (HP:0006498)1.78379400
170Ulnar bowing (HP:0003031)1.77585069
171Bulbar palsy (HP:0001283)1.74792867
172Short humerus (HP:0005792)1.74383473
173Aplasia/Hypoplasia involving the femoral head and neck (HP:0009108)1.74286581
174Absent hair (HP:0002298)1.72889494
175Abnormality of renin-angiotensin system (HP:0000847)1.70699129
176Abnormality of homocysteine metabolism (HP:0010919)1.70286939
177Homocystinuria (HP:0002156)1.70286939
178Hyperthyroidism (HP:0000836)1.69279345
179Impulsivity (HP:0100710)1.67188431
180Attenuation of retinal blood vessels (HP:0007843)1.65987100
181Testicular neoplasm (HP:0010788)1.65865565
182Urinary bladder sphincter dysfunction (HP:0002839)1.64187105
183Aplastic anemia (HP:0001915)1.62985508
184Aplasia involving forearm bones (HP:0009822)1.62633683

Predicted kinase interactions (KEA)

RankGene SetZ-score
1PRKD35.95303301
2CAMK1D5.53229007
3MST45.27160616
4AKT34.90898230
5FRK4.59310989
6CAMK1G4.35896271
7ERN14.08734311
8STK393.54082421
9LMTK22.99995568
10EEF2K2.91916286
11LATS12.83643427
12TAOK32.81705285
13TESK12.62050044
14SCYL22.39022921
15TESK22.37265493
16EPHA22.22753111
17MAPKAPK32.21745282
18PRKD22.15211476
19SMG12.13642059
20MYLK2.03448694
21OXSR11.99218149
22MST1R1.92687466
23MAP3K21.85640542
24BCKDK1.81446159
25WNK41.71477785
26IRAK31.67289560
27FER1.62895458
28SIK11.60419783
29LRRK21.57622717
30PIK3CA1.55999841
31PIK3CG1.53632785
32TRIB31.49346900
33LIMK11.46914498
34STK101.45680479
35PTK61.42666203
36TTN1.41627096
37INSRR1.40414926
38RPS6KB21.37704484
39MAP2K21.36676724
40GRK11.32435436
41LATS21.31841614
42MET1.21347488
43DDR21.16231874
44PDK21.11573317
45IRAK21.05413602
46NUAK11.02812022
47PRKCI0.99202605
48MARK20.99101464
49NME10.97907555
50MAPK130.97171916
51KSR20.95996821
52TAOK10.94603726
53MAP3K80.94306582
54PDGFRA0.91682385
55TAF10.86574192
56TNK20.83273659
57PNCK0.81957913
58PKN20.81498573
59WNK10.80945670
60EIF2AK10.79789068
61PAK20.79463845
62CDK70.78221439
63DMPK0.76775125
64ACVR1B0.74840920
65TRPM70.73475378
66PRKAA20.73161219
67STK30.71903883
68RIPK10.69892159
69PTK20.69785036
70STK380.69066277
71VRK20.67005233
72CDK120.66487119
73MAP2K10.65828666
74MAP3K30.65518551
75JAK30.61160567
76ROCK10.58971909
77ERBB40.56113536
78ROCK20.53093892
79DYRK30.52650032
80DAPK30.50918126
81PRKCH0.48824900
82ILK0.48685082
83PAK10.46598672
84SGK4940.45898193
85SGK2230.45898193
86CAMKK20.45459476
87PAK30.44688745
88DAPK20.44236340
89PRKG20.44142878
90PAK40.43226634
91MAP3K110.41834335
92AURKB0.40198477
93ICK0.39903991
94ERBB20.39140452
95EPHB20.38616947
96NTRK10.38282011
97RPS6KA20.37081786
98SGK20.36463026
99PTK2B0.36143261
100AURKA0.34888039
101EPHB10.34560765
102BRAF0.32190836
103MAP2K30.32070642
104STK38L0.31856607
105JAK20.31797295
106CAMKK10.31125392
107CAMK10.30831641
108PIM20.30349739
109PASK0.30024035
110BMX0.29374061
111SIK20.28569928
112CSNK1A1L0.28338774
113PRKCZ0.27529721
114ADRBK20.26089373
115MTOR0.25878580
116RET0.24370223
117NME20.23632262
118EIF2AK30.23605287
119CDK30.23602019
120BMPR1B0.23598503
121CDC42BPA0.23528208
122PRKCE0.23453563
123GSK3B0.22133092
124PHKG20.22092291
125PHKG10.22092291
126RPS6KA60.22053425
127PDK30.21674533
128PDK40.21674533
129MAP3K70.21443948
130CDK60.21307827
131MAPK150.21297686
132PRKAA10.20302797
133MELK0.20248912
134AKT10.20016219
135BRSK20.19806857
136PRKD10.19681624
137PDPK10.19608841
138CDK10.18887508
139JAK10.18478576
140MAPK80.17945197
141MATK0.16959967
142TGFBR10.16793242
143CHEK20.16778442
144CASK0.16750074
145CSNK1A10.16700182
146NEK20.16188057
147CSF1R0.16004633
148TYK20.15828175
149MAP2K40.15586537
150AKT20.15173498
151HIPK20.15149021
152SGK30.15019448
153GSK3A0.14834726
154RPS6KL10.14717164
155RPS6KC10.14717164
156RAF10.12188867
157SRC0.09977810
158PDK10.09895471
159FYN0.08472665
160ARAF0.07655025

Predicted pathways (KEGG)

RankGene SetZ-score
1Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006035.64905311
2Fatty acid biosynthesis_Homo sapiens_hsa000615.29592742
3Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006015.14269703
4Sulfur metabolism_Homo sapiens_hsa009204.88532748
5Protein processing in endoplasmic reticulum_Homo sapiens_hsa041413.65879908
6Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa005202.89726498
7Renin-angiotensin system_Homo sapiens_hsa046142.72327568
8Vibrio cholerae infection_Homo sapiens_hsa051102.41022473
9N-Glycan biosynthesis_Homo sapiens_hsa005102.38952777
10Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005332.37779382
11Protein export_Homo sapiens_hsa030602.28790626
12Vitamin digestion and absorption_Homo sapiens_hsa049772.22658067
13Mineral absorption_Homo sapiens_hsa049782.20187555
14Fatty acid metabolism_Homo sapiens_hsa012122.14062548
15Other glycan degradation_Homo sapiens_hsa005112.02591952
16Lysine degradation_Homo sapiens_hsa003101.87820504
17Cyanoamino acid metabolism_Homo sapiens_hsa004601.79864406
18Phenylalanine metabolism_Homo sapiens_hsa003601.75669026
19Bladder cancer_Homo sapiens_hsa052191.72660988
20Tryptophan metabolism_Homo sapiens_hsa003801.69142579
21Fructose and mannose metabolism_Homo sapiens_hsa000511.67407353
22Histidine metabolism_Homo sapiens_hsa003401.63290593
23Pyruvate metabolism_Homo sapiens_hsa006201.61554041
24Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005121.61548505
25Primary bile acid biosynthesis_Homo sapiens_hsa001201.57285168
26Tight junction_Homo sapiens_hsa045301.56720868
27Thyroid hormone synthesis_Homo sapiens_hsa049181.52800847
28Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005631.48934750
29alpha-Linolenic acid metabolism_Homo sapiens_hsa005921.37273826
30Synthesis and degradation of ketone bodies_Homo sapiens_hsa000721.36037254
31Adherens junction_Homo sapiens_hsa045201.35612455
32Vitamin B6 metabolism_Homo sapiens_hsa007501.35071966
33Prostate cancer_Homo sapiens_hsa052151.34747732
34Longevity regulating pathway - multiple species_Homo sapiens_hsa042131.33705747
35Butanoate metabolism_Homo sapiens_hsa006501.32460016
36Nicotine addiction_Homo sapiens_hsa050331.32299130
37Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa049601.23024431
38beta-Alanine metabolism_Homo sapiens_hsa004101.22071503
39Phototransduction_Homo sapiens_hsa047441.18795202
40Endometrial cancer_Homo sapiens_hsa052131.16355581
41Taste transduction_Homo sapiens_hsa047421.16040760
42Notch signaling pathway_Homo sapiens_hsa043301.15245552
43Protein digestion and absorption_Homo sapiens_hsa049741.14301202
44Retrograde endocannabinoid signaling_Homo sapiens_hsa047231.11760135
45Basal cell carcinoma_Homo sapiens_hsa052171.11664475
46Pathogenic Escherichia coli infection_Homo sapiens_hsa051301.08133856
47Glycine, serine and threonine metabolism_Homo sapiens_hsa002601.07035411
48Focal adhesion_Homo sapiens_hsa045101.05459653
49Amoebiasis_Homo sapiens_hsa051461.03912689
50Leukocyte transendothelial migration_Homo sapiens_hsa046701.03669308
51Taurine and hypotaurine metabolism_Homo sapiens_hsa004301.03632867
52Pentose and glucuronate interconversions_Homo sapiens_hsa000401.03034922
53Cocaine addiction_Homo sapiens_hsa050301.02119921
54Serotonergic synapse_Homo sapiens_hsa047261.00981464
55Small cell lung cancer_Homo sapiens_hsa052220.99848201
56ECM-receptor interaction_Homo sapiens_hsa045120.99174179
57Valine, leucine and isoleucine degradation_Homo sapiens_hsa002800.96753307
58Bacterial invasion of epithelial cells_Homo sapiens_hsa051000.96522616
59Glucagon signaling pathway_Homo sapiens_hsa049220.95894732
60Insulin secretion_Homo sapiens_hsa049110.94564871
61Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006040.92469643
62Citrate cycle (TCA cycle)_Homo sapiens_hsa000200.91454538
63Linoleic acid metabolism_Homo sapiens_hsa005910.85505369
64Hepatitis C_Homo sapiens_hsa051600.84129463
65Arginine and proline metabolism_Homo sapiens_hsa003300.82940776
662-Oxocarboxylic acid metabolism_Homo sapiens_hsa012100.82457899
67Cholinergic synapse_Homo sapiens_hsa047250.82444252
68Lysosome_Homo sapiens_hsa041420.82059238
69Thyroid cancer_Homo sapiens_hsa052160.80677001
70Ascorbate and aldarate metabolism_Homo sapiens_hsa000530.80608744
71Nitrogen metabolism_Homo sapiens_hsa009100.78694991
72Aldosterone synthesis and secretion_Homo sapiens_hsa049250.78514297
73Hippo signaling pathway_Homo sapiens_hsa043900.77227224
74Tyrosine metabolism_Homo sapiens_hsa003500.76191433
75Pancreatic secretion_Homo sapiens_hsa049720.74507831
76Peroxisome_Homo sapiens_hsa041460.73822667
77Propanoate metabolism_Homo sapiens_hsa006400.72559485
78Dopaminergic synapse_Homo sapiens_hsa047280.72413278
79TGF-beta signaling pathway_Homo sapiens_hsa043500.71511086
80Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa009700.70366147
81mTOR signaling pathway_Homo sapiens_hsa041500.70207342
82Morphine addiction_Homo sapiens_hsa050320.68067612
83Proteoglycans in cancer_Homo sapiens_hsa052050.67814408
84AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa049330.66767566
85Maturity onset diabetes of the young_Homo sapiens_hsa049500.66705983
86Inositol phosphate metabolism_Homo sapiens_hsa005620.66526112
87Fatty acid degradation_Homo sapiens_hsa000710.65422906
88Ovarian steroidogenesis_Homo sapiens_hsa049130.64981484
89Type II diabetes mellitus_Homo sapiens_hsa049300.64473024
90Insulin signaling pathway_Homo sapiens_hsa049100.63484965
91Glutamatergic synapse_Homo sapiens_hsa047240.63160763
92Sulfur relay system_Homo sapiens_hsa041220.62919431
93Glycerophospholipid metabolism_Homo sapiens_hsa005640.61604260
94Hedgehog signaling pathway_Homo sapiens_hsa043400.61087461
95ErbB signaling pathway_Homo sapiens_hsa040120.59454524
96Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa049610.59024035
97Pancreatic cancer_Homo sapiens_hsa052120.59011786
98Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049640.58938211
99Chronic myeloid leukemia_Homo sapiens_hsa052200.58728312
100Biosynthesis of amino acids_Homo sapiens_hsa012300.58290635
101Galactose metabolism_Homo sapiens_hsa000520.57989499
102Arginine biosynthesis_Homo sapiens_hsa002200.57858172
103Fat digestion and absorption_Homo sapiens_hsa049750.57538750
104Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa047500.56571730
105RNA polymerase_Homo sapiens_hsa030200.55906757
106GABAergic synapse_Homo sapiens_hsa047270.55710636
107Sphingolipid metabolism_Homo sapiens_hsa006000.55579988
108Renin secretion_Homo sapiens_hsa049240.55447790
109Melanoma_Homo sapiens_hsa052180.55089273
110Circadian entrainment_Homo sapiens_hsa047130.52902060
111Regulation of lipolysis in adipocytes_Homo sapiens_hsa049230.52330310
112Melanogenesis_Homo sapiens_hsa049160.51331630
113Neuroactive ligand-receptor interaction_Homo sapiens_hsa040800.51231028
114Bile secretion_Homo sapiens_hsa049760.50664449
115Ether lipid metabolism_Homo sapiens_hsa005650.50206500
116Wnt signaling pathway_Homo sapiens_hsa043100.50068761
117Insulin resistance_Homo sapiens_hsa049310.50028427
118Basal transcription factors_Homo sapiens_hsa030220.49641993
119Metabolic pathways_Homo sapiens_hsa011000.49541710
120Vascular smooth muscle contraction_Homo sapiens_hsa042700.49349241
121Olfactory transduction_Homo sapiens_hsa047400.49301818
122Amphetamine addiction_Homo sapiens_hsa050310.49132572
123HIF-1 signaling pathway_Homo sapiens_hsa040660.48089094
124Calcium signaling pathway_Homo sapiens_hsa040200.47551580
125Non-small cell lung cancer_Homo sapiens_hsa052230.45608289
126Salmonella infection_Homo sapiens_hsa051320.44403570
127Choline metabolism in cancer_Homo sapiens_hsa052310.44272645
128Glioma_Homo sapiens_hsa052140.44231346
129Pyrimidine metabolism_Homo sapiens_hsa002400.43871187
130Transcriptional misregulation in cancer_Homo sapiens_hsa052020.43718069
131Toxoplasmosis_Homo sapiens_hsa051450.42497005
132Other types of O-glycan biosynthesis_Homo sapiens_hsa005140.42119552
133Glutathione metabolism_Homo sapiens_hsa004800.41982080
134AMPK signaling pathway_Homo sapiens_hsa041520.41659404
135Influenza A_Homo sapiens_hsa051640.41296089
136Endocytosis_Homo sapiens_hsa041440.40398869
137Starch and sucrose metabolism_Homo sapiens_hsa005000.40123565
138Salivary secretion_Homo sapiens_hsa049700.39208004
139Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002500.38623784
140Gap junction_Homo sapiens_hsa045400.38314127
141Regulation of actin cytoskeleton_Homo sapiens_hsa048100.37005018
142Pathways in cancer_Homo sapiens_hsa052000.35752288
143Caffeine metabolism_Homo sapiens_hsa002320.35333439
144Cysteine and methionine metabolism_Homo sapiens_hsa002700.35094913
145Shigellosis_Homo sapiens_hsa051310.33827145
146Estrogen signaling pathway_Homo sapiens_hsa049150.32530938
147Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa051200.31019274
148Selenocompound metabolism_Homo sapiens_hsa004500.30905755
149Longevity regulating pathway - mammal_Homo sapiens_hsa042110.29655098
150Phosphatidylinositol signaling system_Homo sapiens_hsa040700.29563723
151Adipocytokine signaling pathway_Homo sapiens_hsa049200.28854726
152VEGF signaling pathway_Homo sapiens_hsa043700.28164704
153Vasopressin-regulated water reabsorption_Homo sapiens_hsa049620.27903901
154ABC transporters_Homo sapiens_hsa020100.26812467
155Arrhythmogenic right ventricular cardiomyopathy (ARVC)_Homo sapiens_hsa054120.25823867
156Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa045500.24437057
157FoxO signaling pathway_Homo sapiens_hsa040680.24386522
158Collecting duct acid secretion_Homo sapiens_hsa049660.24368786
159MicroRNAs in cancer_Homo sapiens_hsa052060.23798565
160Glycosaminoglycan degradation_Homo sapiens_hsa005310.22722943
161Prolactin signaling pathway_Homo sapiens_hsa049170.22583976
162Acute myeloid leukemia_Homo sapiens_hsa052210.22573107
163PI3K-Akt signaling pathway_Homo sapiens_hsa041510.22329417

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