HOXB3

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: This gene is a member of the Antp homeobox family and encodes a nuclear protein with a homeobox DNA-binding domain. It is included in a cluster of homeobox B genes located on chromosome 17. The encoded protein functions as a sequence-specific transcription factor that is involved in development. Increased expression of this gene is associated with a distinct biologic subset of acute myeloid leukemia (AML). NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1mesenchymal cell differentiation involved in renal system development (GO:2001012)5.36536663
2mesenchymal cell differentiation involved in kidney development (GO:0072161)5.36536663
3negative regulation of erythrocyte differentiation (GO:0045647)5.34933444
4* definitive hemopoiesis (GO:0060216)5.01662709
5mesenchymal to epithelial transition involved in metanephros morphogenesis (GO:0003337)4.66515786
6lateral sprouting from an epithelium (GO:0060601)4.62529701
7mesonephros development (GO:0001823)4.56943764
8cranial nerve structural organization (GO:0021604)4.50017263
9limb bud formation (GO:0060174)4.48689412
10facial nerve structural organization (GO:0021612)4.24925508
11* thyroid gland development (GO:0030878)4.17247514
12positive regulation of cyclin-dependent protein serine/threonine kinase activity involved in G1/S tr3.94295792
13pattern specification involved in kidney development (GO:0061004)3.94223542
14mesenchymal to epithelial transition (GO:0060231)3.92704049
15stress granule assembly (GO:0034063)3.78125073
16embryonic viscerocranium morphogenesis (GO:0048703)3.73125840
17mesenchymal cell differentiation (GO:0048762)3.72163410
18histone H3-K9 demethylation (GO:0033169)3.71101563
19neural crest cell development (GO:0014032)3.70099184
20anatomical structure arrangement (GO:0048532)3.69404764
21mesenchymal-epithelial cell signaling (GO:0060638)3.61717087
22keratinocyte development (GO:0003334)3.59357219
23kidney mesenchyme development (GO:0072074)3.56596335
24hematopoietic stem cell differentiation (GO:0060218)3.56358068
25embryonic forelimb morphogenesis (GO:0035115)3.52994111
26regulation of mesenchymal cell apoptotic process (GO:2001053)3.47713506
27peripheral nervous system neuron development (GO:0048935)3.47695013
28positive regulation of inositol phosphate biosynthetic process (GO:0060732)3.44771122
29cell differentiation involved in metanephros development (GO:0072202)3.41846693
30* embryonic organ morphogenesis (GO:0048562)3.39507204
31sympathetic nervous system development (GO:0048485)3.38645217
32forelimb morphogenesis (GO:0035136)3.37107258
33mesenchymal cell development (GO:0014031)3.36583702
34outflow tract septum morphogenesis (GO:0003148)3.32808469
35metanephric mesenchyme development (GO:0072075)3.26475424
36cell differentiation involved in kidney development (GO:0061005)3.23658149
37glomerulus development (GO:0032835)3.22455497
38head development (GO:0060322)3.14580021
39outer ear morphogenesis (GO:0042473)3.14308268
40cornea development in camera-type eye (GO:0061303)3.13047806
41eyelid development in camera-type eye (GO:0061029)3.11724367
42proximal/distal pattern formation (GO:0009954)3.11156925
43regulation of histone H3-K27 methylation (GO:0061085)3.10450470
44cell proliferation involved in kidney development (GO:0072111)3.09508363
45monoubiquitinated protein deubiquitination (GO:0035520)3.09105012
46vascular endothelial growth factor signaling pathway (GO:0038084)3.08470229
47* embryonic skeletal system morphogenesis (GO:0048704)3.08255893
48regulation of glomerulus development (GO:0090192)3.07551120
49cell-cell signaling involved in cell fate commitment (GO:0045168)3.05929609
50regulation of mammary gland epithelial cell proliferation (GO:0033599)3.04038465
51negative regulation of mesenchymal cell apoptotic process (GO:2001054)3.03942914
52developmental induction (GO:0031128)3.03677413
53regulation of cyclin-dependent protein serine/threonine kinase activity involved in G1/S transition 3.03670659
54mitotic sister chromatid cohesion (GO:0007064)3.00430319
55embryonic heart tube development (GO:0035050)2.99613814
56cell proliferation in forebrain (GO:0021846)2.98773804
57lymph vessel development (GO:0001945)2.98300715
58regulation of glucose import in response to insulin stimulus (GO:2001273)2.98263742
59metanephric epithelium development (GO:0072207)2.96825283
60negative regulation of cell size (GO:0045792)2.95427192
61central nervous system myelination (GO:0022010)2.94791168
62axon ensheathment in central nervous system (GO:0032291)2.94791168
63short-term memory (GO:0007614)2.93798657
64regulation of RNA export from nucleus (GO:0046831)2.91310858
65atrioventricular valve morphogenesis (GO:0003181)2.90789623
66cartilage development involved in endochondral bone morphogenesis (GO:0060351)2.88920309
67bone trabecula formation (GO:0060346)2.88304486
68regulation of apoptotic process involved in morphogenesis (GO:1902337)2.87882488
69metanephric tubule development (GO:0072170)2.87723888
70metanephric nephron tubule development (GO:0072234)2.87723888
71morphogenesis of an epithelial sheet (GO:0002011)2.87344145
72* cranial nerve morphogenesis (GO:0021602)2.87194525
73collagen fibril organization (GO:0030199)2.87078040
74maintenance of protein localization in endoplasmic reticulum (GO:0035437)2.86604027
75negative regulation of granulocyte differentiation (GO:0030853)2.86409106
76negative regulation of osteoblast proliferation (GO:0033689)2.85987840
77regulation of non-canonical Wnt signaling pathway (GO:2000050)2.85165664
78insulin-like growth factor receptor signaling pathway (GO:0048009)2.83978995
79stem cell development (GO:0048864)2.83956110
80regulation of mesonephros development (GO:0061217)2.83551455
81cranial nerve development (GO:0021545)2.82870079
82positive regulation of protein kinase C signaling (GO:0090037)2.82767466
83mesenchyme morphogenesis (GO:0072132)2.82734407
84semaphorin-plexin signaling pathway (GO:0071526)2.82388691
85regulation of cardioblast differentiation (GO:0051890)2.81954108
86positive regulation of blood vessel endothelial cell migration (GO:0043536)2.81251154
87neural tube development (GO:0021915)2.79036921
88protein retention in ER lumen (GO:0006621)2.78113745
89regulation of Wnt signaling pathway, planar cell polarity pathway (GO:2000095)2.77039874
90regulation of branching involved in salivary gland morphogenesis (GO:0060693)2.76444617
91retina layer formation (GO:0010842)2.76208803
92presynaptic membrane assembly (GO:0097105)2.75909124
93metanephros development (GO:0001656)2.75500671
94positive regulation of histone deacetylation (GO:0031065)2.75450909
95mesenchymal cell proliferation (GO:0010463)2.75443077
96protein heterotrimerization (GO:0070208)2.75422952
97mannose metabolic process (GO:0006013)2.75135074
98adherens junction assembly (GO:0034333)2.74837537
99planar cell polarity pathway involved in neural tube closure (GO:0090179)2.73646225
100metanephric nephron epithelium development (GO:0072243)2.73289864
101neuron remodeling (GO:0016322)2.70882510
102respiratory tube development (GO:0030323)2.70513969
103cell migration involved in heart development (GO:0060973)2.69159065
104mammary gland epithelial cell differentiation (GO:0060644)2.68002736
105positive regulation of odontogenesis (GO:0042482)2.67903690
106negative regulation of fatty acid transport (GO:2000192)2.67186530
107regulation of mitotic spindle organization (GO:0060236)2.66765147
108* anterior/posterior pattern specification (GO:0009952)2.65875483
109* skeletal system morphogenesis (GO:0048705)2.65650825
110cardiac epithelial to mesenchymal transition (GO:0060317)2.65485557
111regulation of branching involved in ureteric bud morphogenesis (GO:0090189)2.65128399
112kidney morphogenesis (GO:0060993)2.65109472
113negative regulation of axon extension involved in axon guidance (GO:0048843)2.65011197
114cochlea morphogenesis (GO:0090103)2.64897119
115glucocorticoid receptor signaling pathway (GO:0042921)2.64180467
116regulation of inositol phosphate biosynthetic process (GO:0010919)2.63933570
117mammary gland development (GO:0030879)2.62748860
118nephron epithelium development (GO:0072009)2.62274743
119regulation of cell proliferation involved in kidney development (GO:1901722)2.61928334
120regulation of nucleobase-containing compound transport (GO:0032239)2.61872817
121cartilage morphogenesis (GO:0060536)2.60950147
122vascular endothelial growth factor receptor signaling pathway (GO:0048010)2.60123565
123embryonic limb morphogenesis (GO:0030326)2.59957565
124embryonic appendage morphogenesis (GO:0035113)2.59957565
125establishment of planar polarity (GO:0001736)2.57779261
126establishment of tissue polarity (GO:0007164)2.57779261
127regulation of branching involved in prostate gland morphogenesis (GO:0060687)2.57389065
128embryonic digestive tract morphogenesis (GO:0048557)2.57339153
129UV protection (GO:0009650)2.57093404
130regulation of metanephric nephron tubule epithelial cell differentiation (GO:0072307)2.56763483
131regulation of timing of cell differentiation (GO:0048505)2.56473407
132regulation of pigment cell differentiation (GO:0050932)2.56293106
133peptidyl-lysine dimethylation (GO:0018027)2.55558172
134negative regulation of keratinocyte proliferation (GO:0010839)2.55113932
135organ growth (GO:0035265)2.54699158
136positive regulation of stem cell differentiation (GO:2000738)2.54460501
137cell proliferation involved in metanephros development (GO:0072203)2.54371060
138poly(A)+ mRNA export from nucleus (GO:0016973)2.54357377
139embryonic skeletal joint morphogenesis (GO:0060272)2.54257257
140regulation of transforming growth factor beta2 production (GO:0032909)2.54159066
141regulation of heart morphogenesis (GO:2000826)2.54090763
142regulation of establishment of planar polarity involved in neural tube closure (GO:0090178)2.53052549
143positive regulation of cardiac muscle cell differentiation (GO:2000727)2.53009639
144negative regulation of myotube differentiation (GO:0010832)2.51830599
145chondrocyte proliferation (GO:0035988)2.51455450
146negative regulation of histone methylation (GO:0031061)2.51324297
147presynaptic membrane organization (GO:0097090)2.51077910
148desmosome organization (GO:0002934)2.50220302
149smooth muscle tissue development (GO:0048745)2.50194613
150positive regulation of myotube differentiation (GO:0010831)2.49946334
151somatic stem cell division (GO:0048103)2.48991362
152sequestering of extracellular ligand from receptor (GO:0035581)2.48947592
153cellular response to vascular endothelial growth factor stimulus (GO:0035924)2.48841485
154urogenital system development (GO:0001655)2.48505349
155branch elongation of an epithelium (GO:0060602)2.48329632
156artery morphogenesis (GO:0048844)2.46572834
157epithelial to mesenchymal transition involved in endocardial cushion formation (GO:0003198)2.45657301
158mesonephric tubule development (GO:0072164)2.45621377
159extracellular regulation of signal transduction (GO:1900115)2.45489781
160histone lysine demethylation (GO:0070076)2.43764083
161collecting duct development (GO:0072044)2.43513829
162coronary vasculature morphogenesis (GO:0060977)2.42769010
163histone H3-K4 trimethylation (GO:0080182)2.42348886
164endocardial cushion development (GO:0003197)2.41458660
165regulation of monocyte differentiation (GO:0045655)2.41151660
166positive regulation of transcription from RNA polymerase II promoter in response to stress (GO:003602.40986324
167histone lysine methylation (GO:0034968)2.38273124
168positive regulation of gene expression, epigenetic (GO:0045815)2.38216508
169Wnt signaling pathway, planar cell polarity pathway (GO:0060071)2.37079697
170embryonic process involved in female pregnancy (GO:0060136)2.37006104
171nuclear pore complex assembly (GO:0051292)2.35723682
172segment specification (GO:0007379)2.35422366
173mesonephric epithelium development (GO:0072163)2.34501178
174positive regulation of protein deacetylation (GO:0090312)2.34298647
175regulation of ARF GTPase activity (GO:0032312)2.34157053
176lung secretory cell differentiation (GO:0061140)2.33804485

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1EGR1_19374776_ChIP-ChIP_THP-1_Human3.90358747
2EZH2_22144423_ChIP-Seq_EOC_Human3.50892392
3* EED_16625203_ChIP-ChIP_MESCs_Mouse3.33600875
4* JARID2_20064375_ChIP-Seq_MESCs_Mouse3.13364738
5* EZH2_27304074_Chip-Seq_ESCs_Mouse3.11833015
6GBX2_23144817_ChIP-Seq_PC3_Human2.99662869
7* ELK3_25401928_ChIP-Seq_HUVEC_Human2.99653062
8RARG_19884340_ChIP-ChIP_MEFs_Mouse2.98133154
9* SUZ12_16625203_ChIP-ChIP_MESCs_Mouse2.88306142
10* SUZ12_18692474_ChIP-Seq_MEFs_Mouse2.81030951
11* BMI1_23680149_ChIP-Seq_NPCS_Mouse2.80245304
12* CBX2_27304074_Chip-Seq_ESCs_Mouse2.78280466
13* EZH2_18974828_ChIP-Seq_MESCs_Mouse2.76677818
14* RNF2_18974828_ChIP-Seq_MESCs_Mouse2.76677818
15* SUZ12_18692474_ChIP-Seq_MESCs_Mouse2.74091780
16* SUZ12_18555785_ChIP-Seq_MESCs_Mouse2.67732658
17KDM2B_26808549_Chip-Seq_SIL-ALL_Human2.67144945
18* JARID2_20075857_ChIP-Seq_MESCs_Mouse2.66854420
19* SUZ12_18974828_ChIP-Seq_MESCs_Mouse2.61622309
20* PHC1_16625203_ChIP-ChIP_MESCs_Mouse2.59502841
21NUCKS1_24931609_ChIP-Seq_HEPATOCYTES_Mouse2.48329108
22KDM2B_26808549_Chip-Seq_SUP-B15_Human2.46434310
23* EZH2_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse2.43546271
24TP63_17297297_ChIP-ChIP_HaCaT_Human2.42641731
25VDR_21846776_ChIP-Seq_THP-1_Human2.39272350
26* RNF2_16625203_ChIP-ChIP_MESCs_Mouse2.37327557
27TCF7_22412390_ChIP-Seq_EML_Mouse2.28379810
28MYC_22102868_ChIP-Seq_BL_Human2.25783955
29CDX2_19796622_ChIP-Seq_MESCs_Mouse2.23278125
30* EZH2_27294783_Chip-Seq_ESCs_Mouse2.22297695
31E2F7_22180533_ChIP-Seq_HELA_Human2.20795015
32KDM2B_26808549_Chip-Seq_DND41_Human2.18689897
33* RNF2_27304074_Chip-Seq_ESCs_Mouse2.15001812
34WT1_20215353_ChIP-ChIP_NEPHRON_PROGENITOR_Mouse2.14625690
35* SUZ12_27294783_Chip-Seq_ESCs_Mouse2.13683117
36TBP_23326641_ChIP-Seq_C3H10T1-2_Mouse2.11193247
37LXR_22292898_ChIP-Seq_THP-1_Human2.06663653
38KDM2B_26808549_Chip-Seq_K562_Human2.06511210
39THRA_23701648_ChIP-Seq_CEREBELLUM_Mouse1.97954234
40RACK7_27058665_Chip-Seq_MCF-7_Human1.97785221
41* MTF2_20144788_ChIP-Seq_MESCs_Mouse1.97674191
42CIITA_18437201_ChIP-ChIP_Raji_B_and_iDC_Human1.92839669
43KLF6_26769127_Chip-Seq_PDAC-Cell_line_Human1.92194354
44GLI1_17442700_ChIP-ChIP_MESCs_Mouse1.90363633
45TP63_19390658_ChIP-ChIP_HaCaT_Human1.89813839
46ZFP57_27257070_Chip-Seq_ESCs_Mouse1.89241055
47* POU5F1_16153702_ChIP-ChIP_HESCs_Human1.88534764
48TAF15_26573619_Chip-Seq_HEK293_Human1.88361671
49KDM2B_26808549_Chip-Seq_JURKAT_Human1.88292243
50CLOCK_20551151_ChIP-Seq_293T_Human1.86498977
51KLF4_26769127_Chip-Seq_PDAC-Cell_line_Human1.85728103
52RUNX2_24764292_ChIP-Seq_MC3T3_Mouse1.85481316
53AR_21572438_ChIP-Seq_LNCaP_Human1.83534063
54HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse1.82698047
55* RNF2_27304074_Chip-Seq_NSC_Mouse1.82422699
56KDM2B_26808549_Chip-Seq_HPB-ALL_Human1.80303523
57VDR_22108803_ChIP-Seq_LS180_Human1.78806568
58WT1_19549856_ChIP-ChIP_CCG9911_Human1.77152207
59P300_27058665_Chip-Seq_ZR-75-30cells_Human1.75778538
60CEBPD_23245923_ChIP-Seq_MEFs_Mouse1.74126807
61* SUZ12_20075857_ChIP-Seq_MESCs_Mouse1.73598122
62BP1_19119308_ChIP-ChIP_Hs578T_Human1.71820773
63PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human1.71275182
64* ZFP281_27345836_Chip-Seq_ESCs_Mouse1.70544166
65* TP53_20018659_ChIP-ChIP_R1E_Mouse1.70501895
66IKZF1_21737484_ChIP-ChIP_HCT116_Human1.67451045
67TFAP2C_20629094_ChIP-Seq_MCF-7_Human1.65549714
68PIAS1_25552417_ChIP-Seq_VCAP_Human1.62726163
69DMRT1_23473982_ChIP-Seq_TESTES_Mouse1.61498577
70VDR_24763502_ChIP-Seq_THP-1_Human1.60101106
71P300_19829295_ChIP-Seq_ESCs_Human1.59827824
72STAT6_21828071_ChIP-Seq_BEAS2B_Human1.58800865
73UBF1/2_26484160_Chip-Seq_HMECs_Human1.58630812
74* NFIB_24661679_ChIP-Seq_LUNG_Mouse1.58523267
75TRIM28_21343339_ChIP-Seq_HEK293_Human1.57290278
76NCOR1_26117541_ChIP-Seq_K562_Human1.54226511
77CEBPB_21427703_ChIP-Seq_3T3-L1_Mouse1.51873570
78TP53_18474530_ChIP-ChIP_U2OS_Human1.49811932
79RUNX1_27514584_Chip-Seq_MCF-7_Human1.49443106
80CREB1_26743006_Chip-Seq_LNCaP_Human1.48791062
81* EGR1_20690147_ChIP-Seq_ERYTHROLEUKEMIA_Human1.48329945
82CTCF_27219007_Chip-Seq_ERYTHROID_Human1.48279945
83* RING1B_27294783_Chip-Seq_NPCs_Mouse1.48230111
84UBF1/2_26484160_Chip-Seq_HMEC-DERIVED_Human1.47258706
85SOX9_22984422_ChIP-ChIP_TESTIS_Rat1.42308989
86* RING1B_27294783_Chip-Seq_ESCs_Mouse1.41986099
87FUS_26573619_Chip-Seq_HEK293_Human1.40818554
88CHD7_19251738_ChIP-ChIP_MESCs_Mouse1.40809033
89CTBP2_25329375_ChIP-Seq_LNCAP_Human1.40527839
90SMAD3_21741376_ChIP-Seq_EPCs_Human1.40155814
91CTBP1_25329375_ChIP-Seq_LNCAP_Human1.38284792
92CREB1_26743006_Chip-Seq_LNCaP-abl_Human1.37643919
93SMAD_19615063_ChIP-ChIP_OVARY_Human1.36303772
94TCF21_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human1.33521755
95GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.32839789
96FOXM1_23109430_ChIP-Seq_U2OS_Human1.31692149
97ELF3_26769127_Chip-Seq_PDAC-Cell_line_Human1.30809273
98CTNNB1_20615089_ChIP-ChIP_FETAL_BRAIN_Human1.30424279
99ZNF217_24962896_ChIP-Seq_MCF-7_Human1.29438286
100POU3F2_20337985_ChIP-ChIP_501MEL_Human1.26900714
101SCL_19346495_ChIP-Seq_HPC-7_Human1.26288674
102CDX2_20551321_ChIP-Seq_CACO-2_Human1.25744432
103SA1_27219007_Chip-Seq_ERYTHROID_Human1.25640671
104ZNF263_19887448_ChIP-Seq_K562_Human1.25307142
105PCGF2_27294783_Chip-Seq_ESCs_Mouse1.23748720
106TCF3_18467660_ChIP-ChIP_MESCs_Mouse1.23401899
107TOP2B_26459242_ChIP-Seq_MCF-7_Human1.21969008
108UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human1.21444740
109SMAD2/3_21741376_ChIP-Seq_EPCs_Human1.20860715
110PCGF2_27294783_Chip-Seq_NPCs_Mouse1.20327483
111SMAD4_21799915_ChIP-Seq_A2780_Human1.19079948
112* ESR1_20079471_ChIP-ChIP_T-47D_Human1.18588007
113CEBPB_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.17726909
114ARNT_22903824_ChIP-Seq_MCF-7_Human1.17043912
115GATA1_19941826_ChIP-Seq_K562_Human1.16911504
116IGF1R_20145208_ChIP-Seq_DFB_Human1.15793440
117TET1_21451524_ChIP-Seq_MESCs_Mouse1.14895333
118OLIG2_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.13986793
119* ZFP281_18757296_ChIP-ChIP_E14_Mouse1.13776573
120ZFP281_18358816_ChIP-ChIP_MESCs_Mouse1.12623022
121PPARG_19300518_ChIP-PET_3T3-L1_Mouse1.12532976
122ESR1_22446102_ChIP-Seq_UTERUS_Mouse1.12507772
123TP53_22127205_ChIP-Seq_IMR90_Human1.12472662
124TCFCP2L1_18555785_Chip-Seq_ESCs_Mouse1.11689933
125FOXM1_26100407_CHIP-SEQ_Hek293_flp-in_Human1.11674364
126EWS_26573619_Chip-Seq_HEK293_Human1.10573760
127MYCN_27167114_Chip-Seq_NEUROBLASTOMA_Human1.10119270
128EBF1_22473956_ChIP-Seq_BONE_MARROW_Mouse1.09329205
129STAT3_19079543_ChIP-ChIP_MESCs_Mouse1.07919489
130TAF7L_23326641_ChIP-Seq_C3H10T1-2_Mouse1.07581119
131NANOG_18555785_Chip-Seq_ESCs_Mouse1.07411438
132* SMAD3_22036565_ChIP-Seq_ESCs_Mouse1.07329554
133ESR2_21235772_ChIP-Seq_MCF-7_Human1.07160103
134AHR_22903824_ChIP-Seq_MCF-7_Human1.06642379
135CEBPB_26923725_Chip-Seq_MESODERM_Mouse1.06489576
136TAL1_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.05943878
137AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human1.05906727
138TRP63_18441228_ChIP-ChIP_KERATINOCYTES_Mouse1.05754495
139SUZ12_27294783_Chip-Seq_NPCs_Mouse1.05696859
140DROSHA_22980978_ChIP-Seq_HELA_Human1.04949783
141FLI1_27457419_Chip-Seq_LIVER_Mouse1.04753951
142POU5F1_26923725_Chip-Seq_MESODERM_Mouse1.04093310
143TEAD4_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.04093310
144PRDM16_22522345_ChIP-ChIP_PALATE_MESENCHYMAL_Mouse1.03956565
145ZNF652_21678463_ChIP-ChIP_ZR75-1_Human1.03735134
146TRIM28_17542650_ChIP-ChIP_NTERA2_Human1.02556339
147EP300_21415370_ChIP-Seq_HL-1_Mouse1.02249040
148SMC4_20622854_ChIP-Seq_HELA_Human1.02093964
149P68_20966046_ChIP-Seq_HELA_Human1.02087311
150SOX2_27498859_Chip-Seq_STOMACH_Mouse1.02083719
151PPARD_23176727_ChIP-Seq_KERATINOCYTES_Mouse1.00986379
152TP53_16413492_ChIP-PET_HCT116_Human1.00932702
153TCFAP2C_20176728_ChIP-ChIP_TROPHOBLAST_STEM_CELLS_Mouse1.00089396
154CTCF_27219007_Chip-Seq_Bcells_Human0.99976518
155CEBPD_21427703_ChIP-Seq_3T3-L1_Mouse0.99315690
156E2F1_18555785_Chip-Seq_ESCs_Mouse0.99142206
157ER_23166858_ChIP-Seq_MCF-7_Human0.99003003
158SMAD2_18955504_ChIP-ChIP_HaCaT_Human0.98958457
159SMAD3_18955504_ChIP-ChIP_HaCaT_Human0.98958457
160TBX20_22080862_ChIP-Seq_HEART_Mouse0.98374150
161TBX20_22328084_ChIP-Seq_HEART_Mouse0.98374150
162MAF_26560356_Chip-Seq_TH2_Human0.98311233
163ISL1_27105846_Chip-Seq_CPCs_Mouse0.98095644
164KLF5_18264089_ChIP-ChIP_MESCs_Mouse0.97858161
165KLF4_18264089_ChIP-ChIP_MESCs_Mouse0.97858161
166KLF2_18264089_ChIP-ChIP_MESCs_Mouse0.97858161
167CREB1_23762244_ChIP-Seq_HIPPOCAMPUS_Rat0.97841196
168ATF3_27146783_Chip-Seq_COLON_Human0.97157422
169* SOX9_24532713_ChIP-Seq_HFSC_Mouse0.96672250
170CREB1_20920259_ChIP-Seq_GC1-SPG_Mouse0.96263238
171SMARCA4_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse0.95356059
172SMAD3_21741376_ChIP-Seq_HESCs_Human0.95297531
173RUNX2_22187159_ChIP-Seq_PCA_Human0.94930133
174EP300_20729851_ChIP-Seq_FORBRAIN_MIDBRAIN_LIMB_HEART_Mouse0.94118297
175LMO2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse0.94027235
176P53_22387025_ChIP-Seq_ESCs_Mouse0.93788736
177SUZ12_18555785_Chip-Seq_ESCs_Mouse0.92919489

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0000566_synostosis3.72169624
2MP0005670_abnormal_white_adipose3.27657539
3MP0002102_abnormal_ear_morphology3.14978401
4MP0003705_abnormal_hypodermis_morpholog3.01387140
5MP0003136_yellow_coat_color2.94038640
6* MP0002249_abnormal_larynx_morphology2.90191468
7MP0003279_aneurysm2.83251731
8MP0009250_abnormal_appendicular_skeleto2.82416741
9MP0003941_abnormal_skin_development2.77859912
10MP0003385_abnormal_body_wall2.76179848
11MP0000049_abnormal_middle_ear2.49422112
12MP0004381_abnormal_hair_follicle2.44690040
13MP0005623_abnormal_meninges_morphology2.37000995
14MP0010030_abnormal_orbit_morphology2.36811950
15MP0003938_abnormal_ear_development2.33379885
16MP0000733_abnormal_muscle_development2.33187251
17MP0005503_abnormal_tendon_morphology2.24938730
18MP0006292_abnormal_olfactory_placode2.21074337
19MP0005409_darkened_coat_color2.17669081
20MP0002938_white_spotting2.10978485
21MP0005666_abnormal_adipose_tissue2.04688660
22MP0002396_abnormal_hematopoietic_system2.04019863
23MP0003942_abnormal_urinary_system1.98650603
24MP0000762_abnormal_tongue_morphology1.97272268
25MP0009379_abnormal_foot_pigmentation1.91341998
26MP0003880_abnormal_central_pattern1.90464370
27MP0003937_abnormal_limbs/digits/tail_de1.88367883
28MP0003315_abnormal_perineum_morphology1.87169475
29MP0002282_abnormal_trachea_morphology1.80101419
30MP0005076_abnormal_cell_differentiation1.79366160
31MP0003122_maternal_imprinting1.78551556
32MP0001188_hyperpigmentation1.77030453
33MP0005375_adipose_tissue_phenotype1.75914665
34MP0004272_abnormal_basement_membrane1.73349762
35MP0000516_abnormal_urinary_system1.69693140
36MP0005367_renal/urinary_system_phenotyp1.69693140
37MP0004808_abnormal_hematopoietic_stem1.68760226
38MP0009384_cardiac_valve_regurgitation1.65304124
39MP0000383_abnormal_hair_follicle1.63816852
40MP0005275_abnormal_skin_tensile1.63549430
41MP0001879_abnormal_lymphatic_vessel1.62556058
42MP0001849_ear_inflammation1.61010974
43MP0004084_abnormal_cardiac_muscle1.58662951
44MP0000534_abnormal_ureter_morphology1.56952339
45MP0002877_abnormal_melanocyte_morpholog1.56391769
46MP0000003_abnormal_adipose_tissue1.56005571
47MP0000767_abnormal_smooth_muscle1.55340807
48MP0002098_abnormal_vibrissa_morphology1.55300533
49MP0004185_abnormal_adipocyte_glucose1.55106701
50MP0002177_abnormal_outer_ear1.53973679
51MP0004742_abnormal_vestibular_system1.52018436
52MP0002233_abnormal_nose_morphology1.48068376
53MP0009278_abnormal_bone_marrow1.46089272
54MP0004782_abnormal_surfactant_physiolog1.45505684
55MP0005508_abnormal_skeleton_morphology1.43018980
56MP0005451_abnormal_body_composition1.42790095
57MP0010368_abnormal_lymphatic_system1.41871602
58* MP0000681_abnormal_thyroid_gland1.41706527
59MP0000013_abnormal_adipose_tissue1.38035801
60MP0005171_absent_coat_pigmentation1.37645312
61MP0003755_abnormal_palate_morphology1.36823162
62MP0001348_abnormal_lacrimal_gland1.35100169
63MP0003115_abnormal_respiratory_system1.33644770
64MP0000759_abnormal_skeletal_muscle1.32191170
65MP0001346_abnormal_lacrimal_gland1.31780854
66MP0000678_abnormal_parathyroid_gland1.31660489
67MP0000537_abnormal_urethra_morphology1.30564032
68MP0000026_abnormal_inner_ear1.29975277
69MP0006138_congestive_heart_failure1.29905478
70MP0002277_abnormal_respiratory_mucosa1.26504440
71MP0000778_abnormal_nervous_system1.25865538
72MP0001340_abnormal_eyelid_morphology1.24782703
73MP0008438_abnormal_cutaneous_collagen1.23970110
74* MP0002116_abnormal_craniofacial_bone1.21276105
75MP0002925_abnormal_cardiovascular_devel1.21263513
76MP0003091_abnormal_cell_migration1.20279985
77MP0000462_abnormal_digestive_system1.20159105
78MP0001486_abnormal_startle_reflex1.19534078
79MP0004134_abnormal_chest_morphology1.18059683
80MP0000432_abnormal_head_morphology1.17913947
81* MP0002932_abnormal_joint_morphology1.16679487
82MP0000631_abnormal_neuroendocrine_gland1.13284983
83MP0003566_abnormal_cell_adhesion1.13027238
84MP0003045_fibrosis1.12577091
85MP0008007_abnormal_cellular_replicative1.12386027
86MP0002796_impaired_skin_barrier1.11607554
87MP0000467_abnormal_esophagus_morphology1.11065997
88MP0002109_abnormal_limb_morphology1.10806434
89MP0005248_abnormal_Harderian_gland1.09514432
90MP0010678_abnormal_skin_adnexa1.09314292
91MP0005257_abnormal_intraocular_pressure1.09248660
92* MP0002114_abnormal_axial_skeleton1.07977645
93MP0000647_abnormal_sebaceous_gland1.06424515
94MP0010630_abnormal_cardiac_muscle1.04466684
95MP0009115_abnormal_fat_cell1.03106718
96MP0000751_myopathy1.02901897
97MP0003935_abnormal_craniofacial_develop1.02205817
98MP0001270_distended_abdomen1.02007067
99* MP0000163_abnormal_cartilage_morphology1.01933909
100MP0002751_abnormal_autonomic_nervous1.00394892
101MP0008961_abnormal_basal_metabolism1.00332951
102MP0000579_abnormal_nail_morphology0.99562935
103MP0004036_abnormal_muscle_relaxation0.99302039
104MP0001614_abnormal_blood_vessel0.98384996
105MP0002896_abnormal_bone_mineralization0.97488271
106MP0000538_abnormal_urinary_bladder0.96635067
107MP0003959_abnormal_lean_body0.96586322
108MP0003121_genomic_imprinting0.93698784
109MP0008057_abnormal_DNA_replication0.93573727
110MP0002127_abnormal_cardiovascular_syste0.93433932
111MP0001286_abnormal_eye_development0.93121644
112MP0010352_gastrointestinal_tract_polyps0.92320087
113MP0003943_abnormal_hepatobiliary_system0.91515912
114MP0003828_pulmonary_edema0.90461374
115MP0003172_abnormal_lysosome_physiology0.89027549
116MP0002971_abnormal_brown_adipose0.88429051
117MP0002115_abnormal_skeleton_extremities0.88282353
118MP0000266_abnormal_heart_morphology0.87075350
119MP0002108_abnormal_muscle_morphology0.86839170
120MP0000428_abnormal_craniofacial_morphol0.86639843
121MP0001664_abnormal_digestion0.86540154
122MP0000613_abnormal_salivary_gland0.85971681
123MP0009053_abnormal_anal_canal0.85666592
124MP0002060_abnormal_skin_morphology0.84879643
125MP0005595_abnormal_vascular_smooth0.84147070
126MP0010771_integument_phenotype0.83892519
127MP0001299_abnormal_eye_distance/0.83487416
128MP0005390_skeleton_phenotype0.83091755
129MP0002086_abnormal_extraembryonic_tissu0.82874520
130MP0002970_abnormal_white_adipose0.82713391
131* MP0002752_abnormal_somatic_nervous0.82429581
132MP0008995_early_reproductive_senescence0.82329412
133* MP0002085_abnormal_embryonic_tissue0.82319119
134MP0003984_embryonic_growth_retardation0.79772266
135MP0000350_abnormal_cell_proliferation0.79468948
136MP0001958_emphysema0.79344431
137MP0001968_abnormal_touch/_nociception0.78931785
138MP0002557_abnormal_social/conspecific_i0.78773542
139MP0005397_hematopoietic_system_phenotyp0.78591419
140MP0001545_abnormal_hematopoietic_system0.78591419
141MP0003948_abnormal_gas_homeostasis0.78520368
142MP0004264_abnormal_extraembryonic_tissu0.78094637
143MP0002697_abnormal_eye_size0.77980766
144MP0002113_abnormal_skeleton_development0.77748038
145MP0004858_abnormal_nervous_system0.77370570
146MP0001501_abnormal_sleep_pattern0.76842579
147MP0002128_abnormal_blood_circulation0.76599399
148MP0001963_abnormal_hearing_physiology0.75967194
149MP0003787_abnormal_imprinting0.74935250
150MP0001730_embryonic_growth_arrest0.74803376
151MP0005058_abnormal_lysosome_morphology0.74092732
152MP0003011_delayed_dark_adaptation0.73841888
153MP0004087_abnormal_muscle_fiber0.73796612
154MP0004883_abnormal_blood_vessel0.71467175
155MP0005501_abnormal_skin_physiology0.71240853
156MP0002184_abnormal_innervation0.71154571
157MP0001727_abnormal_embryo_implantation0.71131140
158MP0002067_abnormal_sensory_capabilities0.70376830
159MP0006276_abnormal_autonomic_nervous0.70358858
160MP0003950_abnormal_plasma_membrane0.70318470
161MP0003936_abnormal_reproductive_system0.69591083
162MP0002009_preneoplasia0.69380850
163MP0002132_abnormal_respiratory_system0.67947036

Predicted human phenotypes

RankGene SetZ-score
1Aplasia cutis congenita (HP:0001057)4.77678461
2Protrusio acetabuli (HP:0003179)3.85192612
3Absent/shortened dynein arms (HP:0200106)3.84615316
4Dynein arm defect of respiratory motile cilia (HP:0012255)3.84615316
5Premature rupture of membranes (HP:0001788)3.72351112
6Morphological abnormality of the middle ear (HP:0008609)3.70623792
7Obstructive sleep apnea (HP:0002870)3.65050579
8Nasolacrimal duct obstruction (HP:0000579)3.51670148
9Abnormality of the nasolacrimal system (HP:0000614)3.50873397
10Abnormality of the parietal bone (HP:0002696)3.45186566
11Broad face (HP:0000283)3.44033261
12Abnormality of the lacrimal duct (HP:0011481)3.43788667
13Partial duplication of the phalanx of hand (HP:0009999)3.32111355
14Cerebral aneurysm (HP:0004944)3.29923762
15Cervical subluxation (HP:0003308)3.28281964
16Midline defect of the nose (HP:0004122)3.25795327
17Partial duplication of thumb phalanx (HP:0009944)3.24553176
18Aortic aneurysm (HP:0004942)3.07761008
19Parakeratosis (HP:0001036)3.06886341
20Abnormality of secondary sexual hair (HP:0009888)3.04918295
21Abnormality of the axillary hair (HP:0100134)3.04918295
22Duplication of thumb phalanx (HP:0009942)2.93464850
23White forelock (HP:0002211)2.93300699
24Aortic dissection (HP:0002647)2.91917672
25Abnormality of the nasal septum (HP:0000419)2.89788955
26Anophthalmia (HP:0000528)2.89701143
27Abnormal ciliary motility (HP:0012262)2.88197188
28Abnormality of the fingertips (HP:0001211)2.87888572
29Septo-optic dysplasia (HP:0100842)2.84036859
30Bell-shaped thorax (HP:0001591)2.78880579
31Fragile skin (HP:0001030)2.78222203
32Patchy hypopigmentation of hair (HP:0011365)2.73901819
33Bladder diverticulum (HP:0000015)2.73067928
34Abnormality of the pulmonary veins (HP:0011718)2.59617993
35Hypoplasia of the iris (HP:0007676)2.59299577
36Abnormal respiratory motile cilium morphology (HP:0005938)2.58135266
37Abnormal respiratory epithelium morphology (HP:0012253)2.58135266
38Ankyloglossia (HP:0010296)2.57981717
39Hyperacusis (HP:0010780)2.57080716
40Long eyelashes (HP:0000527)2.56123005
41Spinal rigidity (HP:0003306)2.56030430
42Concave nail (HP:0001598)2.53172964
43Vascular tortuosity (HP:0004948)2.52041471
44Abnormality of the phalanges of the 2nd finger (HP:0009541)2.51811938
45Arterial tortuosity (HP:0005116)2.50268563
46Lip pit (HP:0100267)2.47079139
47Spondylolisthesis (HP:0003302)2.45277523
48Metabolic alkalosis (HP:0200114)2.41219403
49Anomalous pulmonary venous return (HP:0010772)2.38478177
50Conical tooth (HP:0000698)2.37969116
51Increased variability in muscle fiber diameter (HP:0003557)2.37557979
52Supernumerary spleens (HP:0009799)2.37528251
53Aortic regurgitation (HP:0001659)2.36673452
54Reticulocytopenia (HP:0001896)2.35107788
55Natal tooth (HP:0000695)2.34578504
56Mildly elevated creatine phosphokinase (HP:0008180)2.33890838
57Mitral valve prolapse (HP:0001634)2.32146945
58Aneurysm (HP:0002617)2.28378909
59Recurrent corneal erosions (HP:0000495)2.27254557
60Hypoplastic left heart (HP:0004383)2.24046746
61Periauricular skin pits (HP:0100277)2.23427160
62Preauricular pit (HP:0004467)2.23427160
63Disproportionate tall stature (HP:0001519)2.23015404
64Biconcave vertebral bodies (HP:0004586)2.22484455
65Renal dysplasia (HP:0000110)2.21819077
66Supernumerary ribs (HP:0005815)2.21430880
67Soft skin (HP:0000977)2.20605072
68Acute lymphatic leukemia (HP:0006721)2.20287099
69Asymmetry of the thorax (HP:0001555)2.19763650
70Respiratory insufficiency due to defective ciliary clearance (HP:0200073)2.18899028
71Wormian bones (HP:0002645)2.18230355
72Dilatation of the ascending aorta (HP:0005111)2.17064227
73Shallow orbits (HP:0000586)2.16593865
74Atelectasis (HP:0100750)2.16049259
75Overfolded helix (HP:0000396)2.15442578
76Chin dimple (HP:0010751)2.14745227
77Sex reversal (HP:0012245)2.14742349
78Abnormal sex determination (HP:0012244)2.14742349
79Overgrowth (HP:0001548)2.14512751
80Abnormal respiratory motile cilium physiology (HP:0012261)2.13132171
81Short clavicles (HP:0000894)2.13127468
82Abnormality of the 2nd finger (HP:0004100)2.12528524
83Joint laxity (HP:0001388)2.12139891
84Abnormality of incisor morphology (HP:0011063)2.11802292
85Renal agenesis (HP:0000104)2.11121438
86Narrow palate (HP:0000189)2.09230426
87Genetic anticipation (HP:0003743)2.09000037
88Acute myeloid leukemia (HP:0004808)2.07567852
89J-shaped sella turcica (HP:0002680)2.07511188
90Metaphyseal cupping (HP:0003021)2.06974476
91Atrophic scars (HP:0001075)2.06510451
92Abnormality of the aortic arch (HP:0012303)2.04370500
93Abnormality of oral frenula (HP:0000190)2.03635121
94Aplasia involving bones of the extremities (HP:0009825)2.03320825
95Aplasia involving bones of the upper limbs (HP:0009823)2.03320825
96Aplasia of the phalanges of the hand (HP:0009802)2.03320825
97Neonatal short-limb short stature (HP:0008921)2.03278748
98Humeroradial synostosis (HP:0003041)2.03065561
99Synostosis involving the elbow (HP:0003938)2.03065561
100Hypomagnesemia (HP:0002917)2.02349279
101Cutaneous finger syndactyly (HP:0010554)2.01138060
102Absent septum pellucidum (HP:0001331)2.00964057
103Mitral regurgitation (HP:0001653)2.00793698
104Type 1 muscle fiber predominance (HP:0003803)2.00467241
105Ulnar claw (HP:0001178)1.98850134
106Alacrima (HP:0000522)1.98600870
107Genu recurvatum (HP:0002816)1.97863571
108Short middle phalanx of the 5th finger (HP:0004220)1.97737052
109Blue sclerae (HP:0000592)1.97640216
110Coronal craniosynostosis (HP:0004440)1.97461097
111Thin bony cortex (HP:0002753)1.97134651
112Hypotrichosis (HP:0001006)1.96675840
113Bowel diverticulosis (HP:0005222)1.96419808
114Abnormality of skeletal muscle fiber size (HP:0012084)1.95430161
115Abnormality of the distal phalanx of the thumb (HP:0009617)1.95425006
116Cone-shaped epiphyses of the phalanges of the hand (HP:0010230)1.93984061
117Urethral obstruction (HP:0000796)1.93248154
118Supernumerary bones of the axial skeleton (HP:0009144)1.93073216
119Persistence of primary teeth (HP:0006335)1.92277749
120Duplicated collecting system (HP:0000081)1.91673748
121Preaxial foot polydactyly (HP:0001841)1.91651765
122Follicular hyperkeratosis (HP:0007502)1.91436717
123Aplasia/Hypoplasia of the clavicles (HP:0006710)1.91014167
124Abnormality of the renal medulla (HP:0100957)1.90860193
125Xerostomia (HP:0000217)1.90050690
126Macroorchidism (HP:0000053)1.90027412
127Broad metatarsal (HP:0001783)1.88891296
128Increased circulating renin level (HP:0000848)1.88509387
129Abnormality of the fetal cardiovascular system (HP:0010948)1.88486300
130Abnormal umbilical cord blood vessels (HP:0011403)1.88486300
131Single umbilical artery (HP:0001195)1.88486300
132Flat acetabular roof (HP:0003180)1.88405049
133Abnormality of the anterior chamber (HP:0000593)1.87757754
134Abnormality of the antihelix (HP:0009738)1.86882271
135Congenital nonbullous ichthyosiform erythroderma (HP:0007479)1.86492622
136Ankle contracture (HP:0006466)1.85216225
137Abnormality of the ischium (HP:0003174)1.85103708
138Dislocated radial head (HP:0003083)1.84586381
139Hypoplastic ischia (HP:0003175)1.84390452
140Down-sloping shoulders (HP:0200021)1.84308122
141Abnormality of the renal collecting system (HP:0004742)1.82440630
142Pulmonary artery stenosis (HP:0004415)1.82422781
143Abnormality of the septum pellucidum (HP:0007375)1.82143944
144Venous abnormality (HP:0002624)1.81963664
145Ulnar bowing (HP:0003031)1.81830748
146Hypoplastic heart (HP:0001961)1.81718043
147Fibular hypoplasia (HP:0003038)1.81332798
148Bifid scrotum (HP:0000048)1.80649248
149Dysmetric saccades (HP:0000641)1.80445976
150Abnormally folded helix (HP:0008544)1.80212298
151Spinal cord lesions (HP:0100561)1.77142408
152Syringomyelia (HP:0003396)1.77142408
153Thin ribs (HP:0000883)1.76629627
154Increased corneal curvature (HP:0100692)1.76450659
155Keratoconus (HP:0000563)1.76450659
156Mixed hearing impairment (HP:0000410)1.75423113
157Truncal obesity (HP:0001956)1.75258901
158Patellar dislocation (HP:0002999)1.74993792
159Abnormality of the radial head (HP:0003995)1.74845177
160Abnormality of the acetabulum (HP:0003170)1.74653877
161Ectopia lentis (HP:0001083)1.73837983
162Venous insufficiency (HP:0005293)1.72908867
163Abnormality of renin-angiotensin system (HP:0000847)1.72868895
164Renal hypoplasia (HP:0000089)1.71950286
165Abnormality of the calcaneus (HP:0008364)1.71766770
166Deformed sella turcica (HP:0002681)1.71650130
167Myelomeningocele (HP:0002475)1.71081336
168Distal lower limb amyotrophy (HP:0008944)1.70624312
169Short 5th finger (HP:0009237)1.70558204
170Cutaneous syndactyly (HP:0012725)1.70231735
171Stage 5 chronic kidney disease (HP:0003774)1.69855183
172Metaphyseal dysplasia (HP:0100255)1.69697138
173Advanced eruption of teeth (HP:0006288)1.69663653
174Increased connective tissue (HP:0009025)1.69490309
175Corneal dystrophy (HP:0001131)1.69454747
176Skin pits (HP:0100276)1.69397614
177Optic nerve hypoplasia (HP:0000609)1.69098785
178Heterotopia (HP:0002282)1.69066976
179Abnormality of the phalanges of the hallux (HP:0010057)1.68802104
180Camptodactyly of toe (HP:0001836)1.68120267
181Cupped ribs (HP:0000887)1.67831923
182Abnormality of molar morphology (HP:0011070)1.66332499
183Abnormality of molar (HP:0011077)1.66332499
184Cupped ear (HP:0000378)1.65137399
185Abnormality of the middle phalanges of the toes (HP:0010183)1.64799466
186Fragile nails (HP:0001808)1.64565705
187Calcaneovalgus deformity (HP:0001848)1.63671099
188Elbow flexion contracture (HP:0002987)1.62683198
189Joint stiffness (HP:0001387)1.62555780
190Flared iliac wings (HP:0002869)1.60784804
191Hyperextensible skin (HP:0000974)1.60311510
192Aortic valve stenosis (HP:0001650)1.60045454
193Stridor (HP:0010307)1.59899148

Predicted kinase interactions (KEA)

RankGene SetZ-score
1TRIB35.75874266
2CDK124.84484165
3CASK4.42801642
4BLK4.29601291
5MKNK23.48681906
6MKNK13.36143772
7EEF2K3.19671853
8EPHB23.07402901
9ICK2.22428854
10NEK61.86835393
11STK391.83567184
12WNK41.82168181
13PKN21.80059939
14TNIK1.79708471
15MTOR1.79652047
16OXSR11.78177573
17MAP3K61.77564773
18MAPK131.74288561
19BRD41.73507525
20MAP3K71.72224457
21ERN11.68278599
22PKN11.67668531
23SIK21.57809830
24INSRR1.57806493
25IRAK11.54197579
26RIPK11.54184886
27MUSK1.51007272
28DDR21.48914581
29GRK11.47847142
30PIK3CA1.45893046
31TIE11.43374211
32WNK31.42257974
33IRAK21.41686105
34SIK31.41588049
35NUAK11.40859064
36YES11.40579511
37FLT31.35591081
38EPHA21.34727582
39EPHA41.32611154
40ADRBK21.29231522
41NTRK31.27986246
42GRK71.23490752
43MAP3K101.22261334
44NEK21.21744933
45CLK11.19353819
46BMPR21.18374160
47CAMK1G1.17096391
48MAPKAPK51.16206550
49MYLK1.14691427
50MAP3K131.09605395
51TTN1.04858408
52PDGFRB1.04161732
53LATS11.03244113
54CDK31.00844506
55BMPR1B1.00842950
56KIT0.99022828
57CAMK1D0.98901337
58WNK10.97514617
59FGFR20.97174812
60MAPK150.95477615
61PRKCE0.95198548
62PLK40.93808560
63DMPK0.93542516
64MAP2K30.92409702
65BMX0.92146995
66FER0.92028577
67MST40.90597726
68PNCK0.89221961
69PRKD20.88953926
70ZAP700.88107931
71SMG10.87849872
72SRPK10.87789806
73CDK60.85283328
74IRAK30.85189890
75MST1R0.84073743
76AKT30.83880702
77PTK20.83060990
78RPS6KA20.82801738
79LATS20.82511193
80TGFBR20.82334890
81CDK80.81093742
82SIK10.81021739
83NEK90.79605081
84MAPK70.77346408
85ROCK20.76496570
86RET0.76245925
87MAP2K70.76026402
88RPS6KL10.75290720
89RPS6KC10.75290720
90ILK0.75260241
91TLK10.75073157
92STK380.74772563
93FGR0.73639562
94BCR0.73569454
95CSNK1A1L0.72928576
96CDK40.72388762
97ROCK10.72328435
98MOS0.71714612
99HIPK20.71588318
100PAK20.70252086
101ADRBK10.69284625
102PTK60.69245131
103LMTK20.68794628
104PAK40.68152106
105UHMK10.66811916
106DYRK20.65763332
107PRKG10.64220105
108EIF2AK20.63472281
109ERBB30.59565557
110CDK190.59387027
111CHEK10.59367852
112RPS6KA60.58920314
113TNK20.58677923
114CAMK2B0.58424580
115PRKD10.57481341
116CSNK1G10.56847441
117MELK0.55190267
118TGFBR10.54607112
119CAMK2A0.54350739
120MARK20.53798014
121MAPK100.53522892
122PRKCH0.52733890
123FGFR30.52179142
124IKBKE0.51175724
125EPHB10.50316069
126KSR20.48963189
127MAPK120.48819094
128PIK3CG0.48704831
129MAPK10.48672867
130CDK20.48431596
131TRPM70.48161447
132FGFR40.48076369
133MAP3K140.47534935
134PRKAA10.46682125
135NTRK10.46582402
136PDPK10.46139465
137DYRK1A0.46056844
138MAPK110.45858491
139CDK90.44976197
140MAP3K10.44259446
141CHEK20.43646465
142FES0.43575097
143PRKCI0.42338493
144GSK3A0.41633722
145PRKACA0.41272957
146CDK70.41091761
147CAMKK10.40328252
148PRPF4B0.40058430
149MAPK80.39942765
150NME10.39550657
151PLK20.38686866
152CDK10.38524193
153PDGFRA0.38363638
154GSK3B0.38085522
155RPS6KB20.38026927
156RIPK40.37875917
157CDC42BPA0.37681479
158MET0.36172430
159DYRK30.33868306
160PRKAA20.33225848
161MAP2K20.32907550
162CAMK10.32726454
163CSNK1G30.32191572
164NTRK20.32108463
165PTK2B0.31962437
166ERBB20.31862156

Predicted pathways (KEGG)

RankGene SetZ-score
1Basal cell carcinoma_Homo sapiens_hsa052172.86125264
2Chronic myeloid leukemia_Homo sapiens_hsa052202.57326774
3Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006032.48548151
4Hedgehog signaling pathway_Homo sapiens_hsa043402.46953669
5Axon guidance_Homo sapiens_hsa043602.43369056
6Taurine and hypotaurine metabolism_Homo sapiens_hsa004302.42630906
7Nicotine addiction_Homo sapiens_hsa050332.09964632
8Neuroactive ligand-receptor interaction_Homo sapiens_hsa040802.04405860
9Acute myeloid leukemia_Homo sapiens_hsa052212.01551380
10Pancreatic cancer_Homo sapiens_hsa052121.99833089
11Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006011.97838711
12Synthesis and degradation of ketone bodies_Homo sapiens_hsa000721.76924789
13Lysine degradation_Homo sapiens_hsa003101.76849539
14Other glycan degradation_Homo sapiens_hsa005111.75137594
15ECM-receptor interaction_Homo sapiens_hsa045121.71281952
16Taste transduction_Homo sapiens_hsa047421.70368105
17Cell adhesion molecules (CAMs)_Homo sapiens_hsa045141.69759910
18Phototransduction_Homo sapiens_hsa047441.68193568
19Ribosome_Homo sapiens_hsa030101.67565401
20Wnt signaling pathway_Homo sapiens_hsa043101.61338582
21Arachidonic acid metabolism_Homo sapiens_hsa005901.61112054
22Serotonergic synapse_Homo sapiens_hsa047261.60708876
23Non-small cell lung cancer_Homo sapiens_hsa052231.57913600
24Melanoma_Homo sapiens_hsa052181.55401578
25Longevity regulating pathway - mammal_Homo sapiens_hsa042111.52853066
26mTOR signaling pathway_Homo sapiens_hsa041501.52259093
27Choline metabolism in cancer_Homo sapiens_hsa052311.51415208
28Melanogenesis_Homo sapiens_hsa049161.40618764
29Arrhythmogenic right ventricular cardiomyopathy (ARVC)_Homo sapiens_hsa054121.39671129
30Longevity regulating pathway - multiple species_Homo sapiens_hsa042131.36602284
31VEGF signaling pathway_Homo sapiens_hsa043701.36430164
32Fatty acid elongation_Homo sapiens_hsa000621.35472700
33Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005121.33949227
34Bladder cancer_Homo sapiens_hsa052191.32242528
35Renal cell carcinoma_Homo sapiens_hsa052111.31899703
36Phospholipase D signaling pathway_Homo sapiens_hsa040721.31719842
37Sphingolipid metabolism_Homo sapiens_hsa006001.31673346
38Renin secretion_Homo sapiens_hsa049241.30520099
39Glioma_Homo sapiens_hsa052141.28884765
40Thyroid hormone signaling pathway_Homo sapiens_hsa049191.27120798
41Glutamatergic synapse_Homo sapiens_hsa047241.26349675
42Small cell lung cancer_Homo sapiens_hsa052221.26187127
43Colorectal cancer_Homo sapiens_hsa052101.23514011
44Ovarian steroidogenesis_Homo sapiens_hsa049131.23156198
45Glycosaminoglycan degradation_Homo sapiens_hsa005311.23093024
46Retrograde endocannabinoid signaling_Homo sapiens_hsa047231.22606937
47Steroid biosynthesis_Homo sapiens_hsa001001.22016489
48Oxidative phosphorylation_Homo sapiens_hsa001901.21915916
49Hippo signaling pathway_Homo sapiens_hsa043901.21267953
50Insulin signaling pathway_Homo sapiens_hsa049101.20898368
51Cytokine-cytokine receptor interaction_Homo sapiens_hsa040601.20477421
52Neurotrophin signaling pathway_Homo sapiens_hsa047221.19789888
53Terpenoid backbone biosynthesis_Homo sapiens_hsa009001.18837572
54Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa045501.18191628
55AMPK signaling pathway_Homo sapiens_hsa041521.16940585
56Rap1 signaling pathway_Homo sapiens_hsa040151.15120608
57mRNA surveillance pathway_Homo sapiens_hsa030151.13744541
58Endometrial cancer_Homo sapiens_hsa052131.11974398
59Ras signaling pathway_Homo sapiens_hsa040141.11926344
60TGF-beta signaling pathway_Homo sapiens_hsa043501.11821415
61Salivary secretion_Homo sapiens_hsa049701.10422084
62B cell receptor signaling pathway_Homo sapiens_hsa046621.09283271
63Morphine addiction_Homo sapiens_hsa050321.09241822
64Long-term depression_Homo sapiens_hsa047301.07762275
65Type II diabetes mellitus_Homo sapiens_hsa049301.06537354
66Estrogen signaling pathway_Homo sapiens_hsa049151.05963232
67Calcium signaling pathway_Homo sapiens_hsa040201.05470873
68Platelet activation_Homo sapiens_hsa046111.03227645
69Ether lipid metabolism_Homo sapiens_hsa005651.02504181
70Prolactin signaling pathway_Homo sapiens_hsa049171.02386109
71Protein digestion and absorption_Homo sapiens_hsa049741.01391067
72Hepatitis B_Homo sapiens_hsa051610.99672126
73Regulation of actin cytoskeleton_Homo sapiens_hsa048100.99537140
74Vascular smooth muscle contraction_Homo sapiens_hsa042700.98184263
75Insulin resistance_Homo sapiens_hsa049310.97638051
76Transcriptional misregulation in cancer_Homo sapiens_hsa052020.97371508
77Bacterial invasion of epithelial cells_Homo sapiens_hsa051000.97316346
78Fc epsilon RI signaling pathway_Homo sapiens_hsa046640.97199071
79Dorso-ventral axis formation_Homo sapiens_hsa043200.97128069
80Thyroid cancer_Homo sapiens_hsa052160.97085059
81Hypertrophic cardiomyopathy (HCM)_Homo sapiens_hsa054100.96500857
82Central carbon metabolism in cancer_Homo sapiens_hsa052300.95195531
83Alzheimers disease_Homo sapiens_hsa050100.95012118
84Cyanoamino acid metabolism_Homo sapiens_hsa004600.94784755
85Phosphatidylinositol signaling system_Homo sapiens_hsa040700.94491071
86GnRH signaling pathway_Homo sapiens_hsa049120.92743443
87Steroid hormone biosynthesis_Homo sapiens_hsa001400.92066339
88Pathways in cancer_Homo sapiens_hsa052000.91721058
89Circadian entrainment_Homo sapiens_hsa047130.91391697
90PI3K-Akt signaling pathway_Homo sapiens_hsa041510.90422146
91Focal adhesion_Homo sapiens_hsa045100.89516889
92Adipocytokine signaling pathway_Homo sapiens_hsa049200.87536349
93Inflammatory bowel disease (IBD)_Homo sapiens_hsa053210.86434034
94Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa005340.86225181
95FoxO signaling pathway_Homo sapiens_hsa040680.85955107
96Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005330.85611566
97Gastric acid secretion_Homo sapiens_hsa049710.84843972
98Dilated cardiomyopathy_Homo sapiens_hsa054140.84390870
99Inositol phosphate metabolism_Homo sapiens_hsa005620.84048060
100Rheumatoid arthritis_Homo sapiens_hsa053230.82291008
101Mineral absorption_Homo sapiens_hsa049780.78852695
102Autoimmune thyroid disease_Homo sapiens_hsa053200.78443946
103MicroRNAs in cancer_Homo sapiens_hsa052060.77113280
104Oxytocin signaling pathway_Homo sapiens_hsa049210.76924022
105Malaria_Homo sapiens_hsa051440.76660876
106GABAergic synapse_Homo sapiens_hsa047270.76448358
107HTLV-I infection_Homo sapiens_hsa051660.76267906
108Progesterone-mediated oocyte maturation_Homo sapiens_hsa049140.76114491
109cAMP signaling pathway_Homo sapiens_hsa040240.74646175
110Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005630.74095779
111RIG-I-like receptor signaling pathway_Homo sapiens_hsa046220.73387817
112Asthma_Homo sapiens_hsa053100.72078665
113Fc gamma R-mediated phagocytosis_Homo sapiens_hsa046660.71975181
114Proteoglycans in cancer_Homo sapiens_hsa052050.69628230
115Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa049610.66824882
116Chagas disease (American trypanosomiasis)_Homo sapiens_hsa051420.66284886
117Protein processing in endoplasmic reticulum_Homo sapiens_hsa041410.66278292
118Apoptosis_Homo sapiens_hsa042100.66171359
119Viral carcinogenesis_Homo sapiens_hsa052030.66038390
120Hepatitis C_Homo sapiens_hsa051600.65807012
121Parkinsons disease_Homo sapiens_hsa050120.65745023
122Glycerophospholipid metabolism_Homo sapiens_hsa005640.65507605
123Aldosterone synthesis and secretion_Homo sapiens_hsa049250.64675593
124Cardiac muscle contraction_Homo sapiens_hsa042600.64535967
125Cocaine addiction_Homo sapiens_hsa050300.64463804
126African trypanosomiasis_Homo sapiens_hsa051430.63847859
127Tight junction_Homo sapiens_hsa045300.62692588
128AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa049330.62417719
129Prostate cancer_Homo sapiens_hsa052150.62355939
130TNF signaling pathway_Homo sapiens_hsa046680.62221844
131Glucagon signaling pathway_Homo sapiens_hsa049220.61752012
132Cell cycle_Homo sapiens_hsa041100.61221451
133Retinol metabolism_Homo sapiens_hsa008300.60691747
134Fanconi anemia pathway_Homo sapiens_hsa034600.59541775
135Toxoplasmosis_Homo sapiens_hsa051450.58582449
136cGMP-PKG signaling pathway_Homo sapiens_hsa040220.55733380
137MAPK signaling pathway_Homo sapiens_hsa040100.55020274
138alpha-Linolenic acid metabolism_Homo sapiens_hsa005920.54429270
139N-Glycan biosynthesis_Homo sapiens_hsa005100.54344180
140Sphingolipid signaling pathway_Homo sapiens_hsa040710.54176886
141Other types of O-glycan biosynthesis_Homo sapiens_hsa005140.53158768
142Adherens junction_Homo sapiens_hsa045200.52208031
143Linoleic acid metabolism_Homo sapiens_hsa005910.51938450
144Influenza A_Homo sapiens_hsa051640.51462778
145Huntingtons disease_Homo sapiens_hsa050160.51255325
146Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate_Homo sapiens_hsa005320.51102723
147Cholinergic synapse_Homo sapiens_hsa047250.51086364
148Collecting duct acid secretion_Homo sapiens_hsa049660.50481534
149Amphetamine addiction_Homo sapiens_hsa050310.49107794
150SNARE interactions in vesicular transport_Homo sapiens_hsa041300.47946871
151Gap junction_Homo sapiens_hsa045400.47340735
152Amoebiasis_Homo sapiens_hsa051460.47333252
153ErbB signaling pathway_Homo sapiens_hsa040120.46295593
154Regulation of lipolysis in adipocytes_Homo sapiens_hsa049230.46238187
155Notch signaling pathway_Homo sapiens_hsa043300.45288456
156Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa051200.45231652
157Allograft rejection_Homo sapiens_hsa053300.42435890
158Graft-versus-host disease_Homo sapiens_hsa053320.41534975
159Leukocyte transendothelial migration_Homo sapiens_hsa046700.41262264
160Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049320.41199245

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