HOXB4

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: This gene is a member of the Antp homeobox family and encodes a nuclear protein with a homeobox DNA-binding domain. It is included in a cluster of homeobox B genes located on chromosome 17. The encoded protein functions as a sequence-specific transcription factor that is involved in development. Intracellular or ectopic expression of this protein expands hematopoietic stem and progenitor cells in vivo and in vitro, making it a potential candidate for therapeutic stem cell expansion. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1nuclear pore complex assembly (GO:0051292)6.17930980
2positive regulation of inositol phosphate biosynthetic process (GO:0060732)6.13215760
3negative regulation of erythrocyte differentiation (GO:0045647)5.61711164
4mesenchymal cell differentiation involved in renal system development (GO:2001012)5.25444727
5mesenchymal cell differentiation involved in kidney development (GO:0072161)5.25444727
6regulation of inositol phosphate biosynthetic process (GO:0010919)5.17307327
7DNA unwinding involved in DNA replication (GO:0006268)5.13686767
8regulation of RNA export from nucleus (GO:0046831)5.13629938
9nuclear pore organization (GO:0006999)5.11534274
10regulation of histone H3-K27 methylation (GO:0061085)4.83798155
11limb bud formation (GO:0060174)4.68790818
12pore complex assembly (GO:0046931)4.53126641
13regulation of nucleobase-containing compound transport (GO:0032239)4.35595811
14mitotic chromosome condensation (GO:0007076)4.30540124
15daunorubicin metabolic process (GO:0044597)4.09472993
16polyketide metabolic process (GO:0030638)4.09472993
17doxorubicin metabolic process (GO:0044598)4.09472993
18histone H3-K36 demethylation (GO:0070544)4.06745925
19mitotic sister chromatid segregation (GO:0000070)4.03301414
20head development (GO:0060322)4.02242291
21heterochromatin organization (GO:0070828)3.98901627
22DNA topological change (GO:0006265)3.95646687
23lateral sprouting from an epithelium (GO:0060601)3.95241303
24sister chromatid segregation (GO:0000819)3.91380068
25cranial nerve morphogenesis (GO:0021602)3.86842414
26regulation of histone H3-K4 methylation (GO:0051569)3.85591144
27cerebral cortex radially oriented cell migration (GO:0021799)3.81540718
28mesenchymal-epithelial cell signaling (GO:0060638)3.77713387
29presynaptic membrane assembly (GO:0097105)3.76017298
30opioid receptor signaling pathway (GO:0038003)3.75094903
31cranial nerve structural organization (GO:0021604)3.74494925
32glucocorticoid receptor signaling pathway (GO:0042921)3.69422575
33mitotic sister chromatid cohesion (GO:0007064)3.68982398
34regulation of pigment cell differentiation (GO:0050932)3.65133285
35DNA replication initiation (GO:0006270)3.64539333
36mitotic nuclear envelope disassembly (GO:0007077)3.61468626
37nucleosome disassembly (GO:0006337)3.56248729
38protein-DNA complex disassembly (GO:0032986)3.56248729
39positive regulation of alcohol biosynthetic process (GO:1902932)3.54957056
40cell proliferation in forebrain (GO:0021846)3.54327206
41mesonephros development (GO:0001823)3.51532497
42righting reflex (GO:0060013)3.50854513
43regulation of insulin-like growth factor receptor signaling pathway (GO:0043567)3.50791613
44embryonic forelimb morphogenesis (GO:0035115)3.50310142
45L-fucose catabolic process (GO:0042355)3.49955078
46fucose catabolic process (GO:0019317)3.49955078
47L-fucose metabolic process (GO:0042354)3.49955078
48cell differentiation involved in metanephros development (GO:0072202)3.49604995
49regulation of mitotic spindle organization (GO:0060236)3.49017353
50negative regulation of homotypic cell-cell adhesion (GO:0034111)3.48211567
51mesenchymal cell differentiation (GO:0048762)3.43885157
52branch elongation of an epithelium (GO:0060602)3.42972801
53regulation of branching involved in salivary gland morphogenesis (GO:0060693)3.42207846
54chromatin assembly (GO:0031497)3.41192082
55regulation of transcription involved in G1/S transition of mitotic cell cycle (GO:0000083)3.40931584
56nuclear envelope disassembly (GO:0051081)3.39938441
57membrane disassembly (GO:0030397)3.39938441
58negative regulation of histone methylation (GO:0031061)3.39761853
59anatomical structure arrangement (GO:0048532)3.38513854
60DNA replication checkpoint (GO:0000076)3.37674110
61regulation of translational fidelity (GO:0006450)3.37274919
62negative regulation of mRNA splicing, via spliceosome (GO:0048025)3.37237456
63formation of translation preinitiation complex (GO:0001731)3.34433130
64positive regulation of cyclin-dependent protein serine/threonine kinase activity involved in G1/S tr3.32548554
65postsynaptic membrane organization (GO:0001941)3.32492478
66retina layer formation (GO:0010842)3.32125158
67corticosteroid receptor signaling pathway (GO:0031958)3.30121772
68developmental induction (GO:0031128)3.30022385
69determination of adult lifespan (GO:0008340)3.29513046
70facial nerve structural organization (GO:0021612)3.26879767
71aminoglycoside antibiotic metabolic process (GO:0030647)3.24873929
72presynaptic membrane organization (GO:0097090)3.24465019
73cell-cell signaling involved in cell fate commitment (GO:0045168)3.24004416
74L-amino acid import (GO:0043092)3.23850830
75neuron recognition (GO:0008038)3.22536763
76interkinetic nuclear migration (GO:0022027)3.20902832
77mRNA stabilization (GO:0048255)3.19335720
78RNA stabilization (GO:0043489)3.19335720
79organ growth (GO:0035265)3.15966102
80cell differentiation involved in kidney development (GO:0061005)3.15542815
81regulation of histone methylation (GO:0031060)3.14810077
82neuron remodeling (GO:0016322)3.13592369
83forelimb morphogenesis (GO:0035136)3.13279468
84kidney morphogenesis (GO:0060993)3.13159850
85mRNA cleavage (GO:0006379)3.12548088
86neuron cell-cell adhesion (GO:0007158)3.10654901
87poly(A)+ mRNA export from nucleus (GO:0016973)3.09800010
88positive regulation of DNA-dependent DNA replication (GO:2000105)3.05624261
89axon ensheathment in central nervous system (GO:0032291)3.04138993
90central nervous system myelination (GO:0022010)3.04138993
91negative regulation of peptidyl-threonine phosphorylation (GO:0010801)3.03901463
92keratinocyte development (GO:0003334)3.03868523
93DNA duplex unwinding (GO:0032508)3.02114341
94protein export from nucleus (GO:0006611)3.01924080
95dosage compensation (GO:0007549)3.01056045
96DNA strand elongation involved in DNA replication (GO:0006271)3.00085866
97short-term memory (GO:0007614)2.96564133
98positive regulation of gene expression, epigenetic (GO:0045815)2.96465140
99DNA conformation change (GO:0071103)2.95835348
100radial glial cell differentiation (GO:0060019)2.95762425
101chromosome condensation (GO:0030261)2.93501428
102positive regulation of RNA splicing (GO:0033120)2.93144675
103DNA strand elongation (GO:0022616)2.92153117
104regulation of alpha-amino-3-hydroxy-5-methyl-4-isoxazole propionate selective glutamate receptor act2.91773800
105thyroid gland development (GO:0030878)2.89776728
106regulation of DNA damage checkpoint (GO:2000001)2.88592518
107nuclear envelope organization (GO:0006998)2.87876125
108otic vesicle formation (GO:0030916)2.87744133
109viral mRNA export from host cell nucleus (GO:0046784)2.87091178
110retina vasculature morphogenesis in camera-type eye (GO:0061299)2.84237178
111regulation of platelet aggregation (GO:0090330)2.83678593
112DNA geometric change (GO:0032392)2.83415567
113respiratory tube development (GO:0030323)2.83117235
114* embryonic skeletal system morphogenesis (GO:0048704)2.81038806
115positive regulation of protein kinase C signaling (GO:0090037)2.80603869
116protein localization to synapse (GO:0035418)2.79804727
117response to epinephrine (GO:0071871)2.79339186
118regulation of mammary gland epithelial cell proliferation (GO:0033599)2.79212245
119DNA synthesis involved in DNA repair (GO:0000731)2.77719235
120adrenergic receptor signaling pathway (GO:0071875)2.77239650
121import into cell (GO:0098657)2.76746841
122negative regulation of fibroblast growth factor receptor signaling pathway (GO:0040037)2.75576949
123cerebral cortex cell migration (GO:0021795)2.75183656
124DNA packaging (GO:0006323)2.75106757
125mRNA transport (GO:0051028)2.74877571
126long-chain fatty acid biosynthetic process (GO:0042759)2.74347720
127proximal/distal pattern formation (GO:0009954)2.74119135
128protein localization to chromosome, centromeric region (GO:0071459)2.73942058
129gamma-aminobutyric acid signaling pathway (GO:0007214)2.73019154
130pre-miRNA processing (GO:0031054)2.71989870
131vocalization behavior (GO:0071625)2.71589057
132positive regulation of protein import into nucleus, translocation (GO:0033160)2.71565392
133lymph vessel development (GO:0001945)2.70075840
134regulation of Arp2/3 complex-mediated actin nucleation (GO:0034315)2.68844117
135cytoplasmic mRNA processing body assembly (GO:0033962)2.64181066
136folic acid-containing compound biosynthetic process (GO:0009396)2.63562781
137positive regulation of meiosis (GO:0045836)2.63137527
138negative regulation of DNA repair (GO:0045738)2.63076461
139cornea development in camera-type eye (GO:0061303)2.62886020
140ovulation cycle (GO:0042698)2.62690400
141regulation of glucose import in response to insulin stimulus (GO:2001273)2.62410560
142ionotropic glutamate receptor signaling pathway (GO:0035235)2.62086823
143positive regulation of cardiac muscle cell differentiation (GO:2000727)2.61897661
144regulation of Wnt signaling pathway, planar cell polarity pathway (GO:2000095)2.61463995
145positive regulation of odontogenesis (GO:0042482)2.61177424
146histone phosphorylation (GO:0016572)2.60672517
147regulation of non-canonical Wnt signaling pathway (GO:2000050)2.60074579
148negative regulation of mRNA processing (GO:0050686)2.59708418
149regulation of cyclin-dependent protein serine/threonine kinase activity involved in G1/S transition 2.59568364
150negative regulation of systemic arterial blood pressure (GO:0003085)2.59150017
151glutamate receptor signaling pathway (GO:0007215)2.58389871
152positive regulation of bone mineralization (GO:0030501)2.58094943
153negative regulation of mRNA metabolic process (GO:1903312)2.57755903
154cellular response to epinephrine stimulus (GO:0071872)2.57397063
155response to epidermal growth factor (GO:0070849)2.57284424
156face development (GO:0060324)2.57039584
1573-UTR-mediated mRNA stabilization (GO:0070935)2.56592309
158epithelial to mesenchymal transition involved in endocardial cushion formation (GO:0003198)2.55669421
159histone methylation (GO:0016571)2.55497935
160histone H3-K4 methylation (GO:0051568)2.55422779
161axis elongation (GO:0003401)2.54055946
162histone lysine methylation (GO:0034968)2.53238496
163monoubiquitinated protein deubiquitination (GO:0035520)2.52944518
164COPI coating of Golgi vesicle (GO:0048205)2.51423965
165Golgi transport vesicle coating (GO:0048200)2.51423965
166negative regulation of RNA splicing (GO:0033119)2.50938466
167regulation of spindle organization (GO:0090224)2.50632915
168megakaryocyte development (GO:0035855)2.50550480
169chromatin assembly or disassembly (GO:0006333)2.50483255
170polyol transport (GO:0015791)2.50370666
171organ induction (GO:0001759)2.50198615
172telomere maintenance via semi-conservative replication (GO:0032201)2.50099176
173axonal fasciculation (GO:0007413)2.49544782
174transmission of nerve impulse (GO:0019226)2.48015596
175negative regulation of smooth muscle cell differentiation (GO:0051151)2.48006092
176lung secretory cell differentiation (GO:0061140)2.47451639
177fucosylation (GO:0036065)2.47297199
178granulocyte differentiation (GO:0030851)2.46467793
179regulation of timing of cell differentiation (GO:0048505)2.46199376
180positive regulation of synapse assembly (GO:0051965)2.45756795
181DNA integration (GO:0015074)2.45725628
182trophoblast giant cell differentiation (GO:0060707)2.45586333
183* definitive hemopoiesis (GO:0060216)2.45070603
184* embryonic organ morphogenesis (GO:0048562)2.44934477
185* anterior/posterior pattern specification (GO:0009952)2.43883643
186regulation of histone H3-K9 methylation (GO:0051570)2.43652127
187positive regulation of blood vessel endothelial cell migration (GO:0043536)2.42420325
188cochlea morphogenesis (GO:0090103)2.41879399
189mesenchymal to epithelial transition (GO:0060231)2.41753108
190meiotic chromosome segregation (GO:0045132)2.40422214
191erythrocyte maturation (GO:0043249)2.39964052
192regulation of erythrocyte differentiation (GO:0045646)2.39519310
193positive regulation of meiotic cell cycle (GO:0051446)2.39408133
194neural tube development (GO:0021915)2.39349532

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1E2F7_22180533_ChIP-Seq_HELA_Human8.17217513
2EGR1_19374776_ChIP-ChIP_THP-1_Human5.00897557
3FOXM1_23109430_ChIP-Seq_U2OS_Human4.57151396
4EZH2_22144423_ChIP-Seq_EOC_Human3.91162019
5MYC_22102868_ChIP-Seq_BL_Human3.44767136
6GBX2_23144817_ChIP-Seq_PC3_Human3.21601381
7* JARID2_20064375_ChIP-Seq_MESCs_Mouse3.20649593
8* EED_16625203_ChIP-ChIP_MESCs_Mouse3.00089442
9* EZH2_27304074_Chip-Seq_ESCs_Mouse2.97015085
10E2F4_17652178_ChIP-ChIP_JURKAT_Human2.95317766
11CBX2_27304074_Chip-Seq_ESCs_Mouse2.83613106
12* SUZ12_18692474_ChIP-Seq_MESCs_Mouse2.74776314
13VDR_21846776_ChIP-Seq_THP-1_Human2.70914680
14* RNF2_18974828_ChIP-Seq_MESCs_Mouse2.67172701
15* EZH2_18974828_ChIP-Seq_MESCs_Mouse2.67172701
16* SUZ12_18555785_ChIP-Seq_MESCs_Mouse2.66150581
17* SUZ12_18692474_ChIP-Seq_MEFs_Mouse2.63970782
18* BMI1_23680149_ChIP-Seq_NPCS_Mouse2.63789029
19* SUZ12_16625203_ChIP-ChIP_MESCs_Mouse2.62211453
20FOXM1_25889361_ChIP-Seq_OE33_AND_U2OS_Human2.60991020
21BP1_19119308_ChIP-ChIP_Hs578T_Human2.59706050
22* SUZ12_18974828_ChIP-Seq_MESCs_Mouse2.56870844
23HCFC1_20581084_ChIP-Seq_MESCs_Mouse2.54852728
24* JARID2_20075857_ChIP-Seq_MESCs_Mouse2.50038578
25AR_21572438_ChIP-Seq_LNCaP_Human2.48139857
26EKLF_21900194_ChIP-Seq_ERYTHROCYTE_Mouse2.45213258
27MYBL1_21750041_ChIP-ChIP_SPERMATOCYTES_Mouse2.39937304
28TBP_23326641_ChIP-Seq_C3H10T1-2_Mouse2.39230933
29MYC_18555785_ChIP-Seq_MESCs_Mouse2.38007857
30NUCKS1_24931609_ChIP-Seq_HEPATOCYTES_Mouse2.32574034
31TAF15_26573619_Chip-Seq_HEK293_Human2.32193777
32ELK3_25401928_ChIP-Seq_HUVEC_Human2.31722080
33KDM2B_26808549_Chip-Seq_SIL-ALL_Human2.25312064
34VDR_22108803_ChIP-Seq_LS180_Human2.23322637
35NCOR1_26117541_ChIP-Seq_K562_Human2.22817597
36ZFP57_27257070_Chip-Seq_ESCs_Mouse2.22522299
37* RNF2_27304074_Chip-Seq_NSC_Mouse2.12491396
38RNF2_27304074_Chip-Seq_ESCs_Mouse2.10658729
39GATA1_22025678_ChIP-Seq_K562_Human2.09064716
40CDX2_19796622_ChIP-Seq_MESCs_Mouse2.06654028
41WT1_19549856_ChIP-ChIP_CCG9911_Human2.06440132
42* PHC1_16625203_ChIP-ChIP_MESCs_Mouse2.04154750
43GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse2.03007035
44E2F1_21310950_ChIP-Seq_MCF-7_Human2.01154010
45* RNF2_16625203_ChIP-ChIP_MESCs_Mouse1.99245088
46IGF1R_20145208_ChIP-Seq_DFB_Human1.95319373
47* KDM5B_21448134_ChIP-Seq_MESCs_Mouse1.94714281
48XRN2_22483619_ChIP-Seq_HELA_Human1.94365523
49* MTF2_20144788_ChIP-Seq_MESCs_Mouse1.92661108
50PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human1.88650041
51TP63_19390658_ChIP-ChIP_HaCaT_Human1.88255003
52CIITA_25753668_ChIP-Seq_RAJI_Human1.87977525
53GLI1_17442700_ChIP-ChIP_MESCs_Mouse1.87596168
54CEBPD_23245923_ChIP-Seq_MEFs_Mouse1.86978468
55* EZH2_27294783_Chip-Seq_ESCs_Mouse1.85664691
56* SUZ12_27294783_Chip-Seq_ESCs_Mouse1.83547747
57* POU5F1_16153702_ChIP-ChIP_HESCs_Human1.79945235
58CREB1_23762244_ChIP-Seq_HIPPOCAMPUS_Rat1.77556485
59P300_19829295_ChIP-Seq_ESCs_Human1.77508305
60ZNF263_19887448_ChIP-Seq_K562_Human1.77035962
61MYC_19079543_ChIP-ChIP_MESCs_Mouse1.75312494
62FUS_26573619_Chip-Seq_HEK293_Human1.73789159
63TCF7_22412390_ChIP-Seq_EML_Mouse1.72791747
64GATA1_19941826_ChIP-Seq_K562_Human1.71897509
65CTBP1_25329375_ChIP-Seq_LNCAP_Human1.71645795
66KDM2B_26808549_Chip-Seq_HPB-ALL_Human1.70869364
67IKZF1_21737484_ChIP-ChIP_HCT116_Human1.69560682
68KDM2B_26808549_Chip-Seq_DND41_Human1.68752587
69* SUZ12_20075857_ChIP-Seq_MESCs_Mouse1.67696664
70PIAS1_25552417_ChIP-Seq_VCAP_Human1.65079494
71DACH1_20351289_ChIP-Seq_MDA-MB-231_Human1.63239251
72CTBP2_25329375_ChIP-Seq_LNCAP_Human1.62747954
73KDM2B_26808549_Chip-Seq_SUP-B15_Human1.59895271
74SCL_19346495_ChIP-Seq_HPC-7_Human1.59522640
75POU3F2_20337985_ChIP-ChIP_501MEL_Human1.58758892
76TP53_18474530_ChIP-ChIP_U2OS_Human1.56640634
77* CREB1_20920259_ChIP-Seq_GC1-SPG_Mouse1.54337193
78CCND1_20090754_ChIP-ChIP_RETINA_Mouse1.52764527
79EZH2_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse1.48884488
80SMAD3_21741376_ChIP-Seq_EPCs_Human1.48599021
81KDM2B_26808549_Chip-Seq_JURKAT_Human1.47039626
82MAF_26560356_Chip-Seq_TH1_Human1.46942598
83MYC_19030024_ChIP-ChIP_MESCs_Mouse1.46248190
84TTF2_22483619_ChIP-Seq_HELA_Human1.45875783
85* TP53_20018659_ChIP-ChIP_R1E_Mouse1.45673853
86FLI1_27457419_Chip-Seq_LIVER_Mouse1.45523780
87MYC_18358816_ChIP-ChIP_MESCs_Mouse1.45211998
88KDM5A_27292631_Chip-Seq_BREAST_Human1.44409883
89KLF6_26769127_Chip-Seq_PDAC-Cell_line_Human1.42408406
90OLIG2_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.42031116
91AR_21909140_ChIP-Seq_LNCAP_Human1.40468740
92UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human1.40057554
93TOP2B_26459242_ChIP-Seq_MCF-7_Human1.35386534
94P300_27058665_Chip-Seq_ZR-75-30cells_Human1.33895972
95SMAD4_21799915_ChIP-Seq_A2780_Human1.33615814
96ZNF217_24962896_ChIP-Seq_MCF-7_Human1.30717577
97SMARCD1_25818293_ChIP-Seq_ESCs_Mouse1.29936582
98TAL1_20887958_ChIP-Seq_HPC-7_Mouse1.28237013
99ARNT_22903824_ChIP-Seq_MCF-7_Human1.28172566
100VDR_24763502_ChIP-Seq_THP-1_Human1.28086248
101ZFX_18555785_ChIP-Seq_MESCs_Mouse1.27940226
102SMAD_19615063_ChIP-ChIP_OVARY_Human1.27873154
103SPI1_23127762_ChIP-Seq_K562_Human1.27491719
104KDM2B_26808549_Chip-Seq_K562_Human1.27383823
105VDR_23401126_ChIP-Seq_LCL-AND-THP1_Human1.27056676
106SMAD2/3_21741376_ChIP-Seq_EPCs_Human1.26814181
107KLF4_26769127_Chip-Seq_PDAC-Cell_line_Human1.26746547
108ASXL1_24218140_ChIP-Seq_BMDM_Mouse1.26454510
109PRDM5_23873026_ChIP-Seq_MEFs_Mouse1.26449582
110LXR_22292898_ChIP-Seq_THP-1_Human1.24884914
111TP53_16413492_ChIP-PET_HCT116_Human1.24808895
112NANOG_18555785_Chip-Seq_ESCs_Mouse1.24286978
113* RING1B_27294783_Chip-Seq_NPCs_Mouse1.23692853
114CREM_20920259_ChIP-Seq_GC1-SPG_Mouse1.23552004
115TAL1_20566737_ChIP-Seq_PRIMARY_FETAL_LIVER_ERYTHROID_Mouse1.23150100
116PCGF2_27294783_Chip-Seq_ESCs_Mouse1.22237095
117SMARCA4_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.21732911
118TAL1_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.21641929
119STAT6_21828071_ChIP-Seq_BEAS2B_Human1.21458025
120POU5F1_18555785_ChIP-Seq_MESCs_Mouse1.21082907
121* RACK7_27058665_Chip-Seq_MCF-7_Human1.20866295
122UTX_26944678_Chip-Seq_JUKART_Human1.20841821
123POU5F1_26923725_Chip-Seq_MESODERM_Mouse1.20727713
124TEAD4_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.20727713
125NELFA_20434984_ChIP-Seq_ESCs_Mouse1.20258567
126MYCN_18555785_ChIP-Seq_MESCs_Mouse1.20092548
127TRIM28_17542650_ChIP-ChIP_NTERA2_Human1.19425976
128* KLF4_19030024_ChIP-ChIP_MESCs_Mouse1.19081197
129TCFCP2L1_18555785_Chip-Seq_ESCs_Mouse1.19021511
130E2F1_18555785_Chip-Seq_ESCs_Mouse1.18796127
131YY1_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse1.18479381
132MAF_26560356_Chip-Seq_TH2_Human1.18053019
133PKCTHETA_26484144_Chip-Seq_BREAST_Human1.17506322
134CIITA_18437201_ChIP-ChIP_Raji_B_and_iDC_Human1.17401860
135DMRT1_23473982_ChIP-Seq_TESTES_Mouse1.17018787
136ER_23166858_ChIP-Seq_MCF-7_Human1.16876039
137PCGF2_27294783_Chip-Seq_NPCs_Mouse1.16193941
138GATA2_19941826_ChIP-Seq_K562_Human1.16096352
139EBF1_22473956_ChIP-Seq_BONE_MARROW_Mouse1.15656677
140RUNX2_22187159_ChIP-Seq_PCA_Human1.14772257
141* RING1B_27294783_Chip-Seq_ESCs_Mouse1.14724367
142MYBL2_22936984_ChIP-ChIP_MESCs_Mouse1.14263008
143PPARG_19300518_ChIP-PET_3T3-L1_Mouse1.14255873
144RARG_19884340_ChIP-ChIP_MEFs_Mouse1.14147059
145KLF4_18555785_ChIP-Seq_MESCs_Mouse1.13448147
146THAP11_20581084_ChIP-Seq_MESCs_Mouse1.13310985
147HSF1_23293686_ChIP-Seq_STHDH_STRIATAL_Mouse1.13124300
148DCP1A_22483619_ChIP-Seq_HELA_Human1.12789702
149AR_25329375_ChIP-Seq_VCAP_Human1.12294146
150CHD7_19251738_ChIP-ChIP_MESCs_Mouse1.11895997
151SUZ12_18555785_Chip-Seq_ESCs_Mouse1.10717839
152CHD1_26751641_Chip-Seq_LNCaP_Human1.09861372
153RUNX2_24764292_ChIP-Seq_MC3T3_Mouse1.09745467
154* WT1_20215353_ChIP-ChIP_NEPHRON_PROGENITOR_Mouse1.09263415
155STAT3_1855785_ChIP-Seq_MESCs_Mouse1.09210541
156CMYC_18555785_Chip-Seq_ESCs_Mouse1.08780423
157* CTCF_27219007_Chip-Seq_ERYTHROID_Human1.08013493
158UBF1/2_26484160_Chip-Seq_HMECs_Human1.06496098
159AHR_22903824_ChIP-Seq_MCF-7_Human1.06093611
160* ZFP281_27345836_Chip-Seq_ESCs_Mouse1.05887431
161P53_22387025_ChIP-Seq_ESCs_Mouse1.05371205
162* KLF5_18264089_ChIP-ChIP_MESCs_Mouse1.05103173
163* KLF4_18264089_ChIP-ChIP_MESCs_Mouse1.05103173
164* KLF2_18264089_ChIP-ChIP_MESCs_Mouse1.05103173
165CEBPB_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.05052190
166CNOT3_19339689_ChIP-ChIP_MESCs_Mouse1.04735366
167SUZ12_27294783_Chip-Seq_NPCs_Mouse1.04353098
168AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human1.03376171
169NR3C1_21868756_ChIP-Seq_MCF10A_Human1.03165407
170ZNF274_21170338_ChIP-Seq_K562_Hela1.02972891
171TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.02541627
172ERG_20887958_ChIP-Seq_HPC-7_Mouse1.02447960
173IRF1_19129219_ChIP-ChIP_H3396_Human1.01900704
174STAT3_18555785_Chip-Seq_ESCs_Mouse1.01368484
175CREB1_26743006_Chip-Seq_LNCaP_Human1.01355585
176MYB_26560356_Chip-Seq_TH1_Human1.00750996
177EBF1_22473956_ChIP-Seq_LYMPHODE_Mouse1.00406227
178EWS_26573619_Chip-Seq_HEK293_Human1.00245189
179P300_18555785_Chip-Seq_ESCs_Mouse0.99629085
180* CDX2_20551321_ChIP-Seq_CACO-2_Human0.99473205
181* GATA1_22383799_ChIP-Seq_G1ME_Mouse0.98641898
182STAT3_24763339_ChIP-Seq_IMN-ESCs_Mouse0.98087948
183STAT3_23295773_ChIP-Seq_U87_Human0.98081394
184CEBPB_26923725_Chip-Seq_MESODERM_Mouse0.97669387
185SMAD3_21741376_ChIP-Seq_HESCs_Human0.97190172
186ESR1_22446102_ChIP-Seq_UTERUS_Mouse0.96570482
187ESR1_20079471_ChIP-ChIP_T-47D_Human0.96524942
188NKX2-5_21415370_ChIP-Seq_HL-1_Mouse0.95435947
189SFPI1_20887958_ChIP-Seq_HPC-7_Mouse0.95198874
190FOXM1_26100407_CHIP-SEQ_Hek293_flp-in_Human0.94538210
191FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse0.93394016
192SMAD1_18555785_ChIP-Seq_MESCs_Mouse0.92855228
193* EGR1_20690147_ChIP-Seq_ERYTHROLEUKEMIA_Human0.91782639
194GFI1B_20887958_ChIP-Seq_HPC-7_Mouse0.91779434
195UBF1/2_26484160_Chip-Seq_HMEC-DERIVED_Human0.91673439
196ATF3_27146783_Chip-Seq_COLON_Human0.91629562
197SPI1_22790984_ChIP-Seq_ERYTHROLEUKEMIA_Mouse0.91225349
198CLOCK_20551151_ChIP-Seq_293T_Human0.90951498

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0002102_abnormal_ear_morphology5.02281730
2MP0006292_abnormal_olfactory_placode4.07451059
3MP0003136_yellow_coat_color3.54105402
4MP0002249_abnormal_larynx_morphology3.26356479
5MP0005409_darkened_coat_color3.25710185
6MP0003938_abnormal_ear_development3.10024178
7MP0003111_abnormal_nucleus_morphology3.09601411
8MP0009250_abnormal_appendicular_skeleto2.98886812
9MP0001188_hyperpigmentation2.88308148
10MP0010094_abnormal_chromosome_stability2.72628252
11MP0008057_abnormal_DNA_replication2.60603752
12MP0005076_abnormal_cell_differentiation2.58005097
13MP0000049_abnormal_middle_ear2.58003260
14MP0002396_abnormal_hematopoietic_system2.52769753
15MP0000678_abnormal_parathyroid_gland2.49029875
16MP0003705_abnormal_hypodermis_morpholog2.46821878
17MP0003693_abnormal_embryo_hatching2.44007985
18MP0000566_synostosis2.40751710
19MP0001661_extended_life_span2.38740636
20MP0005248_abnormal_Harderian_gland2.38377102
21MP0002877_abnormal_melanocyte_morpholog2.29179906
22MP0008438_abnormal_cutaneous_collagen2.25805491
23MP0003077_abnormal_cell_cycle2.22390420
24MP0008260_abnormal_autophagy2.20302610
25MP0003880_abnormal_central_pattern2.15807351
26MP0004808_abnormal_hematopoietic_stem2.14506126
27MP0003937_abnormal_limbs/digits/tail_de2.10131778
28MP0004957_abnormal_blastocyst_morpholog2.06128624
29MP0000681_abnormal_thyroid_gland2.01778063
30MP0001545_abnormal_hematopoietic_system1.96642087
31MP0005397_hematopoietic_system_phenotyp1.96642087
32MP0000015_abnormal_ear_pigmentation1.95135773
33MP0004742_abnormal_vestibular_system1.94984036
34MP0000631_abnormal_neuroendocrine_gland1.94856471
35MP0009697_abnormal_copulation1.93383512
36MP0002277_abnormal_respiratory_mucosa1.91320796
37MP0000026_abnormal_inner_ear1.88704700
38MP0005174_abnormal_tail_pigmentation1.87931247
39MP0001348_abnormal_lacrimal_gland1.86270022
40MP0005451_abnormal_body_composition1.82181703
41MP0000350_abnormal_cell_proliferation1.79601619
42MP0001486_abnormal_startle_reflex1.78925725
43MP0004185_abnormal_adipocyte_glucose1.77539750
44MP0003283_abnormal_digestive_organ1.76374187
45MP0010307_abnormal_tumor_latency1.76211839
46MP0008932_abnormal_embryonic_tissue1.75082052
47MP0008007_abnormal_cellular_replicative1.72655901
48* MP0003385_abnormal_body_wall1.69147700
49MP0002177_abnormal_outer_ear1.67847616
50MP0010352_gastrointestinal_tract_polyps1.63016311
51MP0000733_abnormal_muscle_development1.59162175
52MP0000569_abnormal_digit_pigmentation1.59013653
53MP0009278_abnormal_bone_marrow1.57549854
54MP0004381_abnormal_hair_follicle1.55362989
55MP0001730_embryonic_growth_arrest1.54494443
56MP0001963_abnormal_hearing_physiology1.46919572
57MP0001697_abnormal_embryo_size1.44820876
58MP0009379_abnormal_foot_pigmentation1.43052283
59MP0004859_abnormal_synaptic_plasticity1.42313085
60MP0002009_preneoplasia1.41557092
61MP0008058_abnormal_DNA_repair1.40658314
62MP0005380_embryogenesis_phenotype1.40500950
63MP0001672_abnormal_embryogenesis/_devel1.40500950
64MP0004197_abnormal_fetal_growth/weight/1.40358275
65MP0001501_abnormal_sleep_pattern1.39379669
66MP0002233_abnormal_nose_morphology1.39026568
67MP0003984_embryonic_growth_retardation1.38644237
68MP0003315_abnormal_perineum_morphology1.37382866
69MP0005171_absent_coat_pigmentation1.37347020
70MP0002086_abnormal_extraembryonic_tissu1.35247827
71MP0002080_prenatal_lethality1.34098573
72MP0009046_muscle_twitch1.33645809
73MP0002116_abnormal_craniofacial_bone1.33424338
74MP0000920_abnormal_myelination1.33354956
75MP0001879_abnormal_lymphatic_vessel1.32560555
76MP0009053_abnormal_anal_canal1.32437444
77MP0004885_abnormal_endolymph1.30773559
78MP0003122_maternal_imprinting1.30269312
79MP0002088_abnormal_embryonic_growth/wei1.29824106
80MP0000762_abnormal_tongue_morphology1.28935600
81MP0009745_abnormal_behavioral_response1.28342969
82MP0003635_abnormal_synaptic_transmissio1.28124896
83MP0004233_abnormal_muscle_weight1.27829368
84MP0002085_abnormal_embryonic_tissue1.26184803
85MP0000428_abnormal_craniofacial_morphol1.24905432
86MP0006276_abnormal_autonomic_nervous1.22894671
87MP0004272_abnormal_basement_membrane1.22869578
88MP0000432_abnormal_head_morphology1.22842032
89MP0003755_abnormal_palate_morphology1.22411866
90MP0002876_abnormal_thyroid_physiology1.21954895
91MP0003172_abnormal_lysosome_physiology1.20286303
92MP0000313_abnormal_cell_death1.19439154
93MP0002067_abnormal_sensory_capabilities1.15762829
94MP0002109_abnormal_limb_morphology1.14379481
95MP0002089_abnormal_postnatal_growth/wei1.13529841
96MP0001664_abnormal_digestion1.11515058
97MP0003279_aneurysm1.11137522
98MP0002084_abnormal_developmental_patter1.11126597
99MP0003690_abnormal_glial_cell1.08106763
100MP0000703_abnormal_thymus_morphology1.07562180
101MP0008961_abnormal_basal_metabolism1.07364067
102MP0000778_abnormal_nervous_system1.07083045
103MP0003959_abnormal_lean_body1.06206723
104MP0002108_abnormal_muscle_morphology1.05134667
105MP0003786_premature_aging1.04034221
106MP0008995_early_reproductive_senescence1.04022739
107MP0003656_abnormal_erythrocyte_physiolo1.03258491
108MP0002295_abnormal_pulmonary_circulatio1.02967445
109MP0001905_abnormal_dopamine_level1.02589779
110MP0003115_abnormal_respiratory_system1.02030588
111MP0001485_abnormal_pinna_reflex1.01126966
112MP0002572_abnormal_emotion/affect_behav1.01064956
113MP0002132_abnormal_respiratory_system1.00709259
114MP0003950_abnormal_plasma_membrane1.00533661
115MP0000163_abnormal_cartilage_morphology0.99653051
116MP0002938_white_spotting0.99156748
117MP0005508_abnormal_skeleton_morphology0.98946359
118MP0001727_abnormal_embryo_implantation0.98266708
119MP0001968_abnormal_touch/_nociception0.98022403
120MP0000516_abnormal_urinary_system0.97948511
121MP0005367_renal/urinary_system_phenotyp0.97948511
122MP0002272_abnormal_nervous_system0.96971519
123* MP0000759_abnormal_skeletal_muscle0.96704015
124MP0002557_abnormal_social/conspecific_i0.96473379
125MP0005645_abnormal_hypothalamus_physiol0.94762043
126MP0002064_seizures0.94464398
127MP0004145_abnormal_muscle_electrophysio0.93824962
128MP0001346_abnormal_lacrimal_gland0.93520396
129MP0002925_abnormal_cardiovascular_devel0.92849002
130MP0000537_abnormal_urethra_morphology0.92589031
131MP0002063_abnormal_learning/memory/cond0.91795648
132MP0010630_abnormal_cardiac_muscle0.91546198
133MP0004043_abnormal_pH_regulation0.91377915
134MP0003890_abnormal_embryonic-extraembry0.90139845
135MP0002752_abnormal_somatic_nervous0.89717738
136MP0000767_abnormal_smooth_muscle0.89371525
137MP0005058_abnormal_lysosome_morphology0.88297415
138* MP0002114_abnormal_axial_skeleton0.88054380
139MP0000465_gastrointestinal_hemorrhage0.87726845
140MP0002735_abnormal_chemical_nociception0.86477399
141MP0000747_muscle_weakness0.86004433
142MP0006082_CNS_inflammation0.85616856
143MP0002019_abnormal_tumor_incidence0.85534448
144MP0005666_abnormal_adipose_tissue0.84490955
145MP0010368_abnormal_lymphatic_system0.84002935
146MP0002932_abnormal_joint_morphology0.83998936
147MP0009672_abnormal_birth_weight0.82815497
148MP0010386_abnormal_urinary_bladder0.82525342
149MP0002998_abnormal_bone_remodeling0.82157190
150MP0004782_abnormal_surfactant_physiolog0.81478992
151MP0005623_abnormal_meninges_morphology0.81000992
152MP0004142_abnormal_muscle_tone0.79884600
153MP0003935_abnormal_craniofacial_develop0.79850931
154MP0003724_increased_susceptibility_to0.79545084
155MP0005670_abnormal_white_adipose0.79380336
156MP0002970_abnormal_white_adipose0.78881282
157MP0005503_abnormal_tendon_morphology0.78719906
158MP0000462_abnormal_digestive_system0.78443835
159MP0002184_abnormal_innervation0.78157065
160MP0003942_abnormal_urinary_system0.77665205
161MP0003787_abnormal_imprinting0.77527653
162MP0000467_abnormal_esophagus_morphology0.75592497
163MP0002115_abnormal_skeleton_extremities0.74998754
164MP0005621_abnormal_cell_physiology0.74964736
165MP0003943_abnormal_hepatobiliary_system0.74753754
166MP0005595_abnormal_vascular_smooth0.74152272
167MP0005310_abnormal_salivary_gland0.73553445
168* MP0000266_abnormal_heart_morphology0.73325975
169* MP0002398_abnormal_bone_marrow0.72389650
170MP0003091_abnormal_cell_migration0.72313448
171MP0003948_abnormal_gas_homeostasis0.71635182
172MP0005646_abnormal_pituitary_gland0.71464076
173MP0001958_emphysema0.71226747
174MP0005375_adipose_tissue_phenotype0.70969126
175MP0000003_abnormal_adipose_tissue0.70069442
176* MP0009931_abnormal_skin_appearance0.69943325
177MP0000534_abnormal_ureter_morphology0.69712500
178MP0002269_muscular_atrophy0.69000202
179MP0000490_abnormal_crypts_of0.68136570

Predicted human phenotypes

RankGene SetZ-score
1Septo-optic dysplasia (HP:0100842)5.18170399
2Hyperventilation (HP:0002883)3.98772198
3Nasolacrimal duct obstruction (HP:0000579)3.97394727
4Partial duplication of thumb phalanx (HP:0009944)3.92535212
5Aplasia cutis congenita (HP:0001057)3.88422728
6Absent septum pellucidum (HP:0001331)3.84154028
7Abnormality of the septum pellucidum (HP:0007375)3.64666586
8Abnormality of the fingertips (HP:0001211)3.62588269
9Partial duplication of the phalanx of hand (HP:0009999)3.55742019
10Focal motor seizures (HP:0011153)3.52090224
11Fibular aplasia (HP:0002990)3.46814154
12White forelock (HP:0002211)3.39773465
13Truncus arteriosus (HP:0001660)3.35937103
14Short middle phalanx of the 5th finger (HP:0004220)3.29352847
15Abnormality of the lacrimal duct (HP:0011481)3.25529537
16Duplication of thumb phalanx (HP:0009942)3.25339715
17Polycythemia (HP:0001901)3.20755448
18Ankyloglossia (HP:0010296)3.12614316
19Chin dimple (HP:0010751)3.07239500
20Patchy hypopigmentation of hair (HP:0011365)3.07042315
21Hyperacusis (HP:0010780)3.06521589
22Acute myeloid leukemia (HP:0004808)3.05092353
23Abnormality of the nasolacrimal system (HP:0000614)3.00142903
24Chromsome breakage (HP:0040012)2.99630332
25Reticulocytosis (HP:0001923)2.97594885
26Disproportionate tall stature (HP:0001519)2.92905463
27Abnormality of the pulmonary veins (HP:0011718)2.90359322
28Long eyelashes (HP:0000527)2.88755836
29Prolonged neonatal jaundice (HP:0006579)2.88294905
30Fibular hypoplasia (HP:0003038)2.86541243
31Deep palmar crease (HP:0006191)2.83318882
32Morphological abnormality of the middle ear (HP:0008609)2.83086213
33Metabolic alkalosis (HP:0200114)2.81289225
34Aplasia/Hypoplasia of the fibula (HP:0006492)2.80965316
35Abnormality of incisor morphology (HP:0011063)2.76635344
36Aplasia/hypoplasia of the uterus (HP:0008684)2.74225450
37Aplasia involving bones of the extremities (HP:0009825)2.69963995
38Aplasia involving bones of the upper limbs (HP:0009823)2.69963995
39Aplasia of the phalanges of the hand (HP:0009802)2.69963995
40Conical tooth (HP:0000698)2.67106751
41Hyperthyroidism (HP:0000836)2.64381409
42Synostosis involving the elbow (HP:0003938)2.63828813
43Humeroradial synostosis (HP:0003041)2.63828813
44Abnormality of the phalanges of the 2nd finger (HP:0009541)2.62682248
45Anomalous pulmonary venous return (HP:0010772)2.57462118
46Short tibia (HP:0005736)2.56790948
47Abnormality of the parietal bone (HP:0002696)2.55045437
48Optic nerve hypoplasia (HP:0000609)2.51454310
49Abnormality of reticulocytes (HP:0004312)2.46047782
50Hypomagnesemia (HP:0002917)2.45129281
51Abnormality of the nasal septum (HP:0000419)2.44931685
52Dysmetric saccades (HP:0000641)2.44170834
53Abnormal gallbladder physiology (HP:0012438)2.41870243
54Cholecystitis (HP:0001082)2.41870243
55Bowel incontinence (HP:0002607)2.41335772
56Aplasia/Hypoplasia of the tibia (HP:0005772)2.39385519
57Acute lymphatic leukemia (HP:0006721)2.39178860
58Flat cornea (HP:0007720)2.38387895
59Abnormality of oral frenula (HP:0000190)2.38354126
60Atelectasis (HP:0100750)2.37003450
61Hypoplastic pelvis (HP:0008839)2.32982932
62Hypertensive crisis (HP:0100735)2.32534106
63Recurrent corneal erosions (HP:0000495)2.31683334
64Patellar dislocation (HP:0002999)2.31332658
65Urethral obstruction (HP:0000796)2.29702180
66Protrusio acetabuli (HP:0003179)2.29700527
67Short 5th finger (HP:0009237)2.27391757
68Increased nuchal translucency (HP:0010880)2.26965847
69Self-mutilation (HP:0000742)2.25707258
70Birth length less than 3rd percentile (HP:0003561)2.24590286
71Obsessive-compulsive behavior (HP:0000722)2.24224337
72Abnormality of the intervertebral disk (HP:0005108)2.22690531
73Abnormal large intestine physiology (HP:0012700)2.22524776
74Abnormality of primary teeth (HP:0006481)2.21795918
75Mixed hearing impairment (HP:0000410)2.20873019
76Fair hair (HP:0002286)2.18216848
77Insomnia (HP:0100785)2.17305399
78Aplasia/Hypoplasia of the optic nerve (HP:0008058)2.17115243
79Ectopic kidney (HP:0000086)2.15069804
80Abnormality of cochlea (HP:0000375)2.14618809
81Persistence of primary teeth (HP:0006335)2.14503854
82Premature rupture of membranes (HP:0001788)2.14280203
83J-shaped sella turcica (HP:0002680)2.12803319
84Overfolded helix (HP:0000396)2.11526509
85Concave nail (HP:0001598)2.11278928
86High anterior hairline (HP:0009890)2.10338774
87Delayed cranial suture closure (HP:0000270)2.10183374
88Broad face (HP:0000283)2.09272859
89Bladder diverticulum (HP:0000015)2.09031317
90Abnormality of chromosome segregation (HP:0002916)2.08699904
91Abnormality of the columella (HP:0009929)2.08001625
92Widely spaced teeth (HP:0000687)2.07615348
93Nonimmune hydrops fetalis (HP:0001790)2.07207266
94Sandal gap (HP:0001852)2.06706490
95Alacrima (HP:0000522)2.03664590
96Abnormal umbilical cord blood vessels (HP:0011403)2.03082532
97Single umbilical artery (HP:0001195)2.03082532
98Abnormality of the fetal cardiovascular system (HP:0010948)2.03082532
99Ileus (HP:0002595)2.01881537
100Abnormality of the tricuspid valve (HP:0001702)2.01672047
101Tubulointerstitial nephritis (HP:0001970)2.00805235
102Spinal cord compression (HP:0002176)2.00804796
103Macroorchidism (HP:0000053)1.99689007
104Supernumerary ribs (HP:0005815)1.98494097
105Aplasia/Hypoplasia of the 5th finger (HP:0006262)1.98222870
106Premature skin wrinkling (HP:0100678)1.96658696
107Hypoplasia of the iris (HP:0007676)1.96361295
108Cupped ear (HP:0000378)1.96334119
109Abnormality of calcium-phosphate metabolism (HP:0100530)1.94828051
110Aplasia/Hypoplasia involving the sinuses (HP:0009120)1.94799478
111Supernumerary spleens (HP:0009799)1.93548817
112Abnormality of the fibula (HP:0002991)1.93153039
113Polydipsia (HP:0001959)1.92684822
114Abnormal drinking behavior (HP:0030082)1.92684822
115Thin ribs (HP:0000883)1.92548531
116Exotropia (HP:0000577)1.92387653
117Abnormality of the antihelix (HP:0009738)1.92106622
118Enlarged kidneys (HP:0000105)1.90732089
119Metaphyseal cupping (HP:0003021)1.90548160
120Venous abnormality (HP:0002624)1.90096891
121Long palpebral fissure (HP:0000637)1.90050637
122Symphalangism affecting the phalanges of the hand (HP:0009773)1.89788954
123Supernumerary bones of the axial skeleton (HP:0009144)1.89323800
124Abnormality of the renal medulla (HP:0100957)1.88507448
125Agammaglobulinemia (HP:0004432)1.87932315
126Neonatal respiratory distress (HP:0002643)1.86970383
127Nephroblastoma (Wilms tumor) (HP:0002667)1.85449086
128Abnormality of the incisor (HP:0000676)1.83836290
129Embryonal renal neoplasm (HP:0011794)1.83415573
130Polyuria (HP:0000103)1.83409806
131Attention deficit hyperactivity disorder (HP:0007018)1.82732308
132Abnormally folded helix (HP:0008544)1.82341877
133Abnormality of DNA repair (HP:0003254)1.81745491
134Preaxial foot polydactyly (HP:0001841)1.81002427
135Spinal rigidity (HP:0003306)1.80826813
136Squamous cell carcinoma (HP:0002860)1.80663985
137Decreased lacrimation (HP:0000633)1.80325831
138Chromosomal breakage induced by crosslinking agents (HP:0003221)1.79315403
139Aplasia/Hypoplasia of the earlobes (HP:0009906)1.79038812
140Hypophosphatemic rickets (HP:0004912)1.78265947
141Broad palm (HP:0001169)1.77719184
142Aplasia/hypoplasia of the femur (HP:0005613)1.77085107
143Abnormal sex determination (HP:0012244)1.76997059
144Sex reversal (HP:0012245)1.76997059
145Duplicated collecting system (HP:0000081)1.76254279
146Metaphyseal dysplasia (HP:0100255)1.76224121
147Myelodysplasia (HP:0002863)1.76212148
148Pointed chin (HP:0000307)1.76024500
149Cafe-au-lait spot (HP:0000957)1.75814061
150Abnormality of the renal collecting system (HP:0004742)1.75640293
151Pulmonary artery stenosis (HP:0004415)1.75602697
152Overlapping toe (HP:0001845)1.75593793
153Spontaneous hematomas (HP:0007420)1.74622844
154Absent frontal sinuses (HP:0002688)1.74473859
155Centrally nucleated skeletal muscle fibers (HP:0003687)1.74414111
156Narrow palate (HP:0000189)1.74201603
157Renal duplication (HP:0000075)1.74001116
158Aortic aneurysm (HP:0004942)1.73810121
159Absent speech (HP:0001344)1.73505999
160Abnormality of the calcaneus (HP:0008364)1.72783402
161Anal stenosis (HP:0002025)1.72400981
162Neonatal short-limb short stature (HP:0008921)1.72355447
163Abnormal number of incisors (HP:0011064)1.72324534
164Genetic anticipation (HP:0003743)1.71913764
165Short femoral neck (HP:0100864)1.71835363
166Progressive muscle weakness (HP:0003323)1.71524867
167Xerostomia (HP:0000217)1.71372708
168Venous insufficiency (HP:0005293)1.71221031
169Craniofacial hyperostosis (HP:0004493)1.70491138
170Osteomalacia (HP:0002749)1.70404574
171Increased connective tissue (HP:0009025)1.69580679
172Renovascular hypertension (HP:0100817)1.69519917
173Increased circulating renin level (HP:0000848)1.69111357
174Arteriovenous malformation (HP:0100026)1.68938827
175Relative macrocephaly (HP:0004482)1.68670050
176Absent/shortened dynein arms (HP:0200106)1.68223627
177Dynein arm defect of respiratory motile cilia (HP:0012255)1.68223627
178Hypoparathyroidism (HP:0000829)1.67780577
179Elfin facies (HP:0004428)1.67606533
180Aplasia/Hypoplasia of the phalanges of the toes (HP:0010173)1.67360844
181Aplasia/Hypoplasia involving the femoral head and neck (HP:0009108)1.67195971
182Obstructive sleep apnea (HP:0002870)1.66754759
183Syringomyelia (HP:0003396)1.66266384
184Spinal cord lesions (HP:0100561)1.66266384
185Dilatation of the ascending aorta (HP:0005111)1.65700219
186Cerebral aneurysm (HP:0004944)1.65248138
187Intestinal malrotation (HP:0002566)1.63587284
188Facial hemangioma (HP:0000329)1.62995576
189Asymmetry of the thorax (HP:0001555)1.62916343
190Overriding aorta (HP:0002623)1.61322596
191Ulnar bowing (HP:0003031)1.61075289
192Dislocated radial head (HP:0003083)1.60856528
193Spondylolisthesis (HP:0003302)1.60359134

Predicted kinase interactions (KEA)

RankGene SetZ-score
1BLK6.21788346
2TRIB35.14611841
3MKNK25.00160460
4CASK4.22360811
5EEF2K3.78670853
6MAP3K133.54219418
7ICK3.34612108
8MKNK13.16132923
9SMG12.51156436
10ADRBK22.26033841
11EPHA32.24618524
12MAP3K102.13960440
13CDC72.04414329
14NTRK32.00811310
15NEK22.00456403
16PKN11.87641652
17KSR21.79089995
18MAP3K141.76635389
19SIK21.73190697
20FGR1.67753955
21MTOR1.66341752
22EPHA41.64385120
23PRPF4B1.61867110
24FES1.60649613
25INSRR1.60314580
26EIF2AK11.59648646
27YES11.57857097
28TTK1.57773800
29GRK71.56563190
30CLK11.56524914
31CAMK1G1.51223806
32CHEK21.46045507
33CDK121.45243810
34PKN21.42394076
35LATS21.36844172
36RIPK41.35885082
37GRK61.35648615
38TGFBR21.33717441
39MAP3K81.31441968
40TNK21.25726009
41RPS6KB21.24622737
42NME21.23335989
43CAMK1D1.22712858
44IRAK31.19537036
45KSR11.19439826
46GRK51.18902536
47CHEK11.17162937
48STK391.14749992
49ATR1.14321403
50ERN11.13561888
51GRK11.12870658
52PLK41.11999018
53NME11.09945704
54IRAK11.09181234
55TRPM71.07857891
56PAK21.07531974
57MAP2K71.06179927
58SIK11.05771641
59OXSR11.05704105
60WNK41.04482825
61RAF11.02249105
62LATS11.00668914
63MAPK130.99864846
64STK100.98184609
65MAP3K70.96997197
66EPHB20.96049748
67CDK40.95080454
68SIK30.94421425
69CSK0.94275798
70PDGFRA0.93884894
71CDK70.92968707
72TIE10.90223476
73MAP3K20.90072932
74MELK0.89896980
75STK40.89605731
76BUB10.88555309
77ADRBK10.87128095
78MAP2K40.85442396
79WNK10.85116273
80PIK3CA0.84017876
81MAP3K60.83228690
82FER0.80284585
83PLK20.78776272
84DMPK0.78603135
85TNIK0.78303199
86BRAF0.78269974
87BMPR20.77885969
88MAPK110.76824559
89CDK20.75274309
90PRKCQ0.73295357
91IRAK40.72369249
92MARK20.72195219
93ILK0.71864587
94CDK10.70565551
95SCYL20.69820739
96ROCK20.69575196
97EIF2AK20.69396713
98BTK0.67635465
99EPHB10.67600500
100NEK90.67302660
101TLK10.66686007
102KIT0.65441709
103RET0.64796773
104AURKB0.63911256
105ATM0.63554004
106BRD40.63407689
107STK30.63259347
108DYRK1A0.61613084
109WEE10.61574231
110CDK30.61044117
111PRKCE0.60530511
112BMX0.59621876
113IRAK20.58731756
114CDK90.58420573
115ALK0.57578176
116MARK30.57444419
117TTN0.56592645
118MAP3K40.56459700
119FGFR30.56154124
120CDC42BPA0.55465229
121PAK30.53681228
122TEC0.51743120
123MAP2K30.51686113
124CCNB10.51647743
125TAOK30.50421578
126CDK80.50401315
127AKT30.50374430
128MUSK0.50203927
129PTK60.49827137
130MAP3K10.49795509
131HIPK20.48804868
132LYN0.48432931
133PRKD20.46327093
134MOS0.44700081
135FGFR40.44237044
136JAK30.42924746
137AKT20.42726531
138UHMK10.42704811
139ZAK0.42432621
140NTRK20.42153373
141AKT10.41941058
142MATK0.40857576
143PAK10.40816620
144BRSK10.40662164
145PRKAA20.40621430
146CSNK1A1L0.40372272
147RPS6KL10.40177491
148RPS6KC10.40177491
149AURKA0.40111347
150NEK60.39952631
151FYN0.39829381
152MAPK10.38720017
153PAK40.38043553
154MAPK140.37777151
155MAPKAPK50.37745093
156CAMK10.37543293
157MST1R0.37411065
158HCK0.37187720
159PNCK0.36987382
160WNK30.36048023
161STK160.35743332
162NUAK10.35020762
163CAMK2A0.34830191
164MAPK120.34544585
165PRKACA0.34234219
166PAK60.34069165
167MAPK70.33989168
168TXK0.32805228
169SRC0.31609089
170CSF1R0.30983232
171PTK2B0.30971733
172PRKG10.30528492
173BMPR1B0.30437725
174INSR0.30204708
175PTK20.29317595

Predicted pathways (KEGG)

RankGene SetZ-score
1Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006033.66614946
2Nicotine addiction_Homo sapiens_hsa050333.08248893
3DNA replication_Homo sapiens_hsa030302.74946967
4Chronic myeloid leukemia_Homo sapiens_hsa052202.73793218
5Synthesis and degradation of ketone bodies_Homo sapiens_hsa000722.71504773
6Taurine and hypotaurine metabolism_Homo sapiens_hsa004302.34678343
7Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa009702.26764054
8Cell cycle_Homo sapiens_hsa041102.20272486
9Acute myeloid leukemia_Homo sapiens_hsa052212.16022555
10Pancreatic cancer_Homo sapiens_hsa052122.14856412
11Neuroactive ligand-receptor interaction_Homo sapiens_hsa040802.11497966
12Retrograde endocannabinoid signaling_Homo sapiens_hsa047232.08672152
13Cell adhesion molecules (CAMs)_Homo sapiens_hsa045142.03641961
14Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005122.02222894
15Glutamatergic synapse_Homo sapiens_hsa047242.01862750
16Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030081.99014469
17mRNA surveillance pathway_Homo sapiens_hsa030151.98882843
18Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006011.93810023
19Non-small cell lung cancer_Homo sapiens_hsa052231.93546787
20One carbon pool by folate_Homo sapiens_hsa006701.82766136
21Axon guidance_Homo sapiens_hsa043601.81226206
22Spliceosome_Homo sapiens_hsa030401.81226135
23Taste transduction_Homo sapiens_hsa047421.78787852
24Systemic lupus erythematosus_Homo sapiens_hsa053221.77120068
25Thyroid cancer_Homo sapiens_hsa052161.77020872
26Morphine addiction_Homo sapiens_hsa050321.69837773
27Viral carcinogenesis_Homo sapiens_hsa052031.69628516
28Butirosin and neomycin biosynthesis_Homo sapiens_hsa005241.68254250
29MicroRNAs in cancer_Homo sapiens_hsa052061.66432287
30RNA transport_Homo sapiens_hsa030131.65011468
31Serotonergic synapse_Homo sapiens_hsa047261.63048845
32Long-term depression_Homo sapiens_hsa047301.60687848
33Salivary secretion_Homo sapiens_hsa049701.59885187
34Bladder cancer_Homo sapiens_hsa052191.55702698
35mTOR signaling pathway_Homo sapiens_hsa041501.52828539
36Alcoholism_Homo sapiens_hsa050341.51180800
37Mismatch repair_Homo sapiens_hsa034301.47621663
38Lysine degradation_Homo sapiens_hsa003101.47416691
39Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa005341.47338757
40Melanoma_Homo sapiens_hsa052181.46994464
41GABAergic synapse_Homo sapiens_hsa047271.46479849
42Glioma_Homo sapiens_hsa052141.45867699
43Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate_Homo sapiens_hsa005321.45612551
44Staphylococcus aureus infection_Homo sapiens_hsa051501.41549717
45ErbB signaling pathway_Homo sapiens_hsa040121.35465362
46Prostate cancer_Homo sapiens_hsa052151.35365178
47Colorectal cancer_Homo sapiens_hsa052101.34454112
48Renin secretion_Homo sapiens_hsa049241.33697302
49Progesterone-mediated oocyte maturation_Homo sapiens_hsa049141.33334944
50Renal cell carcinoma_Homo sapiens_hsa052111.32999103
51Nucleotide excision repair_Homo sapiens_hsa034201.32649226
52Homologous recombination_Homo sapiens_hsa034401.29695424
53Hepatitis B_Homo sapiens_hsa051611.26635571
54Small cell lung cancer_Homo sapiens_hsa052221.25835615
55VEGF signaling pathway_Homo sapiens_hsa043701.21794331
56Central carbon metabolism in cancer_Homo sapiens_hsa052301.20776249
57Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005331.17698207
58Fanconi anemia pathway_Homo sapiens_hsa034601.17576119
59Endometrial cancer_Homo sapiens_hsa052131.16025062
60Neurotrophin signaling pathway_Homo sapiens_hsa047221.15602044
61Arrhythmogenic right ventricular cardiomyopathy (ARVC)_Homo sapiens_hsa054121.15315791
62Hedgehog signaling pathway_Homo sapiens_hsa043401.13310775
63Regulation of lipolysis in adipocytes_Homo sapiens_hsa049231.13007833
64Basal cell carcinoma_Homo sapiens_hsa052171.12459875
65Calcium signaling pathway_Homo sapiens_hsa040201.12243902
66Ras signaling pathway_Homo sapiens_hsa040141.11634216
67Prolactin signaling pathway_Homo sapiens_hsa049171.10427471
68Rap1 signaling pathway_Homo sapiens_hsa040151.10417799
69Longevity regulating pathway - multiple species_Homo sapiens_hsa042131.10077165
70Arachidonic acid metabolism_Homo sapiens_hsa005901.09625876
71Malaria_Homo sapiens_hsa051441.08681415
72HTLV-I infection_Homo sapiens_hsa051661.08663815
73Base excision repair_Homo sapiens_hsa034101.08350265
74Regulation of actin cytoskeleton_Homo sapiens_hsa048101.08161218
75Fatty acid elongation_Homo sapiens_hsa000621.07841794
76Phospholipase D signaling pathway_Homo sapiens_hsa040721.07833365
77Protein processing in endoplasmic reticulum_Homo sapiens_hsa041411.07076742
78African trypanosomiasis_Homo sapiens_hsa051431.03757161
79Glycosaminoglycan degradation_Homo sapiens_hsa005311.03710808
80Type II diabetes mellitus_Homo sapiens_hsa049301.02051690
81Herpes simplex infection_Homo sapiens_hsa051681.01390623
82Thyroid hormone signaling pathway_Homo sapiens_hsa049190.99567755
83Ether lipid metabolism_Homo sapiens_hsa005650.99437092
84Dilated cardiomyopathy_Homo sapiens_hsa054140.99329284
85Phototransduction_Homo sapiens_hsa047440.98818077
86Fc epsilon RI signaling pathway_Homo sapiens_hsa046640.98723276
87ECM-receptor interaction_Homo sapiens_hsa045120.98437540
88Ubiquitin mediated proteolysis_Homo sapiens_hsa041200.98297134
89Hypertrophic cardiomyopathy (HCM)_Homo sapiens_hsa054100.95953052
90Epstein-Barr virus infection_Homo sapiens_hsa051690.95861767
91Notch signaling pathway_Homo sapiens_hsa043300.94625809
92Apoptosis_Homo sapiens_hsa042100.94522689
93Adherens junction_Homo sapiens_hsa045200.94381779
94Sphingolipid metabolism_Homo sapiens_hsa006000.94117782
95Non-homologous end-joining_Homo sapiens_hsa034500.94036319
96B cell receptor signaling pathway_Homo sapiens_hsa046620.93210032
97Circadian entrainment_Homo sapiens_hsa047130.92586886
98Longevity regulating pathway - mammal_Homo sapiens_hsa042110.91977034
99cAMP signaling pathway_Homo sapiens_hsa040240.90889529
100Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010400.89088217
101Insulin signaling pathway_Homo sapiens_hsa049100.87960188
102Cytokine-cytokine receptor interaction_Homo sapiens_hsa040600.87586483
103Proteoglycans in cancer_Homo sapiens_hsa052050.86838004
104Influenza A_Homo sapiens_hsa051640.85869710
105Oxytocin signaling pathway_Homo sapiens_hsa049210.85553956
106p53 signaling pathway_Homo sapiens_hsa041150.85530769
107Measles_Homo sapiens_hsa051620.85065494
108Melanogenesis_Homo sapiens_hsa049160.83748239
109MAPK signaling pathway_Homo sapiens_hsa040100.82799054
110Long-term potentiation_Homo sapiens_hsa047200.82023112
111Wnt signaling pathway_Homo sapiens_hsa043100.81920626
112Terpenoid backbone biosynthesis_Homo sapiens_hsa009000.81334373
113Ovarian steroidogenesis_Homo sapiens_hsa049130.79607320
114Vascular smooth muscle contraction_Homo sapiens_hsa042700.76613023
115HIF-1 signaling pathway_Homo sapiens_hsa040660.76345850
116Transcriptional misregulation in cancer_Homo sapiens_hsa052020.75816881
117Basal transcription factors_Homo sapiens_hsa030220.73889701
118Other glycan degradation_Homo sapiens_hsa005110.73226574
119Other types of O-glycan biosynthesis_Homo sapiens_hsa005140.73191816
120Choline metabolism in cancer_Homo sapiens_hsa052310.72795799
121cGMP-PKG signaling pathway_Homo sapiens_hsa040220.70452984
122Inflammatory bowel disease (IBD)_Homo sapiens_hsa053210.69186665
123Osteoclast differentiation_Homo sapiens_hsa043800.69030957
124Leukocyte transendothelial migration_Homo sapiens_hsa046700.68967665
125Phagosome_Homo sapiens_hsa041450.66348314
126RIG-I-like receptor signaling pathway_Homo sapiens_hsa046220.66019077
127Gastric acid secretion_Homo sapiens_hsa049710.65823512
128PI3K-Akt signaling pathway_Homo sapiens_hsa041510.65427922
129AMPK signaling pathway_Homo sapiens_hsa041520.63838175
130Hematopoietic cell lineage_Homo sapiens_hsa046400.63752810
131FoxO signaling pathway_Homo sapiens_hsa040680.63617182
132Estrogen signaling pathway_Homo sapiens_hsa049150.63459808
133Inositol phosphate metabolism_Homo sapiens_hsa005620.62315992
134Dorso-ventral axis formation_Homo sapiens_hsa043200.61926587
135Steroid biosynthesis_Homo sapiens_hsa001000.61148341
136Pathways in cancer_Homo sapiens_hsa052000.60756744
137Pancreatic secretion_Homo sapiens_hsa049720.60534578
138Gap junction_Homo sapiens_hsa045400.58904030
139Chemokine signaling pathway_Homo sapiens_hsa040620.56807950
140Bacterial invasion of epithelial cells_Homo sapiens_hsa051000.56717167
141Dopaminergic synapse_Homo sapiens_hsa047280.56472392
142Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa051200.56458149
143Pyrimidine metabolism_Homo sapiens_hsa002400.56432813
144Shigellosis_Homo sapiens_hsa051310.55933158
145Pentose phosphate pathway_Homo sapiens_hsa000300.55924519
146Oocyte meiosis_Homo sapiens_hsa041140.55609647
147Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006040.54809083
148T cell receptor signaling pathway_Homo sapiens_hsa046600.54159588
149Alzheimers disease_Homo sapiens_hsa050100.53854801
150Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa045500.53304842
151Platelet activation_Homo sapiens_hsa046110.53275455
152TNF signaling pathway_Homo sapiens_hsa046680.52876641
153Rheumatoid arthritis_Homo sapiens_hsa053230.52430824
154Hepatitis C_Homo sapiens_hsa051600.51678681
155Adrenergic signaling in cardiomyocytes_Homo sapiens_hsa042610.51658312
156Pentose and glucuronate interconversions_Homo sapiens_hsa000400.50415939
157Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa047500.48596347
158NF-kappa B signaling pathway_Homo sapiens_hsa040640.48351635
159Phosphatidylinositol signaling system_Homo sapiens_hsa040700.47784546
160Cholinergic synapse_Homo sapiens_hsa047250.47616347
161Toll-like receptor signaling pathway_Homo sapiens_hsa046200.47164976
162Autoimmune thyroid disease_Homo sapiens_hsa053200.46910261
163AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa049330.46794793
164Citrate cycle (TCA cycle)_Homo sapiens_hsa000200.46554702
165Intestinal immune network for IgA production_Homo sapiens_hsa046720.46302117
166Insulin resistance_Homo sapiens_hsa049310.45955322
167Leishmaniasis_Homo sapiens_hsa051400.45940818
168Complement and coagulation cascades_Homo sapiens_hsa046100.45870539
169Fc gamma R-mediated phagocytosis_Homo sapiens_hsa046660.45554029
170Jak-STAT signaling pathway_Homo sapiens_hsa046300.45531419
171Aldosterone synthesis and secretion_Homo sapiens_hsa049250.45336321
172Fatty acid biosynthesis_Homo sapiens_hsa000610.45010043
173Adipocytokine signaling pathway_Homo sapiens_hsa049200.44227578
174Sphingolipid signaling pathway_Homo sapiens_hsa040710.44127714
175Mineral absorption_Homo sapiens_hsa049780.43266197
176Tuberculosis_Homo sapiens_hsa051520.42877568
177Focal adhesion_Homo sapiens_hsa045100.41550360
178Oxidative phosphorylation_Homo sapiens_hsa001900.41289577
179Insulin secretion_Homo sapiens_hsa049110.39865031

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