HOXB7

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: This gene is a member of the Antp homeobox family and encodes a protein with a homeobox DNA-binding domain. It is included in a cluster of homeobox B genes located on chromosome 17. The encoded nuclear protein functions as a sequence-specific transcription factor that is involved in cell proliferation and differentiation. Increased expression of this gene is associated with some cases of melanoma and ovarian carcinoma. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1DNA deamination (GO:0045006)9.41991989
2regulation of hydrogen peroxide metabolic process (GO:0010310)7.49142696
3exogenous drug catabolic process (GO:0042738)6.41695803
4pteridine-containing compound biosynthetic process (GO:0042559)5.52764995
5flavonoid metabolic process (GO:0009812)5.50384879
6drug catabolic process (GO:0042737)5.41172313
7regulation of respiratory burst (GO:0060263)5.13248078
8negative regulation of keratinocyte proliferation (GO:0010839)4.74379422
9ribosomal large subunit biogenesis (GO:0042273)4.68972924
10heterochromatin organization (GO:0070828)4.59823841
11chondrocyte proliferation (GO:0035988)4.26708199
12regulation of apoptotic process involved in morphogenesis (GO:1902337)4.25356474
13glutathione biosynthetic process (GO:0006750)4.14497636
14nonribosomal peptide biosynthetic process (GO:0019184)4.13815026
15regulation of mitochondrial translation (GO:0070129)4.03123126
16lung vasculature development (GO:0060426)3.97090018
17proteasome assembly (GO:0043248)3.96973687
18nucleoside salvage (GO:0043174)3.94713275
19sulfation (GO:0051923)3.85728929
20calcium-independent cell-cell adhesion via plasma membrane cell-adhesion molecules (GO:0016338)3.83082683
21mesenchymal to epithelial transition involved in metanephros morphogenesis (GO:0003337)3.81890841
22lung morphogenesis (GO:0060425)3.74860016
23proximal/distal pattern formation (GO:0009954)3.71997095
24nucleobase-containing small molecule interconversion (GO:0015949)3.69970854
25melanin biosynthetic process (GO:0042438)3.67157391
26body morphogenesis (GO:0010171)3.62343760
273-phosphoadenosine 5-phosphosulfate metabolic process (GO:0050427)3.58284563
28purine ribonucleoside bisphosphate metabolic process (GO:0034035)3.58284563
29blood vessel endothelial cell migration (GO:0043534)3.53596256
30ribosomal small subunit biogenesis (GO:0042274)3.52451055
31renal absorption (GO:0070293)3.52446063
32glycine transport (GO:0015816)3.52013051
33drug transport (GO:0015893)3.46637050
34CTP metabolic process (GO:0046036)3.44221849
35CTP biosynthetic process (GO:0006241)3.44221849
36negative regulation of metanephros development (GO:0072217)3.43207790
37negative regulation of DNA biosynthetic process (GO:2000279)3.40033853
38mesenchymal cell differentiation involved in kidney development (GO:0072161)3.37972970
39mesenchymal cell differentiation involved in renal system development (GO:2001012)3.37972970
40pyrimidine nucleoside triphosphate biosynthetic process (GO:0009148)3.37881273
41pattern specification involved in kidney development (GO:0061004)3.34372216
42kidney mesenchyme development (GO:0072074)3.32816690
43ribosome biogenesis (GO:0042254)3.32622835
44viral transcription (GO:0019083)3.30682887
45pyrimidine ribonucleoside triphosphate biosynthetic process (GO:0009209)3.30043694
46lymph vessel development (GO:0001945)3.28824974
47translational termination (GO:0006415)3.28591581
48pyrimidine-containing compound salvage (GO:0008655)3.27836640
49pyrimidine nucleoside salvage (GO:0043097)3.27836640
50ribonucleoprotein complex biogenesis (GO:0022613)3.27823631
51metanephric mesenchyme development (GO:0072075)3.26437965
52cell migration involved in sprouting angiogenesis (GO:0002042)3.26054662
53establishment of protein localization to mitochondrial membrane (GO:0090151)3.23558138
54white fat cell differentiation (GO:0050872)3.20197878
55metanephric epithelium development (GO:0072207)3.16148780
56NADPH regeneration (GO:0006740)3.14364314
57translational elongation (GO:0006414)3.08855332
58pentose-phosphate shunt (GO:0006098)3.07755676
59metanephric tubule development (GO:0072170)3.04638607
60metanephric nephron tubule development (GO:0072234)3.04638607
61regulation of translational termination (GO:0006449)3.04167187
62melanin metabolic process (GO:0006582)3.03126637
63response to vitamin A (GO:0033189)3.02755864
64secondary metabolite biosynthetic process (GO:0044550)3.02435558
65leukotriene biosynthetic process (GO:0019370)3.01789133
66DNA damage response, detection of DNA damage (GO:0042769)3.00454816
67pyrimidine ribonucleoside triphosphate metabolic process (GO:0009208)2.99703860
68pyrimidine nucleoside triphosphate metabolic process (GO:0009147)2.97963061
69kinetochore assembly (GO:0051382)2.96492780
70nucleotide salvage (GO:0043173)2.95341811
71endothelial cell morphogenesis (GO:0001886)2.94621805
72drug transmembrane transport (GO:0006855)2.94333090
73peptide biosynthetic process (GO:0043043)2.92429945
74regulation of cellular respiration (GO:0043457)2.92279898
75embryonic body morphogenesis (GO:0010172)2.91182015
76mesenchymal to epithelial transition (GO:0060231)2.90780040
77mitochondrial ATP synthesis coupled proton transport (GO:0042776)2.90453966
78cellular ketone body metabolic process (GO:0046950)2.89393901
79anterior/posterior axis specification, embryo (GO:0008595)2.88524378
80SRP-dependent cotranslational protein targeting to membrane (GO:0006614)2.87937198
81formation of translation preinitiation complex (GO:0001731)2.87714865
82metanephric nephron epithelium development (GO:0072243)2.86830222
83ribosome assembly (GO:0042255)2.85787893
84cellular response to vitamin D (GO:0071305)2.84481395
85sulfur amino acid catabolic process (GO:0000098)2.84164952
86mitochondrial electron transport, NADH to ubiquinone (GO:0006120)2.84147797
87excretion (GO:0007588)2.84026063
88protein targeting to ER (GO:0045047)2.82124011
89translation (GO:0006412)2.81766471
90embryonic skeletal joint morphogenesis (GO:0060272)2.81731264
91nephron tubule formation (GO:0072079)2.80637035
92cotranslational protein targeting to membrane (GO:0006613)2.80411632
93aminoglycoside antibiotic metabolic process (GO:0030647)2.80054438
94piRNA metabolic process (GO:0034587)2.77706260
95DNA replication checkpoint (GO:0000076)2.77503530
96maternal placenta development (GO:0001893)2.74043386
97protein localization to endoplasmic reticulum (GO:0070972)2.73928547
98sulfate transmembrane transport (GO:1902358)2.73067903
99cellular protein complex disassembly (GO:0043624)2.72873901
100negative regulation of telomerase activity (GO:0051974)2.71078817
101vascular endothelial growth factor receptor signaling pathway (GO:0048010)2.70636057
102kinetochore organization (GO:0051383)2.69579133
103establishment of protein localization to endoplasmic reticulum (GO:0072599)2.69078981
104sulfate transport (GO:0008272)2.68869464
105myeloid cell homeostasis (GO:0002262)2.67971229
106regulation of hippo signaling (GO:0035330)2.67778412
107regulation of cellular amino acid metabolic process (GO:0006521)2.66638773
108negative regulation of DNA repair (GO:0045738)2.66562810
109nephron tubule development (GO:0072080)2.65829495
110cellular response to vitamin (GO:0071295)2.65689734
111telomere maintenance via semi-conservative replication (GO:0032201)2.65331486
112cellular component biogenesis (GO:0044085)2.65317771
113diterpenoid biosynthetic process (GO:0016102)2.64491044
114organ induction (GO:0001759)2.63341259
115positive regulation of vascular permeability (GO:0043117)2.62856986
116actin filament depolymerization (GO:0030042)2.62368788
117axon extension involved in axon guidance (GO:0048846)2.61956833
118neuron projection extension involved in neuron projection guidance (GO:1902284)2.61956833
119collecting duct development (GO:0072044)2.61797352
120cell migration involved in heart development (GO:0060973)2.61097889
121basement membrane organization (GO:0071711)2.59385133
122outer ear morphogenesis (GO:0042473)2.59330635
123pyrimidine ribonucleoside monophosphate biosynthetic process (GO:0009174)2.59010511
124UMP metabolic process (GO:0046049)2.59010511
125pyrimidine ribonucleoside monophosphate metabolic process (GO:0009173)2.59010511
126UMP biosynthetic process (GO:0006222)2.59010511
127extracellular matrix assembly (GO:0085029)2.57190511
128embryonic digestive tract development (GO:0048566)2.56919783
129energy coupled proton transport, down electrochemical gradient (GO:0015985)2.55979957
130ATP synthesis coupled proton transport (GO:0015986)2.55979957
131nephron tubule morphogenesis (GO:0072078)2.55950201
132nephron epithelium morphogenesis (GO:0072088)2.55950201
133protein complex disassembly (GO:0043241)2.55120710
134negative regulation of stem cell proliferation (GO:2000647)2.54928167
135L-methionine biosynthetic process from methylthioadenosine (GO:0019509)2.54597187
136pteridine-containing compound metabolic process (GO:0042558)2.54480901
137translational initiation (GO:0006413)2.53895499
138negative regulation of chondrocyte differentiation (GO:0032331)2.53597000
139antibacterial humoral response (GO:0019731)2.53090501
140fructose metabolic process (GO:0006000)2.53032689
141transcription from mitochondrial promoter (GO:0006390)2.52882590
142ketone body metabolic process (GO:1902224)2.51783652
143pyrimidine nucleoside monophosphate biosynthetic process (GO:0009130)2.51765492
144positive regulation of chondrocyte differentiation (GO:0032332)2.51252677
145cysteine metabolic process (GO:0006534)2.51163528
146establishment or maintenance of epithelial cell apical/basal polarity (GO:0045197)2.50926642
147pyrimidine nucleoside monophosphate metabolic process (GO:0009129)2.50767826
148urate metabolic process (GO:0046415)2.50678687
149respiratory chain complex IV assembly (GO:0008535)2.50323993
150desmosome organization (GO:0002934)2.50250967
151negative regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051436)2.50148123
152anaphase-promoting complex-dependent proteasomal ubiquitin-dependent protein catabolic process (GO:02.50135965
153vascular endothelial growth factor signaling pathway (GO:0038084)2.50117804
154viral life cycle (GO:0019058)2.49976933
155negative regulation of ubiquitin-protein transferase activity (GO:0051444)2.49867173
156negative regulation of ligase activity (GO:0051352)2.49867173
157negative regulation of homotypic cell-cell adhesion (GO:0034111)2.49749425
158positive regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051437)2.48664410
159pentose metabolic process (GO:0019321)2.46744649
160pyrimidine ribonucleoside biosynthetic process (GO:0046132)2.46021355
161ribonucleoprotein complex disassembly (GO:0032988)2.45879176
162GTP biosynthetic process (GO:0006183)2.45778232
163synapsis (GO:0007129)2.45123549
164rRNA metabolic process (GO:0016072)2.43619631
165rRNA processing (GO:0006364)2.42756622
166protein targeting to mitochondrion (GO:0006626)2.42551670
167pseudouridine synthesis (GO:0001522)2.41904622
168regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051439)2.41196291
169rRNA catabolic process (GO:0016075)2.39718279
170behavioral response to nicotine (GO:0035095)2.39670196
171establishment of protein localization to mitochondrion (GO:0072655)2.38147949
172GDP-mannose metabolic process (GO:0019673)2.37296424
173* embryonic skeletal system morphogenesis (GO:0048704)2.37165753
174positive regulation of ubiquitin-protein transferase activity (GO:0051443)2.37028945
175respiratory electron transport chain (GO:0022904)2.36775220
176RNA splicing, via endonucleolytic cleavage and ligation (GO:0000394)2.36328410
177tRNA splicing, via endonucleolytic cleavage and ligation (GO:0006388)2.36328410
178maturation of SSU-rRNA (GO:0030490)2.35707305
179chromosome organization involved in meiosis (GO:0070192)2.35633142
180regulation of transcription involved in G1/S transition of mitotic cell cycle (GO:0000083)2.35278662
181electron transport chain (GO:0022900)2.34729677
182UTP biosynthetic process (GO:0006228)2.33719527
183quinone metabolic process (GO:1901661)2.33415972
184AMP metabolic process (GO:0046033)2.31358522
185iron-sulfur cluster assembly (GO:0016226)2.30829842
186metallo-sulfur cluster assembly (GO:0031163)2.30829842
187peptidyl-histidine modification (GO:0018202)2.30449295
188guanosine-containing compound biosynthetic process (GO:1901070)2.29085590
189pyrimidine ribonucleotide biosynthetic process (GO:0009220)2.28062149

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1TP63_17297297_ChIP-ChIP_HaCaT_Human6.00736138
2PPARG_19300518_ChIP-PET_3T3-L1_Mouse4.33575337
3KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human3.95791773
4TRIM28_21343339_ChIP-Seq_HEK293_Human3.84744004
5JARID1A_20064375_ChIP-Seq_MESCs_Mouse3.76747285
6GABP_17652178_ChIP-ChIP_JURKAT_Human3.67605921
7CHD7_19251738_ChIP-ChIP_MESCs_Mouse3.56024002
8TRP63_18441228_ChIP-ChIP_KERATINOCYTES_Mouse3.32687503
9ETS1_20019798_ChIP-Seq_JURKAT_Human3.13881607
10E2F7_22180533_ChIP-Seq_HELA_Human2.95590043
11RARG_19884340_ChIP-ChIP_MEFs_Mouse2.86175115
12HCFC1_20581084_ChIP-Seq_MESCs_Mouse2.84116943
13TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat2.76538143
14MYC_18358816_ChIP-ChIP_MESCs_Mouse2.74394638
15FOXM1_25889361_ChIP-Seq_OE33_AND_U2OS_Human2.70459607
16CDX2_20551321_ChIP-Seq_CACO-2_Human2.67117230
17FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse2.45946959
18DCP1A_22483619_ChIP-Seq_HELA_Human2.41330122
19MYBL1_21750041_ChIP-ChIP_SPERMATOCYTES_Mouse2.38364882
20CREB1_15753290_ChIP-ChIP_HEK293T_Human2.33420437
21NANOG_18700969_ChIP-ChIP_MESCs_Mouse2.32704881
22CLOCK_20551151_ChIP-Seq_293T_Human2.31715362
23XRN2_22483619_ChIP-Seq_HELA_Human2.30634335
24KLF5_18264089_ChIP-ChIP_MESCs_Mouse2.28703835
25KLF4_18264089_ChIP-ChIP_MESCs_Mouse2.28703835
26KLF2_18264089_ChIP-ChIP_MESCs_Mouse2.28703835
27MYC_19079543_ChIP-ChIP_MESCs_Mouse2.27715234
28EST1_17652178_ChIP-ChIP_JURKAT_Human2.27380236
29SMAD4_19686287_ChIP-ChIP_HaCaT_Human2.22691117
30MYC_19030024_ChIP-ChIP_MESCs_Mouse2.19204586
31ZNF263_19887448_ChIP-Seq_K562_Human2.11882192
32STAT3_22323479_ChIP-Seq_MACROPHAGE_Mouse2.11355045
33GABP_19822575_ChIP-Seq_HepG2_Human2.09244342
34THAP11_20581084_ChIP-Seq_MESCs_Mouse2.08359853
35ESR2_21235772_ChIP-Seq_MCF-7_Human2.07798429
36ZFP281_18358816_ChIP-ChIP_MESCs_Mouse2.07387415
37TTF2_22483619_ChIP-Seq_HELA_Human2.05590198
38HIF1A_21447827_ChIP-Seq_MCF-7_Human2.01986761
39POU5F1_18700969_ChIP-ChIP_MESCs_Mouse2.00541483
40ELK3_25401928_ChIP-Seq_HUVEC_Human1.94718661
41PDX1_19855005_ChIP-ChIP_MIN6_Mouse1.94567661
42STAT6_21828071_ChIP-Seq_BEAS2B_Human1.92392744
43WT1_20215353_ChIP-ChIP_NEPHRON_PROGENITOR_Mouse1.92082240
44E2F1_18555785_ChIP-Seq_MESCs_Mouse1.90451476
45* KLF4_18358816_ChIP-ChIP_MESCs_Mouse1.87421639
46ELK1_19687146_ChIP-ChIP_HELA_Human1.83025574
47PPARG_23326641_ChIP-Seq_C3H10T1-2_Mouse1.82993153
48SRF_21415370_ChIP-Seq_HL-1_Mouse1.82944594
49ESR1_21235772_ChIP-Seq_MCF-7_Human1.82291596
50CHD1_19587682_ChIP-ChIP_MESCs_Mouse1.80287276
51ESR1_17901129_ChIP-ChIP_LIVER_Mouse1.77361893
52KLF4_26769127_Chip-Seq_PDAC-Cell_line_Human1.75980186
53DACH1_20351289_ChIP-Seq_MDA-MB-231_Human1.75408894
54RUNX2_24764292_ChIP-Seq_MC3T3_Mouse1.75273578
55RACK7_27058665_Chip-Seq_MCF-7_Human1.73640694
56NOTCH1_17114293_ChIP-ChIP_T-ALL_Human1.70119416
57HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human1.69208243
58SRY_22984422_ChIP-ChIP_TESTIS_Rat1.68774866
59KLF6_26769127_Chip-Seq_PDAC-Cell_line_Human1.66788023
60E2F4_17652178_ChIP-ChIP_JURKAT_Human1.66081523
61IKZF1_21737484_ChIP-ChIP_HCT116_Human1.65177362
62SMARCA4_20176728_ChIP-ChIP_TSCs_Mouse1.62241563
63NELFA_20434984_ChIP-Seq_ESCs_Mouse1.61754336
64ZFP281_18757296_ChIP-ChIP_E14_Mouse1.61232676
65TP53_22127205_ChIP-Seq_IMR90_Human1.60537617
66KDM5A_27292631_Chip-Seq_BREAST_Human1.60450788
67NR0B1_18358816_ChIP-ChIP_MESCs_Mouse1.58577916
68AR_21909140_ChIP-Seq_LNCAP_Human1.58242619
69POU5F1_18555785_ChIP-Seq_MESCs_Mouse1.57354260
70ZFX_18555785_ChIP-Seq_MESCs_Mouse1.56171186
71ATF3_27146783_Chip-Seq_COLON_Human1.54770635
72* JARID2_20075857_ChIP-Seq_MESCs_Mouse1.53674006
73VDR_23849224_ChIP-Seq_CD4+_Human1.46536415
74* HSF1_23293686_ChIP-Seq_STHDH_STRIATAL_Mouse1.46519015
75TBX5_21415370_ChIP-Seq_HL-1_Mouse1.45370161
76MYCN_18555785_ChIP-Seq_MESCs_Mouse1.44642360
77MYC_18555785_ChIP-Seq_MESCs_Mouse1.43608007
78* TET1_21451524_ChIP-Seq_MESCs_Mouse1.43305209
79TBP_23326641_ChIP-Seq_C3H10T1-2_Mouse1.42472287
80TP53_20018659_ChIP-ChIP_R1E_Mouse1.41287570
81EKLF_21900194_ChIP-Seq_ERYTHROCYTE_Mouse1.40179014
82ELK1_22589737_ChIP-Seq_MCF10A_Human1.38621279
83SOX2_20726797_ChIP-Seq_SW620_Human1.38033551
84TCF21_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human1.37503830
85E2F1_21310950_ChIP-Seq_MCF-7_Human1.36983242
86FOXO3_22982991_ChIP-Seq_MACROPHAGES_Mouse1.35580106
87ELF1_17652178_ChIP-ChIP_JURKAT_Human1.34417730
88UBF1/2_26484160_Chip-Seq_HMEC-DERIVED_Human1.33441959
89CEBPB_24764292_ChIP-Seq_MC3T3_Mouse1.32889435
90LXR_22292898_ChIP-Seq_THP-1_Human1.30458100
91TAF7L_23326641_ChIP-Seq_C3H10T1-2_Mouse1.30316331
92FOXP3_21729870_ChIP-Seq_TREG_Human1.30222652
93SMC1_22415368_ChIP-Seq_MEFs_Mouse1.30071405
94* PHC1_16625203_ChIP-ChIP_MESCs_Mouse1.28737305
95ESR1_20079471_ChIP-ChIP_T-47D_Human1.27768971
96MYBL2_22936984_ChIP-ChIP_MESCs_Mouse1.26535492
97P63_26484246_Chip-Seq_KERATINOCYTES_Human1.25682747
98CNOT3_19339689_ChIP-ChIP_MESCs_Mouse1.22734846
99* SUZ12_18692474_ChIP-Seq_MEFs_Mouse1.21157934
100ZFP42_18358816_ChIP-ChIP_MESCs_Mouse1.20722326
101ZIC3_20872845_ChIP-ChIP_MESCs_Mouse1.20525461
102SMAD2_18955504_ChIP-ChIP_HaCaT_Human1.19904161
103SMAD3_18955504_ChIP-ChIP_HaCaT_Human1.19904161
104CREB1_26743006_Chip-Seq_LNCaP-abl_Human1.19157378
105GATA6_25053715_ChIP-Seq_YYC3_Human1.18982202
106* RNF2_18974828_ChIP-Seq_MESCs_Mouse1.18371254
107* EZH2_18974828_ChIP-Seq_MESCs_Mouse1.18371254
108STAT3_1855785_ChIP-Seq_MESCs_Mouse1.18311699
109CTCF_18555785_ChIP-Seq_MESCs_Mouse1.18092596
110GATA4_25053715_ChIP-Seq_YYC3_Human1.17367428
111* EED_16625203_ChIP-ChIP_MESCs_Mouse1.16933690
112ERG_21242973_ChIP-ChIP_JURKAT_Human1.16887953
113E2F4_21247883_ChIP-Seq_LYMPHOBLASTOID_Human1.16329286
114EP300_20729851_ChIP-Seq_FORBRAIN_MIDBRAIN_LIMB_HEART_Mouse1.16224890
115POU5F1_18358816_ChIP-ChIP_MESCs_Mouse1.14602389
116SOX2_27498859_Chip-Seq_STOMACH_Mouse1.13849243
117VDR_22108803_ChIP-Seq_LS180_Human1.13448953
118ESR1_15608294_ChIP-ChIP_MCF-7_Human1.11496163
119HNF4A_19761587_ChIP-ChIP_CACO-2_Human1.11445483
120MEF2A_21415370_ChIP-Seq_HL-1_Mouse1.10425553
121KLF4_18555785_ChIP-Seq_MESCs_Mouse1.10218876
122* TCF3_18692474_ChIP-Seq_MEFs_Mouse1.10160415
123MYC_18940864_ChIP-ChIP_HL60_Human1.08220876
124* ZFP281_27345836_Chip-Seq_ESCs_Mouse1.08163431
125ATF3_23680149_ChIP-Seq_GBM1-GSC_Human1.07115749
126* RING1B_27294783_Chip-Seq_NPCs_Mouse1.06841356
127HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse1.06540752
128CEBPB_21427703_ChIP-Seq_3T3-L1_Mouse1.04958714
129KLF4_19030024_ChIP-ChIP_MESCs_Mouse1.04577794
130P300_27058665_Chip-Seq_ZR-75-30cells_Human1.04445261
131GATA3_20176728_ChIP-ChIP_TSCs_Mouse1.03659711
132PPARD_23176727_ChIP-Seq_KERATINOCYTES_Mouse1.03541189
133* BMI1_23680149_ChIP-Seq_NPCS_Mouse1.03284967
134* EZH2_27304074_Chip-Seq_ESCs_Mouse1.02871912
135TRIM28_19339689_ChIP-ChIP_MESCs_Mouse1.02847364
136PPARD_23208498_ChIP-Seq_MDA-MB-231_Human1.02017000
137YY1_21170310_ChIP-Seq_MESCs_Mouse1.01573143
138* NANOG_18692474_ChIP-Seq_MEFs_Mouse1.00850293
139POU5F1_16153702_ChIP-ChIP_HESCs_Human1.00674076
140TFAP2C_20629094_ChIP-Seq_MCF-7_Human1.00376328
141WT1_19549856_ChIP-ChIP_CCG9911_Human1.00145667
142* CDX2_19796622_ChIP-Seq_MESCs_Mouse1.00095355
143SA1_27219007_Chip-Seq_ERYTHROID_Human0.99665882
144ZNF652_21678463_ChIP-ChIP_ZR75-1_Human0.99231048
145* KDM2B_26808549_Chip-Seq_SUP-B15_Human0.98864166
146ELF3_26769127_Chip-Seq_PDAC-Cell_line_Human0.98373455
147BMI1_19503595_ChIP-Seq_MEFsC_Mouse0.97790932
148SREBP2_21459322_ChIP-Seq_LIVER_Mouse0.97565423
149FOXM1_23109430_ChIP-Seq_U2OS_Human0.96950247
150SIN3A_21632747_ChIP-Seq_MESCs_Mouse0.96609088
151SOX2_18692474_ChIP-Seq_MEFs_Mouse0.95219078
152FOXP1_21924763_ChIP-Seq_HESCs_Human0.94645629
153* OCT4_18692474_ChIP-Seq_MEFs_Mouse0.94326237
154* RING1B_27294783_Chip-Seq_ESCs_Mouse0.93123333
155UBF1/2_26484160_Chip-Seq_HMECs_Human0.92898500
156ESRRB_18555785_ChIP-Seq_MESCs_Mouse0.92657163
157CTCF_21964334_ChIP-Seq_BJAB-B_Human0.92491424
158P68_20966046_ChIP-Seq_HELA_Human0.91732757
159FOXO3_23340844_ChIP-Seq_DLD1_Human0.91458729
160NANOG_16153702_ChIP-ChIP_HESCs_Human0.91290644
161ELF1_20517297_ChIP-Seq_JURKAT_Human0.90788111
162* CTCF_27219007_Chip-Seq_ERYTHROID_Human0.90599279
163CCND1_20090754_ChIP-ChIP_RETINA_Mouse0.90159782
164ELF5_23300383_ChIP-Seq_T47D_Human0.90046997
165BCL3_23251550_ChIP-Seq_MUSCLE_Mouse0.89338039
166PAX6_23342162_ChIP-ChIP_BETA-FORBRAIN-LENS_Mouse0.89320397
167SREBP1_19666523_ChIP-Seq_LIVER_Mouse0.87387683
168RUNX1_26923725_Chip-Seq_MACROPHAGESS_Mouse0.84801228
169PADI4_21655091_ChIP-ChIP_MCF-7_Human0.84550089
170ASH2L_23239880_ChIP-Seq_MESCs_Mouse0.84179312
171ERG_20887958_ChIP-Seq_HPC-7_Mouse0.83157926
172CREM_20920259_ChIP-Seq_GC1-SPG_Mouse0.82225319
173SOX17_20123909_ChIP-Seq_XEN_Mouse0.82110733

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0010030_abnormal_orbit_morphology4.58808573
2MP0005360_urolithiasis4.12875433
3MP0003950_abnormal_plasma_membrane3.82065247
4MP0003705_abnormal_hypodermis_morpholog3.71952934
5MP0002877_abnormal_melanocyte_morpholog3.10367359
6MP0000013_abnormal_adipose_tissue3.06427457
7MP0009697_abnormal_copulation2.99418140
8MP0003693_abnormal_embryo_hatching2.97219359
9MP0001879_abnormal_lymphatic_vessel2.62987386
10MP0008438_abnormal_cutaneous_collagen2.61852752
11MP0004272_abnormal_basement_membrane2.60898195
12MP0000372_irregular_coat_pigmentation2.60054244
13MP0000534_abnormal_ureter_morphology2.54239034
14MP0005623_abnormal_meninges_morphology2.39366034
15MP0003283_abnormal_digestive_organ2.35858539
16MP0000537_abnormal_urethra_morphology2.23218073
17MP0003136_yellow_coat_color2.22656781
18MP0001849_ear_inflammation2.20457327
19MP0010368_abnormal_lymphatic_system2.05343351
20MP0003315_abnormal_perineum_morphology2.01304225
21MP0002160_abnormal_reproductive_system2.00639099
22MP0005275_abnormal_skin_tensile1.98441973
23MP0005171_absent_coat_pigmentation1.96179191
24MP0009053_abnormal_anal_canal1.91847904
25MP0004043_abnormal_pH_regulation1.91811447
26MP0003942_abnormal_urinary_system1.90107215
27MP0010352_gastrointestinal_tract_polyps1.89994372
28MP0004264_abnormal_extraembryonic_tissu1.88429522
29MP0005408_hypopigmentation1.86434643
30MP0004858_abnormal_nervous_system1.80566105
31MP0003385_abnormal_body_wall1.76500707
32MP0005167_abnormal_blood-brain_barrier1.75708025
33MP0001756_abnormal_urination1.73427369
34MP0001661_extended_life_span1.73125436
35MP0003122_maternal_imprinting1.71052971
36MP0009250_abnormal_appendicular_skeleto1.70317016
37MP0003566_abnormal_cell_adhesion1.70048631
38MP0005503_abnormal_tendon_morphology1.66974655
39MP0000015_abnormal_ear_pigmentation1.66860377
40MP0001765_abnormal_ion_homeostasis1.65778347
41MP0005670_abnormal_white_adipose1.65388544
42MP0001958_emphysema1.62889790
43MP0004019_abnormal_vitamin_homeostasis1.61744556
44MP0009379_abnormal_foot_pigmentation1.61711646
45MP0005187_abnormal_penis_morphology1.57965071
46MP0005451_abnormal_body_composition1.57293981
47MP0009643_abnormal_urine_homeostasis1.55655954
48MP0000749_muscle_degeneration1.54696450
49MP0002932_abnormal_joint_morphology1.54167883
50MP0000003_abnormal_adipose_tissue1.48581036
51MP0008932_abnormal_embryonic_tissue1.43637528
52MP0001188_hyperpigmentation1.43407532
53MP0003123_paternal_imprinting1.42296276
54MP0002163_abnormal_gland_morphology1.42050129
55MP0005332_abnormal_amino_acid1.40877479
56MP0003806_abnormal_nucleotide_metabolis1.40529034
57MP0003718_maternal_effect1.36483903
58MP0003077_abnormal_cell_cycle1.36455479
59MP0003279_aneurysm1.36259890
60MP0001348_abnormal_lacrimal_gland1.35349841
61MP0002796_impaired_skin_barrier1.35287001
62MP0003786_premature_aging1.34806522
63MP0008058_abnormal_DNA_repair1.32679268
64MP0003111_abnormal_nucleus_morphology1.30147684
65MP0002938_white_spotting1.28701870
66MP0004957_abnormal_blastocyst_morpholog1.27550434
67MP0003186_abnormal_redox_activity1.25169002
68MP0005174_abnormal_tail_pigmentation1.23402825
69MP0000678_abnormal_parathyroid_gland1.21774111
70MP0005636_abnormal_mineral_homeostasis1.21724442
71MP0004782_abnormal_surfactant_physiolog1.21470706
72MP0000762_abnormal_tongue_morphology1.20222183
73MP0010094_abnormal_chromosome_stability1.19708752
74MP0000538_abnormal_urinary_bladder1.19198773
75MP0006036_abnormal_mitochondrial_physio1.18212213
76MP0002282_abnormal_trachea_morphology1.17905279
77MP0002060_abnormal_skin_morphology1.17348666
78MP0002095_abnormal_skin_pigmentation1.15459646
79MP0002136_abnormal_kidney_physiology1.15425994
80MP0008007_abnormal_cellular_replicative1.15395127
81MP0001664_abnormal_digestion1.14956255
82MP0003941_abnormal_skin_development1.14592702
83MP0009384_cardiac_valve_regurgitation1.14487090
84MP0001881_abnormal_mammary_gland1.12341044
85MP0003300_gastrointestinal_ulcer1.10415518
86MP0005023_abnormal_wound_healing1.09750576
87MP0005508_abnormal_skeleton_morphology1.05287312
88MP0005501_abnormal_skin_physiology1.04368038
89MP0006054_spinal_hemorrhage1.03474439
90MP0002249_abnormal_larynx_morphology1.02674968
91MP0005257_abnormal_intraocular_pressure1.02657481
92MP0000477_abnormal_intestine_morphology1.01778253
93MP0001873_stomach_inflammation1.01398419
94MP0002234_abnormal_pharynx_morphology1.01092510
95MP0003115_abnormal_respiratory_system1.00572993
96MP0000733_abnormal_muscle_development1.00200751
97MP0002896_abnormal_bone_mineralization0.99883078
98MP0005076_abnormal_cell_differentiation0.99529877
99MP0010234_abnormal_vibrissa_follicle0.99470425
100MP0005666_abnormal_adipose_tissue0.99415220
101MP0000163_abnormal_cartilage_morphology0.99308321
102MP0004185_abnormal_adipocyte_glucose0.99297379
103MP0000681_abnormal_thyroid_gland0.99232638
104* MP0002114_abnormal_axial_skeleton0.99018214
105MP0005389_reproductive_system_phenotype0.98955273
106MP0002102_abnormal_ear_morphology0.98264323
107MP0003937_abnormal_limbs/digits/tail_de0.95913936
108MP0000358_abnormal_cell_content/0.95548055
109MP0005083_abnormal_biliary_tract0.95218165
110MP0002139_abnormal_hepatobiliary_system0.92257489
111MP0000462_abnormal_digestive_system0.91087499
112MP0002177_abnormal_outer_ear0.91042400
113MP0002115_abnormal_skeleton_extremities0.89942251
114MP0003755_abnormal_palate_morphology0.89445305
115MP0004233_abnormal_muscle_weight0.89247618
116MP0008775_abnormal_heart_ventricle0.88893281
117MP0000647_abnormal_sebaceous_gland0.88814350
118MP0000049_abnormal_middle_ear0.87258183
119MP0002210_abnormal_sex_determination0.86186636
120MP0005084_abnormal_gallbladder_morpholo0.85832407
121MP0005375_adipose_tissue_phenotype0.85476449
122MP0003936_abnormal_reproductive_system0.84396687
123MP0004883_abnormal_blood_vessel0.83919269
124MP0001324_abnormal_eye_pigmentation0.83066174
125MP0002295_abnormal_pulmonary_circulatio0.82939181
126MP0002113_abnormal_skeleton_development0.81081424
127MP0002135_abnormal_kidney_morphology0.80993469
128MP0000490_abnormal_crypts_of0.80452930
129MP0002111_abnormal_tail_morphology0.78438412
130MP0003453_abnormal_keratinocyte_physiol0.78019786
131MP0000627_abnormal_mammary_gland0.77013657
132MP0003724_increased_susceptibility_to0.75802124
133MP0005085_abnormal_gallbladder_physiolo0.75701322
134MP0000230_abnormal_systemic_arterial0.74800776
135MP0002108_abnormal_muscle_morphology0.74151610
136MP0005409_darkened_coat_color0.73899215
137MP0003878_abnormal_ear_physiology0.73675709
138MP0005377_hearing/vestibular/ear_phenot0.73675709
139MP0000427_abnormal_hair_cycle0.73625765
140MP0000516_abnormal_urinary_system0.72744262
141MP0005367_renal/urinary_system_phenotyp0.72744262
142MP0001270_distended_abdomen0.72505186
143MP0000767_abnormal_smooth_muscle0.72371360
144MP0001614_abnormal_blood_vessel0.71237926
145MP0000566_synostosis0.71221329
146MP0002098_abnormal_vibrissa_morphology0.71106725
147MP0002233_abnormal_nose_morphology0.70571795
148MP0002109_abnormal_limb_morphology0.70403307
149MP0004084_abnormal_cardiac_muscle0.69874219
150MP0000428_abnormal_craniofacial_morphol0.69636474
151MP0000432_abnormal_head_morphology0.68906576
152MP0003091_abnormal_cell_migration0.68825304
153MP0005330_cardiomyopathy0.68027341
154MP0002925_abnormal_cardiovascular_devel0.67835708
155MP0002085_abnormal_embryonic_tissue0.66676048
156MP0000350_abnormal_cell_proliferation0.65540602
157MP0010678_abnormal_skin_adnexa0.65154264
158MP0001697_abnormal_embryo_size0.63287822
159MP0002084_abnormal_developmental_patter0.62185987

Predicted human phenotypes

RankGene SetZ-score
1Metabolic alkalosis (HP:0200114)5.81257841
2Hyperactive renin-angiotensin system (HP:0000841)5.22414560
3Thin bony cortex (HP:0002753)3.95568857
4Delayed epiphyseal ossification (HP:0002663)3.79421401
5Abnormality of chloride homeostasis (HP:0011422)3.78703449
6Polygenic inheritance (HP:0010982)3.74448046
7Aortic aneurysm (HP:0004942)3.69151926
8Abnormality of the musculature of the hand (HP:0001421)3.62887847
9Unilateral renal agenesis (HP:0000122)3.52782131
10Protrusio acetabuli (HP:0003179)3.52125611
11Hyperaldosteronism (HP:0000859)3.48083350
12Asymmetry of the thorax (HP:0001555)3.47701260
13Abnormality of renin-angiotensin system (HP:0000847)3.45373172
14Increased purine levels (HP:0004368)3.42394645
15Hyperuricemia (HP:0002149)3.42394645
16Abnormality of the fetal cardiovascular system (HP:0010948)3.34710579
17Abnormal umbilical cord blood vessels (HP:0011403)3.34710579
18Single umbilical artery (HP:0001195)3.34710579
19Aplasia/Hypoplasia of the fovea (HP:0008060)3.27822587
20Hypoplasia of the fovea (HP:0007750)3.27822587
21Decreased activity of mitochondrial respiratory chain (HP:0008972)3.26441678
22Abnormal activity of mitochondrial respiratory chain (HP:0011922)3.26441678
23Increased circulating renin level (HP:0000848)3.18764319
24Fibular aplasia (HP:0002990)3.18266356
25Hypomagnesemia (HP:0002917)3.14419489
26Hypokalemic alkalosis (HP:0001949)3.10193328
27Reticulocytopenia (HP:0001896)2.98133029
28Gout (HP:0001997)2.89929291
29Abnormality of the umbilical cord (HP:0010881)2.89457720
30Alkalosis (HP:0001948)2.84450547
31Abnormality of magnesium homeostasis (HP:0004921)2.84383317
32Abnormal mitochondria in muscle tissue (HP:0008316)2.82882957
33Hepatoblastoma (HP:0002884)2.77594256
34Multifactorial inheritance (HP:0001426)2.75408297
35Acute necrotizing encephalopathy (HP:0006965)2.74635778
36Aplasia/Hypoplasia of the macula (HP:0008059)2.71498519
37Rhabdomyosarcoma (HP:0002859)2.69217553
38Abnormality of the proximal phalanges of the hand (HP:0009834)2.69200942
39Increased CSF lactate (HP:0002490)2.68463760
40Neonatal short-limb short stature (HP:0008921)2.64647379
41Fibular hypoplasia (HP:0003038)2.61580615
42Bifid uvula (HP:0000193)2.55120787
43Fragile skin (HP:0001030)2.54204306
44Proximal tubulopathy (HP:0000114)2.54094477
45Renal salt wasting (HP:0000127)2.53316372
46Aplasia/Hypoplasia affecting the retina (HP:0008061)2.53095167
47Hypokalemia (HP:0002900)2.51226935
48Horseshoe kidney (HP:0000085)2.50218465
49Acute encephalopathy (HP:0006846)2.49661634
50Abnormality of the fovea (HP:0000493)2.49015035
51Short humerus (HP:0005792)2.44565947
52Lipid accumulation in hepatocytes (HP:0006561)2.44214206
53Soft skin (HP:0000977)2.42957807
54Shawl scrotum (HP:0000049)2.42435253
55Abnormality of purine metabolism (HP:0004352)2.42414184
56Patchy hypopigmentation of hair (HP:0011365)2.42090662
57Aplasia/Hypoplasia of the sacrum (HP:0008517)2.40966375
58Type II lissencephaly (HP:0007260)2.39489087
59Abnormality of the distal phalanx of the thumb (HP:0009617)2.37309325
60Adrenal hypoplasia (HP:0000835)2.37074876
61Aplasia/hypoplasia of the humerus (HP:0006507)2.36926763
62Premature rupture of membranes (HP:0001788)2.36332684
63Ulnar bowing (HP:0003031)2.35463133
64Abnormality of glutamine family amino acid metabolism (HP:0010902)2.34953950
65Mitochondrial inheritance (HP:0001427)2.34604348
66Abnormalities of placenta or umbilical cord (HP:0001194)2.32565765
67Increased hepatocellular lipid droplets (HP:0006565)2.31214536
68Aortic dissection (HP:0002647)2.30575196
69White forelock (HP:0002211)2.28882149
70Long nose (HP:0003189)2.28305883
71Concave nail (HP:0001598)2.26699249
72Tetany (HP:0001281)2.25766951
73Cerebral edema (HP:0002181)2.24954095
74Broad distal phalanx of finger (HP:0009836)2.20421496
75Ileus (HP:0002595)2.17798180
76Macrocytic anemia (HP:0001972)2.17008506
77Flat capital femoral epiphysis (HP:0003370)2.15657711
78Cutaneous melanoma (HP:0012056)2.15469138
79Hepatic necrosis (HP:0002605)2.14853481
80Vascular tortuosity (HP:0004948)2.14700005
81Aplasia/Hypoplasia of the fibula (HP:0006492)2.12977322
82Progressive macrocephaly (HP:0004481)2.10770820
83Lymphangioma (HP:0100764)2.09725575
84Abnormality of carpal bone ossification (HP:0006257)2.09524823
85Microretrognathia (HP:0000308)2.08845178
86Hepatocellular necrosis (HP:0001404)2.08500513
87Oligomenorrhea (HP:0000876)2.07152699
88Focal segmental glomerulosclerosis (HP:0000097)2.06297017
89Increased serum lactate (HP:0002151)2.06281584
90Abnormality of the distal phalanges of the toes (HP:0010182)2.05186493
91Anal stenosis (HP:0002025)2.04620243
92Absent thumb (HP:0009777)2.04245956
93Neoplasm of striated muscle (HP:0009728)2.02695346
94Reduced subcutaneous adipose tissue (HP:0003758)2.02478430
95Abnormal ossification of hand bones (HP:0005921)2.02403207
96Polyuria (HP:0000103)2.02071951
97Glomerulosclerosis (HP:0000096)2.01638876
98Glycosuria (HP:0003076)2.01635091
99Abnormality of urine glucose concentration (HP:0011016)2.01635091
100Right ventricular cardiomyopathy (HP:0011663)2.00241651
101Lactic acidosis (HP:0003128)1.98477574
102Renal Fanconi syndrome (HP:0001994)1.97942741
103Pallor (HP:0000980)1.97452190
104Patent foramen ovale (HP:0001655)1.96780680
105Hypoalphalipoproteinemia (HP:0003233)1.96736616
106Potter facies (HP:0002009)1.94723372
107Facial shape deformation (HP:0011334)1.94723372
108Rough bone trabeculation (HP:0100670)1.94482081
109Opisthotonus (HP:0002179)1.93496157
110Abnormal urine output (HP:0012590)1.93400310
111Abnormality of the calcaneus (HP:0008364)1.92693819
112Achilles tendon contracture (HP:0001771)1.92266785
113Increased muscle lipid content (HP:0009058)1.91699962
114Wide anterior fontanel (HP:0000260)1.91329252
115Abnormality of glycolysis (HP:0004366)1.91225188
116Hypoplasia of the uterus (HP:0000013)1.91134182
117Bicornuate uterus (HP:0000813)1.91019311
118Retinal dysplasia (HP:0007973)1.90706788
119Nonimmune hydrops fetalis (HP:0001790)1.89590554
120Annular pancreas (HP:0001734)1.89499563
121Type I transferrin isoform profile (HP:0003642)1.88290103
122Increased intramyocellular lipid droplets (HP:0012240)1.87736410
123Abnormal isoelectric focusing of serum transferrin (HP:0003160)1.87410432
124Abnormal protein N-linked glycosylation (HP:0012347)1.87410432
125Abnormal protein glycosylation (HP:0012346)1.87410432
126Abnormal glycosylation (HP:0012345)1.87410432
127Adrenal overactivity (HP:0002717)1.86042387
128Shallow orbits (HP:0000586)1.85236759
129Follicular hyperkeratosis (HP:0007502)1.84770079
130Abnormality of renal excretion (HP:0011036)1.84355772
131Redundant skin (HP:0001582)1.84126749
132Abnormality of placental membranes (HP:0011409)1.83932501
133Amniotic constriction ring (HP:0009775)1.83932501
134Biconcave vertebral bodies (HP:0004586)1.82971274
135Esophageal neoplasm (HP:0100751)1.82934334
136Neoplasm of head and neck (HP:0012288)1.82934334
137Carpal bone hypoplasia (HP:0001498)1.82599907
138Renal duplication (HP:0000075)1.82022622
139Congenital sensorineural hearing impairment (HP:0008527)1.80063418
140Vertebral arch anomaly (HP:0008438)1.79915671
141Sparse eyelashes (HP:0000653)1.79159766
142Trismus (HP:0000211)1.78388866
143Elbow flexion contracture (HP:0002987)1.78355150
144Turricephaly (HP:0000262)1.77840052
145Hypokinesia (HP:0002375)1.76579971
146Abnormal number of erythroid precursors (HP:0012131)1.73868101
147Squamous cell carcinoma (HP:0002860)1.73818350
148Respiratory failure (HP:0002878)1.73787501
149Hypoplasia of the pons (HP:0012110)1.72846208
150Abnormality of sodium homeostasis (HP:0010931)1.72803811
151Hyperthyroidism (HP:0000836)1.72025083
152Muscle stiffness (HP:0003552)1.71395975
153Aplasia/Hypoplasia involving the carpal bones (HP:0006502)1.70534831
154Spinal rigidity (HP:0003306)1.70178000
155Abnormality of cells of the erythroid lineage (HP:0012130)1.69969761
156Increased serum pyruvate (HP:0003542)1.69895903
157Metaphyseal cupping (HP:0003021)1.69785110
158Nasal speech (HP:0001611)1.69607447
159Mesangial abnormality (HP:0001966)1.69338550
160Aplasia/Hypoplasia of the uvula (HP:0010293)1.69193419
161Elevated circulating parathyroid hormone (PTH) level (HP:0003165)1.69040444
162Ankyloglossia (HP:0010296)1.68742174
163Abnormality of the anterior horn cell (HP:0006802)1.68663151
164Degeneration of anterior horn cells (HP:0002398)1.68663151
165Partial agenesis of the corpus callosum (HP:0001338)1.68615574
166Abnormality of proline metabolism (HP:0010907)1.68455673
167Hydroxyprolinuria (HP:0003080)1.68455673
168Entropion (HP:0000621)1.67877302
169Hypercalciuria (HP:0002150)1.67857026
170Short middle phalanx of the 5th finger (HP:0004220)1.67462425
171Increased connective tissue (HP:0009025)1.66150000
17211 pairs of ribs (HP:0000878)1.65954669
173Decreased circulating renin level (HP:0003351)1.65649930
174Hyponatremia (HP:0002902)1.65623521
175Abnormality of potassium homeostasis (HP:0011042)1.65456091
176Peritonitis (HP:0002586)1.65187377
177Renal cortical cysts (HP:0000803)1.64689769
178Coronal craniosynostosis (HP:0004440)1.64443730
179Cervical subluxation (HP:0003308)1.64297738
180Flared iliac wings (HP:0002869)1.64273616
181Confusion (HP:0001289)1.64109990
182Global brain atrophy (HP:0002283)1.61375670
183Hyperphosphaturia (HP:0003109)1.60869795
184Abnormal hemoglobin (HP:0011902)1.60808505
185Arterial tortuosity (HP:0005116)1.60802696
186Tibial bowing (HP:0002982)1.60552379
187Abnormality of nucleobase metabolism (HP:0010932)1.59813374
188Abnormal pancreas size (HP:0012094)1.59686965

Predicted kinase interactions (KEA)

RankGene SetZ-score
1TESK25.86700713
2MST1R4.28980874
3TESK13.70860572
4AKT33.02779495
5EPHA22.90956551
6PRKD32.75917000
7WNK42.74906450
8TRIB32.74884244
9ARAF2.72210989
10MAP3K122.71104253
11LIMK12.65629229
12ERN12.65045597
13PKN22.57237877
14EPHB22.33080102
15MST42.25693516
16LATS22.14739024
17EIF2AK12.08549360
18WEE12.08453588
19WNK32.07098338
20ACVR1B1.96871222
21OXSR11.93530385
22ERBB41.92664871
23STK38L1.92329311
24TRIM281.80036823
25DDR21.71159729
26CDK121.69293637
27TTN1.64894217
28KDR1.64205822
29BRAF1.62817918
30ERBB31.59750180
31PAK41.56883661
32STK161.55962925
33MAP3K91.52097384
34NME21.50923718
35EIF2AK31.50635237
36NEK21.48082187
37NEK11.47706658
38MYLK1.43455246
39LRRK21.42470428
40STK101.38689687
41LMTK21.34015630
42PTK61.33673501
43BUB11.29193904
44MUSK1.29186553
45DMPK1.25260544
46PDGFRA1.23819440
47NTRK11.23106363
48WNK11.23060571
49DAPK31.22974907
50VRK21.22708549
51FER1.22237739
52PINK11.22168422
53TGFBR21.19069468
54BMPR1B1.18906335
55STK391.18076500
56PLK41.14806509
57NME11.13433675
58IRAK31.13135349
59CDK91.12551529
60TIE11.11110355
61MATK1.08701507
62MAP2K11.06986153
63CDK81.00941822
64PRKCI0.99456038
65MAPKAPK50.99125181
66PTK20.98499290
67PBK0.98180295
68CCNB10.97353638
69PNCK0.93919459
70MELK0.93118066
71GRK60.92163775
72PTK2B0.90019754
73SIK30.89787054
74FRK0.88255697
75PAK20.87379695
76RPS6KB20.87207326
77BRSK10.86643749
78CHEK20.84459724
79ERBB20.82967829
80PAK10.81780651
81TLK10.79647535
82MOS0.75867956
83CDC70.75686777
84BMX0.73673480
85PRKG20.72953607
86PLK20.72266109
87CDK70.71862653
88AURKA0.71537994
89STK30.68565780
90CLK10.67860121
91MARK30.67167069
92PLK30.66891644
93STK380.65395067
94EEF2K0.65306095
95GRK50.64746299
96TGFBR10.64239376
97LATS10.62633025
98ROCK10.59681108
99GRK10.59343801
100ZAK0.59179328
101MINK10.58965197
102PAK30.57479142
103CSNK1G10.57121572
104CSNK1G30.56527083
105CSNK1A1L0.53507399
106TYRO30.51767339
107ILK0.50191203
108SRC0.49235549
109BRSK20.48067151
110SRPK10.47910868
111BCKDK0.47744430
112ADRBK10.44824281
113* CSNK2A20.44390825
114EPHB10.43739841
115EPHA30.43132539
116MAP3K80.42531962
117AKT20.41731290
118RET0.41693417
119ROCK20.41167677
120CDK140.40906185
121CHEK10.40250982
122EIF2AK20.40238400
123PRKD10.39771766
124* CSNK2A10.38429680
125MET0.38016528
126PDK20.37740978
127MAP2K20.37587197
128RAF10.37521453
129PIK3CG0.37135093
130MAP3K100.36702387
131CDK150.35293505
132TAOK10.34014852
133AURKB0.33917465
134IGF1R0.33896759
135CDK180.33837000
136FGFR10.33657092
137PLK10.31158088
138RIPK10.30821354
139MTOR0.30690261
140BCR0.30479856
141SCYL20.26485229
142NEK90.24315677
143PIM20.24226196
144CDC42BPA0.24004162
145ABL20.23569535
146CDK11A0.23556503
147MAPK80.23522213
148MAPK110.23510349
149ICK0.23315188
150TTK0.23142041

Predicted pathways (KEGG)

RankGene SetZ-score
1Cyanoamino acid metabolism_Homo sapiens_hsa004606.37923566
2Proteasome_Homo sapiens_hsa030503.55020802
3Synthesis and degradation of ketone bodies_Homo sapiens_hsa000723.15015256
4Ascorbate and aldarate metabolism_Homo sapiens_hsa000532.88577341
5Sulfur metabolism_Homo sapiens_hsa009202.65719050
6Taurine and hypotaurine metabolism_Homo sapiens_hsa004302.63210053
7Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001302.56309317
8Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030082.54369813
9Glutathione metabolism_Homo sapiens_hsa004802.43061438
10DNA replication_Homo sapiens_hsa030302.40616814
11Chemical carcinogenesis_Homo sapiens_hsa052042.24376862
12Pentose and glucuronate interconversions_Homo sapiens_hsa000402.13910816
13Oxidative phosphorylation_Homo sapiens_hsa001902.13897287
14Pyrimidine metabolism_Homo sapiens_hsa002402.12303241
15Butanoate metabolism_Homo sapiens_hsa006502.04315441
16Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa009702.00573916
17Valine, leucine and isoleucine degradation_Homo sapiens_hsa002801.97533175
18Mineral absorption_Homo sapiens_hsa049781.94303445
19Parkinsons disease_Homo sapiens_hsa050121.94079363
20Ribosome_Homo sapiens_hsa030101.94057095
21Protein export_Homo sapiens_hsa030601.93599478
22Homologous recombination_Homo sapiens_hsa034401.88819064
23Mismatch repair_Homo sapiens_hsa034301.87450700
24Pentose phosphate pathway_Homo sapiens_hsa000301.78823813
25Thyroid cancer_Homo sapiens_hsa052161.77856228
26Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009801.77308060
272-Oxocarboxylic acid metabolism_Homo sapiens_hsa012101.72249614
28Folate biosynthesis_Homo sapiens_hsa007901.64751747
29Citrate cycle (TCA cycle)_Homo sapiens_hsa000201.64197511
30RNA polymerase_Homo sapiens_hsa030201.57110872
31Fatty acid degradation_Homo sapiens_hsa000711.56500354
32Carbon metabolism_Homo sapiens_hsa012001.54409713
33Nucleotide excision repair_Homo sapiens_hsa034201.52965012
34Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008601.50166307
35Drug metabolism - cytochrome P450_Homo sapiens_hsa009821.49181416
36Alzheimers disease_Homo sapiens_hsa050101.48149396
37Tight junction_Homo sapiens_hsa045301.46690630
38Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006301.46244558
39Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049321.45557485
40RNA transport_Homo sapiens_hsa030131.43762009
41Pyruvate metabolism_Homo sapiens_hsa006201.41047954
42Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049641.39675222
43Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa049611.37308761
44Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006011.36934881
45One carbon pool by folate_Homo sapiens_hsa006701.35396996
46Bile secretion_Homo sapiens_hsa049761.32479098
47Terpenoid backbone biosynthesis_Homo sapiens_hsa009001.30447222
48Cysteine and methionine metabolism_Homo sapiens_hsa002701.25105591
49N-Glycan biosynthesis_Homo sapiens_hsa005101.22929108
50Base excision repair_Homo sapiens_hsa034101.20715880
51Fructose and mannose metabolism_Homo sapiens_hsa000511.20083244
52Protein digestion and absorption_Homo sapiens_hsa049741.19515277
53Glycolysis / Gluconeogenesis_Homo sapiens_hsa000101.19243782
54Selenocompound metabolism_Homo sapiens_hsa004501.19153849
55Protein processing in endoplasmic reticulum_Homo sapiens_hsa041411.17931445
56Fanconi anemia pathway_Homo sapiens_hsa034601.17636882
57Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006031.17599079
58Basal transcription factors_Homo sapiens_hsa030221.15169691
59Tryptophan metabolism_Homo sapiens_hsa003801.14658555
60Huntingtons disease_Homo sapiens_hsa050161.11538342
61Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa005201.09399550
62PPAR signaling pathway_Homo sapiens_hsa033201.07152444
63Purine metabolism_Homo sapiens_hsa002301.05587824
64Sulfur relay system_Homo sapiens_hsa041221.03551949
65Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010401.03014212
66Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005121.02919990
67Cardiac muscle contraction_Homo sapiens_hsa042600.99437539
68Cell cycle_Homo sapiens_hsa041100.98774562
69Hippo signaling pathway_Homo sapiens_hsa043900.96500647
70Steroid hormone biosynthesis_Homo sapiens_hsa001400.95422044
71ECM-receptor interaction_Homo sapiens_hsa045120.88860967
72Arachidonic acid metabolism_Homo sapiens_hsa005900.88420032
73Fatty acid metabolism_Homo sapiens_hsa012120.88210013
74Focal adhesion_Homo sapiens_hsa045100.87775017
75RNA degradation_Homo sapiens_hsa030180.86984717
76Propanoate metabolism_Homo sapiens_hsa006400.86192590
77Spliceosome_Homo sapiens_hsa030400.85569388
78Glycosaminoglycan degradation_Homo sapiens_hsa005310.83202904
79Biosynthesis of amino acids_Homo sapiens_hsa012300.81726311
80Thyroid hormone synthesis_Homo sapiens_hsa049180.81056476
81Leukocyte transendothelial migration_Homo sapiens_hsa046700.80344651
82TGF-beta signaling pathway_Homo sapiens_hsa043500.79939760
83Galactose metabolism_Homo sapiens_hsa000520.79072657
84Peroxisome_Homo sapiens_hsa041460.77346905
85p53 signaling pathway_Homo sapiens_hsa041150.76290087
86Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005630.75255280
87Bladder cancer_Homo sapiens_hsa052190.73770492
88Vitamin B6 metabolism_Homo sapiens_hsa007500.73366223
89Starch and sucrose metabolism_Homo sapiens_hsa005000.72752349
90Tyrosine metabolism_Homo sapiens_hsa003500.72009235
91Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa005340.71198580
92Arginine biosynthesis_Homo sapiens_hsa002200.69597451
93Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005330.67917648
94Renin-angiotensin system_Homo sapiens_hsa046140.67341300
95Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006040.67174789
96alpha-Linolenic acid metabolism_Homo sapiens_hsa005920.66337606
97Nitrogen metabolism_Homo sapiens_hsa009100.66089643
98Hedgehog signaling pathway_Homo sapiens_hsa043400.65506482
99Caffeine metabolism_Homo sapiens_hsa002320.65334747
100Sphingolipid metabolism_Homo sapiens_hsa006000.65245733
101Basal cell carcinoma_Homo sapiens_hsa052170.61743067
102Proteoglycans in cancer_Homo sapiens_hsa052050.60831016
103Phenylalanine metabolism_Homo sapiens_hsa003600.60160846
104Vasopressin-regulated water reabsorption_Homo sapiens_hsa049620.59378292
105Lysine degradation_Homo sapiens_hsa003100.58800365
106Ovarian steroidogenesis_Homo sapiens_hsa049130.57977633
107Drug metabolism - other enzymes_Homo sapiens_hsa009830.56397587
108Non-homologous end-joining_Homo sapiens_hsa034500.56001798
109Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004000.55396579
110Melanoma_Homo sapiens_hsa052180.54277469
111Retinol metabolism_Homo sapiens_hsa008300.54250101
112Vitamin digestion and absorption_Homo sapiens_hsa049770.51812694
113Adherens junction_Homo sapiens_hsa045200.51254607
114Axon guidance_Homo sapiens_hsa043600.50482497
115Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa049600.49810319
116AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa049330.47431210
117Rap1 signaling pathway_Homo sapiens_hsa040150.46390488
118Gastric acid secretion_Homo sapiens_hsa049710.46359482
119Oocyte meiosis_Homo sapiens_hsa041140.44245927
120Bacterial invasion of epithelial cells_Homo sapiens_hsa051000.44045611
121Vibrio cholerae infection_Homo sapiens_hsa051100.39994838
122Ubiquitin mediated proteolysis_Homo sapiens_hsa041200.39673985
123Gap junction_Homo sapiens_hsa045400.38610372
124Arrhythmogenic right ventricular cardiomyopathy (ARVC)_Homo sapiens_hsa054120.37427554
125SNARE interactions in vesicular transport_Homo sapiens_hsa041300.36967942
126Regulation of lipolysis in adipocytes_Homo sapiens_hsa049230.36109724
127Salivary secretion_Homo sapiens_hsa049700.35876548
128Fat digestion and absorption_Homo sapiens_hsa049750.35517339
129Cell adhesion molecules (CAMs)_Homo sapiens_hsa045140.34795125
130Glycerolipid metabolism_Homo sapiens_hsa005610.34380099
131Maturity onset diabetes of the young_Homo sapiens_hsa049500.33566578
132Vascular smooth muscle contraction_Homo sapiens_hsa042700.33004533
133Systemic lupus erythematosus_Homo sapiens_hsa053220.32703545
134Glycine, serine and threonine metabolism_Homo sapiens_hsa002600.32312901
135Linoleic acid metabolism_Homo sapiens_hsa005910.31828198
136Viral carcinogenesis_Homo sapiens_hsa052030.31224542
137Hepatitis C_Homo sapiens_hsa051600.30157194
138Pathogenic Escherichia coli infection_Homo sapiens_hsa051300.29617038
139Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa045500.29273825
140Regulation of actin cytoskeleton_Homo sapiens_hsa048100.26144434
141Dilated cardiomyopathy_Homo sapiens_hsa054140.25951130
142PI3K-Akt signaling pathway_Homo sapiens_hsa041510.24837642
143Pathways in cancer_Homo sapiens_hsa052000.23280134
144Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa051200.22935787
145Melanogenesis_Homo sapiens_hsa049160.22083991
146Metabolic pathways_Homo sapiens_hsa011000.19468264
147Fatty acid elongation_Homo sapiens_hsa000620.18691723
148Arginine and proline metabolism_Homo sapiens_hsa003300.17468310

Most similar genes based on co-expression Upload to Enrichr

Tissue Expression Export image »

Cell Line Expression Export image »