HOXB8

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: This gene is a member of the Antp homeobox family and encodes a nuclear protein with a homeobox DNA-binding domain. It is included in a cluster of homeobox B genes located on chromosome 17. The encoded protein functions as a sequence-specific transcription factor that is involved in development. Increased expression of this gene is associated with colorectal cancer. Mice that have had the murine ortholog of this gene knocked out exhibit an excessive pathologic grooming behavior. This behavior is similar to the behavior of humans suffering from the obsessive-compulsive spectrum disorder trichotillomania. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1glycine transport (GO:0015816)6.44015976
2thyroid gland development (GO:0030878)5.28369292
3L-amino acid import (GO:0043092)4.83481583
4sodium ion export (GO:0071436)4.82985526
5metanephric nephron tubule development (GO:0072234)4.50036818
6metanephric tubule development (GO:0072170)4.50036818
7potassium ion homeostasis (GO:0055075)4.43855014
8face development (GO:0060324)4.43293802
9collecting duct development (GO:0072044)4.42493874
10mesenchymal to epithelial transition involved in metanephros morphogenesis (GO:0003337)4.39071169
11lymph vessel development (GO:0001945)4.38827882
12definitive hemopoiesis (GO:0060216)4.34897737
13cranial nerve structural organization (GO:0021604)4.28447558
14axon ensheathment in central nervous system (GO:0032291)4.27103315
15central nervous system myelination (GO:0022010)4.27103315
16metanephric nephron epithelium development (GO:0072243)4.12103079
17nephron tubule formation (GO:0072079)4.02057907
18regulation of mammary gland epithelial cell proliferation (GO:0033599)4.01082529
19amino acid import (GO:0043090)3.91350284
20metanephric epithelium development (GO:0072207)3.88517320
21* anterior/posterior pattern specification (GO:0009952)3.73961235
22cellular potassium ion homeostasis (GO:0030007)3.67030784
23heterochromatin organization (GO:0070828)3.63780156
24mesenchymal cell differentiation involved in kidney development (GO:0072161)3.63592530
25mesenchymal cell differentiation involved in renal system development (GO:2001012)3.63592530
26protein retention in ER lumen (GO:0006621)3.62685418
27myelin maintenance (GO:0043217)3.62578181
28cytoskeletal anchoring at plasma membrane (GO:0007016)3.59698070
29negative regulation of catenin import into nucleus (GO:0035414)3.58666415
30potassium ion import (GO:0010107)3.56196810
31neuromuscular process controlling posture (GO:0050884)3.54843088
32cranial nerve morphogenesis (GO:0021602)3.52928176
33* skeletal system morphogenesis (GO:0048705)3.52068714
34maintenance of protein localization in endoplasmic reticulum (GO:0035437)3.46416914
35polarized epithelial cell differentiation (GO:0030859)3.43961465
36* embryonic organ morphogenesis (GO:0048562)3.40048589
37neurofilament cytoskeleton organization (GO:0060052)3.39845129
38pattern specification involved in kidney development (GO:0061004)3.35863611
39proximal/distal pattern formation (GO:0009954)3.34068186
40mammary gland development (GO:0030879)3.33874068
41anatomical structure arrangement (GO:0048532)3.33709470
42regulation of glucose import in response to insulin stimulus (GO:2001273)3.31602698
43cell communication by electrical coupling involved in cardiac conduction (GO:0086064)3.30992090
44regulation of apoptotic process involved in morphogenesis (GO:1902337)3.29107667
45regulation of establishment of planar polarity involved in neural tube closure (GO:0090178)3.28169208
46neural tube development (GO:0021915)3.27485425
47regulation of clathrin-mediated endocytosis (GO:2000369)3.25781787
48regulation of NFAT protein import into nucleus (GO:0051532)3.23562396
49metanephric mesenchyme development (GO:0072075)3.23137192
50nonribosomal peptide biosynthetic process (GO:0019184)3.22532180
51peripheral nervous system neuron development (GO:0048935)3.21746852
52nephron tubule development (GO:0072080)3.21020604
53glucocorticoid receptor signaling pathway (GO:0042921)3.20387272
54cell communication by electrical coupling (GO:0010644)3.19265933
55glutathione biosynthetic process (GO:0006750)3.18395383
56response to parathyroid hormone (GO:0071107)3.17462834
57nucleosome disassembly (GO:0006337)3.09537524
58protein-DNA complex disassembly (GO:0032986)3.09537524
59cellular sodium ion homeostasis (GO:0006883)3.08292489
60aminoglycoside antibiotic metabolic process (GO:0030647)3.07945995
61nuclear pore complex assembly (GO:0051292)3.07898330
62kidney mesenchyme development (GO:0072074)3.05454274
63lung-associated mesenchyme development (GO:0060484)3.01755373
64morphogenesis of an epithelial sheet (GO:0002011)3.01706714
65lysine metabolic process (GO:0006553)3.01027587
66lysine catabolic process (GO:0006554)3.01027587
67embryonic skeletal joint morphogenesis (GO:0060272)2.99516266
68positive regulation of synaptic transmission, dopaminergic (GO:0032226)2.98957279
69negative regulation of microtubule polymerization (GO:0031115)2.93462828
70convergent extension (GO:0060026)2.92832724
71glucocorticoid biosynthetic process (GO:0006704)2.92784761
72phosphate ion transport (GO:0006817)2.92689539
73regulation of metanephric nephron tubule epithelial cell differentiation (GO:0072307)2.92219041
74embryonic skeletal system development (GO:0048706)2.91584175
75facial nerve structural organization (GO:0021612)2.89349273
76negative regulation of sodium ion transport (GO:0010766)2.88923987
77skeletal muscle organ development (GO:0060538)2.86405877
78regulation of nephron tubule epithelial cell differentiation (GO:0072182)2.85581586
79anterior/posterior axis specification, embryo (GO:0008595)2.84449118
80negative regulation of metanephros development (GO:0072217)2.83795330
81neuron fate specification (GO:0048665)2.83378391
82axon extension involved in axon guidance (GO:0048846)2.82900950
83neuron projection extension involved in neuron projection guidance (GO:1902284)2.82900950
84semaphorin-plexin signaling pathway (GO:0071526)2.80516249
85synaptic vesicle maturation (GO:0016188)2.79658223
86membrane repolarization during cardiac muscle cell action potential (GO:0086013)2.79367688
87mitotic chromosome condensation (GO:0007076)2.79199148
88positive regulation of glomerulus development (GO:0090193)2.79059509
89diaphragm development (GO:0060539)2.78940184
90DNA unwinding involved in DNA replication (GO:0006268)2.78565342
91positive regulation of DNA-dependent DNA replication (GO:2000105)2.78493516
92fat-soluble vitamin catabolic process (GO:0042363)2.78051274
93vitamin catabolic process (GO:0009111)2.78051274
94peptidyl-tyrosine autophosphorylation (GO:0038083)2.77515848
95cysteine metabolic process (GO:0006534)2.76750775
96negative regulation of mRNA splicing, via spliceosome (GO:0048025)2.73947509
97regulation of stem cell maintenance (GO:2000036)2.73765997
98* embryonic skeletal system morphogenesis (GO:0048704)2.73730802
99renal absorption (GO:0070293)2.72815238
100C21-steroid hormone biosynthetic process (GO:0006700)2.72571013
101cerebellar Purkinje cell layer development (GO:0021680)2.71545188
102regulation of chromatin binding (GO:0035561)2.70429277
103regulation of RNA export from nucleus (GO:0046831)2.68902342
104renal system process involved in regulation of blood volume (GO:0001977)2.68818527
105somatic stem cell division (GO:0048103)2.68134072
106excretion (GO:0007588)2.67204091
107renal tubule development (GO:0061326)2.66579912
108mitotic sister chromatid cohesion (GO:0007064)2.66458835
109cell-cell junction maintenance (GO:0045217)2.66432254
110regulation of mesenchymal to epithelial transition involved in metanephros morphogenesis (GO:00033392.65698853
111negative regulation of cell size (GO:0045792)2.63887681
112nephron epithelium development (GO:0072009)2.63428270
113regulation of somitogenesis (GO:0014807)2.62603658
114mesenchymal to epithelial transition (GO:0060231)2.62463336
115respiratory tube development (GO:0030323)2.62241882
116myeloid cell homeostasis (GO:0002262)2.61965454
117outer ear morphogenesis (GO:0042473)2.61796819
118endothelial cell differentiation (GO:0045446)2.61634813
119regulation of mitotic spindle organization (GO:0060236)2.60795413
120response to mercury ion (GO:0046689)2.60656254
121dichotomous subdivision of an epithelial terminal unit (GO:0060600)2.60311763
122drug transmembrane transport (GO:0006855)2.60054087
123layer formation in cerebral cortex (GO:0021819)2.58999210
124embryonic heart tube development (GO:0035050)2.57911506
125outflow tract septum morphogenesis (GO:0003148)2.56877512
126neutral amino acid transport (GO:0015804)2.55691358
127neurotransmitter secretion (GO:0007269)2.54260145
128nuclear pore organization (GO:0006999)2.52956609
129regulation of mesenchymal cell apoptotic process (GO:2001053)2.52645438
130regulation of respiratory gaseous exchange by neurological system process (GO:0002087)2.52562083
131protein localization to microtubule (GO:0035372)2.51644056
132RNA stabilization (GO:0043489)2.50970006
133mRNA stabilization (GO:0048255)2.50970006
134membrane repolarization during action potential (GO:0086011)2.50056082
135positive regulation of gene expression, epigenetic (GO:0045815)2.49239683
136neurotransmitter transport (GO:0006836)2.49213897
137mammary gland epithelial cell differentiation (GO:0060644)2.48063230
138stress granule assembly (GO:0034063)2.47828333
139sodium ion homeostasis (GO:0055078)2.47801162
140positive regulation of calcium ion-dependent exocytosis (GO:0045956)2.47641469
141mating behavior (GO:0007617)2.47640357
142spinal cord development (GO:0021510)2.47330100
143activation of Rac GTPase activity (GO:0032863)2.47068736
144planar cell polarity pathway involved in neural tube closure (GO:0090179)2.46566346
145positive regulation of receptor biosynthetic process (GO:0010870)2.45670271
146hypotonic response (GO:0006971)2.45323580
147urate metabolic process (GO:0046415)2.44804294
148urogenital system development (GO:0001655)2.44214210
149Wnt signaling pathway, planar cell polarity pathway (GO:0060071)2.44034316
150* regionalization (GO:0003002)2.43763542
151establishment or maintenance of epithelial cell apical/basal polarity (GO:0045197)2.43602342
152body morphogenesis (GO:0010171)2.43591775
153positive regulation of branching involved in ureteric bud morphogenesis (GO:0090190)2.43282353
154cochlea morphogenesis (GO:0090103)2.43223276
155organ induction (GO:0001759)2.42413009
156endothelial cell chemotaxis (GO:0035767)2.42329940
157establishment of nucleus localization (GO:0040023)2.42186797
158apical protein localization (GO:0045176)2.41925734
159cell migration in hindbrain (GO:0021535)2.41854235
160macroautophagy (GO:0016236)2.41784041
161negative regulation of mesenchymal cell apoptotic process (GO:2001054)2.40919671
162renal system process involved in regulation of systemic arterial blood pressure (GO:0003071)2.40660213
163regulation of branching involved in ureteric bud morphogenesis (GO:0090189)2.40286406
164maternal placenta development (GO:0001893)2.39998323
165protein targeting to plasma membrane (GO:0072661)2.36542591
166membrane repolarization (GO:0086009)2.34824936

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1TP63_17297297_ChIP-ChIP_HaCaT_Human3.15265370
2E2F7_22180533_ChIP-Seq_HELA_Human3.02906023
3FOXM1_23109430_ChIP-Seq_U2OS_Human2.80606960
4* RNF2_18974828_ChIP-Seq_MESCs_Mouse2.60071500
5* EZH2_18974828_ChIP-Seq_MESCs_Mouse2.60071500
6TRIM28_21343339_ChIP-Seq_HEK293_Human2.58152471
7* EZH2_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse2.56116871
8ESR2_21235772_ChIP-Seq_MCF-7_Human2.35302552
9WT1_20215353_ChIP-ChIP_NEPHRON_PROGENITOR_Mouse2.32054851
10ZFP281_18757296_ChIP-ChIP_E14_Mouse2.28902985
11* JARID2_20075857_ChIP-Seq_MESCs_Mouse2.24659601
12STAT6_21828071_ChIP-Seq_BEAS2B_Human2.17087279
13SUZ12_18555785_ChIP-Seq_MESCs_Mouse2.16643624
14* JARID2_20064375_ChIP-Seq_MESCs_Mouse2.15804646
15* SUZ12_18692474_ChIP-Seq_MEFs_Mouse2.14698674
16* CBX2_27304074_Chip-Seq_ESCs_Mouse2.12149512
17ESR1_21235772_ChIP-Seq_MCF-7_Human2.11698747
18* EED_16625203_ChIP-ChIP_MESCs_Mouse2.10840584
19TP63_19390658_ChIP-ChIP_HaCaT_Human2.02199046
20* SUZ12_18692474_ChIP-Seq_MESCs_Mouse2.01360536
21* MTF2_20144788_ChIP-Seq_MESCs_Mouse1.95374452
22* EZH2_27304074_Chip-Seq_ESCs_Mouse1.94569365
23MYC_22102868_ChIP-Seq_BL_Human1.93703487
24PPARG_19300518_ChIP-PET_3T3-L1_Mouse1.92883889
25RARG_19884340_ChIP-ChIP_MEFs_Mouse1.91481927
26CDX2_20551321_ChIP-Seq_CACO-2_Human1.91098764
27ERG_21242973_ChIP-ChIP_JURKAT_Human1.90710121
28* SUZ12_18974828_ChIP-Seq_MESCs_Mouse1.89656438
29* SUZ12_16625203_ChIP-ChIP_MESCs_Mouse1.88516167
30* CDX2_19796622_ChIP-Seq_MESCs_Mouse1.87204105
31* SUZ12_27294783_Chip-Seq_ESCs_Mouse1.85416020
32ZFP281_27345836_Chip-Seq_ESCs_Mouse1.83095979
33* EZH2_27294783_Chip-Seq_ESCs_Mouse1.77970670
34KDM2B_26808549_Chip-Seq_K562_Human1.77888539
35TP53_20018659_ChIP-ChIP_R1E_Mouse1.76820823
36CLOCK_20551151_ChIP-Seq_293T_Human1.75839056
37* SUZ12_20075857_ChIP-Seq_MESCs_Mouse1.71483790
38IKZF1_21737484_ChIP-ChIP_HCT116_Human1.70496016
39LXR_22292898_ChIP-Seq_THP-1_Human1.67506744
40ESR1_20079471_ChIP-ChIP_T-47D_Human1.64307211
41DNAJC2_21179169_ChIP-ChIP_NT2_Human1.61624509
42RACK7_27058665_Chip-Seq_MCF-7_Human1.61378649
43EP300_20729851_ChIP-Seq_FORBRAIN_MIDBRAIN_LIMB_HEART_Mouse1.61263668
44* RING1B_27294783_Chip-Seq_ESCs_Mouse1.59999134
45DROSHA_22980978_ChIP-Seq_HELA_Human1.59202289
46TBP_23326641_ChIP-Seq_C3H10T1-2_Mouse1.56729748
47* PHC1_16625203_ChIP-ChIP_MESCs_Mouse1.55834472
48TFAP2C_20629094_ChIP-Seq_MCF-7_Human1.54846464
49* KDM2B_26808549_Chip-Seq_SUP-B15_Human1.54027528
50VDR_21846776_ChIP-Seq_THP-1_Human1.53213197
51TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat1.52167941
52TCF7_22412390_ChIP-Seq_EML_Mouse1.50081354
53CHD7_19251738_ChIP-ChIP_MESCs_Mouse1.49826857
54EGR1_19374776_ChIP-ChIP_THP-1_Human1.48181590
55TET1_21451524_ChIP-Seq_MESCs_Mouse1.47905925
56RNF2_27304074_Chip-Seq_ESCs_Mouse1.47137449
57* RING1B_27294783_Chip-Seq_NPCs_Mouse1.46922328
58TCF3_18467660_ChIP-ChIP_MESCs_Mouse1.44187117
59P300_27058665_Chip-Seq_ZR-75-30cells_Human1.43149665
60EGR1_20690147_ChIP-Seq_ERYTHROLEUKEMIA_Human1.42029699
61THRA_23701648_ChIP-Seq_CEREBELLUM_Mouse1.41475366
62KLF4_19030024_ChIP-ChIP_MESCs_Mouse1.40768918
63ZFP281_18358816_ChIP-ChIP_MESCs_Mouse1.39513886
64KLF5_18264089_ChIP-ChIP_MESCs_Mouse1.35889124
65KLF4_18264089_ChIP-ChIP_MESCs_Mouse1.35889124
66KLF2_18264089_ChIP-ChIP_MESCs_Mouse1.35889124
67CREB1_23762244_ChIP-Seq_HIPPOCAMPUS_Rat1.35578635
68MYBL1_21750041_ChIP-ChIP_SPERMATOCYTES_Mouse1.35491240
69CREB1_26743006_Chip-Seq_LNCaP-abl_Human1.33713035
70DMRT1_23473982_ChIP-Seq_TESTES_Mouse1.32833552
71* WT1_25993318_ChIP-Seq_PODOCYTE_Human1.32287905
72ESR1_22446102_ChIP-Seq_UTERUS_Mouse1.29976392
73* ELK3_25401928_ChIP-Seq_HUVEC_Human1.29449505
74NANOG_18700969_ChIP-ChIP_MESCs_Mouse1.26766988
75KDM2B_26808549_Chip-Seq_DND41_Human1.26593828
76NR4A2_19515692_ChIP-ChIP_MN9D_Mouse1.26174373
77EZH2_22144423_ChIP-Seq_EOC_Human1.25382105
78* RNF2_16625203_ChIP-ChIP_MESCs_Mouse1.24256524
79FOXM1_25889361_ChIP-Seq_OE33_AND_U2OS_Human1.22894030
80* RNF2_27304074_Chip-Seq_NSC_Mouse1.22429910
81* KDM2B_26808549_Chip-Seq_JURKAT_Human1.20988994
82MYCN_19997598_ChIP-ChIP_NEUROBLASTOMA_Human1.20623036
83CREB1_20920259_ChIP-Seq_GC1-SPG_Mouse1.18800354
84* STAT3_19079543_ChIP-ChIP_MESCs_Mouse1.17779054
85SMAD3_22036565_ChIP-Seq_ESCs_Mouse1.16053611
86OLIG2_26023283_ChIP-Seq_AINV15_Mouse1.13633204
87ZFP322A_24550733_ChIP-Seq_MESCs_Mouse1.13523163
88KLF4_18358816_ChIP-ChIP_MESCs_Mouse1.13449621
89ESR1_15608294_ChIP-ChIP_MCF-7_Human1.13446007
90ZNF263_19887448_ChIP-Seq_K562_Human1.13300798
91RCOR2_21632747_ChIP-Seq_MESCs_Mouse1.12864180
92AR_21909140_ChIP-Seq_LNCAP_Human1.12147439
93CCND1_20090754_ChIP-ChIP_RETINA_Mouse1.11863518
94* KDM5B_21448134_ChIP-Seq_MESCs_Mouse1.11789593
95* SA1_27219007_Chip-Seq_ERYTHROID_Human1.10562479
96KLF6_26769127_Chip-Seq_PDAC-Cell_line_Human1.09363498
97DACH1_20351289_ChIP-Seq_MDA-MB-231_Human1.09287742
98HCFC1_20581084_ChIP-Seq_MESCs_Mouse1.08556720
99CREB1_26743006_Chip-Seq_LNCaP_Human1.07724627
100KDM2B_26808549_Chip-Seq_HPB-ALL_Human1.07353557
101XRN2_22483619_ChIP-Seq_HELA_Human1.05819113
102RUNX2_24764292_ChIP-Seq_MC3T3_Mouse1.05738317
103NUCKS1_24931609_ChIP-Seq_HEPATOCYTES_Mouse1.05490693
104* BMI1_23680149_ChIP-Seq_NPCS_Mouse1.03123615
105KLF4_26769127_Chip-Seq_PDAC-Cell_line_Human1.02317249
106ATF3_27146783_Chip-Seq_COLON_Human1.02217270
107UBF1/2_26484160_Chip-Seq_HMEC-DERIVED_Human1.02185295
108CTNNB1_20615089_ChIP-ChIP_FETAL_BRAIN_Human1.02031285
109* SMC4_20622854_ChIP-Seq_HELA_Human1.01663378
110KDM2B_26808549_Chip-Seq_SIL-ALL_Human1.01657213
111ESRRB_18555785_ChIP-Seq_MESCs_Mouse1.00806510
112SMARCA4_20176728_ChIP-ChIP_TSCs_Mouse1.00080132
113TCF21_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human0.99637028
114ELF3_26769127_Chip-Seq_PDAC-Cell_line_Human0.99207147
115MYCN_27167114_Chip-Seq_NEUROBLASTOMA_Human0.98834440
116* CTCF_27219007_Chip-Seq_Bcells_Human0.97377344
117GATA3_20176728_ChIP-ChIP_TSCs_Mouse0.96590893
118TFAP2A_17053090_ChIP-ChIP_MCF-7_Human0.95634500
119RUNX1_27514584_Chip-Seq_MCF-7_Human0.95378385
120ERA_27197147_Chip-Seq_ENDOMETRIOID-ADENOCARCINOMA_Human0.94949324
121* P68_20966046_ChIP-Seq_HELA_Human0.94725237
122NFIB_24661679_ChIP-Seq_LUNG_Mouse0.94303003
123TP53_22127205_ChIP-Seq_IMR90_Human0.93664902
124KLF5_25053715_ChIP-Seq_YYC3_Human0.93312541
125SALL4_18804426_ChIP-ChIP_MESCs_Mouse0.93039470
126EP300_21415370_ChIP-Seq_HL-1_Mouse0.93014821
127SOX9_25088423_ChIP-ChIP_EMBRYONIC_GONADS_Mouse0.91219149
128* CTCF_27219007_Chip-Seq_ERYTHROID_Human0.91052085
129RARB_27405468_Chip-Seq_BRAIN_Mouse0.90592698

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0004885_abnormal_endolymph3.43823859
2MP0005623_abnormal_meninges_morphology3.27119859
3MP0000534_abnormal_ureter_morphology3.06850514
4MP0004043_abnormal_pH_regulation3.05187343
5MP0000678_abnormal_parathyroid_gland2.79963099
6MP0002877_abnormal_melanocyte_morpholog2.68455036
7MP0003385_abnormal_body_wall2.62074496
8MP0000537_abnormal_urethra_morphology2.61717073
9MP0003705_abnormal_hypodermis_morpholog2.42290232
10MP0005076_abnormal_cell_differentiation2.37086528
11MP0003122_maternal_imprinting2.35441426
12MP0001765_abnormal_ion_homeostasis2.27918695
13MP0003880_abnormal_central_pattern2.23261978
14MP0005409_darkened_coat_color2.16851648
15MP0001188_hyperpigmentation2.16301158
16MP0000681_abnormal_thyroid_gland2.16198479
17MP0003942_abnormal_urinary_system2.07840009
18MP0004858_abnormal_nervous_system2.06771260
19MP0001756_abnormal_urination2.04475305
20MP0003123_paternal_imprinting2.03931082
21MP0010234_abnormal_vibrissa_follicle1.98363960
22MP0008961_abnormal_basal_metabolism1.82241166
23MP0003329_amyloid_beta_deposits1.81595273
24MP0005377_hearing/vestibular/ear_phenot1.79521910
25MP0003878_abnormal_ear_physiology1.79521910
26MP0002822_catalepsy1.77401240
27MP0001346_abnormal_lacrimal_gland1.77099643
28MP0004233_abnormal_muscle_weight1.74983775
29MP0004272_abnormal_basement_membrane1.74518078
30MP0004142_abnormal_muscle_tone1.72850681
31MP0003283_abnormal_digestive_organ1.69524488
32MP0005670_abnormal_white_adipose1.68944418
33MP0009250_abnormal_appendicular_skeleto1.68751568
34MP0003690_abnormal_glial_cell1.67183097
35MP0001958_emphysema1.65548900
36MP0004185_abnormal_adipocyte_glucose1.63676392
37MP0001879_abnormal_lymphatic_vessel1.63593822
38MP0002909_abnormal_adrenal_gland1.54769293
39MP0005360_urolithiasis1.53234273
40MP0009643_abnormal_urine_homeostasis1.52329086
41MP0004859_abnormal_synaptic_plasticity1.51548136
42MP0000049_abnormal_middle_ear1.48566882
43MP0002932_abnormal_joint_morphology1.45710198
44MP0001849_ear_inflammation1.45538909
45MP0009053_abnormal_anal_canal1.44297783
46MP0003119_abnormal_digestive_system1.44196788
47MP0000920_abnormal_myelination1.41836964
48MP0004019_abnormal_vitamin_homeostasis1.39529157
49MP0000516_abnormal_urinary_system1.39142845
50MP0005367_renal/urinary_system_phenotyp1.39142845
51MP0003111_abnormal_nucleus_morphology1.38257597
52MP0000538_abnormal_urinary_bladder1.37190990
53MP0002184_abnormal_innervation1.36604979
54MP0003195_calcinosis1.35350652
55MP0000566_synostosis1.34408744
56MP0002249_abnormal_larynx_morphology1.33437261
57MP0003635_abnormal_synaptic_transmissio1.32877964
58MP0000462_abnormal_digestive_system1.31745435
59MP0010030_abnormal_orbit_morphology1.30718363
60MP0002697_abnormal_eye_size1.30670617
61MP0003861_abnormal_nervous_system1.30661255
62MP0004782_abnormal_surfactant_physiolog1.28824344
63* MP0000955_abnormal_spinal_cord1.27272319
64MP0000751_myopathy1.26264932
65MP0002234_abnormal_pharynx_morphology1.26114756
66MP0003693_abnormal_embryo_hatching1.24950893
67MP0002085_abnormal_embryonic_tissue1.24024625
68MP0002116_abnormal_craniofacial_bone1.23739943
69MP0005332_abnormal_amino_acid1.20844082
70MP0008438_abnormal_cutaneous_collagen1.20476036
71MP0005257_abnormal_intraocular_pressure1.20390860
72MP0005636_abnormal_mineral_homeostasis1.20085933
73MP0002089_abnormal_postnatal_growth/wei1.19315417
74MP0001486_abnormal_startle_reflex1.19078464
75MP0002136_abnormal_kidney_physiology1.18765973
76MP0000778_abnormal_nervous_system1.16974451
77MP0009780_abnormal_chondrocyte_physiolo1.16434078
78MP0000747_muscle_weakness1.14292187
79MP0002081_perinatal_lethality1.14004281
80MP0005167_abnormal_blood-brain_barrier1.13747933
81MP0001730_embryonic_growth_arrest1.13095936
82* MP0002114_abnormal_axial_skeleton1.11646651
83MP0009672_abnormal_birth_weight1.11010783
84MP0003077_abnormal_cell_cycle1.10940848
85MP0002064_seizures1.10154415
86MP0010368_abnormal_lymphatic_system1.09588291
87MP0002896_abnormal_bone_mineralization1.06691603
88MP0000003_abnormal_adipose_tissue1.06312034
89MP0002282_abnormal_trachea_morphology1.05912813
90MP0008932_abnormal_embryonic_tissue1.05098181
91MP0000350_abnormal_cell_proliferation1.04310025
92MP0002092_abnormal_eye_morphology1.04172600
93MP0003935_abnormal_craniofacial_develop1.03731214
94MP0002796_impaired_skin_barrier1.03616657
95MP0004270_analgesia1.03579864
96MP0002735_abnormal_chemical_nociception1.03563234
97MP0001286_abnormal_eye_development1.03244580
98* MP0003634_abnormal_glial_cell1.01968341
99MP0008569_lethality_at_weaning1.01224550
100MP0004742_abnormal_vestibular_system1.00180658
101MP0005375_adipose_tissue_phenotype1.00108258
102MP0001299_abnormal_eye_distance/0.98897047
103MP0009046_muscle_twitch0.98604004
104MP0002084_abnormal_developmental_patter0.98190826
105MP0003755_abnormal_palate_morphology0.97797295
106MP0003300_gastrointestinal_ulcer0.97349964
107MP0005508_abnormal_skeleton_morphology0.97322290
108MP0010307_abnormal_tumor_latency0.97224368
109MP0001943_abnormal_respiration0.96821591
110MP0003115_abnormal_respiratory_system0.96616154
111MP0002177_abnormal_outer_ear0.96546134
112MP0005503_abnormal_tendon_morphology0.96502760
113MP0005058_abnormal_lysosome_morphology0.96017316
114MP0001672_abnormal_embryogenesis/_devel0.94330974
115MP0005380_embryogenesis_phenotype0.94330974
116MP0005645_abnormal_hypothalamus_physiol0.93859679
117MP0000733_abnormal_muscle_development0.93753381
118MP0010352_gastrointestinal_tract_polyps0.92035454
119MP0000428_abnormal_craniofacial_morphol0.91153303
120* MP0000432_abnormal_head_morphology0.90951081
121MP0000759_abnormal_skeletal_muscle0.90622811
122* MP0002733_abnormal_thermal_nociception0.90514233
123MP0001348_abnormal_lacrimal_gland0.90078947
124MP0003984_embryonic_growth_retardation0.87889576
125MP0004197_abnormal_fetal_growth/weight/0.86785588
126MP0002111_abnormal_tail_morphology0.86257924
127MP0009278_abnormal_bone_marrow0.85087054
128MP0003943_abnormal_hepatobiliary_system0.84366685
129MP0005423_abnormal_somatic_nervous0.84303012
130MP0003938_abnormal_ear_development0.84146919
131MP0003632_abnormal_nervous_system0.83974020
132MP0000762_abnormal_tongue_morphology0.83439480
133MP0002653_abnormal_ependyma_morphology0.83038494
134MP0001664_abnormal_digestion0.82734516
135MP0005666_abnormal_adipose_tissue0.82678845
136* MP0002067_abnormal_sensory_capabilities0.82619082
137MP0000467_abnormal_esophagus_morphology0.82505340
138MP0010094_abnormal_chromosome_stability0.81927938
139MP0008770_decreased_survivor_rate0.81566541
140MP0002108_abnormal_muscle_morphology0.81059800
141MP0001485_abnormal_pinna_reflex0.80941997
142MP0001270_distended_abdomen0.79550371
143MP0004957_abnormal_blastocyst_morpholog0.79483790
144MP0002080_prenatal_lethality0.78863522
145MP0010678_abnormal_skin_adnexa0.78376669
146MP0002086_abnormal_extraembryonic_tissu0.78368861
147MP0002088_abnormal_embryonic_growth/wei0.78064216
148MP0002734_abnormal_mechanical_nocicepti0.77877046
149MP0002925_abnormal_cardiovascular_devel0.77707308
150MP0002135_abnormal_kidney_morphology0.74831752
151MP0005275_abnormal_skin_tensile0.74812218
152* MP0002066_abnormal_motor_capabilities/c0.74791734
153MP0000013_abnormal_adipose_tissue0.74661054
154MP0002272_abnormal_nervous_system0.72351418
155MP0003638_abnormal_response/metabolism_0.72337325
156MP0003937_abnormal_limbs/digits/tail_de0.71630999
157MP0002115_abnormal_skeleton_extremities0.71169936
158MP0003566_abnormal_cell_adhesion0.71043860
159MP0002882_abnormal_neuron_morphology0.70489646
160MP0003959_abnormal_lean_body0.70396902
161MP0004811_abnormal_neuron_physiology0.70169957
162MP0003633_abnormal_nervous_system0.70019299
163MP0000579_abnormal_nail_morphology0.69240373

Predicted human phenotypes

RankGene SetZ-score
1Increased circulating renin level (HP:0000848)6.92286783
2Metabolic alkalosis (HP:0200114)5.39568012
3Hypokalemic alkalosis (HP:0001949)4.85084520
4Renal salt wasting (HP:0000127)4.68443857
5Hypomagnesemia (HP:0002917)4.38374218
6Abnormality of renin-angiotensin system (HP:0000847)4.06769769
7Genetic anticipation (HP:0003743)4.05889003
8Hyperaldosteronism (HP:0000859)3.97445325
9Polyuria (HP:0000103)3.93168996
10Abnormality of magnesium homeostasis (HP:0004921)3.85710272
11Abnormal urine output (HP:0012590)3.83487039
12Supranuclear gaze palsy (HP:0000605)3.79859668
13Facial shape deformation (HP:0011334)3.70476051
14Potter facies (HP:0002009)3.70476051
15Polydipsia (HP:0001959)3.52742962
16Abnormal drinking behavior (HP:0030082)3.52742962
17Gout (HP:0001997)3.42303361
18Abnormality of renal excretion (HP:0011036)3.38985339
19Dysmetric saccades (HP:0000641)3.36885928
20Abnormality of chloride homeostasis (HP:0011422)3.29814111
21Hyperactive renin-angiotensin system (HP:0000841)3.28742783
22Abnormality of the aortic arch (HP:0012303)3.23727629
23Hypercalciuria (HP:0002150)3.13739450
24Hypokalemia (HP:0002900)3.13638377
25Muscle stiffness (HP:0003552)3.12654382
26Adrenal overactivity (HP:0002717)2.95617523
27Abnormality of the phalanges of the hallux (HP:0010057)2.89131462
28Urethral obstruction (HP:0000796)2.78436007
29Renal duplication (HP:0000075)2.75661997
30Bicornuate uterus (HP:0000813)2.74238951
31Alkalosis (HP:0001948)2.73766052
32Elfin facies (HP:0004428)2.68876284
33Hyperacusis (HP:0010780)2.65724652
34Abnormality of the distal phalanx of the thumb (HP:0009617)2.63714502
35Abnormality of potassium homeostasis (HP:0011042)2.60680765
36Truncus arteriosus (HP:0001660)2.57004515
37Abnormality of the fingertips (HP:0001211)2.56906065
38Glomerulosclerosis (HP:0000096)2.56223561
39Increased nuchal translucency (HP:0010880)2.53896788
40Focal segmental glomerulosclerosis (HP:0000097)2.53326091
41High anterior hairline (HP:0009890)2.53027309
42Insomnia (HP:0100785)2.51338914
43Cerebral aneurysm (HP:0004944)2.47449817
44Broad face (HP:0000283)2.46937729
45Hyperparathyroidism (HP:0000843)2.39676741
46Slow saccadic eye movements (HP:0000514)2.38972913
47Septate vagina (HP:0001153)2.35476152
48Obstructive sleep apnea (HP:0002870)2.35002993
49Patellar dislocation (HP:0002999)2.33507492
50Abnormal number of incisors (HP:0011064)2.31614773
51Unilateral renal agenesis (HP:0000122)2.31072918
52Intestinal fistula (HP:0100819)2.29801898
53Overriding aorta (HP:0002623)2.27610651
54Neoplasm of the heart (HP:0100544)2.26967790
55Abnormality of the diencephalon (HP:0010662)2.24421652
56Tetany (HP:0001281)2.22291270
57Shallow orbits (HP:0000586)2.20594913
58Broad metatarsal (HP:0001783)2.19922639
59Obsessive-compulsive behavior (HP:0000722)2.19693090
60Long palpebral fissure (HP:0000637)2.17936117
61Enlarged penis (HP:0000040)2.16769865
62Hyperthyroidism (HP:0000836)2.15903172
63Optic nerve coloboma (HP:0000588)2.15145006
64Shawl scrotum (HP:0000049)2.14655756
65Arnold-Chiari malformation (HP:0002308)2.11841882
66Atelectasis (HP:0100750)2.10561862
67Long eyelashes (HP:0000527)2.09128894
68Increased purine levels (HP:0004368)2.08675505
69Hyperuricemia (HP:0002149)2.08675505
70Thin bony cortex (HP:0002753)2.08072386
71Elevated circulating parathyroid hormone (PTH) level (HP:0003165)2.04810106
72Disproportionate tall stature (HP:0001519)2.04529498
73Trigonocephaly (HP:0000243)2.03711392
74Hypoplasia of the iris (HP:0007676)2.03668171
75Ectopic kidney (HP:0000086)2.03057435
76Lymphangioma (HP:0100764)2.01207800
77Peripheral hypomyelination (HP:0007182)1.98895111
78Turricephaly (HP:0000262)1.98472368
79Abnormal eating behavior (HP:0100738)1.97974283
80Self-mutilation (HP:0000742)1.96847330
81Back pain (HP:0003418)1.96111890
82Abnormality of sodium homeostasis (HP:0010931)1.95882406
83Down-sloping shoulders (HP:0200021)1.94144182
84Hypercortisolism (HP:0001578)1.93789721
85Hypoventilation (HP:0002791)1.92948938
86Bladder diverticulum (HP:0000015)1.92387773
87Vesicoureteral reflux (HP:0000076)1.90437870
88Nephrolithiasis (HP:0000787)1.89267796
89Abnormal umbilical cord blood vessels (HP:0011403)1.87995111
90Single umbilical artery (HP:0001195)1.87995111
91Abnormality of the fetal cardiovascular system (HP:0010948)1.87995111
92Precocious puberty (HP:0000826)1.87916736
93Bowel incontinence (HP:0002607)1.87302424
94Protrusio acetabuli (HP:0003179)1.86009042
95Ankle clonus (HP:0011448)1.85567758
96Myokymia (HP:0002411)1.85332373
97Buphthalmos (HP:0000557)1.84544821
98Renal dysplasia (HP:0000110)1.84374391
99Aortic aneurysm (HP:0004942)1.84139891
100Ankyloglossia (HP:0010296)1.83641157
101Double outlet right ventricle (HP:0001719)1.82063569
102Congenital malformation of the right heart (HP:0011723)1.82063569
103Germ cell neoplasia (HP:0100728)1.81797266
104Transposition of the great arteries (HP:0001669)1.81558769
105Abnormal connection of the cardiac segments (HP:0011545)1.81558769
106Abnormal ventriculo-arterial connection (HP:0011563)1.81558769
107Abnormality of chromosome segregation (HP:0002916)1.80692171
108Intracellular accumulation of autofluorescent lipopigment storage material (HP:0003204)1.79306778
109Upper limb amyotrophy (HP:0009129)1.78852776
110Distal upper limb amyotrophy (HP:0007149)1.78852776
111Neonatal onset (HP:0003623)1.78785726
112Oligodontia (HP:0000677)1.78696187
113Short 5th finger (HP:0009237)1.78145933
114Abnormality of glutamine family amino acid metabolism (HP:0010902)1.77880928
115Broad distal phalanx of finger (HP:0009836)1.76934510
116Scapular winging (HP:0003691)1.76339699
117Hypercalcemia (HP:0003072)1.76216930
118Abnormal large intestine physiology (HP:0012700)1.75736447
119Renovascular hypertension (HP:0100817)1.75662723
120Insidious onset (HP:0003587)1.75594057
121Termporal pattern (HP:0011008)1.75594057
122Cerebral inclusion bodies (HP:0100314)1.75366450
123Abnormality of the columella (HP:0009929)1.75007661
124Premature rupture of membranes (HP:0001788)1.73534964
125Urinary urgency (HP:0000012)1.73212339
126Attention deficit hyperactivity disorder (HP:0007018)1.72631351
127Anal stenosis (HP:0002025)1.71802575
128Long toe (HP:0010511)1.71751605
129Atresia of the external auditory canal (HP:0000413)1.70543811
130Megalocornea (HP:0000485)1.70257920
131Stridor (HP:0010307)1.69906117
132Coronal craniosynostosis (HP:0004440)1.69631113
133Frequent falls (HP:0002359)1.69585344
134Nephrocalcinosis (HP:0000121)1.69248086
135Aplasia/Hypoplasia of the 4th metacarpal (HP:0010042)1.68789934
136Short 4th metacarpal (HP:0010044)1.68789934
137Flat cornea (HP:0007720)1.67975060
138Hand muscle atrophy (HP:0009130)1.67837613
139Spina bifida occulta (HP:0003298)1.67214665
140Abnormality of the intervertebral disk (HP:0005108)1.66779439
141Exotropia (HP:0000577)1.65927016
142Abnormality of the parietal bone (HP:0002696)1.65897991
143Flat acetabular roof (HP:0003180)1.65666647
144Pointed chin (HP:0000307)1.65405090
145Action tremor (HP:0002345)1.64173023
146Segmental peripheral demyelination/remyelination (HP:0003481)1.64168031
147Macroorchidism (HP:0000053)1.63411464
148Dysautonomia (HP:0002459)1.63374724
149Bell-shaped thorax (HP:0001591)1.63355993
150Limb-girdle muscle atrophy (HP:0003797)1.62953401
151Aplasia/Hypoplasia of the 5th finger (HP:0006262)1.62854460
152Abnormality of purine metabolism (HP:0004352)1.62050155
153Bowel diverticulosis (HP:0005222)1.61665536
154Abnormality of cochlea (HP:0000375)1.61495324
155Aplasia involving bones of the upper limbs (HP:0009823)1.61455645
156Aplasia of the phalanges of the hand (HP:0009802)1.61455645
157Aplasia involving bones of the extremities (HP:0009825)1.61455645
158Aortic dissection (HP:0002647)1.61331041
159Fragile skin (HP:0001030)1.61159725
160Atrophic scars (HP:0001075)1.60857323
161Proximal placement of thumb (HP:0009623)1.60243326
162Aplasia/Hypoplasia of the pubic bone (HP:0009104)1.60141453
163Horseshoe kidney (HP:0000085)1.59377300
164Abnormality of binocular vision (HP:0011514)1.59233928
165Diplopia (HP:0000651)1.59233928
166Mildly elevated creatine phosphokinase (HP:0008180)1.59219336
167Hydroxyprolinuria (HP:0003080)1.59043097
168Abnormality of proline metabolism (HP:0010907)1.59043097
169Abnormality of the Achilles tendon (HP:0005109)1.58869824
170Impaired smooth pursuit (HP:0007772)1.58666055
171Deep palmar crease (HP:0006191)1.58501119
172Achilles tendon contracture (HP:0001771)1.58053746
173Annular pancreas (HP:0001734)1.57747878
174Abnormality of the distal phalanges of the toes (HP:0010182)1.57690766
175Heterotopia (HP:0002282)1.57684656
176Ureteral stenosis (HP:0000071)1.57572986
177Deviation of the hallux (HP:0010051)1.55717655
178Abnormality of the 4th metacarpal (HP:0010012)1.55658794
179Intention tremor (HP:0002080)1.55365183
180Ulnar bowing (HP:0003031)1.54907166

Predicted kinase interactions (KEA)

RankGene SetZ-score
1WNK44.21163564
2WNK13.71738723
3OXSR13.34841566
4MST1R3.30188301
5WNK32.90367472
6LIMK12.83436337
7TRIB32.78595669
8EPHA22.76516303
9STK392.75300831
10LMTK22.24350253
11SMG12.19963961
12LATS22.09423190
13MAP3K102.03975323
14IRAK32.02036807
15UHMK11.97094811
16STK381.95118023
17MINK11.81130759
18AKT31.74482813
19EEF2K1.61745145
20CDK121.55045041
21PRPF4B1.51550444
22LRRK21.46959229
23FER1.45568874
24NEK21.45002403
25PKN21.44560292
26PDGFRA1.44530924
27CAMK1G1.43188066
28PRKD31.42493758
29PTK61.40085916
30PAK61.39409931
31SIK31.37598647
32ROCK21.36260583
33MAP2K41.36052465
34BMX1.33257901
35MAP3K41.33140293
36NEK11.32095115
37NTRK11.28015979
38ALK1.23704688
39SGK4941.19894277
40SGK2231.19894277
41PAK21.19687675
42CAMKK11.14427608
43PTK21.13403539
44SCYL21.13013877
45CDK81.11386915
46EPHB21.09941928
47TESK11.08246456
48PAK31.08121037
49ERN11.06848680
50LATS11.03348257
51MAP3K91.02005656
52KSR21.01810411
53NTRK31.00651079
54PRKG20.95216784
55SIK10.93868093
56TTN0.92923557
57TYRO30.92184392
58CDC70.92021090
59RET0.91849904
60TAOK10.88063814
61CDK190.87100727
62RIPK10.86688867
63CHEK20.86655564
64ILK0.86595324
65FGFR20.86576062
66ROCK10.85996959
67CAMK1D0.85913211
68PHKG10.84839779
69PHKG20.84839779
70CDK70.84160367
71ICK0.83546035
72CDK90.82818669
73CDC42BPA0.81861602
74PRKD10.81309248
75PASK0.79891516
76TNK20.79139143
77MAP3K120.79070498
78MARK20.78501629
79MYLK0.77623656
80DDR20.76952638
81PRKCH0.75988380
82MARK10.75109208
83CHEK10.74068187
84KSR10.73258426
85KDR0.71984196
86MAP3K20.70720366
87EPHB10.67334179
88NME20.67042351
89PINK10.66940593
90CDK40.66591647
91STK110.66269810
92PAK40.66181693
93PNCK0.66068234
94PDK20.65404509
95MAP2K20.64118709
96MTOR0.63706762
97BRSK10.61980629
98BUB10.59643750
99CDK20.58544189
100MKNK20.58262678
101PRKAA10.57849599
102SGK30.57536101
103CDK10.55446906
104CSNK1E0.53912631
105MAP3K80.53117864
106CDK140.52743559
107FGFR10.52260335
108EIF2AK10.52118508
109PRKCI0.51256763
110MET0.50010381
111TTK0.49210140
112ATR0.48418160
113CAMK2G0.48416569
114CSNK1G30.48193067
115MELK0.47700236
116MAP3K60.47350815
117CSNK1G20.46987297
118IRAK20.46180285
119DYRK20.46024221
120PAK10.45045167
121NTRK20.44533220
122ERBB20.43847597
123TESK20.43316375
124MAP3K70.42821879
125BRD40.42193700
126CSNK1A1L0.41713069
127RPS6KA20.41637677
128CDK150.41324010
129SIK20.40401402
130ERBB40.40001143
131DYRK30.39760533
132MKNK10.39503382
133CDK50.39170458
134SRC0.39113856
135GSK3B0.38780985
136MAPK130.38731977
137PRKCZ0.38474838
138AKT20.38401730
139MAPK80.37908828
140GSK3A0.37742601
141MAPKAPK50.37421084
142CDK11A0.37366883
143MAP3K110.36745200
144NME10.35002022
145CDK180.34098214
146ERBB30.33926555
147BRAF0.32113976
148PRKD20.32065395
149RPS6KB20.31571507
150MAPK140.31282500
151TAOK20.30439028

Predicted pathways (KEGG)

RankGene SetZ-score
1Nitrogen metabolism_Homo sapiens_hsa009104.10395873
2Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa049613.16179440
3Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049643.15087697
4Vasopressin-regulated water reabsorption_Homo sapiens_hsa049622.67265605
5Cyanoamino acid metabolism_Homo sapiens_hsa004602.58480049
6Notch signaling pathway_Homo sapiens_hsa043302.30523381
7Synaptic vesicle cycle_Homo sapiens_hsa047212.04542829
82-Oxocarboxylic acid metabolism_Homo sapiens_hsa012101.97138150
9Bile secretion_Homo sapiens_hsa049761.89783867
10Gastric acid secretion_Homo sapiens_hsa049711.80787267
11Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa049601.80480327
12Pancreatic cancer_Homo sapiens_hsa052121.79762642
13Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010401.73418903
14Adherens junction_Homo sapiens_hsa045201.71014080
15Synthesis and degradation of ketone bodies_Homo sapiens_hsa000721.69122405
16mRNA surveillance pathway_Homo sapiens_hsa030151.62833758
17Colorectal cancer_Homo sapiens_hsa052101.60408455
18Thyroid cancer_Homo sapiens_hsa052161.59003250
19Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006301.56352532
20Taurine and hypotaurine metabolism_Homo sapiens_hsa004301.54306721
21Non-small cell lung cancer_Homo sapiens_hsa052231.54205884
22Butanoate metabolism_Homo sapiens_hsa006501.50191718
23MicroRNAs in cancer_Homo sapiens_hsa052061.45004109
24Citrate cycle (TCA cycle)_Homo sapiens_hsa000201.42355068
25Cell cycle_Homo sapiens_hsa041101.41201452
26Longevity regulating pathway - multiple species_Homo sapiens_hsa042131.38890510
27Hedgehog signaling pathway_Homo sapiens_hsa043401.35662976
28Mineral absorption_Homo sapiens_hsa049781.31415470
29Propanoate metabolism_Homo sapiens_hsa006401.27048295
30Nicotine addiction_Homo sapiens_hsa050331.24269517
31Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002501.23945201
32Choline metabolism in cancer_Homo sapiens_hsa052311.22919004
33Longevity regulating pathway - mammal_Homo sapiens_hsa042111.21831017
34Cholinergic synapse_Homo sapiens_hsa047251.20308536
35Protein digestion and absorption_Homo sapiens_hsa049741.16815198
36Tight junction_Homo sapiens_hsa045301.15256586
37Fatty acid metabolism_Homo sapiens_hsa012121.13433509
38Valine, leucine and isoleucine degradation_Homo sapiens_hsa002801.12589966
39Collecting duct acid secretion_Homo sapiens_hsa049661.11476490
40Basal cell carcinoma_Homo sapiens_hsa052171.11252307
41mTOR signaling pathway_Homo sapiens_hsa041501.10965083
42Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005121.10219695
43Axon guidance_Homo sapiens_hsa043601.09660561
44Hippo signaling pathway_Homo sapiens_hsa043901.09317200
45Thyroid hormone synthesis_Homo sapiens_hsa049181.08340188
46Vibrio cholerae infection_Homo sapiens_hsa051101.08264759
47Salivary secretion_Homo sapiens_hsa049701.06105477
48Pyruvate metabolism_Homo sapiens_hsa006201.05809136
49Type II diabetes mellitus_Homo sapiens_hsa049301.04900267
50Aldosterone synthesis and secretion_Homo sapiens_hsa049251.03340459
51Acute myeloid leukemia_Homo sapiens_hsa052211.03266447
52Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004001.02745667
53Sulfur metabolism_Homo sapiens_hsa009201.02147311
54DNA replication_Homo sapiens_hsa030301.00762562
55Adrenergic signaling in cardiomyocytes_Homo sapiens_hsa042610.98985609
56Regulation of lipolysis in adipocytes_Homo sapiens_hsa049230.98255103
57Proteoglycans in cancer_Homo sapiens_hsa052050.97807701
58AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa049330.96330859
59Spliceosome_Homo sapiens_hsa030400.95580793
60Bacterial invasion of epithelial cells_Homo sapiens_hsa051000.90982274
61Prostate cancer_Homo sapiens_hsa052150.90650392
62Sulfur relay system_Homo sapiens_hsa041220.89366372
63Prolactin signaling pathway_Homo sapiens_hsa049170.89167843
64Retrograde endocannabinoid signaling_Homo sapiens_hsa047230.89096352
65Other types of O-glycan biosynthesis_Homo sapiens_hsa005140.88859587
66RNA transport_Homo sapiens_hsa030130.88623898
67Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006030.88604003
68ECM-receptor interaction_Homo sapiens_hsa045120.88488366
69Butirosin and neomycin biosynthesis_Homo sapiens_hsa005240.87959216
70Progesterone-mediated oocyte maturation_Homo sapiens_hsa049140.87923350
71Pathways in cancer_Homo sapiens_hsa052000.86781821
72Renin secretion_Homo sapiens_hsa049240.84788291
73Melanogenesis_Homo sapiens_hsa049160.83603223
74Fc epsilon RI signaling pathway_Homo sapiens_hsa046640.83550293
75Carbon metabolism_Homo sapiens_hsa012000.81916915
76PPAR signaling pathway_Homo sapiens_hsa033200.81498838
77Arginine biosynthesis_Homo sapiens_hsa002200.81046724
78Base excision repair_Homo sapiens_hsa034100.80807116
79Melanoma_Homo sapiens_hsa052180.80734047
80Transcriptional misregulation in cancer_Homo sapiens_hsa052020.80620499
81GABAergic synapse_Homo sapiens_hsa047270.79745288
82Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa009700.79293452
83Focal adhesion_Homo sapiens_hsa045100.79206588
84Gap junction_Homo sapiens_hsa045400.79077163
85Glioma_Homo sapiens_hsa052140.78997706
86Carbohydrate digestion and absorption_Homo sapiens_hsa049730.78366747
87Small cell lung cancer_Homo sapiens_hsa052220.77855096
88Protein processing in endoplasmic reticulum_Homo sapiens_hsa041410.75915617
89Fatty acid degradation_Homo sapiens_hsa000710.73857130
90Taste transduction_Homo sapiens_hsa047420.73395580
91Morphine addiction_Homo sapiens_hsa050320.72465344
92Inositol phosphate metabolism_Homo sapiens_hsa005620.70606527
93Phosphatidylinositol signaling system_Homo sapiens_hsa040700.70473575
94Lysosome_Homo sapiens_hsa041420.68451075
95Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005330.68013487
96Biosynthesis of amino acids_Homo sapiens_hsa012300.67879471
97GnRH signaling pathway_Homo sapiens_hsa049120.67359975
98Maturity onset diabetes of the young_Homo sapiens_hsa049500.66229804
99Estrogen signaling pathway_Homo sapiens_hsa049150.66065595
100Endometrial cancer_Homo sapiens_hsa052130.64880440
101Lysine degradation_Homo sapiens_hsa003100.63855931
102Insulin secretion_Homo sapiens_hsa049110.63592566
103Dopaminergic synapse_Homo sapiens_hsa047280.63548586
104Ubiquitin mediated proteolysis_Homo sapiens_hsa041200.63493624
105Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa051200.62544734
106ErbB signaling pathway_Homo sapiens_hsa040120.62299055
107Bladder cancer_Homo sapiens_hsa052190.62224120
108Glutathione metabolism_Homo sapiens_hsa004800.61795919
109Endocytosis_Homo sapiens_hsa041440.61283457
110Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa005340.60913491
111alpha-Linolenic acid metabolism_Homo sapiens_hsa005920.58976708
112Dorso-ventral axis formation_Homo sapiens_hsa043200.58857057
113Glutamatergic synapse_Homo sapiens_hsa047240.58242674
114Neurotrophin signaling pathway_Homo sapiens_hsa047220.57118569
115FoxO signaling pathway_Homo sapiens_hsa040680.56846270
116Amyotrophic lateral sclerosis (ALS)_Homo sapiens_hsa050140.56755806
117Fatty acid biosynthesis_Homo sapiens_hsa000610.56654434
118Renal cell carcinoma_Homo sapiens_hsa052110.55526396
119HTLV-I infection_Homo sapiens_hsa051660.55486251
120Glycolysis / Gluconeogenesis_Homo sapiens_hsa000100.54396420
121Ascorbate and aldarate metabolism_Homo sapiens_hsa000530.53132565
122Chronic myeloid leukemia_Homo sapiens_hsa052200.52378372
123Vascular smooth muscle contraction_Homo sapiens_hsa042700.52038701
124cAMP signaling pathway_Homo sapiens_hsa040240.51595905
125Wnt signaling pathway_Homo sapiens_hsa043100.51406841
126Pancreatic secretion_Homo sapiens_hsa049720.51362549
127Ovarian steroidogenesis_Homo sapiens_hsa049130.51311852
128TGF-beta signaling pathway_Homo sapiens_hsa043500.51132964
129Ras signaling pathway_Homo sapiens_hsa040140.50799228
130Long-term potentiation_Homo sapiens_hsa047200.49426731
131AMPK signaling pathway_Homo sapiens_hsa041520.49011212
132Rap1 signaling pathway_Homo sapiens_hsa040150.48753617
133Long-term depression_Homo sapiens_hsa047300.48327540
134Leukocyte transendothelial migration_Homo sapiens_hsa046700.48134165
135Dilated cardiomyopathy_Homo sapiens_hsa054140.47931387
136Regulation of actin cytoskeleton_Homo sapiens_hsa048100.47534769
137MAPK signaling pathway_Homo sapiens_hsa040100.47499021
138Amoebiasis_Homo sapiens_hsa051460.46963455
139Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa045500.46841258
140PI3K-Akt signaling pathway_Homo sapiens_hsa041510.45568861
141Viral carcinogenesis_Homo sapiens_hsa052030.45410968
142Phospholipase D signaling pathway_Homo sapiens_hsa040720.44828287
143Thyroid hormone signaling pathway_Homo sapiens_hsa049190.44552554
144Circadian entrainment_Homo sapiens_hsa047130.44457155
145Prion diseases_Homo sapiens_hsa050200.43653235
146Arrhythmogenic right ventricular cardiomyopathy (ARVC)_Homo sapiens_hsa054120.43447403
147Central carbon metabolism in cancer_Homo sapiens_hsa052300.43024570
148beta-Alanine metabolism_Homo sapiens_hsa004100.42632208
149Insulin signaling pathway_Homo sapiens_hsa049100.40878194
150Cocaine addiction_Homo sapiens_hsa050300.40823958
151Terpenoid backbone biosynthesis_Homo sapiens_hsa009000.40432245
152VEGF signaling pathway_Homo sapiens_hsa043700.39903403
153Cell adhesion molecules (CAMs)_Homo sapiens_hsa045140.39182916

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