HOXB9

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: This gene is a member of the Abd-B homeobox family and encodes a protein with a homeobox DNA-binding domain. It is included in a cluster of homeobox B genes located on chromosome 17. The encoded nuclear protein functions as a sequence-specific transcription factor that is involved in cell proliferation and differentiation. Increased expression of this gene is associated with some cases of leukemia, prostate cancer and lung cancer. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1negative regulation of epidermis development (GO:0045683)6.03000006
2DNA unwinding involved in DNA replication (GO:0006268)5.93766660
3regulation of translational fidelity (GO:0006450)5.87591559
4regulation of apoptotic process involved in morphogenesis (GO:1902337)5.69943402
5somite rostral/caudal axis specification (GO:0032525)5.40275409
6regulation of mammary gland epithelial cell proliferation (GO:0033599)5.39982968
7maintenance of protein location in nucleus (GO:0051457)5.36209301
8pore complex assembly (GO:0046931)5.17081106
9notochord development (GO:0030903)5.12601508
10negative regulation of G2/M transition of mitotic cell cycle (GO:0010972)5.05251868
11regulation of RNA export from nucleus (GO:0046831)4.91108368
12mitotic chromosome condensation (GO:0007076)4.89942499
13DNA replication checkpoint (GO:0000076)4.86315507
14heterochromatin organization (GO:0070828)4.82378108
15regulation of response to osmotic stress (GO:0047484)4.78551076
16C21-steroid hormone biosynthetic process (GO:0006700)4.69719097
17negative regulation of epidermal cell differentiation (GO:0045605)4.52633361
18formation of translation preinitiation complex (GO:0001731)4.49128677
19DNA replication initiation (GO:0006270)4.48889897
20muscle organ morphogenesis (GO:0048644)4.45937985
21protein localization to kinetochore (GO:0034501)4.44715131
22negative regulation of cell cycle G2/M phase transition (GO:1902750)4.44207030
23negative regulation of intracellular estrogen receptor signaling pathway (GO:0033147)4.41136891
24DNA topological change (GO:0006265)4.39131347
25branching involved in mammary gland duct morphogenesis (GO:0060444)4.38969540
26proline biosynthetic process (GO:0006561)4.38346065
27mitotic nuclear envelope disassembly (GO:0007077)4.25544408
28regulation of nuclear cell cycle DNA replication (GO:0033262)4.20029494
29regulation of MHC class I biosynthetic process (GO:0045343)4.15254489
30COPI coating of Golgi vesicle (GO:0048205)4.09778153
31Golgi transport vesicle coating (GO:0048200)4.09778153
32regulation of histone H3-K4 methylation (GO:0051569)4.09718667
33bone trabecula formation (GO:0060346)4.09628656
34regulation of telomere maintenance via telomerase (GO:0032210)4.08675255
35regulation of nucleobase-containing compound transport (GO:0032239)4.06240578
36histone H4-K8 acetylation (GO:0043982)4.05636573
37histone H4-K5 acetylation (GO:0043981)4.05636573
38DNA strand elongation involved in DNA replication (GO:0006271)4.03797359
39membrane disassembly (GO:0030397)4.02086239
40nuclear envelope disassembly (GO:0051081)4.02086239
41cranial nerve morphogenesis (GO:0021602)3.99459097
42mitotic sister chromatid cohesion (GO:0007064)3.98780892
43regulation of mitotic spindle organization (GO:0060236)3.97030728
44negative regulation of mRNA splicing, via spliceosome (GO:0048025)3.95243170
45histone H4-K12 acetylation (GO:0043983)3.93417799
46DNA strand elongation (GO:0022616)3.91402449
47regulation of histone H3-K27 methylation (GO:0061085)3.85699701
48hormone catabolic process (GO:0042447)3.84607337
49folic acid-containing compound biosynthetic process (GO:0009396)3.78906856
50negative regulation of telomerase activity (GO:0051974)3.78027615
51primitive streak formation (GO:0090009)3.73434074
52positive regulation of DNA-dependent DNA replication (GO:2000105)3.73068465
53definitive hemopoiesis (GO:0060216)3.71422318
54rRNA transcription (GO:0009303)3.68676126
55protein-DNA complex disassembly (GO:0032986)3.65515743
56nucleosome disassembly (GO:0006337)3.65515743
57cardiovascular system development (GO:0072358)3.65157174
58mitotic sister chromatid segregation (GO:0000070)3.64529836
59negative regulation of erythrocyte differentiation (GO:0045647)3.62194540
60phenol-containing compound catabolic process (GO:0019336)3.55120191
61chromosome condensation (GO:0030261)3.54109483
62cytidine deamination (GO:0009972)3.52504428
63cytidine metabolic process (GO:0046087)3.52504428
64cytidine catabolic process (GO:0006216)3.52504428
65regulation of transcription involved in G1/S transition of mitotic cell cycle (GO:0000083)3.49960239
66regulation of translational elongation (GO:0006448)3.45788115
67telomere maintenance via semi-conservative replication (GO:0032201)3.45283064
68cell fate commitment involved in formation of primary germ layer (GO:0060795)3.44356820
69regulation of hippo signaling (GO:0035330)3.43486239
70cell proliferation involved in metanephros development (GO:0072203)3.41808389
71quinone metabolic process (GO:1901661)3.40518740
72chromatin assembly (GO:0031497)3.39607220
73regulation of odontogenesis of dentin-containing tooth (GO:0042487)3.35571730
74maintenance of protein localization in organelle (GO:0072595)3.34573784
75DNA packaging (GO:0006323)3.34522707
76thyroid gland development (GO:0030878)3.34218685
77negative regulation of histone methylation (GO:0031061)3.33623122
78protein export from nucleus (GO:0006611)3.32479418
79interferon-gamma production (GO:0032609)3.30192821
80tachykinin receptor signaling pathway (GO:0007217)3.30037490
81phagocytosis, recognition (GO:0006910)3.27195391
82homocysteine metabolic process (GO:0050667)3.24481151
83negative regulation of mRNA processing (GO:0050686)3.22479110
84tRNA aminoacylation for protein translation (GO:0006418)3.21279969
85nuclear envelope organization (GO:0006998)3.21260817
86protoporphyrinogen IX metabolic process (GO:0046501)3.20759592
87regulation of attachment of spindle microtubules to kinetochore (GO:0051988)3.20172369
88pre-miRNA processing (GO:0031054)3.19036623
89rRNA methylation (GO:0031167)3.18704103
90pyrimidine ribonucleoside catabolic process (GO:0046133)3.17784160
91DNA synthesis involved in DNA repair (GO:0000731)3.17664920
92anterior/posterior axis specification (GO:0009948)3.17100437
93DNA conformation change (GO:0071103)3.14737443
94sister chromatid segregation (GO:0000819)3.13694694
95RNA stabilization (GO:0043489)3.13649240
96mRNA stabilization (GO:0048255)3.13649240
97regulation of branching involved in prostate gland morphogenesis (GO:0060687)3.13604727
98intestinal epithelial cell development (GO:0060576)3.13518693
99vitamin A metabolic process (GO:0006776)3.12140771
100negative regulation of fibroblast growth factor receptor signaling pathway (GO:0040037)3.11362023
101amino acid activation (GO:0043038)3.10799242
102tRNA aminoacylation (GO:0043039)3.10799242
103negative regulation of mRNA metabolic process (GO:1903312)3.10320363
104negative regulation of RNA splicing (GO:0033119)3.09546885
105DNA duplex unwinding (GO:0032508)3.08223535
106embryonic skeletal joint morphogenesis (GO:0060272)3.08016811
107viral mRNA export from host cell nucleus (GO:0046784)3.07992783
108face development (GO:0060324)3.07305954
109diterpenoid biosynthetic process (GO:0016102)3.06577831
110paraxial mesoderm development (GO:0048339)3.06091663
111DNA replication-dependent nucleosome organization (GO:0034723)3.02715072
112DNA replication-dependent nucleosome assembly (GO:0006335)3.02715072
113regulation of histone methylation (GO:0031060)3.02602830
114regulation of cilium movement (GO:0003352)2.99174500
115protein localization to chromosome, centromeric region (GO:0071459)2.98843648
116purine nucleobase biosynthetic process (GO:0009113)2.97800385
117maternal placenta development (GO:0001893)2.96247086
118negative regulation of telomere maintenance (GO:0032205)2.96091870
119response to dietary excess (GO:0002021)2.95737786
120cellular modified amino acid catabolic process (GO:0042219)2.93938867
121meiotic chromosome segregation (GO:0045132)2.93180965
122regulation of spindle organization (GO:0090224)2.92532895
123intrinsic apoptotic signaling pathway in response to endoplasmic reticulum stress (GO:0070059)2.92490029
124DNA geometric change (GO:0032392)2.91571261
125telomere maintenance via recombination (GO:0000722)2.91429227
126chromosome segregation (GO:0007059)2.90687083
127nuclear pore complex assembly (GO:0051292)2.90686436
128embryonic skeletal system morphogenesis (GO:0048704)2.89965809
129mRNA transport (GO:0051028)2.89493751
130tetrahydrofolate metabolic process (GO:0046653)2.88974296
131response to epidermal growth factor (GO:0070849)2.87656409
132histone H4-K16 acetylation (GO:0043984)2.87081750
133mitochondrion distribution (GO:0048311)2.86815304
134dosage compensation (GO:0007549)2.85572888
135spliceosomal tri-snRNP complex assembly (GO:0000244)2.85559514
136coenzyme catabolic process (GO:0009109)2.85326272
137regulation of intracellular estrogen receptor signaling pathway (GO:0033146)2.84268010
138mitotic recombination (GO:0006312)2.83998113
139regulation of translation in response to stress (GO:0043555)2.82606557
140nucleobase biosynthetic process (GO:0046112)2.82077459
141nucleoside transmembrane transport (GO:1901642)2.82035471
142retinoic acid receptor signaling pathway (GO:0048384)2.81692868
143cellular protein complex localization (GO:0034629)2.81228562
144retrograde vesicle-mediated transport, Golgi to ER (GO:0006890)2.80414962
145IMP biosynthetic process (GO:0006188)2.79616627
146epoxygenase P450 pathway (GO:0019373)2.78759945
147histone H2B ubiquitination (GO:0033523)2.78079594
148positive regulation of protein deacetylation (GO:0090312)2.77724856
149lymph vessel development (GO:0001945)2.77603662
150transepithelial transport (GO:0070633)2.77499196
151peptidyl-arginine omega-N-methylation (GO:0035247)2.77487064
152regulation of sister chromatid cohesion (GO:0007063)2.76759655
153proximal/distal pattern formation (GO:0009954)2.75640019
154intrinsic apoptotic signaling pathway in response to DNA damage by p53 class mediator (GO:0042771)2.75528293
155intra-S DNA damage checkpoint (GO:0031573)2.75508000
156arachidonic acid secretion (GO:0050482)2.74695565
157icosanoid secretion (GO:0032309)2.74695565
158mesenchymal to epithelial transition involved in metanephros morphogenesis (GO:0003337)2.74524691
159positive regulation of gene expression, epigenetic (GO:0045815)2.74404851
160anterior/posterior axis specification, embryo (GO:0008595)2.72855488
161nuclear pore organization (GO:0006999)2.72013492
162maturation of SSU-rRNA (GO:0030490)2.71602826
163peripheral nervous system neuron development (GO:0048935)2.71346562
164ribosomal small subunit biogenesis (GO:0042274)2.71185380
165negative regulation of cell fate commitment (GO:0010454)2.70340504
166cellular senescence (GO:0090398)2.70301105
167regulation of G0 to G1 transition (GO:0070316)2.69061994
168signal transduction involved in regulation of gene expression (GO:0023019)2.67992200
169rRNA modification (GO:0000154)2.67582364
170regulation of chromatin binding (GO:0035561)2.67406772
171embryonic axis specification (GO:0000578)2.67338046
172regulation of DNA damage checkpoint (GO:2000001)2.65735810
173negative regulation of smoothened signaling pathway (GO:0045879)2.64914142
174maintenance of protein localization in endoplasmic reticulum (GO:0035437)2.64586458
175omega-hydroxylase P450 pathway (GO:0097267)2.64543137
176regulation of gene silencing by RNA (GO:0060966)2.64378018
177regulation of posttranscriptional gene silencing (GO:0060147)2.64378018
178regulation of gene silencing by miRNA (GO:0060964)2.64378018
179regulation of early endosome to late endosome transport (GO:2000641)2.63848240
180regulation of NFAT protein import into nucleus (GO:0051532)2.61193302
181regulation of DNA-dependent DNA replication (GO:0090329)2.61121435
182polyketide metabolic process (GO:0030638)14.6158158
183doxorubicin metabolic process (GO:0044598)14.6158158
184daunorubicin metabolic process (GO:0044597)14.6158158
185aminoglycoside antibiotic metabolic process (GO:0030647)10.3414160

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1BP1_19119308_ChIP-ChIP_Hs578T_Human6.37734908
2* KLF5_18264089_ChIP-ChIP_MESCs_Mouse6.28935105
3* KLF4_18264089_ChIP-ChIP_MESCs_Mouse6.28935105
4* KLF2_18264089_ChIP-ChIP_MESCs_Mouse6.28935105
5TP63_19390658_ChIP-ChIP_HaCaT_Human3.87762065
6NOTCH1_17114293_ChIP-ChIP_T-ALL_Human3.70123938
7EKLF_21900194_ChIP-Seq_ERYTHROCYTE_Mouse3.42865367
8HCFC1_20581084_ChIP-Seq_MESCs_Mouse3.26199457
9EGR1_19374776_ChIP-ChIP_THP-1_Human3.15869880
10SOX2_18358816_ChIP-ChIP_MESCs_Mouse3.10919440
11NACC1_18358816_ChIP-ChIP_MESCs_Mouse2.88620487
12TP63_17297297_ChIP-ChIP_HaCaT_Human2.77852441
13SMAD3_22036565_ChIP-Seq_ESCs_Mouse2.75833047
14XRN2_22483619_ChIP-Seq_HELA_Human2.69096051
15NANOG_18700969_ChIP-ChIP_MESCs_Mouse2.61202263
16POU5F1_18700969_ChIP-ChIP_MESCs_Mouse2.60201235
17TCF3_18692474_ChIP-Seq_MESCs_Mouse2.52490898
18TCF3_18692474_ChIP-Seq_MEFs_Mouse2.51976526
19ZFP281_18358816_ChIP-ChIP_MESCs_Mouse2.45164732
20SMAD1_18555785_ChIP-Seq_MESCs_Mouse2.31866736
21MYC_18358816_ChIP-ChIP_MESCs_Mouse2.16186206
22NANOG_18347094_ChIP-ChIP_MESCs_Mouse2.10246379
23* CDX2_20551321_ChIP-Seq_CACO-2_Human2.09902846
24TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat2.08730709
25MYC_19030024_ChIP-ChIP_MESCs_Mouse2.06336673
26E2F1_21310950_ChIP-Seq_MCF-7_Human2.06170149
27THAP11_20581084_ChIP-Seq_MESCs_Mouse2.04056589
28POU5F1_18555785_ChIP-Seq_MESCs_Mouse2.03881458
29ZIC3_20872845_ChIP-ChIP_MESCs_Mouse2.01564312
30CREB1_23762244_ChIP-Seq_HIPPOCAMPUS_Rat1.99353613
31HIF1A_21447827_ChIP-Seq_MCF-7_Human1.96179909
32E2F7_22180533_ChIP-Seq_HELA_Human1.96151501
33* TTF2_22483619_ChIP-Seq_HELA_Human1.95700867
34PRDM5_23873026_ChIP-Seq_MEFs_Mouse1.90542142
35NANOG_18358816_ChIP-ChIP_MESCs_Mouse1.90301660
36TCF3_18347094_ChIP-ChIP_MESCs_Mouse1.87080631
37CCND1_20090754_ChIP-ChIP_RETINA_Mouse1.81153184
38ZFX_18555785_ChIP-Seq_MESCs_Mouse1.80483725
39SALL4_18804426_ChIP-ChIP_MESCs_Mouse1.80467498
40ZFP281_18757296_ChIP-ChIP_E14_Mouse1.75790076
41KLF4_18358816_ChIP-ChIP_MESCs_Mouse1.75782155
42KDM5A_27292631_Chip-Seq_BREAST_Human1.72972941
43CREB1_15753290_ChIP-ChIP_HEK293T_Human1.71010537
44NELFA_20434984_ChIP-Seq_ESCs_Mouse1.68132910
45* ZFP281_27345836_Chip-Seq_ESCs_Mouse1.66557985
46MYCN_18555785_ChIP-Seq_MESCs_Mouse1.66203117
47NR0B1_18358816_ChIP-ChIP_MESCs_Mouse1.65994068
48TBP_23326641_ChIP-Seq_C3H10T1-2_Mouse1.64265659
49* TP53_20018659_ChIP-ChIP_R1E_Mouse1.58097354
50POU5F1_16153702_ChIP-ChIP_HESCs_Human1.56648947
51FOXM1_23109430_ChIP-Seq_U2OS_Human1.55784556
52CIITA_25753668_ChIP-Seq_RAJI_Human1.54757096
53YY1_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse1.54126494
54E2F4_17652178_ChIP-ChIP_JURKAT_Human1.53050874
55* WT1_20215353_ChIP-ChIP_NEPHRON_PROGENITOR_Mouse1.52942633
56* POU5F1_16518401_ChIP-PET_MESCs_Mouse1.52206197
57ETS1_20019798_ChIP-Seq_JURKAT_Human1.52182279
58ZNF263_19887448_ChIP-Seq_K562_Human1.51857723
59* DCP1A_22483619_ChIP-Seq_HELA_Human1.51360773
60CHD7_19251738_ChIP-ChIP_MESCs_Mouse1.51153888
61VDR_21846776_ChIP-Seq_THP-1_Human1.48477713
62* CREB1_20920259_ChIP-Seq_GC1-SPG_Mouse1.46718575
63IRF1_19129219_ChIP-ChIP_H3396_Human1.46686120
64DACH1_20351289_ChIP-Seq_MDA-MB-231_Human1.45592520
65KDM2B_26808549_Chip-Seq_SIL-ALL_Human1.45526874
66CREM_20920259_ChIP-Seq_GC1-SPG_Mouse1.44644098
67KLF4_18555785_ChIP-Seq_MESCs_Mouse1.44278352
68NANOG_18692474_ChIP-Seq_MESCs_Mouse1.42788201
69PPARG_19300518_ChIP-PET_3T3-L1_Mouse1.42349969
70NANOG_18692474_ChIP-Seq_MEFs_Mouse1.40357116
71POU5F1_18358816_ChIP-ChIP_MESCs_Mouse1.40285723
72* NANOG_16153702_ChIP-ChIP_HESCs_Human1.39252521
73PRDM14_21183938_ChIP-Seq_MESCs_Mouse1.38619440
74TP53_22127205_ChIP-Seq_IMR90_Human1.37948471
75JARID1A_20064375_ChIP-Seq_MESCs_Mouse1.37244581
76FOXM1_25889361_ChIP-Seq_OE33_AND_U2OS_Human1.36376294
77NUCKS1_24931609_ChIP-Seq_HEPATOCYTES_Mouse1.34641918
78* EZH2_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse1.33782272
79* RING1B_27294783_Chip-Seq_NPCs_Mouse1.32212719
80CHD1_26751641_Chip-Seq_LNCaP_Human1.30768842
81SOX2_18555785_ChIP-Seq_MESCs_Mouse1.30234234
82E2F1_17053090_ChIP-ChIP_MCF-7_Human1.30228242
83CNOT3_19339689_ChIP-ChIP_MESCs_Mouse1.28428931
84GATA1_19941826_ChIP-Seq_K562_Human1.28383434
85GABP_19822575_ChIP-Seq_HepG2_Human1.27137458
86ZFP42_18358816_ChIP-ChIP_MESCs_Mouse1.26091300
87STAT3_1855785_ChIP-Seq_MESCs_Mouse1.24334388
88WT1_19549856_ChIP-ChIP_CCG9911_Human1.21360117
89E2F1_18555785_ChIP-Seq_MESCs_Mouse1.21149528
90KLF4_26769127_Chip-Seq_PDAC-Cell_line_Human1.18043200
91POU5F1_18692474_ChIP-Seq_MESCs_Mouse1.15731604
92PPARG_23326641_ChIP-Seq_C3H10T1-2_Mouse1.15141508
93KLF6_26769127_Chip-Seq_PDAC-Cell_line_Human1.13876545
94OCT4_18692474_ChIP-Seq_MEFs_Mouse1.13117253
95RUNX2_24764292_ChIP-Seq_MC3T3_Mouse1.11784592
96* RNF2_27304074_Chip-Seq_NSC_Mouse1.11508350
97NANOG_16518401_ChIP-PET_MESCs_Mouse1.11203503
98P300_27058665_Chip-Seq_ZR-75-30cells_Human1.10753205
99ESR2_21235772_ChIP-Seq_MCF-7_Human1.10621656
100RUNX1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.09052864
101POU5F1_18347094_ChIP-ChIP_MESCs_Mouse1.06214164
102SOX2_18692474_ChIP-Seq_MESCs_Mouse1.05943005
103* BMI1_23680149_ChIP-Seq_NPCS_Mouse1.05601851
104FOXO3_23340844_ChIP-Seq_DLD1_Human1.05320263
105E2F4_21247883_ChIP-Seq_LYMPHOBLASTOID_Human1.04024516
106TRIM28_21343339_ChIP-Seq_HEK293_Human1.03766559
107ESR1_15608294_ChIP-ChIP_MCF-7_Human1.03559416
108* KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human1.03502563
109HOXD13_18407260_ChIP-ChIP_DEVELOPING-LIMBS_Mouse1.03502551
110ESR1_21235772_ChIP-Seq_MCF-7_Human1.03501901
111KLF4_19030024_ChIP-ChIP_MESCs_Mouse1.02699890
112ELK3_25401928_ChIP-Seq_HUVEC_Human1.01835585
113TAL1_20887958_ChIP-Seq_HPC-7_Mouse1.01452964
114KDM2B_26808549_Chip-Seq_HPB-ALL_Human1.00945970
115* KDM2B_26808549_Chip-Seq_SUP-B15_Human1.00708502
116CREB1_26743006_Chip-Seq_LNCaP_Human1.00632030
117NANOG_18555785_ChIP-Seq_MESCs_Mouse1.00301480
118* RACK7_27058665_Chip-Seq_MCF-7_Human0.99852017
119PKCTHETA_26484144_Chip-Seq_BREAST_Human0.99738982
120BCL3_23251550_ChIP-Seq_MUSCLE_Mouse0.99736019
121NANOG_21062744_ChIP-ChIP_HESCs_Human0.99513109
122STAT6_21828071_ChIP-Seq_BEAS2B_Human0.99101859
123TCFAP2C_20176728_ChIP-ChIP_TROPHOBLAST_STEM_CELLS_Mouse0.98260576
124CTCF_27219007_Chip-Seq_ERYTHROID_Human0.97810290
125TCF3_18467660_ChIP-ChIP_MESCs_Mouse0.97466089
126IKZF1_21737484_ChIP-ChIP_HCT116_Human0.96952249
127* ATF3_27146783_Chip-Seq_COLON_Human0.96200131
128CLOCK_20551151_ChIP-Seq_293T_Human0.95043886
129TRP63_18441228_ChIP-ChIP_KERATINOCYTES_Mouse0.94586560
130* NCOR1_26117541_ChIP-Seq_K562_Human0.93925375
131MYBL2_22936984_ChIP-ChIP_MESCs_Mouse0.93873339
132SOX2_18692474_ChIP-Seq_MEFs_Mouse0.93418400
133TBX3_20139965_ChIP-Seq_ESCs_Mouse0.93270628
134* KDM5B_21448134_ChIP-Seq_MESCs_Mouse0.92866702
135CREB1_26743006_Chip-Seq_LNCaP-abl_Human0.92528700
136SRY_22984422_ChIP-ChIP_TESTIS_Rat0.92248149
137SOX2_16153702_ChIP-ChIP_HESCs_Human0.92231032
138TBX3_20139965_ChIP-Seq_MESCs_Mouse0.91769650
139KDM2B_26808549_Chip-Seq_K562_Human0.91010459
140EP300_20729851_ChIP-Seq_FORBRAIN_MIDBRAIN_LIMB_HEART_Mouse0.90897848
141ASXL1_24218140_ChIP-Seq_BMDM_Mouse0.90884465
142* EZH2_18974828_ChIP-Seq_MESCs_Mouse0.90317048
143* RNF2_18974828_ChIP-Seq_MESCs_Mouse0.90317048
144KDM2B_26808549_Chip-Seq_DND41_Human0.90266526
145GATA1_22025678_ChIP-Seq_K562_Human0.89906148
146KDM2B_26808549_Chip-Seq_JURKAT_Human0.89525199
147ZNF652_21678463_ChIP-ChIP_ZR75-1_Human0.88723058
148TFEB_21752829_ChIP-Seq_HELA_Human0.88259562
149* TET1_21451524_ChIP-Seq_MESCs_Mouse0.87415350
150MYC_22102868_ChIP-Seq_BL_Human0.87382564
151SA1_27219007_Chip-Seq_ERYTHROID_Human0.86991196
152ERG_20887958_ChIP-Seq_HPC-7_Mouse0.86753974
153TFAP2A_17053090_ChIP-ChIP_MCF-7_Human0.86442250
154PHC1_16625203_ChIP-ChIP_MESCs_Mouse0.85619271
155FOXM1_26100407_CHIP-SEQ_Hek293_flp-in_Human0.85495024
156P68_20966046_ChIP-Seq_HELA_Human0.85305061
157HOXB4_20404135_ChIP-ChIP_EML_Mouse0.85031046
158* EGR1_20690147_ChIP-Seq_ERYTHROLEUKEMIA_Human0.84585435
159TBX5_21415370_ChIP-Seq_HL-1_Mouse0.83829348
160SIN3A_21632747_ChIP-Seq_MESCs_Mouse0.83532183
161ERG_21242973_ChIP-ChIP_JURKAT_Human0.80688196
162MYC_19079543_ChIP-ChIP_MESCs_Mouse0.80272494
163MYBL1_21750041_ChIP-ChIP_SPERMATOCYTES_Mouse0.80235240
164MYC_18555785_ChIP-Seq_MESCs_Mouse0.78936724
165* STAT3_19079543_ChIP-ChIP_MESCs_Mouse0.77414105
166RARG_19884340_ChIP-ChIP_MEFs_Mouse0.75909397
167LXR_22292898_ChIP-Seq_THP-1_Human0.74849417
168TCF7_22412390_ChIP-Seq_EML_Mouse0.73780441
169SMC4_20622854_ChIP-Seq_HELA_Human0.71561894
170KAP1_27257070_Chip-Seq_ESCs_Mouse0.71056697
171AR_21909140_ChIP-Seq_LNCAP_Human0.70677212
172GATA6_25053715_ChIP-Seq_YYC3_Human0.70221343

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0003693_abnormal_embryo_hatching3.82319003
2MP0003111_abnormal_nucleus_morphology3.76398293
3MP0004264_abnormal_extraembryonic_tissu3.44158099
4MP0006292_abnormal_olfactory_placode3.33356184
5MP0010094_abnormal_chromosome_stability3.31572086
6MP0003705_abnormal_hypodermis_morpholog3.18506076
7MP0003122_maternal_imprinting3.04450233
8MP0003011_delayed_dark_adaptation3.01887086
9MP0010030_abnormal_orbit_morphology2.96517329
10MP0004858_abnormal_nervous_system2.95229744
11MP0000678_abnormal_parathyroid_gland2.88127084
12MP0003890_abnormal_embryonic-extraembry2.76547968
13MP0002254_reproductive_system_inflammat2.76355162
14MP0005257_abnormal_intraocular_pressure2.74314348
15MP0010352_gastrointestinal_tract_polyps2.62892761
16MP0005394_taste/olfaction_phenotype2.57901624
17MP0005499_abnormal_olfactory_system2.57901624
18MP0008058_abnormal_DNA_repair2.35399051
19MP0005076_abnormal_cell_differentiation2.25678828
20MP0005623_abnormal_meninges_morphology2.25376332
21MP0005451_abnormal_body_composition2.24202567
22MP0002932_abnormal_joint_morphology2.21189414
23MP0003121_genomic_imprinting2.18252396
24MP0001730_embryonic_growth_arrest2.18237369
25MP0003938_abnormal_ear_development2.04473455
26MP0008007_abnormal_cellular_replicative2.02349988
27MP0010234_abnormal_vibrissa_follicle2.01032656
28MP0004147_increased_porphyrin_level1.95930059
29MP0000762_abnormal_tongue_morphology1.92770045
30MP0004957_abnormal_blastocyst_morpholog1.89043871
31MP0010307_abnormal_tumor_latency1.87159134
32MP0003123_paternal_imprinting1.86787301
33MP0005075_abnormal_melanosome_morpholog1.84120766
34MP0004043_abnormal_pH_regulation1.83025125
35MP0000049_abnormal_middle_ear1.79327055
36MP0008995_early_reproductive_senescence1.78836907
37MP0009250_abnormal_appendicular_skeleto1.77939814
38MP0001293_anophthalmia1.77103039
39MP0001346_abnormal_lacrimal_gland1.71025999
40MP0003878_abnormal_ear_physiology1.70385211
41MP0005377_hearing/vestibular/ear_phenot1.70385211
42MP0002332_abnormal_exercise_endurance1.68816805
43MP0000681_abnormal_thyroid_gland1.67442789
44MP0003942_abnormal_urinary_system1.63824353
45MP0002233_abnormal_nose_morphology1.63259195
46MP0002249_abnormal_larynx_morphology1.63192688
47MP0004233_abnormal_muscle_weight1.61614124
48MP0001697_abnormal_embryo_size1.60645224
49MP0008057_abnormal_DNA_replication1.56784227
50MP0004185_abnormal_adipocyte_glucose1.56724301
51MP0008961_abnormal_basal_metabolism1.56133175
52MP0002277_abnormal_respiratory_mucosa1.55607733
53MP0002080_prenatal_lethality1.53375074
54MP0003755_abnormal_palate_morphology1.52886594
55MP0005508_abnormal_skeleton_morphology1.51755389
56MP0000534_abnormal_ureter_morphology1.51267052
57MP0003937_abnormal_limbs/digits/tail_de1.48939783
58* MP0002114_abnormal_axial_skeleton1.48566781
59MP0001672_abnormal_embryogenesis/_devel1.48324904
60MP0005380_embryogenesis_phenotype1.48324904
61MP0002092_abnormal_eye_morphology1.47364154
62MP0002009_preneoplasia1.46115018
63MP0002396_abnormal_hematopoietic_system1.43403758
64MP0002653_abnormal_ependyma_morphology1.40038544
65MP0003935_abnormal_craniofacial_develop1.39615440
66MP0002088_abnormal_embryonic_growth/wei1.37026419
67MP0000313_abnormal_cell_death1.36464508
68MP0005248_abnormal_Harderian_gland1.35929281
69MP0003984_embryonic_growth_retardation1.35630958
70MP0009697_abnormal_copulation1.35615151
71MP0003786_premature_aging1.34120676
72MP0000428_abnormal_craniofacial_morphol1.33950402
73MP0001849_ear_inflammation1.33625955
74MP0005187_abnormal_penis_morphology1.32660531
75MP0003385_abnormal_body_wall1.32115166
76MP0001348_abnormal_lacrimal_gland1.31522951
77MP0000432_abnormal_head_morphology1.31185800
78MP0004782_abnormal_surfactant_physiolog1.30341483
79MP0002085_abnormal_embryonic_tissue1.30230688
80MP0002127_abnormal_cardiovascular_syste1.26488012
81MP0004272_abnormal_basement_membrane1.23358175
82MP0003315_abnormal_perineum_morphology1.18929124
83MP0002116_abnormal_craniofacial_bone1.18891477
84MP0002132_abnormal_respiratory_system1.18276832
85MP0001188_hyperpigmentation1.16531300
86MP0009672_abnormal_birth_weight1.15824284
87MP0006035_abnormal_mitochondrial_morpho1.12608010
88MP0005409_darkened_coat_color1.10330933
89MP0010368_abnormal_lymphatic_system1.09769633
90MP0002084_abnormal_developmental_patter1.07605670
91MP0008789_abnormal_olfactory_epithelium1.07243316
92MP0000350_abnormal_cell_proliferation1.06150210
93MP0003283_abnormal_digestive_organ1.05767244
94MP0002086_abnormal_extraembryonic_tissu1.05047718
95MP0008004_abnormal_stomach_pH1.03880368
96MP0003119_abnormal_digestive_system1.03382238
97MP0002111_abnormal_tail_morphology1.03276398
98MP0003941_abnormal_skin_development1.02788573
99MP0002234_abnormal_pharynx_morphology1.01913473
100MP0009278_abnormal_bone_marrow1.01751780
101MP0002925_abnormal_cardiovascular_devel0.98643953
102MP0003656_abnormal_erythrocyte_physiolo0.98391834
103MP0005023_abnormal_wound_healing0.97792060
104MP0000537_abnormal_urethra_morphology0.97576315
105MP0005367_renal/urinary_system_phenotyp0.95512706
106MP0000516_abnormal_urinary_system0.95512706
107MP0002109_abnormal_limb_morphology0.95009752
108MP0005666_abnormal_adipose_tissue0.94597903
109MP0004808_abnormal_hematopoietic_stem0.94411961
110MP0003861_abnormal_nervous_system0.93942467
111MP0000566_synostosis0.93446712
112MP0004197_abnormal_fetal_growth/weight/0.93345885
113MP0002098_abnormal_vibrissa_morphology0.93059377
114MP0005503_abnormal_tendon_morphology0.92467973
115MP0000163_abnormal_cartilage_morphology0.92450955
116MP0002751_abnormal_autonomic_nervous0.92347423
117MP0000733_abnormal_muscle_development0.90359213
118MP0009053_abnormal_anal_canal0.90155129
119MP0003566_abnormal_cell_adhesion0.88593781
120MP0003115_abnormal_respiratory_system0.88481115
121MP0001270_distended_abdomen0.87062971
122MP0002210_abnormal_sex_determination0.86385554
123MP0001727_abnormal_embryo_implantation0.84720856
124MP0003183_abnormal_peptide_metabolism0.83582576
125MP0002938_white_spotting0.82255524
126MP0002139_abnormal_hepatobiliary_system0.82009799
127MP0000467_abnormal_esophagus_morphology0.80837924
128MP0001286_abnormal_eye_development0.79854789
129MP0000477_abnormal_intestine_morphology0.79201998
130MP0001661_extended_life_span0.79121337
131MP0002081_perinatal_lethality0.77626089
132MP0008770_decreased_survivor_rate0.77584799
133MP0000490_abnormal_crypts_of0.77578934
134MP0008438_abnormal_cutaneous_collagen0.77513434
135MP0008932_abnormal_embryonic_tissue0.76724077
136MP0003959_abnormal_lean_body0.75496918
137MP0001873_stomach_inflammation0.74096592
138MP0002697_abnormal_eye_size0.73382290
139MP0003077_abnormal_cell_cycle0.73161239
140MP0005391_vision/eye_phenotype0.72913025
141MP0010630_abnormal_cardiac_muscle0.72502307
142MP0005397_hematopoietic_system_phenotyp0.72247518
143MP0001545_abnormal_hematopoietic_system0.72247518
144MP0009703_decreased_birth_body0.71248532
145MP0005501_abnormal_skin_physiology0.71235812
146MP0002877_abnormal_melanocyte_morpholog0.70554133
147MP0009931_abnormal_skin_appearance0.70473369
148MP0003045_fibrosis0.69342065
149MP0003221_abnormal_cardiomyocyte_apopto0.69317401
150MP0003936_abnormal_reproductive_system0.67994533
151MP0001145_abnormal_male_reproductive0.67616594
152MP0001929_abnormal_gametogenesis0.67584269

Predicted human phenotypes

RankGene SetZ-score
1Bilateral microphthalmos (HP:0007633)6.41305567
2Truncus arteriosus (HP:0001660)5.57302159
3Hepatoblastoma (HP:0002884)5.10933098
4Cholecystitis (HP:0001082)4.81611754
5Abnormal gallbladder physiology (HP:0012438)4.81611754
6Hyperthyroidism (HP:0000836)4.45577422
7Hypochromic microcytic anemia (HP:0004840)4.16792988
8Rib fusion (HP:0000902)3.99242414
9Multiple enchondromatosis (HP:0005701)3.86765057
10Ankyloglossia (HP:0010296)3.82548708
11Cortical dysplasia (HP:0002539)3.67789767
12Septate vagina (HP:0001153)3.67657414
13Bowel incontinence (HP:0002607)3.67489925
14Abnormality of the lower motor neuron (HP:0002366)3.63771528
15Abnormal large intestine physiology (HP:0012700)3.56944079
16Partial duplication of the phalanx of hand (HP:0009999)3.54994494
17Birth length less than 3rd percentile (HP:0003561)3.54971254
18Partial duplication of thumb phalanx (HP:0009944)3.45001708
19Reticulocytosis (HP:0001923)3.44454215
20Ependymoma (HP:0002888)3.38966595
21Nephroblastoma (Wilms tumor) (HP:0002667)3.34003953
22Shawl scrotum (HP:0000049)3.28724154
23Increased nuchal translucency (HP:0010880)3.21831221
24Neoplasm of striated muscle (HP:0009728)3.16203725
25Abnormality of reticulocytes (HP:0004312)3.15864395
26Embryonal renal neoplasm (HP:0011794)3.13918541
27Fused cervical vertebrae (HP:0002949)3.12911022
28Hypertensive crisis (HP:0100735)3.07091321
29Dysmetric saccades (HP:0000641)3.03868088
30Chromosomal breakage induced by crosslinking agents (HP:0003221)2.93401724
31Seborrheic dermatitis (HP:0001051)2.93316261
32Renal duplication (HP:0000075)2.93130202
33Atelectasis (HP:0100750)2.92738481
34Rhabdomyosarcoma (HP:0002859)2.90775875
35Insomnia (HP:0100785)2.88347285
36Polycythemia (HP:0001901)2.82186578
37Short humerus (HP:0005792)2.80808264
38Bifid tongue (HP:0010297)2.79649249
39Ileus (HP:0002595)2.76543778
40Abnormality of the phalanges of the hallux (HP:0010057)2.76255098
41Abnormality of the fingertips (HP:0001211)2.73671074
42Astrocytoma (HP:0009592)2.71772571
43Abnormality of the astrocytes (HP:0100707)2.71772571
44Aplasia/hypoplasia of the humerus (HP:0006507)2.70865189
45Rectal fistula (HP:0100590)2.69340557
46Rectovaginal fistula (HP:0000143)2.69340557
47Abnormality of oral frenula (HP:0000190)2.67231761
48Hyperacusis (HP:0010780)2.65367865
49Abnormality of homocysteine metabolism (HP:0010919)2.65026241
50Homocystinuria (HP:0002156)2.65026241
51Trismus (HP:0000211)2.63477546
52Disproportionate tall stature (HP:0001519)2.62552258
53Hypoparathyroidism (HP:0000829)2.61384767
54Nasolacrimal duct obstruction (HP:0000579)2.60518734
55Obsessive-compulsive behavior (HP:0000722)2.59795612
56Abnormal lung lobation (HP:0002101)2.55975405
57Testicular atrophy (HP:0000029)2.55942998
58Reticulocytopenia (HP:0001896)2.55508108
59Abnormally folded helix (HP:0008544)2.55368650
60Renal salt wasting (HP:0000127)2.54630227
61Patellar dislocation (HP:0002999)2.54542416
62Short middle phalanx of the 5th finger (HP:0004220)2.54458892
63Abnormality of the tricuspid valve (HP:0001702)2.52801340
64Abnormality of the distal phalanx of the thumb (HP:0009617)2.52052102
65Acute myeloid leukemia (HP:0004808)2.51494513
66Anomalous pulmonary venous return (HP:0010772)2.44055251
67Hypoplasia of the fovea (HP:0007750)2.43388074
68Aplasia/Hypoplasia of the fovea (HP:0008060)2.43388074
69Abnormality of cochlea (HP:0000375)2.42800748
70Cholelithiasis (HP:0001081)2.41642484
71Cheilitis (HP:0100825)2.38858263
72Preauricular pit (HP:0004467)2.38069892
73Periauricular skin pits (HP:0100277)2.38069892
74Urethral obstruction (HP:0000796)2.38046704
75Increased connective tissue (HP:0009025)2.37683191
76Chromsome breakage (HP:0040012)2.37286108
77Hyperaldosteronism (HP:0000859)2.36164932
78Ulnar bowing (HP:0003031)2.35711912
79Intestinal fistula (HP:0100819)2.35392262
80Preauricular skin tag (HP:0000384)2.33759650
81Hand muscle atrophy (HP:0009130)2.31906575
82Abnormality of the gallbladder (HP:0005264)2.31628391
83Unilateral renal agenesis (HP:0000122)2.30693895
84Flat cornea (HP:0007720)2.29497088
85High anterior hairline (HP:0009890)2.29474228
86Abnormality of the salivary glands (HP:0010286)2.28800724
87Vaginal fistula (HP:0004320)2.27412113
88Attention deficit hyperactivity disorder (HP:0007018)2.25718627
89Neoplasm of the heart (HP:0100544)2.25089371
90Proximal placement of thumb (HP:0009623)2.24330594
91Short 5th finger (HP:0009237)2.23821686
92Abnormal number of incisors (HP:0011064)2.23206601
93Abnormality of the aortic arch (HP:0012303)2.22870779
94Abnormality of the pulmonary veins (HP:0011718)2.22649325
95Large earlobe (HP:0009748)2.21831301
96Abnormality of glycolysis (HP:0004366)2.20096999
97Abnormal cartilage morphology (HP:0002763)2.19333003
98Protrusio acetabuli (HP:0003179)2.19277432
99Generalized hypotonia (HP:0001290)2.15645164
100Sandal gap (HP:0001852)2.15117209
101Abnormality of the musculature of the hand (HP:0001421)2.12366888
102Overlapping toe (HP:0001845)2.12355590
103Macroorchidism (HP:0000053)2.11637915
104Abnormality of the calcaneus (HP:0008364)2.10922552
105Recurrent corneal erosions (HP:0000495)2.09640347
106Cheekbone underdevelopment (HP:0010669)2.09598545
107Skin tags (HP:0010609)2.09261908
108Duplication of thumb phalanx (HP:0009942)2.08705623
109Breast hypoplasia (HP:0003187)2.07643435
110Lymphangioma (HP:0100764)2.07352682
111Nonimmune hydrops fetalis (HP:0001790)2.07109994
112Deviation of the thumb (HP:0009603)2.06764738
113Hypoplastic scapulae (HP:0000882)2.04923346
114Aplasia/Hypoplasia of the scapulae (HP:0006713)2.04923346
115Malignant neoplasm of the central nervous system (HP:0100836)2.04327092
116Abnormality of the lacrimal duct (HP:0011481)2.04040466
117Abnormal gallbladder morphology (HP:0012437)2.03828062
118Aplasia/Hypoplasia of the 5th finger (HP:0006262)2.02214056
119Abnormal ventriculo-arterial connection (HP:0011563)2.00555833
120Transposition of the great arteries (HP:0001669)2.00555833
121Abnormal connection of the cardiac segments (HP:0011545)2.00555833
122Preaxial foot polydactyly (HP:0001841)2.00132899
123Overfolded helix (HP:0000396)1.99735028
124Abnormality of the fetal cardiovascular system (HP:0010948)1.98522907
125Abnormal umbilical cord blood vessels (HP:0011403)1.98522907
126Single umbilical artery (HP:0001195)1.98522907
127Glioma (HP:0009733)1.94699461
128Upper limb amyotrophy (HP:0009129)1.93972480
129Distal upper limb amyotrophy (HP:0007149)1.93972480
130Abnormality of the nasolacrimal system (HP:0000614)1.93950311
131Mildly elevated creatine phosphokinase (HP:0008180)1.93910382
132Aplasia/Hypoplasia of the earlobes (HP:0009906)1.93184687
133Peritonitis (HP:0002586)1.93042030
134Amyotrophic lateral sclerosis (HP:0007354)1.92936183
135Meckel diverticulum (HP:0002245)1.92798301
136Orthostatic hypotension (HP:0001278)1.92567493
137Neonatal short-limb short stature (HP:0008921)1.91316961
138Ragged-red muscle fibers (HP:0003200)1.90391289
139Pendular nystagmus (HP:0012043)1.90373517
140Upper limb muscle weakness (HP:0003484)1.90072314
141Supernumerary nipples (HP:0002558)1.89861296
142Horizontal nystagmus (HP:0000666)1.88969267
143Congenital malformation of the right heart (HP:0011723)1.88582666
144Double outlet right ventricle (HP:0001719)1.88582666
145Hammertoe (HP:0001765)1.85916059
146Atresia of the external auditory canal (HP:0000413)1.85781388
147Premature rupture of membranes (HP:0001788)1.85035181
14811 pairs of ribs (HP:0000878)1.84270365
149Increased circulating renin level (HP:0000848)1.84215556
150Reduced antithrombin III activity (HP:0001976)1.83940295
151Hyperactive renin-angiotensin system (HP:0000841)1.83746532
152Abnormality of the pubic bones (HP:0003172)1.82873498
153Abnormality of renin-angiotensin system (HP:0000847)1.82856524
154Self-mutilation (HP:0000742)1.81916908
155Prominent occiput (HP:0000269)1.79982253
156Vertebral fusion (HP:0002948)1.79915244
157Microretrognathia (HP:0000308)1.79254668
158Aplasia/Hypoplasia of the sacrum (HP:0008517)1.79046631
159Long eyelashes (HP:0000527)1.78952779
160Elfin facies (HP:0004428)1.78856936
161Abnormality of the ileum (HP:0001549)1.78596060
162Skin pits (HP:0100276)1.77278135
163Morphological abnormality of the inner ear (HP:0011390)1.77044949
164Broad distal phalanx of finger (HP:0009836)1.75863460
165Ectopic kidney (HP:0000086)1.75835556
166Tinnitus (HP:0000360)1.75666739
167Supernumerary ribs (HP:0005815)1.75164434
168Calcaneovalgus deformity (HP:0001848)1.74157603
169Cafe-au-lait spot (HP:0000957)1.73610867
170Congenital diaphragmatic hernia (HP:0000776)1.73155563
171Abnormality of the fovea (HP:0000493)1.72458773
172Overriding aorta (HP:0002623)1.72274113
173Mesomelia (HP:0003027)1.72246823
174Pheochromocytoma (HP:0002666)1.71974489
175Hypopigmentation of the fundus (HP:0007894)1.71513111
176Optic nerve coloboma (HP:0000588)1.71196985
177Aplastic anemia (HP:0001915)1.70441410
178Increased serum pyruvate (HP:0003542)1.70161033
179Supernumerary spleens (HP:0009799)1.69867823
180Long foot (HP:0001833)1.69587942
181Large hands (HP:0001176)1.69387311
182Aplasia/Hypoplasia of the uvula (HP:0010293)1.68819513
183Abnormality of chromosome segregation (HP:0002916)1.67517303
184Pointed chin (HP:0000307)1.67309775
185Deep palmar crease (HP:0006191)1.67251247
186Progressive muscle weakness (HP:0003323)1.66757999
187Myopathic facies (HP:0002058)1.65828107
188Horseshoe kidney (HP:0000085)1.64999031
189Vesicoureteral reflux (HP:0000076)1.64849131

Predicted kinase interactions (KEA)

RankGene SetZ-score
1CDK127.69224492
2EEF2K5.33867938
3ERN14.90535551
4GRK54.46157328
5GRK63.34608759
6ICK3.05704755
7IRAK33.01097112
8ADRBK22.81878554
9GRK12.76240072
10TGFBR22.72085861
11AKT32.71530869
12EIF2AK12.70702298
13KSR22.68603475
14WNK12.45878590
15TTK2.44022444
16CSF1R2.26946303
17PAK42.26598299
18SMG12.18422938
19EPHA22.15143218
20STK102.13180005
21TYRO32.02297888
22CLK11.95904496
23MST1R1.94845041
24MAPK71.94308356
25BUB11.93624924
26LATS21.92931517
27SIK31.87265279
28MATK1.86715746
29GRK71.84365624
30MAP3K21.81328699
31SRPK11.78321673
32LATS11.77506417
33MOS1.74384103
34CDK71.64908057
35SIK11.64830444
36RIPK41.62779977
37WEE11.54905366
38KSR11.50921279
39PRKG21.39415422
40MARK21.38062000
41NTRK31.32572522
42RAF11.32043391
43ATR1.28591079
44CAMK41.28585688
45NTRK11.26826965
46PLK41.26162048
47SCYL21.25102336
48SIK21.25100264
49STK38L1.18323429
50NME21.10697896
51ADRBK11.09247937
52CAMK1G1.08847681
53BRAF1.07672684
54BRSK11.06054960
55NME11.05412446
56FGFR31.03524967
57CAMK1D1.01828994
58MKNK11.00143568
59MAP3K100.96648605
60PDGFRA0.94717769
61BMPR20.94292708
62PTK20.91904354
63CHEK20.91232872
64TSSK60.87369920
65BRD40.86330584
66MAP2K40.81492957
67ALK0.81182453
68PBK0.81174529
69PLK10.79589610
70EPHB20.76888153
71DDR20.76832675
72CDK40.76510864
73PNCK0.76127723
74HIPK20.76030560
75STK40.74860847
76RPS6KA40.71070515
77BRSK20.70787110
78AKT20.69742610
79PTK60.69412919
80MTOR0.68878437
81WNK30.68782689
82MKNK20.68773001
83STK380.68529605
84IRAK20.68187244
85PKN20.67358918
86PASK0.67089176
87TAOK20.65712788
88MAP3K70.64119272
89BMX0.62048780
90ILK0.60893122
91ERBB20.60308102
92MAP2K60.58724663
93CHEK10.58541623
94CCNB10.55808201
95PAK20.55071565
96RET0.54860198
97CDK11A0.50791175
98MAP3K10.50390371
99CDK80.49642152
100MST40.49472075
101PAK30.48424106
102RIPK10.46807330
103CDK150.46339814
104DYRK30.46259704
105RPS6KB20.46229947
106MAPK120.45102506
107PRKAA10.43376548
108PRKCI0.42862920
109LRRK20.42728346
110PLK30.42720341
111PDK20.42514589
112CDK180.42490576
113STK30.42041045
114FGFR40.41247309
115MAPKAPK50.40367018
116IGF1R0.39191231
117EIF2AK20.37813754
118TRIB30.37475771
119MAP2K20.37052301
120FER0.36374389
121PRKDC0.35917801
122CSK0.35070749
123WNK40.34827323
124MAPK110.34797902
125PAK10.34599445
126INSR0.34126597
127NEK20.33591515
128PHKG20.32189535
129CSNK1E0.31489601
130CDK20.30720946
131MAPKAPK30.25539002
132TTN0.25188700
133MET0.24979888
134OXSR10.24355758
135PRKD20.22978823
136AURKA0.22891586
137MAPK10.21789392
138AURKB0.20991500
139TNK20.19781223
140ATM0.18894962
141SRC0.18853645
142MARK30.18556386
143MAP3K80.18154203
144PRKCD0.17715550
145PRPF4B0.16708323
146CDK10.16079625
147MAPK140.15963823
148MAPK100.15524080
149LIMK10.15050886
150TESK20.14603339
151NEK10.14193514
152GSK3B0.13840419
153TAOK10.13484522
154LMTK20.12710655
155AKT10.12692871
156CDC70.11656578

Predicted pathways (KEGG)

RankGene SetZ-score
1Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006036.63992659
2Vitamin B6 metabolism_Homo sapiens_hsa007504.58715689
3DNA replication_Homo sapiens_hsa030303.63128481
4Butirosin and neomycin biosynthesis_Homo sapiens_hsa005243.36177866
5Fructose and mannose metabolism_Homo sapiens_hsa000512.90674081
6Mismatch repair_Homo sapiens_hsa034302.73394287
7Arachidonic acid metabolism_Homo sapiens_hsa005902.56489927
8Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030082.44796219
9Citrate cycle (TCA cycle)_Homo sapiens_hsa000202.28524477
10Basal cell carcinoma_Homo sapiens_hsa052172.08309591
11alpha-Linolenic acid metabolism_Homo sapiens_hsa005922.02718360
12Ovarian steroidogenesis_Homo sapiens_hsa049131.94354776
13Biosynthesis of amino acids_Homo sapiens_hsa012301.93954236
14Hedgehog signaling pathway_Homo sapiens_hsa043401.88310127
15Galactose metabolism_Homo sapiens_hsa000521.86428200
16Homologous recombination_Homo sapiens_hsa034401.83413802
17Base excision repair_Homo sapiens_hsa034101.83033885
18Hippo signaling pathway_Homo sapiens_hsa043901.82090437
19Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa045501.74264416
20Nucleotide excision repair_Homo sapiens_hsa034201.72459699
21Linoleic acid metabolism_Homo sapiens_hsa005911.69469178
22Pentose and glucuronate interconversions_Homo sapiens_hsa000401.65194373
232-Oxocarboxylic acid metabolism_Homo sapiens_hsa012101.60998053
24Thyroid cancer_Homo sapiens_hsa052161.60032864
25Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009801.50478780
26Bladder cancer_Homo sapiens_hsa052191.48934141
27mTOR signaling pathway_Homo sapiens_hsa041501.45593673
28MicroRNAs in cancer_Homo sapiens_hsa052061.44687042
29Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa005341.40899718
30Regulation of actin cytoskeleton_Homo sapiens_hsa048101.39553535
31Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa005201.39306062
32Carbon metabolism_Homo sapiens_hsa012001.37059432
33Ribosome_Homo sapiens_hsa030101.33680855
34Adherens junction_Homo sapiens_hsa045201.33604430
35Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006041.33180806
36Steroid hormone biosynthesis_Homo sapiens_hsa001401.33017193
37Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa009701.32087018
38Proteoglycans in cancer_Homo sapiens_hsa052051.29795058
39Tight junction_Homo sapiens_hsa045301.22443979
40Non-homologous end-joining_Homo sapiens_hsa034501.20702899
41Pathways in cancer_Homo sapiens_hsa052001.20591297
42Wnt signaling pathway_Homo sapiens_hsa043101.19369053
43Pyruvate metabolism_Homo sapiens_hsa006201.19277978
44RNA transport_Homo sapiens_hsa030131.18469058
45Transcriptional misregulation in cancer_Homo sapiens_hsa052021.17236119
46Sulfur relay system_Homo sapiens_hsa041221.17198403
47Rap1 signaling pathway_Homo sapiens_hsa040151.17139753
48Arrhythmogenic right ventricular cardiomyopathy (ARVC)_Homo sapiens_hsa054121.16341872
49Cysteine and methionine metabolism_Homo sapiens_hsa002701.15936911
50Pentose phosphate pathway_Homo sapiens_hsa000301.14645492
51mRNA surveillance pathway_Homo sapiens_hsa030151.13320905
52Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa049611.10181474
53Progesterone-mediated oocyte maturation_Homo sapiens_hsa049141.09120778
54Renal cell carcinoma_Homo sapiens_hsa052111.07549739
55Insulin signaling pathway_Homo sapiens_hsa049101.07134964
56Cell cycle_Homo sapiens_hsa041101.06822831
57Protein digestion and absorption_Homo sapiens_hsa049741.06709633
58ECM-receptor interaction_Homo sapiens_hsa045121.06457153
59Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008601.02745102
60Focal adhesion_Homo sapiens_hsa045101.02713416
61Phospholipase D signaling pathway_Homo sapiens_hsa040721.02251252
62Leukocyte transendothelial migration_Homo sapiens_hsa046700.99008910
63Arginine biosynthesis_Homo sapiens_hsa002200.98832244
64Notch signaling pathway_Homo sapiens_hsa043300.97151881
65PI3K-Akt signaling pathway_Homo sapiens_hsa041510.93193774
66Type II diabetes mellitus_Homo sapiens_hsa049300.92320918
67Prion diseases_Homo sapiens_hsa050200.90921542
68Pyrimidine metabolism_Homo sapiens_hsa002400.90475791
69Glioma_Homo sapiens_hsa052140.89788320
70Maturity onset diabetes of the young_Homo sapiens_hsa049500.89588511
71Choline metabolism in cancer_Homo sapiens_hsa052310.89221139
72Longevity regulating pathway - multiple species_Homo sapiens_hsa042130.87900210
73Other glycan degradation_Homo sapiens_hsa005110.87885491
74Melanoma_Homo sapiens_hsa052180.87815339
75Mineral absorption_Homo sapiens_hsa049780.87754783
76Basal transcription factors_Homo sapiens_hsa030220.87371690
77TGF-beta signaling pathway_Homo sapiens_hsa043500.82751470
78Axon guidance_Homo sapiens_hsa043600.82058512
79Oocyte meiosis_Homo sapiens_hsa041140.81730801
80p53 signaling pathway_Homo sapiens_hsa041150.81372905
81Small cell lung cancer_Homo sapiens_hsa052220.79028180
82Viral carcinogenesis_Homo sapiens_hsa052030.77983563
83Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006300.74782746
84Ubiquitin mediated proteolysis_Homo sapiens_hsa041200.74685747
85Fanconi anemia pathway_Homo sapiens_hsa034600.74063105
86Glycosaminoglycan degradation_Homo sapiens_hsa005310.73692834
87Chemical carcinogenesis_Homo sapiens_hsa052040.73161021
88Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002500.72419712
89Longevity regulating pathway - mammal_Homo sapiens_hsa042110.71500925
90Pancreatic cancer_Homo sapiens_hsa052120.68646135
91Ras signaling pathway_Homo sapiens_hsa040140.68504782
92Central carbon metabolism in cancer_Homo sapiens_hsa052300.68273598
93Protein processing in endoplasmic reticulum_Homo sapiens_hsa041410.65685556
94Inositol phosphate metabolism_Homo sapiens_hsa005620.65397006
95Thyroid hormone signaling pathway_Homo sapiens_hsa049190.63496583
96Neurotrophin signaling pathway_Homo sapiens_hsa047220.63274436
97One carbon pool by folate_Homo sapiens_hsa006700.61972123
98HIF-1 signaling pathway_Homo sapiens_hsa040660.61779156
99Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004000.61091998
100Non-small cell lung cancer_Homo sapiens_hsa052230.60708079
101Cell adhesion molecules (CAMs)_Homo sapiens_hsa045140.59070868
102HTLV-I infection_Homo sapiens_hsa051660.58882877
103Prostate cancer_Homo sapiens_hsa052150.58190387
104Hypertrophic cardiomyopathy (HCM)_Homo sapiens_hsa054100.57632305
105Pathogenic Escherichia coli infection_Homo sapiens_hsa051300.56603788
106Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa047500.55687407
107Ether lipid metabolism_Homo sapiens_hsa005650.55121987
108Selenocompound metabolism_Homo sapiens_hsa004500.54639727
109Bacterial invasion of epithelial cells_Homo sapiens_hsa051000.54196000
110Purine metabolism_Homo sapiens_hsa002300.54098892
111Prolactin signaling pathway_Homo sapiens_hsa049170.50909400
112Vascular smooth muscle contraction_Homo sapiens_hsa042700.50098034
113Fc gamma R-mediated phagocytosis_Homo sapiens_hsa046660.50058904
114N-Glycan biosynthesis_Homo sapiens_hsa005100.48605923
115RIG-I-like receptor signaling pathway_Homo sapiens_hsa046220.47662251
116Endometrial cancer_Homo sapiens_hsa052130.47590368
117Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa049600.46908765
118Acute myeloid leukemia_Homo sapiens_hsa052210.45995240
119Glycolysis / Gluconeogenesis_Homo sapiens_hsa000100.44912105
120Other types of O-glycan biosynthesis_Homo sapiens_hsa005140.44839165
121Arginine and proline metabolism_Homo sapiens_hsa003300.44669544
122RNA polymerase_Homo sapiens_hsa030200.44294441
123Lysine degradation_Homo sapiens_hsa003100.44249469
124Fc epsilon RI signaling pathway_Homo sapiens_hsa046640.43999799
125Colorectal cancer_Homo sapiens_hsa052100.43598465
126Dilated cardiomyopathy_Homo sapiens_hsa054140.43443124
127Serotonergic synapse_Homo sapiens_hsa047260.43335282
128Epstein-Barr virus infection_Homo sapiens_hsa051690.43231130
129RNA degradation_Homo sapiens_hsa030180.42691202
130Fatty acid biosynthesis_Homo sapiens_hsa000610.42442385
131Hepatitis B_Homo sapiens_hsa051610.41698085
132Spliceosome_Homo sapiens_hsa030400.40996812
133VEGF signaling pathway_Homo sapiens_hsa043700.40609584
134Apoptosis_Homo sapiens_hsa042100.39873022
135ErbB signaling pathway_Homo sapiens_hsa040120.39592106
136AMPK signaling pathway_Homo sapiens_hsa041520.37685609
137Taste transduction_Homo sapiens_hsa047420.36571864
138Long-term potentiation_Homo sapiens_hsa047200.34618548
139AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa049330.34084614
140Carbohydrate digestion and absorption_Homo sapiens_hsa049730.33743449
141Steroid biosynthesis_Homo sapiens_hsa001000.33582363
142Amyotrophic lateral sclerosis (ALS)_Homo sapiens_hsa050140.33263174
143B cell receptor signaling pathway_Homo sapiens_hsa046620.31569750
144African trypanosomiasis_Homo sapiens_hsa051430.31315684
145Estrogen signaling pathway_Homo sapiens_hsa049150.31022451
146Sphingolipid signaling pathway_Homo sapiens_hsa040710.29733756
147Chronic myeloid leukemia_Homo sapiens_hsa052200.29638808
148Cyanoamino acid metabolism_Homo sapiens_hsa004600.28912638
149Chagas disease (American trypanosomiasis)_Homo sapiens_hsa051420.28561178
150Sulfur metabolism_Homo sapiens_hsa009200.28244470
151Adipocytokine signaling pathway_Homo sapiens_hsa049200.28233615
152Insulin resistance_Homo sapiens_hsa049310.28046844
153Melanogenesis_Homo sapiens_hsa049160.25385740
154Phosphatidylinositol signaling system_Homo sapiens_hsa040700.24762075
155GnRH signaling pathway_Homo sapiens_hsa049120.24227413

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