HOXC10

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: This gene belongs to the homeobox family of genes. The homeobox genes encode a highly conserved family of transcription factors that play an important role in morphogenesis in all multicellular organisms. Mammals possess four similar homeobox gene clusters, HOXA, HOXB, HOXC and HOXD, which are located on different chromosomes and consist of 9 to 11 genes arranged in tandem. This gene is one of several homeobox HOXC genes located in a cluster on chromosome 12. The protein level is controlled during cell differentiation and proliferation, which may indicate this protein has a role in origin activation. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1proline biosynthetic process (GO:0006561)6.73258851
2transcription from mitochondrial promoter (GO:0006390)5.14496073
3establishment of apical/basal cell polarity (GO:0035089)5.11798556
4proline metabolic process (GO:0006560)5.05286412
5embryonic skeletal joint morphogenesis (GO:0060272)4.99342268
6embryonic process involved in female pregnancy (GO:0060136)4.95876361
7response to muscle activity (GO:0014850)4.95387023
8organ induction (GO:0001759)4.75617993
9* proximal/distal pattern formation (GO:0009954)4.73816919
10actin-myosin filament sliding (GO:0033275)4.55957382
11muscle filament sliding (GO:0030049)4.55957382
12establishment of monopolar cell polarity (GO:0061162)4.53709449
13establishment or maintenance of monopolar cell polarity (GO:0061339)4.53709449
14paraxial mesoderm development (GO:0048339)4.45089073
15mesenchymal to epithelial transition involved in metanephros morphogenesis (GO:0003337)4.40824026
16response to stimulus involved in regulation of muscle adaptation (GO:0014874)4.37808042
17sarcomere organization (GO:0045214)4.34895646
18kidney mesenchyme development (GO:0072074)4.29656160
19skeletal muscle contraction (GO:0003009)4.27325882
20metanephric mesenchyme development (GO:0072075)4.18703230
21regulation of skeletal muscle contraction (GO:0014819)4.14971652
22oxidative demethylation (GO:0070989)4.10728739
23striated muscle contraction (GO:0006941)4.09829415
24creatine metabolic process (GO:0006600)4.09319020
25positive regulation of protein homooligomerization (GO:0032464)4.07704434
26myotube cell development (GO:0014904)4.04988743
27skeletal muscle tissue development (GO:0007519)4.03413267
28convergent extension (GO:0060026)4.01098200
29negative regulation of endoplasmic reticulum calcium ion concentration (GO:0032471)4.00747049
30myofibril assembly (GO:0030239)3.96016994
31replication fork processing (GO:0031297)3.94427083
32embryonic camera-type eye development (GO:0031076)3.90571276
33outer ear morphogenesis (GO:0042473)3.89218801
34regulation of integrin activation (GO:0033623)3.86607516
35muscle cell cellular homeostasis (GO:0046716)3.83082513
36face development (GO:0060324)3.75109199
37actin-mediated cell contraction (GO:0070252)3.72218532
38polarized epithelial cell differentiation (GO:0030859)3.65927792
39muscle organ morphogenesis (GO:0048644)3.65817577
40negative regulation of mRNA splicing, via spliceosome (GO:0048025)3.60715280
41negative regulation of cell size (GO:0045792)3.60005394
42muscle contraction (GO:0006936)3.58779332
43labyrinthine layer development (GO:0060711)3.58373363
44muscle cell fate commitment (GO:0042693)3.54673970
45COPI coating of Golgi vesicle (GO:0048205)3.54235692
46Golgi transport vesicle coating (GO:0048200)3.54235692
47plasma membrane repair (GO:0001778)3.51122346
48glycogen biosynthetic process (GO:0005978)3.49572004
49glucan biosynthetic process (GO:0009250)3.49572004
50negative regulation of cell cycle arrest (GO:0071157)3.47207467
51positive regulation of ryanodine-sensitive calcium-release channel activity (GO:0060316)3.46287320
52skeletal muscle adaptation (GO:0043501)3.44492893
53positive regulation of mitochondrial calcium ion concentration (GO:0051561)3.43916915
54spliceosomal tri-snRNP complex assembly (GO:0000244)3.43024437
55negative regulation of chondrocyte differentiation (GO:0032331)3.42601351
56regulation of relaxation of muscle (GO:1901077)3.40066402
57regulation of protein homooligomerization (GO:0032462)3.39924333
58regulation of organ formation (GO:0003156)3.39760918
59negative regulation of Ras GTPase activity (GO:0034261)3.38870794
60NADH metabolic process (GO:0006734)3.36732477
61positive regulation of myotube differentiation (GO:0010831)3.35615324
62regulation of translational fidelity (GO:0006450)3.35201551
63mesenchymal to epithelial transition (GO:0060231)3.34967114
64focal adhesion assembly (GO:0048041)3.31708583
65cell-substrate adherens junction assembly (GO:0007045)3.31708583
66cartilage development involved in endochondral bone morphogenesis (GO:0060351)3.27282050
67negative regulation of mRNA processing (GO:0050686)3.27017704
68negative regulation of JAK-STAT cascade (GO:0046426)3.26383366
69mitotic G1 DNA damage checkpoint (GO:0031571)3.26263005
70negative regulation of cartilage development (GO:0061037)3.24177573
71planar cell polarity pathway involved in neural tube closure (GO:0090179)3.24124022
72actomyosin structure organization (GO:0031032)3.22258224
73mitochondrial DNA metabolic process (GO:0032042)3.21661891
74cochlea morphogenesis (GO:0090103)3.21625911
75metanephros development (GO:0001656)3.20303439
76viral mRNA export from host cell nucleus (GO:0046784)3.17127060
77skeletal muscle fiber development (GO:0048741)3.16113568
78tricarboxylic acid cycle (GO:0006099)3.15571186
79glycogen catabolic process (GO:0005980)3.13226265
80anterior/posterior axis specification, embryo (GO:0008595)3.12614252
81protein hydroxylation (GO:0018126)3.12604524
82gluconeogenesis (GO:0006094)3.12223316
83DNA strand renaturation (GO:0000733)3.12167713
84peptidyl-proline hydroxylation (GO:0019511)3.10768475
85glial cell migration (GO:0008347)3.09414417
86cardiac myofibril assembly (GO:0055003)3.07877842
87muscle system process (GO:0003012)3.07666010
88response to inactivity (GO:0014854)3.06351300
89maintenance of fidelity involved in DNA-dependent DNA replication (GO:0045005)3.05944022
90somatic hypermutation of immunoglobulin genes (GO:0016446)3.05512910
91somatic diversification of immune receptors via somatic mutation (GO:0002566)3.05512910
92adherens junction assembly (GO:0034333)3.04062939
93muscle fiber development (GO:0048747)3.03004471
94lateral sprouting from an epithelium (GO:0060601)3.02295971
95developmental induction (GO:0031128)3.01320216
96protein retention in ER lumen (GO:0006621)2.99077723
97middle ear morphogenesis (GO:0042474)2.97928923
98myoblast fusion (GO:0007520)2.97531617
99regulation of establishment of planar polarity involved in neural tube closure (GO:0090178)2.97317954
100actin filament-based movement (GO:0030048)2.96951489
101muscle organ development (GO:0007517)2.96711728
102embryonic cranial skeleton morphogenesis (GO:0048701)2.96243143
103cranial nerve morphogenesis (GO:0021602)2.96125811
104pre-miRNA processing (GO:0031054)2.94317541
105G1 DNA damage checkpoint (GO:0044783)2.94210111
106maintenance of protein localization in endoplasmic reticulum (GO:0035437)2.94172374
107protein heterotrimerization (GO:0070208)2.93691552
108muscle structure development (GO:0061061)2.93674637
109anatomical structure regression (GO:0060033)2.92556008
110AMP metabolic process (GO:0046033)2.92333342
111cardiac muscle contraction (GO:0060048)2.91145356
112IMP metabolic process (GO:0046040)2.89925395
113poly(A)+ mRNA export from nucleus (GO:0016973)2.89780290
114cell-cell signaling involved in cell fate commitment (GO:0045168)2.89056192
115sarcoplasmic reticulum calcium ion transport (GO:0070296)2.88300465
116glucan catabolic process (GO:0009251)2.88182585
117hexose biosynthetic process (GO:0019319)2.87451321
118IMP biosynthetic process (GO:0006188)2.85464124
119base-excision repair (GO:0006284)2.84278761
120desmosome organization (GO:0002934)2.84043445
1214-hydroxyproline metabolic process (GO:0019471)2.83771653
122striated muscle tissue development (GO:0014706)2.82573357
123regulation of mitotic spindle organization (GO:0060236)2.82566460
124embryonic placenta development (GO:0001892)2.82099786
125regulation of RNA export from nucleus (GO:0046831)2.81842136
126regulation of stem cell maintenance (GO:2000036)2.80616469
127hindlimb morphogenesis (GO:0035137)2.79893782
128hippo signaling (GO:0035329)2.78757341
129glycogen metabolic process (GO:0005977)2.78744786
130formation of translation preinitiation complex (GO:0001731)2.77845175
131mRNA cleavage (GO:0006379)2.74126911
132regulation of sister chromatid cohesion (GO:0007063)2.73261472
133polysaccharide catabolic process (GO:0000272)2.71560669
134mitotic G1/S transition checkpoint (GO:0044819)2.71485248
135DNA topological change (GO:0006265)2.71433537
136regulation of hippo signaling (GO:0035330)2.70987881
137positive regulation by host of viral transcription (GO:0043923)2.70888918
138carnitine shuttle (GO:0006853)2.70751085
139DNA deamination (GO:0045006)2.70585369
140glucan metabolic process (GO:0044042)2.70084503
141cellular glucan metabolic process (GO:0006073)2.70084503
142negative regulation of RNA splicing (GO:0033119)2.68204525
143skeletal muscle tissue regeneration (GO:0043403)2.65321841
144regulation of single stranded viral RNA replication via double stranded DNA intermediate (GO:00450912.65236976
145muscle tissue morphogenesis (GO:0060415)2.64982184
146cellular polysaccharide catabolic process (GO:0044247)2.64364918
147mammary gland epithelial cell differentiation (GO:0060644)2.62852609
148embryonic skeletal system morphogenesis (GO:0048704)2.62852457
149mitotic chromosome condensation (GO:0007076)2.62672910
150positive regulation of mitotic metaphase/anaphase transition (GO:0045842)2.62276292
151positive regulation of metaphase/anaphase transition of cell cycle (GO:1902101)2.62276292
152positive regulation of mitotic sister chromatid separation (GO:1901970)2.62276292
153dosage compensation (GO:0007549)2.61670072
154syncytium formation by plasma membrane fusion (GO:0000768)2.61574079
155regulation of posttranscriptional gene silencing (GO:0060147)2.61419665
156regulation of gene silencing by miRNA (GO:0060964)2.61419665
157regulation of gene silencing by RNA (GO:0060966)2.61419665
158regulation of cardioblast proliferation (GO:0003264)2.60906127
159regulation of secondary heart field cardioblast proliferation (GO:0003266)2.60906127
160barbed-end actin filament capping (GO:0051016)2.58852295
161muscle tissue development (GO:0060537)2.57763482
162embryonic forelimb morphogenesis (GO:0035115)2.57488489
163muscle atrophy (GO:0014889)2.55963999
164NLS-bearing protein import into nucleus (GO:0006607)2.55057257
165cell migration involved in heart development (GO:0060973)2.52654744
166striated muscle cell development (GO:0055002)2.52367139
167myoblast migration (GO:0051451)2.51993689
168regulation of release of sequestered calcium ion into cytosol by sarcoplasmic reticulum (GO:0010880)2.51734231
169retrograde vesicle-mediated transport, Golgi to ER (GO:0006890)2.50568377
170negative regulation of necroptotic process (GO:0060546)2.49674128
171cell-substrate junction assembly (GO:0007044)2.48802148
172fructose metabolic process (GO:0006000)2.47603377
173monosaccharide biosynthetic process (GO:0046364)2.45388107
174polysaccharide biosynthetic process (GO:0000271)2.43927368

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1ZFP281_18358816_ChIP-ChIP_MESCs_Mouse3.75312001
2* ESR1_20079471_ChIP-ChIP_T-47D_Human3.49957702
3KLF5_18264089_ChIP-ChIP_MESCs_Mouse3.30859825
4KLF4_18264089_ChIP-ChIP_MESCs_Mouse3.30859825
5KLF2_18264089_ChIP-ChIP_MESCs_Mouse3.30859825
6NANOG_18700969_ChIP-ChIP_MESCs_Mouse2.85672275
7SMAD3_22036565_ChIP-Seq_ESCs_Mouse2.46908952
8FOXM1_23109430_ChIP-Seq_U2OS_Human2.42043156
9MYC_18555785_ChIP-Seq_MESCs_Mouse2.38124653
10TRP63_18441228_ChIP-ChIP_KERATINOCYTES_Mouse2.32743257
11ZFP281_18757296_ChIP-ChIP_E14_Mouse2.30274009
12SMAD1_18555785_ChIP-Seq_MESCs_Mouse2.19976100
13SOX2_18358816_ChIP-ChIP_MESCs_Mouse2.10672407
14CTNNB1_24651522_ChIP-Seq_LGR5+_INTESTINAL_STEM_Human2.09359285
15EKLF_21900194_ChIP-Seq_ERYTHROCYTE_Mouse2.07179248
16ZNF652_21678463_ChIP-ChIP_ZR75-1_Human2.07028145
17DACH1_20351289_ChIP-Seq_MDA-MB-231_Human2.04499659
18RARG_19884340_ChIP-ChIP_MEFs_Mouse2.03157673
19* TP53_20018659_ChIP-ChIP_R1E_Mouse2.01743309
20THRA_23701648_ChIP-Seq_CEREBELLUM_Mouse1.96775500
21KLF4_18358816_ChIP-ChIP_MESCs_Mouse1.92769024
22HCFC1_20581084_ChIP-Seq_MESCs_Mouse1.92506132
23LXR_22292898_ChIP-Seq_THP-1_Human1.91065404
24MYBL1_21750041_ChIP-ChIP_SPERMATOCYTES_Mouse1.89877521
25SALL4_18804426_ChIP-ChIP_MESCs_Mouse1.86624397
26NUCKS1_24931609_ChIP-Seq_HEPATOCYTES_Mouse1.84256352
27POU5F1_16518401_ChIP-PET_MESCs_Mouse1.84181538
28VDR_21846776_ChIP-Seq_THP-1_Human1.82965298
29TCF3_18692474_ChIP-Seq_MEFs_Mouse1.81478901
30TP63_17297297_ChIP-ChIP_HaCaT_Human1.81305544
31ZIC3_20872845_ChIP-ChIP_MESCs_Mouse1.77759713
32ZFP281_27345836_Chip-Seq_ESCs_Mouse1.77436556
33CREB1_26743006_Chip-Seq_LNCaP-abl_Human1.75857155
34AR_21909140_ChIP-Seq_LNCAP_Human1.75548228
35ERG_21242973_ChIP-ChIP_JURKAT_Human1.74055619
36PPARD_23176727_ChIP-Seq_KERATINOCYTES_Mouse1.71441684
37EZH2_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse1.71255896
38CCND1_20090754_ChIP-ChIP_RETINA_Mouse1.70330212
39* RACK7_27058665_Chip-Seq_MCF-7_Human1.70228157
40HOXD13_18407260_ChIP-ChIP_DEVELOPING-LIMBS_Mouse1.69886202
41MYC_19079543_ChIP-ChIP_MESCs_Mouse1.68859276
42TRIM28_21343339_ChIP-Seq_HEK293_Human1.67898299
43NANOG_21062744_ChIP-ChIP_HESCs_Human1.66602945
44MEF2A_21415370_ChIP-Seq_HL-1_Mouse1.64051964
45BCL3_23251550_ChIP-Seq_MUSCLE_Mouse1.62920508
46TCF3_18692474_ChIP-Seq_MESCs_Mouse1.62435365
47TBX20_22080862_ChIP-Seq_HEART_Mouse1.60449750
48TBX20_22328084_ChIP-Seq_HEART_Mouse1.60449750
49ELK3_25401928_ChIP-Seq_HUVEC_Human1.60122993
50STAT3_1855785_ChIP-Seq_MESCs_Mouse1.59634907
51RUNX1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.58033072
52HIF1A_21447827_ChIP-Seq_MCF-7_Human1.52921850
53TCF21_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human1.52513215
54TBP_23326641_ChIP-Seq_C3H10T1-2_Mouse1.51819786
55RUNX2_24764292_ChIP-Seq_MC3T3_Mouse1.51804249
56P300_27058665_Chip-Seq_ZR-75-30cells_Human1.51306639
57* NR0B1_18358816_ChIP-ChIP_MESCs_Mouse1.51022935
58KDM2B_26808549_Chip-Seq_DND41_Human1.51000722
59XRN2_22483619_ChIP-Seq_HELA_Human1.50796001
60MYC_22102868_ChIP-Seq_BL_Human1.50013494
61WT1_20215353_ChIP-ChIP_NEPHRON_PROGENITOR_Mouse1.49939542
62NACC1_18358816_ChIP-ChIP_MESCs_Mouse1.48101945
63ESRRB_18555785_ChIP-Seq_MESCs_Mouse1.46908469
64NANOG_18347094_ChIP-ChIP_MESCs_Mouse1.45637093
65SREBP1_19666523_ChIP-Seq_LIVER_Mouse1.45246369
66UBF1/2_26484160_Chip-Seq_HMECs_Human1.44812909
67ESR1_15608294_ChIP-ChIP_MCF-7_Human1.43370678
68CEBPB_21427703_ChIP-Seq_3T3-L1_Mouse1.42456219
69KDM2B_26808549_Chip-Seq_SUP-B15_Human1.41670396
70POU5F1_18700969_ChIP-ChIP_MESCs_Mouse1.41457743
71TFAP2C_20629094_ChIP-Seq_MCF-7_Human1.40430295
72MYC_19030024_ChIP-ChIP_MESCs_Mouse1.37690420
73MYC_18358816_ChIP-ChIP_MESCs_Mouse1.37654119
74E2F7_22180533_ChIP-Seq_HELA_Human1.37475570
75TP63_19390658_ChIP-ChIP_HaCaT_Human1.36176267
76FOXM1_25889361_ChIP-Seq_OE33_AND_U2OS_Human1.35995587
77GATA4_21415370_ChIP-Seq_HL-1_Mouse1.34890997
78ZNF263_19887448_ChIP-Seq_K562_Human1.34214551
79JARID1A_20064375_ChIP-Seq_MESCs_Mouse1.33225073
80TET1_21451524_ChIP-Seq_MESCs_Mouse1.32511985
81UBF1/2_26484160_Chip-Seq_HMEC-DERIVED_Human1.32455146
82SMAD3_18955504_ChIP-ChIP_HaCaT_Human1.32317447
83SMAD2_18955504_ChIP-ChIP_HaCaT_Human1.32317447
84HSF1_23293686_ChIP-Seq_STHDH_STRIATAL_Mouse1.32285143
85DMRT1_21621532_ChIP-ChIP_FETAL_Ovary1.31698765
86* EP300_20729851_ChIP-Seq_FORBRAIN_MIDBRAIN_LIMB_HEART_Mouse1.31664790
87TBX5_21415370_ChIP-Seq_HL-1_Mouse1.29447890
88* CREB1_23762244_ChIP-Seq_HIPPOCAMPUS_Rat1.28702777
89KLF4_26769127_Chip-Seq_PDAC-Cell_line_Human1.28161746
90KLF4_18555785_ChIP-Seq_MESCs_Mouse1.28151586
91ATF3_23680149_ChIP-Seq_GBM1-GSC_Human1.24233769
92DCP1A_22483619_ChIP-Seq_HELA_Human1.23897305
93ESR1_17901129_ChIP-ChIP_LIVER_Mouse1.23418140
94SOX2_18692474_ChIP-Seq_MEFs_Mouse1.21411354
95SOX2_18555785_ChIP-Seq_MESCs_Mouse1.21196559
96TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat1.20986439
97OCT4_18692474_ChIP-Seq_MEFs_Mouse1.20283105
98STAT3_19079543_ChIP-ChIP_MESCs_Mouse1.18886751
99* CTCF_21964334_ChIP-Seq_BJAB-B_Human1.18585282
100CLOCK_20551151_ChIP-Seq_293T_Human1.18153623
101ELF3_26769127_Chip-Seq_PDAC-Cell_line_Human1.18114384
102KDM2B_26808549_Chip-Seq_SIL-ALL_Human1.17343225
103* RING1B_27294783_Chip-Seq_NPCs_Mouse1.16997632
104PPARG_19300518_ChIP-PET_3T3-L1_Mouse1.16943591
105CTCF_27219007_Chip-Seq_ERYTHROID_Human1.16747366
106TCFAP2C_20176728_ChIP-ChIP_TROPHOBLAST_STEM_CELLS_Mouse1.16549879
107TAF7L_23326641_ChIP-Seq_C3H10T1-2_Mouse1.16442796
108KDM2B_26808549_Chip-Seq_HPB-ALL_Human1.16428151
109TCF3_18347094_ChIP-ChIP_MESCs_Mouse1.15214197
110KLF6_26769127_Chip-Seq_PDAC-Cell_line_Human1.14361159
111* KLF4_19030024_ChIP-ChIP_MESCs_Mouse1.12445535
112CHD1_26751641_Chip-Seq_LNCaP_Human1.12370727
113CREB1_26743006_Chip-Seq_LNCaP_Human1.12353285
114POU5F1_18358816_ChIP-ChIP_MESCs_Mouse1.12081435
115KDM5A_27292631_Chip-Seq_BREAST_Human1.11767022
116SMC3_22415368_ChIP-Seq_MEFs_Mouse1.11395018
117TP53_22127205_ChIP-Seq_IMR90_Human1.11367974
118EOMES_20176728_ChIP-ChIP_TSCs_Mouse1.11114454
119THAP11_20581084_ChIP-Seq_MESCs_Mouse1.11069268
120SMAD4_19686287_ChIP-ChIP_HaCaT_Human1.11042495
121MYCN_18555785_ChIP-Seq_MESCs_Mouse1.10982457
122ATF3_27146783_Chip-Seq_COLON_Human1.10945131
123KDM2B_26808549_Chip-Seq_K562_Human1.10415138
124TCF3_18467660_ChIP-ChIP_MESCs_Mouse1.09133002
125CDX2_20551321_ChIP-Seq_CACO-2_Human1.08122546
126PRDM16_22522345_ChIP-ChIP_PALATE_MESENCHYMAL_Mouse1.07161991
127CEBPB_24764292_ChIP-Seq_MC3T3_Mouse1.06538538
128ESR1_21235772_ChIP-Seq_MCF-7_Human1.06508183
129SMC4_20622854_ChIP-Seq_HELA_Human1.06025673
130ESR2_21235772_ChIP-Seq_MCF-7_Human1.05845835
131TRIM28_19339689_ChIP-ChIP_MESCs_Mouse1.05750244
132CNOT3_19339689_ChIP-ChIP_MESCs_Mouse1.05373901
133SMC1_22415368_ChIP-Seq_MEFs_Mouse1.05270892
134POU5F1_18692474_ChIP-Seq_MESCs_Mouse1.04546957
135ZFX_18555785_ChIP-Seq_MESCs_Mouse1.04305409
136TFEB_21752829_ChIP-Seq_HELA_Human1.03630460
137SREBP2_21459322_ChIP-Seq_LIVER_Mouse1.02323755
138NFIB_24661679_ChIP-Seq_LUNG_Mouse1.02177405
139PRDM14_21183938_ChIP-Seq_MESCs_Mouse1.01058072
140* CREB1_20920259_ChIP-Seq_GC1-SPG_Mouse0.99771824
141SMARCA4_20176728_ChIP-ChIP_TSCs_Mouse0.99759197
142SA1_27219007_Chip-Seq_ERYTHROID_Human0.99543040
143NKX2-5_21415370_ChIP-Seq_HL-1_Mouse0.98996327
144NELFA_20434984_ChIP-Seq_ESCs_Mouse0.98485241
145SOX9_25088423_ChIP-ChIP_EMBRYONIC_GONADS_Mouse0.98267080
146MYCN_27167114_Chip-Seq_NEUROBLASTOMA_Human0.97605255
147RUNX1_27514584_Chip-Seq_MCF-7_Human0.97244785

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0010030_abnormal_orbit_morphology4.53791285
2MP0004145_abnormal_muscle_electrophysio4.20104542
3MP0000751_myopathy3.22476488
4MP0003950_abnormal_plasma_membrane2.90058644
5MP0000749_muscle_degeneration2.73682643
6MP0005451_abnormal_body_composition2.65347566
7MP0000733_abnormal_muscle_development2.51210714
8* MP0004233_abnormal_muscle_weight2.48408406
9MP0003942_abnormal_urinary_system2.45673173
10MP0008057_abnormal_DNA_replication2.42989388
11* MP0000759_abnormal_skeletal_muscle2.42518867
12MP0001346_abnormal_lacrimal_gland2.40605920
13MP0000747_muscle_weakness2.39363776
14MP0002249_abnormal_larynx_morphology2.37592961
15MP0009278_abnormal_bone_marrow2.35022211
16MP0009053_abnormal_anal_canal2.32195799
17MP0002108_abnormal_muscle_morphology2.29215527
18MP0002106_abnormal_muscle_physiology2.25928421
19* MP0002269_muscular_atrophy2.25853165
20MP0000534_abnormal_ureter_morphology2.14851682
21MP0000013_abnormal_adipose_tissue2.13926477
22MP0003385_abnormal_body_wall2.12458046
23MP0005369_muscle_phenotype2.12253657
24MP0002932_abnormal_joint_morphology2.09584406
25MP0005503_abnormal_tendon_morphology2.07114172
26MP0002282_abnormal_trachea_morphology2.05062811
27MP0003705_abnormal_hypodermis_morpholog2.05022310
28MP0009780_abnormal_chondrocyte_physiolo2.02648343
29MP0000750_abnormal_muscle_regeneration1.97574027
30* MP0009250_abnormal_appendicular_skeleto1.95765684
31MP0004087_abnormal_muscle_fiber1.95539653
32MP0005171_absent_coat_pigmentation1.90361084
33MP0008438_abnormal_cutaneous_collagen1.90319895
34MP0004084_abnormal_cardiac_muscle1.88423975
35MP0000003_abnormal_adipose_tissue1.81730434
36MP0003646_muscle_fatigue1.73010040
37MP0002877_abnormal_melanocyte_morpholog1.61516724
38* MP0002114_abnormal_axial_skeleton1.60211648
39MP0000762_abnormal_tongue_morphology1.56106511
40MP0004197_abnormal_fetal_growth/weight/1.54314931
41MP0005076_abnormal_cell_differentiation1.54072108
42MP0001661_extended_life_span1.51996912
43MP0003755_abnormal_palate_morphology1.50058671
44MP0003119_abnormal_digestive_system1.50006384
45MP0005623_abnormal_meninges_morphology1.49332247
46MP0002653_abnormal_ependyma_morphology1.48532066
47MP0005508_abnormal_skeleton_morphology1.47194587
48MP0000049_abnormal_middle_ear1.44470115
49MP0010352_gastrointestinal_tract_polyps1.42076716
50MP0000516_abnormal_urinary_system1.39371806
51MP0005367_renal/urinary_system_phenotyp1.39371806
52MP0003123_paternal_imprinting1.38439291
53MP0004134_abnormal_chest_morphology1.34838213
54MP0002085_abnormal_embryonic_tissue1.34676940
55MP0005375_adipose_tissue_phenotype1.32685299
56MP0002084_abnormal_developmental_patter1.31234670
57MP0004130_abnormal_muscle_cell1.23547255
58MP0002116_abnormal_craniofacial_bone1.22975937
59* MP0002111_abnormal_tail_morphology1.22620764
60MP0001697_abnormal_embryo_size1.20357622
61MP0002972_abnormal_cardiac_muscle1.17684392
62MP0003283_abnormal_digestive_organ1.17679263
63MP0008932_abnormal_embryonic_tissue1.12614585
64MP0003937_abnormal_limbs/digits/tail_de1.12366608
65MP0003935_abnormal_craniofacial_develop1.11437503
66MP0003567_abnormal_fetal_cardiomyocyte1.11384763
67MP0006138_congestive_heart_failure1.11301245
68MP0005620_abnormal_muscle_contractility1.09651092
69MP0009384_cardiac_valve_regurgitation1.08835353
70MP0002060_abnormal_skin_morphology1.08139649
71MP0004957_abnormal_blastocyst_morpholog1.08034272
72MP0004185_abnormal_adipocyte_glucose1.07535103
73* MP0002109_abnormal_limb_morphology1.07466906
74MP0004858_abnormal_nervous_system1.07213301
75MP0005670_abnormal_white_adipose1.07009417
76MP0006036_abnormal_mitochondrial_physio1.06541941
77MP0002086_abnormal_extraembryonic_tissu1.05257381
78MP0010630_abnormal_cardiac_muscle1.05097802
79MP0001293_anophthalmia1.04488288
80MP0002089_abnormal_postnatal_growth/wei1.04316423
81MP0005275_abnormal_skin_tensile1.04269640
82MP0004133_heterotaxia1.03485360
83MP0010094_abnormal_chromosome_stability1.02998598
84MP0001340_abnormal_eyelid_morphology1.02507096
85MP0002009_preneoplasia1.02358488
86MP0002796_impaired_skin_barrier1.01758178
87MP0003941_abnormal_skin_development1.01051436
88MP0005083_abnormal_biliary_tract1.00482364
89MP0001299_abnormal_eye_distance/0.99800903
90MP0005330_cardiomyopathy0.98261894
91MP0003115_abnormal_respiratory_system0.97290703
92MP0000432_abnormal_head_morphology0.96421217
93MP0005501_abnormal_skin_physiology0.96339514
94MP0004036_abnormal_muscle_relaxation0.95655578
95* MP0002115_abnormal_skeleton_extremities0.94826735
96MP0002332_abnormal_exercise_endurance0.94131032
97MP0005380_embryogenesis_phenotype0.93716832
98MP0001672_abnormal_embryogenesis/_devel0.93716832
99MP0000579_abnormal_nail_morphology0.93027421
100MP0000678_abnormal_parathyroid_gland0.90881606
101MP0003890_abnormal_embryonic-extraembry0.90805243
102MP0010234_abnormal_vibrissa_follicle0.90429072
103MP0000537_abnormal_urethra_morphology0.88259863
104MP0001730_embryonic_growth_arrest0.86666083
105MP0003221_abnormal_cardiomyocyte_apopto0.85329422
106* MP0002896_abnormal_bone_mineralization0.84729069
107MP0001958_emphysema0.84346819
108MP0003111_abnormal_nucleus_morphology0.84096029
109MP0002971_abnormal_brown_adipose0.80977694
110MP0000428_abnormal_craniofacial_morphol0.80564885
111MP0002127_abnormal_cardiovascular_syste0.80542015
112MP0001879_abnormal_lymphatic_vessel0.80323627
113* MP0000163_abnormal_cartilage_morphology0.79800289
114MP0000350_abnormal_cell_proliferation0.79435713
115MP0000266_abnormal_heart_morphology0.79036090
116MP0005023_abnormal_wound_healing0.78342789
117MP0000681_abnormal_thyroid_gland0.77125679
118MP0003279_aneurysm0.76813211
119MP0001849_ear_inflammation0.76438104
120MP0005385_cardiovascular_system_phenoty0.76414100
121MP0001544_abnormal_cardiovascular_syste0.76414100
122MP0001243_abnormal_dermal_layer0.76126287
123MP0000467_abnormal_esophagus_morphology0.76090168
124MP0000627_abnormal_mammary_gland0.75840651
125MP0000767_abnormal_smooth_muscle0.75167494
126MP0005248_abnormal_Harderian_gland0.75159231
127MP0003566_abnormal_cell_adhesion0.74441934
128MP0004272_abnormal_basement_membrane0.74018351
129MP0002080_prenatal_lethality0.73772427
130MP0003984_embryonic_growth_retardation0.73407943
131MP0009115_abnormal_fat_cell0.73254777
132MP0003938_abnormal_ear_development0.72181183
133MP0005666_abnormal_adipose_tissue0.72064770
134MP0002925_abnormal_cardiovascular_devel0.71958390
135MP0001881_abnormal_mammary_gland0.71807907
136MP0001348_abnormal_lacrimal_gland0.70479705
137MP0001542_abnormal_bone_strength0.69778922
138MP0010368_abnormal_lymphatic_system0.68019536
139MP0002160_abnormal_reproductive_system0.66098778
140MP0003191_abnormal_cellular_cholesterol0.65478959
141MP0003045_fibrosis0.63829408
142MP0005266_abnormal_metabolism0.63634502
143MP0005257_abnormal_intraocular_pressure0.57865641
144MP0002234_abnormal_pharynx_morphology0.54600180
145MP0002113_abnormal_skeleton_development0.54324809

Predicted human phenotypes

RankGene SetZ-score
1Muscle fiber inclusion bodies (HP:0100299)6.18278183
2Muscle fiber cytoplasmatic inclusion bodies (HP:0100303)5.99238185
3Nemaline bodies (HP:0003798)5.55999108
4Exercise-induced myalgia (HP:0003738)5.43152339
5Calcaneovalgus deformity (HP:0001848)5.35003059
6Type 1 muscle fiber predominance (HP:0003803)5.02542941
7Deformed tarsal bones (HP:0008119)4.93060216
8Distal arthrogryposis (HP:0005684)4.71022937
9Round ear (HP:0100830)4.67279706
10Exercise-induced muscle cramps (HP:0003710)4.53953905
11Myopathic facies (HP:0002058)4.14638842
12Ulnar deviation of the wrist (HP:0003049)4.14441803
13Centrally nucleated skeletal muscle fibers (HP:0003687)3.78898035
14Abnormality of the calcaneus (HP:0008364)3.68243146
15Rib fusion (HP:0000902)3.62672003
16Muscle hypertrophy of the lower extremities (HP:0008968)3.53836694
17Absent phalangeal crease (HP:0006109)3.36925167
18Increased connective tissue (HP:0009025)3.29029601
19Ulnar bowing (HP:0003031)3.28116891
20Myoglobinuria (HP:0002913)3.21508076
21Difficulty running (HP:0009046)3.17278273
22Muscle fiber splitting (HP:0003555)3.15391402
23Coronal craniosynostosis (HP:0004440)3.09244903
24Turricephaly (HP:0000262)3.08751030
25Malignant hyperthermia (HP:0002047)3.06552361
26Muscle stiffness (HP:0003552)3.05344516
27Calf muscle hypertrophy (HP:0008981)2.99835232
28Rectal fistula (HP:0100590)2.98358434
29Rectovaginal fistula (HP:0000143)2.98358434
30Difficulty climbing stairs (HP:0003551)2.82661378
31Distal lower limb amyotrophy (HP:0008944)2.79882765
32Protrusio acetabuli (HP:0003179)2.79762151
33Congenital hip dislocation (HP:0001374)2.76902446
34Myotonia (HP:0002486)2.76167483
35Hyporeflexia of lower limbs (HP:0002600)2.66351956
36Progressive muscle weakness (HP:0003323)2.66335599
37Abnormal finger flexion creases (HP:0006143)2.64872087
38Intestinal fistula (HP:0100819)2.63297468
39Neck muscle weakness (HP:0000467)2.59846355
40EMG: myopathic abnormalities (HP:0003458)2.58696013
41Sparse lateral eyebrow (HP:0005338)2.57827554
42Vaginal fistula (HP:0004320)2.56372104
43Areflexia of lower limbs (HP:0002522)2.55226110
44Rimmed vacuoles (HP:0003805)2.53817753
45Hypoplastic ischia (HP:0003175)2.52570691
46Abnormality of the calf musculature (HP:0001430)2.50425320
47Concave nail (HP:0001598)2.45206546
48Rhabdomyolysis (HP:0003201)2.41178854
49Shoulder girdle muscle weakness (HP:0003547)2.39084467
50Aplasia/Hypoplasia of the pubic bone (HP:0009104)2.37936336
51Pelvic girdle muscle weakness (HP:0003749)2.36037949
52Bulbar palsy (HP:0001283)2.35486498
53Annular pancreas (HP:0001734)2.33748272
54Limb-girdle muscle atrophy (HP:0003797)2.33700527
55Fatigable weakness (HP:0003473)2.33682413
56Abnormality of the neuromuscular junction (HP:0003398)2.33682413
57Abnormality of skeletal muscle fiber size (HP:0012084)2.30605523
58Asymmetric septal hypertrophy (HP:0001670)2.28457569
59Abnormality of the aortic arch (HP:0012303)2.24910986
60Gowers sign (HP:0003391)2.23131841
61Spinal rigidity (HP:0003306)2.22472464
62Cerebral aneurysm (HP:0004944)2.21227033
63Fetal akinesia sequence (HP:0001989)2.19298346
64Mesomelia (HP:0003027)2.19063017
65Achilles tendon contracture (HP:0001771)2.18931301
66Abnormality of the ischium (HP:0003174)2.18525992
67Short humerus (HP:0005792)2.17700234
68Alopecia of scalp (HP:0002293)2.17611090
69Hip contracture (HP:0003273)2.17352441
70Abnormality of the musculature of the pelvis (HP:0001469)2.16999115
71Abnormality of the hip-girdle musculature (HP:0001445)2.16999115
72Generalized amyotrophy (HP:0003700)2.14269416
73Facial hemangioma (HP:0000329)2.12686743
74Broad toe (HP:0001837)2.11473720
75Increased variability in muscle fiber diameter (HP:0003557)2.10694874
76EMG: neuropathic changes (HP:0003445)2.10394480
77Reduced subcutaneous adipose tissue (HP:0003758)2.07812121
78Popliteal pterygium (HP:0009756)2.06928358
79Vertebral compression fractures (HP:0002953)2.04487173
80Aplasia/hypoplasia of the humerus (HP:0006507)2.04019383
81Premature rupture of membranes (HP:0001788)2.02724775
82Aplasia of the musculature (HP:0100854)2.02553717
83Sudden death (HP:0001699)2.01141553
84Vertebral fusion (HP:0002948)2.00942140
85Frequent falls (HP:0002359)1.99579192
86Shallow orbits (HP:0000586)1.99144779
87Type 2 muscle fiber atrophy (HP:0003554)1.98840246
88Muscle fiber atrophy (HP:0100295)1.98615690
89Lower limb amyotrophy (HP:0007210)1.96985002
90Amniotic constriction ring (HP:0009775)1.95130613
91Abnormality of placental membranes (HP:0011409)1.95130613
92Lipoatrophy (HP:0100578)1.94237857
93Dilated cardiomyopathy (HP:0001644)1.93373323
94Metatarsus adductus (HP:0001840)1.91645847
95Infantile muscular hypotonia (HP:0008947)1.91441209
96Pancreatic islet-cell hyperplasia (HP:0004510)1.91112466
97Broad thumb (HP:0011304)1.90681608
98Mildly elevated creatine phosphokinase (HP:0008180)1.89855701
99Bundle branch block (HP:0011710)1.89637405
100Abnormality of the Achilles tendon (HP:0005109)1.87615949
101Abnormality of the umbilical cord (HP:0010881)1.86676835
102Ankle contracture (HP:0006466)1.86091933
103Respiratory insufficiency due to muscle weakness (HP:0002747)1.85847972
104Bowing of the arm (HP:0006488)1.85699650
105Bowed forearm bones (HP:0003956)1.85699650
106Slender build (HP:0001533)1.83643681
107Intestinal atresia (HP:0011100)1.82132556
108Lip pit (HP:0100267)1.79932282
109Scapular winging (HP:0003691)1.79361431
110Renal duplication (HP:0000075)1.77692297
111Abnormality of the shoulder girdle musculature (HP:0001435)1.77133696
112Alacrima (HP:0000522)1.76821217
113Aplasia/Hypoplasia involving the carpal bones (HP:0006502)1.73528907
114Abnormality of the left ventricular outflow tract (HP:0011103)1.73148560
115Subaortic stenosis (HP:0001682)1.73148560
116Breech presentation (HP:0001623)1.73089967
117Broad hallux (HP:0010055)1.72992231
118Muscular dystrophy (HP:0003560)1.71880931
119Ventricular tachycardia (HP:0004756)1.71027305
120Choanal stenosis (HP:0000452)1.70894732
121Bell-shaped thorax (HP:0001591)1.70806632
122Trismus (HP:0000211)1.70629901
123Pterygium (HP:0001059)1.70543068
124Anteriorly placed anus (HP:0001545)1.69840545
125Adducted thumb (HP:0001181)1.69364769
126Muscle fibrillation (HP:0010546)1.68612561
127Generalized muscle weakness (HP:0003324)1.68226174
128Weak cry (HP:0001612)1.67771588
129Ragged-red muscle fibers (HP:0003200)1.67163668
130Wrist flexion contracture (HP:0001239)1.66664588
131Selective tooth agenesis (HP:0001592)1.66527406
132Short 5th finger (HP:0009237)1.66352728
133Elbow flexion contracture (HP:0002987)1.65495579
134Distal lower limb muscle weakness (HP:0009053)1.65489185
135Limb-girdle muscle weakness (HP:0003325)1.65022211
136Vascular tortuosity (HP:0004948)1.63481681
137Abnormalities of placenta or umbilical cord (HP:0001194)1.60406173
138Oligomenorrhea (HP:0000876)1.57355544
139Thin ribs (HP:0000883)1.57005823
140Foot dorsiflexor weakness (HP:0009027)1.54323981
141Waddling gait (HP:0002515)1.52868134
142Back pain (HP:0003418)1.51316412
143Abnormal atrioventricular conduction (HP:0005150)1.51126364

Predicted kinase interactions (KEA)

RankGene SetZ-score
1ICK4.59862214
2DDR24.53463013
3MAP3K63.25049292
4PHKG23.19841804
5PHKG13.19841804
6TTN3.17919781
7OBSCN3.10674866
8TRIB32.82867082
9PINK12.69026924
10MAPK152.55435384
11LATS22.52549632
12PDGFRA2.52040149
13MAP3K112.50125181
14MUSK2.41200422
15EEF2K2.12917932
16BMX2.08163279
17PIM21.99560735
18NEK11.97613765
19MAPKAPK31.97167879
20TESK11.87447712
21TYRO31.86120862
22EIF2AK11.77036051
23TAOK21.72185906
24FGR1.70549692
25MAP3K101.64255139
26PDK21.61911820
27MATK1.61807266
28LATS11.60726991
29EPHA21.59183462
30MST1R1.59026509
31ERBB31.58344802
32UHMK11.56676432
33DYRK1B1.53515995
34NME11.49882202
35MOS1.46384037
36TRPM71.45734912
37CDK61.42056411
38PRKD21.39824631
39CDK71.31865592
40PIK3CG1.25818626
41MET1.25274862
42MAP2K31.23096629
43IRAK31.12833905
44PBK1.11052109
45DAPK11.10437394
46MAPK121.06028056
47MAP3K31.04254561
48YES11.03386328
49NME21.02884454
50CDK80.99319193
51MTOR0.99305103
52CSK0.97141939
53MYLK0.96800761
54MAP2K10.92969179
55VRK20.88473453
56DMPK0.87432307
57AKT30.85694751
58MAPK110.85039482
59SMG10.84697910
60RPS6KL10.82923044
61RPS6KC10.82923044
62FGFR10.78640792
63GSK3A0.76749018
64ARAF0.74924938
65PAK20.74083592
66PRPF4B0.73860705
67PRKAA10.73440252
68LRRK20.72389693
69MKNK10.72115218
70CHEK20.71179403
71STK38L0.69294768
72CCNB10.69196012
73STK30.68948124
74MAP3K70.68107644
75RPS6KA60.67635445
76DYRK30.66927969
77PLK10.65174400
78RIPK10.64748881
79CDK90.63837997
80CDC42BPA0.63684269
81CDK120.63362356
82LIMK10.63151569
83KSR20.58642489
84PAK40.57111238
85ABL20.56747331
86PKN20.56673637
87MAP3K120.56652471
88PIM10.55607906
89SCYL20.55277206
90RPS6KA10.54239554
91TESK20.52348355
92MKNK20.52205610
93PRKD30.51928062
94AURKB0.51322021
95PRKAA20.50687679
96PTK20.50559418
97ILK0.50125365
98EPHB10.50069794
99CAMK2D0.48731394
100EPHB20.48207608
101ERN10.47590752
102SIK10.47245059
103BRSK10.46317613
104MAP3K80.44095860
105STK380.43317657
106STK160.42708022
107NTRK10.42611597
108PNCK0.41974596
109BRAF0.41353403
110NEK20.41106741
111AKT20.41074034
112CDK20.40874593
113TAOK10.40846352
114MAP3K130.40792675
115ROCK10.39914562
116BCKDK0.39427640
117PDK30.39078869
118PDK40.39078869
119PAK60.38173967
120PDGFRB0.37718082
121AURKA0.37368224
122BUB10.36448354
123ALK0.35811885
124MAPKAPK50.35600027
125CAMK2G0.34662659
126MAPK70.32908904
127PDPK10.32430492
128CAMK2B0.32415923
129MELK0.31812435
130TTK0.30785728
131WEE10.30598211
132MAPK10.29538302
133PAK10.29423018
134CHEK10.28819487
135CSNK2A10.28652067
136ATR0.27784844
137CDC70.27173937
138HIPK20.26605499
139PRKCI0.26550892
140NEK90.26241415
141PTK60.25429394
142MAPK100.25399342
143CDK10.24926890
144ROCK20.24697897
145CDK140.24697459
146RPS6KB20.23466371
147CDK150.23419817
148MAPKAPK20.23108642
149MAPK140.22548843
150CDK11A0.22287970

Predicted pathways (KEGG)

RankGene SetZ-score
1Fatty acid biosynthesis_Homo sapiens_hsa000613.45057254
2Base excision repair_Homo sapiens_hsa034103.30512944
3Mismatch repair_Homo sapiens_hsa034302.92309999
4Hedgehog signaling pathway_Homo sapiens_hsa043402.74996290
5Hippo signaling pathway_Homo sapiens_hsa043902.59628852
6Basal cell carcinoma_Homo sapiens_hsa052172.56337326
72-Oxocarboxylic acid metabolism_Homo sapiens_hsa012102.42548166
8Adherens junction_Homo sapiens_hsa045202.09181457
9DNA replication_Homo sapiens_hsa030302.06999109
10Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004002.05939692
11Pentose phosphate pathway_Homo sapiens_hsa000302.05256456
12Circadian rhythm_Homo sapiens_hsa047101.97042484
13mTOR signaling pathway_Homo sapiens_hsa041501.92523198
14Arrhythmogenic right ventricular cardiomyopathy (ARVC)_Homo sapiens_hsa054121.90010837
15Biosynthesis of amino acids_Homo sapiens_hsa012301.83519248
16Arginine and proline metabolism_Homo sapiens_hsa003301.82449536
17Notch signaling pathway_Homo sapiens_hsa043301.79962820
18TGF-beta signaling pathway_Homo sapiens_hsa043501.79813205
19Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005331.76615439
20Bladder cancer_Homo sapiens_hsa052191.76489050
21Arginine biosynthesis_Homo sapiens_hsa002201.75402834
22RNA transport_Homo sapiens_hsa030131.72934257
23Hypertrophic cardiomyopathy (HCM)_Homo sapiens_hsa054101.72824477
24Spliceosome_Homo sapiens_hsa030401.71261704
25mRNA surveillance pathway_Homo sapiens_hsa030151.70994423
26Cell cycle_Homo sapiens_hsa041101.54122433
27Wnt signaling pathway_Homo sapiens_hsa043101.51997618
28Nucleotide excision repair_Homo sapiens_hsa034201.48419516
29Tight junction_Homo sapiens_hsa045301.47413488
30Citrate cycle (TCA cycle)_Homo sapiens_hsa000201.46671230
31Focal adhesion_Homo sapiens_hsa045101.46107472
32Insulin signaling pathway_Homo sapiens_hsa049101.44138234
33Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa045501.40682620
34Proteoglycans in cancer_Homo sapiens_hsa052051.38805274
35Viral myocarditis_Homo sapiens_hsa054161.36852165
36Longevity regulating pathway - mammal_Homo sapiens_hsa042111.36252212
37MicroRNAs in cancer_Homo sapiens_hsa052061.34934369
38Dilated cardiomyopathy_Homo sapiens_hsa054141.34065157
39AMPK signaling pathway_Homo sapiens_hsa041521.31739071
40Phenylalanine metabolism_Homo sapiens_hsa003601.30866745
41Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030081.29862744
42Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001301.24798622
43Lysine degradation_Homo sapiens_hsa003101.22803204
44p53 signaling pathway_Homo sapiens_hsa041151.19267571
45Oocyte meiosis_Homo sapiens_hsa041141.18178886
46Fatty acid metabolism_Homo sapiens_hsa012121.14521994
47Transcriptional misregulation in cancer_Homo sapiens_hsa052021.13208472
48Chronic myeloid leukemia_Homo sapiens_hsa052201.11127212
49Fructose and mannose metabolism_Homo sapiens_hsa000511.08564424
50Central carbon metabolism in cancer_Homo sapiens_hsa052301.08456977
51Regulation of actin cytoskeleton_Homo sapiens_hsa048101.07722386
52Glucagon signaling pathway_Homo sapiens_hsa049221.07245034
53Taurine and hypotaurine metabolism_Homo sapiens_hsa004301.03178563
54Ubiquitin mediated proteolysis_Homo sapiens_hsa041201.03152041
55Thyroid cancer_Homo sapiens_hsa052161.02277180
56VEGF signaling pathway_Homo sapiens_hsa043700.97501776
57Galactose metabolism_Homo sapiens_hsa000520.97355188
58Folate biosynthesis_Homo sapiens_hsa007900.96444140
59Colorectal cancer_Homo sapiens_hsa052100.95053713
60Longevity regulating pathway - multiple species_Homo sapiens_hsa042130.93400172
61Fatty acid elongation_Homo sapiens_hsa000620.91067909
62Bacterial invasion of epithelial cells_Homo sapiens_hsa051000.91013372
63Sulfur relay system_Homo sapiens_hsa041220.90711372
64cGMP-PKG signaling pathway_Homo sapiens_hsa040220.90585903
65Shigellosis_Homo sapiens_hsa051310.89961801
66Starch and sucrose metabolism_Homo sapiens_hsa005000.89835308
67Sulfur metabolism_Homo sapiens_hsa009200.88306716
68Carbon metabolism_Homo sapiens_hsa012000.86940512
69Cyanoamino acid metabolism_Homo sapiens_hsa004600.86423863
70Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa049610.83393796
71Small cell lung cancer_Homo sapiens_hsa052220.82935227
72ECM-receptor interaction_Homo sapiens_hsa045120.80670553
73Melanoma_Homo sapiens_hsa052180.78826710
74Glycolysis / Gluconeogenesis_Homo sapiens_hsa000100.78745992
75Cardiac muscle contraction_Homo sapiens_hsa042600.77444249
76HIF-1 signaling pathway_Homo sapiens_hsa040660.76524788
77Homologous recombination_Homo sapiens_hsa034400.76416015
78PI3K-Akt signaling pathway_Homo sapiens_hsa041510.76133990
79Non-small cell lung cancer_Homo sapiens_hsa052230.72060350
80HTLV-I infection_Homo sapiens_hsa051660.71446211
81Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007600.71000003
82Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa005200.69614714
83Calcium signaling pathway_Homo sapiens_hsa040200.69259016
84Thyroid hormone signaling pathway_Homo sapiens_hsa049190.68724947
85Gap junction_Homo sapiens_hsa045400.68071077
86Endometrial cancer_Homo sapiens_hsa052130.66805930
87Alzheimers disease_Homo sapiens_hsa050100.66385552
88Pathways in cancer_Homo sapiens_hsa052000.65651610
89Other types of O-glycan biosynthesis_Homo sapiens_hsa005140.65386755
90Prostate cancer_Homo sapiens_hsa052150.64114276
91Insulin resistance_Homo sapiens_hsa049310.63781891
92Other glycan degradation_Homo sapiens_hsa005110.62643453
93Pyrimidine metabolism_Homo sapiens_hsa002400.62234956
94Regulation of lipolysis in adipocytes_Homo sapiens_hsa049230.60876406
95Renal cell carcinoma_Homo sapiens_hsa052110.60611223
96Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006300.60229857
97Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049320.59237340
98Adipocytokine signaling pathway_Homo sapiens_hsa049200.59008985
99Progesterone-mediated oocyte maturation_Homo sapiens_hsa049140.57753519
100RNA degradation_Homo sapiens_hsa030180.57627820
101Terpenoid backbone biosynthesis_Homo sapiens_hsa009000.57374496
102FoxO signaling pathway_Homo sapiens_hsa040680.57053472
103Melanogenesis_Homo sapiens_hsa049160.56330114
104MAPK signaling pathway_Homo sapiens_hsa040100.55900136
105Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate_Homo sapiens_hsa005320.55273920
106Proteasome_Homo sapiens_hsa030500.54938054
107Purine metabolism_Homo sapiens_hsa002300.54896714
108Propanoate metabolism_Homo sapiens_hsa006400.54106588
109Vasopressin-regulated water reabsorption_Homo sapiens_hsa049620.53689468
110ErbB signaling pathway_Homo sapiens_hsa040120.52590092
111Oxytocin signaling pathway_Homo sapiens_hsa049210.50989891
112Viral carcinogenesis_Homo sapiens_hsa052030.46764517
113Amoebiasis_Homo sapiens_hsa051460.46534391
114One carbon pool by folate_Homo sapiens_hsa006700.46416986
115Pyruvate metabolism_Homo sapiens_hsa006200.46181487
116AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa049330.46032965
117Glycine, serine and threonine metabolism_Homo sapiens_hsa002600.44680828
118Glutathione metabolism_Homo sapiens_hsa004800.43592687
119Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa005340.41898814
120Protein processing in endoplasmic reticulum_Homo sapiens_hsa041410.41676818
121Tyrosine metabolism_Homo sapiens_hsa003500.41625244
122Vibrio cholerae infection_Homo sapiens_hsa051100.41601110
123Acute myeloid leukemia_Homo sapiens_hsa052210.41477493
124Parkinsons disease_Homo sapiens_hsa050120.41091167
125Adrenergic signaling in cardiomyocytes_Homo sapiens_hsa042610.40727272
126Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa009700.39572652
127Fanconi anemia pathway_Homo sapiens_hsa034600.39476210
128Pancreatic cancer_Homo sapiens_hsa052120.39273420
129GnRH signaling pathway_Homo sapiens_hsa049120.37930362
130Choline metabolism in cancer_Homo sapiens_hsa052310.35330066
131Glioma_Homo sapiens_hsa052140.34320945
132Rap1 signaling pathway_Homo sapiens_hsa040150.34235548
133Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002500.32338605
134Legionellosis_Homo sapiens_hsa051340.31699242

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