HOXC12

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: This gene belongs to the homeobox family of genes. The homeobox genes encode a highly conserved family of transcription factors that play an important role in morphogenesis in all multicellular organisms. Mammals possess four similar homeobox gene clusters, HOXA, HOXB, HOXC and HOXD, which are located on different chromosomes and consist of 9 to 11 genes arranged in tandem. This gene is one of several homeobox HOXC genes located in a cluster on chromosome 12. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1transcription from mitochondrial promoter (GO:0006390)8.77114195
2proline metabolic process (GO:0006560)7.86241318
3embryonic process involved in female pregnancy (GO:0060136)7.11217698
4replication fork processing (GO:0031297)6.81089429
5regulation of integrin activation (GO:0033623)6.62165507
6establishment of apical/basal cell polarity (GO:0035089)6.56921668
7positive regulation of protein homooligomerization (GO:0032464)6.17568993
8oxidative demethylation (GO:0070989)5.75558900
9establishment of monopolar cell polarity (GO:0061162)5.69676030
10establishment or maintenance of monopolar cell polarity (GO:0061339)5.69676030
11maintenance of fidelity involved in DNA-dependent DNA replication (GO:0045005)5.68201788
12DNA deamination (GO:0045006)5.65144177
13regulation of protein homooligomerization (GO:0032462)5.40046099
14DNA strand renaturation (GO:0000733)5.27626451
15somatic hypermutation of immunoglobulin genes (GO:0016446)5.09308878
16somatic diversification of immune receptors via somatic mutation (GO:0002566)5.09308878
17mitochondrial DNA metabolic process (GO:0032042)5.05054314
18embryonic placenta development (GO:0001892)4.94990674
19cellular response to ATP (GO:0071318)4.93856355
20embryonic skeletal joint morphogenesis (GO:0060272)4.89477034
21poly(A)+ mRNA export from nucleus (GO:0016973)4.78564957
22mitotic G1 DNA damage checkpoint (GO:0031571)4.61277115
23negative regulation of JAK-STAT cascade (GO:0046426)4.56332998
24prostate epithelial cord arborization involved in prostate glandular acinus morphogenesis (GO:0060524.53196484
25organ induction (GO:0001759)4.47314787
26DNA integration (GO:0015074)4.44114323
27negative regulation of cell cycle arrest (GO:0071157)4.38536423
28planar cell polarity pathway involved in neural tube closure (GO:0090179)4.35273614
29peripheral nervous system neuron development (GO:0048935)4.27862511
30convergent extension (GO:0060026)4.24958420
31embryonic camera-type eye development (GO:0031076)4.24070043
32mRNA cleavage (GO:0006379)4.13604479
33Golgi transport vesicle coating (GO:0048200)4.13506101
34COPI coating of Golgi vesicle (GO:0048205)4.13506101
35glial cell migration (GO:0008347)4.05703681
36mitotic G1/S transition checkpoint (GO:0044819)4.04272123
37G1 DNA damage checkpoint (GO:0044783)4.03966010
38metanephric mesenchyme development (GO:0072075)4.02466691
39regulation of translational fidelity (GO:0006450)4.01179572
40kidney mesenchyme development (GO:0072074)4.00542445
41regulation of establishment of planar polarity involved in neural tube closure (GO:0090178)3.99371527
42glutamine family amino acid biosynthetic process (GO:0009084)3.94028595
43negative regulation of Ras GTPase activity (GO:0034261)3.90530861
44positive regulation of protein oligomerization (GO:0032461)3.88800310
45positive regulation of developmental pigmentation (GO:0048087)3.87451341
46face development (GO:0060324)3.86799671
47negative regulation of protein oligomerization (GO:0032460)3.84306361
48proximal/distal pattern formation (GO:0009954)3.80040964
49protein retention in ER lumen (GO:0006621)3.79885194
50embryonic skeletal system morphogenesis (GO:0048704)3.71260971
51maintenance of protein localization in endoplasmic reticulum (GO:0035437)3.68703568
52negative regulation of endoplasmic reticulum calcium ion concentration (GO:0032471)3.66617973
53apoptotic process involved in morphogenesis (GO:0060561)3.65942394
54cochlea morphogenesis (GO:0090103)3.64682343
55regulation of protein oligomerization (GO:0032459)3.63917887
56formation of translation preinitiation complex (GO:0001731)3.63386283
57regulation of branching involved in prostate gland morphogenesis (GO:0060687)3.62609377
58DNA topological change (GO:0006265)3.61781148
59cranial nerve morphogenesis (GO:0021602)3.60542628
60base-excision repair (GO:0006284)3.59746453
61spliceosomal tri-snRNP complex assembly (GO:0000244)3.58706395
62regulation of water loss via skin (GO:0033561)3.58408939
63histone H4-K12 acetylation (GO:0043983)3.58209521
64basement membrane organization (GO:0071711)3.53428886
65viral mRNA export from host cell nucleus (GO:0046784)3.53174762
66establishment of protein localization to mitochondrial membrane (GO:0090151)3.48540378
67mitochondrial RNA metabolic process (GO:0000959)3.45093901
68anatomical structure regression (GO:0060033)3.44956766
69muscle cell fate commitment (GO:0042693)3.44693894
70telomere maintenance via semi-conservative replication (GO:0032201)3.40168477
71regulation of double-strand break repair (GO:2000779)3.39128989
72trophectodermal cell differentiation (GO:0001829)3.36561280
73cellular response to zinc ion (GO:0071294)3.36319032
74negative regulation of catenin import into nucleus (GO:0035414)3.36186202
75positive regulation by host of viral transcription (GO:0043923)3.36070374
76regulation of gene silencing by RNA (GO:0060966)3.35591610
77regulation of posttranscriptional gene silencing (GO:0060147)3.35591610
78regulation of gene silencing by miRNA (GO:0060964)3.35591610
79negative regulation of chondrocyte differentiation (GO:0032331)3.34593486
80outflow tract septum morphogenesis (GO:0003148)3.34286660
81activation of Rac GTPase activity (GO:0032863)3.33010018
82nodal signaling pathway (GO:0038092)3.32291710
83kinetochore assembly (GO:0051382)3.31832238
84embryonic forelimb morphogenesis (GO:0035115)3.31694426
85negative regulation of fatty acid biosynthetic process (GO:0045717)3.29673703
86biotin metabolic process (GO:0006768)3.29395302
87regulation of cardioblast proliferation (GO:0003264)3.29248849
88regulation of secondary heart field cardioblast proliferation (GO:0003266)3.29248849
89myoblast migration (GO:0051451)3.26800021
90DNA double-strand break processing (GO:0000729)3.25944845
91negative regulation of myoblast differentiation (GO:0045662)3.25071231
92base-excision repair, AP site formation (GO:0006285)3.24959447
93regulation of double-strand break repair via homologous recombination (GO:0010569)3.23469146
94forelimb morphogenesis (GO:0035136)3.22334349
95spinal cord development (GO:0021510)3.20945669
96retrograde vesicle-mediated transport, Golgi to ER (GO:0006890)3.19236700
97branching involved in prostate gland morphogenesis (GO:0060442)3.19154022
98GDP-mannose metabolic process (GO:0019673)3.19058513
99regulation of epithelial cell proliferation involved in prostate gland development (GO:0060768)3.18998731
100desmosome organization (GO:0002934)3.16546493
101semaphorin-plexin signaling pathway (GO:0071526)3.16442614
102negative regulation of mRNA splicing, via spliceosome (GO:0048025)3.14585875
103neuron fate specification (GO:0048665)3.14296805
104negative regulation of adherens junction organization (GO:1903392)3.13797521
105negative regulation of focal adhesion assembly (GO:0051895)3.13797521
106negative regulation of cell junction assembly (GO:1901889)3.13797521
107non-recombinational repair (GO:0000726)3.13425483
108double-strand break repair via nonhomologous end joining (GO:0006303)3.13425483
109regulation of RNA export from nucleus (GO:0046831)3.12538425
110DNA synthesis involved in DNA repair (GO:0000731)3.11527173
111bone morphogenesis (GO:0060349)3.11407318
112establishment of skin barrier (GO:0061436)3.10355593
113nucleotide-excision repair, DNA gap filling (GO:0006297)3.08184863
114adherens junction assembly (GO:0034333)3.07676050
115negative regulation of cell size (GO:0045792)3.07246173
116negative regulation of cartilage development (GO:0061037)3.07096817
117apoptotic process involved in development (GO:1902742)3.06207396
118regulation of cardioblast differentiation (GO:0051890)3.06165386
119maturation of 5.8S rRNA (GO:0000460)3.05600554
120pyrimidine deoxyribonucleotide catabolic process (GO:0009223)3.04424470
121regulation of heart morphogenesis (GO:2000826)3.04330981
122negative regulation of heart rate (GO:0010459)3.03677140
123regulation of fatty acid beta-oxidation (GO:0031998)3.02595612
124iron ion import (GO:0097286)3.01933145
125segment specification (GO:0007379)3.01834778
126meiotic chromosome segregation (GO:0045132)3.00025051
127protein heterotrimerization (GO:0070208)2.99861951
128negative regulation of tumor necrosis factor production (GO:0032720)2.99732242
129sulfur amino acid catabolic process (GO:0000098)2.98263790
130regulation of cell size (GO:0008361)2.97597881
131regulation of hippo signaling (GO:0035330)2.96618563
132anterior/posterior axis specification, embryo (GO:0008595)2.95139364
133generation of neurons (GO:0048699)2.92619057
134positive regulation of DNA repair (GO:0045739)2.91983481
135regulation of podosome assembly (GO:0071801)2.91951374
136positive regulation of receptor recycling (GO:0001921)2.91519391
137hematopoietic stem cell proliferation (GO:0071425)2.90821232
138nuclear envelope reassembly (GO:0031468)2.89120819
139mitotic nuclear envelope reassembly (GO:0007084)2.89120819
140positive regulation of metaphase/anaphase transition of cell cycle (GO:1902101)2.88843863
141positive regulation of mitotic sister chromatid separation (GO:1901970)2.88843863
142regulation of organ formation (GO:0003156)2.85603997
143skeletal system morphogenesis (GO:0048705)2.83563764
144embryonic cranial skeleton morphogenesis (GO:0048701)2.82367732
145embryonic organ morphogenesis (GO:0048562)2.81640939
146synaptonemal complex assembly (GO:0007130)2.78535385
147lymph vessel development (GO:0001945)2.78480326
148maternal placenta development (GO:0001893)2.74958779
149negative regulation of glucose import (GO:0046325)2.74569025
150vascular endothelial growth factor signaling pathway (GO:0038084)2.73852764
151regulation of mitotic spindle organization (GO:0060236)2.72970468
152thyroid gland development (GO:0030878)2.71542572
153Wnt signaling pathway, planar cell polarity pathway (GO:0060071)2.70254275
154pharyngeal system development (GO:0060037)2.70105301
155cell-substrate adherens junction assembly (GO:0007045)2.69782618
156focal adhesion assembly (GO:0048041)2.69782618
157endothelial cell chemotaxis (GO:0035767)2.68931151
158mammary gland epithelial cell differentiation (GO:0060644)2.68503368
159positive regulation of myoblast differentiation (GO:0045663)2.66667592
160insulin-like growth factor receptor signaling pathway (GO:0048009)2.63780887
161L-serine metabolic process (GO:0006563)2.63089060
162mesenchyme morphogenesis (GO:0072132)2.61706048
163regulation of mammary gland epithelial cell proliferation (GO:0033599)2.60714358
164striated muscle cell proliferation (GO:0014855)2.59197272
165regulation of establishment of planar polarity (GO:0090175)2.55575584
166vascular endothelial growth factor receptor signaling pathway (GO:0048010)2.54169350
167intracellular estrogen receptor signaling pathway (GO:0030520)2.52628851
168snRNA metabolic process (GO:0016073)2.51145318
169mammary gland development (GO:0030879)2.50814841
170regulation of glucose import in response to insulin stimulus (GO:2001273)2.50707063
171aorta morphogenesis (GO:0035909)2.50242144
172cardiac muscle cell proliferation (GO:0060038)2.50006420
173developmental induction (GO:0031128)2.49918315
174embryonic digit morphogenesis (GO:0042733)2.49620579
175metanephros development (GO:0001656)2.49189558
176middle ear morphogenesis (GO:0042474)2.49044327
177anterior/posterior pattern specification (GO:0009952)2.48353755
178negative regulation of embryonic development (GO:0045992)2.46853508
179muscle cell migration (GO:0014812)2.43885769
180anatomical structure arrangement (GO:0048532)2.43122042
181positive regulation of transcription from RNA polymerase III promoter (GO:0045945)2.42093926
182nuclear pore complex assembly (GO:0051292)2.40581471
183positive regulation of histone deacetylation (GO:0031065)2.40472450
184regulation of transforming growth factor beta2 production (GO:0032909)2.40257551
185embryonic limb morphogenesis (GO:0030326)2.39717688
186embryonic appendage morphogenesis (GO:0035113)2.39717688
187response to testosterone (GO:0033574)2.39048392
188stress granule assembly (GO:0034063)2.38911806
189synaptonemal complex organization (GO:0070193)2.37699859
190muscle cell proliferation (GO:0033002)2.37534192
191facial nerve structural organization (GO:0021612)2.35079165
192cell-cell signaling involved in cell fate commitment (GO:0045168)2.34019133
193proline biosynthetic process (GO:0006561)10.1359049

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1KLF2_18264089_ChIP-ChIP_MESCs_Mouse4.14111750
2KLF5_18264089_ChIP-ChIP_MESCs_Mouse4.14111750
3KLF4_18264089_ChIP-ChIP_MESCs_Mouse4.14111750
4* ZFP281_18358816_ChIP-ChIP_MESCs_Mouse3.51993923
5SMAD1_18555785_ChIP-Seq_MESCs_Mouse3.44584661
6SMAD3_22036565_ChIP-Seq_ESCs_Mouse3.19009791
7RUNX1_26923725_Chip-Seq_MACROPHAGESS_Mouse3.13902385
8TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat2.90427947
9SOX2_18358816_ChIP-ChIP_MESCs_Mouse2.84287366
10NANOG_18700969_ChIP-ChIP_MESCs_Mouse2.81383612
11NACC1_18358816_ChIP-ChIP_MESCs_Mouse2.80619092
12MYBL1_21750041_ChIP-ChIP_SPERMATOCYTES_Mouse2.68060341
13RARG_19884340_ChIP-ChIP_MEFs_Mouse2.54747659
14* KLF4_18358816_ChIP-ChIP_MESCs_Mouse2.42173786
15POU5F1_16518401_ChIP-PET_MESCs_Mouse2.41107210
16* TCF3_18692474_ChIP-Seq_MESCs_Mouse2.34911107
17ESR2_21235772_ChIP-Seq_MCF-7_Human2.27350603
18PPARG_19300518_ChIP-PET_3T3-L1_Mouse2.20623943
19AR_21909140_ChIP-Seq_LNCAP_Human2.16910482
20ZNF652_21678463_ChIP-ChIP_ZR75-1_Human2.14041062
21EZH2_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse2.13598452
22* TCF3_18692474_ChIP-Seq_MEFs_Mouse2.09126739
23DACH1_20351289_ChIP-Seq_MDA-MB-231_Human2.07738012
24STAT3_1855785_ChIP-Seq_MESCs_Mouse2.05320828
25* NR0B1_18358816_ChIP-ChIP_MESCs_Mouse2.03643232
26LXR_22292898_ChIP-Seq_THP-1_Human2.02924163
27MYC_18555785_ChIP-Seq_MESCs_Mouse2.02540346
28VDR_21846776_ChIP-Seq_THP-1_Human1.99787439
29POU5F1_18700969_ChIP-ChIP_MESCs_Mouse1.96495648
30ZNF263_19887448_ChIP-Seq_K562_Human1.96020720
31HCFC1_20581084_ChIP-Seq_MESCs_Mouse1.92675965
32ESR1_20079471_ChIP-ChIP_T-47D_Human1.92402648
33XRN2_22483619_ChIP-Seq_HELA_Human1.92307638
34* SALL4_18804426_ChIP-ChIP_MESCs_Mouse1.91954109
35STAT6_21828071_ChIP-Seq_BEAS2B_Human1.89782670
36ERG_21242973_ChIP-ChIP_JURKAT_Human1.87996698
37TRIM28_21343339_ChIP-Seq_HEK293_Human1.87425688
38* EZH2_27304074_Chip-Seq_ESCs_Mouse1.84589702
39CTNNB1_24651522_ChIP-Seq_LGR5+_INTESTINAL_STEM_Human1.84492832
40ZIC3_20872845_ChIP-ChIP_MESCs_Mouse1.84072450
41CHD1_26751641_Chip-Seq_LNCaP_Human1.84009471
42* ZFP281_18757296_ChIP-ChIP_E14_Mouse1.83555732
43MYC_19079543_ChIP-ChIP_MESCs_Mouse1.81036019
44THRA_23701648_ChIP-Seq_CEREBELLUM_Mouse1.78654850
45CHD7_19251738_ChIP-ChIP_MESCs_Mouse1.72219461
46TFAP2C_20629094_ChIP-Seq_MCF-7_Human1.70372226
47KDM5A_27292631_Chip-Seq_BREAST_Human1.66398372
48TP63_17297297_ChIP-ChIP_HaCaT_Human1.65736528
49EKLF_21900194_ChIP-Seq_ERYTHROCYTE_Mouse1.65226474
50* ZFP281_27345836_Chip-Seq_ESCs_Mouse1.64905345
51* NANOG_18347094_ChIP-ChIP_MESCs_Mouse1.64089477
52CREB1_26743006_Chip-Seq_LNCaP_Human1.61773942
53NANOG_18358816_ChIP-ChIP_MESCs_Mouse1.61243067
54CREB1_23762244_ChIP-Seq_HIPPOCAMPUS_Rat1.61234210
55TAF7L_23326641_ChIP-Seq_C3H10T1-2_Mouse1.60031337
56* TET1_21451524_ChIP-Seq_MESCs_Mouse1.56760796
57ZFX_18555785_ChIP-Seq_MESCs_Mouse1.56738090
58MYC_18358816_ChIP-ChIP_MESCs_Mouse1.56572721
59* CBX2_27304074_Chip-Seq_ESCs_Mouse1.55461027
60ATF3_27146783_Chip-Seq_COLON_Human1.54595496
61* RACK7_27058665_Chip-Seq_MCF-7_Human1.54253153
62ESR1_15608294_ChIP-ChIP_MCF-7_Human1.52745541
63NANOG_21062744_ChIP-ChIP_HESCs_Human1.52369306
64KLF6_26769127_Chip-Seq_PDAC-Cell_line_Human1.51549050
65* UBF1/2_26484160_Chip-Seq_HMEC-DERIVED_Human1.51055254
66HOXD13_18407260_ChIP-ChIP_DEVELOPING-LIMBS_Mouse1.50677041
67PPARD_23176727_ChIP-Seq_KERATINOCYTES_Mouse1.49004077
68KDM2B_26808549_Chip-Seq_SUP-B15_Human1.48641100
69* EED_16625203_ChIP-ChIP_MESCs_Mouse1.47353140
70PKCTHETA_26484144_Chip-Seq_BREAST_Human1.46941093
71PU.1_20513432_ChIP-Seq_Bcells_Mouse1.46208400
72CREB1_26743006_Chip-Seq_LNCaP-abl_Human1.45953786
73RUNX1_27514584_Chip-Seq_MCF-7_Human1.40368081
74FOXM1_23109430_ChIP-Seq_U2OS_Human1.40313358
75RCOR2_21632747_ChIP-Seq_MESCs_Mouse1.40003599
76* POU5F1_18692474_ChIP-Seq_MESCs_Mouse1.38824853
77WT1_20215353_ChIP-ChIP_NEPHRON_PROGENITOR_Mouse1.38717793
78P68_20966046_ChIP-Seq_HELA_Human1.37779173
79POU5F1_18358816_ChIP-ChIP_MESCs_Mouse1.36445881
80MYC_22102868_ChIP-Seq_BL_Human1.36077981
81NANOG_18692474_ChIP-Seq_MESCs_Mouse1.35474598
82* PHC1_16625203_ChIP-ChIP_MESCs_Mouse1.35371733
83DCP1A_22483619_ChIP-Seq_HELA_Human1.33631617
84NANOG_18555785_ChIP-Seq_MESCs_Mouse1.32766027
85UBF1/2_26484160_Chip-Seq_HMECs_Human1.32473825
86CTNNB1_20615089_ChIP-ChIP_FETAL_BRAIN_Human1.31999736
87SOX2_18692474_ChIP-Seq_MESCs_Mouse1.31834078
88* TP53_20018659_ChIP-ChIP_R1E_Mouse1.31493758
89PRDM14_21183938_ChIP-Seq_MESCs_Mouse1.31394133
90ELK3_25401928_ChIP-Seq_HUVEC_Human1.31037012
91TCFAP2C_20176728_ChIP-ChIP_TROPHOBLAST_STEM_CELLS_Mouse1.30988674
92CDX2_20551321_ChIP-Seq_CACO-2_Human1.30304924
93RXRA_24833708_ChIP-Seq_LIVER_Mouse1.30021089
94TP63_19390658_ChIP-ChIP_HaCaT_Human1.28657464
95PU.1_20513432_ChIP-Seq_MACROPHAGES_Mouse1.28469041
96KLF4_18555785_ChIP-Seq_MESCs_Mouse1.26706869
97EGR1_20690147_ChIP-Seq_ERYTHROLEUKEMIA_Human1.25546610
98SOX2_18692474_ChIP-Seq_MEFs_Mouse1.25083030
99SALL1_21062744_ChIP-ChIP_HESCs_Human1.23394038
100* RNF2_18974828_ChIP-Seq_MESCs_Mouse1.22565730
101* EZH2_18974828_ChIP-Seq_MESCs_Mouse1.22565730
102* STAT3_19079543_ChIP-ChIP_MESCs_Mouse1.22432277
103MYC_19030024_ChIP-ChIP_MESCs_Mouse1.21895329
104ESR1_21235772_ChIP-Seq_MCF-7_Human1.20621766
105KLF4_26769127_Chip-Seq_PDAC-Cell_line_Human1.19671283
106SPI1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.19537990
107* RUNX2_24764292_ChIP-Seq_MC3T3_Mouse1.19180808
108KDM2B_26808549_Chip-Seq_DND41_Human1.18728511
109RARB_24833708_ChIP-Seq_LIVER_Mouse1.18540948
110* TCF3_18347094_ChIP-ChIP_MESCs_Mouse1.18356921
111CLOCK_20551151_ChIP-Seq_293T_Human1.18054235
112SOX2_18555785_ChIP-Seq_MESCs_Mouse1.16490261
113KDM2B_26808549_Chip-Seq_SIL-ALL_Human1.16404167
114TBP_23326641_ChIP-Seq_C3H10T1-2_Mouse1.16377683
115CTCF_21964334_ChIP-Seq_BJAB-B_Human1.16128740
116MYCN_27167114_Chip-Seq_NEUROBLASTOMA_Human1.15893488
117SPI1_26923725_Chip-Seq_HPCs_Mouse1.15465630
118NANOG_16518401_ChIP-PET_MESCs_Mouse1.15445320
119THAP11_20581084_ChIP-Seq_MESCs_Mouse1.14688276
120* JARID2_20075857_ChIP-Seq_MESCs_Mouse1.14084413
121SREBP1_19666523_ChIP-Seq_LIVER_Mouse1.14054647
122NKX2-5_21415370_ChIP-Seq_HL-1_Mouse1.13436247
123HIF1A_21447827_ChIP-Seq_MCF-7_Human1.13414306
124P300_27058665_Chip-Seq_ZR-75-30cells_Human1.13102062
125ETS1_21867929_ChIP-Seq_TH2_Mouse1.12341604
126FOXM1_25889361_ChIP-Seq_OE33_AND_U2OS_Human1.12260970
127* OCT4_18692474_ChIP-Seq_MEFs_Mouse1.10865414
128KDM2B_26808549_Chip-Seq_HPB-ALL_Human1.10384587
129NELFA_20434984_ChIP-Seq_ESCs_Mouse1.10272995
130* SETDB1_19884255_ChIP-Seq_MESCs_Mouse1.09741736
131SREBP2_21459322_ChIP-Seq_LIVER_Mouse1.09685255
132TBX5_21415370_ChIP-Seq_HL-1_Mouse1.09180673
133SRY_22984422_ChIP-ChIP_TESTIS_Rat1.09108793
134RARA_24833708_ChIP-Seq_LIVER_Mouse1.09104460
135TP53_23651856_ChIP-Seq_MEFs_Mouse1.08158914
136CTCF_27219007_Chip-Seq_ERYTHROID_Human1.08057578
137YY1_21170310_ChIP-Seq_MESCs_Mouse1.08054652
138CTCF_27219007_Chip-Seq_Bcells_Human1.07739911
139NUCKS1_24931609_ChIP-Seq_HEPATOCYTES_Mouse1.07248645
140TP53_22127205_ChIP-Seq_IMR90_Human1.06396548
141MYCN_18555785_ChIP-Seq_MESCs_Mouse1.05962735
142PRDM5_23873026_ChIP-Seq_MEFs_Mouse1.05780884
143* KDM2B_26808549_Chip-Seq_K562_Human1.05274962
144SA1_27219007_Chip-Seq_ERYTHROID_Human1.04309404
145* KLF4_19030024_ChIP-ChIP_MESCs_Mouse1.03167715
146CCND1_20090754_ChIP-ChIP_RETINA_Mouse1.02452726
147SOX9_25088423_ChIP-ChIP_EMBRYONIC_GONADS_Mouse1.01867862
148KAP1_27257070_Chip-Seq_ESCs_Mouse1.01675704
149YY1_22570637_ChIP-Seq_MALME-3M_Human1.00988724
150* RING1B_27294783_Chip-Seq_NPCs_Mouse1.00752818
151E2F1_18555785_ChIP-Seq_MESCs_Mouse0.99770898
152TRP63_18441228_ChIP-ChIP_KERATINOCYTES_Mouse0.98213188
153SMC4_20622854_ChIP-Seq_HELA_Human0.97696942
154NR1H3_23393188_ChIP-Seq_ATHEROSCLEROTIC-FOAM_Human0.97563196
155NANOG_18692474_ChIP-Seq_MEFs_Mouse0.97523327
156E2F7_22180533_ChIP-Seq_HELA_Human0.95570053
157CREB1_20920259_ChIP-Seq_GC1-SPG_Mouse0.95330475
158RCOR3_21632747_ChIP-Seq_MESCs_Mouse0.94711492

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0005171_absent_coat_pigmentation5.33285274
2MP0008057_abnormal_DNA_replication4.93773395
3MP0010030_abnormal_orbit_morphology4.69185888
4MP0009278_abnormal_bone_marrow3.83937139
5MP0003283_abnormal_digestive_organ3.53654211
6MP0004233_abnormal_muscle_weight3.42327414
7MP0004858_abnormal_nervous_system3.17405364
8MP0001346_abnormal_lacrimal_gland3.09437637
9MP0000733_abnormal_muscle_development2.72527850
10MP0008438_abnormal_cutaneous_collagen2.54996444
11MP0003705_abnormal_hypodermis_morpholog2.51414769
12MP0004133_heterotaxia2.37320178
13MP0002249_abnormal_larynx_morphology2.21056983
14MP0002282_abnormal_trachea_morphology2.05830626
15MP0002009_preneoplasia1.94708811
16MP0003890_abnormal_embryonic-extraembry1.94637882
17MP0005076_abnormal_cell_differentiation1.86414916
18MP0003786_premature_aging1.86252718
19MP0003123_paternal_imprinting1.85217740
20MP0000579_abnormal_nail_morphology1.83063912
21MP0008995_early_reproductive_senescence1.82083588
22MP0000566_synostosis1.79602766
23MP0010352_gastrointestinal_tract_polyps1.78821291
24MP0000751_myopathy1.77223878
25MP0001661_extended_life_span1.74937457
26MP0002653_abnormal_ependyma_morphology1.73200479
27MP0001293_anophthalmia1.72939897
28MP0003119_abnormal_digestive_system1.68636325
29MP0004185_abnormal_adipocyte_glucose1.66769548
30MP0001545_abnormal_hematopoietic_system1.66225552
31MP0005397_hematopoietic_system_phenotyp1.66225552
32MP0000003_abnormal_adipose_tissue1.62774391
33MP0003279_aneurysm1.61537429
34MP0003453_abnormal_keratinocyte_physiol1.61241002
35MP0005508_abnormal_skeleton_morphology1.59064155
36MP0002877_abnormal_melanocyte_morpholog1.57182832
37MP0009780_abnormal_chondrocyte_physiolo1.56813610
38MP0010094_abnormal_chromosome_stability1.54247783
39MP0004957_abnormal_blastocyst_morpholog1.50424676
40MP0002098_abnormal_vibrissa_morphology1.49115543
41MP0002932_abnormal_joint_morphology1.49044904
42MP0002084_abnormal_developmental_patter1.47820105
43MP0000537_abnormal_urethra_morphology1.47074269
44MP0000762_abnormal_tongue_morphology1.43919610
45MP0002111_abnormal_tail_morphology1.43391422
46MP0000759_abnormal_skeletal_muscle1.41709378
47MP0002060_abnormal_skin_morphology1.41595997
48MP0000750_abnormal_muscle_regeneration1.39331795
49MP0002085_abnormal_embryonic_tissue1.38501135
50MP0001188_hyperpigmentation1.38290562
51MP0005023_abnormal_wound_healing1.38125930
52MP0002086_abnormal_extraembryonic_tissu1.37298299
53MP0005409_darkened_coat_color1.35647310
54MP0005623_abnormal_meninges_morphology1.35605705
55MP0002160_abnormal_reproductive_system1.35056441
56MP0005666_abnormal_adipose_tissue1.34616822
57MP0003385_abnormal_body_wall1.33855937
58MP0003755_abnormal_palate_morphology1.33367042
59MP0008932_abnormal_embryonic_tissue1.32870511
60MP0006072_abnormal_retinal_apoptosis1.32723689
61MP0009250_abnormal_appendicular_skeleto1.32669855
62MP0004197_abnormal_fetal_growth/weight/1.31734263
63MP0000534_abnormal_ureter_morphology1.30395681
64MP0000490_abnormal_crypts_of1.30112305
65MP0001879_abnormal_lymphatic_vessel1.27923300
66MP0005375_adipose_tissue_phenotype1.27786462
67MP0004272_abnormal_basement_membrane1.25385631
68MP0002114_abnormal_axial_skeleton1.23671063
69MP0005174_abnormal_tail_pigmentation1.22433394
70MP0001340_abnormal_eyelid_morphology1.20794581
71MP0000678_abnormal_parathyroid_gland1.16753942
72MP0001697_abnormal_embryo_size1.16712645
73MP0000377_abnormal_hair_follicle1.16403040
74MP0004142_abnormal_muscle_tone1.16337340
75MP0004381_abnormal_hair_follicle1.14938757
76MP0009053_abnormal_anal_canal1.14105414
77MP0003111_abnormal_nucleus_morphology1.12980181
78MP0002269_muscular_atrophy1.12609503
79MP0002116_abnormal_craniofacial_bone1.11416740
80MP0003935_abnormal_craniofacial_develop1.09317939
81MP0000462_abnormal_digestive_system1.08035347
82MP0005330_cardiomyopathy1.07566197
83MP0000639_abnormal_adrenal_gland1.07438463
84MP0003172_abnormal_lysosome_physiology1.07146405
85MP0000467_abnormal_esophagus_morphology1.07090017
86MP0010234_abnormal_vibrissa_follicle1.05658640
87MP0005075_abnormal_melanosome_morpholog1.05648821
88MP0005670_abnormal_white_adipose1.05006924
89MP0000470_abnormal_stomach_morphology1.04646927
90MP0001672_abnormal_embryogenesis/_devel1.04290490
91MP0005380_embryogenesis_phenotype1.04290490
92MP0002896_abnormal_bone_mineralization1.03994392
93MP0003045_fibrosis1.03978805
94MP0000432_abnormal_head_morphology1.03834011
95MP0002796_impaired_skin_barrier1.01394074
96MP0003566_abnormal_cell_adhesion1.01146962
97MP0008058_abnormal_DNA_repair1.00118185
98MP0005275_abnormal_skin_tensile0.98168560
99MP0000627_abnormal_mammary_gland0.97109080
100MP0003941_abnormal_skin_development0.96897394
101MP0005248_abnormal_Harderian_gland0.96593659
102MP0002332_abnormal_exercise_endurance0.96361858
103MP0002108_abnormal_muscle_morphology0.96248809
104MP0000613_abnormal_salivary_gland0.95901940
105MP0000371_diluted_coat_color0.95711376
106MP0002234_abnormal_pharynx_morphology0.95415078
107MP0004087_abnormal_muscle_fiber0.93687866
108MP0001216_abnormal_epidermal_layer0.92863156
109MP0000049_abnormal_middle_ear0.91927935
110MP0002295_abnormal_pulmonary_circulatio0.91384947
111MP0003115_abnormal_respiratory_system0.90486111
112MP0000350_abnormal_cell_proliferation0.89797160
113MP0010771_integument_phenotype0.87937998
114MP0004264_abnormal_extraembryonic_tissu0.85942148
115MP0009115_abnormal_fat_cell0.84902625
116MP0000647_abnormal_sebaceous_gland0.84862941
117MP0005058_abnormal_lysosome_morphology0.83634526
118MP0000427_abnormal_hair_cycle0.83505951
119MP0005451_abnormal_body_composition0.83282157
120MP0000015_abnormal_ear_pigmentation0.82754169
121MP0000383_abnormal_hair_follicle0.81972458
122MP0003950_abnormal_plasma_membrane0.81623889
123MP0003942_abnormal_urinary_system0.79681288
124MP0002075_abnormal_coat/hair_pigmentati0.79004765
125MP0005501_abnormal_skin_physiology0.78958518
126MP0001270_distended_abdomen0.78655917
127MP0005085_abnormal_gallbladder_physiolo0.78258304
128MP0002080_prenatal_lethality0.77919146
129MP0010630_abnormal_cardiac_muscle0.77748100
130MP0000747_muscle_weakness0.77685589
131MP0001958_emphysema0.76663419
132MP0003828_pulmonary_edema0.76279511
133MP0005647_abnormal_sex_gland0.75634029
134MP0001299_abnormal_eye_distance/0.74988154
135MP0005645_abnormal_hypothalamus_physiol0.74755560
136MP0010307_abnormal_tumor_latency0.74458500
137MP0009931_abnormal_skin_appearance0.74373754
138MP0002092_abnormal_eye_morphology0.74108799
139MP0003984_embryonic_growth_retardation0.73919078
140MP0002697_abnormal_eye_size0.73824799
141MP0002938_white_spotting0.73270868
142MP0008007_abnormal_cellular_replicative0.73026867
143MP0003077_abnormal_cell_cycle0.72816249
144MP0006082_CNS_inflammation0.72639388
145MP0005266_abnormal_metabolism0.70690712
146MP0001881_abnormal_mammary_gland0.70625433
147MP0002088_abnormal_embryonic_growth/wei0.70358848
148MP0001730_embryonic_growth_arrest0.70198353
149MP0003315_abnormal_perineum_morphology0.70132674
150MP0005503_abnormal_tendon_morphology0.70086769
151MP0002970_abnormal_white_adipose0.69413013
152MP0001243_abnormal_dermal_layer0.69289169
153MP0005257_abnormal_intraocular_pressure0.69248449
154MP0005367_renal/urinary_system_phenotyp0.68118046
155MP0000516_abnormal_urinary_system0.68118046
156MP0003567_abnormal_fetal_cardiomyocyte0.68018214
157MP0000767_abnormal_smooth_muscle0.67304995
158MP0002113_abnormal_skeleton_development0.67090263

Predicted human phenotypes

RankGene SetZ-score
1Rib fusion (HP:0000902)6.24276959
2Ulnar bowing (HP:0003031)4.99940007
3Concave nail (HP:0001598)4.93772853
4Turricephaly (HP:0000262)4.82237938
5Sparse lateral eyebrow (HP:0005338)4.73402725
6Facial hemangioma (HP:0000329)4.72562114
7Rectovaginal fistula (HP:0000143)4.65703669
8Rectal fistula (HP:0100590)4.65703669
9Coronal craniosynostosis (HP:0004440)4.50716932
10Lip pit (HP:0100267)4.42662601
11Pustule (HP:0200039)4.21060966
12Intestinal fistula (HP:0100819)4.19774878
13Annular pancreas (HP:0001734)4.13468542
14Alopecia of scalp (HP:0002293)4.09010005
15Increased IgM level (HP:0003496)4.08625067
16Vaginal fistula (HP:0004320)4.08337668
17Protrusio acetabuli (HP:0003179)3.92552260
18Short humerus (HP:0005792)3.62256034
19Shallow orbits (HP:0000586)3.53615428
20Poikiloderma (HP:0001029)3.53488593
21Hypochromic microcytic anemia (HP:0004840)3.48482336
22Aplasia/hypoplasia of the humerus (HP:0006507)3.47293760
23Tongue fasciculations (HP:0001308)3.46178231
24Testicular atrophy (HP:0000029)3.42187953
25Cerebral aneurysm (HP:0004944)3.35856075
26Infantile muscular hypotonia (HP:0008947)3.25221876
27Muscle fibrillation (HP:0010546)3.24522370
28Broad distal phalanx of finger (HP:0009836)3.12054863
29Calcaneovalgus deformity (HP:0001848)3.12027466
30Aplasia/Hypoplasia involving the carpal bones (HP:0006502)3.11340419
31Abnormal hemoglobin (HP:0011902)3.10863648
32Abnormality of the phalanges of the hallux (HP:0010057)3.02953901
33Squamous cell carcinoma (HP:0002860)3.02556660
34Aplasia/Hypoplasia of the vertebrae (HP:0008515)2.99375859
35Vertebral hypoplasia (HP:0008417)2.99375859
36Joint stiffness (HP:0001387)2.96752259
37Congenital hip dislocation (HP:0001374)2.89374886
38Narrow nasal bridge (HP:0000446)2.86968331
39Premature rupture of membranes (HP:0001788)2.83834428
40Abnormality of the distal phalanges of the toes (HP:0010182)2.83276310
41Bowed forearm bones (HP:0003956)2.82462029
42Bowing of the arm (HP:0006488)2.82462029
43Alacrima (HP:0000522)2.81376842
44Abnormality of the distal phalanx of the thumb (HP:0009617)2.78058678
45Orthostatic hypotension (HP:0001278)2.77449267
46Abnormality of male internal genitalia (HP:0000022)2.71556452
47Mucopolysacchariduria (HP:0008155)2.70852368
48Urinary glycosaminoglycan excretion (HP:0003541)2.70852368
49Preauricular pit (HP:0004467)2.70719340
50Periauricular skin pits (HP:0100277)2.70719340
51Absent radius (HP:0003974)2.69048792
52Abnormality of the aortic arch (HP:0012303)2.63185897
53Deformed tarsal bones (HP:0008119)2.62317273
54Short 5th finger (HP:0009237)2.61963506
55Short chin (HP:0000331)2.61781859
56Anteriorly placed anus (HP:0001545)2.61607591
57Abnormality of the calcaneus (HP:0008364)2.60095373
58Male infertility (HP:0003251)2.59604822
59Selective tooth agenesis (HP:0001592)2.56157770
60Obstructive sleep apnea (HP:0002870)2.56095111
61Intestinal atresia (HP:0011100)2.54836901
62Skin pits (HP:0100276)2.53056364
63Dysostosis multiplex (HP:0000943)2.52805647
64Absent forearm bone (HP:0003953)2.50840085
65Aplasia involving forearm bones (HP:0009822)2.50840085
66Broad alveolar ridges (HP:0000187)2.49850014
67Abnormality of glycosaminoglycan metabolism (HP:0004371)2.43007411
68Abnormality of mucopolysaccharide metabolism (HP:0011020)2.43007411
69Abnormality of polysaccharide metabolism (HP:0011012)2.43007411
70Hyperacusis (HP:0010780)2.41202305
71Abnormality of the astrocytes (HP:0100707)2.40902359
72Astrocytoma (HP:0009592)2.40902359
73Capillary hemangiomas (HP:0005306)2.39736567
74Akinesia (HP:0002304)2.38612048
75Premature skin wrinkling (HP:0100678)2.38152622
76Double outlet right ventricle (HP:0001719)2.36749637
77Congenital malformation of the right heart (HP:0011723)2.36749637
78Hypotrichosis (HP:0001006)2.36168477
79Basal cell carcinoma (HP:0002671)2.35847594
80Aplasia/Hypoplasia of the 5th finger (HP:0006262)2.35729755
81Pterygium (HP:0001059)2.30745505
82Vertebral fusion (HP:0002948)2.29821961
83Acute lymphatic leukemia (HP:0006721)2.28319531
84Generalized amyotrophy (HP:0003700)2.28099816
85Aplasia of the musculature (HP:0100854)2.26926202
86Bulbar palsy (HP:0001283)2.26390960
87Abnormality of the umbilical cord (HP:0010881)2.26306412
88Dislocated radial head (HP:0003083)2.24135397
89Choanal stenosis (HP:0000452)2.23586307
90Abnormal ventriculo-arterial connection (HP:0011563)2.23422405
91Transposition of the great arteries (HP:0001669)2.23422405
92Abnormal connection of the cardiac segments (HP:0011545)2.23422405
93Premature graying of hair (HP:0002216)2.23365069
94Abnormality of the radial head (HP:0003995)2.18010659
95Hamartoma (HP:0010566)2.16632963
96Aortic dissection (HP:0002647)2.16339824
97Hypotelorism (HP:0000601)2.16040991
98Dysautonomia (HP:0002459)2.15967645
99Hypoplastic heart (HP:0001961)2.14235425
100Increased number of teeth (HP:0011069)2.13550371
101Vertebral compression fractures (HP:0002953)2.12888024
102Long toe (HP:0010511)2.12572194
103Bifid uvula (HP:0000193)2.11557220
104Diaphragmatic weakness (HP:0009113)2.10899887
105Pseudobulbar signs (HP:0002200)2.10759602
106Fragile skin (HP:0001030)2.10485604
107Pancreatic islet-cell hyperplasia (HP:0004510)2.10135060
108Thin ribs (HP:0000883)2.07488107
109Congenital glaucoma (HP:0001087)2.04520552
110Abnormal umbilical cord blood vessels (HP:0011403)2.02566007
111Single umbilical artery (HP:0001195)2.02566007
112Abnormality of the fetal cardiovascular system (HP:0010948)2.02566007
113Broad face (HP:0000283)2.02347289
114Absent thumb (HP:0009777)2.01906994
115Split hand (HP:0001171)2.01316249
116Bladder diverticulum (HP:0000015)2.01156198
117Cervical subluxation (HP:0003308)2.00966717
118Abnormality of the labia minora (HP:0012880)2.00869604
119Hypochromic anemia (HP:0001931)2.00406587
120Short 1st metacarpal (HP:0010034)1.99249762
121Aplasia/Hypoplasia of the 1st metacarpal (HP:0010026)1.99249762
122Increased variability in muscle fiber diameter (HP:0003557)1.99173912
123Advanced eruption of teeth (HP:0006288)1.98818480
124Overgrowth (HP:0001548)1.98430811
125Septate vagina (HP:0001153)1.97746744
126Mitral valve prolapse (HP:0001634)1.96842806
127Patellar aplasia (HP:0006443)1.96649763
128Large for gestational age (HP:0001520)1.96471410
129Clumsiness (HP:0002312)1.95933312
130Blue sclerae (HP:0000592)1.94047729
131Decreased lacrimation (HP:0000633)1.91585277
132Albinism (HP:0001022)1.90570254
133Abnormality of the lower motor neuron (HP:0002366)1.89633229
134Microretrognathia (HP:0000308)1.89472844
135Preaxial foot polydactyly (HP:0001841)1.85550363
136Germ cell neoplasia (HP:0100728)1.83869772
137Pili torti (HP:0003777)1.83089228
138Ankle contracture (HP:0006466)1.82813292
139Thin bony cortex (HP:0002753)1.82536072
140Long palpebral fissure (HP:0000637)1.82329094
141Broad toe (HP:0001837)1.81356440
142Hypokinesia (HP:0002375)1.81253311
143Spinal rigidity (HP:0003306)1.81237328
144IgA deficiency (HP:0002720)1.80616915
145Dysmetric saccades (HP:0000641)1.78626971
146Redundant skin (HP:0001582)1.78605629
147Aplasia/Hypoplasia of the patella (HP:0006498)1.78350078
148Gastrointestinal dysmotility (HP:0002579)1.77910320
149Acanthosis nigricans (HP:0000956)1.77889089
150Small hand (HP:0200055)1.77126334
151Elbow flexion contracture (HP:0002987)1.76551622
152Hypercortisolism (HP:0001578)1.76210215
153Cone-shaped epiphyses of the phalanges of the hand (HP:0010230)1.75963931
154Growth hormone excess (HP:0000845)1.75513985
155Popliteal pterygium (HP:0009756)1.75347206
156Abnormalities of placenta or umbilical cord (HP:0001194)1.74531168
157Short clavicles (HP:0000894)1.72162677
158Truncus arteriosus (HP:0001660)1.71641516
159Narrow palate (HP:0000189)1.70926009
160Natal tooth (HP:0000695)1.69848650
161Cholecystitis (HP:0001082)1.69761334
162Abnormal gallbladder physiology (HP:0012438)1.69761334
163Genu recurvatum (HP:0002816)1.67577321
164Slender long bone (HP:0003100)1.67441892
165Breast hypoplasia (HP:0003187)1.66586578
166Atresia of the external auditory canal (HP:0000413)1.65419750
167Trismus (HP:0000211)1.65338905
168Bell-shaped thorax (HP:0001591)1.63094948
169Hypoplastic left heart (HP:0004383)1.62538521
170Exostoses (HP:0100777)1.60195578
171Abnormality of skeletal muscle fiber size (HP:0012084)1.59125235
172Diminished movement (HP:0002374)1.59016117
173Distal upper limb amyotrophy (HP:0007149)1.57194566
174Upper limb amyotrophy (HP:0009129)1.57194566
175Hyperextensible skin (HP:0000974)1.57153217
176Glioma (HP:0009733)1.56860376
177Abnormality of the humeroradial joint (HP:0100744)1.56816965
178Precocious puberty (HP:0000826)1.56636255
179Broad metatarsal (HP:0001783)1.53719447
180Large eyes (HP:0001090)1.53499051
181Short nail (HP:0001799)1.53417456
182Renal dysplasia (HP:0000110)1.51868480

Predicted kinase interactions (KEA)

RankGene SetZ-score
1DDR25.58014502
2ICK5.54239615
3MAPK155.00312533
4PRKD34.24476642
5MAP3K63.92920783
6SMG13.72766537
7EEF2K3.16653079
8MAP3K112.98463131
9TYRO32.93147752
10MATK2.89343015
11PRKD22.73494699
12CASK2.59921764
13FGR2.53840068
14PDGFRA2.45625683
15PIM22.35123706
16PINK12.32429412
17BMX2.29873691
18LATS22.10812116
19CAMK1D2.03838292
20DAPK11.99712641
21CSK1.97567829
22IRAK31.95144126
23UHMK11.85928709
24PKN21.84500880
25STK38L1.82910108
26CAMK1G1.78567369
27DYRK1B1.77794334
28CDK71.76258744
29YES11.74124843
30TESK11.58184853
31TRPM71.57438411
32CDK121.54480477
33MYLK1.48172621
34TAF11.38832111
35AKT31.38722932
36PIM11.34946423
37DMPK1.33068728
38VRK21.24846640
39CDC42BPA1.21162298
40MET1.17968596
41FER1.15841954
42ILK1.13671938
43CDK61.11784543
44SCYL21.08929364
45MAPK111.06843570
46GSK3A1.06366133
47PRPF4B1.04396376
48PBK1.03124002
49CHEK21.02120157
50MAP3K31.00084760
51MUSK0.98140656
52MAP3K100.97136723
53PLK10.94382913
54EIF2AK10.93728700
55TAOK20.92265820
56BRD40.92099447
57RPS6KL10.87846042
58RPS6KC10.87846042
59KSR20.86288981
60STK240.85868660
61CDK90.81603504
62STK390.80637392
63MELK0.79869828
64ARAF0.79228559
65PRKCI0.77620149
66MTOR0.77391723
67EPHA20.77107210
68PHKG20.76920606
69PHKG10.76920606
70CSNK1A1L0.75916748
71RPS6KA60.74261984
72STK30.72893512
73TRIB30.72597857
74TTN0.69340499
75RET0.67787874
76MAP2K30.63704212
77NME20.63600936
78PNCK0.63434104
79DYRK30.62332256
80HIPK20.61058679
81BRSK10.60209802
82MAP3K20.59984676
83FGFR40.59136641
84PRKAA10.59040847
85WEE10.58452889
86MAP2K10.55463131
87PAK60.54759525
88TTK0.53547106
89PRKCH0.51800806
90ERN10.51025692
91RPS6KA20.50928635
92ERBB30.50324251
93NTRK10.50068625
94MAPKAPK30.49940467
95PTK20.49446378
96IRAK20.48106868
97RPS6KB20.47898204
98PDGFRB0.45418893
99CSNK1G10.45366024
100PAK20.45333231
101CDK80.45332346
102BRAF0.45069444
103MAPKAPK50.42458303
104LATS10.42109103
105SIK10.41980542
106ATR0.41507941
107RPS6KA10.41287012
108KSR10.40387570
109TESK20.40216375
110TAOK10.39816437
111MAPK10.39236074
112RIPK10.38964074
113MAPK40.36862319
114LIMK10.36514233
115CDK20.36387763
116TRIM280.35944569
117EGFR0.35573792
118FLT30.35543317
119CAMK2G0.35296747
120CDK40.35216611
121MAP3K120.35164395
122AURKA0.34857268
123INSR0.33945032
124CAMK2B0.33743982
125STK100.33682003
126BUB10.33599766
127CSNK2A10.32533301
128PDPK10.32341191
129MAP3K90.32047834
130MAPK30.31742810
131TNK20.31589122
132BRSK20.31459389
133MARK20.31076327
134CSNK1G30.30542389
135MAPK100.30133911
136EPHA30.29984108
137GRK50.28770599
138DYRK20.28037631
139EPHB10.27928960
140MKNK20.27601119
141FGFR10.27544419
142TSSK60.27312227
143PAK40.27213223
144LYN0.26953472
145ALK0.25063665
146PRKD10.24284430
147MAPK140.23960133
148MOS0.22258465
149CDK150.22057550
150PAK10.21223998
151AKT20.21101012
152RAF10.20896812
153GRK60.20692622
154STK380.20573054
155CSNK2A20.20150497
156CHEK10.19799573
157CDK11A0.19699009
158ATM0.19282262
159PRKAA20.19246686
160CDK10.18786820

Predicted pathways (KEGG)

RankGene SetZ-score
1Fatty acid biosynthesis_Homo sapiens_hsa000615.11610638
2Mismatch repair_Homo sapiens_hsa034304.49819330
3Base excision repair_Homo sapiens_hsa034104.48092842
4DNA replication_Homo sapiens_hsa030303.32954327
5Hedgehog signaling pathway_Homo sapiens_hsa043402.42676759
6Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005332.37894819
7Hippo signaling pathway_Homo sapiens_hsa043902.35473778
8Notch signaling pathway_Homo sapiens_hsa043302.31796292
9Nucleotide excision repair_Homo sapiens_hsa034202.14635892
10mTOR signaling pathway_Homo sapiens_hsa041502.11108124
11Arginine and proline metabolism_Homo sapiens_hsa003302.08241678
12Taurine and hypotaurine metabolism_Homo sapiens_hsa004302.06170034
13Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030082.05413980
14Phenylalanine metabolism_Homo sapiens_hsa003601.96836950
15Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001301.96609803
16Adherens junction_Homo sapiens_hsa045201.96064820
17p53 signaling pathway_Homo sapiens_hsa041151.91590917
18Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa005201.90949920
19Basal cell carcinoma_Homo sapiens_hsa052171.84421811
20Citrate cycle (TCA cycle)_Homo sapiens_hsa000201.82225971
21Bladder cancer_Homo sapiens_hsa052191.81345045
22Non-small cell lung cancer_Homo sapiens_hsa052231.58884701
23Wnt signaling pathway_Homo sapiens_hsa043101.58733886
24Fanconi anemia pathway_Homo sapiens_hsa034601.58592235
25Longevity regulating pathway - mammal_Homo sapiens_hsa042111.56857725
26Homologous recombination_Homo sapiens_hsa034401.56412321
27TGF-beta signaling pathway_Homo sapiens_hsa043501.56282746
28Circadian rhythm_Homo sapiens_hsa047101.47730205
29RNA transport_Homo sapiens_hsa030131.43288329
30mRNA surveillance pathway_Homo sapiens_hsa030151.42742342
31Cyanoamino acid metabolism_Homo sapiens_hsa004601.35347844
32Glioma_Homo sapiens_hsa052141.33243325
33Shigellosis_Homo sapiens_hsa051311.32283944
34Cell cycle_Homo sapiens_hsa041101.32219639
35Transcriptional misregulation in cancer_Homo sapiens_hsa052021.31421339
36Spliceosome_Homo sapiens_hsa030401.28039443
37Biosynthesis of amino acids_Homo sapiens_hsa012301.27947469
38Sulfur relay system_Homo sapiens_hsa041221.25150577
39Other types of O-glycan biosynthesis_Homo sapiens_hsa005141.22791448
40Regulation of lipolysis in adipocytes_Homo sapiens_hsa049231.21225945
41Glycosaminoglycan degradation_Homo sapiens_hsa005311.17148677
42Regulation of actin cytoskeleton_Homo sapiens_hsa048101.16726127
43Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa045501.16080361
44Protein processing in endoplasmic reticulum_Homo sapiens_hsa041411.15055905
45Pentose phosphate pathway_Homo sapiens_hsa000301.14603181
46Vibrio cholerae infection_Homo sapiens_hsa051101.14583320
472-Oxocarboxylic acid metabolism_Homo sapiens_hsa012101.14460780
48Fatty acid elongation_Homo sapiens_hsa000621.13597985
49Fructose and mannose metabolism_Homo sapiens_hsa000511.13475192
50Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006031.10446024
51Renal cell carcinoma_Homo sapiens_hsa052111.09929924
52Lysine degradation_Homo sapiens_hsa003101.09548838
53Folate biosynthesis_Homo sapiens_hsa007901.09397853
54Fatty acid metabolism_Homo sapiens_hsa012121.08540228
55Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate_Homo sapiens_hsa005321.08241340
56MicroRNAs in cancer_Homo sapiens_hsa052061.05877641
57Thyroid hormone signaling pathway_Homo sapiens_hsa049191.03894976
58Pentose and glucuronate interconversions_Homo sapiens_hsa000400.99654704
59VEGF signaling pathway_Homo sapiens_hsa043700.98488271
60Vasopressin-regulated water reabsorption_Homo sapiens_hsa049620.98386626
61Vitamin digestion and absorption_Homo sapiens_hsa049770.98289980
62Vitamin B6 metabolism_Homo sapiens_hsa007500.96066807
63Prion diseases_Homo sapiens_hsa050200.95142841
64Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010400.94043232
65N-Glycan biosynthesis_Homo sapiens_hsa005100.92384257
66Oocyte meiosis_Homo sapiens_hsa041140.91628449
67Tight junction_Homo sapiens_hsa045300.91440100
68Bacterial invasion of epithelial cells_Homo sapiens_hsa051000.89133756
69Carbon metabolism_Homo sapiens_hsa012000.89052584
70Pyruvate metabolism_Homo sapiens_hsa006200.88716489
71Steroid biosynthesis_Homo sapiens_hsa001000.85421849
72Colorectal cancer_Homo sapiens_hsa052100.85190695
73Sphingolipid metabolism_Homo sapiens_hsa006000.84514998
74Proteoglycans in cancer_Homo sapiens_hsa052050.83957783
75Galactose metabolism_Homo sapiens_hsa000520.82718610
76Other glycan degradation_Homo sapiens_hsa005110.82608771
77One carbon pool by folate_Homo sapiens_hsa006700.81189728
78Gap junction_Homo sapiens_hsa045400.79583976
79Butirosin and neomycin biosynthesis_Homo sapiens_hsa005240.79524269
80Focal adhesion_Homo sapiens_hsa045100.77094503
81Axon guidance_Homo sapiens_hsa043600.76990543
82Progesterone-mediated oocyte maturation_Homo sapiens_hsa049140.76793539
83Glutathione metabolism_Homo sapiens_hsa004800.73672471
84Choline metabolism in cancer_Homo sapiens_hsa052310.73338045
85ErbB signaling pathway_Homo sapiens_hsa040120.73201246
86Small cell lung cancer_Homo sapiens_hsa052220.68993139
87Chronic myeloid leukemia_Homo sapiens_hsa052200.68769730
88Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa049610.68572669
89Neurotrophin signaling pathway_Homo sapiens_hsa047220.68377430
90PI3K-Akt signaling pathway_Homo sapiens_hsa041510.66093812
91AMPK signaling pathway_Homo sapiens_hsa041520.65984982
92Viral carcinogenesis_Homo sapiens_hsa052030.65610442
93Inositol phosphate metabolism_Homo sapiens_hsa005620.63194922
94Tyrosine metabolism_Homo sapiens_hsa003500.61423238
95Prolactin signaling pathway_Homo sapiens_hsa049170.59942162
96Melanogenesis_Homo sapiens_hsa049160.59623415
97Pathways in cancer_Homo sapiens_hsa052000.59356058
98Phosphatidylinositol signaling system_Homo sapiens_hsa040700.57328219
99Vascular smooth muscle contraction_Homo sapiens_hsa042700.55648848
100Glycine, serine and threonine metabolism_Homo sapiens_hsa002600.55090522
101Estrogen signaling pathway_Homo sapiens_hsa049150.54613860
102Arginine biosynthesis_Homo sapiens_hsa002200.51848561
103Viral myocarditis_Homo sapiens_hsa054160.51387172
104Acute myeloid leukemia_Homo sapiens_hsa052210.51358972
105Thyroid cancer_Homo sapiens_hsa052160.51322498
106Ubiquitin mediated proteolysis_Homo sapiens_hsa041200.49720944
107HTLV-I infection_Homo sapiens_hsa051660.49354624
108Central carbon metabolism in cancer_Homo sapiens_hsa052300.47705294
109Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007600.46705569
110Pyrimidine metabolism_Homo sapiens_hsa002400.44961777
111Primary bile acid biosynthesis_Homo sapiens_hsa001200.44159088
112Glucagon signaling pathway_Homo sapiens_hsa049220.44043941
113Sphingolipid signaling pathway_Homo sapiens_hsa040710.43938029
114Endocytosis_Homo sapiens_hsa041440.43058505
115Maturity onset diabetes of the young_Homo sapiens_hsa049500.42612426
116Rap1 signaling pathway_Homo sapiens_hsa040150.41172907
117Insulin resistance_Homo sapiens_hsa049310.41109002
118Dorso-ventral axis formation_Homo sapiens_hsa043200.40678711
119Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005630.39538588
120Melanoma_Homo sapiens_hsa052180.38297737
121Primary immunodeficiency_Homo sapiens_hsa053400.36635067
122Insulin signaling pathway_Homo sapiens_hsa049100.33529364
123MAPK signaling pathway_Homo sapiens_hsa040100.33223064
124Prostate cancer_Homo sapiens_hsa052150.32903138
125Fc gamma R-mediated phagocytosis_Homo sapiens_hsa046660.30677093
126ECM-receptor interaction_Homo sapiens_hsa045120.30600201
127Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006040.29322665
128Pancreatic cancer_Homo sapiens_hsa052120.28306766
129Endometrial cancer_Homo sapiens_hsa052130.23325550
130GnRH signaling pathway_Homo sapiens_hsa049120.22834517
131Fc epsilon RI signaling pathway_Homo sapiens_hsa046640.22061905
132AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa049330.21517254
133Legionellosis_Homo sapiens_hsa051340.20267653
134Arachidonic acid metabolism_Homo sapiens_hsa005900.19949359
135Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002500.19925334
136HIF-1 signaling pathway_Homo sapiens_hsa040660.17362779
137Ras signaling pathway_Homo sapiens_hsa040140.16942324
138Longevity regulating pathway - multiple species_Homo sapiens_hsa042130.16897116
139Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa009700.16103120
140Basal transcription factors_Homo sapiens_hsa030220.14555638
141Lysosome_Homo sapiens_hsa041420.14081696

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