HOXC13

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: This gene belongs to the homeobox family of genes. The homeobox genes encode a highly conserved family of transcription factors that play an important role in morphogenesis in all multicellular organisms. Mammals possess four similar homeobox gene clusters, HOXA, HOXB, HOXC and HOXD, which are located on different chromosomes and consist of 9 to 11 genes arranged in tandem. This gene is one of several homeobox HOXC genes located in a cluster on chromosome 12. The product of this gene may play a role in the development of hair, nail, and filiform papilla. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1transcription from mitochondrial promoter (GO:0006390)8.51135763
2proline metabolic process (GO:0006560)8.18424666
3embryonic process involved in female pregnancy (GO:0060136)7.95060880
4replication fork processing (GO:0031297)7.61110140
5positive regulation of protein homooligomerization (GO:0032464)6.94904996
6establishment of apical/basal cell polarity (GO:0035089)6.67162100
7regulation of integrin activation (GO:0033623)6.54641524
8oxidative demethylation (GO:0070989)6.26651063
9DNA deamination (GO:0045006)6.18456507
10maintenance of fidelity involved in DNA-dependent DNA replication (GO:0045005)6.10326449
11regulation of protein homooligomerization (GO:0032462)5.94577377
12establishment or maintenance of monopolar cell polarity (GO:0061339)5.79183161
13establishment of monopolar cell polarity (GO:0061162)5.79183161
14desmosome organization (GO:0002934)5.39913203
15mitochondrial DNA metabolic process (GO:0032042)5.38264798
16DNA strand renaturation (GO:0000733)5.23114484
17poly(A)+ mRNA export from nucleus (GO:0016973)5.15137585
18somatic diversification of immune receptors via somatic mutation (GO:0002566)5.14048799
19somatic hypermutation of immunoglobulin genes (GO:0016446)5.14048799
20embryonic placenta development (GO:0001892)4.94793712
21negative regulation of JAK-STAT cascade (GO:0046426)4.92193305
22mitotic G1 DNA damage checkpoint (GO:0031571)4.84475348
23regulation of branching involved in prostate gland morphogenesis (GO:0060687)4.83057494
24cellular response to ATP (GO:0071318)4.76911297
25regulation of mammary gland epithelial cell proliferation (GO:0033599)4.61315189
26negative regulation of cell cycle arrest (GO:0071157)4.60216420
27viral mRNA export from host cell nucleus (GO:0046784)4.54364077
28COPI coating of Golgi vesicle (GO:0048205)4.54163293
29Golgi transport vesicle coating (GO:0048200)4.54163293
30negative regulation of Ras GTPase activity (GO:0034261)4.49954211
31G1 DNA damage checkpoint (GO:0044783)4.36913886
32embryonic camera-type eye development (GO:0031076)4.31179051
33positive regulation of keratinocyte differentiation (GO:0045618)4.30254205
34mitotic G1/S transition checkpoint (GO:0044819)4.29742635
35glutamine family amino acid biosynthetic process (GO:0009084)4.29613962
36regulation of translational fidelity (GO:0006450)4.26139501
37mRNA cleavage (GO:0006379)4.24407935
38positive regulation of developmental pigmentation (GO:0048087)4.22959763
39DNA integration (GO:0015074)4.17518443
40establishment of protein localization to mitochondrial membrane (GO:0090151)4.12272749
41negative regulation of fatty acid biosynthetic process (GO:0045717)4.09672949
42convergent extension (GO:0060026)4.09599295
43positive regulation of protein oligomerization (GO:0032461)4.08842602
44face development (GO:0060324)4.07436092
45cellular response to zinc ion (GO:0071294)4.02349724
46negative regulation of protein oligomerization (GO:0032460)3.99737873
47spliceosomal tri-snRNP complex assembly (GO:0000244)3.97485278
48glial cell migration (GO:0008347)3.97019495
49formation of translation preinitiation complex (GO:0001731)3.96350481
50negative regulation of endoplasmic reticulum calcium ion concentration (GO:0032471)3.90730383
51regulation of water loss via skin (GO:0033561)3.89327070
52embryonic skeletal joint morphogenesis (GO:0060272)3.87416900
53epithelial cell maturation (GO:0002070)3.86762545
54histone H4-K12 acetylation (GO:0043983)3.86330773
55positive regulation by host of viral transcription (GO:0043923)3.86006474
56anatomical structure regression (GO:0060033)3.83075106
57regulation of protein oligomerization (GO:0032459)3.82154578
58base-excision repair (GO:0006284)3.79484485
59apoptotic process involved in morphogenesis (GO:0060561)3.75244313
60negative regulation of mRNA splicing, via spliceosome (GO:0048025)3.74303781
61trophectodermal cell differentiation (GO:0001829)3.73403833
62hemidesmosome assembly (GO:0031581)3.68628413
63mitotic chromosome condensation (GO:0007076)3.67994299
64positive regulation of mitotic sister chromatid separation (GO:1901970)3.57193698
65positive regulation of mitotic metaphase/anaphase transition (GO:0045842)3.57193698
66positive regulation of metaphase/anaphase transition of cell cycle (GO:1902101)3.57193698
67intestinal epithelial cell development (GO:0060576)3.55218490
68non-recombinational repair (GO:0000726)3.54504124
69double-strand break repair via nonhomologous end joining (GO:0006303)3.54504124
70DNA double-strand break processing (GO:0000729)3.53805932
71dosage compensation (GO:0007549)3.52519869
72base-excision repair, AP site formation (GO:0006285)3.49560588
73regulation of cell proliferation involved in kidney development (GO:1901722)3.48504544
74branching involved in mammary gland duct morphogenesis (GO:0060444)3.46667770
75regulation of RNA export from nucleus (GO:0046831)3.46359205
76regulation of sister chromatid cohesion (GO:0007063)3.45668493
77mitochondrial RNA metabolic process (GO:0000959)3.44893034
78labyrinthine layer development (GO:0060711)3.44186322
79positive regulation of epidermal cell differentiation (GO:0045606)3.44126450
80GDP-mannose metabolic process (GO:0019673)3.42421274
81negative regulation of mRNA processing (GO:0050686)3.37752610
82regulation of cAMP-dependent protein kinase activity (GO:2000479)3.33615892
83epithelial cell differentiation involved in prostate gland development (GO:0060742)3.33376453
84telomere maintenance via semi-conservative replication (GO:0032201)3.32522048
85positive regulation of DNA repair (GO:0045739)3.31516017
86DNA topological change (GO:0006265)3.29889388
87meiotic chromosome segregation (GO:0045132)3.28730395
88mammary gland epithelial cell differentiation (GO:0060644)3.28284884
89DNA demethylation (GO:0080111)3.28281607
90pyrimidine deoxyribonucleotide catabolic process (GO:0009223)3.27309170
91hypotonic response (GO:0006971)3.25422277
92negative regulation of chondrocyte differentiation (GO:0032331)3.25419260
93nodal signaling pathway (GO:0038092)3.25026009
94maternal placenta development (GO:0001893)3.24371221
95negative regulation of heart rate (GO:0010459)3.24152897
96regulation of double-strand break repair (GO:2000779)3.24144217
97regulation of double-strand break repair via homologous recombination (GO:0010569)3.23135425
98signal complex assembly (GO:0007172)3.20960406
99nucleotide-excision repair, DNA gap filling (GO:0006297)3.20866361
100regulation of posttranscriptional gene silencing (GO:0060147)3.20740263
101regulation of gene silencing by miRNA (GO:0060964)3.20740263
102regulation of gene silencing by RNA (GO:0060966)3.20740263
103protein targeting to vacuole (GO:0006623)3.20397132
104protein targeting to lysosome (GO:0006622)3.20397132
105establishment of protein localization to vacuole (GO:0072666)3.20397132
106establishment of skin barrier (GO:0061436)3.19006598
107activation of Rac GTPase activity (GO:0032863)3.18517879
108bundle of His cell to Purkinje myocyte communication (GO:0086069)3.18015137
109negative regulation of cell size (GO:0045792)3.17120530
110DNA ligation (GO:0006266)3.16314474
111positive regulation of epidermis development (GO:0045684)3.15932040
112regulation of cell size (GO:0008361)3.15628485
113retinoic acid receptor signaling pathway (GO:0048384)3.15216671
114termination of RNA polymerase II transcription (GO:0006369)3.14968822
115peptidyl-arginine omega-N-methylation (GO:0035247)3.14093712
116outflow tract septum morphogenesis (GO:0003148)3.13369473
117nuclear envelope reassembly (GO:0031468)3.11434529
118mitotic nuclear envelope reassembly (GO:0007084)3.11434529
119ear development (GO:0043583)3.11094569
120sulfur amino acid catabolic process (GO:0000098)3.09180577
121auditory receptor cell stereocilium organization (GO:0060088)3.08719608
122regulation of podosome assembly (GO:0071801)3.08605796
123negative regulation of response to food (GO:0032096)3.07145190
124negative regulation of appetite (GO:0032099)3.07145190
125protein complex localization (GO:0031503)3.04198020
126retrograde vesicle-mediated transport, Golgi to ER (GO:0006890)3.01665916
127uterus development (GO:0060065)3.00300863
128prostate epithelial cord arborization involved in prostate glandular acinus morphogenesis (GO:0060522.99968695
129regulation of apoptotic process involved in morphogenesis (GO:1902337)2.96136964
130regulation of keratinocyte differentiation (GO:0045616)2.93752383
131protein localization to microtubule (GO:0035372)2.93094603
132ribosomal small subunit biogenesis (GO:0042274)2.92351562
133positive regulation of hair follicle development (GO:0051798)2.88323456
134positive regulation of hair cycle (GO:0042635)2.88323456
135adherens junction assembly (GO:0034333)2.88123823
136DNA unwinding involved in DNA replication (GO:0006268)2.85941541
137embryonic eye morphogenesis (GO:0048048)2.84018778
138regulation of histone H3-K27 methylation (GO:0061085)2.82918597
139nucleobase-containing small molecule interconversion (GO:0015949)2.80798696
140mitotic sister chromatid cohesion (GO:0007064)2.77939380
141cellular protein complex localization (GO:0034629)2.77838011
142nuclear pore complex assembly (GO:0051292)2.77470350
143regulation of chromatin binding (GO:0035561)2.75558833
144cell-substrate adherens junction assembly (GO:0007045)2.72747683
145focal adhesion assembly (GO:0048041)2.72747683
146positive regulation of Cdc42 GTPase activity (GO:0043089)2.72297107
147dichotomous subdivision of an epithelial terminal unit (GO:0060600)2.71747733
148regulation of cardioblast differentiation (GO:0051890)2.71731099
149epithelial cell-cell adhesion (GO:0090136)2.70106116
150cardiac right ventricle morphogenesis (GO:0003215)2.68552130
151hepatocyte apoptotic process (GO:0097284)2.67531397
152regulation of translational termination (GO:0006449)2.64364417
153mitotic sister chromatid segregation (GO:0000070)2.64040445
154response to food (GO:0032094)2.63066434
155ribosome biogenesis (GO:0042254)2.61811093
156regulation of attachment of spindle microtubules to kinetochore (GO:0051988)2.57315956
157folic acid metabolic process (GO:0046655)2.57098567
158regulation of fatty acid beta-oxidation (GO:0031998)2.56559259
159intracellular estrogen receptor signaling pathway (GO:0030520)2.56226416
160protein maturation by protein folding (GO:0022417)2.55082261
161cell-substrate junction assembly (GO:0007044)2.54904770
162mammary gland epithelial cell proliferation (GO:0033598)2.53480960
163mitotic metaphase plate congression (GO:0007080)2.53460683
164vagina development (GO:0060068)2.52423588
165peptidyl-arginine methylation (GO:0018216)2.52014073
166peptidyl-arginine N-methylation (GO:0035246)2.52014073
167cell differentiation involved in embryonic placenta development (GO:0060706)2.49875319
168mammary gland alveolus development (GO:0060749)2.48696516
169planar cell polarity pathway involved in neural tube closure (GO:0090179)2.48402588
170regulation of centriole replication (GO:0046599)2.46933894
171eyelid development in camera-type eye (GO:0061029)2.44575578
172proximal/distal pattern formation (GO:0009954)2.43815029
173maturation of SSU-rRNA (GO:0030490)2.43372423
174ribosome assembly (GO:0042255)2.41588024
175DNA strand elongation (GO:0022616)2.41310805
176protein localization to chromosome, centromeric region (GO:0071459)2.40666207
177negative regulation of keratinocyte proliferation (GO:0010839)2.40584940
178ribonucleoprotein complex biogenesis (GO:0022613)2.40077831
179maintenance of protein localization in endoplasmic reticulum (GO:0035437)2.39330387
180ER overload response (GO:0006983)2.38668997
181protein retention in ER lumen (GO:0006621)2.38006835
182biotin metabolic process (GO:0006768)2.37277816
183sister chromatid segregation (GO:0000819)2.35075831
184nuclear pore organization (GO:0006999)2.34628683
185histone arginine methylation (GO:0034969)2.33386825
186rRNA transcription (GO:0009303)2.32935011
187embryonic camera-type eye morphogenesis (GO:0048596)2.32483471
188proline biosynthetic process (GO:0006561)10.8626194

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1KLF5_18264089_ChIP-ChIP_MESCs_Mouse4.02987555
2KLF4_18264089_ChIP-ChIP_MESCs_Mouse4.02987555
3KLF2_18264089_ChIP-ChIP_MESCs_Mouse4.02987555
4SMAD1_18555785_ChIP-Seq_MESCs_Mouse3.67879864
5ZFP281_18358816_ChIP-ChIP_MESCs_Mouse3.58694585
6RUNX1_26923725_Chip-Seq_MACROPHAGESS_Mouse3.16718707
7SMAD3_22036565_ChIP-Seq_ESCs_Mouse3.09213369
8SOX2_18358816_ChIP-ChIP_MESCs_Mouse2.88204007
9TRP63_18441228_ChIP-ChIP_KERATINOCYTES_Mouse2.74278367
10NANOG_18700969_ChIP-ChIP_MESCs_Mouse2.72524921
11* ESR2_21235772_ChIP-Seq_MCF-7_Human2.70914085
12HCFC1_20581084_ChIP-Seq_MESCs_Mouse2.69380163
13ESR1_20079471_ChIP-ChIP_T-47D_Human2.65866905
14NACC1_18358816_ChIP-ChIP_MESCs_Mouse2.60494435
15CTNNB1_24651522_ChIP-Seq_LGR5+_INTESTINAL_STEM_Human2.56722082
16TP63_17297297_ChIP-ChIP_HaCaT_Human2.43979370
17* ESR1_21235772_ChIP-Seq_MCF-7_Human2.41902301
18POU5F1_16518401_ChIP-PET_MESCs_Mouse2.39325675
19TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat2.38297069
20TCF3_18692474_ChIP-Seq_MESCs_Mouse2.36538997
21KLF4_18358816_ChIP-ChIP_MESCs_Mouse2.34047967
22MYBL1_21750041_ChIP-ChIP_SPERMATOCYTES_Mouse2.28492469
23VDR_21846776_ChIP-Seq_THP-1_Human2.27777323
24* ESR1_15608294_ChIP-ChIP_MCF-7_Human2.23333296
25ERG_21242973_ChIP-ChIP_JURKAT_Human2.21035887
26LXR_22292898_ChIP-Seq_THP-1_Human2.15668289
27DACH1_20351289_ChIP-Seq_MDA-MB-231_Human2.13232572
28XRN2_22483619_ChIP-Seq_HELA_Human2.12852205
29SALL4_18804426_ChIP-ChIP_MESCs_Mouse2.09441852
30TCF3_18692474_ChIP-Seq_MEFs_Mouse2.06767387
31AR_21909140_ChIP-Seq_LNCAP_Human2.06401816
32MYC_18555785_ChIP-Seq_MESCs_Mouse2.05716207
33POU5F1_18700969_ChIP-ChIP_MESCs_Mouse2.00269635
34NR0B1_18358816_ChIP-ChIP_MESCs_Mouse1.98660527
35ZNF652_21678463_ChIP-ChIP_ZR75-1_Human1.96389883
36HIF1A_21447827_ChIP-Seq_MCF-7_Human1.91347556
37EZH2_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse1.89357590
38ZIC3_20872845_ChIP-ChIP_MESCs_Mouse1.88375102
39ZFX_18555785_ChIP-Seq_MESCs_Mouse1.86827705
40STAT3_1855785_ChIP-Seq_MESCs_Mouse1.84617455
41NANOG_18347094_ChIP-ChIP_MESCs_Mouse1.82620896
42MYC_19079543_ChIP-ChIP_MESCs_Mouse1.80184281
43KDM5A_27292631_Chip-Seq_BREAST_Human1.77225437
44DCP1A_22483619_ChIP-Seq_HELA_Human1.73468845
45NELFA_20434984_ChIP-Seq_ESCs_Mouse1.72282719
46NANOG_21062744_ChIP-ChIP_HESCs_Human1.71831417
47PU.1_20513432_ChIP-Seq_Bcells_Mouse1.69961617
48JARID1A_20064375_ChIP-Seq_MESCs_Mouse1.69881988
49CREB1_23762244_ChIP-Seq_HIPPOCAMPUS_Rat1.68363930
50ZFP281_18757296_ChIP-ChIP_E14_Mouse1.64982646
51RACK7_27058665_Chip-Seq_MCF-7_Human1.64758613
52RUNX1_27514584_Chip-Seq_MCF-7_Human1.62878904
53ZFP281_27345836_Chip-Seq_ESCs_Mouse1.62862934
54PPARG_19300518_ChIP-PET_3T3-L1_Mouse1.62054141
55KLF6_26769127_Chip-Seq_PDAC-Cell_line_Human1.61555767
56TFAP2C_20629094_ChIP-Seq_MCF-7_Human1.61312921
57* CREB1_26743006_Chip-Seq_LNCaP-abl_Human1.53595635
58MYC_18358816_ChIP-ChIP_MESCs_Mouse1.52991635
59E2F1_21310950_ChIP-Seq_MCF-7_Human1.52701407
60NANOG_18358816_ChIP-ChIP_MESCs_Mouse1.51933751
61ATF3_27146783_Chip-Seq_COLON_Human1.50132242
62TET1_21451524_ChIP-Seq_MESCs_Mouse1.49764997
63EKLF_21900194_ChIP-Seq_ERYTHROCYTE_Mouse1.47309800
64* MYCN_18555785_ChIP-Seq_MESCs_Mouse1.46145484
65* POU5F1_18692474_ChIP-Seq_MESCs_Mouse1.43447291
66CHD1_26751641_Chip-Seq_LNCaP_Human1.42940763
67NANOG_18555785_ChIP-Seq_MESCs_Mouse1.41646334
68* NANOG_18692474_ChIP-Seq_MESCs_Mouse1.40690773
69CREB1_15753290_ChIP-ChIP_HEK293T_Human1.40481783
70RCOR2_21632747_ChIP-Seq_MESCs_Mouse1.40413979
71PRDM14_21183938_ChIP-Seq_MESCs_Mouse1.40044045
72PKCTHETA_26484144_Chip-Seq_BREAST_Human1.39470868
73KDM2B_26808549_Chip-Seq_SUP-B15_Human1.38867099
74ZNF263_19887448_ChIP-Seq_K562_Human1.38359610
75STAT6_21828071_ChIP-Seq_BEAS2B_Human1.37623663
76POU5F1_18358816_ChIP-ChIP_MESCs_Mouse1.35896787
77PU.1_20513432_ChIP-Seq_MACROPHAGES_Mouse1.34102827
78TCFAP2C_20176728_ChIP-ChIP_TROPHOBLAST_STEM_CELLS_Mouse1.33179987
79GABP_19822575_ChIP-Seq_HepG2_Human1.32857589
80RARG_19884340_ChIP-ChIP_MEFs_Mouse1.31611400
81TTF2_22483619_ChIP-Seq_HELA_Human1.31582911
82MYC_22102868_ChIP-Seq_BL_Human1.30531623
83* KLF4_18555785_ChIP-Seq_MESCs_Mouse1.29606116
84ETS1_20019798_ChIP-Seq_JURKAT_Human1.28863259
85* RXRA_24833708_ChIP-Seq_LIVER_Mouse1.28834600
86* SOX2_18692474_ChIP-Seq_MESCs_Mouse1.28651579
87MYC_19030024_ChIP-ChIP_MESCs_Mouse1.28356246
88HSF1_23293686_ChIP-Seq_STHDH_STRIATAL_Mouse1.27889945
89KDM2B_26808549_Chip-Seq_DND41_Human1.26499924
90SMAD4_19686287_ChIP-ChIP_HaCaT_Human1.24883798
91TCF3_18347094_ChIP-ChIP_MESCs_Mouse1.24700448
92RARB_24833708_ChIP-Seq_LIVER_Mouse1.21270196
93ETS1_21867929_ChIP-Seq_TH2_Mouse1.21196820
94KDM2B_26808549_Chip-Seq_SIL-ALL_Human1.19974513
95TAF7L_23326641_ChIP-Seq_C3H10T1-2_Mouse1.19851852
96DMRT1_21621532_ChIP-ChIP_FETAL_Ovary1.19618159
97* SOX2_18692474_ChIP-Seq_MEFs_Mouse1.19341288
98FOXM1_23109430_ChIP-Seq_U2OS_Human1.18408717
99GATA3_24758297_ChIP-Seq_MCF-7_Human1.17676683
100SOX2_18555785_ChIP-Seq_MESCs_Mouse1.17662026
101KDM2B_26808549_Chip-Seq_HPB-ALL_Human1.17188243
102CTCF_21964334_ChIP-Seq_BJAB-B_Human1.16743156
103NANOG_16518401_ChIP-PET_MESCs_Mouse1.16015508
104* TP53_20018659_ChIP-ChIP_R1E_Mouse1.15846111
105SREBP2_21459322_ChIP-Seq_LIVER_Mouse1.15501592
106ELK3_25401928_ChIP-Seq_HUVEC_Human1.15334543
107SPI1_26923725_Chip-Seq_HPCs_Mouse1.15324138
108NOTCH1_17114293_ChIP-ChIP_T-ALL_Human1.14220577
109* SPI1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.13217919
110SMARCA4_20176728_ChIP-ChIP_TSCs_Mouse1.12179006
111P300_27058665_Chip-Seq_ZR-75-30cells_Human1.11820075
112BCL3_23251550_ChIP-Seq_MUSCLE_Mouse1.11637617
113CDX2_20551321_ChIP-Seq_CACO-2_Human1.11528557
114SETDB1_19884255_ChIP-Seq_MESCs_Mouse1.10945631
115* OCT4_18692474_ChIP-Seq_MEFs_Mouse1.10160008
116YY1_21170310_ChIP-Seq_MESCs_Mouse1.10024719
117* KLF4_19030024_ChIP-ChIP_MESCs_Mouse1.09447192
118CTCF_27219007_Chip-Seq_ERYTHROID_Human1.09112106
119CCND1_20090754_ChIP-ChIP_RETINA_Mouse1.08709322
120CREM_20920259_ChIP-Seq_GC1-SPG_Mouse1.08244364
121E2F4_17652178_ChIP-ChIP_JURKAT_Human1.06569106
122CREB1_26743006_Chip-Seq_LNCaP_Human1.06501675
123KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human1.06435695
124TBP_23326641_ChIP-Seq_C3H10T1-2_Mouse1.05802128
125PHF8_20622854_ChIP-Seq_HELA_Human1.05702771
126RCOR3_21632747_ChIP-Seq_MESCs_Mouse1.05559419
127EOMES_20176728_ChIP-ChIP_TSCs_Mouse1.05071310
128SALL1_21062744_ChIP-ChIP_HESCs_Human1.05067022
129SMAD2_18955504_ChIP-ChIP_HaCaT_Human1.04978368
130SMAD3_18955504_ChIP-ChIP_HaCaT_Human1.04978368
131CREB1_20920259_ChIP-Seq_GC1-SPG_Mouse1.04891464
132E2F4_21247883_ChIP-Seq_LYMPHOBLASTOID_Human1.04857992
133CLOCK_20551151_ChIP-Seq_293T_Human1.04840124
134PRDM5_23873026_ChIP-Seq_MEFs_Mouse1.04603598
135GATA6_25053715_ChIP-Seq_YYC3_Human1.04519957
136RARA_24833708_ChIP-Seq_LIVER_Mouse1.04475157
137* NANOG_18692474_ChIP-Seq_MEFs_Mouse1.03938598
138BCOR_27268052_Chip-Seq_Bcells_Human1.02346427
139E2F1_18555785_ChIP-Seq_MESCs_Mouse1.02162387
140* TFEB_21752829_ChIP-Seq_HELA_Human1.02154864
141STAT1_20625510_ChIP-Seq_HELA_Human1.01947605
142* SREBP1_19666523_ChIP-Seq_LIVER_Mouse1.01743167
143ZFP42_18358816_ChIP-ChIP_MESCs_Mouse1.01567611
144FOXM1_25889361_ChIP-Seq_OE33_AND_U2OS_Human1.00915583
145KLF4_26769127_Chip-Seq_PDAC-Cell_line_Human1.00545476
146YY1_22570637_ChIP-Seq_MALME-3M_Human1.00526738
147P68_20966046_ChIP-Seq_HELA_Human1.00422629
148KAP1_27257070_Chip-Seq_ESCs_Mouse0.99732193
149SRY_22984422_ChIP-ChIP_TESTIS_Rat0.99634237
150TP63_19390658_ChIP-ChIP_HaCaT_Human0.99465061
151UBF1/2_26484160_Chip-Seq_HMEC-DERIVED_Human0.98818941
152MYBL2_22936984_ChIP-ChIP_MESCs_Mouse0.97763989
153* KDM2B_26808549_Chip-Seq_K562_Human0.97677581
154THAP11_20581084_ChIP-Seq_MESCs_Mouse0.97226907
155TCFCP2L1_18555785_ChIP-Seq_MESCs_Mouse0.96997196
156CNOT3_19339689_ChIP-ChIP_MESCs_Mouse0.96848429
157ELF3_26769127_Chip-Seq_PDAC-Cell_line_Human0.96608323
158E2F7_22180533_ChIP-Seq_HELA_Human0.96450066
159POU5F1_18555785_ChIP-Seq_MESCs_Mouse0.95995069
160CEBPB_24764292_ChIP-Seq_MC3T3_Mouse0.95814241
161UBF1/2_26484160_Chip-Seq_HMECs_Human0.95448706
162NUCKS1_24931609_ChIP-Seq_HEPATOCYTES_Mouse0.95271169
163* E2F1_20622854_ChIP-Seq_HELA_Human0.95061102
164ELF5_23300383_ChIP-Seq_T47D_Human0.95060324

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0008057_abnormal_DNA_replication5.99553653
2MP0005171_absent_coat_pigmentation4.77945399
3MP0010030_abnormal_orbit_morphology4.32277079
4MP0009278_abnormal_bone_marrow4.21196358
5MP0010234_abnormal_vibrissa_follicle3.85361350
6MP0002009_preneoplasia3.76271290
7MP0004233_abnormal_muscle_weight3.23926986
8* MP0002098_abnormal_vibrissa_morphology2.72626073
9MP0003890_abnormal_embryonic-extraembry2.70031589
10MP0001346_abnormal_lacrimal_gland2.64998315
11* MP0000579_abnormal_nail_morphology2.56696983
12MP0003693_abnormal_embryo_hatching2.55382293
13MP0002796_impaired_skin_barrier2.46223979
14MP0008995_early_reproductive_senescence2.40381005
15MP0003283_abnormal_digestive_organ2.34575660
16MP0003453_abnormal_keratinocyte_physiol2.32892283
17MP0000537_abnormal_urethra_morphology2.32734952
18MP0002249_abnormal_larynx_morphology2.20932192
19MP0009780_abnormal_chondrocyte_physiolo2.13219712
20MP0002877_abnormal_melanocyte_morpholog2.13140926
21MP0002653_abnormal_ependyma_morphology2.12892359
22MP0004133_heterotaxia2.11936362
23MP0004381_abnormal_hair_follicle2.09441591
24MP0005623_abnormal_meninges_morphology2.00478719
25MP0006072_abnormal_retinal_apoptosis1.99524063
26MP0003119_abnormal_digestive_system1.98094360
27MP0010678_abnormal_skin_adnexa1.96854027
28MP0001545_abnormal_hematopoietic_system1.95746705
29MP0005397_hematopoietic_system_phenotyp1.95746705
30MP0002282_abnormal_trachea_morphology1.94615724
31MP0003786_premature_aging1.88434856
32MP0000678_abnormal_parathyroid_gland1.87757387
33MP0010094_abnormal_chromosome_stability1.86541656
34MP0005174_abnormal_tail_pigmentation1.85527109
35MP0000627_abnormal_mammary_gland1.85416128
36MP0000383_abnormal_hair_follicle1.84751247
37MP0004185_abnormal_adipocyte_glucose1.79678626
38MP0010352_gastrointestinal_tract_polyps1.76246506
39MP0000377_abnormal_hair_follicle1.76188490
40MP0005076_abnormal_cell_differentiation1.72251594
41MP0004782_abnormal_surfactant_physiolog1.70183178
42MP0001293_anophthalmia1.69931526
43MP0005075_abnormal_melanosome_morpholog1.66046739
44MP0004957_abnormal_blastocyst_morpholog1.64796199
45MP0001216_abnormal_epidermal_layer1.63253597
46MP0002084_abnormal_developmental_patter1.59478639
47MP0002086_abnormal_extraembryonic_tissu1.57845023
48MP0005501_abnormal_skin_physiology1.54455574
49MP0005409_darkened_coat_color1.49704727
50MP0004858_abnormal_nervous_system1.43345056
51MP0004197_abnormal_fetal_growth/weight/1.42619304
52MP0003705_abnormal_hypodermis_morpholog1.41226089
53MP0002085_abnormal_embryonic_tissue1.41120730
54MP0004264_abnormal_extraembryonic_tissu1.39926894
55MP0003942_abnormal_urinary_system1.39689095
56MP0002060_abnormal_skin_morphology1.39239404
57MP0005451_abnormal_body_composition1.37585939
58MP0000427_abnormal_hair_cycle1.36275442
59MP0001697_abnormal_embryo_size1.36268064
60MP0000566_synostosis1.35718869
61MP0002160_abnormal_reproductive_system1.35475033
62MP0001881_abnormal_mammary_gland1.34908138
63MP0003755_abnormal_palate_morphology1.31267596
64MP0008877_abnormal_DNA_methylation1.30135653
65MP0000371_diluted_coat_color1.30095412
66MP0000470_abnormal_stomach_morphology1.28450427
67MP0003123_paternal_imprinting1.26595861
68MP0003172_abnormal_lysosome_physiology1.26021873
69MP0008932_abnormal_embryonic_tissue1.25956503
70MP0000462_abnormal_digestive_system1.24136529
71MP0001849_ear_inflammation1.23837309
72MP0009672_abnormal_birth_weight1.22773469
73MP0000647_abnormal_sebaceous_gland1.21671746
74MP0003567_abnormal_fetal_cardiomyocyte1.21286260
75MP0002932_abnormal_joint_morphology1.20450788
76MP0003315_abnormal_perineum_morphology1.20359817
77MP0002269_muscular_atrophy1.20083228
78MP0000015_abnormal_ear_pigmentation1.17951768
79MP0001727_abnormal_embryo_implantation1.17804665
80MP0000490_abnormal_crypts_of1.17331178
81MP0002234_abnormal_pharynx_morphology1.16532306
82MP0005380_embryogenesis_phenotype1.16246333
83MP0001672_abnormal_embryogenesis/_devel1.16246333
84MP0010307_abnormal_tumor_latency1.15819972
85MP0003045_fibrosis1.14273345
86MP0000733_abnormal_muscle_development1.14100054
87MP0003941_abnormal_skin_development1.13951885
88MP0008058_abnormal_DNA_repair1.13359069
89MP0001919_abnormal_reproductive_system1.13208407
90MP0003828_pulmonary_edema1.12569202
91MP0003935_abnormal_craniofacial_develop1.11255328
92MP0000467_abnormal_esophagus_morphology1.10859867
93MP0001348_abnormal_lacrimal_gland1.10525443
94MP0000639_abnormal_adrenal_gland1.07766135
95MP0000534_abnormal_ureter_morphology1.07467134
96MP0003111_abnormal_nucleus_morphology1.04707316
97MP0000003_abnormal_adipose_tissue1.04312199
98MP0005058_abnormal_lysosome_morphology1.00648971
99* MP0001340_abnormal_eyelid_morphology1.00553116
100MP0005508_abnormal_skeleton_morphology0.99055112
101MP0009931_abnormal_skin_appearance0.98240331
102MP0000432_abnormal_head_morphology0.98163239
103MP0002332_abnormal_exercise_endurance0.97686622
104MP0001873_stomach_inflammation0.97553620
105MP0002116_abnormal_craniofacial_bone0.97078839
106MP0000350_abnormal_cell_proliferation0.95357131
107* MP0002111_abnormal_tail_morphology0.94989742
108MP0009053_abnormal_anal_canal0.94640139
109MP0008007_abnormal_cellular_replicative0.90075907
110MP0003566_abnormal_cell_adhesion0.89812299
111MP0003137_abnormal_impulse_conducting0.88616962
112MP0008260_abnormal_autophagy0.87871138
113MP0002075_abnormal_coat/hair_pigmentati0.87246875
114* MP0002114_abnormal_axial_skeleton0.86624324
115MP0005367_renal/urinary_system_phenotyp0.85406235
116MP0000516_abnormal_urinary_system0.85406235
117MP0009115_abnormal_fat_cell0.85176150
118MP0003984_embryonic_growth_retardation0.84924797
119MP0003385_abnormal_body_wall0.83951892
120MP0001324_abnormal_eye_pigmentation0.83549169
121MP0005266_abnormal_metabolism0.82626627
122MP0001730_embryonic_growth_arrest0.82005774
123MP0002088_abnormal_embryonic_growth/wei0.81300451
124MP0009250_abnormal_appendicular_skeleto0.80711368
125MP0002080_prenatal_lethality0.78250279
126MP0002019_abnormal_tumor_incidence0.77302746
127MP0003136_yellow_coat_color0.76791616
128MP0000681_abnormal_thyroid_gland0.76615751
129MP0000049_abnormal_middle_ear0.76242885
130MP0003077_abnormal_cell_cycle0.76120493
131MP0005023_abnormal_wound_healing0.75745896
132MP0001186_pigmentation_phenotype0.74807359
133MP0001243_abnormal_dermal_layer0.72866103
134MP0001661_extended_life_span0.72680296
135MP0003115_abnormal_respiratory_system0.72598141
136MP0002089_abnormal_postnatal_growth/wei0.71890152
137MP0000750_abnormal_muscle_regeneration0.71882925
138MP0005275_abnormal_skin_tensile0.71817401
139MP0005248_abnormal_Harderian_gland0.70904663
140* MP0000762_abnormal_tongue_morphology0.70292897
141MP0002697_abnormal_eye_size0.70130468
142MP0005389_reproductive_system_phenotype0.68969223
143MP0003191_abnormal_cellular_cholesterol0.68819058
144MP0002970_abnormal_white_adipose0.68734099
145* MP0000367_abnormal_coat/_hair0.68704919
146MP0005330_cardiomyopathy0.68066844
147MP0001784_abnormal_fluid_regulation0.67822402
148MP0003936_abnormal_reproductive_system0.65804035
149MP0002108_abnormal_muscle_morphology0.65588137
150MP0005085_abnormal_gallbladder_physiolo0.65435520
151MP0005645_abnormal_hypothalamus_physiol0.61955473
152MP0010771_integument_phenotype0.61477435

Predicted human phenotypes

RankGene SetZ-score
1Rib fusion (HP:0000902)5.98050965
2Septate vagina (HP:0001153)5.50181325
3Alopecia of scalp (HP:0002293)5.15027178
4Rectal fistula (HP:0100590)5.00720700
5Rectovaginal fistula (HP:0000143)5.00720700
6Annular pancreas (HP:0001734)4.93618327
7Pustule (HP:0200039)4.83540725
8Facial hemangioma (HP:0000329)4.80431158
9Hypochromic microcytic anemia (HP:0004840)4.68082354
10Increased IgM level (HP:0003496)4.67379639
11Turricephaly (HP:0000262)4.66323111
12Intestinal fistula (HP:0100819)4.50815881
13Vaginal fistula (HP:0004320)4.40660298
14Ulnar bowing (HP:0003031)4.33995018
15Coronal craniosynostosis (HP:0004440)4.21019495
16Sparse lateral eyebrow (HP:0005338)4.18104522
17Poikiloderma (HP:0001029)4.15889610
18Pili torti (HP:0003777)3.87629267
19Short humerus (HP:0005792)3.87432709
20Tongue fasciculations (HP:0001308)3.80243777
21Abnormal hemoglobin (HP:0011902)3.77970176
22Aplasia/hypoplasia of the humerus (HP:0006507)3.70524486
23Aplasia/Hypoplasia involving the carpal bones (HP:0006502)3.68973898
24Abnormality of the distal phalanges of the toes (HP:0010182)3.61371917
25Orthostatic hypotension (HP:0001278)3.51374440
26Muscle fibrillation (HP:0010546)3.50631790
27Lip pit (HP:0100267)3.47577175
28Male infertility (HP:0003251)3.46172390
29Intestinal atresia (HP:0011100)3.40522005
30Aplasia/Hypoplasia of the vertebrae (HP:0008515)3.38720559
31Vertebral hypoplasia (HP:0008417)3.38720559
32Abnormality of nail color (HP:0100643)3.34382349
33Alacrima (HP:0000522)3.34128257
34Right ventricular cardiomyopathy (HP:0011663)3.23451696
35Anteriorly placed anus (HP:0001545)3.23441281
36Asymmetry of the thorax (HP:0001555)3.22510646
37Abnormality of the umbilical cord (HP:0010881)3.17141829
38Absent radius (HP:0003974)3.17074042
39Abnormality of the aortic arch (HP:0012303)3.13990914
40Abnormality of male internal genitalia (HP:0000022)3.07247087
41Congenital hip dislocation (HP:0001374)3.03840933
42Aplasia involving forearm bones (HP:0009822)2.97927933
43Absent forearm bone (HP:0003953)2.97927933
44Squamous cell carcinoma (HP:0002860)2.96668992
45Short chin (HP:0000331)2.96188822
46Premature skin wrinkling (HP:0100678)2.95273028
47Broad alveolar ridges (HP:0000187)2.89582233
48Hamartoma (HP:0010566)2.89242798
49Mucopolysacchariduria (HP:0008155)2.82471392
50Urinary glycosaminoglycan excretion (HP:0003541)2.82471392
51Abnormal umbilical cord blood vessels (HP:0011403)2.80451436
52Single umbilical artery (HP:0001195)2.80451436
53Abnormality of the fetal cardiovascular system (HP:0010948)2.80451436
54Dysautonomia (HP:0002459)2.77107861
55Micronodular cirrhosis (HP:0001413)2.77026224
56Amelogenesis imperfecta (HP:0000705)2.73738332
57Large for gestational age (HP:0001520)2.72822609
58Diaphragmatic weakness (HP:0009113)2.70223038
59Volvulus (HP:0002580)2.69969551
60Aplasia/Hypoplasia of the sacrum (HP:0008517)2.67492651
61Onycholysis (HP:0001806)2.65523880
62Pancreatic islet-cell hyperplasia (HP:0004510)2.64384786
63Selective tooth agenesis (HP:0001592)2.63474745
64Trismus (HP:0000211)2.62628193
65Basal cell carcinoma (HP:0002671)2.62298447
66Aplasia cutis congenita (HP:0001057)2.62184947
67Aplasia of the musculature (HP:0100854)2.59379384
68Popliteal pterygium (HP:0009756)2.58981178
69Hyperparathyroidism (HP:0000843)2.58752260
70Progressive muscle weakness (HP:0003323)2.58250513
71Abnormal hair laboratory examination (HP:0003328)2.58140782
72Absent thumb (HP:0009777)2.58047680
73Albinism (HP:0001022)2.57149029
74Choanal stenosis (HP:0000452)2.56279095
75J-shaped sella turcica (HP:0002680)2.56261099
76Bifid uvula (HP:0000193)2.56180280
77Pterygium (HP:0001059)2.54708081
78Hyperacusis (HP:0010780)2.53881120
79Testicular atrophy (HP:0000029)2.53380672
80Decreased lacrimation (HP:0000633)2.52667754
81Abnormality of polysaccharide metabolism (HP:0011012)2.52237867
82Abnormality of glycosaminoglycan metabolism (HP:0004371)2.52237867
83Abnormality of mucopolysaccharide metabolism (HP:0011020)2.52237867
84Vertebral fusion (HP:0002948)2.51888706
85Microglossia (HP:0000171)2.50702747
86Cerebral aneurysm (HP:0004944)2.50410017
87Hypotelorism (HP:0000601)2.50256862
88Hypochromic anemia (HP:0001931)2.50082967
89Abnormality of the phalanges of the hallux (HP:0010057)2.47847902
90Growth hormone excess (HP:0000845)2.47772503
91Clumsiness (HP:0002312)2.47707291
92Joint stiffness (HP:0001387)2.45730400
93Chromosomal breakage induced by crosslinking agents (HP:0003221)2.45488843
94Dysostosis multiplex (HP:0000943)2.44513373
95Short nail (HP:0001799)2.41677223
96Fragile nails (HP:0001808)2.41398840
97Hypoparathyroidism (HP:0000829)2.41028899
98Broad distal phalanx of finger (HP:0009836)2.39047003
99* Hypotrichosis (HP:0001006)2.36836747
100Abnormalities of placenta or umbilical cord (HP:0001194)2.36459380
101Increased number of teeth (HP:0011069)2.36266439
102Deviation of the thumb (HP:0009603)2.36087595
103Bowed forearm bones (HP:0003956)2.36014840
104Bowing of the arm (HP:0006488)2.36014840
105Distal lower limb muscle weakness (HP:0009053)2.35987503
106Narrow nasal bridge (HP:0000446)2.33093959
107Sparse eyelashes (HP:0000653)2.32643752
108Proximal placement of thumb (HP:0009623)2.30245788
109Hypokinesia (HP:0002375)2.30242292
110Split hand (HP:0001171)2.29315525
111Patellar aplasia (HP:0006443)2.29013909
112Flat acetabular roof (HP:0003180)2.28874012
113Deep philtrum (HP:0002002)2.28463879
114Abnormality of the labia minora (HP:0012880)2.25432738
115Capillary hemangiomas (HP:0005306)2.24786420
116Chromsome breakage (HP:0040012)2.24206583
117Palmoplantar hyperkeratosis (HP:0000972)2.21520443
118Microretrognathia (HP:0000308)2.20521585
119Premature graying of hair (HP:0002216)2.19199178
120Unilateral renal agenesis (HP:0000122)2.18679367
121Gastrointestinal atresia (HP:0002589)2.17068640
122Short 5th finger (HP:0009237)2.15484245
123Advanced eruption of teeth (HP:0006288)2.15059130
124Abnormality of the distal phalanx of the thumb (HP:0009617)2.14429858
125Abnormality of the astrocytes (HP:0100707)2.14195227
126Astrocytoma (HP:0009592)2.14195227
127Short clavicles (HP:0000894)2.10993432
128Palmar hyperkeratosis (HP:0010765)2.10130235
129Germ cell neoplasia (HP:0100728)2.08340688
130Spinal cord compression (HP:0002176)2.08143053
131Polycythemia (HP:0001901)2.07869238
132Aplasia/Hypoplasia of the patella (HP:0006498)2.07379854
133Thin bony cortex (HP:0002753)2.05277397
134Bulbar palsy (HP:0001283)2.04383509
135Breast carcinoma (HP:0003002)2.04262068
136Abnormality of placental membranes (HP:0011409)2.03699267
137Amniotic constriction ring (HP:0009775)2.03699267
138IgA deficiency (HP:0002720)2.02575845
139Abdominal distention (HP:0003270)2.00752741
140Hypercortisolism (HP:0001578)1.98070266
141Milia (HP:0001056)1.97674545
142Generalized amyotrophy (HP:0003700)1.97390671
143Curly hair (HP:0002212)1.97291824
144Ridged nail (HP:0001807)1.96825994
145Cheilitis (HP:0100825)1.95427843
146Breast hypoplasia (HP:0003187)1.94942556
147Hypoplasia of the ulna (HP:0003022)1.94779170
148Redundant skin (HP:0001582)1.94582982
149Macroorchidism (HP:0000053)1.94300337
150Aplasia/Hypoplasia of the 5th finger (HP:0006262)1.94175939
151Broad face (HP:0000283)1.93852310
152Neoplasm of the oral cavity (HP:0100649)1.92503599
153Abnormality of the lower motor neuron (HP:0002366)1.92429684
154Abnormality of the parietal bone (HP:0002696)1.91271665
155Woolly hair (HP:0002224)1.90237827
156Spinal muscular atrophy (HP:0007269)1.87886493
157Congenital glaucoma (HP:0001087)1.87330080
158Achilles tendon contracture (HP:0001771)1.87274370
159Aplasia/Hypoplasia of the clavicles (HP:0006710)1.86455933
160Congenital ichthyosiform erythroderma (HP:0007431)1.86399334
161Cutaneous melanoma (HP:0012056)1.85668540
162Patellar dislocation (HP:0002999)1.83449374
163Termporal pattern (HP:0011008)1.82364409
164Insidious onset (HP:0003587)1.82364409
165Plantar hyperkeratosis (HP:0007556)1.79341617
166Long palpebral fissure (HP:0000637)1.79142236
167* Nail dystrophy (HP:0008404)1.79103415
168Elbow flexion contracture (HP:0002987)1.78031548
169Absent eyelashes (HP:0000561)1.77873261
170Spinal cord lesions (HP:0100561)1.74610571
171Syringomyelia (HP:0003396)1.74610571
172Absent frontal sinuses (HP:0002688)1.73781048
173Ragged-red muscle fibers (HP:0003200)1.72428601
174Vertebral compression fractures (HP:0002953)1.71144542
175Exostoses (HP:0100777)1.71142898
176Abnormality of the frontal sinuses (HP:0002687)1.70715882
177Ankyloglossia (HP:0010296)1.69867715
178Preauricular skin tag (HP:0000384)1.67718264
179Atresia of the external auditory canal (HP:0000413)1.66283694
180Short thumb (HP:0009778)1.65448061
181Buphthalmos (HP:0000557)1.65382493
182Fasciculations (HP:0002380)1.64747056
183Back pain (HP:0003418)1.63685843
184Natal tooth (HP:0000695)1.63612250
185Abnormality of the gastric mucosa (HP:0004295)1.62222763
186Deformed sella turcica (HP:0002681)1.61156089
187Increased nuchal translucency (HP:0010880)1.59650375
188Down-sloping shoulders (HP:0200021)1.56967025
189Long toe (HP:0010511)1.55784619
190Abnormality of the Achilles tendon (HP:0005109)1.55012828
191Abnormality of the salivary glands (HP:0010286)1.54328413

Predicted kinase interactions (KEA)

RankGene SetZ-score
1ICK6.00863293
2DDR25.25820864
3MAPK155.11588966
4MAP3K64.62587830
5MAP3K113.39536190
6TYRO33.26398337
7PINK13.14602635
8MATK3.13498633
9SIK13.12646139
10NME23.01176051
11FGR2.96942685
12SMG12.78516418
13PKN22.69460132
14IRAK32.61198387
15SCYL22.36822754
16UHMK12.35912008
17PIM22.35041833
18DAPK12.33881155
19BMX2.30654282
20PRKD22.28998244
21CSK2.19915782
22PDGFRA2.17588525
23MST1R2.16282447
24EEF2K2.15684819
25YES12.09818943
26EIF2AK12.05491273
27DYRK1B2.04968713
28MUSK1.91050114
29TESK11.87288886
30PAK41.80850479
31AKT31.76551416
32PBK1.71831325
33CDK71.71629802
34BUB11.70848939
35LATS21.67984152
36TRPM71.61920089
37VRK21.60301058
38CDK61.47038612
39ILK1.42568223
40PIM11.31043630
41TESK21.26503992
42RPS6KC11.23588955
43RPS6KL11.23588955
44MAP2K21.23382381
45PRKD31.22518816
46CDC42BPA1.20025579
47MET1.15866180
48PHKG11.15064021
49PHKG21.15064021
50GSK3A1.12521004
51TTK1.07998624
52RPS6KA61.05798021
53CDK121.05334805
54MAPK111.03216917
55NEK61.01689688
56MAP3K121.01397595
57CHEK20.99968344
58BRSK10.98284302
59PRKCI0.97950337
60CDK80.95122082
61ARAF0.94561412
62MAP3K20.93899786
63MAP3K100.90019039
64PRPF4B0.88527983
65SRPK10.86987695
66PTK60.84501534
67HIPK20.84224508
68NEK10.83942630
69SIK30.83713221
70TSSK60.81270930
71DYRK30.80882208
72WEE10.79881942
73MAP3K30.78117202
74TAOK20.76011774
75PLK10.75240444
76MAP2K10.74696648
77LRRK20.73185601
78MTOR0.73109913
79TRIM280.72857901
80EPHA20.69333450
81RPS6KA20.69316701
82IRAK20.66129484
83KSR20.65826085
84RPS6KA10.65798047
85AKT20.64830447
86TAF10.64773188
87PRKAA10.64043655
88LIMK10.62042216
89PIK3CA0.57298732
90ERN10.57169670
91BRAF0.56682373
92TTN0.54505427
93CHUK0.54433684
94NME10.53577949
95PDPK10.52634243
96ERBB30.51364147
97FER0.50822074
98LATS10.50471562
99RPS6KB20.50192519
100LMTK20.46854617
101RAF10.45468124
102EGFR0.44437891
103CDK20.43592774
104MELK0.43088405
105MAP3K80.42082491
106RPS6KA40.41609671
107MAP3K90.41290151
108ATR0.41259632
109CDK90.40701654
110RET0.40595505
111FGFR40.40523480
112PDGFRB0.40159474
113PNCK0.39493341
114RPS6KB10.37217697
115STK30.37179954
116TRIB30.37106703
117CSNK2A10.36966744
118MAPK10.36314885
119CAMK2G0.36271599
120CAMK2B0.35521512
121MAPKAPK30.35131809
122MAPK30.34458151
123DYRK20.34183560
124CDC70.33798677
125PTK20.33681125
126MAPK100.33068177
127BRD40.33036713
128CDK40.32734056
129RIPK10.32561859
130TAOK10.30771998
131LYN0.29964224
132MAPK140.29672435
133PRKAA20.29514746
134AURKA0.29458622
135MAPK40.29450498
136CSNK1G10.29417559
137TNK20.29257328
138INSR0.29082646
139MAPKAPK20.27016249
140STK380.25680921
141ATM0.25404235
142CHEK10.24513813
143SGK10.21984783
144MARK20.21959587
145CSNK2A20.21755895
146ALK0.21710252
147CDK10.21412537
148PAK20.21260086
149CAMK2A0.20565288
150PRKD10.19817115
151FGFR10.19571153
152STK38L0.18719726
153CAMK2D0.18259999
154PRKCZ0.17082728
155CDK11A0.16884680
156AURKB0.16227611
157GSK3B0.15354967
158DMPK0.15285318
159CDK150.15273460
160NEK20.15042243
161RPS6KA30.14906331
162PRKCD0.14469587
163AKT10.13990021

Predicted pathways (KEGG)

RankGene SetZ-score
1Fatty acid biosynthesis_Homo sapiens_hsa000615.94309720
2Mismatch repair_Homo sapiens_hsa034304.57141070
3Base excision repair_Homo sapiens_hsa034104.45702178
4DNA replication_Homo sapiens_hsa030303.18772931
5Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005332.62540076
6Taurine and hypotaurine metabolism_Homo sapiens_hsa004302.50264844
7Hedgehog signaling pathway_Homo sapiens_hsa043402.47434632
8Hippo signaling pathway_Homo sapiens_hsa043902.36349321
9mTOR signaling pathway_Homo sapiens_hsa041502.26151328
10Notch signaling pathway_Homo sapiens_hsa043302.15986924
11Circadian rhythm_Homo sapiens_hsa047102.07885675
12Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa009702.07096097
13Adherens junction_Homo sapiens_hsa045202.00236831
14Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030081.99922099
15Arginine and proline metabolism_Homo sapiens_hsa003301.96847873
16Citrate cycle (TCA cycle)_Homo sapiens_hsa000201.93570418
17mRNA surveillance pathway_Homo sapiens_hsa030151.92609151
18Nucleotide excision repair_Homo sapiens_hsa034201.92102947
19Basal cell carcinoma_Homo sapiens_hsa052171.78829799
20p53 signaling pathway_Homo sapiens_hsa041151.75548581
21TGF-beta signaling pathway_Homo sapiens_hsa043501.67840994
22Non-small cell lung cancer_Homo sapiens_hsa052231.65878750
23RNA transport_Homo sapiens_hsa030131.64548282
24Pentose phosphate pathway_Homo sapiens_hsa000301.64339341
25Bladder cancer_Homo sapiens_hsa052191.63685198
26Spliceosome_Homo sapiens_hsa030401.61506404
27Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa005201.60927299
28Fanconi anemia pathway_Homo sapiens_hsa034601.60413211
29Wnt signaling pathway_Homo sapiens_hsa043101.49982883
30Proteasome_Homo sapiens_hsa030501.49617381
31Protein processing in endoplasmic reticulum_Homo sapiens_hsa041411.48661214
32Longevity regulating pathway - mammal_Homo sapiens_hsa042111.46314363
33Homologous recombination_Homo sapiens_hsa034401.44315812
34Fatty acid metabolism_Homo sapiens_hsa012121.38916128
35Sulfur relay system_Homo sapiens_hsa041221.38685836
36Biosynthesis of amino acids_Homo sapiens_hsa012301.38468333
37Transcriptional misregulation in cancer_Homo sapiens_hsa052021.38385996
38Pyrimidine metabolism_Homo sapiens_hsa002401.34561266
392-Oxocarboxylic acid metabolism_Homo sapiens_hsa012101.34443478
40Vitamin B6 metabolism_Homo sapiens_hsa007501.33521862
41Renal cell carcinoma_Homo sapiens_hsa052111.24062029
42Glioma_Homo sapiens_hsa052141.22611160
43Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa045501.19621635
44Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa049611.18530550
45VEGF signaling pathway_Homo sapiens_hsa043701.17293165
46N-Glycan biosynthesis_Homo sapiens_hsa005101.14317141
47Fructose and mannose metabolism_Homo sapiens_hsa000511.13978597
48Lysine degradation_Homo sapiens_hsa003101.13765242
49Folate biosynthesis_Homo sapiens_hsa007901.12916263
50Shigellosis_Homo sapiens_hsa051311.11846547
51Cell cycle_Homo sapiens_hsa041101.11811152
52Vibrio cholerae infection_Homo sapiens_hsa051101.11529009
53Pentose and glucuronate interconversions_Homo sapiens_hsa000401.09736219
54MicroRNAs in cancer_Homo sapiens_hsa052060.95954936
55Tight junction_Homo sapiens_hsa045300.95856382
56Regulation of actin cytoskeleton_Homo sapiens_hsa048100.95426717
57Carbon metabolism_Homo sapiens_hsa012000.93224943
58Cyanoamino acid metabolism_Homo sapiens_hsa004600.91348415
59Colorectal cancer_Homo sapiens_hsa052100.90121613
60Oocyte meiosis_Homo sapiens_hsa041140.87706840
61Pathogenic Escherichia coli infection_Homo sapiens_hsa051300.87356350
62Glycosaminoglycan degradation_Homo sapiens_hsa005310.87140329
63Dorso-ventral axis formation_Homo sapiens_hsa043200.85702342
64Phenylalanine metabolism_Homo sapiens_hsa003600.84867283
65Other types of O-glycan biosynthesis_Homo sapiens_hsa005140.84697464
66RNA polymerase_Homo sapiens_hsa030200.82093868
67Progesterone-mediated oocyte maturation_Homo sapiens_hsa049140.78429956
68ErbB signaling pathway_Homo sapiens_hsa040120.76364811
69Choline metabolism in cancer_Homo sapiens_hsa052310.75319016
70Maturity onset diabetes of the young_Homo sapiens_hsa049500.75246819
71Estrogen signaling pathway_Homo sapiens_hsa049150.72989409
72Arginine biosynthesis_Homo sapiens_hsa002200.72213064
73Gap junction_Homo sapiens_hsa045400.69293776
74Thyroid cancer_Homo sapiens_hsa052160.68779319
75Hepatitis C_Homo sapiens_hsa051600.68777305
76Acute myeloid leukemia_Homo sapiens_hsa052210.65231953
77Vasopressin-regulated water reabsorption_Homo sapiens_hsa049620.65129606
78Inositol phosphate metabolism_Homo sapiens_hsa005620.63669147
79Galactose metabolism_Homo sapiens_hsa000520.62764495
80Primary immunodeficiency_Homo sapiens_hsa053400.62445453
81Selenocompound metabolism_Homo sapiens_hsa004500.61847331
82Insulin resistance_Homo sapiens_hsa049310.61180178
83Proteoglycans in cancer_Homo sapiens_hsa052050.60972713
84AMPK signaling pathway_Homo sapiens_hsa041520.60715409
85Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001300.60675764
86Prolactin signaling pathway_Homo sapiens_hsa049170.60239190
87Prion diseases_Homo sapiens_hsa050200.59459743
88Viral myocarditis_Homo sapiens_hsa054160.59228166
89Chronic myeloid leukemia_Homo sapiens_hsa052200.58982944
90Basal transcription factors_Homo sapiens_hsa030220.58626078
91Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate_Homo sapiens_hsa005320.58040801
92Apoptosis_Homo sapiens_hsa042100.57648111
93Small cell lung cancer_Homo sapiens_hsa052220.57251270
94Non-homologous end-joining_Homo sapiens_hsa034500.57162985
95Neurotrophin signaling pathway_Homo sapiens_hsa047220.56731328
96Bacterial invasion of epithelial cells_Homo sapiens_hsa051000.54894279
97Glucagon signaling pathway_Homo sapiens_hsa049220.52785031
98Pyruvate metabolism_Homo sapiens_hsa006200.52666394
99Cysteine and methionine metabolism_Homo sapiens_hsa002700.51652223
100Ubiquitin mediated proteolysis_Homo sapiens_hsa041200.50994709
101Sphingolipid metabolism_Homo sapiens_hsa006000.49966455
102Arrhythmogenic right ventricular cardiomyopathy (ARVC)_Homo sapiens_hsa054120.48656081
103Insulin signaling pathway_Homo sapiens_hsa049100.48111378
104Hepatitis B_Homo sapiens_hsa051610.46374014
105Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa005340.45208576
106Ribosome_Homo sapiens_hsa030100.44916803
107Sulfur metabolism_Homo sapiens_hsa009200.44459723
108Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005630.43797930
109Phosphatidylinositol signaling system_Homo sapiens_hsa040700.43529143
110PI3K-Akt signaling pathway_Homo sapiens_hsa041510.42860271
111Viral carcinogenesis_Homo sapiens_hsa052030.41832920
112Fc epsilon RI signaling pathway_Homo sapiens_hsa046640.41583206
113MAPK signaling pathway_Homo sapiens_hsa040100.41449823
114Focal adhesion_Homo sapiens_hsa045100.41006257
115Endometrial cancer_Homo sapiens_hsa052130.40675981
116Steroid biosynthesis_Homo sapiens_hsa001000.39082921
117Central carbon metabolism in cancer_Homo sapiens_hsa052300.38172153
118Pathways in cancer_Homo sapiens_hsa052000.37432133
119Glutathione metabolism_Homo sapiens_hsa004800.36909684
120Mineral absorption_Homo sapiens_hsa049780.33896476
121Legionellosis_Homo sapiens_hsa051340.31870708
122Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002500.31023187
123Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049640.30478409
124Prostate cancer_Homo sapiens_hsa052150.30362774
125Linoleic acid metabolism_Homo sapiens_hsa005910.29598926
126Longevity regulating pathway - multiple species_Homo sapiens_hsa042130.26075015
127Rap1 signaling pathway_Homo sapiens_hsa040150.25447129
128Fatty acid elongation_Homo sapiens_hsa000620.25332143
129HTLV-I infection_Homo sapiens_hsa051660.24420675
130Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006030.23876397
131Endocytosis_Homo sapiens_hsa041440.22409775
132Melanoma_Homo sapiens_hsa052180.22360374
133alpha-Linolenic acid metabolism_Homo sapiens_hsa005920.21696944
134GnRH signaling pathway_Homo sapiens_hsa049120.21234227
135Pancreatic cancer_Homo sapiens_hsa052120.17406931
136Melanogenesis_Homo sapiens_hsa049160.16758819
137Arachidonic acid metabolism_Homo sapiens_hsa005900.16656435
138Thyroid hormone signaling pathway_Homo sapiens_hsa049190.14419575
139Herpes simplex infection_Homo sapiens_hsa051680.12723015
140One carbon pool by folate_Homo sapiens_hsa006700.12511652
141RNA degradation_Homo sapiens_hsa030180.11236539
142Fc gamma R-mediated phagocytosis_Homo sapiens_hsa046660.11059456

Most similar genes based on co-expression Upload to Enrichr

Tissue Expression Export image »

Cell Line Expression Export image »