HOXC5

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: This gene belongs to the homeobox family of genes. The homeobox genes encode a highly conserved family of transcription factors that play an important role in morphogenesis in all multicellular organisms. Mammals possess four similar homeobox gene clusters, HOXA, HOXB, HOXC and HOXD, which are located on different chromosomes and consist of 9 to 11 genes arranged in tandem. This gene, HOXC5, is one of several homeobox HOXC genes located in a cluster on chromosome 12. Three genes, HOXC5, HOXC4 and HOXC6, share a 5' non-coding exon. Transcripts may include the shared exon spliced to the gene-specific exons, or they may include only the gene-specific exons. Two alternatively spliced variants have been described for HOXC5. The transcript variant which includes the shared exon apparently doesn't encode a protein. The protein-coding transcript variant contains gene-specific exons only. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1outer ear morphogenesis (GO:0042473)5.62396741
2diaphragm development (GO:0060539)5.56196693
3skeletal muscle organ development (GO:0060538)5.31056549
4establishment of apical/basal cell polarity (GO:0035089)5.01224422
5mesenchymal-epithelial cell signaling (GO:0060638)4.93670497
6proline biosynthetic process (GO:0006561)4.82780429
7negative regulation of chondrocyte differentiation (GO:0032331)4.73412193
8protein retention in ER lumen (GO:0006621)4.66335660
9proximal/distal pattern formation (GO:0009954)4.56789325
10establishment or maintenance of monopolar cell polarity (GO:0061339)4.44906370
11establishment of monopolar cell polarity (GO:0061162)4.44906370
12embryonic process involved in female pregnancy (GO:0060136)4.33888342
13negative regulation of cartilage development (GO:0061037)4.25009828
14maintenance of protein localization in endoplasmic reticulum (GO:0035437)4.23917891
15peptidyl-proline hydroxylation (GO:0019511)4.12394361
16protein heterotrimerization (GO:0070208)4.11479660
17GDP-mannose metabolic process (GO:0019673)4.08663321
18ribosomal small subunit biogenesis (GO:0042274)4.01589044
19lung-associated mesenchyme development (GO:0060484)4.00000699
20respiratory tube development (GO:0030323)3.98923543
21axon extension involved in axon guidance (GO:0048846)3.94005437
22neuron projection extension involved in neuron projection guidance (GO:1902284)3.94005437
23cranial nerve morphogenesis (GO:0021602)3.91162026
24lateral sprouting from an epithelium (GO:0060601)3.88837144
25facial nerve structural organization (GO:0021612)3.81758978
26paraxial mesoderm development (GO:0048339)3.76211908
27convergent extension (GO:0060026)3.71807371
28protein hydroxylation (GO:0018126)3.67411768
29planar cell polarity pathway involved in neural tube closure (GO:0090179)3.64830936
30respiratory system process (GO:0003016)3.62333646
314-hydroxyproline metabolic process (GO:0019471)3.58220940
32peptidyl-lysine dimethylation (GO:0018027)3.57367196
33endothelial cell chemotaxis (GO:0035767)3.53787247
34muscle cell fate commitment (GO:0042693)3.51885074
35folic acid metabolic process (GO:0046655)3.51415456
36face development (GO:0060324)3.51310735
37protein maturation by protein folding (GO:0022417)3.50199442
38glial cell migration (GO:0008347)3.49282883
39outflow tract septum morphogenesis (GO:0003148)3.47177349
40transcription from mitochondrial promoter (GO:0006390)3.44623852
41cartilage morphogenesis (GO:0060536)3.42640555
42thyroid gland development (GO:0030878)3.41184249
43embryonic camera-type eye development (GO:0031076)3.40990990
44polarized epithelial cell differentiation (GO:0030859)3.38514338
45regulation of integrin activation (GO:0033623)3.38375658
46proline metabolic process (GO:0006560)3.36091116
47regulation of establishment of planar polarity involved in neural tube closure (GO:0090178)3.33382967
48spliceosomal tri-snRNP complex assembly (GO:0000244)3.27941802
49pre-miRNA processing (GO:0031054)3.21531972
50cell-substrate adherens junction assembly (GO:0007045)3.21275037
51focal adhesion assembly (GO:0048041)3.21275037
52synapsis (GO:0007129)3.20251898
53embryonic skeletal joint morphogenesis (GO:0060272)3.19396086
54negative regulation of JAK-STAT cascade (GO:0046426)3.18811978
55replication fork processing (GO:0031297)3.16206306
56head development (GO:0060322)3.15768228
57organ induction (GO:0001759)3.15342236
58motor neuron axon guidance (GO:0008045)3.15212729
59cochlea morphogenesis (GO:0090103)3.14379643
60kidney mesenchyme development (GO:0072074)3.14043627
61male meiosis I (GO:0007141)3.12711838
62hippo signaling (GO:0035329)3.12571516
63vitamin A metabolic process (GO:0006776)3.12301380
64hindlimb morphogenesis (GO:0035137)3.12179136
65anatomical structure regression (GO:0060033)3.11755024
66mesenchymal to epithelial transition involved in metanephros morphogenesis (GO:0003337)3.07395538
67embryonic hindlimb morphogenesis (GO:0035116)3.05279630
68organ formation (GO:0048645)3.04574258
69neuron fate specification (GO:0048665)3.03577762
70positive regulation of protein homooligomerization (GO:0032464)3.00844341
71middle ear morphogenesis (GO:0042474)3.00637798
72positive regulation of type I interferon-mediated signaling pathway (GO:0060340)2.98597601
73regulation of Wnt signaling pathway, planar cell polarity pathway (GO:2000095)2.98376666
74cell morphogenesis involved in neuron differentiation (GO:0048667)2.98183831
75mannose metabolic process (GO:0006013)2.97808374
76negative regulation of catenin import into nucleus (GO:0035414)2.97591951
77cartilage development involved in endochondral bone morphogenesis (GO:0060351)2.97446958
78embryonic skeletal system morphogenesis (GO:0048704)2.97340657
79dosage compensation (GO:0007549)2.96800943
80ribosome biogenesis (GO:0042254)2.95289096
81regulation of mammary gland epithelial cell proliferation (GO:0033599)2.94776796
82chromosome organization involved in meiosis (GO:0070192)2.93278098
83glomerular basement membrane development (GO:0032836)2.93276293
84nucleotide-sugar biosynthetic process (GO:0009226)2.90376658
85regulation of sister chromatid cohesion (GO:0007063)2.88903491
86negative regulation of mRNA splicing, via spliceosome (GO:0048025)2.88898927
87synaptonemal complex assembly (GO:0007130)2.88111517
88negative regulation of cell cycle arrest (GO:0071157)2.87726880
89regulation of protein homooligomerization (GO:0032462)2.87479345
90craniofacial suture morphogenesis (GO:0097094)2.86871916
91mitotic nuclear envelope reassembly (GO:0007084)2.86257288
92nuclear envelope reassembly (GO:0031468)2.86257288
93metanephric mesenchyme development (GO:0072075)2.86232584
94body morphogenesis (GO:0010171)2.85966876
95type B pancreatic cell proliferation (GO:0044342)2.85469274
96post-embryonic morphogenesis (GO:0009886)2.85285679
97cranial nerve structural organization (GO:0021604)2.83768540
98viral transcription (GO:0019083)2.82808949
99mammary gland epithelial cell differentiation (GO:0060644)2.81921350
100meiosis I (GO:0007127)2.81864778
101regulation of cAMP-dependent protein kinase activity (GO:2000479)2.79896538
102regulation of skeletal muscle contraction (GO:0014819)2.78443410
103non-canonical Wnt signaling pathway (GO:0035567)2.78062298
104viral mRNA export from host cell nucleus (GO:0046784)2.77776033
105cell migration in hindbrain (GO:0021535)2.76585879
106bone trabecula formation (GO:0060346)2.76376536
107positive regulation of developmental pigmentation (GO:0048087)2.75487027
108peptidyl-arginine omega-N-methylation (GO:0035247)2.75238430
109adherens junction assembly (GO:0034333)2.74631416
110* anterior/posterior pattern specification (GO:0009952)2.74536737
111DNA replication checkpoint (GO:0000076)2.73647286
112embryonic organ morphogenesis (GO:0048562)2.73585083
113oxidative demethylation (GO:0070989)2.73582390
114embryonic forelimb morphogenesis (GO:0035115)2.72655462
115oogenesis (GO:0048477)2.72582299
116mesenchymal to epithelial transition (GO:0060231)2.72211519
117cell proliferation involved in metanephros development (GO:0072203)2.70285434
118anatomical structure arrangement (GO:0048532)2.69948912
119positive regulation of metanephros development (GO:0072216)2.69065279
120regulation of chondrocyte differentiation (GO:0032330)2.69027380
121response to pheromone (GO:0019236)2.68856146
122embryonic eye morphogenesis (GO:0048048)2.68445250
123ribonucleoprotein complex biogenesis (GO:0022613)2.67929467
124mesenchymal cell proliferation (GO:0010463)2.66177468
125skeletal system morphogenesis (GO:0048705)2.65213673
126artery development (GO:0060840)2.65195528
127regulation of translational fidelity (GO:0006450)2.63634090
128eyelid development in camera-type eye (GO:0061029)2.63436753
129regulation of cartilage development (GO:0061035)2.63379292
130embryonic viscerocranium morphogenesis (GO:0048703)2.63038340
131translational termination (GO:0006415)2.62853642
132regulation of RNA export from nucleus (GO:0046831)2.62579710
133regulation of chromatin binding (GO:0035561)2.59622061
134pyrimidine-containing compound salvage (GO:0008655)2.59263059
135pyrimidine nucleoside salvage (GO:0043097)2.59263059
136histone arginine methylation (GO:0034969)2.59180550
137DNA integration (GO:0015074)2.58842156
138gastrulation with mouth forming second (GO:0001702)2.57896023
139lymph vessel development (GO:0001945)2.57505662
140DNA topological change (GO:0006265)2.57100238
141regulation of apoptotic process involved in morphogenesis (GO:1902337)2.56877180
142pseudouridine synthesis (GO:0001522)2.56796785
143pattern specification involved in kidney development (GO:0061004)2.55291119
144heart trabecula formation (GO:0060347)2.54946632
145DNA methylation involved in gamete generation (GO:0043046)2.54820368
146negative regulation of Ras GTPase activity (GO:0034261)2.54134337
147collagen fibril organization (GO:0030199)2.52831377
148mesenchyme development (GO:0060485)2.52819654
149DNA strand renaturation (GO:0000733)2.52419911
150rRNA transcription (GO:0009303)2.52339477
151ncRNA 3-end processing (GO:0043628)2.51950358
152forelimb morphogenesis (GO:0035136)2.51566312
153G-protein coupled receptor signaling pathway coupled to cGMP nucleotide second messenger (GO:00071992.50806819
154regulation of single stranded viral RNA replication via double stranded DNA intermediate (GO:00450912.50417886
155response to misfolded protein (GO:0051788)2.50129530
156* embryonic skeletal system development (GO:0048706)2.49890468
157negative regulation of DNA damage response, signal transduction by p53 class mediator (GO:0043518)2.49036429
158negative regulation of cell size (GO:0045792)2.48838464
159DNA unwinding involved in DNA replication (GO:0006268)2.48765994
160cell-substrate junction assembly (GO:0007044)2.48095004
161embryonic body morphogenesis (GO:0010172)2.47043131
162maturation of SSU-rRNA (GO:0030490)2.46742914
163grooming behavior (GO:0007625)2.45855570
164mitotic metaphase plate congression (GO:0007080)2.44856154
165ventricular cardiac muscle cell development (GO:0055015)2.44593169
166pharyngeal system development (GO:0060037)2.44542984
167translational elongation (GO:0006414)2.43734055
168embryonic cranial skeleton morphogenesis (GO:0048701)2.40667232
169regulation of heart morphogenesis (GO:2000826)2.39447533
170synaptonemal complex organization (GO:0070193)2.35319853
171cellular response to ATP (GO:0071318)2.33377138
172nucleoside salvage (GO:0043174)2.32711414
173DNA synthesis involved in DNA repair (GO:0000731)2.32703887
174base-excision repair, AP site formation (GO:0006285)2.29669609
175misfolded or incompletely synthesized protein catabolic process (GO:0006515)2.28649311
176apoptotic process involved in morphogenesis (GO:0060561)2.28639624
177nuclear-transcribed mRNA catabolic process, nonsense-mediated decay (GO:0000184)2.28344540
178sensory perception of taste (GO:0050909)2.27485422
179heterochromatin organization (GO:0070828)2.26997858
180regulation of vascular endothelial growth factor signaling pathway (GO:1900746)2.26950171
181positive regulation of protein kinase C signaling (GO:0090037)2.26781808
182regulation of cellular response to vascular endothelial growth factor stimulus (GO:1902547)2.26484525
183translational initiation (GO:0006413)2.24314428

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1ZFP281_18358816_ChIP-ChIP_MESCs_Mouse3.71983708
2KLF2_18264089_ChIP-ChIP_MESCs_Mouse3.61769989
3KLF5_18264089_ChIP-ChIP_MESCs_Mouse3.61769989
4KLF4_18264089_ChIP-ChIP_MESCs_Mouse3.61769989
5TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat3.49777928
6TRIM28_21343339_ChIP-Seq_HEK293_Human3.35486749
7HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse3.29737349
8PPARG_19300518_ChIP-PET_3T3-L1_Mouse3.13692347
9TP63_19390658_ChIP-ChIP_HaCaT_Human2.98764732
10NANOG_18700969_ChIP-ChIP_MESCs_Mouse2.98400738
11ZFP281_18757296_ChIP-ChIP_E14_Mouse2.55476500
12* TP53_20018659_ChIP-ChIP_R1E_Mouse2.29807002
13SMAD3_22036565_ChIP-Seq_ESCs_Mouse2.27955461
14STAT6_21828071_ChIP-Seq_BEAS2B_Human2.21792084
15HCFC1_20581084_ChIP-Seq_MESCs_Mouse2.19165720
16SALL1_21062744_ChIP-ChIP_HESCs_Human2.10768504
17TP63_17297297_ChIP-ChIP_HaCaT_Human2.06526760
18SMAD1_18555785_ChIP-Seq_MESCs_Mouse2.03447518
19FOXM1_23109430_ChIP-Seq_U2OS_Human1.97775899
20ZFP281_27345836_Chip-Seq_ESCs_Mouse1.97569516
21WT1_20215353_ChIP-ChIP_NEPHRON_PROGENITOR_Mouse1.97552428
22EZH2_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse1.96161030
23SOX2_18358816_ChIP-ChIP_MESCs_Mouse1.95491796
24CTNNB1_20615089_ChIP-ChIP_FETAL_BRAIN_Human1.94822773
25HOXD13_18407260_ChIP-ChIP_DEVELOPING-LIMBS_Mouse1.92566537
26JARID1A_20064375_ChIP-Seq_MESCs_Mouse1.92112964
27RARG_19884340_ChIP-ChIP_MEFs_Mouse1.91853520
28NUCKS1_24931609_ChIP-Seq_HEPATOCYTES_Mouse1.90277936
29CTNNB1_24651522_ChIP-Seq_LGR5+_INTESTINAL_STEM_Human1.90180521
30ERG_21242973_ChIP-ChIP_JURKAT_Human1.89063515
31SALL4_18804426_ChIP-ChIP_MESCs_Mouse1.88681742
32MYC_18358816_ChIP-ChIP_MESCs_Mouse1.87597889
33CLOCK_20551151_ChIP-Seq_293T_Human1.87376951
34EP300_20729851_ChIP-Seq_FORBRAIN_MIDBRAIN_LIMB_HEART_Mouse1.86352677
35DACH1_20351289_ChIP-Seq_MDA-MB-231_Human1.84923616
36MYC_18555785_ChIP-Seq_MESCs_Mouse1.79271087
37* KLF4_18358816_ChIP-ChIP_MESCs_Mouse1.75880980
38RING1B_27294783_Chip-Seq_NPCs_Mouse1.71993920
39P68_20966046_ChIP-Seq_HELA_Human1.70422156
40MYBL1_21750041_ChIP-ChIP_SPERMATOCYTES_Mouse1.69066756
41GLI1_17442700_ChIP-ChIP_MESCs_Mouse1.64620681
42THAP11_20581084_ChIP-Seq_MESCs_Mouse1.63633870
43ESR1_15608294_ChIP-ChIP_MCF-7_Human1.61952951
44CCND1_20090754_ChIP-ChIP_RETINA_Mouse1.61681324
45LXR_22292898_ChIP-Seq_THP-1_Human1.59922211
46* PHC1_16625203_ChIP-ChIP_MESCs_Mouse1.59435847
47POU5F1_16518401_ChIP-PET_MESCs_Mouse1.59303445
48ZIC3_20872845_ChIP-ChIP_MESCs_Mouse1.59133314
49TCF3_18692474_ChIP-Seq_MEFs_Mouse1.59006018
50NANOG_21062744_ChIP-ChIP_HESCs_Human1.58908979
51POU5F1_16153702_ChIP-ChIP_HESCs_Human1.58279675
52TCF3_18467660_ChIP-ChIP_MESCs_Mouse1.58236111
53ELK3_25401928_ChIP-Seq_HUVEC_Human1.57689688
54* CDX2_20551321_ChIP-Seq_CACO-2_Human1.56224127
55TCF3_18692474_ChIP-Seq_MESCs_Mouse1.54400890
56KLF4_19030024_ChIP-ChIP_MESCs_Mouse1.53134915
57DCP1A_22483619_ChIP-Seq_HELA_Human1.53120471
58P300_27058665_Chip-Seq_ZR-75-30cells_Human1.50403999
59CEBPB_24764292_ChIP-Seq_MC3T3_Mouse1.48960380
60MYCN_27167114_Chip-Seq_NEUROBLASTOMA_Human1.44931727
61DMRT1_21621532_ChIP-ChIP_FETAL_Ovary1.42331729
62FOXM1_25889361_ChIP-Seq_OE33_AND_U2OS_Human1.42033066
63MYC_19079543_ChIP-ChIP_MESCs_Mouse1.41339252
64RUNX2_24764292_ChIP-Seq_MC3T3_Mouse1.41052034
65SA1_27219007_Chip-Seq_ERYTHROID_Human1.40002018
66RACK7_27058665_Chip-Seq_MCF-7_Human1.39493393
67CREB1_26743006_Chip-Seq_LNCaP-abl_Human1.38129256
68HIF1A_21447827_ChIP-Seq_MCF-7_Human1.37189006
69GABP_19822575_ChIP-Seq_HepG2_Human1.37085744
70MYC_19030024_ChIP-ChIP_MESCs_Mouse1.37083405
71TTF2_22483619_ChIP-Seq_HELA_Human1.37011535
72ETS1_20019798_ChIP-Seq_JURKAT_Human1.36885312
73SRY_22984422_ChIP-ChIP_TESTIS_Rat1.35717415
74DMRT1_23473982_ChIP-Seq_TESTES_Mouse1.35401372
75* CTCF_27219007_Chip-Seq_ERYTHROID_Human1.35171778
76VDR_21846776_ChIP-Seq_THP-1_Human1.34970404
77CTCF_27219007_Chip-Seq_Bcells_Human1.34954006
78ZFX_18555785_ChIP-Seq_MESCs_Mouse1.34936336
79SMC4_20622854_ChIP-Seq_HELA_Human1.34646488
80TBP_23326641_ChIP-Seq_C3H10T1-2_Mouse1.33016493
81CHD7_19251738_ChIP-ChIP_MESCs_Mouse1.31862041
82EKLF_21900194_ChIP-Seq_ERYTHROCYTE_Mouse1.31325538
83ZNF263_19887448_ChIP-Seq_K562_Human1.31091811
84* FOXP1_21924763_ChIP-Seq_HESCs_Human1.30535480
85ATF3_27146783_Chip-Seq_COLON_Human1.29991898
86NANOG_18347094_ChIP-ChIP_MESCs_Mouse1.29413820
87STAT3_19079543_ChIP-ChIP_MESCs_Mouse1.29322747
88KDM2B_26808549_Chip-Seq_K562_Human1.28071213
89KDM5A_27292631_Chip-Seq_BREAST_Human1.26820715
90* E2F1_20622854_ChIP-Seq_HELA_Human1.26723271
91EZH2_27304074_Chip-Seq_ESCs_Mouse1.26053113
92EZH2_22144423_ChIP-Seq_EOC_Human1.25412529
93SOX2_18555785_ChIP-Seq_MESCs_Mouse1.24424773
94POU5F1_18700969_ChIP-ChIP_MESCs_Mouse1.23717754
95KDM2B_26808549_Chip-Seq_SUP-B15_Human1.23667486
96UBF1/2_26484160_Chip-Seq_HMECs_Human1.23142038
97HSF1_23293686_ChIP-Seq_STHDH_STRIATAL_Mouse1.22172669
98SIN3A_21632747_ChIP-Seq_MESCs_Mouse1.22165887
99* CTCF_21964334_Chip-Seq_Bcells_Human1.22059993
100SETDB1_19884255_ChIP-Seq_MESCs_Mouse1.21997993
101* EED_16625203_ChIP-ChIP_MESCs_Mouse1.21596677
102* CTCF_18555785_ChIP-Seq_MESCs_Mouse1.21214167
103CREB1_23762244_ChIP-Seq_HIPPOCAMPUS_Rat1.20685167
104UBF1/2_26484160_Chip-Seq_HMEC-DERIVED_Human1.20172808
105EGR1_20690147_ChIP-Seq_ERYTHROLEUKEMIA_Human1.18820061
106OLIG2_26023283_ChIP-Seq_AINV15_Mouse1.18719290
107TFAP2C_20629094_ChIP-Seq_MCF-7_Human1.18343101
108TAF7L_23326641_ChIP-Seq_C3H10T1-2_Mouse1.17493747
109ESR1_20079471_ChIP-ChIP_T-47D_Human1.17225736
110POU5F1_18358816_ChIP-ChIP_MESCs_Mouse1.16776266
111CREB1_20920259_ChIP-Seq_GC1-SPG_Mouse1.16590220
112* SRY_25088423_ChIP-ChIP_EMBRYONIC_GONADS_Mouse1.16567289
113* RNF2_18974828_ChIP-Seq_MESCs_Mouse1.15481561
114* EZH2_18974828_ChIP-Seq_MESCs_Mouse1.15481561
115* TCF3_18347094_ChIP-ChIP_MESCs_Mouse1.15238582
116* BMI1_23680149_ChIP-Seq_NPCS_Mouse1.15187811
117NR0B1_18358816_ChIP-ChIP_MESCs_Mouse1.15142126
118PHF8_20622854_ChIP-Seq_HELA_Human1.14754352
119RING1B_27294783_Chip-Seq_ESCs_Mouse1.13822312
120KLF4_18555785_ChIP-Seq_MESCs_Mouse1.13232017
121PPARD_23176727_ChIP-Seq_KERATINOCYTES_Mouse1.12717628
122RBPJ_22232070_ChIP-Seq_NCS_Mouse1.12494390
123NOTCH1_17114293_ChIP-ChIP_T-ALL_Human1.12438625
124KLF6_26769127_Chip-Seq_PDAC-Cell_line_Human1.12092879
125SOX9_25088423_ChIP-ChIP_EMBRYONIC_GONADS_Mouse1.11817757
126* CTCF_26484167_Chip-Seq_Bcells_Mouse1.11463056
127KDM2B_26808549_Chip-Seq_DND41_Human1.11316223
128* BCOR_27268052_Chip-Seq_Bcells_Human1.11038013
129TBX5_21415370_ChIP-Seq_HL-1_Mouse1.09006355
130* JARID2_20075857_ChIP-Seq_MESCs_Mouse1.07892795
131TP53_22127205_ChIP-Seq_IMR90_Human1.06993534
132TET1_21451524_ChIP-Seq_MESCs_Mouse1.06736782
133MYC_22102868_ChIP-Seq_BL_Human1.06036495
134* BCL6_27268052_Chip-Seq_Bcells_Human1.05914956
135E2F7_22180533_ChIP-Seq_HELA_Human1.05428090
136ESR2_21235772_ChIP-Seq_MCF-7_Human1.05418735
137KDM5B_21448134_ChIP-Seq_MESCs_Mouse1.05371769
138KDM2B_26808549_Chip-Seq_JURKAT_Human1.04132429
139EOMES_20176728_ChIP-ChIP_TSCs_Mouse1.04100922
140KDM2B_26808549_Chip-Seq_SIL-ALL_Human1.04098663
141NFIB_24661679_ChIP-Seq_LUNG_Mouse1.03936669
142BCL3_23251550_ChIP-Seq_MUSCLE_Mouse1.03770171
143CREB1_26743006_Chip-Seq_LNCaP_Human1.02785525
144CBX2_27304074_Chip-Seq_ESCs_Mouse1.02066516
145* RNF2_16625203_ChIP-ChIP_MESCs_Mouse1.00587423
146NACC1_18358816_ChIP-ChIP_MESCs_Mouse1.00488236
147NANOG_16153702_ChIP-ChIP_HESCs_Human0.99983867
148RUNX1_26923725_Chip-Seq_MACROPHAGESS_Mouse0.99797546
149TCFAP2C_20176728_ChIP-ChIP_TROPHOBLAST_STEM_CELLS_Mouse0.99778392
150KLF4_26769127_Chip-Seq_PDAC-Cell_line_Human0.99297092
151FOXM1_26100407_CHIP-SEQ_Hek293_flp-in_Human0.99046448
152* OCT4_18692474_ChIP-Seq_MEFs_Mouse0.97974438
153XRN2_22483619_ChIP-Seq_HELA_Human0.96789170
154* SOX2_18692474_ChIP-Seq_MEFs_Mouse0.96716149

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0010030_abnormal_orbit_morphology4.60187375
2MP0002249_abnormal_larynx_morphology3.18338739
3MP0002282_abnormal_trachea_morphology3.12423906
4MP0008438_abnormal_cutaneous_collagen2.96917483
5MP0004858_abnormal_nervous_system2.70888383
6MP0003385_abnormal_body_wall2.61043841
7MP0004233_abnormal_muscle_weight2.54905628
8MP0005257_abnormal_intraocular_pressure2.54167600
9MP0003283_abnormal_digestive_organ2.37307550
10MP0009250_abnormal_appendicular_skeleto2.37159713
11MP0003705_abnormal_hypodermis_morpholog2.36732467
12MP0003942_abnormal_urinary_system2.35755253
13MP0009053_abnormal_anal_canal2.31362458
14MP0005623_abnormal_meninges_morphology2.25796375
15MP0002932_abnormal_joint_morphology2.25075666
16MP0005503_abnormal_tendon_morphology2.15035301
17MP0000537_abnormal_urethra_morphology2.05841615
18MP0000049_abnormal_middle_ear1.97365325
19MP0005508_abnormal_skeleton_morphology1.93152979
20MP0003122_maternal_imprinting1.89103523
21MP0002108_abnormal_muscle_morphology1.89000031
22MP0000534_abnormal_ureter_morphology1.85014559
23MP0009278_abnormal_bone_marrow1.82859865
24MP0003123_paternal_imprinting1.80468430
25MP0004272_abnormal_basement_membrane1.79775446
26MP0005171_absent_coat_pigmentation1.77943479
27MP0000681_abnormal_thyroid_gland1.74952045
28MP0002114_abnormal_axial_skeleton1.74071551
29MP0004197_abnormal_fetal_growth/weight/1.72708339
30MP0003693_abnormal_embryo_hatching1.71346752
31MP0003755_abnormal_palate_morphology1.69026439
32MP0005275_abnormal_skin_tensile1.68462039
33MP0003119_abnormal_digestive_system1.67728604
34MP0005248_abnormal_Harderian_gland1.65596912
35MP0002877_abnormal_melanocyte_morpholog1.64039788
36MP0003950_abnormal_plasma_membrane1.63369247
37MP0000467_abnormal_esophagus_morphology1.60195893
38MP0002234_abnormal_pharynx_morphology1.57140017
39MP0008057_abnormal_DNA_replication1.55436744
40MP0003935_abnormal_craniofacial_develop1.52995669
41MP0003567_abnormal_fetal_cardiomyocyte1.51346139
42MP0009384_cardiac_valve_regurgitation1.49335871
43MP0002160_abnormal_reproductive_system1.48008643
44MP0002938_white_spotting1.46201848
45MP0003077_abnormal_cell_cycle1.43423825
46MP0001879_abnormal_lymphatic_vessel1.43040765
47MP0002116_abnormal_craniofacial_bone1.42690704
48MP0003115_abnormal_respiratory_system1.41147554
49MP0010352_gastrointestinal_tract_polyps1.40606606
50MP0004185_abnormal_adipocyte_glucose1.39521330
51MP0000428_abnormal_craniofacial_morphol1.39263615
52MP0005501_abnormal_skin_physiology1.38220536
53MP0002111_abnormal_tail_morphology1.37012095
54MP0000750_abnormal_muscle_regeneration1.36665141
55MP0001340_abnormal_eyelid_morphology1.36617213
56MP0003111_abnormal_nucleus_morphology1.34719260
57MP0002009_preneoplasia1.33598423
58MP0001293_anophthalmia1.32401744
59MP0000762_abnormal_tongue_morphology1.30703977
60MP0002085_abnormal_embryonic_tissue1.30172117
61MP0004134_abnormal_chest_morphology1.29604196
62MP0005076_abnormal_cell_differentiation1.29268154
63MP0001958_emphysema1.27511365
64MP0001346_abnormal_lacrimal_gland1.26408311
65MP0002177_abnormal_outer_ear1.23650716
66MP0008932_abnormal_embryonic_tissue1.23525457
67MP0005423_abnormal_somatic_nervous1.23073806
68MP0000759_abnormal_skeletal_muscle1.22852433
69MP0002084_abnormal_developmental_patter1.22791968
70MP0005666_abnormal_adipose_tissue1.20707775
71MP0002269_muscular_atrophy1.20383629
72MP0000733_abnormal_muscle_development1.20357508
73MP0005409_darkened_coat_color1.20237959
74MP0005330_cardiomyopathy1.19194170
75MP0000013_abnormal_adipose_tissue1.18227652
76MP0000462_abnormal_digestive_system1.17411257
77MP0001661_extended_life_span1.16402098
78MP0000751_myopathy1.14586724
79MP0003937_abnormal_limbs/digits/tail_de1.14513142
80MP0000678_abnormal_parathyroid_gland1.14014648
81MP0005670_abnormal_white_adipose1.13267127
82MP0009379_abnormal_foot_pigmentation1.10515122
83MP0000163_abnormal_cartilage_morphology1.10454163
84MP0000432_abnormal_head_morphology1.10380648
85MP0000579_abnormal_nail_morphology1.09571761
86MP0005367_renal/urinary_system_phenotyp1.09049802
87MP0000516_abnormal_urinary_system1.09049802
88MP0004957_abnormal_blastocyst_morpholog1.08981460
89MP0002210_abnormal_sex_determination1.07362622
90MP0003121_genomic_imprinting1.06381824
91MP0000747_muscle_weakness1.05406494
92MP0005187_abnormal_penis_morphology1.04933209
93MP0002109_abnormal_limb_morphology1.04726021
94MP0001697_abnormal_embryo_size1.04620737
95MP0000955_abnormal_spinal_cord1.03827010
96MP0000538_abnormal_urinary_bladder1.03601745
97MP0001299_abnormal_eye_distance/1.03282496
98MP0003938_abnormal_ear_development1.02047585
99MP0003941_abnormal_skin_development1.00976194
100MP0006276_abnormal_autonomic_nervous1.00094417
101MP0000749_muscle_degeneration0.97164976
102MP0010094_abnormal_chromosome_stability0.96869813
103MP0000767_abnormal_smooth_muscle0.96349070
104MP0001188_hyperpigmentation0.96151350
105MP0002086_abnormal_extraembryonic_tissu0.95646119
106MP0010368_abnormal_lymphatic_system0.95599698
107MP0005375_adipose_tissue_phenotype0.94975677
108MP0003279_aneurysm0.94699429
109MP0002332_abnormal_exercise_endurance0.94533719
110MP0000350_abnormal_cell_proliferation0.94381233
111MP0002115_abnormal_skeleton_extremities0.90864902
112MP0005174_abnormal_tail_pigmentation0.90663792
113MP0001270_distended_abdomen0.90175705
114MP0003566_abnormal_cell_adhesion0.89562831
115MP0003315_abnormal_perineum_morphology0.88881194
116MP0003453_abnormal_keratinocyte_physiol0.88335458
117MP0002697_abnormal_eye_size0.88180429
118MP0005083_abnormal_biliary_tract0.87233889
119MP0005380_embryogenesis_phenotype0.87210192
120MP0001672_abnormal_embryogenesis/_devel0.87210192
121MP0009115_abnormal_fat_cell0.87179763
122MP0002081_perinatal_lethality0.86873676
123MP0002060_abnormal_skin_morphology0.85935336
124MP0010771_integument_phenotype0.85624184
125MP0001348_abnormal_lacrimal_gland0.85044500
126MP0006054_spinal_hemorrhage0.84639359
127MP0003861_abnormal_nervous_system0.84357919
128MP0003890_abnormal_embryonic-extraembry0.84283914
129MP0000639_abnormal_adrenal_gland0.79077754
130MP0003011_delayed_dark_adaptation0.78594757
131MP0005023_abnormal_wound_healing0.78255940
132MP0004130_abnormal_muscle_cell0.77758698
133MP0001915_intracranial_hemorrhage0.76968380
134MP0002735_abnormal_chemical_nociception0.76766772
135MP0002184_abnormal_innervation0.76742699
136MP0000003_abnormal_adipose_tissue0.76286201
137MP0001175_abnormal_lung_morphology0.75796781
138MP0002925_abnormal_cardiovascular_devel0.75558566
139MP0004087_abnormal_muscle_fiber0.75534435
140MP0002796_impaired_skin_barrier0.75497860
141MP0001145_abnormal_male_reproductive0.75327600
142MP0001177_atelectasis0.74301104
143MP0008770_decreased_survivor_rate0.72734316
144MP0003879_abnormal_hair_cell0.71857002
145MP0002113_abnormal_skeleton_development0.69003570
146MP0000653_abnormal_sex_gland0.67819185
147MP0002098_abnormal_vibrissa_morphology0.67504372
148MP0003959_abnormal_lean_body0.65964364
149MP0005645_abnormal_hypothalamus_physiol0.65701913

Predicted human phenotypes

RankGene SetZ-score
1Rectal fistula (HP:0100590)5.92656990
2Rectovaginal fistula (HP:0000143)5.92656990
3Vaginal fistula (HP:0004320)5.37771171
4Intestinal fistula (HP:0100819)5.28069999
5Turricephaly (HP:0000262)4.66347421
6Coronal craniosynostosis (HP:0004440)4.47081357
7Septate vagina (HP:0001153)4.03499513
8Testicular atrophy (HP:0000029)3.94632547
9Concave nail (HP:0001598)3.78730741
10Annular pancreas (HP:0001734)3.77788427
11Aplasia/Hypoplasia of the sacrum (HP:0008517)3.76160691
12Bicornuate uterus (HP:0000813)3.60425604
13Short 4th metacarpal (HP:0010044)3.46782964
14Aplasia/Hypoplasia of the 4th metacarpal (HP:0010042)3.46782964
15Persistence of primary teeth (HP:0006335)3.37445664
16Periauricular skin pits (HP:0100277)3.34066346
17Preauricular pit (HP:0004467)3.34066346
18Protrusio acetabuli (HP:0003179)3.31738550
19Shallow orbits (HP:0000586)3.28259572
20Ulnar bowing (HP:0003031)3.28201952
21Lip pit (HP:0100267)3.27213039
22Premature rupture of membranes (HP:0001788)3.02187280
23Abnormality of the phalanges of the hallux (HP:0010057)3.02135066
24Facial hemangioma (HP:0000329)3.01977960
25Cerebral aneurysm (HP:0004944)2.96676786
26Rib fusion (HP:0000902)2.95797179
27Abnormality of the 4th metacarpal (HP:0010012)2.91322089
28Broad toe (HP:0001837)2.75096799
29Short nail (HP:0001799)2.71448037
30Anteriorly placed anus (HP:0001545)2.70245469
31Calcaneovalgus deformity (HP:0001848)2.63780537
32Microretrognathia (HP:0000308)2.63671419
33Skin pits (HP:0100276)2.63113615
34Renal duplication (HP:0000075)2.62218940
35Anal stenosis (HP:0002025)2.61060153
36Progressive muscle weakness (HP:0003323)2.53202316
37Germ cell neoplasia (HP:0100728)2.51036915
38Alacrima (HP:0000522)2.48823351
39Pulmonary artery stenosis (HP:0004415)2.45616799
40Broad metatarsal (HP:0001783)2.44936018
41Natal tooth (HP:0000695)2.42864300
42Breast hypoplasia (HP:0003187)2.41807101
43Cervical subluxation (HP:0003308)2.40888949
44Self-mutilation (HP:0000742)2.40341217
45Congenital stationary night blindness (HP:0007642)2.40317694
46Progressive external ophthalmoplegia (HP:0000590)2.39423991
47Deformed tarsal bones (HP:0008119)2.36090613
48Midline defect of the nose (HP:0004122)2.35166147
49Short humerus (HP:0005792)2.34857202
50Broad hallux (HP:0010055)2.32053749
51Broad thumb (HP:0011304)2.29744419
52Dysmetric saccades (HP:0000641)2.29025596
53Genetic anticipation (HP:0003743)2.27093741
54Selective tooth agenesis (HP:0001592)2.26745180
55Aplasia/hypoplasia of the humerus (HP:0006507)2.25983819
56Broad alveolar ridges (HP:0000187)2.22741917
57Abnormality of the parietal bone (HP:0002696)2.20090096
58Choanal stenosis (HP:0000452)2.18427049
59Reduced subcutaneous adipose tissue (HP:0003758)2.15956328
60Duplication of thumb phalanx (HP:0009942)2.15942855
61Abnormality of the aortic arch (HP:0012303)2.14646761
62Orthostatic hypotension (HP:0001278)2.13871710
63Increased number of teeth (HP:0011069)2.12792822
64Proximal tubulopathy (HP:0000114)2.12496387
65Abnormality of the anterior chamber (HP:0000593)2.05875863
66Abnormal hemoglobin (HP:0011902)2.05842637
67Abnormality of dentin (HP:0010299)2.05813292
68Transposition of the great arteries (HP:0001669)2.05774258
69Abnormal connection of the cardiac segments (HP:0011545)2.05774258
70Abnormal ventriculo-arterial connection (HP:0011563)2.05774258
71Abnormality of the calcaneus (HP:0008364)2.04682187
72Alopecia of scalp (HP:0002293)2.04416652
73Anophthalmia (HP:0000528)2.03980583
74Myopathic facies (HP:0002058)2.02178625
75Ankle contracture (HP:0006466)2.01746764
76Abnormality of the intrinsic pathway (HP:0010989)2.01704185
77Hypoplasia of the iris (HP:0007676)2.01430911
78Trigonocephaly (HP:0000243)1.99592008
79Generalized amyotrophy (HP:0003700)1.99282157
80Wrist flexion contracture (HP:0001239)1.98261880
81Long palpebral fissure (HP:0000637)1.97466950
82Bowed forearm bones (HP:0003956)1.96860442
83Bowing of the arm (HP:0006488)1.96860442
84Mesomelia (HP:0003027)1.96777394
85Soft skin (HP:0000977)1.96138096
86Congenital hip dislocation (HP:0001374)1.95465565
87Hyperacusis (HP:0010780)1.94269051
88Mesangial abnormality (HP:0001966)1.93589587
89Thin bony cortex (HP:0002753)1.93557290
90External ophthalmoplegia (HP:0000544)1.93354079
91Buphthalmos (HP:0000557)1.92803793
92Short 5th finger (HP:0009237)1.92527952
93Birth length less than 3rd percentile (HP:0003561)1.91324430
94Vertebral compression fractures (HP:0002953)1.90541680
95Biconcave vertebral bodies (HP:0004586)1.88505951
96Congenital glaucoma (HP:0001087)1.86461079
97Broad phalanges of the hand (HP:0009768)1.85486231
98Atelectasis (HP:0100750)1.84035899
99Aplasia/Hypoplasia of the patella (HP:0006498)1.83459695
100Trismus (HP:0000211)1.82961596
101Decreased lacrimation (HP:0000633)1.82676258
102Atrophic scars (HP:0001075)1.82442818
103Aplasia of the musculature (HP:0100854)1.81944189
104Hypoplastic heart (HP:0001961)1.81520408
105Abnormality of the peritoneum (HP:0002585)1.81486031
106Abnormal number of incisors (HP:0011064)1.80842881
107Lower limb asymmetry (HP:0100559)1.79883894
108Peritonitis (HP:0002586)1.79416922
109Chromosomal breakage induced by crosslinking agents (HP:0003221)1.79270472
110Broad finger (HP:0001500)1.79196670
111Aortic dissection (HP:0002647)1.78910336
112Broad long bones (HP:0005622)1.78547375
113Aplasia/Hypoplasia of the 5th finger (HP:0006262)1.78444862
114Patellar aplasia (HP:0006443)1.77806110
115Hydroureter (HP:0000072)1.77750118
116Broad palm (HP:0001169)1.77564793
117Aplasia/Hypoplasia of the pubic bone (HP:0009104)1.77431884
118Preaxial foot polydactyly (HP:0001841)1.77322085
119Increased connective tissue (HP:0009025)1.77059640
120Bladder diverticulum (HP:0000015)1.76819904
121Down-sloping shoulders (HP:0200021)1.76487137
122Chromsome breakage (HP:0040012)1.75986677
123Abnormality of the proximal phalanges of the hand (HP:0009834)1.75772695
124Broad phalanx (HP:0006009)1.75730110
125Blue sclerae (HP:0000592)1.75651845
126Vertebral fusion (HP:0002948)1.75253735
127Elbow flexion contracture (HP:0002987)1.75079627
128Ulnar deviation of the wrist (HP:0003049)1.74884076
129Abnormality of the labia minora (HP:0012880)1.73055412
130Sparse lateral eyebrow (HP:0005338)1.72936799
131Abnormal activity of mitochondrial respiratory chain (HP:0011922)1.72641920
132Decreased activity of mitochondrial respiratory chain (HP:0008972)1.72641920
133Hepatoblastoma (HP:0002884)1.72500468
134Pancreatic islet-cell hyperplasia (HP:0004510)1.72253299
135Broad face (HP:0000283)1.71943283
136Mildly elevated creatine phosphokinase (HP:0008180)1.71199461
137Redundant skin (HP:0001582)1.70717963
138Rectal prolapse (HP:0002035)1.70596350
139Joint laxity (HP:0001388)1.70537952
140Narrow nasal bridge (HP:0000446)1.69663785
141Unilateral renal agenesis (HP:0000122)1.68682088
142Genu recurvatum (HP:0002816)1.68494093
143Truncus arteriosus (HP:0001660)1.68253957
144Premature skin wrinkling (HP:0100678)1.68220871
145Type 1 muscle fiber predominance (HP:0003803)1.66951032
146Aortic aneurysm (HP:0004942)1.66584666
147Squamous cell carcinoma (HP:0002860)1.65823093
148Intestinal atresia (HP:0011100)1.65692252
149Aplasia/Hypoplasia of the vertebrae (HP:0008515)1.65666911
150Vertebral hypoplasia (HP:0008417)1.65666911
151Hypoplastic left heart (HP:0004383)1.65591654
152Aqueductal stenosis (HP:0002410)1.64733033
153Glucose intolerance (HP:0000833)1.64298808
154Slender long bone (HP:0003100)1.64129108
155Congenital malformation of the right heart (HP:0011723)1.63451288
156Double outlet right ventricle (HP:0001719)1.63451288
157Supernumerary ribs (HP:0005815)1.62720862
158Spinal cord lesions (HP:0100561)1.61443123
159Syringomyelia (HP:0003396)1.61443123
160Morphological abnormality of the middle ear (HP:0008609)1.61367651
161Follicular hyperkeratosis (HP:0007502)1.61006747
162Bifid scrotum (HP:0000048)1.60201878
163Bulbar palsy (HP:0001283)1.59829164
164Rough bone trabeculation (HP:0100670)1.59513715
165Poikiloderma (HP:0001029)1.59015823
166Round ear (HP:0100830)1.59011514
167Hyperextensible skin (HP:0000974)1.58157280
168Capillary hemangiomas (HP:0005306)1.57092684
169Duplicated collecting system (HP:0000081)1.56728070
170Abnormality of the renal collecting system (HP:0004742)1.56668945
171Bifid uvula (HP:0000193)1.56468853
172Myotonia (HP:0002486)1.56063625
173Spinal rigidity (HP:0003306)1.55520376
174Absent radius (HP:0003974)1.55215408
175Hamartoma (HP:0010566)1.54469847
176Deviation of the hallux (HP:0010051)1.54326724
177Hypoplastic ischia (HP:0003175)1.54154282
178Fragile skin (HP:0001030)1.54034443
179Hemivertebrae (HP:0002937)1.53977970

Predicted kinase interactions (KEA)

RankGene SetZ-score
1DDR25.28845863
2ICK4.75376809
3LATS23.51686036
4PDGFRA3.17606485
5MAP3K63.07309844
6LATS12.62477095
7NME22.62171298
8STK162.57840230
9SMG12.50813153
10PRKD32.41823562
11TRIB32.39287328
12BMX2.30100120
13MAP3K112.27903405
14MAPK152.17954877
15TYRO32.12766502
16GRK12.11064379
17IRAK32.10120932
18FGR2.06406079
19MST1R1.94014003
20LIMK11.90017109
21EPHB21.89807244
22MATK1.88458361
23ARAF1.83563061
24VRK21.79463093
25SIK11.76591419
26DYRK1B1.73015552
27BUB11.70337537
28UHMK11.69654072
29TAF11.65300959
30PRKD21.55674439
31MAPKAPK31.53365153
32DAPK11.53218059
33PINK11.51378820
34SIK21.50223690
35EPHA21.48028837
36PHKG11.44280366
37PHKG21.44280366
38CDK61.42121961
39TTN1.40842087
40EIF2AK11.36033808
41CAMK1D1.32931671
42EEF2K1.32662722
43ERBB31.31381001
44DYRK31.30814887
45CDK71.29700225
46MET1.28152189
47PAK21.23827870
48MTOR1.13316569
49FGFR11.12834171
50MAP3K101.10474144
51YES11.06656846
52PAK41.04447633
53RIPK11.00914358
54DYRK21.00235883
55GSK3A0.97520596
56BRSK10.96746470
57TRPM70.95156086
58FER0.93608126
59CDC42BPA0.92098797
60FGFR20.91264735
61CSK0.89818080
62CDK120.88827997
63CAMK1G0.88184961
64TESK20.87493533
65STK30.85702747
66MKNK10.85064009
67PIM20.82985876
68CDK80.82314013
69PTK20.81523018
70MAP3K90.78682456
71ILK0.77926607
72CHEK20.77713858
73TLK10.77437709
74NME10.71356771
75PDGFRB0.69111511
76SIK30.68748132
77PLK10.68627142
78RPS6KL10.67375255
79RPS6KC10.67375255
80TAOK20.64893833
81MELK0.64648001
82MKNK20.63632861
83ABL20.63075420
84MAPK110.61922810
85PDK20.61082135
86PRKAA10.60322255
87PDPK10.59777800
88PNCK0.59472641
89CSNK1G10.58877066
90CDK140.57685758
91TESK10.57370951
92PRKCI0.57351084
93AKT30.54031547
94NEK10.53261373
95RPS6KA20.53093249
96PAK30.52980262
97MARK10.52654245
98MAP3K130.51744280
99CDK150.51025836
100RPS6KA60.49321079
101BRAF0.49244788
102NTRK10.48060033
103PRKD10.48026303
104CDK11A0.46274426
105PAK60.45606831
106CDK180.45172891
107TAOK10.45036967
108PRKAA20.44711158
109MOS0.44238871
110INSR0.43825030
111RPS6KA10.43621801
112ALK0.43340748
113PTK60.42464114
114CCNB10.42388942
115SRPK10.41268905
116MAPKAPK50.40420494
117AURKB0.40068569
118SCYL20.39783564
119CHEK10.39142491
120AKT20.39059899
121CDK20.39006247
122MAPK100.38990410
123CSNK1A1L0.37163717
124CDK40.36723464
125CAMK2G0.36617499
126MARK20.36600953
127MAPK10.35676452
128MAPKAPK20.35431651
129CDK10.35377440
130CAMKK10.35041235
131CSNK1E0.34442473
132AURKA0.34284045
133CSNK2A10.34148674
134CSNK1G30.33909030
135NEK20.33420137
136MAP2K10.32658990
137PKN20.32176213
138TTK0.32123863
139CDK90.31996928
140MAPK90.31909998
141RPS6KB20.31295520
142DMPK0.30845843
143PAK10.30743737
144ATR0.30417543
145LRRK20.30336427
146WNK40.30278676
147PRPF4B0.29216940
148LMTK20.29100682
149MAP2K70.23639416

Predicted pathways (KEGG)

RankGene SetZ-score
1Fatty acid biosynthesis_Homo sapiens_hsa000614.29298678
2Hedgehog signaling pathway_Homo sapiens_hsa043403.26302120
3Basal cell carcinoma_Homo sapiens_hsa052173.11586763
4Hippo signaling pathway_Homo sapiens_hsa043902.95885416
5Adherens junction_Homo sapiens_hsa045202.28954280
6Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001302.25551641
7Homologous recombination_Homo sapiens_hsa034402.20598518
8TGF-beta signaling pathway_Homo sapiens_hsa043502.14963841
9Base excision repair_Homo sapiens_hsa034102.13387047
10Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006042.12216556
11One carbon pool by folate_Homo sapiens_hsa006702.10972534
12Mismatch repair_Homo sapiens_hsa034301.94564182
132-Oxocarboxylic acid metabolism_Homo sapiens_hsa012101.94484127
14Fatty acid metabolism_Homo sapiens_hsa012121.93108105
15Pyrimidine metabolism_Homo sapiens_hsa002401.90840161
16Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa005201.89565123
17Fructose and mannose metabolism_Homo sapiens_hsa000511.81662540
18mRNA surveillance pathway_Homo sapiens_hsa030151.80945325
19Wnt signaling pathway_Homo sapiens_hsa043101.78927027
20Spliceosome_Homo sapiens_hsa030401.76363736
21mTOR signaling pathway_Homo sapiens_hsa041501.75542989
22Proteoglycans in cancer_Homo sapiens_hsa052051.67211926
23Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa045501.61380676
24Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005331.58935841
25Focal adhesion_Homo sapiens_hsa045101.56547960
26Notch signaling pathway_Homo sapiens_hsa043301.54177200
27Sulfur metabolism_Homo sapiens_hsa009201.53351015
28Bladder cancer_Homo sapiens_hsa052191.53036034
29Circadian rhythm_Homo sapiens_hsa047101.51334637
30MicroRNAs in cancer_Homo sapiens_hsa052061.50622002
31Colorectal cancer_Homo sapiens_hsa052101.49994796
32RNA transport_Homo sapiens_hsa030131.44383050
33Steroid biosynthesis_Homo sapiens_hsa001001.42534257
34Bacterial invasion of epithelial cells_Homo sapiens_hsa051001.42351058
35RNA polymerase_Homo sapiens_hsa030201.41626924
36Cyanoamino acid metabolism_Homo sapiens_hsa004601.39806606
37Ubiquitin mediated proteolysis_Homo sapiens_hsa041201.38172977
38Cell cycle_Homo sapiens_hsa041101.36393914
39AMPK signaling pathway_Homo sapiens_hsa041521.35831499
40Tight junction_Homo sapiens_hsa045301.34147919
41Oocyte meiosis_Homo sapiens_hsa041141.30960387
42ECM-receptor interaction_Homo sapiens_hsa045121.30452779
43Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate_Homo sapiens_hsa005321.27926142
44Axon guidance_Homo sapiens_hsa043601.27454273
45Insulin signaling pathway_Homo sapiens_hsa049101.24629762
46Small cell lung cancer_Homo sapiens_hsa052221.22511716
47Chronic myeloid leukemia_Homo sapiens_hsa052201.21887585
48Longevity regulating pathway - mammal_Homo sapiens_hsa042111.21573923
49Thyroid cancer_Homo sapiens_hsa052161.20002743
50Citrate cycle (TCA cycle)_Homo sapiens_hsa000201.19657428
51Lysine degradation_Homo sapiens_hsa003101.17220052
52Nucleotide excision repair_Homo sapiens_hsa034201.15042728
53Other glycan degradation_Homo sapiens_hsa005111.13854036
54Gap junction_Homo sapiens_hsa045401.10913154
55Regulation of actin cytoskeleton_Homo sapiens_hsa048101.07902240
56DNA replication_Homo sapiens_hsa030301.07695271
57Viral myocarditis_Homo sapiens_hsa054161.07615386
58Regulation of lipolysis in adipocytes_Homo sapiens_hsa049231.07164519
59Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa009701.05614981
60Pathways in cancer_Homo sapiens_hsa052001.05040332
61Transcriptional misregulation in cancer_Homo sapiens_hsa052021.05013202
62Folate biosynthesis_Homo sapiens_hsa007901.04626882
63p53 signaling pathway_Homo sapiens_hsa041151.04029960
64Terpenoid backbone biosynthesis_Homo sapiens_hsa009001.03736269
65PI3K-Akt signaling pathway_Homo sapiens_hsa041511.01846979
66Endometrial cancer_Homo sapiens_hsa052131.00706754
67Propanoate metabolism_Homo sapiens_hsa006400.96349736
68Taurine and hypotaurine metabolism_Homo sapiens_hsa004300.95919616
69Central carbon metabolism in cancer_Homo sapiens_hsa052300.94826329
70Melanoma_Homo sapiens_hsa052180.94413359
71Shigellosis_Homo sapiens_hsa051310.91292431
72Melanogenesis_Homo sapiens_hsa049160.90509727
73VEGF signaling pathway_Homo sapiens_hsa043700.88768099
74Arrhythmogenic right ventricular cardiomyopathy (ARVC)_Homo sapiens_hsa054120.88565661
75Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005630.87305540
76Galactose metabolism_Homo sapiens_hsa000520.86479306
77Other types of O-glycan biosynthesis_Homo sapiens_hsa005140.85398332
78Vasopressin-regulated water reabsorption_Homo sapiens_hsa049620.83406184
79Rap1 signaling pathway_Homo sapiens_hsa040150.81768282
80Maturity onset diabetes of the young_Homo sapiens_hsa049500.80794360
81ErbB signaling pathway_Homo sapiens_hsa040120.80196221
82Purine metabolism_Homo sapiens_hsa002300.79652772
83N-Glycan biosynthesis_Homo sapiens_hsa005100.79363390
84Sulfur relay system_Homo sapiens_hsa041220.78474889
85Basal transcription factors_Homo sapiens_hsa030220.76625233
86Prostate cancer_Homo sapiens_hsa052150.76409018
87AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa049330.75380284
88Progesterone-mediated oocyte maturation_Homo sapiens_hsa049140.74983677
89Cholinergic synapse_Homo sapiens_hsa047250.74376512
90HTLV-I infection_Homo sapiens_hsa051660.73077920
91Drug metabolism - other enzymes_Homo sapiens_hsa009830.72646273
92Pancreatic cancer_Homo sapiens_hsa052120.69290256
93Pyruvate metabolism_Homo sapiens_hsa006200.67667251
94Synthesis and degradation of ketone bodies_Homo sapiens_hsa000720.67635766
95Longevity regulating pathway - multiple species_Homo sapiens_hsa042130.67388143
96Taste transduction_Homo sapiens_hsa047420.66753390
97Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa005340.66080432
98Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa049610.64847484
99Arginine and proline metabolism_Homo sapiens_hsa003300.62365571
100Vibrio cholerae infection_Homo sapiens_hsa051100.62352166
101Glutathione metabolism_Homo sapiens_hsa004800.60892684
102Biosynthesis of amino acids_Homo sapiens_hsa012300.60497251
103Huntingtons disease_Homo sapiens_hsa050160.57429487
104Glycosaminoglycan degradation_Homo sapiens_hsa005310.56737280
105Thyroid hormone signaling pathway_Homo sapiens_hsa049190.56066754
106Viral carcinogenesis_Homo sapiens_hsa052030.55259042
107Choline metabolism in cancer_Homo sapiens_hsa052310.55123708
108Cysteine and methionine metabolism_Homo sapiens_hsa002700.54655518
109Glioma_Homo sapiens_hsa052140.52587329
110Renal cell carcinoma_Homo sapiens_hsa052110.51652545
111Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030080.51318148
112Ovarian steroidogenesis_Homo sapiens_hsa049130.49275200
113Endocytosis_Homo sapiens_hsa041440.49186722
114Neurotrophin signaling pathway_Homo sapiens_hsa047220.49158745
115Hypertrophic cardiomyopathy (HCM)_Homo sapiens_hsa054100.48884372
116Glucagon signaling pathway_Homo sapiens_hsa049220.48470759
117Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049320.48420860
118Cytosolic DNA-sensing pathway_Homo sapiens_hsa046230.47494707
119Dilated cardiomyopathy_Homo sapiens_hsa054140.47010030
120Prion diseases_Homo sapiens_hsa050200.46111318
121MAPK signaling pathway_Homo sapiens_hsa040100.44985997
122Amoebiasis_Homo sapiens_hsa051460.44494694
123PPAR signaling pathway_Homo sapiens_hsa033200.44459077
124Valine, leucine and isoleucine degradation_Homo sapiens_hsa002800.44409750
125Pentose phosphate pathway_Homo sapiens_hsa000300.41944228
126Estrogen signaling pathway_Homo sapiens_hsa049150.41346010
127Vitamin B6 metabolism_Homo sapiens_hsa007500.41241056
128Ribosome_Homo sapiens_hsa030100.40328634
129Metabolic pathways_Homo sapiens_hsa011000.39675170
130Vitamin digestion and absorption_Homo sapiens_hsa049770.39560703
131Butanoate metabolism_Homo sapiens_hsa006500.38956014
132Fanconi anemia pathway_Homo sapiens_hsa034600.38813053
133Protein digestion and absorption_Homo sapiens_hsa049740.38730686
134Protein processing in endoplasmic reticulum_Homo sapiens_hsa041410.38500218
135Phospholipase D signaling pathway_Homo sapiens_hsa040720.38494436
136Acute myeloid leukemia_Homo sapiens_hsa052210.38038302
137Insulin resistance_Homo sapiens_hsa049310.37606105
138Non-small cell lung cancer_Homo sapiens_hsa052230.34938819
139GnRH signaling pathway_Homo sapiens_hsa049120.34503877

Most similar genes based on co-expression Upload to Enrichr

Tissue Expression Export image »

Cell Line Expression Export image »