HOXC6

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: This gene belongs to the homeobox family, members of which encode a highly conserved family of transcription factors that play an important role in morphogenesis in all multicellular organisms. Mammals possess four similar homeobox gene clusters, HOXA, HOXB, HOXC and HOXD, which are located on different chromosomes and consist of 9 to 11 genes arranged in tandem. This gene, HOXC6, is one of several HOXC genes located in a cluster on chromosome 12. Three genes, HOXC5, HOXC4 and HOXC6, share a 5' non-coding exon. Transcripts may include the shared exon spliced to the gene-specific exons, or they may include only the gene-specific exons. Alternatively spliced transcript variants encoding different isoforms have been identified for HOXC6. Transcript variant two includes the shared exon, and transcript variant one includes only gene-specific exons. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1glomerular basement membrane development (GO:0032836)7.03282938
2glomerular visceral epithelial cell development (GO:0072015)6.70036458
3outer ear morphogenesis (GO:0042473)5.87845361
4mesenchymal-epithelial cell signaling (GO:0060638)5.78261818
5glomerular epithelial cell development (GO:0072310)5.78184024
6chondrocyte proliferation (GO:0035988)5.34461544
7metanephric mesenchyme development (GO:0072075)5.06602857
8protein heterotrimerization (GO:0070208)4.95702628
9kidney mesenchyme development (GO:0072074)4.94865810
10proximal/distal pattern formation (GO:0009954)4.88464062
11organ induction (GO:0001759)4.83265988
12collagen fibril organization (GO:0030199)4.77670813
13bone trabecula formation (GO:0060346)4.55706114
14positive regulation of cyclin-dependent protein serine/threonine kinase activity involved in G1/S tr4.48252623
15neuron projection extension involved in neuron projection guidance (GO:1902284)4.37424600
16axon extension involved in axon guidance (GO:0048846)4.37424600
17prostate epithelial cord arborization involved in prostate glandular acinus morphogenesis (GO:0060524.34911065
18planar cell polarity pathway involved in neural tube closure (GO:0090179)4.23308857
19wound healing, spreading of epidermal cells (GO:0035313)4.22592231
20paraxial mesoderm development (GO:0048339)4.21730916
21embryonic skeletal joint morphogenesis (GO:0060272)4.07167981
22cranial nerve morphogenesis (GO:0021602)4.05518620
23regulation of establishment of planar polarity involved in neural tube closure (GO:0090178)4.00599896
24positive regulation of endothelial cell apoptotic process (GO:2000353)3.85889503
25regulation of cyclin-dependent protein serine/threonine kinase activity involved in G1/S transition 3.83156217
26regulation of apoptotic process involved in morphogenesis (GO:1902337)3.81921772
27craniofacial suture morphogenesis (GO:0097094)3.76269641
28cochlea morphogenesis (GO:0090103)3.75889164
29regulation of branching involved in salivary gland morphogenesis (GO:0060693)3.73680204
30thyroid gland development (GO:0030878)3.69324550
31regulation of vascular endothelial growth factor signaling pathway (GO:1900746)3.68994982
32regulation of organ formation (GO:0003156)3.67593688
33cartilage development involved in endochondral bone morphogenesis (GO:0060351)3.67049833
34sequestering of extracellular ligand from receptor (GO:0035581)3.66423475
35mesenchymal to epithelial transition involved in metanephros morphogenesis (GO:0003337)3.61898520
36branching involved in prostate gland morphogenesis (GO:0060442)3.61870974
37outflow tract septum morphogenesis (GO:0003148)3.61801618
38wound healing, spreading of cells (GO:0044319)3.61246652
39lymph vessel development (GO:0001945)3.56732784
40glomerulus development (GO:0032835)3.52583885
41cell adhesion mediated by integrin (GO:0033627)3.46485144
42regulation of mammary gland epithelial cell proliferation (GO:0033599)3.46313934
43endodermal cell differentiation (GO:0035987)3.44683163
44cell proliferation involved in metanephros development (GO:0072203)3.44425479
45negative regulation of fatty acid transport (GO:2000192)3.39355495
46basement membrane organization (GO:0071711)3.38090894
47tooth mineralization (GO:0034505)3.35164191
48lateral sprouting from an epithelium (GO:0060601)3.34827296
49embryonic organ morphogenesis (GO:0048562)3.33695147
50collagen catabolic process (GO:0030574)3.33570995
51collagen metabolic process (GO:0032963)3.33227164
52branching involved in salivary gland morphogenesis (GO:0060445)3.30098453
53multicellular organismal macromolecule metabolic process (GO:0044259)3.29399339
54negative regulation of systemic arterial blood pressure (GO:0003085)3.28474421
55positive regulation of fatty acid oxidation (GO:0046321)3.27890242
56regulation of cardioblast proliferation (GO:0003264)3.27478237
57regulation of secondary heart field cardioblast proliferation (GO:0003266)3.27478237
58pharyngeal system development (GO:0060037)3.26382111
59hemidesmosome assembly (GO:0031581)3.25313596
60renal filtration (GO:0097205)3.25126342
61negative regulation of cell size (GO:0045792)3.24409425
62cellular response to vitamin D (GO:0071305)3.22208919
63cellular response to vitamin (GO:0071295)3.21856644
64vascular endothelial growth factor signaling pathway (GO:0038084)3.20966716
65positive regulation of cartilage development (GO:0061036)3.18325320
66metanephros development (GO:0001656)3.18129026
67regulation of branching involved in prostate gland morphogenesis (GO:0060687)3.17037009
68cell migration involved in sprouting angiogenesis (GO:0002042)3.15563872
69multicellular organismal catabolic process (GO:0044243)3.15102421
70axis elongation (GO:0003401)3.13355232
71white fat cell differentiation (GO:0050872)3.11873810
72lung-associated mesenchyme development (GO:0060484)3.10530266
73muscle cell fate commitment (GO:0042693)3.09974175
74multicellular organismal metabolic process (GO:0044236)3.09719395
75positive regulation of fatty acid beta-oxidation (GO:0032000)3.06753222
76polarized epithelial cell differentiation (GO:0030859)3.06232999
77pattern specification involved in kidney development (GO:0061004)3.05553380
78G-protein coupled receptor signaling pathway coupled to cGMP nucleotide second messenger (GO:00071993.05263959
79embryonic skeletal system morphogenesis (GO:0048704)3.03352756
80mammary gland epithelial cell differentiation (GO:0060644)3.03208568
81cellular response to interferon-alpha (GO:0035457)3.02669435
82positive regulation of blood vessel endothelial cell migration (GO:0043536)3.02467099
83developmental induction (GO:0031128)3.01333833
84mesenchyme development (GO:0060485)3.00204939
85negative regulation of chondrocyte differentiation (GO:0032331)2.99009690
86insulin-like growth factor receptor signaling pathway (GO:0048009)2.98424871
87* anterior/posterior pattern specification (GO:0009952)2.98403781
88regulation of fatty acid beta-oxidation (GO:0031998)2.97705215
89glomerular filtration (GO:0003094)2.97017305
90embryonic camera-type eye development (GO:0031076)2.96551517
91replicative senescence (GO:0090399)2.96539927
92retina vasculature morphogenesis in camera-type eye (GO:0061299)2.96365617
93hippo signaling (GO:0035329)2.95362908
94regulation of cellular response to vascular endothelial growth factor stimulus (GO:1902547)2.95345352
95mesonephros development (GO:0001823)2.94422954
96negative regulation of pathway-restricted SMAD protein phosphorylation (GO:0060394)2.93787589
97middle ear morphogenesis (GO:0042474)2.93725791
98cell migration involved in heart development (GO:0060973)2.92217661
99lymphangiogenesis (GO:0001946)2.91823663
100regulation of cartilage development (GO:0061035)2.90601053
101positive regulation of gastrulation (GO:2000543)2.89648277
102positive regulation of collagen metabolic process (GO:0010714)2.89162275
103* embryonic skeletal system development (GO:0048706)2.89028473
104cell proliferation involved in kidney development (GO:0072111)2.88576318
105cell-cell signaling involved in cell fate commitment (GO:0045168)2.87480564
106regulation of axon guidance (GO:1902667)2.86681880
107cell-substrate junction assembly (GO:0007044)2.86647699
108mesenchymal to epithelial transition (GO:0060231)2.86316238
109plasma membrane repair (GO:0001778)2.85822206
110embryonic cranial skeleton morphogenesis (GO:0048701)2.84279203
111skeletal system morphogenesis (GO:0048705)2.83535349
112regulation of axon extension involved in axon guidance (GO:0048841)2.82975431
113embryonic forelimb morphogenesis (GO:0035115)2.82608041
114regulation of mesenchymal to epithelial transition involved in metanephros morphogenesis (GO:00033392.82382844
115regulation of collagen metabolic process (GO:0010712)2.81822181
116endocardial cushion development (GO:0003197)2.79190012
117facial nerve structural organization (GO:0021612)2.77091347
118regulation of collagen biosynthetic process (GO:0032965)2.76265991
119negative regulation of axon guidance (GO:1902668)2.76137411
120mesonephric tubule development (GO:0072164)2.76137194
121aorta morphogenesis (GO:0035909)2.75073597
122positive regulation of collagen biosynthetic process (GO:0032967)2.74951473
123branching involved in ureteric bud morphogenesis (GO:0001658)2.74885492
124keratinocyte proliferation (GO:0043616)2.74790270
125coronary vasculature morphogenesis (GO:0060977)2.73840862
126mesonephric epithelium development (GO:0072163)2.73518503
127forelimb morphogenesis (GO:0035136)2.72118165
128regulation of tight junction assembly (GO:2000810)2.71403726
129negative regulation of protein localization to cell surface (GO:2000009)2.70520400
130nephron tubule formation (GO:0072079)2.68970350
131outflow tract morphogenesis (GO:0003151)2.64725878
132neuron fate specification (GO:0048665)2.63068050
133diaphragm development (GO:0060539)2.62673350
134endothelial cell chemotaxis (GO:0035767)2.61448539
135regulation of heart morphogenesis (GO:2000826)2.61331108
136uterus development (GO:0060065)2.59159995
137Wnt signaling pathway, planar cell polarity pathway (GO:0060071)2.57033250
138endothelial cell morphogenesis (GO:0001886)2.53948114
139urogenital system development (GO:0001655)2.52186089
140negative regulation of kidney development (GO:0090185)2.46238015
141prostate gland epithelium morphogenesis (GO:0060740)2.45066386
142negative regulation of BMP signaling pathway (GO:0030514)2.42834803
143regulation of establishment of planar polarity (GO:0090175)2.41865620
144regulation of mesenchymal cell apoptotic process (GO:2001053)2.41562637
145positive regulation of myotube differentiation (GO:0010831)2.41296446
146regulation of translational termination (GO:0006449)2.40249546
147negative regulation of phosphatidylinositol 3-kinase signaling (GO:0014067)2.39320995
148face morphogenesis (GO:0060325)2.38206331
149positive regulation of transcription from RNA polymerase III promoter (GO:0045945)2.38128390
150regulation of peroxisome proliferator activated receptor signaling pathway (GO:0035358)2.37672727
151snRNA transcription (GO:0009301)2.36300913
152regulation of glucose import in response to insulin stimulus (GO:2001273)2.35691638
153regulation of fatty acid oxidation (GO:0046320)2.35479074
154positive regulation of branching involved in ureteric bud morphogenesis (GO:0090190)2.35134455
155regulation of receptor binding (GO:1900120)2.34035772
156muscle organ morphogenesis (GO:0048644)2.32616776
157mammary gland development (GO:0030879)2.32370114
158UDP-N-acetylglucosamine metabolic process (GO:0006047)2.31137991
159protein retention in ER lumen (GO:0006621)2.30886109
160semaphorin-plexin signaling pathway (GO:0071526)2.30647029
161negative regulation of mesenchymal cell apoptotic process (GO:2001054)2.30578024
162endosome to melanosome transport (GO:0035646)2.30499095
163endosome to pigment granule transport (GO:0043485)2.30499095

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1TP63_17297297_ChIP-ChIP_HaCaT_Human5.66914673
2* TRIM28_21343339_ChIP-Seq_HEK293_Human4.26195141
3RARG_19884340_ChIP-ChIP_MEFs_Mouse3.67216852
4PPARG_19300518_ChIP-PET_3T3-L1_Mouse3.37042273
5TRP63_18441228_ChIP-ChIP_KERATINOCYTES_Mouse3.28953107
6PPARD_23176727_ChIP-Seq_KERATINOCYTES_Mouse3.09802989
7CLOCK_20551151_ChIP-Seq_293T_Human2.84875031
8WT1_20215353_ChIP-ChIP_NEPHRON_PROGENITOR_Mouse2.69106933
9* ESR1_22446102_ChIP-Seq_UTERUS_Mouse2.34851392
10* EZH2_18974828_ChIP-Seq_MESCs_Mouse2.30578266
11* RNF2_18974828_ChIP-Seq_MESCs_Mouse2.30578266
12* RUNX2_24764292_ChIP-Seq_MC3T3_Mouse2.30446463
13TBP_23326641_ChIP-Seq_C3H10T1-2_Mouse2.27842087
14TCF21_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human2.27721175
15* TP53_20018659_ChIP-ChIP_R1E_Mouse2.27201880
16EP300_20729851_ChIP-Seq_FORBRAIN_MIDBRAIN_LIMB_HEART_Mouse2.26763116
17* EED_16625203_ChIP-ChIP_MESCs_Mouse2.20326413
18ESR1_15608294_ChIP-ChIP_MCF-7_Human2.16833533
19* PHC1_16625203_ChIP-ChIP_MESCs_Mouse2.16183500
20CHD7_19251738_ChIP-ChIP_MESCs_Mouse2.09984402
21WT1_19549856_ChIP-ChIP_CCG9911_Human2.08468652
22ESR1_21235772_ChIP-Seq_MCF-7_Human2.00764881
23FOXM1_23109430_ChIP-Seq_U2OS_Human1.94554457
24* CDX2_19796622_ChIP-Seq_MESCs_Mouse1.92071985
25CJUN_26792858_Chip-Seq_BT549_Human1.91397693
26STAT3_22323479_ChIP-Seq_MACROPHAGE_Mouse1.89808977
27CEBPB_21427703_ChIP-Seq_3T3-L1_Mouse1.87247615
28* JARID2_20075857_ChIP-Seq_MESCs_Mouse1.85402291
29* SUZ12_18692474_ChIP-Seq_MEFs_Mouse1.84465974
30EZH2_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse1.83649442
31DACH1_20351289_ChIP-Seq_MDA-MB-231_Human1.81806817
32BRD4_25478319_ChIP-Seq_HGPS_Human1.81387430
33* SUZ12_16625203_ChIP-ChIP_MESCs_Mouse1.80736436
34CEBPD_21427703_ChIP-Seq_3T3-L1_Mouse1.80294175
35EP300_21415370_ChIP-Seq_HL-1_Mouse1.80279093
36E2F7_22180533_ChIP-Seq_HELA_Human1.79042867
37NUCKS1_24931609_ChIP-Seq_HEPATOCYTES_Mouse1.77428533
38* SUZ12_18974828_ChIP-Seq_MESCs_Mouse1.74413682
39* KLF2_18264089_ChIP-ChIP_MESCs_Mouse1.73146656
40* KLF5_18264089_ChIP-ChIP_MESCs_Mouse1.73146656
41* KLF4_18264089_ChIP-ChIP_MESCs_Mouse1.73146656
42* EZH2_27304074_Chip-Seq_ESCs_Mouse1.72153832
43ZNF263_19887448_ChIP-Seq_K562_Human1.71210227
44STAT6_21828071_ChIP-Seq_BEAS2B_Human1.70674897
45* RNF2_16625203_ChIP-ChIP_MESCs_Mouse1.70638427
46ELK3_25401928_ChIP-Seq_HUVEC_Human1.68915611
47TAF7L_23326641_ChIP-Seq_C3H10T1-2_Mouse1.67152746
48* TET1_21451524_ChIP-Seq_MESCs_Mouse1.63558847
49* CBX2_27304074_Chip-Seq_ESCs_Mouse1.63434586
50SOX9_24532713_ChIP-Seq_HFSC_Mouse1.63178133
51BP1_19119308_ChIP-ChIP_Hs578T_Human1.61995999
52* JARID2_20064375_ChIP-Seq_MESCs_Mouse1.57836600
53P300_27058665_Chip-Seq_ZR-75-30cells_Human1.57833736
54CHD1_26751641_Chip-Seq_LNCaP_Human1.53704416
55CREB1_26743006_Chip-Seq_LNCaP_Human1.51851213
56ZFP281_18757296_ChIP-ChIP_E14_Mouse1.51723978
57TP53_22127205_ChIP-Seq_IMR90_Human1.51635806
58SUZ12_18555785_ChIP-Seq_MESCs_Mouse1.49797609
59* STAT3_19079543_ChIP-ChIP_MESCs_Mouse1.49030678
60XRN2_22483619_ChIP-Seq_HELA_Human1.48576129
61RBPJ_22232070_ChIP-Seq_NCS_Mouse1.48069126
62HIF1A_21447827_ChIP-Seq_MCF-7_Human1.48068882
63CREB1_26743006_Chip-Seq_LNCaP-abl_Human1.47910108
64TP63_19390658_ChIP-ChIP_HaCaT_Human1.47847689
65HCFC1_20581084_ChIP-Seq_MESCs_Mouse1.47051375
66ESR2_21235772_ChIP-Seq_MCF-7_Human1.42056596
67HOXD13_18407260_ChIP-ChIP_DEVELOPING-LIMBS_Mouse1.41504488
68ZNF652_21678463_ChIP-ChIP_ZR75-1_Human1.40757940
69WT1_25993318_ChIP-Seq_PODOCYTE_Human1.40659254
70DMRT1_23473982_ChIP-Seq_TESTES_Mouse1.39926910
71KDM2B_26808549_Chip-Seq_SIL-ALL_Human1.39711755
72* SMAD3_18955504_ChIP-ChIP_HaCaT_Human1.39670692
73* SMAD2_18955504_ChIP-ChIP_HaCaT_Human1.39670692
74HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse1.38729283
75KDM2B_26808549_Chip-Seq_SUP-B15_Human1.36110163
76UBF1/2_26484160_Chip-Seq_HMEC-DERIVED_Human1.35675027
77* SUZ12_18692474_ChIP-Seq_MESCs_Mouse1.35492939
78* MTF2_20144788_ChIP-Seq_MESCs_Mouse1.33500987
79KLF6_26769127_Chip-Seq_PDAC-Cell_line_Human1.32398663
80SMAD4_19686287_ChIP-ChIP_HaCaT_Human1.31545135
81* CDX2_20551321_ChIP-Seq_CACO-2_Human1.31282239
82ESR1_20079471_ChIP-ChIP_T-47D_Human1.31084194
83KDM2B_26808549_Chip-Seq_K562_Human1.30928409
84AR_21909140_ChIP-Seq_LNCAP_Human1.30459358
85SMC1_22415368_ChIP-Seq_MEFs_Mouse1.29864852
86JUND_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human1.27975968
87ISL1_27105846_Chip-Seq_CPCs_Mouse1.27781475
88RUNX1_27514584_Chip-Seq_MCF-7_Human1.27406658
89NRF2_20460467_ChIP-Seq_MEFs_Mouse1.27346621
90NFE2L2_20460467_ChIP-Seq_MEFs_Mouse1.27346621
91TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat1.26923456
92RACK7_27058665_Chip-Seq_MCF-7_Human1.26861522
93GLI1_17442700_ChIP-ChIP_MESCs_Mouse1.26305839
94P68_20966046_ChIP-Seq_HELA_Human1.26128776
95MYC_18555785_ChIP-Seq_MESCs_Mouse1.25975058
96* RNF2_27304074_Chip-Seq_ESCs_Mouse1.25785367
97NANOG_18700969_ChIP-ChIP_MESCs_Mouse1.24550399
98TCF3_18467660_ChIP-ChIP_MESCs_Mouse1.23347572
99UBF1/2_26484160_Chip-Seq_HMECs_Human1.19805098
100ERG_21242973_ChIP-ChIP_JURKAT_Human1.19218814
101ZFP281_18358816_ChIP-ChIP_MESCs_Mouse1.18031433
102MYC_22102868_ChIP-Seq_BL_Human1.17873431
103JUN_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human1.17774660
104* ZFP281_27345836_Chip-Seq_ESCs_Mouse1.16978597
105MYCN_27167114_Chip-Seq_NEUROBLASTOMA_Human1.16938948
106CREB1_23762244_ChIP-Seq_HIPPOCAMPUS_Rat1.16380881
107PPAR_26484153_Chip-Seq_NCI-H1993_Human1.16098172
108SMC4_20622854_ChIP-Seq_HELA_Human1.15872721
109LXR_22292898_ChIP-Seq_THP-1_Human1.15636694
110CTCF_27219007_Chip-Seq_ERYTHROID_Human1.15449262
111KLF4_18555785_ChIP-Seq_MESCs_Mouse1.15266289
112SREBP1_19666523_ChIP-Seq_LIVER_Mouse1.15151580
113VDR_21846776_ChIP-Seq_THP-1_Human1.15117679
114TFAP2C_20629094_ChIP-Seq_MCF-7_Human1.14752496
115KLF4_19030024_ChIP-ChIP_MESCs_Mouse1.14734918
116KDM2B_26808549_Chip-Seq_DND41_Human1.14335909
117SA1_27219007_Chip-Seq_ERYTHROID_Human1.13829147
118* RING1B_27294783_Chip-Seq_NPCs_Mouse1.13090000
119SMAD3_22036565_ChIP-Seq_ESCs_Mouse1.12686105
120SMC3_22415368_ChIP-Seq_MEFs_Mouse1.12384357
121TP53_18474530_ChIP-ChIP_U2OS_Human1.11476086
122CCND1_20090754_ChIP-ChIP_RETINA_Mouse1.09367389
123KDM5A_27292631_Chip-Seq_BREAST_Human1.09089311
124P63_26484246_Chip-Seq_KERATINOCYTES_Human1.08903042
125SALL4_18804426_ChIP-ChIP_XEN_Mouse1.08437527
126* EGR1_20690147_ChIP-Seq_ERYTHROLEUKEMIA_Human1.08115081
127TBX5_21415370_ChIP-Seq_HL-1_Mouse1.08070066
128TBX20_22080862_ChIP-Seq_HEART_Mouse1.07883257
129TBX20_22328084_ChIP-Seq_HEART_Mouse1.07883257
130ZFX_18555785_ChIP-Seq_MESCs_Mouse1.07866475
131STAT3_1855785_ChIP-Seq_MESCs_Mouse1.07851412
132PKCTHETA_26484144_Chip-Seq_BREAST_Human1.07076062
133* TP53_23651856_ChIP-Seq_MEFs_Mouse1.06829421
134CREB1_20920259_ChIP-Seq_GC1-SPG_Mouse1.06569978
135ATF3_27146783_Chip-Seq_COLON_Human1.06311558
136* EZH2_27294783_Chip-Seq_ESCs_Mouse1.06147433
137MYBL1_21750041_ChIP-ChIP_SPERMATOCYTES_Mouse1.05738276
138ATF3_23680149_ChIP-Seq_GBM1-GSC_Human1.05688503
139NKX2-5_21415370_ChIP-Seq_HL-1_Mouse1.05262515
140BCL3_23251550_ChIP-Seq_MUSCLE_Mouse1.04799538
141CEBPB_24764292_ChIP-Seq_MC3T3_Mouse1.03897715
142SMAD_19615063_ChIP-ChIP_OVARY_Human1.03732467
143CEBPD_23245923_ChIP-Seq_MEFs_Mouse1.03612512
144KLF4_26769127_Chip-Seq_PDAC-Cell_line_Human1.03424492
145SOX2_20726797_ChIP-Seq_SW620_Human1.03120853
146* BMI1_23680149_ChIP-Seq_NPCS_Mouse1.02007902
147TCF4_18268006_ChIP-ChIP_LS174T_Human1.01085300
148FOXM1_26100407_CHIP-SEQ_Hek293_flp-in_Human1.00868497

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0008438_abnormal_cutaneous_collagen5.51267667
2MP0005503_abnormal_tendon_morphology5.33891853
3MP0003705_abnormal_hypodermis_morpholog3.58248405
4MP0005623_abnormal_meninges_morphology3.51304443
5MP0009780_abnormal_chondrocyte_physiolo3.37747119
6MP0010030_abnormal_orbit_morphology3.34677036
7MP0005275_abnormal_skin_tensile3.32515228
8MP0004272_abnormal_basement_membrane3.12045181
9MP0004858_abnormal_nervous_system3.07784297
10MP0009250_abnormal_appendicular_skeleto2.68049366
11MP0003385_abnormal_body_wall2.57957211
12MP0003942_abnormal_urinary_system2.51217652
13MP0005257_abnormal_intraocular_pressure2.35945163
14MP0003279_aneurysm2.19212279
15MP0009053_abnormal_anal_canal2.15545650
16MP0003283_abnormal_digestive_organ2.14370196
17MP0005508_abnormal_skeleton_morphology2.06439129
18MP0002108_abnormal_muscle_morphology2.05841357
19MP0000534_abnormal_ureter_morphology1.97029284
20MP0000733_abnormal_muscle_development1.89539753
21MP0002160_abnormal_reproductive_system1.83198879
22MP0002060_abnormal_skin_morphology1.77976008
23MP0002249_abnormal_larynx_morphology1.76902952
24MP0002932_abnormal_joint_morphology1.72928397
25MP0001299_abnormal_eye_distance/1.69042686
26MP0001958_emphysema1.63084110
27MP0000428_abnormal_craniofacial_morphol1.61881159
28MP0000049_abnormal_middle_ear1.57619144
29MP0002282_abnormal_trachea_morphology1.57314078
30MP0010368_abnormal_lymphatic_system1.54422542
31MP0003937_abnormal_limbs/digits/tail_de1.52617413
32MP0003941_abnormal_skin_development1.49073981
33MP0001879_abnormal_lymphatic_vessel1.48840666
34MP0004185_abnormal_adipocyte_glucose1.48531072
35MP0001849_ear_inflammation1.45311569
36MP0002115_abnormal_skeleton_extremities1.44480594
37MP0003566_abnormal_cell_adhesion1.43052051
38MP0000681_abnormal_thyroid_gland1.42993358
39MP0001661_extended_life_span1.39860490
40MP0000750_abnormal_muscle_regeneration1.36127245
41MP0005023_abnormal_wound_healing1.35766103
42MP0003755_abnormal_palate_morphology1.34854570
43MP0000163_abnormal_cartilage_morphology1.34081044
44MP0000003_abnormal_adipose_tissue1.31768013
45MP0002295_abnormal_pulmonary_circulatio1.31271660
46MP0000537_abnormal_urethra_morphology1.27225767
47MP0005248_abnormal_Harderian_gland1.27136173
48MP0009384_cardiac_valve_regurgitation1.26842855
49MP0002109_abnormal_limb_morphology1.26314730
50MP0000762_abnormal_tongue_morphology1.24881469
51MP0004233_abnormal_muscle_weight1.23533146
52MP0010352_gastrointestinal_tract_polyps1.23142647
53MP0003938_abnormal_ear_development1.22121538
54MP0002111_abnormal_tail_morphology1.19575867
55* MP0002114_abnormal_axial_skeleton1.19023348
56MP0002234_abnormal_pharynx_morphology1.18831208
57MP0002269_muscular_atrophy1.17652926
58MP0002896_abnormal_bone_mineralization1.17219939
59MP0003115_abnormal_respiratory_system1.17194677
60MP0001243_abnormal_dermal_layer1.16912138
61MP0000013_abnormal_adipose_tissue1.16035862
62MP0005375_adipose_tissue_phenotype1.15959016
63MP0000767_abnormal_smooth_muscle1.15566052
64MP0001348_abnormal_lacrimal_gland1.14682372
65MP0000749_muscle_degeneration1.14166369
66MP0010307_abnormal_tumor_latency1.13464108
67MP0002971_abnormal_brown_adipose1.12182017
68MP0002116_abnormal_craniofacial_bone1.12090923
69MP0005666_abnormal_adipose_tissue1.10049857
70MP0000747_muscle_weakness1.09828365
71MP0001542_abnormal_bone_strength1.09723693
72MP0000678_abnormal_parathyroid_gland1.09449637
73MP0003091_abnormal_cell_migration1.09230818
74MP0002113_abnormal_skeleton_development1.08211349
75MP0003693_abnormal_embryo_hatching1.06878688
76MP0005646_abnormal_pituitary_gland1.06803490
77MP0005670_abnormal_white_adipose1.06363433
78MP0000759_abnormal_skeletal_muscle1.05515014
79MP0003935_abnormal_craniofacial_develop1.04624821
80MP0006054_spinal_hemorrhage1.04135261
81MP0000751_myopathy1.01565521
82MP0003879_abnormal_hair_cell1.00771958
83MP0003959_abnormal_lean_body1.00692647
84MP0002233_abnormal_nose_morphology0.99094432
85MP0005076_abnormal_cell_differentiation0.97671637
86MP0000432_abnormal_head_morphology0.96943502
87MP0002697_abnormal_eye_size0.96208519
88MP0003122_maternal_imprinting0.95747180
89MP0005197_abnormal_uvea_morphology0.95170479
90MP0003315_abnormal_perineum_morphology0.94787997
91MP0002177_abnormal_outer_ear0.94691185
92MP0004134_abnormal_chest_morphology0.93670185
93MP0003123_paternal_imprinting0.91809327
94MP0008961_abnormal_basal_metabolism0.91110521
95MP0002089_abnormal_postnatal_growth/wei0.90691969
96MP0005369_muscle_phenotype0.90612265
97MP0001340_abnormal_eyelid_morphology0.89030748
98MP0001346_abnormal_lacrimal_gland0.88667995
99MP0005171_absent_coat_pigmentation0.88434903
100MP0002135_abnormal_kidney_morphology0.87555750
101MP0005390_skeleton_phenotype0.85841005
102* MP0000627_abnormal_mammary_gland0.84956169
103MP0001614_abnormal_blood_vessel0.82316609
104MP0004130_abnormal_muscle_cell0.78392786
105MP0003567_abnormal_fetal_cardiomyocyte0.78374690
106MP0000566_synostosis0.77485930
107MP0003950_abnormal_plasma_membrane0.77278031
108MP0002925_abnormal_cardiovascular_devel0.75955518
109MP0005367_renal/urinary_system_phenotyp0.75143424
110MP0000516_abnormal_urinary_system0.75143424
111MP0008932_abnormal_embryonic_tissue0.73579560
112* MP0003936_abnormal_reproductive_system0.73469531
113MP0002128_abnormal_blood_circulation0.73319329
114MP0000467_abnormal_esophagus_morphology0.72477499
115MP0002877_abnormal_melanocyte_morpholog0.72388291
116MP0004197_abnormal_fetal_growth/weight/0.72072994
117MP0002168_other_aberrant_phenotype0.71663736
118MP0004087_abnormal_muscle_fiber0.71227556
119MP0005389_reproductive_system_phenotype0.69658798
120MP0002098_abnormal_vibrissa_morphology0.69607719
121MP0001177_atelectasis0.69278702
122MP0002092_abnormal_eye_morphology0.68947392
123MP0001756_abnormal_urination0.68000236
124MP0002970_abnormal_white_adipose0.67593271
125MP0004145_abnormal_muscle_electrophysio0.67566420
126* MP0001881_abnormal_mammary_gland0.67391460
127MP0001270_distended_abdomen0.66919828
128MP0005193_abnormal_anterior_eye0.66684359
129MP0003111_abnormal_nucleus_morphology0.66322038
130MP0002085_abnormal_embryonic_tissue0.65209880

Predicted human phenotypes

RankGene SetZ-score
1Premature rupture of membranes (HP:0001788)6.09499324
2Protrusio acetabuli (HP:0003179)5.37541563
3Shallow orbits (HP:0000586)4.91026019
4Broad metatarsal (HP:0001783)4.47015201
5Peritonitis (HP:0002586)3.85807182
6Coronal craniosynostosis (HP:0004440)3.70610605
7Hyperacusis (HP:0010780)3.61334901
8Ankle contracture (HP:0006466)3.56579486
9Atrophic scars (HP:0001075)3.38915492
10Aplasia/Hypoplasia of the 4th metacarpal (HP:0010042)3.35855454
11Short 4th metacarpal (HP:0010044)3.35855454
12Mesangial abnormality (HP:0001966)3.33183114
13Aortic dissection (HP:0002647)3.30829196
14Sparse lateral eyebrow (HP:0005338)3.29505076
15Soft skin (HP:0000977)3.27443968
16Down-sloping shoulders (HP:0200021)3.10110967
17Fragile skin (HP:0001030)2.99433233
18Type 1 muscle fiber predominance (HP:0003803)2.96887585
19Bladder diverticulum (HP:0000015)2.92796044
20Abnormality of the parietal bone (HP:0002696)2.90773452
21Cerebral aneurysm (HP:0004944)2.88183268
22Morphological abnormality of the middle ear (HP:0008609)2.86195768
23Aplasia/Hypoplasia of the 1st metacarpal (HP:0010026)2.82534053
24Short 1st metacarpal (HP:0010034)2.82534053
25Abnormality of dentin (HP:0010299)2.78573267
26Abnormality of the 4th metacarpal (HP:0010012)2.77133844
27Turricephaly (HP:0000262)2.76916463
28Focal segmental glomerulosclerosis (HP:0000097)2.76528810
29Enlarged penis (HP:0000040)2.75822600
30Abnormality of the phalanges of the hallux (HP:0010057)2.74462758
31Neonatal short-limb short stature (HP:0008921)2.64185888
32Abnormality of the peritoneum (HP:0002585)2.59874178
33Lip pit (HP:0100267)2.59077952
34Broad toe (HP:0001837)2.57386391
35Reduced subcutaneous adipose tissue (HP:0003758)2.49991284
36Mesomelia (HP:0003027)2.49046797
37Aortic aneurysm (HP:0004942)2.47498152
38Abnormality of the 1st metacarpal (HP:0010009)2.45278274
39Renal duplication (HP:0000075)2.43634187
40Spinal rigidity (HP:0003306)2.40678339
41Genu recurvatum (HP:0002816)2.39317200
42Increased connective tissue (HP:0009025)2.37847241
43Ulnar bowing (HP:0003031)2.37049216
44Septate vagina (HP:0001153)2.36882359
45Broad hallux (HP:0010055)2.35992494
46Lymphangioma (HP:0100764)2.35447706
47Chromsome breakage (HP:0040012)2.34703620
48Midline defect of the nose (HP:0004122)2.34366598
49Wrist flexion contracture (HP:0001239)2.32409107
50Aplasia involving bones of the extremities (HP:0009825)2.32386919
51Aplasia involving bones of the upper limbs (HP:0009823)2.32386919
52Aplasia of the phalanges of the hand (HP:0009802)2.32386919
53Follicular hyperkeratosis (HP:0007502)2.30572476
54Renovascular hypertension (HP:0100817)2.29486181
55Blue sclerae (HP:0000592)2.28246608
56Dilatation of the ascending aorta (HP:0005111)2.26254497
57Deviation of the hallux (HP:0010051)2.24307540
58Decreased subcutaneous fat (HP:0001002)2.23621091
59Hip contracture (HP:0003273)2.23264017
60Chromosomal breakage induced by crosslinking agents (HP:0003221)2.21056647
61Abnormality of the distal phalanges of the toes (HP:0010182)2.20999705
62Cervical subluxation (HP:0003308)2.20483138
63Hyperuricemia (HP:0002149)2.17153281
64Increased purine levels (HP:0004368)2.17153281
65Mitral valve prolapse (HP:0001634)2.17005927
66Knee flexion contracture (HP:0006380)2.15919883
67Microretrognathia (HP:0000308)2.15459000
68Syringomyelia (HP:0003396)2.14565246
69Spinal cord lesions (HP:0100561)2.14565246
70Exostoses (HP:0100777)2.13173233
71Limited hip movement (HP:0008800)2.12413347
72Calcaneovalgus deformity (HP:0001848)2.11220921
73Biconcave vertebral bodies (HP:0004586)2.10746493
74Hyperextensible skin (HP:0000974)2.09351679
75Cardiovascular calcification (HP:0011915)2.07495791
76Wide anterior fontanel (HP:0000260)2.06442869
77Pterygium (HP:0001059)2.06326453
78Flat cornea (HP:0007720)2.05827380
79Aplasia of the musculature (HP:0100854)2.03500032
80Wormian bones (HP:0002645)2.03487047
81Infantile muscular hypotonia (HP:0008947)2.03309411
82Camptodactyly of toe (HP:0001836)2.02753467
83Overriding aorta (HP:0002623)2.02435222
84Broad face (HP:0000283)2.02293236
85Round ear (HP:0100830)2.02119378
86Trigonocephaly (HP:0000243)2.02091211
87Abnormality of subcutaneous fat tissue (HP:0001001)2.01199323
88Thin bony cortex (HP:0002753)2.01162950
89Glomerulosclerosis (HP:0000096)1.99287100
90Dysmetric saccades (HP:0000641)1.98337814
91Muscle fiber splitting (HP:0003555)1.97862113
92Chin dimple (HP:0010751)1.97520028
93Deformed tarsal bones (HP:0008119)1.97199705
94Redundant skin (HP:0001582)1.96666212
95Abnormal ossification of hand bones (HP:0005921)1.96647329
96Unilateral renal agenesis (HP:0000122)1.96518262
97Mildly elevated creatine phosphokinase (HP:0008180)1.96409253
98Partial duplication of the phalanx of hand (HP:0009999)1.96236339
99Bowed forearm bones (HP:0003956)1.95076648
100Bowing of the arm (HP:0006488)1.95076648
101Venous abnormality (HP:0002624)1.94069139
102Elbow flexion contracture (HP:0002987)1.93190872
103Scapular winging (HP:0003691)1.93004211
104Venous insufficiency (HP:0005293)1.92545277
105Hallux valgus (HP:0001822)1.91183610
106Premature skin wrinkling (HP:0100678)1.91151735
107Short phalanx of the thumb (HP:0009660)1.91059281
108Elfin facies (HP:0004428)1.90837814
109Myopathic facies (HP:0002058)1.90651217
110Buphthalmos (HP:0000557)1.90413683
111Vertebral compression fractures (HP:0002953)1.90343738
112Ulnar deviation of the wrist (HP:0003049)1.89667314
113Nemaline bodies (HP:0003798)1.89546351
114Bowel diverticulosis (HP:0005222)1.87304221
115Bell-shaped thorax (HP:0001591)1.87303605
116Abnormal finger flexion creases (HP:0006143)1.86020943
117Muscle fiber inclusion bodies (HP:0100299)1.85863301
118Muscle fiber cytoplasmatic inclusion bodies (HP:0100303)1.85017791
119Hypoalbuminemia (HP:0003073)1.83959644
120Abnormal albumin level (HP:0012116)1.83959644
121Persistence of primary teeth (HP:0006335)1.81603612
122Abnormality of the middle phalanges of the toes (HP:0010183)1.80777869
123Abnormality of the carotid arteries (HP:0005344)1.79625449
124Absent phalangeal crease (HP:0006109)1.78393429
125Ectopia lentis (HP:0001083)1.78243241
126Testicular atrophy (HP:0000029)1.78062987
127Slender build (HP:0001533)1.77749452
128Abnormality of the distal phalanx of the thumb (HP:0009617)1.77118547
129Upper limb amyotrophy (HP:0009129)1.76871772
130Distal upper limb amyotrophy (HP:0007149)1.76871772
131Neoplasm of the heart (HP:0100544)1.76711920
132Tarsal synostosis (HP:0008368)1.75660584
133Concave nail (HP:0001598)1.74917221
134Increased variability in muscle fiber diameter (HP:0003557)1.74902920
135Achilles tendon contracture (HP:0001771)1.74844011
136Dislocated radial head (HP:0003083)1.74589970
137Recurrent corneal erosions (HP:0000495)1.74362332
138Abnormality of the calcaneus (HP:0008364)1.73976084
139Joint laxity (HP:0001388)1.73975576
140Hypoventilation (HP:0002791)1.73883036
141Fragile nails (HP:0001808)1.73649318
142Progressive muscle weakness (HP:0003323)1.72897547
143Hypoplasia of the iris (HP:0007676)1.72764958
144Preaxial foot polydactyly (HP:0001841)1.71142867
145Advanced eruption of teeth (HP:0006288)1.70758125
146Abnormality of the radial head (HP:0003995)1.70606402
147Hypoplastic ischia (HP:0003175)1.70202257
148Aplasia/Hypoplasia of the patella (HP:0006498)1.69224072
149Overgrowth (HP:0001548)1.69108746
150Rectal prolapse (HP:0002035)1.68923107
151Tetany (HP:0001281)1.68786401
152Periauricular skin pits (HP:0100277)1.68785210
153Preauricular pit (HP:0004467)1.68785210
154Bronchomalacia (HP:0002780)1.68454592
155Vascular calcification (HP:0004934)1.68164181
156Vascular tortuosity (HP:0004948)1.67732979
157Trismus (HP:0000211)1.66943719
158Patellar dislocation (HP:0002999)1.66920604
159Intestinal fistula (HP:0100819)1.66119259
160Abnormal number of incisors (HP:0011064)1.65455651
161Short thumb (HP:0009778)1.64897981
162Abnormality of the acetabulum (HP:0003170)1.64745329

Predicted kinase interactions (KEA)

RankGene SetZ-score
1LATS14.68700374
2TRIB34.16512141
3EPHB23.98322252
4LATS23.78833060
5BMX3.14682494
6ERN13.08297079
7DDR22.97636351
8PDGFRA2.87385484
9SMG12.72316284
10TTN2.71553927
11CAMK1G2.54144547
12AKT32.43571093
13CAMK1D2.34910178
14WNK42.29998286
15IRAK32.12991065
16SIK12.10992664
17PAK22.05931395
18LRRK21.89018118
19PKN21.72461120
20MAPKAPK31.66010884
21NME21.56910280
22TGFBR21.56825587
23MAP3K31.54458510
24ILK1.53116079
25STK31.49105914
26PAK41.47747870
27CDK121.44850958
28RIPK11.38320608
29FGFR11.37786396
30STK38L1.35461675
31EPHA21.23200022
32PRKD21.22078370
33WNK11.21439019
34MUSK1.19109353
35NEK21.17469007
36MTOR1.17241918
37STK391.16604553
38LIMK11.13174571
39RPS6KA61.09862599
40PTK61.07136392
41PTK21.06995379
42PDGFRB1.05123664
43EEF2K1.03238858
44ROCK11.01056399
45PHKG10.99910686
46PHKG20.99910686
47PIM20.98450183
48OXSR10.98266409
49PRKCH0.97981835
50PNCK0.97526851
51ROCK20.94808947
52MAP3K100.93323166
53FER0.92862320
54RPS6KC10.92744088
55RPS6KL10.92744088
56PRKD30.90573845
57FGFR20.90068168
58CDK90.89427725
59NUAK10.88814914
60PIK3CA0.85629187
61VRK20.84740476
62MAP3K60.83680443
63PRKCI0.83222024
64NTRK10.82393951
65PDPK10.80829541
66TRPM70.80630304
67TGFBR10.79374376
68CHEK20.79107064
69MAP3K20.74190881
70MAP2K10.73874349
71TLK10.72752190
72CHUK0.72543441
73DMPK0.72471776
74AURKA0.71052729
75RPS6KB20.68706856
76MET0.67223113
77PRKD10.67062494
78PAK30.66913286
79ICK0.65880653
80CHEK10.64221453
81MAP2K30.63990670
82AKT20.63090619
83MOS0.62925877
84OBSCN0.62822803
85PTK2B0.62815102
86TAOK10.62521056
87BUB10.62005059
88FGFR40.59620626
89CDK80.56212089
90MKNK10.54804295
91RPS6KA20.52615567
92CDK70.51850226
93MST1R0.51838196
94PRKAA10.51037841
95RPS6KA40.49613581
96MAPK150.49243400
97ABL20.48941439
98MYLK0.48661364
99GRK10.48058825
100MARK20.47871778
101CDK60.47769965
102ALK0.47709193
103INSR0.47268437
104ERBB30.46537277
105GSK3A0.45782127
106NEK90.45255312
107SRC0.44449563
108PAK10.44245911
109MELK0.44084698
110PIK3CG0.43858141
111PRPF4B0.43681954
112EIF2AK10.42966560
113PKN10.42801715
114PLK20.41301913
115RET0.40886686
116IGF1R0.39757961
117ADRBK10.39105400
118MAP3K70.38999148
119MAPKAPK50.38801856
120BRAF0.38683170
121TAF10.37850244
122MAPK140.36142122
123STK380.35219123
124PRKCE0.35021266
125MAPK120.33592100
126RPS6KB10.31399351
127MAPK90.31380963
128MAPK10.31323558
129ATR0.31221218
130STK100.30772463
131DYRK1B0.30734928
132MAP3K90.30330217
133CDC70.29430351
134TAOK20.29191542
135MAP3K80.29117628
136WNK30.28892383
137PAK60.28843651
138AURKB0.28521387
139BRSK10.28396083
140BRD40.28136789
141CDC42BPA0.28114996
142CDK10.28079844
143TESK10.27177590
144MAPKAPK20.26452390
145MAPK110.24255277
146CDK140.22008036
147PRKAA20.21929933

Predicted pathways (KEGG)

RankGene SetZ-score
1ECM-receptor interaction_Homo sapiens_hsa045124.00914794
2Basal cell carcinoma_Homo sapiens_hsa052173.40741839
3Hedgehog signaling pathway_Homo sapiens_hsa043403.07353279
4Sulfur relay system_Homo sapiens_hsa041222.93819831
5Focal adhesion_Homo sapiens_hsa045102.77450871
6Proteoglycans in cancer_Homo sapiens_hsa052052.52354304
7Protein digestion and absorption_Homo sapiens_hsa049742.51816540
8Regulation of lipolysis in adipocytes_Homo sapiens_hsa049232.41934760
9Amoebiasis_Homo sapiens_hsa051462.40902512
10One carbon pool by folate_Homo sapiens_hsa006702.29024239
11Hippo signaling pathway_Homo sapiens_hsa043902.13873370
12Small cell lung cancer_Homo sapiens_hsa052222.10092399
13AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa049332.00053295
14Melanoma_Homo sapiens_hsa052181.92593149
15Arrhythmogenic right ventricular cardiomyopathy (ARVC)_Homo sapiens_hsa054121.89296407
16Bladder cancer_Homo sapiens_hsa052191.83173607
17Axon guidance_Homo sapiens_hsa043601.76357217
18PI3K-Akt signaling pathway_Homo sapiens_hsa041511.69587252
19Adherens junction_Homo sapiens_hsa045201.69284349
20Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001301.66339219
21MicroRNAs in cancer_Homo sapiens_hsa052061.64816028
22Sulfur metabolism_Homo sapiens_hsa009201.63315715
23Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa005341.59394564
24Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa045501.54893600
25Chronic myeloid leukemia_Homo sapiens_hsa052201.53178151
26TGF-beta signaling pathway_Homo sapiens_hsa043501.49655366
27Hypertrophic cardiomyopathy (HCM)_Homo sapiens_hsa054101.47685696
28Dilated cardiomyopathy_Homo sapiens_hsa054141.45614095
29Pathways in cancer_Homo sapiens_hsa052001.43573816
30Wnt signaling pathway_Homo sapiens_hsa043101.42764782
31Bacterial invasion of epithelial cells_Homo sapiens_hsa051001.38397002
32Vasopressin-regulated water reabsorption_Homo sapiens_hsa049621.38174646
33Prostate cancer_Homo sapiens_hsa052151.33220390
34Regulation of actin cytoskeleton_Homo sapiens_hsa048101.32670151
35Protein processing in endoplasmic reticulum_Homo sapiens_hsa041411.30887852
36RNA polymerase_Homo sapiens_hsa030201.28986407
37Rap1 signaling pathway_Homo sapiens_hsa040151.23837282
38Ovarian steroidogenesis_Homo sapiens_hsa049131.23054690
39Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa005201.20096866
40Tight junction_Homo sapiens_hsa045301.18855642
41Homologous recombination_Homo sapiens_hsa034401.17668803
42Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005121.17553190
43Nucleotide excision repair_Homo sapiens_hsa034201.11841669
44Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate_Homo sapiens_hsa005321.10027798
45Glioma_Homo sapiens_hsa052141.09382769
46Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa009701.09299670
47Central carbon metabolism in cancer_Homo sapiens_hsa052301.06215523
48Melanogenesis_Homo sapiens_hsa049161.04434746
49Notch signaling pathway_Homo sapiens_hsa043300.98487300
50PPAR signaling pathway_Homo sapiens_hsa033200.97925722
51Cyanoamino acid metabolism_Homo sapiens_hsa004600.97367002
52Malaria_Homo sapiens_hsa051440.96785615
53Viral myocarditis_Homo sapiens_hsa054160.96106237
54Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030080.95683614
55Pyrimidine metabolism_Homo sapiens_hsa002400.95344111
56Selenocompound metabolism_Homo sapiens_hsa004500.94225245
57Endometrial cancer_Homo sapiens_hsa052130.92773507
58Pancreatic cancer_Homo sapiens_hsa052120.92620658
59Fanconi anemia pathway_Homo sapiens_hsa034600.92133261
60Glucagon signaling pathway_Homo sapiens_hsa049220.91140788
61Fructose and mannose metabolism_Homo sapiens_hsa000510.89959036
62mTOR signaling pathway_Homo sapiens_hsa041500.88119220
63HTLV-I infection_Homo sapiens_hsa051660.87870138
64mRNA surveillance pathway_Homo sapiens_hsa030150.84685555
65Propanoate metabolism_Homo sapiens_hsa006400.83638026
66Other types of O-glycan biosynthesis_Homo sapiens_hsa005140.83059066
67Choline metabolism in cancer_Homo sapiens_hsa052310.82823739
68Longevity regulating pathway - mammal_Homo sapiens_hsa042110.82483392
69p53 signaling pathway_Homo sapiens_hsa041150.82312056
70Renal cell carcinoma_Homo sapiens_hsa052110.78296394
71AMPK signaling pathway_Homo sapiens_hsa041520.76545385
72Leukocyte transendothelial migration_Homo sapiens_hsa046700.76474495
73Non-small cell lung cancer_Homo sapiens_hsa052230.75645518
74RNA transport_Homo sapiens_hsa030130.75010252
75Vitamin B6 metabolism_Homo sapiens_hsa007500.74522754
76Lysine degradation_Homo sapiens_hsa003100.73281644
77Arginine and proline metabolism_Homo sapiens_hsa003300.72998035
78Vitamin digestion and absorption_Homo sapiens_hsa049770.72005899
79Adipocytokine signaling pathway_Homo sapiens_hsa049200.71082609
80Ras signaling pathway_Homo sapiens_hsa040140.71064831
81Renin-angiotensin system_Homo sapiens_hsa046140.69742734
82Insulin signaling pathway_Homo sapiens_hsa049100.69636639
83Platelet activation_Homo sapiens_hsa046110.68774357
84Hepatitis C_Homo sapiens_hsa051600.68579446
85Phospholipase D signaling pathway_Homo sapiens_hsa040720.67164127
86Basal transcription factors_Homo sapiens_hsa030220.66866857
87Aldosterone synthesis and secretion_Homo sapiens_hsa049250.65997292
88Toxoplasmosis_Homo sapiens_hsa051450.65946955
89Longevity regulating pathway - multiple species_Homo sapiens_hsa042130.65139149
90Acute myeloid leukemia_Homo sapiens_hsa052210.64969968
91Ubiquitin mediated proteolysis_Homo sapiens_hsa041200.63565313
92VEGF signaling pathway_Homo sapiens_hsa043700.63081750
93Dorso-ventral axis formation_Homo sapiens_hsa043200.62700998
94Thyroid cancer_Homo sapiens_hsa052160.61730881
95Prolactin signaling pathway_Homo sapiens_hsa049170.60688391
96HIF-1 signaling pathway_Homo sapiens_hsa040660.58045464
97alpha-Linolenic acid metabolism_Homo sapiens_hsa005920.57940359
98Insulin resistance_Homo sapiens_hsa049310.57558470
99Phenylalanine metabolism_Homo sapiens_hsa003600.55856104
100Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005330.54712963
101Colorectal cancer_Homo sapiens_hsa052100.54650730
102Gap junction_Homo sapiens_hsa045400.53671594
103ErbB signaling pathway_Homo sapiens_hsa040120.53174440
104Galactose metabolism_Homo sapiens_hsa000520.53110393
105Cell cycle_Homo sapiens_hsa041100.52841042
106Nitrogen metabolism_Homo sapiens_hsa009100.52391299
107Estrogen signaling pathway_Homo sapiens_hsa049150.51026174
108Transcriptional misregulation in cancer_Homo sapiens_hsa052020.50372758
109Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005630.50006039
110Adrenergic signaling in cardiomyocytes_Homo sapiens_hsa042610.49005907
111Glycosaminoglycan degradation_Homo sapiens_hsa005310.47954686
112Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa049600.47917809
113Neurotrophin signaling pathway_Homo sapiens_hsa047220.47906228
114TNF signaling pathway_Homo sapiens_hsa046680.47796127
115DNA replication_Homo sapiens_hsa030300.47613713
116GnRH signaling pathway_Homo sapiens_hsa049120.46918249
117FoxO signaling pathway_Homo sapiens_hsa040680.46369211
118Endocytosis_Homo sapiens_hsa041440.46295953
119Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa049610.45955097
120Apoptosis_Homo sapiens_hsa042100.44131773
121Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006040.43728516
122MAPK signaling pathway_Homo sapiens_hsa040100.43528937
123Fatty acid biosynthesis_Homo sapiens_hsa000610.43407786
124Arachidonic acid metabolism_Homo sapiens_hsa005900.42889076
125Citrate cycle (TCA cycle)_Homo sapiens_hsa000200.42788176
126Base excision repair_Homo sapiens_hsa034100.42268182
127Phagosome_Homo sapiens_hsa041450.42251868
128Prion diseases_Homo sapiens_hsa050200.41760120
129Purine metabolism_Homo sapiens_hsa002300.41518193
130Salmonella infection_Homo sapiens_hsa051320.40320834
131Vascular smooth muscle contraction_Homo sapiens_hsa042700.39456691
132Thyroid hormone signaling pathway_Homo sapiens_hsa049190.38928052
133Tyrosine metabolism_Homo sapiens_hsa003500.38395469
134Viral carcinogenesis_Homo sapiens_hsa052030.35178121
135Linoleic acid metabolism_Homo sapiens_hsa005910.33292427
136cAMP signaling pathway_Homo sapiens_hsa040240.33025050
137cGMP-PKG signaling pathway_Homo sapiens_hsa040220.30504802

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