HOXC8

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: This gene belongs to the homeobox family of genes. The homeobox genes encode a highly conserved family of transcription factors that play an important role in morphogenesis in all multicellular organisms. Mammals possess four similar homeobox gene clusters, HOXA, HOXB, HOXC and HOXD, which are located on different chromosomes and consist of 9 to 11 genes arranged in tandem. This gene is one of several homeobox HOXC genes located in a cluster on chromosome 12. The product of this gene may play a role in the regulation of cartilage differentiation. It could also be involved in chondrodysplasias or other cartilage disorders. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1prostate epithelial cord arborization involved in prostate glandular acinus morphogenesis (GO:0060527.54970628
2endocardial cushion development (GO:0003197)7.41095900
3negative regulation of vascular endothelial growth factor receptor signaling pathway (GO:0030948)7.01249971
4daunorubicin metabolic process (GO:0044597)6.94048101
5polyketide metabolic process (GO:0030638)6.94048101
6doxorubicin metabolic process (GO:0044598)6.94048101
7glucocorticoid receptor signaling pathway (GO:0042921)6.86121154
8protein targeting to vacuole (GO:0006623)6.79610175
9protein targeting to lysosome (GO:0006622)6.79610175
10establishment of protein localization to vacuole (GO:0072666)6.79610175
11glomerulus development (GO:0032835)6.46515551
12vagina development (GO:0060068)6.44420410
13positive regulation of developmental pigmentation (GO:0048087)6.07762795
14regulation of pigment cell differentiation (GO:0050932)5.98523455
15regulation of establishment of cell polarity (GO:2000114)5.91450779
16negative regulation of sodium ion transport (GO:0010766)5.70391168
17negative regulation of chondrocyte differentiation (GO:0032331)5.59690704
18establishment of protein localization to Golgi (GO:0072600)5.56194728
19endosome to melanosome transport (GO:0035646)5.44215924
20endosome to pigment granule transport (GO:0043485)5.44215924
21negative regulation of osteoblast proliferation (GO:0033689)5.41540016
22mesonephros development (GO:0001823)5.40837313
23corticosteroid receptor signaling pathway (GO:0031958)5.29607387
24female genitalia development (GO:0030540)5.26303422
25embryonic skeletal system development (GO:0048706)5.24929160
26uterus development (GO:0060065)5.21544359
27negative regulation of protein localization to cell surface (GO:2000009)5.10756913
28mesenchymal-epithelial cell signaling (GO:0060638)5.10148347
29snRNA transcription (GO:0009301)5.09995179
30protein localization to vacuole (GO:0072665)5.05547934
31protein localization to lysosome (GO:0061462)5.05547934
32oxidative demethylation (GO:0070989)5.00019547
33ear development (GO:0043583)4.94755166
34N-acetylneuraminate metabolic process (GO:0006054)4.90679204
35regulation of establishment or maintenance of cell polarity (GO:0032878)4.84310561
36negative regulation of blood pressure (GO:0045776)4.81104200
37negative regulation of cartilage development (GO:0061037)4.80506749
38receptor catabolic process (GO:0032801)4.68474580
39regulation of protein heterodimerization activity (GO:0043497)4.64316538
40protein targeting to Golgi (GO:0000042)4.63652965
41negative regulation of calcium ion transport into cytosol (GO:0010523)4.55808406
42sequestering of extracellular ligand from receptor (GO:0035581)4.54916448
43monoubiquitinated protein deubiquitination (GO:0035520)4.52184009
44regulation of centriole replication (GO:0046599)4.51621592
45retrograde transport, vesicle recycling within Golgi (GO:0000301)4.44695163
46post-embryonic morphogenesis (GO:0009886)4.39089022
47positive regulation of digestive system process (GO:0060456)4.35926311
48embryonic skeletal system morphogenesis (GO:0048704)4.34702465
49prostate gland growth (GO:0060736)4.33648263
50aminoglycoside antibiotic metabolic process (GO:0030647)4.30890726
51branching involved in prostate gland morphogenesis (GO:0060442)4.30396897
52sympathetic nervous system development (GO:0048485)4.23192719
53glomerular basement membrane development (GO:0032836)4.15548118
54positive regulation of fatty acid beta-oxidation (GO:0032000)4.10247120
55bone remodeling (GO:0046849)4.09611005
56lateral sprouting from an epithelium (GO:0060601)4.03192234
57facial nerve structural organization (GO:0021612)4.00994709
58mammary gland epithelial cell proliferation (GO:0033598)4.00090090
59otic vesicle formation (GO:0030916)3.97348411
60extracellular regulation of signal transduction (GO:1900115)3.95304973
61extracellular negative regulation of signal transduction (GO:1900116)3.95304973
62regulation of histone phosphorylation (GO:0033127)3.94328167
63regulation of phospholipase A2 activity (GO:0032429)3.87910684
64gland morphogenesis (GO:0022612)3.86544596
65regulation of developmental pigmentation (GO:0048070)3.83126828
66CD4-positive or CD8-positive, alpha-beta T cell lineage commitment (GO:0043369)3.82429453
67inner cell mass cell proliferation (GO:0001833)3.80966810
68ubiquitin-dependent protein catabolic process via the multivesicular body sorting pathway (GO:0043163.79656334
69centriole replication (GO:0007099)3.76221145
70branch elongation of an epithelium (GO:0060602)3.75946838
71protein K48-linked deubiquitination (GO:0071108)3.74277864
72striated muscle atrophy (GO:0014891)3.72680591
73protein localization to Golgi apparatus (GO:0034067)3.72161844
74synaptic vesicle docking involved in exocytosis (GO:0016081)3.71204605
75lymphoid progenitor cell differentiation (GO:0002320)3.70931583
76negative regulation of bone mineralization (GO:0030502)3.70271602
77viral mRNA export from host cell nucleus (GO:0046784)3.67989241
78carnitine transmembrane transport (GO:1902603)3.67658185
79regulation of branching involved in prostate gland morphogenesis (GO:0060687)3.66429795
80negative regulation of activin receptor signaling pathway (GO:0032926)3.65009258
81desmosome organization (GO:0002934)3.64736392
82mesenchymal cell differentiation involved in renal system development (GO:2001012)3.63793459
83mesenchymal cell differentiation involved in kidney development (GO:0072161)3.63793459
84mesenchymal to epithelial transition (GO:0060231)3.58309287
85auditory receptor cell stereocilium organization (GO:0060088)3.58292701
86metanephros development (GO:0001656)3.57697497
87cellular response to interferon-alpha (GO:0035457)3.57454610
88mesenchymal cell proliferation (GO:0010463)3.53017343
89histone-serine phosphorylation (GO:0035404)3.52476523
90DNA demethylation (GO:0080111)3.51203797
91negative regulation of kidney development (GO:0090185)3.49734452
92skeletal muscle adaptation (GO:0043501)3.49017108
93maintenance of fidelity involved in DNA-dependent DNA replication (GO:0045005)3.47686305
94positive regulation of fatty acid oxidation (GO:0046321)3.44742079
95negative regulation of metanephros development (GO:0072217)3.44207675
96negative regulation of DNA-dependent DNA replication (GO:2000104)3.44014901
97regulation of mitochondrial depolarization (GO:0051900)3.41252699
98regulation of respiratory system process (GO:0044065)3.40944626
99mesenchymal cell development (GO:0014031)3.40769890
100carnitine transport (GO:0015879)3.40681330
101amino-acid betaine transport (GO:0015838)3.40681330
102* skeletal system morphogenesis (GO:0048705)3.39754363
103regulation of cellular senescence (GO:2000772)3.38633956
104keratinocyte proliferation (GO:0043616)3.38092999
105centrosome duplication (GO:0051298)3.35210306
106regulation of glomerulus development (GO:0090192)3.34317895
107cell proliferation involved in metanephros development (GO:0072203)3.34153087
108negative regulation of biomineral tissue development (GO:0070168)3.33424654
109outer ear morphogenesis (GO:0042473)3.32398700
110bone morphogenesis (GO:0060349)3.31479140
111hair follicle morphogenesis (GO:0031069)3.30674600
112protein K63-linked deubiquitination (GO:0070536)3.28638158
113negative regulation of fatty acid transport (GO:2000192)3.28097997
114mesenchymal cell differentiation (GO:0048762)3.28010771
115* anterior/posterior pattern specification (GO:0009952)3.27905036
116regulation of branching involved in salivary gland morphogenesis (GO:0060693)3.27599340
117regulation of centrosome duplication (GO:0010824)3.27498102
118cell proliferation involved in kidney development (GO:0072111)3.25452465
119positive regulation of bone remodeling (GO:0046852)3.25197524
120positive regulation of bone resorption (GO:0045780)3.25197524
121glomerular visceral epithelial cell development (GO:0072015)3.22926495
122toxin transport (GO:1901998)3.22356555
123regulation of cell proliferation involved in kidney development (GO:1901722)3.21066137
124negative regulation of leukocyte chemotaxis (GO:0002689)3.19821714
125muscle atrophy (GO:0014889)3.19575518
126cranial nerve structural organization (GO:0021604)3.14821769
127hemidesmosome assembly (GO:0031581)3.14740836
128regulation of RIG-I signaling pathway (GO:0039535)3.14307326
129proximal/distal pattern formation (GO:0009954)3.09251849
130energy homeostasis (GO:0097009)3.08051280
131replicative senescence (GO:0090399)3.06469120
132regulation of non-canonical Wnt signaling pathway (GO:2000050)3.05736763
133intracellular estrogen receptor signaling pathway (GO:0030520)3.05376321
134inner ear receptor stereocilium organization (GO:0060122)3.04461524
135melanin metabolic process (GO:0006582)3.04242903
136UDP-N-acetylglucosamine metabolic process (GO:0006047)3.03281646
137branching involved in mammary gland duct morphogenesis (GO:0060444)3.02494033
138lateral ventricle development (GO:0021670)3.01925507
139embryonic organ morphogenesis (GO:0048562)2.99806387
140negative regulation of reactive oxygen species metabolic process (GO:2000378)2.97842326
141viral genome replication (GO:0019079)2.97576469
142regulation of cell maturation (GO:1903429)2.96539989
143negative regulation of erythrocyte differentiation (GO:0045647)2.95879776
144oocyte development (GO:0048599)2.95781129
145regulation of chondrocyte differentiation (GO:0032330)2.95671996
146positive regulation of nitric-oxide synthase activity (GO:0051000)2.95521262
147response to pheromone (GO:0019236)2.95421185
148ventricular septum development (GO:0003281)2.94596275
149regulation of osteoblast proliferation (GO:0033688)2.93856483
150digestive tract morphogenesis (GO:0048546)2.93382085
151regulation of mammary gland epithelial cell proliferation (GO:0033599)2.93373801
152axis elongation (GO:0003401)2.93261800
153mammary gland alveolus development (GO:0060749)2.92040591
154pattern specification involved in kidney development (GO:0061004)2.91404836
155negative regulation of heart rate (GO:0010459)2.91247294
156regulation of centrosome cycle (GO:0046605)2.89975632
157organ growth (GO:0035265)2.89955201
158DNA dealkylation (GO:0035510)2.89510256
159trivalent inorganic anion homeostasis (GO:0072506)2.89272618
160phosphate ion homeostasis (GO:0055062)2.89272618
161embryonic camera-type eye development (GO:0031076)2.88568554
162cellular anion homeostasis (GO:0030002)2.88462492
163T cell lineage commitment (GO:0002360)2.88181284
164fat-soluble vitamin catabolic process (GO:0042363)2.87564273
165vitamin catabolic process (GO:0009111)2.87564273
166regulation of viral-induced cytoplasmic pattern recognition receptor signaling pathway (GO:0039531)2.85650938
167replication fork processing (GO:0031297)2.83497367
168histone H3-K9 methylation (GO:0051567)2.82364789
169mesenchymal to epithelial transition involved in metanephros morphogenesis (GO:0003337)2.81198519
170cranial nerve morphogenesis (GO:0021602)2.80428207
171enteric nervous system development (GO:0048484)2.80038989
172white fat cell differentiation (GO:0050872)2.78955249
173DNA topological change (GO:0006265)2.78350917
174cellular response to exogenous dsRNA (GO:0071360)2.77327447
175negative regulation of anoikis (GO:2000811)2.76934856
176adipose tissue development (GO:0060612)2.76417063
177metanephric mesenchyme development (GO:0072075)2.76009841
178regulation of sequestering of triglyceride (GO:0010889)2.75953894
179kidney mesenchyme development (GO:0072074)2.75356968
180positive regulation of protein import into nucleus, translocation (GO:0033160)2.75254864
181male meiosis I (GO:0007141)2.74587804
182mitotic sister chromatid cohesion (GO:0007064)2.74447500
183face development (GO:0060324)2.73541070
184embryonic skeletal joint morphogenesis (GO:0060272)2.72699462
185regulation of apoptotic process involved in morphogenesis (GO:1902337)2.72570923
186positive regulation of metanephros development (GO:0072216)2.72076051
187branching involved in ureteric bud morphogenesis (GO:0001658)2.71977867
188ureteric bud development (GO:0001657)2.71708426
189phenol-containing compound catabolic process (GO:0019336)2.71681498
190response to UV-C (GO:0010225)2.65659796
191regulation of nuclear cell cycle DNA replication (GO:0033262)2.63958564
192cellular response to estradiol stimulus (GO:0071392)2.63381938
193regulation of integrin-mediated signaling pathway (GO:2001044)2.61878960
194positive regulation of CREB transcription factor activity (GO:0032793)2.61537980
195negative regulation of systemic arterial blood pressure (GO:0003085)14.5033106

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1TP63_17297297_ChIP-ChIP_HaCaT_Human5.92896152
2SALL1_21062744_ChIP-ChIP_HESCs_Human4.14945129
3EZH2_22144423_ChIP-Seq_EOC_Human3.74577756
4FOXM1_23109430_ChIP-Seq_U2OS_Human3.29240595
5CIITA_18437201_ChIP-ChIP_Raji_B_and_iDC_Human3.11495569
6EED_16625203_ChIP-ChIP_MESCs_Mouse3.09264411
7* EZH2_18974828_ChIP-Seq_MESCs_Mouse3.05292942
8* RNF2_18974828_ChIP-Seq_MESCs_Mouse3.05292942
9* BMI1_23680149_ChIP-Seq_NPCS_Mouse2.96119646
10SUZ12_16625203_ChIP-ChIP_MESCs_Mouse2.81155653
11* PHC1_16625203_ChIP-ChIP_MESCs_Mouse2.80914565
12* JARID2_20075857_ChIP-Seq_MESCs_Mouse2.69626052
13* JARID2_20064375_ChIP-Seq_MESCs_Mouse2.69091872
14* EZH2_27304074_Chip-Seq_ESCs_Mouse2.68127915
15BP1_19119308_ChIP-ChIP_Hs578T_Human2.65112671
16* SUZ12_18692474_ChIP-Seq_MEFs_Mouse2.56572123
17* SUZ12_18692474_ChIP-Seq_MESCs_Mouse2.50055325
18* SUZ12_18974828_ChIP-Seq_MESCs_Mouse2.48792263
19GBX2_23144817_ChIP-Seq_PC3_Human2.47659195
20TP53_16413492_ChIP-PET_HCT116_Human2.47037428
21AR_21572438_ChIP-Seq_LNCaP_Human2.46334970
22* SUZ12_18555785_ChIP-Seq_MESCs_Mouse2.45979737
23ER_23166858_ChIP-Seq_MCF-7_Human2.40416550
24* TP53_20018659_ChIP-ChIP_R1E_Mouse2.33108452
25E2F7_22180533_ChIP-Seq_HELA_Human2.26248033
26* RNF2_16625203_ChIP-ChIP_MESCs_Mouse2.26035030
27ESR1_15608294_ChIP-ChIP_MCF-7_Human2.25213337
28TRIM28_21343339_ChIP-Seq_HEK293_Human2.09978377
29RNF2_27304074_Chip-Seq_ESCs_Mouse1.99776958
30* KDM5B_21448134_ChIP-Seq_MESCs_Mouse1.95309359
31CHD7_19251738_ChIP-ChIP_MESCs_Mouse1.94145981
32* CBX2_27304074_Chip-Seq_ESCs_Mouse1.90258234
33POU5F1_16153702_ChIP-ChIP_HESCs_Human1.87320965
34* SUZ12_27294783_Chip-Seq_ESCs_Mouse1.82627439
35* MTF2_20144788_ChIP-Seq_MESCs_Mouse1.82441565
36* EZH2_27294783_Chip-Seq_ESCs_Mouse1.82114928
37ESR1_21235772_ChIP-Seq_MCF-7_Human1.79951688
38VDR_23401126_ChIP-Seq_LCL-AND-THP1_Human1.79419449
39TDRD3_21172665_ChIP-Seq_MCF-7_Human1.70428153
40* SMAD3_18955504_ChIP-ChIP_HaCaT_Human1.64839745
41* SMAD2_18955504_ChIP-ChIP_HaCaT_Human1.64839745
42RXR_22108803_ChIP-Seq_LS180_Human1.62474432
43PADI4_21655091_ChIP-ChIP_MCF-7_Human1.60187526
44PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human1.57615624
45ZFP57_27257070_Chip-Seq_ESCs_Mouse1.55166782
46PKCTHETA_26484144_Chip-Seq_BREAST_Human1.53657678
47* SUZ12_20075857_ChIP-Seq_MESCs_Mouse1.52828575
48E2F1_21310950_ChIP-Seq_MCF-7_Human1.52734954
49PPARG_19300518_ChIP-PET_3T3-L1_Mouse1.52598916
50GLI1_17442700_ChIP-ChIP_MESCs_Mouse1.52129324
51SMAD_19615063_ChIP-ChIP_OVARY_Human1.51177751
52* RING1B_27294783_Chip-Seq_NPCs_Mouse1.49629853
53* RNF2_27304074_Chip-Seq_NSC_Mouse1.48889863
54PIAS1_25552417_ChIP-Seq_VCAP_Human1.47708623
55ERG_21242973_ChIP-ChIP_JURKAT_Human1.46133440
56HIF1A_21447827_ChIP-Seq_MCF-7_Human1.45752617
57* CDX2_20551321_ChIP-Seq_CACO-2_Human1.45020942
58ESR1_22446102_ChIP-Seq_UTERUS_Mouse1.44112517
59RUNX2_24764292_ChIP-Seq_MC3T3_Mouse1.44057856
60PPARD_23176727_ChIP-Seq_KERATINOCYTES_Mouse1.40088953
61CEBPD_23245923_ChIP-Seq_MEFs_Mouse1.38808776
62SOX9_24532713_ChIP-Seq_HFSC_Mouse1.38477712
63STAT5_23275557_ChIP-Seq_MAMMARY-EPITHELIUM_Mouse1.35992300
64* BRD4_25478319_ChIP-Seq_HGPS_Human1.35344158
65RUNX1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.34253097
66TRP63_18441228_ChIP-ChIP_KERATINOCYTES_Mouse1.30269088
67* KLF2_18264089_ChIP-ChIP_MESCs_Mouse1.29454581
68* KLF5_18264089_ChIP-ChIP_MESCs_Mouse1.29454581
69* KLF4_18264089_ChIP-ChIP_MESCs_Mouse1.29454581
70ZNF274_21170338_ChIP-Seq_K562_Hela1.29303482
71VDR_24787735_ChIP-Seq_THP-1_Human1.29215127
72* CDX2_19796622_ChIP-Seq_MESCs_Mouse1.27203796
73CHD1_26751641_Chip-Seq_LNCaP_Human1.26343879
74SMAD3_21741376_ChIP-Seq_EPCs_Human1.23754460
75ZFP281_18358816_ChIP-ChIP_MESCs_Mouse1.23474053
76ESR2_21235772_ChIP-Seq_MCF-7_Human1.20977604
77* RING1B_27294783_Chip-Seq_ESCs_Mouse1.19451410
78P300_19829295_ChIP-Seq_ESCs_Human1.16367847
79AHR_22903824_ChIP-Seq_MCF-7_Human1.15385480
80ARNT_22903824_ChIP-Seq_MCF-7_Human1.14664420
81CTNNB1_24651522_ChIP-Seq_LGR5+_INTESTINAL_STEM_Human1.14509709
82UBF1/2_26484160_Chip-Seq_HMECs_Human1.13136711
83NR1I2_20693526_ChIP-Seq_LIVER_Mouse1.12455862
84MEF2A_21415370_ChIP-Seq_HL-1_Mouse1.12418770
85TFAP2C_20629094_ChIP-Seq_MCF-7_Human1.10327033
86* E2F4_21247883_ChIP-Seq_LYMPHOBLASTOID_Human1.10216309
87* PPARG_20176806_ChIP-Seq_3T3-L1_Mouse1.09380650
88SMAD3_22036565_ChIP-Seq_ESCs_Mouse1.08897676
89IGF1R_20145208_ChIP-Seq_DFB_Human1.08255435
90NOTCH1_21737748_ChIP-Seq_TLL_Human1.07108897
91EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human1.07068306
92E2F4_17652178_ChIP-ChIP_JURKAT_Human1.06338301
93BCAT_22108803_ChIP-Seq_LS180_Human1.06216926
94WT1_20215353_ChIP-ChIP_NEPHRON_PROGENITOR_Mouse1.05962290
95KDM5A_27292631_Chip-Seq_BREAST_Human1.05409357
96PCGF2_27294783_Chip-Seq_ESCs_Mouse1.05287472
97ZFP281_27345836_Chip-Seq_ESCs_Mouse1.04977913
98TP63_19390658_ChIP-ChIP_HaCaT_Human1.03888110
99ERA_27197147_Chip-Seq_ENDOMETRIOID-ADENOCARCINOMA_Human1.03306242
100ERA_21632823_ChIP-Seq_H3396_Human1.00900844
101* WT1_25993318_ChIP-Seq_PODOCYTE_Human0.99141250
102* BACH1_22875853_ChIP-PCR_HELA_AND_SCP4_Human0.98999507
103SREBP1_19666523_ChIP-Seq_LIVER_Mouse0.98378427
104SUZ12_27294783_Chip-Seq_NPCs_Mouse0.97969864
105* TFAP2A_17053090_ChIP-ChIP_MCF-7_Human0.97844855
106RUNX1_27514584_Chip-Seq_MCF-7_Human0.97821286
107GATA2_21186366_ChIP-Seq_BM-HSCs_Mouse0.97805184
108ZNF217_24962896_ChIP-Seq_MCF-7_Human0.95658582
109CJUN_26792858_Chip-Seq_BT549_Human0.94623488
110CDKN2AIP_20523734_ChIP-Seq_CORTICAL_Neurons0.94572962
111GATA3_24758297_ChIP-Seq_MCF-7_Human0.94034910
112TP53_23651856_ChIP-Seq_MEFs_Mouse0.93699144
113TBX5_21415370_ChIP-Seq_HL-1_Mouse0.93338642
114TP53_22127205_ChIP-Seq_IMR90_Human0.92684742
115JUN_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human0.92220938
116TP53_18474530_ChIP-ChIP_U2OS_Human0.91760140
117SOX2_20726797_ChIP-Seq_SW620_Human0.91591659
118RACK7_27058665_Chip-Seq_MCF-7_Human0.91006124
119FOXM1_26456572_ChIP-Seq_MCF-7_Human0.90303115
120SMAD4_21799915_ChIP-Seq_A2780_Human0.89225941
121SMAD2/3_21741376_ChIP-Seq_EPCs_Human0.89122144
122TRIM28_17542650_ChIP-ChIP_NTERA2_Human0.89067248
123GATA6_25053715_ChIP-Seq_YYC3_Human0.88847363
124RCOR2_21632747_ChIP-Seq_MESCs_Mouse0.88843920
125* SA1_22415368_ChIP-Seq_MEFs_Mouse0.88753764
126RARG_19884340_ChIP-ChIP_MEFs_Mouse0.88724260
127AR_25329375_ChIP-Seq_VCAP_Human0.87761652
128SMAD3_21741376_ChIP-Seq_HESCs_Human0.87308786
129ESR1_20079471_ChIP-ChIP_T-47D_Human0.87279004
130IKZF1_21737484_ChIP-ChIP_HCT116_Human0.86981085
131CTBP1_25329375_ChIP-Seq_LNCAP_Human0.85884231
132CEBPB_26923725_Chip-Seq_MESODERM_Mouse0.85070104
133EP300_20729851_ChIP-Seq_FORBRAIN_MIDBRAIN_LIMB_HEART_Mouse0.82376808
134RUNX2_22187159_ChIP-Seq_PCA_Human0.82298967
135CEBPD_21427703_ChIP-Seq_3T3-L1_Mouse0.82238735
136* FOXA1_26743006_Chip-Seq_LNCaP-abl_Human0.81228643
137E2F1_17053090_ChIP-ChIP_MCF-7_Human0.81078452
138HOXB7_26014856_ChIP-Seq_BT474_Human0.80834631
139WT1_19549856_ChIP-ChIP_CCG9911_Human0.80508193
140NANOG_18555785_Chip-Seq_ESCs_Mouse0.80358128
141NFE2_27457419_Chip-Seq_LIVER_Mouse0.80111208
142PCGF2_27294783_Chip-Seq_NPCs_Mouse0.79457584
143* YY1_22570637_ChIP-Seq_MALME-3M_Human0.79431886
144DACH1_20351289_ChIP-Seq_MDA-MB-231_Human0.79318674
145FOXM1_25889361_ChIP-Seq_OE33_AND_U2OS_Human0.79040179
146CEBPB_26923725_Chip-Seq_HEMANGIOBLAST_Mouse0.78888697
147BCL3_23251550_ChIP-Seq_MUSCLE_Mouse0.78696302
148SMAD4_19686287_ChIP-ChIP_HaCaT_Human0.78267543
149* PBX_27287812_Chip-Seq_EMBYONIC-LIMB_Mouse0.77990287
150EBF1_22473956_ChIP-Seq_BONE_MARROW_Mouse0.77568233
151ISL1_27105846_Chip-Seq_CPCs_Mouse0.77309273
152EWS-FLI1_20517297_ChIP-Seq_SK-N-MC_Human0.77034782
153* STAT3_19079543_ChIP-ChIP_MESCs_Mouse0.76965578
154KLF6_26769127_Chip-Seq_PDAC-Cell_line_Human0.76924384
155TEAD4_22529382_ChIP-Seq_TROPHECTODERM_Mouse0.76348274
156TCFCP2L1_18555785_Chip-Seq_ESCs_Mouse0.76310468
157SMAD4_21741376_ChIP-Seq_HESCs_Human0.76142556
158TCF21_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human0.75640114
159TBL1_22424771_ChIP-Seq_293T_Human0.75636763
160TET1_21451524_ChIP-Seq_MESCs_Mouse0.73726658
161E2F1_20622854_ChIP-Seq_HELA_Human0.73575938
162EWS_26573619_Chip-Seq_HEK293_Human0.73450875
163DMRT1_23473982_ChIP-Seq_TESTES_Mouse0.73179136
164NKX2-5_21415370_ChIP-Seq_HL-1_Mouse0.70506349

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0009780_abnormal_chondrocyte_physiolo9.85901621
2MP0004381_abnormal_hair_follicle4.74322820
3MP0000372_irregular_coat_pigmentation4.31875454
4MP0001348_abnormal_lacrimal_gland4.00516514
5MP0008057_abnormal_DNA_replication3.92301356
6MP0008961_abnormal_basal_metabolism3.20841873
7MP0010307_abnormal_tumor_latency3.17164006
8MP0002009_preneoplasia3.12023171
9MP0001881_abnormal_mammary_gland3.11763215
10MP0005075_abnormal_melanosome_morpholog2.95940560
11MP0003136_yellow_coat_color2.95163372
12MP0000569_abnormal_digit_pigmentation2.90163196
13MP0003950_abnormal_plasma_membrane2.81277476
14MP0000566_synostosis2.62517289
15MP0003942_abnormal_urinary_system2.61871189
16MP0003183_abnormal_peptide_metabolism2.56671232
17MP0001542_abnormal_bone_strength2.47789707
18MP0002249_abnormal_larynx_morphology2.47441725
19MP0003890_abnormal_embryonic-extraembry2.42811176
20MP0005503_abnormal_tendon_morphology2.36712595
21MP0005171_absent_coat_pigmentation2.33855462
22MP0002396_abnormal_hematopoietic_system2.32774454
23MP0008995_early_reproductive_senescence2.31639998
24MP0003705_abnormal_hypodermis_morpholog2.26589647
25MP0005646_abnormal_pituitary_gland2.22165344
26MP0000627_abnormal_mammary_gland2.18438563
27MP0003941_abnormal_skin_development2.16089828
28MP0009250_abnormal_appendicular_skeleto2.08294515
29MP0003787_abnormal_imprinting2.04891095
30MP0003385_abnormal_body_wall2.00670647
31MP0009697_abnormal_copulation1.90523645
32MP0010030_abnormal_orbit_morphology1.90019557
33MP0005670_abnormal_white_adipose1.89979220
34MP0002177_abnormal_outer_ear1.87425880
35MP0005275_abnormal_skin_tensile1.86870066
36MP0003646_muscle_fatigue1.82749495
37MP0000678_abnormal_parathyroid_gland1.82335672
38MP0004233_abnormal_muscle_weight1.80901496
39MP0000049_abnormal_middle_ear1.79161179
40MP0002736_abnormal_nociception_after1.78912212
41MP0003879_abnormal_hair_cell1.75620276
42MP0005647_abnormal_sex_gland1.74820019
43MP0010386_abnormal_urinary_bladder1.66197078
44MP0008007_abnormal_cellular_replicative1.65558395
45MP0002751_abnormal_autonomic_nervous1.64329953
46MP0008438_abnormal_cutaneous_collagen1.61598632
47MP0002938_white_spotting1.60826783
48MP0002796_impaired_skin_barrier1.59850107
49MP0004272_abnormal_basement_membrane1.58662316
50MP0002132_abnormal_respiratory_system1.56535455
51MP0002282_abnormal_trachea_morphology1.56442277
52MP0005377_hearing/vestibular/ear_phenot1.54874696
53MP0003878_abnormal_ear_physiology1.54874696
54MP0008004_abnormal_stomach_pH1.49441960
55MP0005409_darkened_coat_color1.49128264
56MP0005408_hypopigmentation1.48775263
57MP0004043_abnormal_pH_regulation1.48215570
58MP0005266_abnormal_metabolism1.47542429
59MP0006276_abnormal_autonomic_nervous1.46994302
60MP0008877_abnormal_DNA_methylation1.46702482
61MP0002163_abnormal_gland_morphology1.43845993
62MP0002932_abnormal_joint_morphology1.43397717
63MP0009384_cardiac_valve_regurgitation1.42038430
64MP0000516_abnormal_urinary_system1.40389756
65MP0005367_renal/urinary_system_phenotyp1.40389756
66MP0000579_abnormal_nail_morphology1.40319147
67MP0002168_other_aberrant_phenotype1.38941316
68MP0000534_abnormal_ureter_morphology1.37104945
69MP0000681_abnormal_thyroid_gland1.36972624
70MP0001727_abnormal_embryo_implantation1.33939690
71MP0003279_aneurysm1.33625717
72MP0003195_calcinosis1.31142080
73MP0005508_abnormal_skeleton_morphology1.28909320
74MP0005379_endocrine/exocrine_gland_phen1.25963859
75MP0001188_hyperpigmentation1.25604372
76MP0002060_abnormal_skin_morphology1.25404340
77MP0010094_abnormal_chromosome_stability1.25263844
78MP0001346_abnormal_lacrimal_gland1.24934616
79MP0003786_premature_aging1.23606550
80MP0001243_abnormal_dermal_layer1.22905559
81MP0001919_abnormal_reproductive_system1.22608022
82MP0000015_abnormal_ear_pigmentation1.20889053
83MP0005623_abnormal_meninges_morphology1.20875177
84MP0002098_abnormal_vibrissa_morphology1.19602665
85MP0002876_abnormal_thyroid_physiology1.19395579
86MP0001340_abnormal_eyelid_morphology1.19067267
87MP0005645_abnormal_hypothalamus_physiol1.19026272
88MP0000762_abnormal_tongue_morphology1.18142327
89MP0000427_abnormal_hair_cycle1.13662200
90MP0000163_abnormal_cartilage_morphology1.13549056
91MP0000767_abnormal_smooth_muscle1.12800835
92MP0004883_abnormal_blood_vessel1.12745387
93MP0002233_abnormal_nose_morphology1.11873918
94MP0002877_abnormal_melanocyte_morpholog1.10957360
95MP0000383_abnormal_hair_follicle1.10842795
96MP0002184_abnormal_innervation1.08962229
97MP0005174_abnormal_tail_pigmentation1.08837821
98MP0005257_abnormal_intraocular_pressure1.08794858
99MP0003453_abnormal_keratinocyte_physiol1.06553568
100MP0001486_abnormal_startle_reflex1.06271639
101MP0009379_abnormal_foot_pigmentation1.04183559
102MP0001879_abnormal_lymphatic_vessel1.03744604
103MP0002116_abnormal_craniofacial_bone1.01620813
104MP0009672_abnormal_birth_weight1.00730514
105MP0010329_abnormal_lipoprotein_level0.99748968
106MP0000470_abnormal_stomach_morphology0.99617399
107MP0002075_abnormal_coat/hair_pigmentati0.99546000
108MP0001958_emphysema0.99296549
109MP0003755_abnormal_palate_morphology0.99175235
110MP0000538_abnormal_urinary_bladder0.99084493
111MP0000428_abnormal_craniofacial_morphol0.98249367
112MP0002896_abnormal_bone_mineralization0.97254252
113MP0002108_abnormal_muscle_morphology0.96982759
114MP0000750_abnormal_muscle_regeneration0.96134996
115MP0004885_abnormal_endolymph0.94718842
116MP0002332_abnormal_exercise_endurance0.92752809
117MP0001186_pigmentation_phenotype0.92426454
118MP0005389_reproductive_system_phenotype0.92379843
119MP0000432_abnormal_head_morphology0.92074566
120MP0002998_abnormal_bone_remodeling0.89648776
121MP0003938_abnormal_ear_development0.89353072
122MP0002277_abnormal_respiratory_mucosa0.87827928
123MP0001299_abnormal_eye_distance/0.87269567
124MP0004197_abnormal_fetal_growth/weight/0.86485203
125MP0003693_abnormal_embryo_hatching0.86332838
126* MP0002115_abnormal_skeleton_extremities0.86331235
127MP0006292_abnormal_olfactory_placode0.85975004
128MP0000647_abnormal_sebaceous_gland0.85712774
129* MP0002114_abnormal_axial_skeleton0.84675085
130MP0005501_abnormal_skin_physiology0.84041290
131MP0002638_abnormal_pupillary_reflex0.83481470
132MP0002970_abnormal_white_adipose0.83473628
133MP0000371_diluted_coat_color0.82967984
134* MP0002109_abnormal_limb_morphology0.82867525
135MP0001968_abnormal_touch/_nociception0.82243392
136MP0003936_abnormal_reproductive_system0.81153897
137MP0008058_abnormal_DNA_repair0.81117410
138MP0000759_abnormal_skeletal_muscle0.81072623
139MP0004142_abnormal_muscle_tone0.80308972
140MP0004130_abnormal_muscle_cell0.79078682
141MP0004145_abnormal_muscle_electrophysio0.77565752
142MP0000467_abnormal_esophagus_morphology0.77389229
143MP0009115_abnormal_fat_cell0.76713238
144MP0002933_joint_inflammation0.76651367
145MP0002971_abnormal_brown_adipose0.75490620
146MP0003566_abnormal_cell_adhesion0.75286177
147MP0000955_abnormal_spinal_cord0.73829838
148MP0005395_other_phenotype0.73644749
149MP0008872_abnormal_physiological_respon0.73525922
150MP0003959_abnormal_lean_body0.70635281
151MP0001873_stomach_inflammation0.70496781
152MP0005448_abnormal_energy_balance0.70062061
153MP0002095_abnormal_skin_pigmentation0.69424011
154MP0005334_abnormal_fat_pad0.69404905
155MP0002160_abnormal_reproductive_system0.69154789
156MP0005076_abnormal_cell_differentiation0.66399329
157MP0003111_abnormal_nucleus_morphology0.64742686
158MP0005369_muscle_phenotype0.64231530
159MP0002084_abnormal_developmental_patter0.64214400
160MP0002088_abnormal_embryonic_growth/wei0.63408867
161MP0005410_abnormal_fertilization0.62075000
162MP0009703_decreased_birth_body0.61594945
163MP0003984_embryonic_growth_retardation0.61560712
164MP0005376_homeostasis/metabolism_phenot0.59054566
165MP0000013_abnormal_adipose_tissue0.57753814
166MP0003077_abnormal_cell_cycle0.54160830
167MP0000733_abnormal_muscle_development0.54144718
168MP0002269_muscular_atrophy0.53833823
169MP0000749_muscle_degeneration0.53123499
170MP0010368_abnormal_lymphatic_system0.51503279
171MP0001672_abnormal_embryogenesis/_devel0.48746912
172MP0005380_embryogenesis_phenotype0.48746912
173MP0005164_abnormal_response_to0.47870352

Predicted human phenotypes

RankGene SetZ-score
1Chromsome breakage (HP:0040012)8.96729849
2Chromosomal breakage induced by crosslinking agents (HP:0003221)8.04612325
3Protruding tongue (HP:0010808)6.49407230
4Selective tooth agenesis (HP:0001592)5.88879308
5Concave nail (HP:0001598)5.22242902
6Parakeratosis (HP:0001036)4.96712542
7Acute lymphatic leukemia (HP:0006721)4.82815893
8Alopecia of scalp (HP:0002293)4.62895846
9Oligodontia (HP:0000677)4.29371403
10Aplasia/Hypoplasia of the tibia (HP:0005772)4.18821270
11Pancreatic cysts (HP:0001737)3.89465108
12Aplasia/Hypoplasia of the uvula (HP:0010293)3.89129656
13Hypothermia (HP:0002045)3.86345071
14Abnormality of chromosome stability (HP:0003220)3.86033410
15Pancreatic fibrosis (HP:0100732)3.80551382
16Unilateral renal agenesis (HP:0000122)3.77578037
17Genetic anticipation (HP:0003743)3.77547687
18Recurrent corneal erosions (HP:0000495)3.75232615
19Hypotrichosis (HP:0001006)3.66545822
20Coronal craniosynostosis (HP:0004440)3.63208912
21Midline defect of the nose (HP:0004122)3.62304303
22Meckel diverticulum (HP:0002245)3.60894788
23Abnormality of the carotid arteries (HP:0005344)3.58880820
24Patellar aplasia (HP:0006443)3.52940785
25Papillary thyroid carcinoma (HP:0002895)3.51807127
26Abnormality of the ileum (HP:0001549)3.50446419
27Alacrima (HP:0000522)3.47307834
28Abnormality of the preputium (HP:0100587)3.39268935
29Follicular hyperkeratosis (HP:0007502)3.38211030
30Aplasia/Hypoplasia of the patella (HP:0006498)3.35194207
31Nasolacrimal duct obstruction (HP:0000579)3.30840611
32Hypoplastic ischia (HP:0003175)3.29490290
33Absent eyebrow (HP:0002223)3.28070699
34Cystic liver disease (HP:0006706)3.27467566
35Abnormality of the parietal bone (HP:0002696)3.19513699
36Conical tooth (HP:0000698)3.04586014
37Aplasia/Hypoplasia of the tongue (HP:0010295)3.02583816
38Mesangial abnormality (HP:0001966)3.00634299
39Dysmetric saccades (HP:0000641)2.97861576
40Long toe (HP:0010511)2.91144231
41Abnormality of the ischium (HP:0003174)2.89461887
42True hermaphroditism (HP:0010459)2.81742922
43Abnormality of the peritoneum (HP:0002585)2.78568528
44Clubbing of toes (HP:0100760)2.76656121
45Type 1 muscle fiber predominance (HP:0003803)2.76361136
46White forelock (HP:0002211)2.71730858
47Decreased lacrimation (HP:0000633)2.70989370
48Abnormality of the lacrimal duct (HP:0011481)2.70396614
49Growth hormone excess (HP:0000845)2.69213285
50Bladder diverticulum (HP:0000015)2.68505779
51Infantile muscular hypotonia (HP:0008947)2.68117235
52Bilateral sensorineural hearing impairment (HP:0008619)2.63397149
53Absent frontal sinuses (HP:0002688)2.63067796
54Abnormality of midbrain morphology (HP:0002418)2.61576423
55Molar tooth sign on MRI (HP:0002419)2.61576423
56Cheilitis (HP:0100825)2.60085432
57High pitched voice (HP:0001620)2.59672744
58Abnormality of molar morphology (HP:0011070)2.53904687
59Abnormality of molar (HP:0011077)2.53904687
60Agitation (HP:0000713)2.53748004
61Macroglossia (HP:0000158)2.53336728
62Patchy hypopigmentation of hair (HP:0011365)2.52701732
63Abnormality of the nasolacrimal system (HP:0000614)2.48817301
64Renovascular hypertension (HP:0100817)2.47578444
65Chronic otitis media (HP:0000389)2.43849406
66Premature rupture of membranes (HP:0001788)2.43086671
67Turricephaly (HP:0000262)2.41790098
68Triphalangeal thumb (HP:0001199)2.39732554
69Short thumb (HP:0009778)2.38720082
70Osteomalacia (HP:0002749)2.38118303
71Microretrognathia (HP:0000308)2.37548780
72Hyperphosphatemia (HP:0002905)2.37524280
73Broad metatarsal (HP:0001783)2.37131594
74Flat cornea (HP:0007720)2.35916516
75Vertebral compression fractures (HP:0002953)2.35793444
76Fair hair (HP:0002286)2.35244119
77Hyperacusis (HP:0010780)2.34349180
78Renal cortical cysts (HP:0000803)2.34227058
79Small intestinal stenosis (HP:0012848)2.32364068
80Duodenal stenosis (HP:0100867)2.32364068
81Abnormality of permanent molar morphology (HP:0011071)2.31742030
82Abnormality of the dental root (HP:0006486)2.31742030
83Taurodontia (HP:0000679)2.31742030
84Aplasia cutis congenita (HP:0001057)2.30356267
85Down-sloping shoulders (HP:0200021)2.28305076
86Volvulus (HP:0002580)2.26367104
87Premature skin wrinkling (HP:0100678)2.26098050
88Microdontia (HP:0000691)2.23559822
89Elfin facies (HP:0004428)2.23151971
90Acanthosis nigricans (HP:0000956)2.23090494
91Fragile skin (HP:0001030)2.21514934
92Absent eyelashes (HP:0000561)2.21315860
93Abnormality of dental color (HP:0011073)2.19221781
94Tarsal synostosis (HP:0008368)2.16597271
95Atrophic scars (HP:0001075)2.16381948
96Generalized hypopigmentation of hair (HP:0011358)2.15253391
97Astigmatism (HP:0000483)2.14935434
98Abnormality of the renal cortex (HP:0011035)2.14321289
99Confusion (HP:0001289)2.14283264
100Abnormality of incisor morphology (HP:0011063)2.13080333
101Renal dysplasia (HP:0000110)2.13011897
102Corneal erosion (HP:0200020)2.12969435
103Abnormal hemoglobin (HP:0011902)2.10683977
104Protrusio acetabuli (HP:0003179)2.09898424
105Absent/shortened dynein arms (HP:0200106)2.09632971
106Dynein arm defect of respiratory motile cilia (HP:0012255)2.09632971
107Abnormality of the nasal septum (HP:0000419)2.08591310
108Spinal cord lesions (HP:0100561)2.07255305
109Syringomyelia (HP:0003396)2.07255305
110Tapered finger (HP:0001182)2.05638377
111Absent hair (HP:0002298)2.05503910
112Poor coordination (HP:0002370)2.05420939
113Absent radius (HP:0003974)2.03601335
114Abnormality of the dental pulp (HP:0006479)2.02964475
115Shallow orbits (HP:0000586)2.02445195
116Underdeveloped nasal alae (HP:0000430)2.02423863
117Sloping forehead (HP:0000340)2.02156965
118Ulnar claw (HP:0001178)2.00631768
119Mediastinal lymphadenopathy (HP:0100721)1.99328329
120Preaxial hand polydactyly (HP:0001177)1.97508076
121Abnormality of alanine metabolism (HP:0010916)1.97501640
122Hyperalaninemia (HP:0003348)1.97501640
123Abnormality of pyruvate family amino acid metabolism (HP:0010915)1.97501640
124Arteriovenous malformation (HP:0100026)1.97060014
125Intracellular accumulation of autofluorescent lipopigment storage material (HP:0003204)1.96235034
126Renal duplication (HP:0000075)1.95241279
127Synostosis involving bones of the lower limbs (HP:0009138)1.95185976
128Synostosis involving bones of the feet (HP:0009140)1.95185976
129Accelerated skeletal maturation (HP:0005616)1.95027828
130Renal agenesis (HP:0000104)1.94637206
131Bradycardia (HP:0001662)1.92987224
132Overriding aorta (HP:0002623)1.92460619
133Hyperventilation (HP:0002883)1.92079140
134Oligohydramnios (HP:0001562)1.91863749
135Rectovaginal fistula (HP:0000143)1.90746432
136Rectal fistula (HP:0100590)1.90746432
137Congenital primary aphakia (HP:0007707)1.90391352
138Septo-optic dysplasia (HP:0100842)1.90142898
139Aplasia/Hypoplasia of the frontal sinuses (HP:0009119)1.89504280
140Oligomenorrhea (HP:0000876)1.89177192
141Lip pit (HP:0100267)1.89123257
142Partial duplication of the phalanx of hand (HP:0009999)1.88902521
143Sparse lateral eyebrow (HP:0005338)1.88236330
144Shawl scrotum (HP:0000049)1.88146049
145Gait imbalance (HP:0002141)1.87089607
146Absent forearm bone (HP:0003953)1.86622022
147Aplasia involving forearm bones (HP:0009822)1.86622022
148Embryonal renal neoplasm (HP:0011794)1.86167358
149Nephroblastoma (Wilms tumor) (HP:0002667)1.85382961
150Lissencephaly (HP:0001339)1.84793491
151Ankle contracture (HP:0006466)1.83939148
152Narrow nasal bridge (HP:0000446)1.83899152
153Nemaline bodies (HP:0003798)1.83686845
154Nephronophthisis (HP:0000090)1.82426795
155Hypercortisolism (HP:0001578)1.82408869
156Thyroid carcinoma (HP:0002890)1.81510675
157Limited hip movement (HP:0008800)1.81371061
158Cardiovascular calcification (HP:0011915)1.80997992
159Prostate neoplasm (HP:0100787)1.80643101
160Abnormality of the diencephalon (HP:0010662)1.79531479
161Dandy-Walker malformation (HP:0001305)1.79407475
162Neonatal hypoglycemia (HP:0001998)1.78821569
163Decreased subcutaneous fat (HP:0001002)1.78719535
164Preaxial foot polydactyly (HP:0001841)1.78397404
165Febrile seizures (HP:0002373)1.78349816
166Muscle fiber inclusion bodies (HP:0100299)1.77927295
167Partial duplication of thumb phalanx (HP:0009944)1.77047341
168Abnormality of calcium-phosphate metabolism (HP:0100530)1.76938201
169Mitral stenosis (HP:0001718)1.76545941
170Redundant skin (HP:0001582)1.76533872
171Aplasia involving bones of the extremities (HP:0009825)1.76227237
172Aplasia involving bones of the upper limbs (HP:0009823)1.76227237
173Aplasia of the phalanges of the hand (HP:0009802)1.76227237
174Intestinal fistula (HP:0100819)1.75914768
175Muscle fiber cytoplasmatic inclusion bodies (HP:0100303)1.75866908
176Intestinal atresia (HP:0011100)1.75587535
177Abnormality of the duodenum (HP:0002246)1.75513778
178Humeroradial synostosis (HP:0003041)1.74987167
179Synostosis involving the elbow (HP:0003938)1.74987167
180Anophthalmia (HP:0000528)1.74485513
181J-shaped sella turcica (HP:0002680)1.73617640
182Vascular calcification (HP:0004934)1.73362069
183Prominent supraorbital ridges (HP:0000336)1.72546657
184Broad toe (HP:0001837)1.71964270
185Anhidrosis (HP:0000970)1.71464611
186Cutaneous finger syndactyly (HP:0010554)1.70933498
187Breech presentation (HP:0001623)1.69624824
188Furrowed tongue (HP:0000221)1.68881690
189Inability to walk (HP:0002540)1.68798414
190Progressive cerebellar ataxia (HP:0002073)1.68316604
191Nail dystrophy (HP:0008404)1.68293374
192Bowel diverticulosis (HP:0005222)1.68278825
193Plantar hyperkeratosis (HP:0007556)1.68230372
194Increased neuronal autofluorescent lipopigment (HP:0002074)1.68228174

Predicted kinase interactions (KEA)

RankGene SetZ-score
1FRK5.19068325
2SIK34.24767031
3EPHB23.64313292
4PIK3CA3.56990115
5YES13.41337498
6CASK3.23452081
7SIK13.12894236
8IKBKE2.92751211
9DDR22.81847255
10EEF2K2.77532888
11MAPK152.73229107
12CHUK2.70829880
13TRIB32.57749282
14MUSK2.45254051
15UHMK12.36931167
16TNK22.33579273
17CDK192.26939280
18TLK12.25137646
19ACVR1B2.07515814
20SIK22.04728361
21PINK12.04020520
22PNCK2.01312742
23RPS6KA22.00313922
24TNIK1.90088805
25LATS21.84863589
26BUB11.82121338
27INSRR1.81804102
28WNK41.74404708
29PLK41.71390055
30DMPK1.69556721
31MATK1.67165233
32TRPM71.65827510
33DYRK1B1.65113871
34BMX1.62916421
35ERBB31.57072849
36MAP3K61.53787906
37MAP2K71.51616787
38NEK91.49510346
39AKT21.48311143
40CDC71.47126130
41PRKD21.46008671
42ICK1.43244678
43CDK81.39765545
44PRPF4B1.37336364
45SRPK11.36960588
46LIMK11.36862494
47LATS11.31819535
48MST1R1.31693348
49PDGFRB1.29896434
50AKT31.28177300
51PDGFRA1.28030867
52GRK11.24821616
53FER1.21578704
54CHEK21.13905437
55CDC42BPA1.13757041
56OXSR11.12987573
57CDK61.12437123
58MAP3K111.12100053
59STK381.10303320
60PHKG11.08565454
61PHKG21.08565454
62PAK31.07459194
63MAPKAPK31.05594925
64MAPK41.05421897
65CDK71.04826906
66HIPK21.04585268
67OBSCN1.03556929
68GRK71.00978180
69NLK1.00122185
70CDK120.99607927
71CAMK10.97869475
72MTOR0.96691385
73MAPK110.96618242
74CDK40.94809078
75MARK20.94732461
76CHEK10.93909678
77AURKA0.93447615
78PIM20.93351949
79NUAK10.91844667
80NTRK10.91346412
81NEK20.88935959
82TGFBR10.87898491
83TAOK30.87707032
84DYRK20.85582128
85TTK0.84843792
86MAPK130.84602285
87MAP3K120.84027593
88RPS6KL10.83425128
89RPS6KC10.83425128
90CAMK1D0.82305038
91PLK10.82255310
92TAOK20.82028155
93ADRBK20.79485198
94ATR0.79226927
95EPHA30.77015302
96PAK20.76251381
97CDK11A0.75184961
98TTN0.74454588
99EIF2AK20.73415063
100ADRBK10.69627443
101PRKG20.68504775
102RPS6KA60.68119233
103PDPK10.67864407
104PAK10.67654521
105MAP3K20.67558015
106TYRO30.67099673
107CSNK1G10.66079226
108PRKCI0.65879925
109CDK150.63124323
110MAPKAPK20.62630628
111PTK20.61227859
112LMTK20.61103667
113MET0.60639832
114CDK180.59906403
115PRKAA20.59420891
116CSK0.58814054
117IRAK10.58663233
118MAPK100.58481198
119FGR0.58471614
120MYLK0.57544023
121MELK0.57051963
122PRKAA10.57049857
123CAMK1G0.56753081
124NEK60.56173478
125CSNK1E0.55930815
126PRKCE0.53897247
127TEC0.53713434
128BMPR1B0.53560638
129STK38L0.53541506
130ATM0.53486187
131MAPKAPK50.52932785
132RPS6KA30.52659352
133FGFR20.52176425
134MAPK140.52115979
135CDK10.51929470
136WNK10.51586595
137CAMKK20.51505991
138GSK3A0.50778979
139ILK0.50461585
140RPS6KB20.49271452
141TXK0.48884156
142MAPK30.47764545
143IRAK30.47607678
144HCK0.47558315
145AKT10.46096281
146PTK60.45838484
147PIM10.45570174
148BMPR20.44803744
149NME20.44743931
150ZAK0.44017169
151GSK3B0.43577357
152DAPK10.42345932
153ABL10.42123237
154ERN10.42036756
155MKNK20.41102433
156CDK20.39216724
157IRAK20.37287781
158MAP2K10.36024360
159TGFBR20.34983832
160CAMK40.34459350
161MAPK80.33054202
162MKNK10.32048929
163FGFR10.31916601
164PKN10.31634541
165MARK30.31261429
166SRC0.31224207
167CAMK2A0.30248838
168RPS6KB10.28774405

Predicted pathways (KEGG)

RankGene SetZ-score
1Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005336.13670364
2Homologous recombination_Homo sapiens_hsa034404.49878489
3Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006034.48275563
4Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006043.29503797
5Nitrogen metabolism_Homo sapiens_hsa009102.99620314
6Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005122.88879353
7Lysine degradation_Homo sapiens_hsa003102.87597390
8Fatty acid biosynthesis_Homo sapiens_hsa000612.66659457
9Sulfur relay system_Homo sapiens_hsa041222.65836329
10Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001302.62344239
11Taurine and hypotaurine metabolism_Homo sapiens_hsa004302.59053981
12Selenocompound metabolism_Homo sapiens_hsa004502.37267190
13Basal cell carcinoma_Homo sapiens_hsa052172.30195548
14Hedgehog signaling pathway_Homo sapiens_hsa043402.23333610
15Fatty acid elongation_Homo sapiens_hsa000622.05283922
16Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa049612.03813470
17Regulation of lipolysis in adipocytes_Homo sapiens_hsa049231.99956640
18One carbon pool by folate_Homo sapiens_hsa006701.94097314
19mRNA surveillance pathway_Homo sapiens_hsa030151.84603879
20Non-homologous end-joining_Homo sapiens_hsa034501.83599116
21Ovarian steroidogenesis_Homo sapiens_hsa049131.83288167
22Choline metabolism in cancer_Homo sapiens_hsa052311.82369754
23Wnt signaling pathway_Homo sapiens_hsa043101.63667879
24RNA transport_Homo sapiens_hsa030131.62574297
25Nicotine addiction_Homo sapiens_hsa050331.56708589
26Notch signaling pathway_Homo sapiens_hsa043301.56261565
27Arachidonic acid metabolism_Homo sapiens_hsa005901.39842337
28Neuroactive ligand-receptor interaction_Homo sapiens_hsa040801.36709107
29Basal transcription factors_Homo sapiens_hsa030221.36394309
30Melanoma_Homo sapiens_hsa052181.35164717
31ECM-receptor interaction_Homo sapiens_hsa045121.31148251
32Axon guidance_Homo sapiens_hsa043601.30369494
33Pancreatic cancer_Homo sapiens_hsa052121.21919210
34Hippo signaling pathway_Homo sapiens_hsa043901.21558243
35Hypertrophic cardiomyopathy (HCM)_Homo sapiens_hsa054101.21068054
36Estrogen signaling pathway_Homo sapiens_hsa049151.20913896
37Nucleotide excision repair_Homo sapiens_hsa034201.20711515
38Sulfur metabolism_Homo sapiens_hsa009201.20029907
39TGF-beta signaling pathway_Homo sapiens_hsa043501.17207808
40Thyroid hormone signaling pathway_Homo sapiens_hsa049191.13363176
41Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030081.12624903
42Dilated cardiomyopathy_Homo sapiens_hsa054141.09094574
43SNARE interactions in vesicular transport_Homo sapiens_hsa041301.07965590
44Linoleic acid metabolism_Homo sapiens_hsa005911.07436660
45Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007601.07331525
46alpha-Linolenic acid metabolism_Homo sapiens_hsa005921.06827114
47p53 signaling pathway_Homo sapiens_hsa041151.04496464
48Transcriptional misregulation in cancer_Homo sapiens_hsa052021.04141291
49Vasopressin-regulated water reabsorption_Homo sapiens_hsa049621.03890093
50Prolactin signaling pathway_Homo sapiens_hsa049171.03806264
51Phototransduction_Homo sapiens_hsa047441.03342312
52Adrenergic signaling in cardiomyocytes_Homo sapiens_hsa042611.00706593
53Small cell lung cancer_Homo sapiens_hsa052220.99898898
54PI3K-Akt signaling pathway_Homo sapiens_hsa041510.99847484
55Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa005340.98094072
56Prostate cancer_Homo sapiens_hsa052150.96682850
57RNA polymerase_Homo sapiens_hsa030200.94912011
58cGMP-PKG signaling pathway_Homo sapiens_hsa040220.92634394
59Serotonergic synapse_Homo sapiens_hsa047260.92565804
60AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa049330.92521198
61MicroRNAs in cancer_Homo sapiens_hsa052060.92460101
62Pathways in cancer_Homo sapiens_hsa052000.91672304
63Longevity regulating pathway - mammal_Homo sapiens_hsa042110.88905178
64Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010400.88871631
65Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa045500.87783446
66Ubiquitin mediated proteolysis_Homo sapiens_hsa041200.86577330
67Insulin resistance_Homo sapiens_hsa049310.85945586
68Cytokine-cytokine receptor interaction_Homo sapiens_hsa040600.85600119
69Adherens junction_Homo sapiens_hsa045200.84347906
70Caffeine metabolism_Homo sapiens_hsa002320.82790878
71Renin secretion_Homo sapiens_hsa049240.82127342
72Synaptic vesicle cycle_Homo sapiens_hsa047210.80136935
73Ribosome_Homo sapiens_hsa030100.80018597
74Pyrimidine metabolism_Homo sapiens_hsa002400.78535924
75Ras signaling pathway_Homo sapiens_hsa040140.78257160
76Focal adhesion_Homo sapiens_hsa045100.77251655
77Glycerolipid metabolism_Homo sapiens_hsa005610.75907141
78Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa005200.75189080
79Rap1 signaling pathway_Homo sapiens_hsa040150.74838589
80Other types of O-glycan biosynthesis_Homo sapiens_hsa005140.74083196
81Autoimmune thyroid disease_Homo sapiens_hsa053200.72170156
82Jak-STAT signaling pathway_Homo sapiens_hsa046300.70062626
83Olfactory transduction_Homo sapiens_hsa047400.69565533
84Mineral absorption_Homo sapiens_hsa049780.69210504
85RNA degradation_Homo sapiens_hsa030180.68616805
86Cholinergic synapse_Homo sapiens_hsa047250.68570774
87Sphingolipid metabolism_Homo sapiens_hsa006000.66914653
88TNF signaling pathway_Homo sapiens_hsa046680.66389676
89Fructose and mannose metabolism_Homo sapiens_hsa000510.66158298
90Longevity regulating pathway - multiple species_Homo sapiens_hsa042130.65682786
91Base excision repair_Homo sapiens_hsa034100.64544892
92Tryptophan metabolism_Homo sapiens_hsa003800.64500064
93Tyrosine metabolism_Homo sapiens_hsa003500.63865979
94Melanogenesis_Homo sapiens_hsa049160.63432107
95Tight junction_Homo sapiens_hsa045300.61006661
96Regulation of actin cytoskeleton_Homo sapiens_hsa048100.60621141
97Endocytosis_Homo sapiens_hsa041440.59880864
98Colorectal cancer_Homo sapiens_hsa052100.58760265
99Thyroid cancer_Homo sapiens_hsa052160.57300953
100Arrhythmogenic right ventricular cardiomyopathy (ARVC)_Homo sapiens_hsa054120.57193993
101Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006010.55856656
102Thyroid hormone synthesis_Homo sapiens_hsa049180.55761734
103Retrograde endocannabinoid signaling_Homo sapiens_hsa047230.55590302
104Amyotrophic lateral sclerosis (ALS)_Homo sapiens_hsa050140.55358380
105Glioma_Homo sapiens_hsa052140.55049509
106Oxytocin signaling pathway_Homo sapiens_hsa049210.54434927
107Cell adhesion molecules (CAMs)_Homo sapiens_hsa045140.53966657
108Glycerophospholipid metabolism_Homo sapiens_hsa005640.52886359
109Platelet activation_Homo sapiens_hsa046110.52006446
110Long-term depression_Homo sapiens_hsa047300.51827301
111beta-Alanine metabolism_Homo sapiens_hsa004100.51407934
112Cyanoamino acid metabolism_Homo sapiens_hsa004600.51138301
113Protein processing in endoplasmic reticulum_Homo sapiens_hsa041410.50988254
114Lysosome_Homo sapiens_hsa041420.50956505
115Proteoglycans in cancer_Homo sapiens_hsa052050.50857007
116Phosphatidylinositol signaling system_Homo sapiens_hsa040700.49831359
117Phenylalanine metabolism_Homo sapiens_hsa003600.47368917
118cAMP signaling pathway_Homo sapiens_hsa040240.47359655
119Sphingolipid signaling pathway_Homo sapiens_hsa040710.46159502
120Glutamatergic synapse_Homo sapiens_hsa047240.46045035
121Protein digestion and absorption_Homo sapiens_hsa049740.45211333
122Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate_Homo sapiens_hsa005320.44033218
123Ether lipid metabolism_Homo sapiens_hsa005650.43388621
124Regulation of autophagy_Homo sapiens_hsa041400.43230331
125Phospholipase D signaling pathway_Homo sapiens_hsa040720.41577976
126Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa009700.40992947
127mTOR signaling pathway_Homo sapiens_hsa041500.40928406
128Non-small cell lung cancer_Homo sapiens_hsa052230.40740965
129PPAR signaling pathway_Homo sapiens_hsa033200.39647170
130Gastric acid secretion_Homo sapiens_hsa049710.39078395
131Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005630.38766566
132ErbB signaling pathway_Homo sapiens_hsa040120.37622027
133Calcium signaling pathway_Homo sapiens_hsa040200.37273037
134Amoebiasis_Homo sapiens_hsa051460.37188118
135Cell cycle_Homo sapiens_hsa041100.35898782
136Chronic myeloid leukemia_Homo sapiens_hsa052200.35289449
137Phagosome_Homo sapiens_hsa041450.34685303
138Other glycan degradation_Homo sapiens_hsa005110.34534300
139FoxO signaling pathway_Homo sapiens_hsa040680.33662856
140Circadian rhythm_Homo sapiens_hsa047100.33171104
141MAPK signaling pathway_Homo sapiens_hsa040100.32138649
142Arginine and proline metabolism_Homo sapiens_hsa003300.30900376
143Measles_Homo sapiens_hsa051620.30226782
144Hepatitis B_Homo sapiens_hsa051610.29784661
145Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa047500.28718181
146Taste transduction_Homo sapiens_hsa047420.28560871
147Fatty acid metabolism_Homo sapiens_hsa012120.28424423
148Pathogenic Escherichia coli infection_Homo sapiens_hsa051300.28075975
149Fanconi anemia pathway_Homo sapiens_hsa034600.25242322
150Vascular smooth muscle contraction_Homo sapiens_hsa042700.25146778
151Steroid hormone biosynthesis_Homo sapiens_hsa001400.25032079
152AMPK signaling pathway_Homo sapiens_hsa041520.24715920
153RIG-I-like receptor signaling pathway_Homo sapiens_hsa046220.21917931
154Histidine metabolism_Homo sapiens_hsa003400.20684323
155Bladder cancer_Homo sapiens_hsa052190.20632308
156Hematopoietic cell lineage_Homo sapiens_hsa046400.20501419

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