HOXD11

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: This gene belongs to the homeobox family of genes. The homeobox genes encode a highly conserved family of transcription factors that play an important role in morphogenesis in all multicellular organisms. Mammals possess four similar homeobox gene clusters, HOXA, HOXB, HOXC and HOXD, located on different chromosomes, consisting of 9 to 11 genes arranged in tandem. This gene is one of several homeobox HOXD genes located in a cluster on chromosome 2. Deletions that remove the entire HOXD gene cluster or the 5' end of this cluster have been associated with severe limb and genital abnormalities. The product of the mouse Hoxd11 gene plays a role in forelimb morphogenesis. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1mesenchymal to epithelial transition involved in metanephros morphogenesis (GO:0003337)8.14860504
2* proximal/distal pattern formation (GO:0009954)7.45932232
3mesenchymal cell differentiation involved in renal system development (GO:2001012)6.83926895
4mesenchymal cell differentiation involved in kidney development (GO:0072161)6.83926895
5metanephric mesenchyme development (GO:0072075)6.66133365
6kidney mesenchyme development (GO:0072074)6.52026337
7mesenchymal to epithelial transition (GO:0060231)6.20692386
8maturation of SSU-rRNA (GO:0030490)6.11740831
9* forelimb morphogenesis (GO:0035136)5.61018795
10* embryonic skeletal joint morphogenesis (GO:0060272)5.57136186
11outer ear morphogenesis (GO:0042473)5.38152761
12* embryonic forelimb morphogenesis (GO:0035115)5.36067326
13lymph vessel development (GO:0001945)5.35191085
14mesonephros development (GO:0001823)5.34580882
15regulation of mesenchymal cell apoptotic process (GO:2001053)5.25015223
16ribosomal small subunit biogenesis (GO:0042274)5.06288010
17* metanephros development (GO:0001656)4.77743837
18uterus development (GO:0060065)4.51049336
19regulation of cardioblast proliferation (GO:0003264)4.41793696
20regulation of secondary heart field cardioblast proliferation (GO:0003266)4.41793696
21thyroid gland development (GO:0030878)4.35424717
22regulation of single stranded viral RNA replication via double stranded DNA intermediate (GO:00450914.35017928
23* embryonic limb morphogenesis (GO:0030326)4.30742898
24* embryonic appendage morphogenesis (GO:0035113)4.30742898
25regulation of mammary gland epithelial cell proliferation (GO:0033599)4.26747973
26* embryonic skeletal system morphogenesis (GO:0048704)4.26543704
27peripheral nervous system neuron development (GO:0048935)4.24280011
28paraxial mesoderm development (GO:0048339)4.23994297
29* organ induction (GO:0001759)4.18929189
30middle ear morphogenesis (GO:0042474)4.14375406
31mesenchymal cell proliferation (GO:0010463)4.12766366
32chondrocyte proliferation (GO:0035988)4.10186847
33regulation of cardioblast differentiation (GO:0051890)4.09842102
34regulation of branching involved in prostate gland morphogenesis (GO:0060687)4.09432187
35* appendage morphogenesis (GO:0035107)4.08487467
36* limb morphogenesis (GO:0035108)4.08487467
37* embryonic digit morphogenesis (GO:0042733)4.01677549
38mesenchymal cell differentiation (GO:0048762)4.00963193
39DNA replication checkpoint (GO:0000076)3.99457166
40pattern specification involved in kidney development (GO:0061004)3.99065274
41hindlimb morphogenesis (GO:0035137)3.94513617
42* regulation of organ formation (GO:0003156)3.93300674
43cranial nerve morphogenesis (GO:0021602)3.92736105
44cell differentiation involved in kidney development (GO:0061005)3.90585013
45negative regulation of metanephros development (GO:0072217)3.89622314
46neural crest cell development (GO:0014032)3.89538957
47negative regulation of mesenchymal cell apoptotic process (GO:2001054)3.89078409
48negative regulation of mRNA splicing, via spliceosome (GO:0048025)3.88421069
49regulation of mesonephros development (GO:0061217)3.88197325
50outflow tract septum morphogenesis (GO:0003148)3.82532524
51lateral sprouting from an epithelium (GO:0060601)3.77778951
52planar cell polarity pathway involved in neural tube closure (GO:0090179)3.75141708
53cell differentiation involved in metanephros development (GO:0072202)3.73008126
54formation of translation preinitiation complex (GO:0001731)3.70932864
55heterochromatin organization (GO:0070828)3.70767407
56face development (GO:0060324)3.70752109
57regulation of mesenchymal to epithelial transition involved in metanephros morphogenesis (GO:00033393.63874053
58* branching involved in ureteric bud morphogenesis (GO:0001658)3.62760122
59positive regulation of mesonephros development (GO:0061213)3.62271240
60regulation of branching involved in ureteric bud morphogenesis (GO:0090189)3.61882884
61cochlea morphogenesis (GO:0090103)3.57099083
62* skeletal system morphogenesis (GO:0048705)3.56634657
63mesenchymal cell development (GO:0014031)3.51794586
64diterpenoid biosynthetic process (GO:0016102)3.51288796
65embryonic cranial skeleton morphogenesis (GO:0048701)3.50955889
66cell proliferation involved in metanephros development (GO:0072203)3.49276468
67* developmental induction (GO:0031128)3.47954168
68regulation of glomerulus development (GO:0090192)3.44760043
69* cell-cell signaling involved in cell fate commitment (GO:0045168)3.42969299
70viral transcription (GO:0019083)3.41878730
71embryonic digestive tract development (GO:0048566)3.39201456
72regulation of establishment of planar polarity involved in neural tube closure (GO:0090178)3.38623740
73branch elongation of an epithelium (GO:0060602)3.34880854
74muscle cell fate commitment (GO:0042693)3.34507933
75regulation of mitochondrial translation (GO:0070129)3.33290694
76mesenchyme development (GO:0060485)3.32090233
77cullin deneddylation (GO:0010388)3.30900630
78sympathetic nervous system development (GO:0048485)3.29697888
79positive regulation of metanephros development (GO:0072216)3.29154375
80translational termination (GO:0006415)3.28284711
81mitotic sister chromatid segregation (GO:0000070)3.27878521
82negative regulation of mRNA processing (GO:0050686)3.27769676
83DNA strand elongation involved in DNA replication (GO:0006271)3.26704170
84branching involved in prostate gland morphogenesis (GO:0060442)3.26029306
85positive regulation of branching involved in ureteric bud morphogenesis (GO:0090190)3.25788132
86nephron epithelium morphogenesis (GO:0072088)3.24975365
87nephron tubule morphogenesis (GO:0072078)3.24975365
88negative regulation of RNA splicing (GO:0033119)3.24464048
89midgut development (GO:0007494)3.22346571
90axis elongation (GO:0003401)3.21174285
91DNA strand elongation (GO:0022616)3.20558729
92craniofacial suture morphogenesis (GO:0097094)3.20044919
93glomerulus development (GO:0032835)3.19153135
94cell proliferation involved in kidney development (GO:0072111)3.17136203
95mesenchyme morphogenesis (GO:0072132)3.17123802
96regulation of heart morphogenesis (GO:2000826)3.17064399
97regulation of non-canonical Wnt signaling pathway (GO:2000050)3.16758169
98notochord development (GO:0030903)3.14254441
99lung-associated mesenchyme development (GO:0060484)3.14249605
100* anterior/posterior pattern specification (GO:0009952)3.13335965
101cranial nerve structural organization (GO:0021604)3.13260946
102DNA unwinding involved in DNA replication (GO:0006268)3.12544928
103* embryonic organ morphogenesis (GO:0048562)3.11005300
104negative regulation of kidney development (GO:0090185)3.08023165
105myoblast migration (GO:0051451)3.05970931
106short-term memory (GO:0007614)3.05682595
107G-protein coupled receptor signaling pathway coupled to cGMP nucleotide second messenger (GO:00071993.05573914
108eyelid development in camera-type eye (GO:0061029)3.04712396
109stem cell development (GO:0048864)3.04618821
110male genitalia development (GO:0030539)3.02980657
111protein localization to chromosome, centromeric region (GO:0071459)3.01068288
112ribonucleoprotein complex biogenesis (GO:0022613)2.98326168
113embryonic heart tube development (GO:0035050)2.98199211
114mitotic sister chromatid cohesion (GO:0007064)2.97808619
115appendage development (GO:0048736)2.97586700
116limb development (GO:0060173)2.97586700
117embryonic hindlimb morphogenesis (GO:0035116)2.97309294
118peptidyl-histidine modification (GO:0018202)2.97117202
119urogenital system development (GO:0001655)2.96695834
120nuclear-transcribed mRNA catabolic process, nonsense-mediated decay (GO:0000184)2.95916632
121nuclear pore organization (GO:0006999)2.95325341
122epithelial cell morphogenesis (GO:0003382)2.94097827
123kidney morphogenesis (GO:0060993)2.93884423
124protein deneddylation (GO:0000338)2.93536477
125diaphragm development (GO:0060539)2.93179314
126UTP biosynthetic process (GO:0006228)2.92060548
127DNA replication initiation (GO:0006270)2.91954466
128regulation of Wnt signaling pathway, planar cell polarity pathway (GO:2000095)2.91413840
129epithelial to mesenchymal transition involved in endocardial cushion formation (GO:0003198)2.90845326
130skeletal muscle organ development (GO:0060538)2.90570756
131mesenchymal-epithelial cell signaling (GO:0060638)2.89449162
132pyrimidine nucleoside triphosphate biosynthetic process (GO:0009148)2.89193919
133mesonephric tubule development (GO:0072164)2.89082825
134sister chromatid segregation (GO:0000819)2.88927720
135rRNA processing (GO:0006364)2.88793073
136regulation of metanephros development (GO:0072215)2.88731509
137pyrimidine ribonucleoside triphosphate biosynthetic process (GO:0009209)2.88537126
138protein localization to kinetochore (GO:0034501)2.88094594
139nuclear pore complex assembly (GO:0051292)2.87788154
140SRP-dependent cotranslational protein targeting to membrane (GO:0006614)2.87529754
141neuron fate specification (GO:0048665)2.86766787
142head development (GO:0060322)2.86498887
143telomere maintenance via semi-conservative replication (GO:0032201)2.83822432
144prostate epithelial cord arborization involved in prostate glandular acinus morphogenesis (GO:0060522.83731391
145coronary vasculature morphogenesis (GO:0060977)2.83582766
146translational elongation (GO:0006414)2.83367898
147guanosine-containing compound biosynthetic process (GO:1901070)2.81871900
148ribosomal large subunit biogenesis (GO:0042273)2.79355616
149morphogenesis of an epithelial fold (GO:0060571)2.78890787
150cotranslational protein targeting to membrane (GO:0006613)2.78081367
151regulation of apoptotic process involved in morphogenesis (GO:1902337)2.76885873
152translational initiation (GO:0006413)2.76142586
153regulation of translational fidelity (GO:0006450)2.75438813
154protein targeting to ER (GO:0045047)2.75086902
155pyrimidine nucleoside triphosphate metabolic process (GO:0009147)2.74535831
156rRNA metabolic process (GO:0016072)2.72035399
157mammary gland epithelial cell differentiation (GO:0060644)2.70559255
158muscle organ morphogenesis (GO:0048644)2.69795799
159regulation of chromatin binding (GO:0035561)2.69021674
160mitotic chromosome condensation (GO:0007076)2.68758331
161nucleobase-containing small molecule interconversion (GO:0015949)2.68078468
162CTP metabolic process (GO:0046036)2.67396776
163CTP biosynthetic process (GO:0006241)2.67396776
164mitotic G1 DNA damage checkpoint (GO:0031571)2.66749388
165pyrimidine ribonucleoside triphosphate metabolic process (GO:0009208)2.65876080
166aorta morphogenesis (GO:0035909)2.64561219
167establishment of protein localization to endoplasmic reticulum (GO:0072599)2.63746912
168pharyngeal system development (GO:0060037)2.62452476
169GTP biosynthetic process (GO:0006183)2.62405336
170UTP metabolic process (GO:0046051)2.61054597
171positive regulation of transcription regulatory region DNA binding (GO:2000679)2.60305304
172ventricular cardiac muscle cell development (GO:0055015)2.60284229
173negative regulation of mRNA metabolic process (GO:1903312)2.59934701
174termination of RNA polymerase II transcription (GO:0006369)2.58876563
175cardiac muscle cell proliferation (GO:0060038)2.58383086
176spliceosomal snRNP assembly (GO:0000387)2.56578692
177nuclear envelope reassembly (GO:0031468)2.56304104

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1TP63_19390658_ChIP-ChIP_HaCaT_Human4.26396974
2RBPJ_22232070_ChIP-Seq_NCS_Mouse3.97524812
3HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse3.93306568
4* EED_16625203_ChIP-ChIP_MESCs_Mouse3.69152816
5* PHC1_16625203_ChIP-ChIP_MESCs_Mouse3.45967484
6* CBX2_27304074_Chip-Seq_ESCs_Mouse3.45506942
7HCFC1_20581084_ChIP-Seq_MESCs_Mouse3.42533857
8* EZH2_27304074_Chip-Seq_ESCs_Mouse3.36199394
9* BMI1_23680149_ChIP-Seq_NPCS_Mouse3.35363125
10EKLF_21900194_ChIP-Seq_ERYTHROCYTE_Mouse3.21797792
11XRN2_22483619_ChIP-Seq_HELA_Human3.17413848
12E2F7_22180533_ChIP-Seq_HELA_Human3.06382256
13* JARID2_20064375_ChIP-Seq_MESCs_Mouse2.87113776
14* EZH2_18974828_ChIP-Seq_MESCs_Mouse2.85280616
15* RNF2_18974828_ChIP-Seq_MESCs_Mouse2.85280616
16CHD7_19251738_ChIP-ChIP_MESCs_Mouse2.82527621
17MYBL1_21750041_ChIP-ChIP_SPERMATOCYTES_Mouse2.80400944
18* JARID2_20075857_ChIP-Seq_MESCs_Mouse2.74563968
19* POU5F1_16153702_ChIP-ChIP_HESCs_Human2.74398687
20WT1_19549856_ChIP-ChIP_CCG9911_Human2.72196432
21* RNF2_16625203_ChIP-ChIP_MESCs_Mouse2.69596958
22MYC_18358816_ChIP-ChIP_MESCs_Mouse2.64885520
23JARID1A_20064375_ChIP-Seq_MESCs_Mouse2.60845780
24GLI1_17442700_ChIP-ChIP_MESCs_Mouse2.58454347
25* SUZ12_16625203_ChIP-ChIP_MESCs_Mouse2.55374506
26* SUZ12_18692474_ChIP-Seq_MEFs_Mouse2.52284485
27MYC_19030024_ChIP-ChIP_MESCs_Mouse2.49346703
28THAP11_20581084_ChIP-Seq_MESCs_Mouse2.48800393
29MYC_19079543_ChIP-ChIP_MESCs_Mouse2.47216796
30CREB1_15753290_ChIP-ChIP_HEK293T_Human2.45035362
31* TP53_20018659_ChIP-ChIP_R1E_Mouse2.44870854
32SALL1_21062744_ChIP-ChIP_HESCs_Human2.33838177
33ETS1_20019798_ChIP-Seq_JURKAT_Human2.29977284
34RNF2_27304074_Chip-Seq_NSC_Mouse2.29245435
35DCP1A_22483619_ChIP-Seq_HELA_Human2.16389739
36SUZ12_18555785_ChIP-Seq_MESCs_Mouse2.13927739
37* SUZ12_18974828_ChIP-Seq_MESCs_Mouse2.12446453
38KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human2.10860610
39EZH2_22144423_ChIP-Seq_EOC_Human2.08462144
40* SUZ12_18692474_ChIP-Seq_MESCs_Mouse2.07875732
41NOTCH1_17114293_ChIP-ChIP_T-ALL_Human2.05537824
42HOXD13_18407260_ChIP-ChIP_DEVELOPING-LIMBS_Mouse2.03425856
43E2F1_21310950_ChIP-Seq_MCF-7_Human1.97802370
44FUS_26573619_Chip-Seq_HEK293_Human1.97145434
45KLF5_18264089_ChIP-ChIP_MESCs_Mouse1.93336650
46KLF4_18264089_ChIP-ChIP_MESCs_Mouse1.93336650
47KLF2_18264089_ChIP-ChIP_MESCs_Mouse1.93336650
48POU5F1_18555785_ChIP-Seq_MESCs_Mouse1.92455153
49ZFP322A_24550733_ChIP-Seq_MESCs_Mouse1.89361506
50RNF2_27304074_Chip-Seq_ESCs_Mouse1.85200528
51CCND1_20090754_ChIP-ChIP_RETINA_Mouse1.83374484
52* RING1B_27294783_Chip-Seq_NPCs_Mouse1.82340926
53ZFX_18555785_ChIP-Seq_MESCs_Mouse1.77923290
54* KLF4_19030024_ChIP-ChIP_MESCs_Mouse1.77874378
55NELFA_20434984_ChIP-Seq_ESCs_Mouse1.77590318
56EST1_17652178_ChIP-ChIP_JURKAT_Human1.76186772
57PPARG_23326641_ChIP-Seq_C3H10T1-2_Mouse1.75093026
58ZFP281_18358816_ChIP-ChIP_MESCs_Mouse1.73297358
59GABP_19822575_ChIP-Seq_HepG2_Human1.72270543
60* WT1_20215353_ChIP-ChIP_NEPHRON_PROGENITOR_Mouse1.69940612
61CEBPD_23245923_ChIP-Seq_MEFs_Mouse1.68910826
62E2F1_18555785_ChIP-Seq_MESCs_Mouse1.67051409
63TBP_23326641_ChIP-Seq_C3H10T1-2_Mouse1.62356567
64CHD1_19587682_ChIP-ChIP_MESCs_Mouse1.62260025
65KDM5A_27292631_Chip-Seq_BREAST_Human1.60380655
66* EZH2_27294783_Chip-Seq_ESCs_Mouse1.60038565
67* EP300_20729851_ChIP-Seq_FORBRAIN_MIDBRAIN_LIMB_HEART_Mouse1.59046361
68YY1_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse1.58480183
69EWS_26573619_Chip-Seq_HEK293_Human1.55853211
70CNOT3_19339689_ChIP-ChIP_MESCs_Mouse1.55700493
71DACH1_20351289_ChIP-Seq_MDA-MB-231_Human1.54931069
72NR4A2_19515692_ChIP-ChIP_MN9D_Mouse1.53917725
73MYCN_18555785_ChIP-Seq_MESCs_Mouse1.53781053
74GABP_17652178_ChIP-ChIP_JURKAT_Human1.52021716
75SOX2_16153702_ChIP-ChIP_HESCs_Human1.51619835
76GBX2_23144817_ChIP-Seq_PC3_Human1.48787443
77CIITA_18437201_ChIP-ChIP_Raji_B_and_iDC_Human1.48414287
78* ZFP42_18358816_ChIP-ChIP_MESCs_Mouse1.47814633
79CREB1_23762244_ChIP-Seq_HIPPOCAMPUS_Rat1.45581251
80* SUZ12_27294783_Chip-Seq_ESCs_Mouse1.44376634
81FOXM1_23109430_ChIP-Seq_U2OS_Human1.43331603
82ESR1_15608294_ChIP-ChIP_MCF-7_Human1.42777115
83SOX9_22984422_ChIP-ChIP_TESTIS_Rat1.41026390
84E2F4_17652178_ChIP-ChIP_JURKAT_Human1.40178759
85ISL1_27105846_Chip-Seq_CPCs_Mouse1.39488867
86E2F4_21247883_ChIP-Seq_LYMPHOBLASTOID_Human1.35613654
87CTNNB1_24651522_ChIP-Seq_LGR5+_INTESTINAL_STEM_Human1.35387795
88ESR1_20079471_ChIP-ChIP_T-47D_Human1.35120387
89* KDM5B_21448134_ChIP-Seq_MESCs_Mouse1.34758326
90CDX2_19796622_ChIP-Seq_MESCs_Mouse1.34506702
91FOXM1_25889361_ChIP-Seq_OE33_AND_U2OS_Human1.34089176
92* TET1_21451524_ChIP-Seq_MESCs_Mouse1.30828862
93* RING1B_27294783_Chip-Seq_ESCs_Mouse1.27812378
94NANOG_18555785_ChIP-Seq_MESCs_Mouse1.26373662
95VDR_21846776_ChIP-Seq_THP-1_Human1.26293970
96TRIM28_17542650_ChIP-ChIP_NTERA2_Human1.26288422
97YY1_21170310_ChIP-Seq_MESCs_Mouse1.25698429
98TRIM28_19339689_ChIP-ChIP_MESCs_Mouse1.22690509
99BCL3_23251550_ChIP-Seq_MUSCLE_Mouse1.21511061
100EGR1_19374776_ChIP-ChIP_THP-1_Human1.17015844
101ZFP57_27257070_Chip-Seq_ESCs_Mouse1.16336093
102* MTF2_20144788_ChIP-Seq_MESCs_Mouse1.15629717
103SOX2_18555785_ChIP-Seq_MESCs_Mouse1.12660325
104CEBPB_24764292_ChIP-Seq_MC3T3_Mouse1.11988987
105POU5F1_18700969_ChIP-ChIP_MESCs_Mouse1.11988120
106CTBP2_25329375_ChIP-Seq_LNCAP_Human1.11969551
107* FOXM1_26100407_CHIP-SEQ_Hek293_flp-in_Human1.11619482
108CREB1_20920259_ChIP-Seq_GC1-SPG_Mouse1.11329159
109CREM_20920259_ChIP-Seq_GC1-SPG_Mouse1.10836382
110FOXP3_21729870_ChIP-Seq_TREG_Human1.08914311
111HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human1.07824105
112ELK3_25401928_ChIP-Seq_HUVEC_Human1.07133542
113FOXO3_22982991_ChIP-Seq_MACROPHAGES_Mouse1.07052711
114KLF4_18555785_ChIP-Seq_MESCs_Mouse1.06846717
115MYC_18940864_ChIP-ChIP_HL60_Human1.06429513
116CIITA_25753668_ChIP-Seq_RAJI_Human1.05834022
117MYC_22102868_ChIP-Seq_BL_Human1.04781939
118P300_19829295_ChIP-Seq_ESCs_Human1.03332292
119* NANOG_16153702_ChIP-ChIP_HESCs_Human1.02160289
120TP53_18474530_ChIP-ChIP_U2OS_Human1.02071532
121PRDM16_22522345_ChIP-ChIP_PALATE_MESENCHYMAL_Mouse1.01947293
122* POU5F1_18358816_ChIP-ChIP_MESCs_Mouse1.01771520
123EZH2_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse1.01474107
124PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human1.00618926
125ERG_20887958_ChIP-Seq_HPC-7_Mouse1.00299326
126RACK7_27058665_Chip-Seq_MCF-7_Human0.99318635
127PPARG_19300518_ChIP-PET_3T3-L1_Mouse0.98795906
128STAT3_19079543_ChIP-ChIP_MESCs_Mouse0.98273943
129TAL1_20887958_ChIP-Seq_HPC-7_Mouse0.98123629
130* MYBL2_22936984_ChIP-ChIP_MESCs_Mouse0.98064299
131MYCN_21190229_ChIP-Seq_SHEP-21N_Human0.97762978
132SA1_27219007_Chip-Seq_ERYTHROID_Human0.97697465
133CTCF_18555785_ChIP-Seq_MESCs_Mouse0.96871434
134TCF4_18268006_ChIP-ChIP_LS174T_Human0.96822623
135PIAS1_25552417_ChIP-Seq_VCAP_Human0.96623395
136CHD1_26751641_Chip-Seq_LNCaP_Human0.96506476
137CEBPD_21427703_ChIP-Seq_3T3-L1_Mouse0.94474904
138ESR1_22446102_ChIP-Seq_UTERUS_Mouse0.93614366
139TAF15_26573619_Chip-Seq_HEK293_Human0.93010751
140RARG_19884340_ChIP-ChIP_MEFs_Mouse0.92585036
141PDX1_19855005_ChIP-ChIP_MIN6_Mouse0.92248595
142TEAD4_26923725_Chip-Seq_HEMANGIOBLAST_Mouse0.91620785
143POU5F1_26923725_Chip-Seq_MESODERM_Mouse0.91620785
144SMAD3_21741376_ChIP-Seq_EPCs_Human0.91403417
145ZFP281_18757296_ChIP-ChIP_E14_Mouse0.88887410
146SOX9_26525672_Chip-Seq_HEART_Mouse0.86129667
147ZNF274_21170338_ChIP-Seq_K562_Hela0.84305810
148CEBPB_26923725_Chip-Seq_MESODERM_Mouse0.84243216
149CDX2_20551321_ChIP-Seq_CACO-2_Human0.83243643
150AR_21909140_ChIP-Seq_LNCAP_Human0.81612646
151SMAD2/3_21741376_ChIP-Seq_EPCs_Human0.81493764
152SOX9_26525672_Chip-Seq_Limbbuds_Mouse0.79186457
153TCF3_18467660_ChIP-ChIP_MESCs_Mouse0.78930639
154TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat0.78753662
155POU3F2_20337985_ChIP-ChIP_501MEL_Human0.78452591
156VDR_22108803_ChIP-Seq_LS180_Human0.78206306
157* ZFP281_27345836_Chip-Seq_ESCs_Mouse0.76408166
158* SUZ12_20075857_ChIP-Seq_MESCs_Mouse0.75939299
159CTBP1_25329375_ChIP-Seq_LNCAP_Human0.75641968
160TOP2B_26459242_ChIP-Seq_MCF-7_Human0.75497144
161MYC_18555785_ChIP-Seq_MESCs_Mouse0.75371248
162ARNT_22903824_ChIP-Seq_MCF-7_Human0.73096662
163* WT1_25993318_ChIP-Seq_PODOCYTE_Human0.72783138
164TRIM28_21343339_ChIP-Seq_HEK293_Human0.72728701
165* TTF2_22483619_ChIP-Seq_HELA_Human0.72721842

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0009053_abnormal_anal_canal4.73114953
2MP0003942_abnormal_urinary_system3.81973069
3MP0003123_paternal_imprinting3.69401330
4MP0003385_abnormal_body_wall3.39774298
5MP0005503_abnormal_tendon_morphology3.33938314
6MP0003315_abnormal_perineum_morphology3.29313572
7MP0003122_maternal_imprinting3.19448715
8MP0010030_abnormal_orbit_morphology3.19061841
9MP0000537_abnormal_urethra_morphology3.09927366
10* MP0009250_abnormal_appendicular_skeleto3.09256149
11MP0000534_abnormal_ureter_morphology2.94438539
12MP0003937_abnormal_limbs/digits/tail_de2.77023415
13MP0002249_abnormal_larynx_morphology2.74842311
14MP0003121_genomic_imprinting2.62710348
15MP0000049_abnormal_middle_ear2.51168176
16MP0003938_abnormal_ear_development2.46309379
17MP0000516_abnormal_urinary_system2.42942478
18MP0005367_renal/urinary_system_phenotyp2.42942478
19MP0010094_abnormal_chromosome_stability2.35463452
20MP0002234_abnormal_pharynx_morphology2.30671082
21MP0002932_abnormal_joint_morphology2.28398435
22MP0003077_abnormal_cell_cycle2.28083168
23MP0000566_synostosis2.27832542
24MP0003941_abnormal_skin_development2.27765925
25MP0003693_abnormal_embryo_hatching2.23272860
26MP0002877_abnormal_melanocyte_morpholog2.17552942
27MP0002282_abnormal_trachea_morphology2.03640056
28MP0008058_abnormal_DNA_repair1.99571541
29MP0003705_abnormal_hypodermis_morpholog1.96275500
30MP0008057_abnormal_DNA_replication1.95636353
31* MP0002109_abnormal_limb_morphology1.79782566
32MP0005187_abnormal_penis_morphology1.75893456
33MP0003755_abnormal_palate_morphology1.70766344
34MP0005623_abnormal_meninges_morphology1.66796071
35* MP0002114_abnormal_axial_skeleton1.64391647
36MP0002160_abnormal_reproductive_system1.58828781
37MP0000350_abnormal_cell_proliferation1.57684874
38MP0002938_white_spotting1.57089288
39* MP0002115_abnormal_skeleton_extremities1.54968740
40MP0000428_abnormal_craniofacial_morphol1.52030481
41MP0005409_darkened_coat_color1.51735236
42MP0000681_abnormal_thyroid_gland1.50504467
43MP0002233_abnormal_nose_morphology1.49699440
44MP0002163_abnormal_gland_morphology1.45353033
45MP0003787_abnormal_imprinting1.44647182
46MP0004272_abnormal_basement_membrane1.43377209
47MP0004233_abnormal_muscle_weight1.43190026
48MP0005508_abnormal_skeleton_morphology1.42984515
49MP0002177_abnormal_outer_ear1.38289479
50MP0002116_abnormal_craniofacial_bone1.38187264
51MP0005248_abnormal_Harderian_gland1.34203693
52MP0000003_abnormal_adipose_tissue1.33379789
53MP0003935_abnormal_craniofacial_develop1.33302015
54MP0003115_abnormal_respiratory_system1.32936740
55MP0000678_abnormal_parathyroid_gland1.31995559
56MP0002111_abnormal_tail_morphology1.28787427
57MP0002751_abnormal_autonomic_nervous1.28623593
58MP0003136_yellow_coat_color1.26058286
59MP0006292_abnormal_olfactory_placode1.25594456
60MP0001730_embryonic_growth_arrest1.23092414
61MP0000163_abnormal_cartilage_morphology1.20528984
62MP0010307_abnormal_tumor_latency1.18134809
63MP0000432_abnormal_head_morphology1.13971783
64MP0005275_abnormal_skin_tensile1.12562404
65MP0005389_reproductive_system_phenotype1.12207655
66MP0000759_abnormal_skeletal_muscle1.08712579
67MP0003786_premature_aging1.06204059
68MP0008789_abnormal_olfactory_epithelium1.04636186
69* MP0005380_embryogenesis_phenotype1.04153037
70* MP0001672_abnormal_embryogenesis/_devel1.04153037
71MP0003119_abnormal_digestive_system1.02920281
72MP0003567_abnormal_fetal_cardiomyocyte1.01659651
73MP0003984_embryonic_growth_retardation1.00781157
74MP0001286_abnormal_eye_development0.99945614
75MP0004134_abnormal_chest_morphology0.98780895
76MP0001879_abnormal_lymphatic_vessel0.98595869
77MP0000762_abnormal_tongue_morphology0.97805152
78MP0002113_abnormal_skeleton_development0.97098309
79MP0003936_abnormal_reproductive_system0.95889764
80* MP0002085_abnormal_embryonic_tissue0.95744359
81MP0001346_abnormal_lacrimal_gland0.95017769
82MP0001697_abnormal_embryo_size0.94212930
83MP0008932_abnormal_embryonic_tissue0.93639694
84MP0001188_hyperpigmentation0.92937428
85MP0002088_abnormal_embryonic_growth/wei0.92469508
86* MP0003861_abnormal_nervous_system0.92430243
87MP0002277_abnormal_respiratory_mucosa0.88842088
88MP0002081_perinatal_lethality0.87859174
89MP0003283_abnormal_digestive_organ0.87499018
90MP0001340_abnormal_eyelid_morphology0.87096182
91MP0000313_abnormal_cell_death0.86584037
92MP0001919_abnormal_reproductive_system0.86057402
93MP0002102_abnormal_ear_morphology0.83901861
94MP0004858_abnormal_nervous_system0.83051889
95MP0000026_abnormal_inner_ear0.82368500
96MP0002108_abnormal_muscle_morphology0.82367797
97MP0000778_abnormal_nervous_system0.81588296
98MP0005257_abnormal_intraocular_pressure0.81045518
99MP0000631_abnormal_neuroendocrine_gland0.80738830
100MP0002697_abnormal_eye_size0.80642050
101MP0000767_abnormal_smooth_muscle0.79594403
102MP0000733_abnormal_muscle_development0.79231081
103MP0000372_irregular_coat_pigmentation0.78712705
104* MP0002080_prenatal_lethality0.78153767
105MP0001299_abnormal_eye_distance/0.77357110
106MP0001849_ear_inflammation0.77081848
107MP0001270_distended_abdomen0.76590957
108MP0008438_abnormal_cutaneous_collagen0.76386831
109MP0001661_extended_life_span0.76154810
110MP0004185_abnormal_adipocyte_glucose0.75871085
111MP0004133_heterotaxia0.75632799
112MP0002184_abnormal_innervation0.74938476
113MP0000538_abnormal_urinary_bladder0.74174802
114MP0008007_abnormal_cellular_replicative0.73757378
115MP0010352_gastrointestinal_tract_polyps0.72995440
116MP0001293_anophthalmia0.72766361
117MP0002084_abnormal_developmental_patter0.70749682
118MP0004197_abnormal_fetal_growth/weight/0.70568389
119MP0000955_abnormal_spinal_cord0.69406752
120MP0003111_abnormal_nucleus_morphology0.67709668
121MP0005499_abnormal_olfactory_system0.67094610
122MP0005394_taste/olfaction_phenotype0.67094610
123MP0005076_abnormal_cell_differentiation0.67005242
124MP0005197_abnormal_uvea_morphology0.66600550
125MP0002092_abnormal_eye_morphology0.65467983
126MP0001177_atelectasis0.63752145
127MP0002135_abnormal_kidney_morphology0.63118545
128MP0009672_abnormal_birth_weight0.61643438
129MP0009703_decreased_birth_body0.61602728
130MP0001119_abnormal_female_reproductive0.60393666
131MP0009379_abnormal_foot_pigmentation0.59902000
132MP0002009_preneoplasia0.59747476
133MP0004957_abnormal_blastocyst_morpholog0.59650098
134MP0000467_abnormal_esophagus_morphology0.59523040
135MP0000613_abnormal_salivary_gland0.58964306

Predicted human phenotypes

RankGene SetZ-score
1Short middle phalanx of the 5th finger (HP:0004220)4.20615140
2Abnormality of the phalanges of the hallux (HP:0010057)4.10641762
3Congenital malformation of the right heart (HP:0011723)4.10289054
4Double outlet right ventricle (HP:0001719)4.10289054
5Abnormal number of incisors (HP:0011064)3.86885181
6Septate vagina (HP:0001153)3.80796252
7Preauricular pit (HP:0004467)3.61662781
8Periauricular skin pits (HP:0100277)3.61662781
9Nephroblastoma (Wilms tumor) (HP:0002667)3.46646745
10Embryonal renal neoplasm (HP:0011794)3.34751260
11Mesomelia (HP:0003027)3.33969506
12Asymmetry of the thorax (HP:0001555)3.31880476
13Cutaneous finger syndactyly (HP:0010554)3.31038113
14Renal dysplasia (HP:0000110)3.28831457
15Abnormality of the umbilical cord (HP:0010881)3.26092720
16Abnormality of the 4th metacarpal (HP:0010012)3.23947005
17Birth length less than 3rd percentile (HP:0003561)3.23680377
18Renal duplication (HP:0000075)3.23535615
19Short 5th finger (HP:0009237)3.20931282
20Aplasia/Hypoplasia of the middle phalanx of the 5th finger (HP:0009161)3.19107261
21Morphological abnormality of the middle ear (HP:0008609)3.18254162
22Aplasia/Hypoplasia of the sacrum (HP:0008517)3.12984637
23Calcaneovalgus deformity (HP:0001848)3.08470161
24Abnormality of the distal phalanges of the toes (HP:0010182)3.05714857
25Deformed tarsal bones (HP:0008119)3.05138387
26Midline defect of the nose (HP:0004122)3.04831271
27Cutaneous syndactyly (HP:0012725)3.03982738
28Aplasia/Hypoplasia of the 5th finger (HP:0006262)3.02948527
29Selective tooth agenesis (HP:0001592)2.97843440
30Abnormal lung lobation (HP:0002101)2.95358463
31Microretrognathia (HP:0000308)2.94323423
32Aplasia/Hypoplasia of the phalanges of the 5th finger (HP:0009376)2.93791599
33Abnormality of the nasolacrimal system (HP:0000614)2.93186140
34Broad distal phalanx of finger (HP:0009836)2.92651785
35Abnormality of the middle phalanx of the 5th finger (HP:0004219)2.91838030
36Partial duplication of the phalanx of hand (HP:0009999)2.86869613
37Abnormality of the aortic arch (HP:0012303)2.84935430
38Broad thumb (HP:0011304)2.81062782
39Hepatoblastoma (HP:0002884)2.77569441
40Abnormality of the lacrimal duct (HP:0011481)2.76644052
41Short clavicles (HP:0000894)2.75073760
42Abnormality of the phalanges of the 5th finger (HP:0004213)2.72086693
43Unilateral renal agenesis (HP:0000122)2.71920996
44Abnormality of the middle phalanges of the toes (HP:0010183)2.71334821
45Abnormality of the 2nd finger (HP:0004100)2.69861671
46Aplasia/Hypoplasia of the clavicles (HP:0006710)2.69113324
47Breast hypoplasia (HP:0003187)2.67610316
48Renal hypoplasia (HP:0000089)2.67205174
49Premature rupture of membranes (HP:0001788)2.66177372
50Bifid tongue (HP:0010297)2.63782923
51Broad toe (HP:0001837)2.62660537
52Short 4th metacarpal (HP:0010044)2.59936120
53Aplasia/Hypoplasia of the 4th metacarpal (HP:0010042)2.59936120
54Reticulocytopenia (HP:0001896)2.57547164
55Diastasis recti (HP:0001540)2.54420640
56Skin pits (HP:0100276)2.50974239
57Short middle phalanx of finger (HP:0005819)2.48370402
58Abnormality of the distal phalanx of the thumb (HP:0009617)2.47419272
59Hypoplastic left heart (HP:0004383)2.46991447
60Symphalangism affecting the phalanges of the hand (HP:0009773)2.44292291
61Aplastic anemia (HP:0001915)2.44136403
62Syringomyelia (HP:0003396)2.40891194
63Spinal cord lesions (HP:0100561)2.40891194
64Fibular aplasia (HP:0002990)2.38931367
65Atresia of the external auditory canal (HP:0000413)2.38397785
66Broad phalanges of the hand (HP:0009768)2.37723344
67Absent phalangeal crease (HP:0006109)2.36938237
68Carpal synostosis (HP:0009702)2.35405676
69Broad finger (HP:0001500)2.35276874
70Rectal prolapse (HP:0002035)2.33913574
71Lip pit (HP:0100267)2.30134721
72Aplasia/Hypoplasia of the 1st metacarpal (HP:0010026)2.30024327
73Short 1st metacarpal (HP:0010034)2.30024327
74Ulnar bowing (HP:0003031)2.29608299
75Truncus arteriosus (HP:0001660)2.28496386
76Abnormality of the phalanges of the 2nd finger (HP:0009541)2.27441133
77Intestinal fistula (HP:0100819)2.27041691
78Broad phalanx (HP:0006009)2.26937264
79Abnormality of the parietal bone (HP:0002696)2.26804302
80Myelomeningocele (HP:0002475)2.26317593
81Rectal fistula (HP:0100590)2.24232087
82Rectovaginal fistula (HP:0000143)2.24232087
83Transposition of the great arteries (HP:0001669)2.21022774
84Abnormal connection of the cardiac segments (HP:0011545)2.21022774
85Abnormal ventriculo-arterial connection (HP:0011563)2.21022774
86Pulmonary artery stenosis (HP:0004415)2.18959098
87Abnormality of the intervertebral disk (HP:0005108)2.18524884
88Chromosomal breakage induced by crosslinking agents (HP:0003221)2.18267583
89Coronal craniosynostosis (HP:0004440)2.18189388
90Fibular hypoplasia (HP:0003038)2.17520085
91Bicornuate uterus (HP:0000813)2.17140185
92Preauricular skin tag (HP:0000384)2.15778400
93Anophthalmia (HP:0000528)2.15716948
94Broad long bones (HP:0005622)2.15173670
95Preaxial foot polydactyly (HP:0001841)2.14548663
96Ureteral stenosis (HP:0000071)2.13591128
97Synostosis involving bones of the hand (HP:0004278)2.13373837
98Ureteral duplication (HP:0000073)2.13331985
99Shallow orbits (HP:0000586)2.12911772
100Abnormal finger flexion creases (HP:0006143)2.12525278
101Anal atresia (HP:0002023)2.10992523
102Ureteral obstruction (HP:0006000)2.09730776
103Chromsome breakage (HP:0040012)2.09717977
104Ectopic kidney (HP:0000086)2.09011587
105Omphalocele (HP:0001539)2.08912078
106Partial duplication of thumb phalanx (HP:0009944)2.08649213
107Synostosis of carpal bones (HP:0005048)2.08040562
108Occipital encephalocele (HP:0002085)2.04810316
109Anomalous pulmonary venous return (HP:0010772)2.04434743
110Short hallux (HP:0010109)2.04429359
111Abnormality of the calcaneus (HP:0008364)2.02968515
112Abnormality of the nasal septum (HP:0000419)2.02914592
113Short tibia (HP:0005736)2.02209643
114Optic nerve coloboma (HP:0000588)2.02016246
115Supernumerary spleens (HP:0009799)2.00964733
116Abnormality of chromosome segregation (HP:0002916)2.00749316
117Aplasia/Hypoplasia of the fibula (HP:0006492)1.99619701
118Down-sloping shoulders (HP:0200021)1.98343505
119Proximal placement of thumb (HP:0009623)1.97978827
120Reduced subcutaneous adipose tissue (HP:0003758)1.97847908
121Abnormality of the ischium (HP:0003174)1.96946789
122Abnormal umbilical cord blood vessels (HP:0011403)1.96714602
123Single umbilical artery (HP:0001195)1.96714602
124Abnormality of the fetal cardiovascular system (HP:0010948)1.96714602
125Absent radius (HP:0003974)1.96684927
126Abnormality of the 1st metacarpal (HP:0010009)1.96390501
127Abnormality of the pulmonary veins (HP:0011718)1.95987647
128Bilateral microphthalmos (HP:0007633)1.95393613
129Nasolacrimal duct obstruction (HP:0000579)1.95073667
130Abnormalities of placenta or umbilical cord (HP:0001194)1.94625318
131Microglossia (HP:0000171)1.94112771
132Vaginal fistula (HP:0004320)1.93794488
133Hypoplastic heart (HP:0001961)1.91916154
134Synostosis involving bones of the feet (HP:0009140)1.91687944
135Synostosis involving bones of the lower limbs (HP:0009138)1.91687944
136Genu recurvatum (HP:0002816)1.91039753
137Aplasia/Hypoplasia of the tibia (HP:0005772)1.90475546
138Cutaneous melanoma (HP:0012056)1.89803250
139Aplasia/Hypoplasia of the middle phalanges of the hand (HP:0009843)1.89076735
140Self-mutilation (HP:0000742)1.87613158
141Duplication of thumb phalanx (HP:0009942)1.86218295
142Absent eyebrow (HP:0002223)1.85904148
143Deviation of the hallux (HP:0010051)1.85657550
144Sparse lateral eyebrow (HP:0005338)1.85548387
145Macrocytic anemia (HP:0001972)1.84734724
146Skin tags (HP:0010609)1.84277405
147Natal tooth (HP:0000695)1.83349305
148High anterior hairline (HP:0009890)1.82902259
149Protrusio acetabuli (HP:0003179)1.82673647
150Recurrent corneal erosions (HP:0000495)1.82501341
151Radial bowing (HP:0002986)1.82100110
152Progressive muscle weakness (HP:0003323)1.80553658
153Absent forearm bone (HP:0003953)1.80043483
154Aplasia involving forearm bones (HP:0009822)1.80043483
155Deviation of the thumb (HP:0009603)1.72995181
156Patent foramen ovale (HP:0001655)1.69343794
157Short thumb (HP:0009778)1.69204984
158Abnormality of cells of the erythroid lineage (HP:0012130)1.69119808
159Triphalangeal thumb (HP:0001199)1.68736129
160Hallux valgus (HP:0001822)1.67763043
161Aplasia/Hypoplasia of the patella (HP:0006498)1.67681382
162Fragile skin (HP:0001030)1.67420648
163Esophageal atresia (HP:0002032)1.67251129
164Facial cleft (HP:0002006)1.66665351
165Slender long bone (HP:0003100)1.65695280
166Degeneration of anterior horn cells (HP:0002398)1.65428492
167Abnormality of the anterior horn cell (HP:0006802)1.65428492
168Patellar aplasia (HP:0006443)1.63868003
169Hydroureter (HP:0000072)1.63379740
170Squamous cell carcinoma (HP:0002860)1.63249754
171Trismus (HP:0000211)1.62821730

Predicted kinase interactions (KEA)

RankGene SetZ-score
1MKNK25.28484487
2MKNK15.21713364
3CASK4.66143188
4CDK123.70016914
5SMG13.59991669
6IRAK33.17699705
7SRPK13.11693134
8NME23.07850286
9VRK23.03406851
10LATS13.03182728
11TRIB32.98704410
12LATS22.65742108
13EEF2K2.61452651
14PDK22.56705542
15TLK12.43872098
16ARAF2.40305550
17ERBB32.35868241
18EPHB22.35518049
19ICK2.16664739
20CAMK1G2.02415673
21CDC71.93868536
22TAF11.89181375
23STK38L1.77828705
24PRPF4B1.75722944
25MAPK131.73790894
26WNK11.70427573
27PNCK1.68616733
28DDR21.68503843
29NEK91.55636045
30PASK1.53152475
31BUB11.51369188
32YES11.44672446
33MAP3K101.44300060
34CDK81.42570348
35PLK31.39412405
36TAOK21.38827985
37FER1.38522364
38CSNK1G31.36217285
39CAMK1D1.35151767
40IRAK21.34666584
41AKT31.32465691
42WNK41.30501133
43NME11.30411649
44KDR1.25242961
45PLK21.23714379
46PLK41.22811427
47LIMK11.21805235
48NEK11.20500339
49CDK41.20042321
50BRSK11.16982696
51PBK1.14853649
52CDK71.13118334
53CSNK1G11.12282781
54PIM21.09377372
55PRKD31.08229338
56FGFR21.05989991
57ILK1.02092357
58FRK1.00287674
59PDGFRA0.99266763
60TSSK60.96839523
61CDK90.94222748
62UHMK10.93758519
63TGFBR10.90420468
64CLK10.89684308
65BCKDK0.86975898
66PLK10.84752620
67FGFR10.83875269
68STK40.81660606
69BRAF0.81383477
70ZAK0.81253233
71STK30.79215103
72DYRK20.79015989
73CSNK1G20.78950618
74VRK10.78754601
75MTOR0.77718748
76BCR0.76090691
77NUAK10.76058789
78DYRK30.75577762
79MAPKAPK50.73566517
80MAP2K70.72513663
81EIF2AK10.70727488
82BRD40.69556900
83BRSK20.69365869
84CDK30.67880297
85PAK20.67136710
86SGK20.66731750
87MOS0.66047020
88MAPK110.64142013
89PIK3CA0.63181683
90IRAK40.62997486
91EIF2AK20.62810801
92PIK3CG0.61106541
93AURKB0.60763053
94EPHA40.60264867
95AKT20.59948243
96ATR0.59758632
97TTK0.58187199
98WEE10.57662216
99CDK10.57133734
100TNK20.56885046
101CSNK1A1L0.56290613
102MAP3K80.55641420
103PTK60.55288858
104RPS6KA50.55022580
105LRRK20.54462450
106STK390.53928629
107RPS6KA20.52601224
108CSNK1E0.52560764
109ADRBK10.52377277
110MELK0.52082011
111CDK11A0.51303016
112CHEK10.51013595
113ROCK20.50781660
114RPS6KB20.50317319
115CSNK2A10.48813091
116CDK150.48744980
117PKN10.48656677
118CHEK20.48002773
119AURKA0.47406770
120INSRR0.47034087
121RAF10.46634873
122MYLK0.45699528
123NEK60.45680657
124CDC42BPA0.44671041
125STK160.44553865
126TTN0.44397064
127ABL20.44346297
128CDK20.43585715
129SGK2230.43547714
130SGK4940.43547714
131DMPK0.42947657
132RPS6KA60.42665364
133CDK180.42521214
134RPS6KL10.42330936
135RPS6KC10.42330936
136ALK0.41295308
137MAP2K30.40482247
138NTRK30.39795197
139RPS6KA40.39522495
140AKT10.39442963
141ATM0.38796283
142BMX0.38742203
143PRKDC0.38061324
144DYRK1A0.37752812
145CDK60.37728888
146MAPK140.36882344
147PTK20.36624370
148BMPR20.36522643
149MAP2K20.35782607
150PRKCI0.35054443
151MAPK80.34400542
152PAK40.33716222
153DAPK10.33135528
154KSR20.33089641
155BLK0.31972602
156CAMKK20.31944111
157MAP3K90.31753917

Predicted pathways (KEGG)

RankGene SetZ-score
1Basal cell carcinoma_Homo sapiens_hsa052174.06885670
2Sulfur relay system_Homo sapiens_hsa041223.67323156
3Hedgehog signaling pathway_Homo sapiens_hsa043403.31007218
4Spliceosome_Homo sapiens_hsa030402.70607919
5Hippo signaling pathway_Homo sapiens_hsa043902.70547391
6Homologous recombination_Homo sapiens_hsa034402.34648959
7Cell cycle_Homo sapiens_hsa041102.31675685
8Wnt signaling pathway_Homo sapiens_hsa043102.21580398
9Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa045502.15225301
10TGF-beta signaling pathway_Homo sapiens_hsa043502.12253692
11Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa009702.12158726
12Vitamin B6 metabolism_Homo sapiens_hsa007502.07167851
13Ribosome_Homo sapiens_hsa030102.02302038
14Axon guidance_Homo sapiens_hsa043602.00388814
15Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006031.92191184
16Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001301.87609110
17MicroRNAs in cancer_Homo sapiens_hsa052061.85762982
18Melanoma_Homo sapiens_hsa052181.76613313
19Melanogenesis_Homo sapiens_hsa049161.73780897
20mRNA surveillance pathway_Homo sapiens_hsa030151.72572459
21Fanconi anemia pathway_Homo sapiens_hsa034601.70284085
22Nucleotide excision repair_Homo sapiens_hsa034201.69790203
23Ubiquitin mediated proteolysis_Homo sapiens_hsa041201.67801492
24RNA transport_Homo sapiens_hsa030131.65942765
25Transcriptional misregulation in cancer_Homo sapiens_hsa052021.61978125
26Basal transcription factors_Homo sapiens_hsa030221.61230461
27Base excision repair_Homo sapiens_hsa034101.49756386
28Mismatch repair_Homo sapiens_hsa034301.49562603
29Thyroid cancer_Homo sapiens_hsa052161.47310240
30RNA degradation_Homo sapiens_hsa030181.43690708
31RNA polymerase_Homo sapiens_hsa030201.41330767
32DNA replication_Homo sapiens_hsa030301.40205783
33Prostate cancer_Homo sapiens_hsa052151.39419087
34Cysteine and methionine metabolism_Homo sapiens_hsa002701.35608561
35Proteoglycans in cancer_Homo sapiens_hsa052051.34481765
36Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005121.32964499
37Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa005341.29690505
38Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006011.27320058
39Pathways in cancer_Homo sapiens_hsa052001.26985633
40Citrate cycle (TCA cycle)_Homo sapiens_hsa000201.26206851
41Parkinsons disease_Homo sapiens_hsa050121.24880784
42Oxidative phosphorylation_Homo sapiens_hsa001901.20343621
43Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005331.19600598
44Proteasome_Homo sapiens_hsa030501.17638005
45Biosynthesis of amino acids_Homo sapiens_hsa012301.14755835
46Taurine and hypotaurine metabolism_Homo sapiens_hsa004301.14161823
47Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030081.12157191
48Selenocompound metabolism_Homo sapiens_hsa004501.11380791
49Adherens junction_Homo sapiens_hsa045201.10467179
50Arrhythmogenic right ventricular cardiomyopathy (ARVC)_Homo sapiens_hsa054121.09055657
51Folate biosynthesis_Homo sapiens_hsa007901.06717583
52HTLV-I infection_Homo sapiens_hsa051661.05925313
53Non-homologous end-joining_Homo sapiens_hsa034501.05902021
54Bladder cancer_Homo sapiens_hsa052191.05226310
55ECM-receptor interaction_Homo sapiens_hsa045121.04888102
56PI3K-Akt signaling pathway_Homo sapiens_hsa041510.99811563
57Focal adhesion_Homo sapiens_hsa045100.99182516
58Arachidonic acid metabolism_Homo sapiens_hsa005900.98808534
59Tight junction_Homo sapiens_hsa045300.96550303
60Longevity regulating pathway - multiple species_Homo sapiens_hsa042130.96105317
61Rap1 signaling pathway_Homo sapiens_hsa040150.93619778
62Small cell lung cancer_Homo sapiens_hsa052220.93265409
63Protein export_Homo sapiens_hsa030600.93134970
64Oocyte meiosis_Homo sapiens_hsa041140.92629240
65Colorectal cancer_Homo sapiens_hsa052100.91368083
66Notch signaling pathway_Homo sapiens_hsa043300.90584477
67Cyanoamino acid metabolism_Homo sapiens_hsa004600.89430076
68Endometrial cancer_Homo sapiens_hsa052130.89156196
69Progesterone-mediated oocyte maturation_Homo sapiens_hsa049140.85745706
70Longevity regulating pathway - mammal_Homo sapiens_hsa042110.81758566
71Glioma_Homo sapiens_hsa052140.80276241
72p53 signaling pathway_Homo sapiens_hsa041150.78030690
73Central carbon metabolism in cancer_Homo sapiens_hsa052300.76268820
74Purine metabolism_Homo sapiens_hsa002300.75973255
75Alzheimers disease_Homo sapiens_hsa050100.75430613
76Pyrimidine metabolism_Homo sapiens_hsa002400.75196502
77Phototransduction_Homo sapiens_hsa047440.74295893
78Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate_Homo sapiens_hsa005320.70726834
79Sulfur metabolism_Homo sapiens_hsa009200.70693598
80Neuroactive ligand-receptor interaction_Homo sapiens_hsa040800.69296823
812-Oxocarboxylic acid metabolism_Homo sapiens_hsa012100.67158040
82Gap junction_Homo sapiens_hsa045400.66672343
83Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049320.65867405
84Protein processing in endoplasmic reticulum_Homo sapiens_hsa041410.65866929
85Ras signaling pathway_Homo sapiens_hsa040140.65191605
86Dilated cardiomyopathy_Homo sapiens_hsa054140.64909162
87Regulation of actin cytoskeleton_Homo sapiens_hsa048100.62442541
88Fructose and mannose metabolism_Homo sapiens_hsa000510.59085112
89Galactose metabolism_Homo sapiens_hsa000520.58552121
90Hypertrophic cardiomyopathy (HCM)_Homo sapiens_hsa054100.58059712
91Fatty acid elongation_Homo sapiens_hsa000620.57145398
92Carbon metabolism_Homo sapiens_hsa012000.56714491
93Arginine and proline metabolism_Homo sapiens_hsa003300.56282274
94Retinol metabolism_Homo sapiens_hsa008300.54169880
95Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa005200.53588583
96Vibrio cholerae infection_Homo sapiens_hsa051100.52791335
97Chronic myeloid leukemia_Homo sapiens_hsa052200.52007258
98Pentose phosphate pathway_Homo sapiens_hsa000300.51962957
99Cell adhesion molecules (CAMs)_Homo sapiens_hsa045140.51302204
100Other types of O-glycan biosynthesis_Homo sapiens_hsa005140.50660605
101Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006300.50310643
102Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005630.50169341
103Pyruvate metabolism_Homo sapiens_hsa006200.50166394
104Bacterial invasion of epithelial cells_Homo sapiens_hsa051000.49165359
105Taste transduction_Homo sapiens_hsa047420.48038368
106Ether lipid metabolism_Homo sapiens_hsa005650.46609871
107MAPK signaling pathway_Homo sapiens_hsa040100.46454298
108Long-term depression_Homo sapiens_hsa047300.44433234
109Huntingtons disease_Homo sapiens_hsa050160.43929502
110Nicotine addiction_Homo sapiens_hsa050330.43507858
111Epstein-Barr virus infection_Homo sapiens_hsa051690.43262914
112Terpenoid backbone biosynthesis_Homo sapiens_hsa009000.42447955
113mTOR signaling pathway_Homo sapiens_hsa041500.41539068
114Serotonergic synapse_Homo sapiens_hsa047260.41502871
115Glycine, serine and threonine metabolism_Homo sapiens_hsa002600.41161652
116Non-small cell lung cancer_Homo sapiens_hsa052230.40302990
117Protein digestion and absorption_Homo sapiens_hsa049740.39885352
118One carbon pool by folate_Homo sapiens_hsa006700.39654615
119Prion diseases_Homo sapiens_hsa050200.39641632
120AMPK signaling pathway_Homo sapiens_hsa041520.38969108
121Vascular smooth muscle contraction_Homo sapiens_hsa042700.38925295
122Viral carcinogenesis_Homo sapiens_hsa052030.38838932
123Synthesis and degradation of ketone bodies_Homo sapiens_hsa000720.38803943
124Morphine addiction_Homo sapiens_hsa050320.35290772
125Linoleic acid metabolism_Homo sapiens_hsa005910.34781961
126N-Glycan biosynthesis_Homo sapiens_hsa005100.33967957
127AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa049330.33575624
128Metabolic pathways_Homo sapiens_hsa011000.31820918
129Cytokine-cytokine receptor interaction_Homo sapiens_hsa040600.31362694
130Thyroid hormone signaling pathway_Homo sapiens_hsa049190.31353971
131Sphingolipid metabolism_Homo sapiens_hsa006000.31323596
132Lysine degradation_Homo sapiens_hsa003100.29826001
133ErbB signaling pathway_Homo sapiens_hsa040120.29332351
134Alcoholism_Homo sapiens_hsa050340.26318027
135Neurotrophin signaling pathway_Homo sapiens_hsa047220.26281401
136Hepatitis B_Homo sapiens_hsa051610.25956473
137Apoptosis_Homo sapiens_hsa042100.24659961
138Cytosolic DNA-sensing pathway_Homo sapiens_hsa046230.24592346
139Vasopressin-regulated water reabsorption_Homo sapiens_hsa049620.24578938
140Renal cell carcinoma_Homo sapiens_hsa052110.22736079
141Ovarian steroidogenesis_Homo sapiens_hsa049130.22167533
142Pancreatic cancer_Homo sapiens_hsa052120.21449829
143cGMP-PKG signaling pathway_Homo sapiens_hsa040220.20759846

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